To observe the effect of acetylcysteine combined with diphylline on pulmonary function and inflammatory response in children with bronchopneumonia.

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Lian Zhang
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引用次数: 0

Abstract

Bronchopneumonia is an extremely common respiratory disease in children, which may cause bronchiectasis, respiratory failure, and other complications. In this study, we observed the effect of acetylcysteine combined with diphylline in the treatment of bronchopneumonia. This includes the session time of the child's cough and wheezing symptoms, lung function, and the inflammatory response before and after treatment. In addition, we also counted the adverse reactions during the treatment of the children. The results of the study showed that children in the research group treated with acetylcysteine combined with diphylline had a shorter time to symptomatic relief compared to the control group using bronchopneumonia (P<0.05). Also, the lung function after treatment was better in the research group than in the control group, and the levels of inflammatory factors were lower in the research group than in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). These results suggest that acetylcysteine combined with diphylline has excellent potential for the treatment of bronchopneumonia.

目的观察乙酰半胱氨酸联合苯酞对支气管肺炎患儿肺功能及炎症反应的影响。
支气管肺炎是一种极为常见的儿童呼吸道疾病,可引起支气管扩张、呼吸衰竭和其他并发症。在本研究中,我们观察了乙酰半胱氨酸联合苯茶碱治疗支气管肺炎的效果。这包括儿童咳嗽和喘息症状的持续时间、肺功能以及治疗前后的炎症反应。此外,我们还统计了患儿在治疗过程中的不良反应。研究结果显示,研究组患儿用乙酰半胱氨酸联合苯茶碱治疗比对照组患儿用支气管肺炎治疗症状缓解时间短(P0.05)。这些结果表明,乙酰半胱氨酸联合苯茶碱治疗支气管肺炎具有良好的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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