{"title":"基于膈肌功能参数评价胸椎旁神经阻滞联合异丙酚麻醉及吸入联合麻醉根治性治疗老年肺癌的风险-收益","authors":"Feng Han, Xin-Xin Tian","doi":"10.36721/PJPS.2025.38.4.REG.13370.1","DOIUrl":null,"url":null,"abstract":"<p><p>To evaluate the benefit-risk of thoracic complex propofol anesthesia for elderly lung cancer based on diaphragm function parameters. 137 elderly patients with lung cancer undergoing radical resection of thoracic surgery at Hangzhou First People's Hospital were selected. The patients were divided into: paravertebral complex propofol anesthesia (PPA, N = 68) group and static aspiration compound anesthesia (SGA, N. = 69) group. In the PPA group, the amount of remifentanil, postoperative sufentanl, 24h, anesthesia onset time, eye opening time, directional force recovery time, instruction time, IL-10, 6h, 12h, 48 h VAS score, active cough at 6h, 12h, 24 h, postoperative respiratory depression, upper airway obstruction, pulmonary complications were significantly lower than the SGA group (P <0.05), The diaphragm function parameters DTF, DD and diaphragm contraction velocity were significantly higher than those in the SGA group (P> 0.05); The benefit values of the PPA and SGA groups were 83, 47, Risk values were 17, respectively, 39, Benefit-total risk of 55, 36. The benefit-risk value was highest in PPA group. PPA anesthesia can not only effectively improve the effect of radical resection of elderly lung cancer on diaphragm function, but also has the characteristics of high anesthesia quality and few adverse reactions.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1498-1508"},"PeriodicalIF":0.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the risk-benefit of thoracic paravertebral nerve block combined with propofol anesthesia and inhalation combined anesthesia for radical treatment in elderly lung cancer based on diaphragm functional parameters.\",\"authors\":\"Feng Han, Xin-Xin Tian\",\"doi\":\"10.36721/PJPS.2025.38.4.REG.13370.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To evaluate the benefit-risk of thoracic complex propofol anesthesia for elderly lung cancer based on diaphragm function parameters. 137 elderly patients with lung cancer undergoing radical resection of thoracic surgery at Hangzhou First People's Hospital were selected. The patients were divided into: paravertebral complex propofol anesthesia (PPA, N = 68) group and static aspiration compound anesthesia (SGA, N. = 69) group. In the PPA group, the amount of remifentanil, postoperative sufentanl, 24h, anesthesia onset time, eye opening time, directional force recovery time, instruction time, IL-10, 6h, 12h, 48 h VAS score, active cough at 6h, 12h, 24 h, postoperative respiratory depression, upper airway obstruction, pulmonary complications were significantly lower than the SGA group (P <0.05), The diaphragm function parameters DTF, DD and diaphragm contraction velocity were significantly higher than those in the SGA group (P> 0.05); The benefit values of the PPA and SGA groups were 83, 47, Risk values were 17, respectively, 39, Benefit-total risk of 55, 36. The benefit-risk value was highest in PPA group. PPA anesthesia can not only effectively improve the effect of radical resection of elderly lung cancer on diaphragm function, but also has the characteristics of high anesthesia quality and few adverse reactions.</p>\",\"PeriodicalId\":19971,\"journal\":{\"name\":\"Pakistan journal of pharmaceutical sciences\",\"volume\":\"38 4\",\"pages\":\"1498-1508\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan journal of pharmaceutical sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.36721/PJPS.2025.38.4.REG.13370.1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan journal of pharmaceutical sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36721/PJPS.2025.38.4.REG.13370.1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
基于膈肌功能参数评价胸腔复合异丙酚麻醉治疗老年肺癌的获益与风险。选取杭州市第一人民医院行胸外科根治性切除的老年肺癌患者137例。将患者分为:椎旁复合异丙酚麻醉(PPA, N = 68)组和静吸复合麻醉(SGA, N = 69)组。PPA组患者瑞芬太尼用量、术后舒芬太尼24h用量、麻醉起效时间、睁开眼时间、方向力恢复时间、指导时间、IL-10、6h、12h、48h VAS评分、6h、12h、24h活动性咳嗽、术后呼吸抑制、上气道阻塞、肺部并发症均显著低于SGA组(P < 0.05);PPA组和SGA组的获益值分别为83、47,风险值分别为17、39,获益-总风险分别为55、36。PPA组的获益风险值最高。PPA麻醉不仅能有效提高老年肺癌根治术对膈肌功能的影响,而且具有麻醉质量高、不良反应少的特点。
Evaluation of the risk-benefit of thoracic paravertebral nerve block combined with propofol anesthesia and inhalation combined anesthesia for radical treatment in elderly lung cancer based on diaphragm functional parameters.
To evaluate the benefit-risk of thoracic complex propofol anesthesia for elderly lung cancer based on diaphragm function parameters. 137 elderly patients with lung cancer undergoing radical resection of thoracic surgery at Hangzhou First People's Hospital were selected. The patients were divided into: paravertebral complex propofol anesthesia (PPA, N = 68) group and static aspiration compound anesthesia (SGA, N. = 69) group. In the PPA group, the amount of remifentanil, postoperative sufentanl, 24h, anesthesia onset time, eye opening time, directional force recovery time, instruction time, IL-10, 6h, 12h, 48 h VAS score, active cough at 6h, 12h, 24 h, postoperative respiratory depression, upper airway obstruction, pulmonary complications were significantly lower than the SGA group (P <0.05), The diaphragm function parameters DTF, DD and diaphragm contraction velocity were significantly higher than those in the SGA group (P> 0.05); The benefit values of the PPA and SGA groups were 83, 47, Risk values were 17, respectively, 39, Benefit-total risk of 55, 36. The benefit-risk value was highest in PPA group. PPA anesthesia can not only effectively improve the effect of radical resection of elderly lung cancer on diaphragm function, but also has the characteristics of high anesthesia quality and few adverse reactions.
期刊介绍:
Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013.
PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.