Pakistan journal of pharmaceutical sciences最新文献

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Multimodal MR functional imaging for pathological grading and monitoring trastuzumab response in HER2-positive breast cancer. 多模态磁共振功能成像用于her2阳性乳腺癌的病理分级和监测曲妥珠单抗反应。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.15088.1
Luo Songjiang, Liu Feng, Wang Wei, Li Siyu, Wu Xiaoqing, Luo Tenglong
{"title":"Multimodal MR functional imaging for pathological grading and monitoring trastuzumab response in HER2-positive breast cancer.","authors":"Luo Songjiang, Liu Feng, Wang Wei, Li Siyu, Wu Xiaoqing, Luo Tenglong","doi":"10.36721/PJPS.2025.38.5.REG.15088.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.15088.1","url":null,"abstract":"<p><p>Accurate noninvasive assessment of tumor grade and therapeutic response in HER2-positive breast cancer remains challenging. This prospective, single-center study aimed to evaluate the diagnostic value of multimodal MR functional imaging in grading malignant breast tumors and monitoring trastuzumab response. Eighty HER2-positive patients confirmed by IHC/FISH were enrolled, including 41 low-grade and 39 high-grade tumors (Nottingham grading system). Patients underwent comprehensive MR imaging, including diffusion tensor imaging, MR spectroscopy and perfusion imaging at baseline and during therapy. Tumor morphological features (size, necrosis, hemorrhage, edema, boundary clarity) and functional MR parameters (FA, tCho, MTT, TTP) were analyzed for correlation with pathological grade and treatment response. High-grade tumors showed larger size, more necrosis, hemorrhage and edema (P<0.05). Functional MR parameters, particularly tCho, MTT and TTP, correlated positively with tumor grade (P<0.05). ROC analysis demonstrated high diagnostic accuracy (sensitivity 89.2%, specificity 79.5%, AUC=0.887). Typical MR imaging patterns also reflected trastuzumab responsiveness, indicating potential for noninvasive monitoring of therapy. Multimodal MR functional imaging thus provides a sensitive and specific tool for tumor grading and evaluation of targeted therapeutic response.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1898-1905"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using network pharmacology and molecular docking to investigate the mechanism of action of the active components of agarwood moxibustion therapy for the treatment of chronic atrophic gastritis. 采用网络药理学和分子对接的方法,探讨沉香灸疗法有效成分治疗慢性萎缩性胃炎的作用机制。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14241.1
Weiyan Wu, Siyu Chen, Yucheng Xia, Zixiao Jiang, Tiandong Lin, Mingming Zhao, Yangyang Liu
{"title":"Using network pharmacology and molecular docking to investigate the mechanism of action of the active components of agarwood moxibustion therapy for the treatment of chronic atrophic gastritis.","authors":"Weiyan Wu, Siyu Chen, Yucheng Xia, Zixiao Jiang, Tiandong Lin, Mingming Zhao, Yangyang Liu","doi":"10.36721/PJPS.2025.38.5.REG.14241.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14241.1","url":null,"abstract":"<p><p>Chronic atrophic gastritis (CAG) is a long-term inflammatory condition of the gastric mucosa characterized by glandular atrophy, intestinal metaplasia and reduced acid secretion, often considered a precancerous lesion of the stomach. This study utilized a combined network pharmacology and molecular docking approach to elucidate the mechanisms of moxibustion therapy against CAG. Disease-related targets were retrieved from GeneCards, OMIM, PharmaGkb, TTD and DrugBank, while moxibustion's active components and their targets were sourced from TCMSP database. Overlapping targets between the drug and disease were identified, representing potential therapeutic targets. Cytoscape was employed to construct component-target networks and R was used for GO and KEGG enrichment analyses. STRING database facilitated protein-protein interaction network construction and identification of key targets. Molecular docking, via AutoDock, validated component-target interactions. Eighteen common targets were identified from 379 drug targets and 361 disease targets, linked to 18 active components. Topological analysis pinpointed TP53, IL-1β, PTGS2, CXCL8, CASP8 and STAT1 as crucial targets. KEGG enrichment revealed involvement of TNF-κB, p53, IL-17 and Toll-like receptor signaling pathways. Molecular docking confirmed stable binding between key components and targets. These findings suggest that moxibustion's therapeutic effects on CAG are mediated through modulation of immune, inflammatory and tumor-related pathways.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1846-1858"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of functionalized benzofuran esters through Suzuki-Miyaura cross-coupling reactions, their DFT and pharmacological studies. Suzuki-Miyaura交叉偶联反应合成功能化苯并呋喃酯及其DFT和药理学研究。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13765.1
Lal Khan, Muhammad Zubair
{"title":"Synthesis of functionalized benzofuran esters through Suzuki-Miyaura cross-coupling reactions, their DFT and pharmacological studies.","authors":"Lal Khan, Muhammad Zubair","doi":"10.36721/PJPS.2025.38.5.REG.13765.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13765.1","url":null,"abstract":"<p><p>The Suzuki-Miyaura cross-coupling reaction was used to synthesize phenylbenzofuran-2-carboxylate derivatives (4a- 4f). The structural features of the target molecules were analyzed using two computational tools, e.g., molecular docking and DFT studies. Based on computational studies, target molecules were further screened for hemolytic and enzyme inhibitory activity, e.g., anti-urease and α-glucosidase, investigated to evaluate their biological potential. Hemolytic assay findings indicate that synthesized molecules 4a-4f are non-toxic to RBCs, while Compound (4d) and (4a) showed excellent anti-urease and α-glucosidase inhibitory activity (IC<sub>50</sub> =13.38 ±1.75µM and (IC<sub>50</sub> = 60.5 ±1.53 µM). comparable to standard drugs. DFT and molecular docking predictions of structural features supported the experimental results. Most and least reactive molecules in this series (4a-4f) are identified by comparing energies (ΔE). 4f exhibits the lowest ∆E of 3.20 eV, indicating its least stability in the synthesized series (4a-4f). In contrast, 4b displays the highest ∆E gap of 6.42 eV, suggesting its highest stability and least reactivity. In this work, computational and in vitro methodologies provided complimentary insights for effective molecular screening of drug candidates, specifically in terms of binding affinity and toxicity profiles.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1516-1527"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel cabozantinib-sulfasalazine combination targeting ferroptosis to overcome resistant immunotherapy in advanced hepatocellular carcinoma. 一种新的卡博替尼-磺胺嘧啶联合靶向铁下垂以克服晚期肝细胞癌的耐药免疫治疗。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.15087.1
Bei Wang, Gangcheng Kong, Chaoyang Meng, Chunhui Nie, Dalong Wan
{"title":"A novel cabozantinib-sulfasalazine combination targeting ferroptosis to overcome resistant immunotherapy in advanced hepatocellular carcinoma.","authors":"Bei Wang, Gangcheng Kong, Chaoyang Meng, Chunhui Nie, Dalong Wan","doi":"10.36721/PJPS.2025.38.5.REG.15087.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.15087.1","url":null,"abstract":"<p><p>Advanced hepatocellular carcinoma (HCC) frequently develops resistance to immunotherapy, resulting in limited treatment options and poor prognosis. Ferroptosis, an iron-dependent regulated form of cell death, may help overcome drug resistance, and cabozantinib has shown clinical efficacy in advanced HCC. In this single-arm retrospective study at the First Affiliated Hospital, Zhejiang University School of Medicine, 60 patients with immunotherapy-refractory HCC received cabozantinib combined with sulfasalazine (1,500 mg/day in three divided oral doses) between August 2021 and August 2024. Tumor response was assessed using RECIST v1.1, while progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier methods and exploratory Cox regression. The combination achieved an objective response rate of 40% (95% CI: 28-53%) and a disease control rate of 70% (95% CI: 58-81%), with median PFS of 8.5 months (95% CI: 6.9-10.1) and median OS of 15.3 months (95% CI: 12.9-17.7). Adverse events were mostly grade 1-2 and manageable, consistent with cabozantinib's known safety profile. These findings suggest encouraging antitumor activity, tolerability, and a potential synergistic effect, though the retrospective single-center design may introduce bias. Prospective randomized studies are warranted to confirm these results and further explore this combination's potential in overcoming immunotherapy resistance.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1906-1912"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of traditional Chinese medicine transdermal therapy in preventing lower limb deep vein thrombosis in chronic glomerulonephritis and uremic patients. 中药透皮疗法预防慢性肾小球肾炎、尿毒症患者下肢深静脉血栓形成的疗效观察。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14686.1
Wei Yong
{"title":"Effectiveness of traditional Chinese medicine transdermal therapy in preventing lower limb deep vein thrombosis in chronic glomerulonephritis and uremic patients.","authors":"Wei Yong","doi":"10.36721/PJPS.2025.38.5.REG.14686.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14686.1","url":null,"abstract":"<p><p>The aim of this study was to assess the impact of traditional Chinese medicine-based transdermal treatment for the prevention of deep vein thrombosis of the lower limbs in patients with chronic glomerulonephritis and uremia. 100 patients hospitalized from January 2022 to July 2024 were randomly divided into a control group (n=50), which was given routine treatment and a study group (n=50), which was given TCM transdermal treatment in addition to herbal formulations at certain acupoints. The treatment was conducted for a period of one month. Clinical endpoints evaluated were the occurrence of deep venous thrombosis (DVT), lower limb pain, Homans sign, femoral triangle tenderness, limb circumference, femoral venous blood flow and coagulation function in terms of prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count (PLT), fibrinogen (FIB) and D-dimer (D-D). The study group presented with significantly lower incidence of DVT, improved venous blood flow and reduced limb swelling and pain compared to the control group (P<0.05). PT and APTT were significantly longer and PLT, FIB and D-D levels were decreased (P<0.05). No severe adverse events were observed and treatment compliance was improved in the study group. These findings suggest that TCM-guided transdermal therapy is a safe and effective adjunctive method for reducing DVT risk in CGN uremia patients.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1859-1866"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the safety of 1% voriconazole ear drops for the treatment of tympanic membrane perforation-associated suppurative otomycosis. 1%伏立康唑滴耳液治疗鼓膜穿孔相关性化脓性耳真菌病的安全性评价。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14677.1
Mao Jin, Yuan Zhao, Zhanwei Dong, Yuejiao Zhang, Lei Zhang, Xinxin Yang, Rui Du, Shoude Zhang
{"title":"Evaluation of the safety of 1% voriconazole ear drops for the treatment of tympanic membrane perforation-associated suppurative otomycosis.","authors":"Mao Jin, Yuan Zhao, Zhanwei Dong, Yuejiao Zhang, Lei Zhang, Xinxin Yang, Rui Du, Shoude Zhang","doi":"10.36721/PJPS.2025.38.5.REG.14677.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14677.1","url":null,"abstract":"<p><p>Otomycosis is a common otolaryngologic condition commonly complicated by tympanic membrane perforation (TMP). Although topical voriconazole has been found effective in TMP-free otomycosis, data on its safety in TMP-associated otomycosis are limited. This study was conducted to determine the safety profile of 1% ear drops of voriconazole in a rabbit model of TMP-associated suppurative otomycosis due to a clinical isolate of Aspergillus terreus. The local preparation was applied three times daily for seven consecutive days. Therapeutic efficacy was assessed by otoendoscopy, while safety was established by brainstem auditory evoked potential (BAEP) assessment and scanning electron microscopy (SEM) of cochlear hair cells. Serum levels of voriconazole were also quantified to assess systemic absorption. No difference was noted in pre- and post-treatment auditory thresholds (27 ± 6.75 dB vs. 27 ± 4.83 dB, P > 0.99). SEM examination demonstrated no damage to cochlear hair cells, and serum voriconazole concentrations remained undetectable after application. The results conclude that 1% voriconazole ear drops are safe for the treatment of TMP-associated suppurative otomycosis in this animal model. Limitations are that only one species of fungi and a preparation made at home were utilized, and further studies with other pathogens and commercial preparations are needed.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1775-1783"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application value of dexmedetomidine and midazolam combined with ultrasound-guided brachial plexus block anesthesia in patients with humeral fractures. 右美托咪定、咪达唑仑联合超声引导下臂丛阻滞麻醉在肱骨骨折中的应用价值。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14098.1
Dongjing Huo, CaiZhi Zhang, Lijie Li, Rong Zeng
{"title":"Application value of dexmedetomidine and midazolam combined with ultrasound-guided brachial plexus block anesthesia in patients with humeral fractures.","authors":"Dongjing Huo, CaiZhi Zhang, Lijie Li, Rong Zeng","doi":"10.36721/PJPS.2025.38.5.REG.14098.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14098.1","url":null,"abstract":"<p><p>This study aims to compare the efficacy and safety of dexmedetomidine and midazolam in patients undergoing humeral fracture surgery. Patients who underwent humeral fracture surgery in our hospital from July 2015 to December 2023 were retrospectively selected. Among the ultrasound-guided brachial plexus nerve block anesthesia protocol, 71 cases used midazolam and were included in Group A, 83 cases used dexmedetomidine and were included in Group B. The fluctuations of heart rate and mean arterial pressure in Group B were smaller than those in Group A. The onset time of sensory and motor block in Group B was shorter than that, while the maintenance time of sensory and motor block was longer. The sedative effect was higher (0.5 hours) after the start of the operation and at the end of the operation in Group B. The pain degree of Group B at 2, 8 and 12 hours after the operation was lower. The cognitive functions in Group B were higher at 30 minutes and 24 hours after the operation. There was no significant difference in the incidence of adverse reactions between the two groups. Dexmedetomidine can be given priority as an anesthetic drug for humeral fracture surgery.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1804-1812"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical effectiveness of polyvinyl alcohol in post-cataract dry eye and their effects on ccl1, IL-13 and IL-10 tear levels. 聚乙烯醇治疗白内障后干眼的临床疗效及对ccl1、IL-13、IL-10泪液水平的影响
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14676.1
Yubo Wu, Yanjie Hao
{"title":"Clinical effectiveness of polyvinyl alcohol in post-cataract dry eye and their effects on ccl1, IL-13 and IL-10 tear levels.","authors":"Yubo Wu, Yanjie Hao","doi":"10.36721/PJPS.2025.38.5.REG.14676.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14676.1","url":null,"abstract":"<p><p>This research evaluated the clinical effectiveness of PVA eye drops in the treatment of post-cataract dry eye and their effects on tear levels of CCL1, IL-13 and IL-10. From January 2021 to January 2023, 100 patients with post-cataract dry eye were randomly assigned into control (conventional treatment) and study groups (conventional + PVA), 50 in each group. Outcome measures included symptom relief, stability of the tear film, Ocular Surface Disease Index (OSDI), cytokine levels (CCL1, IL-13, IL-10) and safety. The study group had a higher effective rate (96.0%) than controls (88.0%, P<0.05). Both groups had lower CCL1 and IL-13 and higher IL-10 after treatment, with greater responses in the PVA group (P<0.05). Tear breakup time, Schirmer's test, fluorescein staining and OSDI were similarly improved more in the PVA group. No side effects, such as burning, foreign body sensation, or congestion, were noted. These results confirm the application of PVA eye drops as tolerable and efficacious therapy for post-cataract surgery dry eye by improving tear film stability and modulating inflammatory cytokines.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1883-1888"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of pharmacist-driven QT interval prolongation in cardiac patients: Application of Framingham's heart rate corrected QT interval formula and the Tisdale risk score. 评估药理学驱动的心脏病患者QT间期延长:Framingham心率校正QT间期公式和Tisdale风险评分的应用
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14426.1
Ahmad Ullah Humza, Sadia Ghousia Baig, Zafar Iqbal, Gul Sama, Imran Ahmed, Amna Hamza
{"title":"Assessment of pharmacist-driven QT interval prolongation in cardiac patients: Application of Framingham's heart rate corrected QT interval formula and the Tisdale risk score.","authors":"Ahmad Ullah Humza, Sadia Ghousia Baig, Zafar Iqbal, Gul Sama, Imran Ahmed, Amna Hamza","doi":"10.36721/PJPS.2025.38.5.REG.14426.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14426.1","url":null,"abstract":"<p><p>QTc interval prolongation is a clinical concern in critically ill cardiac patients. Pharmacist-driven approaches that utilize accurate QTc interval measurements and risk stratification tools are essential for identifying high-risk patients and preventing arrhythmic events. This study evaluates the application of Framingham's heart rate corrected QT interval (QTc) formula and the Tisdale risk score for identifying QTc interval prolongation. This prospective observational study was conducted at the National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan. A total of 485 patients were analyzed. Of 485 patients, 71 (14.6%) exhibited QTc interval prolongation. Among them, 6 (1.2%) exhibited severe QTc interval prolongation, with values >500 ms. The Tisdale risk score classified 67.6% of the patients as high-risk before the intervention, and reduced to 36.6% post-intervention. Older patients (≥60 years) were significantly more likely to exhibit QTc interval prolongation, particularly in the >500 ms. Risk factors for QTc interval prolongation included female sex, hypokalemia, and the use of multiple QTc interval prolonging medications. This study underscores the importance of combining Framingham's formula and the Tisdale risk score, with pharmacist involvement, to accurately assess QTc interval prolongation and optimize patient management, enhancing safety and reducing arrhythmic risk in critically ill cardiac patients.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1539-1546"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To assess the Ginkgo biloba extracts and vestibular rehabilitation training for improving prognosis in vestibular neuritis. 探讨银杏叶提取物和前庭康复训练对改善前庭神经炎预后的作用。
IF 0.7 4区 医学
Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13599.1
Qinglin Wang, Yamin Liu, Xiangdong Guo
{"title":"To assess the Ginkgo biloba extracts and vestibular rehabilitation training for improving prognosis in vestibular neuritis.","authors":"Qinglin Wang, Yamin Liu, Xiangdong Guo","doi":"10.36721/PJPS.2025.38.5.REG.13599.1","DOIUrl":"10.36721/PJPS.2025.38.5.REG.13599.1","url":null,"abstract":"<p><p>The purpose of this research was to assess the impact of supplemental Ginkgo biloba extracts when administered in conjunction with vestibular rehabilitation training (VRT) to enhance patient outcomes in patients with vestibular neuritis (VN). A randomized controlled trial was conducted with 80 participants divided into two groups: Group A (Ginkgo biloba extracts+ VRT) and Group B (VRT only). It was established in the study that the integration of Ginkgo biloba extracts with VRT gave improved results, shorter treatment period, higher postural stability, and better quality of life than the group that received only VRT. Neuroprotective, anti-inflammatory and vasodilatory effects of Ginkgo biloba extracts were instrumental in helping compensate for the vestibular damage and therefore aid in recovery. This study has indicated that supplementing with Ginkgo biloba extracts alongside VRT is a better treatment approach when treating patients with 'persistent' VN.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1664-1674"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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