氢吗啡酮抑制人工流产中身体运动的ED50：一项剂量发现研究。

IF 0.7 4区医学 Q4 PHARMACOLOGY & PHARMACY

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI:10.36721/PJPS.2025.38.4.REG.13124.1

Lijun Peng, Lingli Liu

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引用次数: 0

摘要

本研究试图探讨氢吗啡酮在人工流产中抑制体运动的中位有效剂量（ED50）。采用上下法将23例女性患者纳入研究。每位患者的氢吗啡酮用量根据流产过程中前侧患者的身体运动是否阳性，呈梯度递减或递增。probit回归分析表明，氢吗啡酮对流产体运动的抑制作用ED50为19.637 μg/kg。该结果可为临床安全、合理使用该药提供参考。

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ED₅₀ of hydromorphone suppressing body movement in artificial abortion: A dose-finding study.

The present study attempted to investigate the median effective dose (ED₅₀) of hydromorphone on suppressing of body movement in artificial abortion. A total of 23 female patients were assigned into the study using the up-and-down method. The usage amount of hydromorphone for each patient was decreased or increased by a gradient, depending on whether the anterior patient's body movement during the abortion procedure is positive or not. By using probit regression analysis, the ED₅₀ of hydromorphone was 19.637 μg/kg for the suppression body movement in abortion. This result may provide a reference for the safety and rational use of the drug in clinic.

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来源期刊

Pakistan journal of pharmaceutical sciences 医学-药学

CiteScore

1.40

自引率

12.50%

发文量

211

审稿时长

4.5 months

期刊介绍： Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.