Improvement of health status of sepsis patients undergoing blood purification therapy by using combination of acetylcysteine and frail management.

Abstract

In this study, the efficacy of Fatigue, Resistance, Ambulation, Illness and Loss of weight (FRAIL) management combined with acetylcysteine (AChE) in blood purification therapy for sepsis (SS) patients was investigated. Seventy-eight SS patients undergoing blood purification were randomized to an observation group (FRAIL + AChE, n=42) or a control group (conventional care, n=36). FRAIL score, APACHE II score, vital signs (heart rate, mean arterial pressure, oxygen saturation), inflammatory factors oxidative stress indexes and nutritional proteins were assessed before and after the intervention in both groups. The results of the study showed that after the intervention, the FRAIL score and APACHE II score were reduced more significantly in the observation group (P<0.05). In addition, vital signs improved more significantly in the observation group. After the intervention, all inflammatory factors in the observation group were lower than those in the control group, while nutritional proteins were higher than those in the control group (P<0.05). In addition, oxidative stress injury was also more favorable in the observation group than in the control group after the intervention. These results suggest that FRAIL management combined with AChE may play a significant role in SS treatment.