Pakistan journal of pharmaceutical sciences最新文献_第2页

A study on the synergistic effects of neuromodulation and opioid-sparing analgesics in postherpetic neuralgia. 神经调节和阿片类镇痛药对带状疱疹后神经痛的协同作用研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14481.1

Yu He, Wei He, Jun Li

{"title":"A study on the synergistic effects of neuromodulation and opioid-sparing analgesics in postherpetic neuralgia.","authors":"Yu He, Wei He, Jun Li","doi":"10.36721/PJPS.2025.38.5.REG.14481.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14481.1","url":null,"abstract":"Postherpetic neuralgia (PHN) is a common complication of herpes zoster, which seriously affects patients' quality of life. This study analysed the synergistic effect of neuromodulation and opioid dilution analgesics in the treatment of PHN. 120 patients with PHN from Affiliated Hospital of Southwest Medical University between December 2020 and December 2023 were categorized into PR and PO groups, both groups were treated with pulsed radiofrequency, PO group was added with Oxycodone hydrochloride. VAS scores, inflammatory factor indexes [tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10)], immune indexes [percentage of CD4+ T cells, CD8+ T cells, CD4+ /CD8+] and clinical efficacy were mainly evaluated. Secondary indicators included sleep quality (PSQI) scores, anxiety self-assessment (SAS) scores, disease control time, adverse reactions and recurrence rates. Post-treatment, both groups' indicators were significantly improved. IL-2 and IL-10 levels, CD4+ T cells percentage, CD4+ /CD8+ and clinical efficacy were higher in PO group than PR group. VAS score, TNF-α and IL-1β levels, CD8+ T cells percentage, PSQI score, SAS score, disease control time, adverse reaction and recurrence rate were lower than PR group (P<0.05). The combination treatment efficacy of PHN is remarkable and is worth promoting its use in the clinic.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1675-1684"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observations on the effect of Danshen on gastrointestinal function and nutritional proteins after laparoscopic surgery. 丹参对腹腔镜术后胃肠功能及营养蛋白的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13499.1

Jinli Guo, Jingjing Zheng, Boling Lv, Yaxuan Xu, Yinyin Wang, Jiajing Liu, Jing Xia

{"title":"Observations on the effect of Danshen on gastrointestinal function and nutritional proteins after laparoscopic surgery.","authors":"Jinli Guo, Jingjing Zheng, Boling Lv, Yaxuan Xu, Yinyin Wang, Jiajing Liu, Jing Xia","doi":"10.36721/PJPS.2025.38.5.REG.13499.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13499.1","url":null,"abstract":"Recurrent vomiting and sleep disturbance are typical postoperative complications of laparoscopic surgery, how to improve the postoperative gastrointestinal function of patients undergoing laparoscopic surgery is one of the key links to ensure their recovery. In this study, we looked at the effect of danshen acupressure on the postoperative recovery of patients undergoing laparoscopic surgery. For this purpose, we included 105 study subjects, all patients received information-motivation-behavioral skills (IMB) model-based care, of which 51 patients did not receive danshen treatment and were considered as a control group, another 54 patients were treated with danshen and considered as the research group. Comparison of gastrointestinal function between the two groups and nutritional status, psychological status, etc., we found that the gastrointestinal function of the research group recovered better and gastrin (GAS) and motilin (MTL) were lower than those of the control group (P<0.05). Meanwhile, the psychological status of the research group was also better than that of the control group and the level of nutritional protein was higher than that of the control group (P<0.05). Through the prognostic follow-up, we also found a better prognostic quality of life in the research group.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1714-1721"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergency management of traumatic brain injury patients and adherence to treatment guidelines in tertiary care hospitals of Lahore, Pakistan. 巴基斯坦拉合尔三级医院创伤性脑损伤患者的紧急管理和对治疗指南的遵守。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13650.1

Sairah Hafeez Kamran, Aamir Mushtaq, Memona Khalid, Rabia Ashraf, Sara Masud

{"title":"Emergency management of traumatic brain injury patients and adherence to treatment guidelines in tertiary care hospitals of Lahore, Pakistan.","authors":"Sairah Hafeez Kamran, Aamir Mushtaq, Memona Khalid, Rabia Ashraf, Sara Masud","doi":"10.36721/PJPS.2025.38.5.REG.13650.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13650.1","url":null,"abstract":"The cross-sectional prospective study aimed to study the factors associated with traumatic brain injuries (TBIs) and acute management of patients presenting at emergency departments in two tertiary care hospitals in Lahore, Punjab, Pakistan, as well as compliance with international guidelines. Data was collected from 1,000 patients between February 2nd to August 2nd, 2022. Among TBI patients, 82.1% were male, and most TBIs resulted from road traffic accidents (62.6%). Headaches were experienced by 97.8% of patients, while 72.3% experienced vomiting. The diagnostic procedures included X-rays (98.9%) and CT scans (86.4%). The adherence to trauma guidelines at EDs showed blood pressure monitoring in 100% of patients, oxygen monitoring in 69.4% of patients, hyperosmolar therapy (59.2%) and infection prophylaxis (93.65%). Diagnostic procedures like X-ray (98.9%) lactulose (3.3%), anti-seizure prophylaxis (59.9%), steroid therapy (4%) and anesthetic and sedative administration were not in accordance with international guidelines. Intracranial pressure monitoring facility was not available in EDs. Deep vein thrombosis prophylaxis and nutrition were not provided in EDs. This study revealed that emergency management of TBI patients adhered to most of the international guidelines, with prompt diagnosis and therapeutic care provided in both tertiary care hospitals.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1742-1749"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of a novel chalcone derivative from Arisaema utile a selective MAO-B inhibitor in sodium azide-induced rat model. 叠氮化钠诱导大鼠模型中一种新型叠氮化钠查尔酮衍生物的分离与表征。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14310.1

Muhammad Kamran Khan, Malik Saadullah

{"title":"Isolation and characterization of a novel chalcone derivative from Arisaema utile a selective MAO-B inhibitor in sodium azide-induced rat model.","authors":"Muhammad Kamran Khan, Malik Saadullah","doi":"10.36721/PJPS.2025.38.5.REG.14310.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14310.1","url":null,"abstract":"This study aims to investigate the neuroprotective effects of Utilito, a novel chalcone derivative isolated from Arisaema utile in a sodium azide-induced Alzheimer's disease (AD) rat model. Anti-alzheimer activities were assessed through in silico molecular docking, simulation studies and in vivo studies. Utilito at doses of 100, 200, 300 mg/kg was administered in Wistar rats (n=6/group) for 14 days. Cognitive performance and locomotion were assessed through behavioural tests (Morris water maze, Y-maze, and open field). Biochemical assays measured the levels of oxidative stress biomarker including catalase (CAT) superoxide dismutase (SOD), reduced glutathione (GSH), and malondialdehyde (MDA). Molecular docking studies revealed a strong binding affinity of Utilito with monoamine oxidase (MAO-B), with a docking score of -41.4 kJ/mol. Conventional hydrogen bond interactions were observed between the MAO-B residues LEU171, TYR398, and TYR435 and the phenol ring of Utilito. Utilito also showed 71 ± 0.11% anti-oxidant activity in the DPPH assay. Behavioural tests utilizing animal models demonstrate the cognitive-enhancing effects of Utilito. Biochemical evaluations underscore the antioxidant properties of Utilito, offering valuable insights into their mechanisms of action at the cellular level. Utilito exhibits antioxidant activity and cognitive improvement in a rat AD model, suggesting its promise as a therapeutic candidate for AD.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1913-1931"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of magnesium sulfate and atosiban in fetal neuroprotection during high-risk pregnancies. 硫酸镁与阿托西班对高危妊娠胎儿神经保护作用的比较分析。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14018.1

Lijuan Pan, Ning Zhang

{"title":"Comparative analysis of magnesium sulfate and atosiban in fetal neuroprotection during high-risk pregnancies.","authors":"Lijuan Pan, Ning Zhang","doi":"10.36721/PJPS.2025.38.5.REG.14018.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14018.1","url":null,"abstract":"Preterm births could increase the risk of neonatal conditions like cerebral palsy and neurodevelopmental delays. This trial aimed to evaluate the efficacy of magnesium sulfate and atosiban in providing neuroprotection to preterm infants. A clinical trial was conducted between 2020 and 2024, involving 102 high-risk pregnant women at multiple tertiary clinics in China. We studied the neonatal neurodevelopmental delay at 6 months and 12 months whilst also focusing on factors such as maternal side effects, gestational age, mode of delivery, and Neonatal Intensive Care Unit (NICU) admission rates. Unlike magnesium sulfate, Atosiban could reduce the fetus' breathing problems that can, in turn, lead to baby brain protection. It also has fewer maternal side effects, such as nausea and hypertension (p = 0.03). Magnesium sulfate had comparably higher risks of maternal and fetal complications, 49.02% and 68.63% respectively. This study's results suggest that while atosiban is not a commonly used intervention, it is a promising agent for fetal neuroprotection. It is also observed that considering maternal safety, it has fewer side effects. Future larger population studies should be carried out to corroborate the results for higher efficient and safer intervention for fetal neuroprotection.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1685-1693"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined computational and pharmacological approach reveals Citrullus colocynthis as a natural PCSK9 inhibitor in insulin resistant rats. 计算与药理学相结合的方法揭示了Citrullus colocynthis是胰岛素抵抗大鼠的天然PCSK9抑制剂。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14465.1

Hafiz Abdul Sattar Hashmi, Hafiz Muhammad Asif, Khalil Ahmad, Muhammad Younus, Muhammad Naeem

{"title":"Combined computational and pharmacological approach reveals Citrullus colocynthis as a natural PCSK9 inhibitor in insulin resistant rats.","authors":"Hafiz Abdul Sattar Hashmi, Hafiz Muhammad Asif, Khalil Ahmad, Muhammad Younus, Muhammad Naeem","doi":"10.36721/PJPS.2025.38.5.REG.14465.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14465.1","url":null,"abstract":"This study evaluated the therapeutic effects of Citrullus colocynthis seed extract (CCSE) on PCSK9 expression in a high-fat diet (HFD)-induced insulin resistance (IR) model in Wistar rats. Fifteen phytoconstituents from CCSE were screened for drug-likeness using SwissADME and docked against PCSK9 (PDB ID: 6U26). In vivo, 30 HFD-induced-IR rats were divided into five groups: one control (saline) and four treatment groups received CCSE (100,200,300,400 mg/kg) for 28 days. Hepatic PCSK9 mRNA expression was analyzed by qRT-PCR, with relative fold changes. Data were statistically evaluated by ANOVA. In-silico analysis demonstrated all selected compounds complied with Lipinski's Rule of Five, indicated favorable oral bioavailability. Topological polar surface area (TPSA: 9.23-55.38 Å²) and number of rotatable bonds (NRB >10) further supported their drug-like properties. Strong binding affinities were of compounds Cyclopropane carboxylic acid and 2,4-di-tert-butylphenol (-7.4 and -5.5 kcal/mol) to PCSK9. In-vivo results showed that CCSE significantly downregulated hepatic PCSK9 mRNA expression at a dose of 300mg & 400mg/kg (p < 0.05 vs. control), with the highest reduction (3.2-fold) observed at the 400 mg/kg dose. CCSE significantly downregulated hepatic PCSK9 mRNA expression and confirmed through both in-silico and In-vivo approaches. This suggests its potential as a natural therapeutic agent for managing metabolic disorders.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1784-1792"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simo decoction in patients with early liver dysfunction after liver transplantation. 四磨汤对肝移植术后早期肝功能障碍患者的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14853.1

Weihang Zhong, Haijin Lyu, Yuping Li, Jinfeng Zhuo

{"title":"Simo decoction in patients with early liver dysfunction after liver transplantation.","authors":"Weihang Zhong, Haijin Lyu, Yuping Li, Jinfeng Zhuo","doi":"10.36721/PJPS.2025.38.5.REG.14853.1","DOIUrl":"10.36721/PJPS.2025.38.5.REG.14853.1","url":null,"abstract":"Simo decoction was used to treat patients with early liver dysfunction after liver transplantation (LT). We aimed to evaluate its effects on gastrointestinal and liver function. A total of 138 patients were divided into the control (Ctrl) group (standard care + placebo; n=69) or the experimental (Exp) group (standard care combined with Simo decoction; n=69). From postoperative day 1 to 5 (T1-T5), patients' liver and kidney function, blood glucose, blood ammonia, gastric residual volume, defecation time, enteral nutrition intake, adverse events and the co-administration of Simo decoction with tacrolimus were analyzed. Alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin and indirect bilirubin levels all showed decreasing trends, while creatinine, blood glucose and albumin remained stable. Compared with the Ctrl group, the Exp group demonstrated significantly lower blood ammonia levels during T1-T5, earlier defecation time and higher enteral nutrition intake at T4-T5. Although gastric residual volume was higher in the Exp group at T1, it was lower than the Ctrl group at T3-T5 without reaching statistical significance. Simo decoction demonstrated beneficial effects in improving gastrointestinal function and metabolic parameters following LT, facilitating toxin elimination and promoting gastrointestinal recovery, while showing no adverse effects on hepatic or renal function recovery.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1823-1835"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new clinical paradigm for the interpretation of NSAIDs-induced laboratory abnormalities: Threshold-symptom correlation for diagnostic clarity. 解释非甾体抗炎药引起的实验室异常的一个新的临床范例：诊断清晰度的阈值-症状相关性。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.15240.1

Yanyue Zhang, Limin Wang, Feng Dong

{"title":"A new clinical paradigm for the interpretation of NSAIDs-induced laboratory abnormalities: Threshold-symptom correlation for diagnostic clarity.","authors":"Yanyue Zhang, Limin Wang, Feng Dong","doi":"10.36721/PJPS.2025.38.5.REG.15240.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.15240.1","url":null,"abstract":"Nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Diclofenac are often employed but cause minor laboratory test abnormalities in routine examination tests, such as inflammatory markers and liver-renal function tests. They can generate pseudodisease and lead to unnecessary investigation. The present study presents a novel \"interference threshold-clinical symptom correlation\" model that associates lab abnormality with patient complaints or clinical symptoms after NSAID usage to differentiate drug-induced effect from actual disease in primary care. A mixed retrospective-prospective observational study was conducted in 426 patients from three major primary care centers. Retrospective laboratory data and drug exposure history were determined and clinical symptoms were prospectively monitored after withdrawal of NSAID. Logistic regression and threshold modeling established interference ranges for significant laboratory indices. Model performance was assessed by receiver operating characteristic (ROC) analysis with an area under the curve (AUC) of 0.91 (95% CI: 0.87-0.95). The model reduced unnecessary intervention by 46% in an externally validated cohort. Shortcomings include heterogeneity of NSAID type and dose, no control group and difficulty in standardizing correlation between symptom and threshold. This model, however, provides an efficient, pragmatic tool to improve interpretation of laboratory changes in association with NSAID and it enhances patient safety in primary care.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1952-1960"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of intra-articular hyaluronic acid injection combined with oral nonsteroidal anti-inflammatory drugs in the treatment of knee osteoarthritis. 关节内注射透明质酸联合口服非甾体抗炎药治疗膝关节骨性关节炎的疗效观察。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13889.1

Sijun Ruan, Xiqing Cheng

{"title":"The effectiveness of intra-articular hyaluronic acid injection combined with oral nonsteroidal anti-inflammatory drugs in the treatment of knee osteoarthritis.","authors":"Sijun Ruan, Xiqing Cheng","doi":"10.36721/PJPS.2025.38.5.REG.13889.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13889.1","url":null,"abstract":"Knee osteoarthritis (KOA) is a chronic disease with limited clinical treatment and easy recurrence. This study analyze the effectiveness of intra-articular hyaluronic acid (HA) injection combined with oral nonsteroidal anti-inflammatory drugs (NSAID) in treating KOA, providing scientific basis for improving the therapeutic effect of this disease. 100 KOA patients admitted to our hospital from December 2021 to December 2023 were divided into control group (n=50) and study group (n=50). Both groups were treated with oral NSAID, study group were added with intra-articular HA injections. The pain scores (VAS), knee osteoarthritis indicator score (WOMAC), knee osteoarthritis outcome score (KOOS), Lysholm score, knee joint range of motion, inflammatory indicators, clinical efficacy and adverse reactions were compared among both groups. After treatment, all indicators in both groups remarkably improved (P<0.05). The KOOS score, Lysholm score, knee mobility and clinical efficacy in study group were remarkably higher than control group, and VAS score, WOMAC score and inflammatory factor level were less than control group (P<0.05). No significant discrepancies in the adverse reactions among both groups (P>0.05). The efficacy of the combined treatment is remarkable without increased adverse reactions and deserves to further popularize its use in the clinic.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"2006-2015"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients. Ala-Gln二肽肠外营养对肝移植患者康复及感染的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14167.1

Dong Wang, Shangdong Li

{"title":"Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients.","authors":"Dong Wang, Shangdong Li","doi":"10.36721/PJPS.2025.38.5.REG.14167.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14167.1","url":null,"abstract":"This study aimed to explore the application and effect of alanyl-glutamine (Ala-Gln) dipeptide parenteral nutrition support in liver transplantation patients. A randomized controlled trial was performed, including and analyzing 96 patients who underwent liver transplantation surgery in our hospital from March 2019 to February 2023. These 96 patients were randomly divided into an experimental group and a control group, with 48 cases in each group. The control group was supplied with branched-chain amino acids (BCAAs) as a nitrogen source, and the experimental group was supplied with BCAAs + Ala-Gln. The results indicated that the levels of prealbumin (PA), serum albumin (ALB), and transferrin (TRF) in the experimental group were higher than those in the control group (P<0.05). The duration of care at the intensive care unit (ICU) and hospitalization of the experimental group were shorter than the control group (P<0.05). The incidence of infection events of the experimental group was lower than that in the control group (P<0.05). Collectively, the use of Ala-Gln in parenteral nutrition support for liver transplantation patients can significantly improve the nutritional status of the body, shorten the length of hospitalization time and reduce the incidence of infection.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1627-1631"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0