Pakistan journal of pharmaceutical sciences最新文献_第4页

Changes in liver function, fluctuations in blood glucose, insulin secretion and gender differences in patients with hyperthyroidism after treatment with propranolol hydrochloride tablets coalition with methimazole tablets. 盐酸普萘洛尔片联合甲巯咪唑片治疗甲亢患者肝功能、血糖波动、胰岛素分泌的变化及性别差异。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-09-01

Jianying Hu, Jiajia Dong, Weihong Huang, Yongxin Lin, Jianming Hong, Mingyong Cai

{"title":"Changes in liver function, fluctuations in blood glucose, insulin secretion and gender differences in patients with hyperthyroidism after treatment with propranolol hydrochloride tablets coalition with methimazole tablets.","authors":"Jianying Hu, Jiajia Dong, Weihong Huang, Yongxin Lin, Jianming Hong, Mingyong Cai","doi":"","DOIUrl":"","url":null,"abstract":"To investigate liver function changes, blood glucose fluctuation, insulin secretion and gender differences in hyperthyroidism patients before and after propranolol with methimazole. Clinical data 110 hyperthyroidism patients admitted to Zhangzhou Affiliated Hospital of Fujian Medical University from February 2023 to February 2024 were retrospectively analyzed. They were categorized into the methimazole group (methimazole, n = 55) and the coalition medication group (Methimazole with propranolol, n = 55). The therapeutic effects of both groups were observed. Pre- and post-treatment liver function dynamic blood glucose parameters and insulin secretion characteristics were analyzed between the two groups. Gender differences prior to treatment were also examined. Overall efficacy was significantly higher in the oalition group (96.35%) than in the methimazole group (83.64%) (P<0.05); Post-treatment, the TBiL, AST, ALT, FT3, FT4, FBG, P1BG, HOMA-IR, HOMA-β, postprandial blood glucose peak value, LAGE, MAGE, MODD and SDBG levels in the coalition group were lower compared to the methimazole group, while TSH was higher (P<0.05). Female patients exhibited significantly lower LAGE, MAGE, MODD and SDBG levels compared to the male group (P<0.05). The combination of methimazole and propranolol enhances thyroid and liver functions for hyperthyroid patients while improving insulin resistance along with reducing postprandial blood glucose variability.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active mechanism of "Zishen Huayu Fang" in treating intrauterine adhesions based on network pharmacology and macromolecular docking. 基于网络药理学和大分子对接的 "紫参化瘀方 "治疗宫腔粘连的活性机理研究

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-09-01

Lei Tian, Yueying Huang, Zhongju Chen

{"title":"Active mechanism of \"Zishen Huayu Fang\" in treating intrauterine adhesions based on network pharmacology and macromolecular docking.","authors":"Lei Tian, Yueying Huang, Zhongju Chen","doi":"","DOIUrl":"","url":null,"abstract":"The study is investigating the mechanism of therapeutics of \"Zishen Huayu Fang\" in the adhesions of intrauterine. Pharmacology systems have been employed as active ingredients of 131 compounds like Luteolin, Quercetin and Kaempferol in this research study in a combination of other compounds to prove the efficacy of the Zishen Huayu Fang in the treatment of adhesions inside the uterus. The study aims to understand how the ingredients in \"Zishen Huayu Fang\" interact with the body, particularly how they can assist in the prevention, mitigation and elimination of adhesions inside the uterus. KEGG and GO databases and tools are used to analyze gene functions and interactions in the proposed research study. The signaling pathways such as PI3K-Akt, AGE-RAGE, HIF-1, TNF, are involved in the study to understand the critical aspects of cellular function, such as inflammation, metabolism and cell survival. This study is examining how the formula affects these crucial pathways, which could be linked to its therapeutic effects on uterine adhesions. The study suggests that \"Zishen Huayu Fang\" influences the expression of key targets, particularly STAT3, MAPK1, AKT1, HSP90AA1 and JUN, through active ingredients, providing a foundation for further investigation into its therapeutic efficacy in intrauterine adhesions.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the cytotoxic and antioxidant activities Buxus wallichiana Baill leaf extract against U 87 glioblastoma. 评估 Buxus wallichiana Baill 叶提取物对 U 87 胶质母细胞瘤的细胞毒性和抗氧化活性。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Sabiha Gul, Humera Khatoon, Aisha Aziz, Sumbul Zehra, Syeda Abiha Rizvi, Zabab Khan

{"title":"Evaluation of the cytotoxic and antioxidant activities Buxus wallichiana Baill leaf extract against U 87 glioblastoma.","authors":"Sabiha Gul, Humera Khatoon, Aisha Aziz, Sumbul Zehra, Syeda Abiha Rizvi, Zabab Khan","doi":"","DOIUrl":"","url":null,"abstract":"The scientific community has been drawn towards natural plant resources due to the rising success rates. This work aimed to explore the phytochemical, antioxidant and anti-cancer properties of an ethanolic extract derived from the leaves of Buxus wallichiana Baill. which is utilized in traditional medicine in the treatment of various disease such as respiratory disorders, GI disorders and inflammation. Chemical composition of the ethanolic extract of BW leaves was evaluated by using Gas chromatography-mass spectrometry and phytochemical analysis. Moreover, anti-oxidant and anticancer activity was carried out through 2,2-diphenyl-1-picryl hydrazyl scavenging activity method and 3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay against human glioblastoma cell line. ANOVA test was used to analyze the results followed by Bonferoni's post hoc. Results were significant at P <0.05 and demonstrated that, blocking the production of free radicals also caused tumor cell proliferation on the U 87 MG. Thus, the results show the same pattern of toxicity as indicated by the American National Cancer Institute. The minimum dose for cytotoxic activity of the crude extract was less than 30μg/mL. BW leave extract is considered to have promising anticancer potential as well as antioxidant due to the presence of potent compounds and could become a source of treatment with minimum side effects.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and α-glucosidace inhibitory activities of the Andrographis paniculata Nees. ultrasonic leaf extract. 穿心莲超声叶提取物的抗氧化和α-葡萄糖苷酶抑制活性。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Andita Utami, Candra Irawan, Maman Sukiman, - Ismail, Imalia Dwi Putri, Andrean Nur Pratama, Wira Aditia Septian

{"title":"Antioxidant and α-glucosidace inhibitory activities of the Andrographis paniculata Nees. ultrasonic leaf extract.","authors":"Andita Utami, Candra Irawan, Maman Sukiman, - Ismail, Imalia Dwi Putri, Andrean Nur Pratama, Wira Aditia Septian","doi":"","DOIUrl":"","url":null,"abstract":"Different natural products derived from plants have long been utilized as traditional herbal remedies to treat a variety of ailments and these substances have inspired the design, discovery and development of new pharmaceuticals. Andrographis paniculata is an annual plant that is frequently grown for therapeutic purposes in Southeast Asian countries. The A. paniculata Nees is an Indonesian natural plant that is thought to have antioxidant, anti-diabetic, anti-inflammatory and anti-hyperlipidemic properties. In this study, ultrasonic-assisted extraction (UAE) was used to optimize extraction conditions by varying time and amplitude. Furthermore, the UAE extract was evaluated for antioxidant activity utilizing 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), iron reducing antioxidant power (FRAP), and copper ion reducing antioxidant capacity (CUPRAC), as well as its anti-diabetic potential via α-glucosidase inhibition. Based on antioxidant activity with an IC50 value of 73.71 ±0.28, extract B (extraction time 35 minutes and amplitude 65%) was considered to have optimum conditions for extraction. In addition, it was found that extract A. paniculata (extraction time 30 minutes and amplitude 60%) showed the most active inhibitory activity against α-glucosidase, with an IC50 value of 0.87 ±0.003. The A. paniculata ethanolic leaf extract exhibits antioxidant and anti-diabetic properties.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute toxicity and antidiabetic effect of the ethyl acetate fraction of Commelina diffusa Burm.f. on the high-fat diet and streptozotocin-induced type 2 diabetic mice. 白花蛇舌草乙酸乙酯馏分对高脂饮食和链脲佐菌素诱导的 2 型糖尿病小鼠的急性毒性和抗糖尿病作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Xuan Tung Nguyen, Duc Loi Vu, Thi Van Anh Nguyen, Thi Minh Thu Nguyen, Hong Duong Le

{"title":"Acute toxicity and antidiabetic effect of the ethyl acetate fraction of Commelina diffusa Burm.f. on the high-fat diet and streptozotocin-induced type 2 diabetic mice.","authors":"Xuan Tung Nguyen, Duc Loi Vu, Thi Van Anh Nguyen, Thi Minh Thu Nguyen, Hong Duong Le","doi":"","DOIUrl":"","url":null,"abstract":"Pharmacological studies proved that Commelina diffusa Burm.f. performs various biological activities. Nevertheless, the scientific evidence supporting the hypoglycemic activities of this medicinal plant is insufficient. Thus, this study aims to assess the acute toxicity and the antidiabetic activity of the ethyl acetate fraction of Commelina diffusa (CD.EAF) in type 2 diabetic mice model induced by a high-fat diet and streptozotocin injection. The oral acute toxicity assessment was conducted following Lorke's method. The in vivo study was conducted by feeding Swiss male mice with a high-fat diet for 8 weeks and giving them a single intraperitoneal injection of streptozotocin at 100mg/kg. When the experimental mice model was successfully induced, the CD.EAF at 100mg/kg/day and 300mg/kg/day doses were orally administered to animals for 14 days. After the treatment period, the repeated daily administration of the CD.EAF at both tested doses exposed significant antihyperglycemic activities in comparison with the untreated diabetic group (p<0.05). However, it did not affect the serum lipid levels of mice. Besides, there were significant ameliorations in the histopathological images of the liver and pancreas in mice treated with the CD.EAF. Our findings suggested that the CD.EAF might be a potential agent for drug development to prevent and treat type 2 diabetes.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of ilaprazole combined with somatostatin on severe acute pancreatitis and the effects on oxidative stress and inflammatory response. 伊拉唑联合索马他汀对重症急性胰腺炎的临床疗效及其对氧化应激和炎症反应的影响

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Hao Zhang, Guanghui Zhang, Fengming Xiang, Fen Yang

{"title":"Clinical efficacy of ilaprazole combined with somatostatin on severe acute pancreatitis and the effects on oxidative stress and inflammatory response.","authors":"Hao Zhang, Guanghui Zhang, Fengming Xiang, Fen Yang","doi":"","DOIUrl":"","url":null,"abstract":"This study investigates the clinical efficacy of ilaprazole combined with somatostatin on severe acute pancreatitis (SAP) and the effects on oxidative stress and inflammatory response. Seventy SAP patients were randomized to the control and observation groups, which received the somatostatin treatment and ilaprazole combined with somatostatin treatment for seven days, respectively. Results found that, the time of abdominal pain relief, time of serum amylase recovery, time of urinary amylase recovery and time of defecation recovery in the observation group were shorter than those in the control group (P<0.05). After the treatment, comparing to the control group, in the observation group the heart rate decreased (P<0.05), the mean arterial pressure and the central venous pressure increased (P<0.05), the serum levels of super oxide dismutase and glutathione peroxidase increased (P<0.05) and the serum levels of malondialdehyde, tumor necrosis factor α, interleukin-6, C-reactive protein decreased (P<0.05). In treatment of SAP, ilaprazole combined with somatostatin can enhance the curative efficacy and decrease the oxidative stress and the inflammatory response in patients. In addition, it cannot increase the adverse reactions, with good safety.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study on the effects of doxycycline, nalidixic acid and meropenem on Escherichia coli in inducing urinary tract infections. 多西环素、萘啶酸和美罗培南对诱发尿路感染的大肠埃希菌影响的比较研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Noor Us Saba Mansoor, Huma Dilshad, Javeria Sheikh, Sumaira Khadim, Sobia Kamran, Syeda Hina Zaidi

{"title":"A comparative study on the effects of doxycycline, nalidixic acid and meropenem on Escherichia coli in inducing urinary tract infections.","authors":"Noor Us Saba Mansoor, Huma Dilshad, Javeria Sheikh, Sumaira Khadim, Sobia Kamran, Syeda Hina Zaidi","doi":"","DOIUrl":"","url":null,"abstract":"Urinary tract infections are widely recognized as prevalent bacterial infections frequently encountered in both hospital and community settings. The most common gram-negative bacterial pathogen in humans, extra-intestinal pathogenic Escherichia coli, causes these diseases. A retrospective cross-sectional study in Karachi, Pakistan examined Escherichia coli's susceptibility to doxycycline, nalidixic acid and meropenem. One hundred isolates of Escherichia coli from urine samples of patients were collected. The Kirby Bauer disc diffusion testing method was used following CLSI guidelines. The results showed variability because of differences in patient's gender and age. 84 out of 100 samples were of females and 16 samples were of males. Infection prevalence by age showed that 15% of isolates were from children (0-12 years), 2% from adolescents (13-18 years), 52% from adults (19-59 years) and 31% from seniors. This study concluded that females and adults (aged 19-59 years) are at highest risk of prevalence. Meropenem is a potential antibiotic choice for urinary tract infections due to its demonstrated 100% susceptibility. However, in light of increasing resistance trends, the administration of doxycycline and nalidixic acid should be reserved until antimicrobial susceptibility testing has been conducted. The study ensures that antibiotics are used judiciously and effectively in combating urinary tract infections while minimizing the risk of further antimicrobial resistance development.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and antioxidant studies of silver nanoparticles formulated from Erythrina senegalensis stem bark extract. 用塞内加尔桉树茎皮提取物配制的银纳米粒子的抗菌和抗氧化研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Emmanuel Mshelia Halilu, Collins Ovenseri Airemwen, Emmanuel Omolan

{"title":"Antibacterial and antioxidant studies of silver nanoparticles formulated from Erythrina senegalensis stem bark extract.","authors":"Emmanuel Mshelia Halilu, Collins Ovenseri Airemwen, Emmanuel Omolan","doi":"","DOIUrl":"","url":null,"abstract":"Erythrina senegalensis, belongs to the family of Fabaceae and it has been used traditionally to treat microbial infections and diabetes mellitus. The aim of this study was to formulate silver nanoparticles (AgNPs) from the methanol stem bark extract of Erythrina senegalensis and to evaluate the antibacterial and antioxidant effects of the nanoparticles. The methanol extract was screened qualitatively for the presence of tannins, alkaloids, saponins and flavonoids using standard protocols. The silver nanoparticles were synthesized using green method and the particles were evaluated using scanning electron microscope (SEM) and X-Ray diffraction (XRD). The percent inhibition effects of the AgNPs and extract were analyzed using hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. The antibacterial effect of the methanol and the AgNPs were determined by disk diffusion method. The phytochemical screening revealed the presence of tannins and flavonoids. The DPPH assay revealed IC50 values of 3.60, 2.25 and 1.75mg/mL for the silver nanoparticles, methanol extract and ascorbic acid respectively. The findings from this study indicated that the extracts contain some secondary metabolites such as flavonoids which may be responsible for the bio-reduction of silver ion (Ag+) to AgNPs as well as the antimicrobial and antioxidant activities.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The encapsulation rate and pH sensitivity of arsenic were improved in liposome nanoparticles by the calcium acetate gradient method. 醋酸钙梯度法提高了砷在脂质体纳米颗粒中的包封率和对 pH 值的敏感性。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Hengwu Xu, Yuhang Fan, Peng Wang, Chao Ying, Wendong Yao

{"title":"The encapsulation rate and pH sensitivity of arsenic were improved in liposome nanoparticles by the calcium acetate gradient method.","authors":"Hengwu Xu, Yuhang Fan, Peng Wang, Chao Ying, Wendong Yao","doi":"","DOIUrl":"","url":null,"abstract":"The study proposed improving the arsenic encapsulation efficiency (EE) in liposomes and make it pH responsive. Liposomes were prepared using the ethanol injection method (EIM), thin film dispersion method (TFM) and CAGM with sodium arsenite (NaAsO2). The orthogonal experimental was used to optimize the preparation conditions of the CAGM. The arsenic-carrying liposomes were characterized by polydispersity index (PDI), transmission electron microscopy (TEM), in vitro release experiments and inductively coupled plasma emission spectrum (ICP). The toxicity was investigated by rat glioma cells (C6) and human brain micro vascular endothelial cells (HBMEC). The results indicated that the CAGM can effectively improve the EE of NaAsO2 and has a pH response compared with EIM and TFM. The size of nanoparticles prepared by CAGM was 118.8 ±56.67 nm, the arsenic EE was 54.3 ±9.82%, the drug loading rate was 7.13 ±0.72% (P <0.01), pH sensitivity was shown at pH 5.5. The optimal parameters of the CAGM were 3 mg NaAsO2, 5:1 egg phosphatidylcholine (EPC) to cholesterol (CHOL) and 240 mmol/L calcium acetate (CaAC2). The results showed that the CAGM has good biocompatibility and is one of the effective ways to improve the NaAsO2 encapsulation rate and pH response in liposome nanoparticles.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel, non-toxic chitosan modified with lysine to enhance buffer capacity for siRNA delivery. 一种用赖氨酸修饰的新型无毒壳聚糖，可增强 siRNA 输送的缓冲能力。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-07-01

Tianhui Liu, Mei Lin, Chengfei Zhao, Aizhu Lin

引用次数: 0