OTO Open最新文献

{"title":"Vietnamese SNOT-22 Validation: Prospective Cohort Study on Sinonasal Symptoms And Health-Related Quality of Life.","authors":"Minh P Hoang, Hien T T Doan, Minh H N Phan, Thinh Tran, Kachorn Seresirikachorn, Kornkiat Snidvongs","doi":"10.1002/oto2.70252","DOIUrl":"10.1002/oto2.70252","url":null,"abstract":"<p><strong>Objective: </strong>Chronic rhinosinusitis (CRS) is a prevalent inflammatory disorder of the upper airway that drives substantial healthcare burden and impairs health-related quality of life (HRQoL). This study aimed to translate and validate the Vietnamese version of the 22-item Sinonasal Outcome Test (SNOT-22), a widely used patient-reported outcome measure for CRS.</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>Tertiary academic center.</p><p><strong>Methods: </strong>The SNOT-22 was translated following a standardized forward-backward procedure. Reliability, validity, and responsiveness were assessed in 110 participants (69 CRS patients, 31 controls). Among 52 surgical patients, questionnaires were administered preoperatively and at 1, 3, and 6 months postoperatively. Correlations were examined with endoscopic, radiologic, symptom severity, and disease-specific measures.</p><p><strong>Results: </strong>The Vietnamese SNOT-22 demonstrated excellent internal consistency (Cronbach's <i>α</i> = 0.95), test-retest reliability (intraclass correlation coefficient = 0.94). Postoperative stability between 1 and 3 months was high (<i>r</i> = 0.78). Validity was demonstrated by clear discrimination between CRS patients and controls (<i>P</i> < .01) and across HRQoL levels (<i>P</i> = .01). No significant score difference was found between CRS phenotypes with or without nasal polyps. The SNOT-22 significantly correlated weakly with the modified Lund-Kennedy score, strongly with the VAS symptom score, and showed no correlation with the Lund-Mackay score. Responsiveness was robust, with significant postoperative improvement (<i>P</i> < .01) and a large effect size of 1.81 at 6 months.</p><p><strong>Conclusion: </strong>The Vietnamese SNOT-22 is a reliable, concise, and responsive instrument for assessing HRQoL in CRS patients and can be recommended for both clinical practice and research in Vietnamese-speaking populations.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70252"},"PeriodicalIF":1.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotizing Otitis Externa: Insights From a Nationwide Database on In-Hospital Outcomes and Characteristics.","authors":"Noa Berick, Golda Grinblat, Majd Hajouj, Itzhak Braverman, Isaac Shochat","doi":"10.1002/oto2.70253","DOIUrl":"10.1002/oto2.70253","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate demographic and hospital-related factors associated with length of stay (LOS) in patients hospitalized with necrotizing otitis externa (NOE).</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Nationwide Inpatient Sample (NIS), 2017 to 2019.</p><p><strong>Methods: </strong>Patients with a primary diagnosis of NOE were identified from the NIS. Linear regression and additional statistical analyses were performed to assess associations between LOS and variables including age, gender, race, socioeconomic status, hospital type, and comorbidities such as diabetes.</p><p><strong>Results: </strong>A total of 3580 patients with NOE were included. Increased age was significantly associated with longer LOS (<i>P</i> < .001). Black patients had longer hospitalizations compared to white patients (6.1 vs 4.4 days, <i>P</i> < .001). Women were hospitalized at a younger age than men (54 vs 60 years, <i>P</i> < .001), while men had longer LOS (5.3 vs 4.6 days, <i>P</i> = .033). Patients treated in teaching hospitals and those without diabetes had longer LOS. Socioeconomic disparities were evident, with Black patients more likely to reside in lower-income ZIP code areas (<i>χ</i>² = 19.4, <i>df</i> = 3, <i>P</i> < .001). The number of diagnoses did not differ significantly between Black and non-Black patients (<i>t</i> = 0.758, <i>df</i> = 697, <i>P</i> = .449).</p><p><strong>Conclusion: </strong>Elderly, male, Black patients and those treated at teaching hospitals tend to have longer hospitalizations for NOE. Women and non-diabetic patients are admitted at younger ages. These findings identify demographic and hospital-related factors that are associated with LOS and support the need for additional research to clarify the factors underlying these disparities.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70253"},"PeriodicalIF":1.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- Versus Long-Term Hearing Preservation and Speech Recognition Outcomes in Precurved and Straight Electrode Arrays.","authors":"Lily V Den Hartog, Andrew W Liu, Divya A Chari","doi":"10.1002/oto2.70254","DOIUrl":"10.1002/oto2.70254","url":null,"abstract":"<p><strong>Objective: </strong>Compare audiologic outcomes between precurved and straight electrode arrays in cochlear implant (CI) recipients while controlling for age and preoperative hearing in a large cohort.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Methods: </strong>Adult CI recipients who underwent surgery from 2018 to 2025 with Cochlear Americas slim modiolar CI532/632 (precurved) or slim straight CI522/622 (straight) electrode arrays were included. Preimplantation and postimplantation low-frequency pure tone average (LFPTA) in the short- (1- and 6-months) and long-term (≥12 months) and speech recognition testing (CNC, AzBio in quiet) at 1-, 3-, 6-, and 12-months postactivation were recorded. Hearing preservation (LFPTA shift) and speech recognition scores were evaluated using multivariate linear regression analysis.</p><p><strong>Results: </strong>One hundred seventy-two patients (190 ears) were included. 124 (65.3%) and 66 (34.7%) ears were implanted with a precurved or straight electrode, respectively. 47 (24.7%) ears had residual hearing (LFPTA ≤ 80) preoperatively. Precurved electrode recipients had significantly better hearing preservation compared to straight electrode recipients in the short-term (<i>F</i> = 4.016, <i>P</i> = .039), though this advantage diminished in long-term follow-up after controlling for age, sex, and preoperative LFPTA. CNC and AzBio scores were not significantly different between electrode arrays at any timepoint postimplantation.</p><p><strong>Conclusion: </strong>Precurved electrodes were associated with small but statistically significant greater hearing preservation in the short-term compared to straight electrodes, but this difference did not persist in the long-term. Speech recognition outcomes were similar for precurved and straight electrodes at all timepoints. These findings should be considered during preoperative decision-making for potential CI recipients.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70254"},"PeriodicalIF":1.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pooled Analysis of Sleep Outcomes After Treatment With Temperature-Controlled Radiofrequency in Nasal Airway Obstruction Patients.","authors":"Masayoshi Takashima, Ashwin Ananth, Paul T Hoff, Paul Schalch Lepe, Gavin Setzen, Maria V Suurna","doi":"10.1002/oto2.70250","DOIUrl":"10.1002/oto2.70250","url":null,"abstract":"<p><strong>Objective: </strong>To assess the long-term impact of temperature-controlled radiofrequency (TCRF) treatment on sleep-related symptoms in patients with nasal airway obstruction (NAO), including those with documented obstructive sleep apnea (OSA).</p><p><strong>Study design: </strong>Pooled analysis of prospective multicenter studies.</p><p><strong>Setting: </strong>Seven academic and 25 private otolaryngology sites.</p><p><strong>Methods: </strong>A pooled analysis of 345 adults across four prospective multicenter studies (PIVOTAL, VATRAC, SWELL, and AERWAY) from 7 academic and 25 private otolaryngology sites was conducted. Participants had severe-to-extreme NAO and received a single, office-based TCRF treatment targeting the nasal valve or septal swell body (SSB). Outcomes included sleep-related components of the Nasal Obstruction Symptom Evaluation (NOSE) scale, 22-item Sino-Nasal Outcome Test (SNOT-22) sleep domain, and Epworth Sleepiness Scale (ESS). Analyses included stratification by the presence or absence of OSA and linear regression.</p><p><strong>Results: </strong>TCRF treatment was associated with significant, durable improvements in sleep-related symptoms through 24 months. At 24 months, the \"Trouble Sleeping\" subcomponent of the NOSE score improved by -1.9 (95% CI, -2.0 to -1.7) points, a 64% improvement. SNOT-22 sleep domain scores declined by -9.0 (95% CI, -10.5 to -7.6) points, with more than 80% of participants achieving clinical improvement. Among those with excessive daytime sleepiness (ESS ≥ 10), ESS dropped by -8.3 (95% CI, -9.7 to -6.9), and the prevalence of sleepiness fell from 53.8% to 9.8%. Improvements were consistent across the OSA+ subgroup.</p><p><strong>Conclusion: </strong>Office-based TCRF therapy targeting the nasal valve and/or SSB is associated with clinically meaningful, durable improvements in sleep-related symptoms and daytime somnolence in NAO patients, including a subset of those with documented OSA.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70250"},"PeriodicalIF":1.6,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Medicare Office-Based Procedures for Chronic Rhinitis and Nasal Obstruction.","authors":"Seth S Jeong, Mark Arnold","doi":"10.1002/oto2.70219","DOIUrl":"10.1002/oto2.70219","url":null,"abstract":"<p><strong>Objective: </strong>To examine national trends in Medicare office-based procedures for chronic rhinitis and nasal obstruction, emphasizing minimally invasive interventions such as posterior nasal nerve (PNN) ablation and nasal valve repair with radiofrequency ablation.</p><p><strong>Study design: </strong>Retrospective longitudinal analysis of Medicare physician and provider utilization data from 2017 to 2023.</p><p><strong>Setting: </strong>Office-based procedural care across the United States.</p><p><strong>Methods: </strong>Current Procedural Terminology (CPT) codes 30117 (destruction of intranasal lesion), 30140 (inferior turbinate submucous resection), 31295 (maxillary balloon dilation), and 30802 (radiofrequency inferior turbinate reduction) were analyzed, focusing on office-based procedures. CPT 30117 served as a surrogate for PNN ablation and nasal valve repair using radiofrequency ablation. Annual service counts, beneficiaries, Medicare payments, total spending, provider-level adoption, geographic distribution, and early adopter patterns were analyzed. Linear regression evaluated trends over time (<i>P</i> < .05).</p><p><strong>Results: </strong>From 2017 to 2023, CPT 30117 services rose from 1009 to 11,409 (compound annual growth rate [CAGR] 49.8%), 30140 increased from 3218 to 5792 (CAGR 10.3%), 31295 slightly declined (10,3120 → 9180; CAGR -1.9%), and 30802 declined from 1353 to 863 (CAGR -7.2%). Spending grew sharply for 30117 ($0.41M → $5.08M; +1139%) and 31295 ($12.36M → $15.4M; +25%), modestly for 30140 ($0.89M → $1.05M; +18%), and declined for 30802 ($0.19M → $0.10M; -47%). Texas, Florida, and Arizona had concentrated utilization.</p><p><strong>Conclusion: </strong>In-office use of CPT 30117 has grown rapidly, outpacing other nasal procedures, reflecting the adoption of new PNN ablation and nasal airway remodeling devices. These trends underscore the need for ongoing evidence development, with further clarification anticipated following new device and procedure-specific coding.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70219"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric Measurements Inform Complete Concentric Collapse Status in Patients With Obstructive Sleep Apnea.","authors":"Jordan S Weiner, Eugene G Chio, Raj C Dedhia, Colin T Huntley, Michael J Hutz, Phillip Huyett, Daniel J Lee, Philip LoSavio, Ilya Perepelitsyn, Ryan J Soose, David T Kent","doi":"10.1002/oto2.70245","DOIUrl":"10.1002/oto2.70245","url":null,"abstract":"<p><strong>Objective: </strong>Hypoglossal nerve stimulation in the US requires drug-induced sleep endoscopy to exclude patients with complete concentric collapse. This is an expensive and time-consuming requirement. We hypothesized that supine pharyngeal width, and other demographic and polysomnographic variables would associate with complete concentric collapse.</p><p><strong>Study design: </strong>Prospective, multicenter cohort study.</p><p><strong>Setting: </strong>10 centers in the United States with experience selecting patients for and performing airway surgeries for sleep apnea including hypoglossal nerve stimulation implantation.</p><p><strong>Methods: </strong>600 patients meeting criteria for hypoglossal nerve stimulation underwent measurement of supine pharyngeal width and collection of demographic and polysomnographic data followed by drug-induced sleep endoscopy.</p><p><strong>Results: </strong>587 patients completed the study. Patients with complete concentric collapse had a higher body mass index (31.2 ± 3.2 vs 29.0 ± 3.4 kg/m², <i>P</i> < .001), larger neck circumference (45.5 ± 4.2 vs 40.6 ± 4.7 cm, <i>P</i> < .001), and lower supine pharyngeal width (19.4 ± 6.3 vs 21.8 ± 6.5 mm; <i>P</i> = .008) than patients without complete concentric collapse.</p><p><strong>Conclusion: </strong>Body mass index, neck circumference, and supine pharyngeal width all associate with complete concentric collapse and could potentially be used to determine hypoglossal nerve stimulation candidacy instead of drug-induced sleep endoscopy for most patients thereby reducing both time and cost. (ClinicalTrials.gov NCT05428839: https://clinicaltrials.gov/study/NCT05428839?term=Inspire%20Medical%20systems%20predictor&rank=1).</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70245"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Social Vulnerability Index and Severity of Pretreatment Swallowing Dysfunction for Oropharyngeal Cancer Patients.","authors":"Prerita Pandya, Shravan Asthana, Hannah Soltani, Alex Clain, Kirsten B Burdett, Laila A Gharzai, Urjeet Patel, Sandeep Samant, Andrew P Stein, Bonnie Martin-Harris, Katelyn O Stepan","doi":"10.1002/oto2.70242","DOIUrl":"10.1002/oto2.70242","url":null,"abstract":"<p><strong>Objective: </strong>Given growing recognition that social determinants of health influence cancer outcomes and functional status, we sought to examine associations between social vulnerability, measured by CDC's Social Vulnerability Index (SVI), and pretreatment swallowing function, quantified by Modified Barium Swallow Impairment Profiles (MBSImP), in patients with oropharyngeal squamous cell carcinoma (OPSCC).</p><p><strong>Study design and setting: </strong>Retrospective analysis of patients at Northwestern University with pretreatment MBSImP studies.</p><p><strong>Methods: </strong>MBSImP oral total (OT) and pharyngeal total (PT) scores were calculated, and SVI assigned to patient residential address at diagnosis. Associations between overall SVI, SVI subcomponents, clinical variables, and OT and PT scores were assessed using univariable and multivariable linear regression.</p><p><strong>Results: </strong>149 OPSCC patients with median age 63 years; 83.9% were male, 89.9% White, and 91.9% p16+. On univariable analysis, SVI was significantly associated with higher (worse) OT (<i>β</i> = 3.3; 95% CI: 1.8, 4.8; <i>P</i> < .001) and PT scores (<i>β</i> = 3.6; 95% CI: 0.75, 6.4; <i>P</i> = .013). After multivariable adjustment, SVI remained independently associated with increased OT scores (<i>β</i> = 2.3; 95% CI: 0.36, 4.2; <i>P</i> = .020); PT impairment was independently predicted by tumor subsite (tonsil vs. base of tongue: <i>β</i> = -1.8; 95% CI: -3.4, -0.28; <i>P</i> = .021). All four SVI domains were significantly linked to OT in univariable models.</p><p><strong>Conclusion: </strong>Social vulnerability independently predicts oral-phase swallowing impairment in OPSCC patients, while tumor subsite primarily determines pharyngeal swallowing impairment. These findings highlight the need to consider social determinants in pretreatment assessment, as well as further research to clarify how social determinants impact swallowing outcomes to identify effective, targeted interventions for high-risk groups.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70242"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications Associated With Polycaprolactone (PCL) Use in Septorhinoplasty: A Systematic Review and Meta-Analysis.","authors":"Panutas Piyananthasomdee, Minh P Hoang, Kachorn Seresirikachorn, Witsanu Jullamusi, Prapitphan Charoenlux","doi":"10.1002/oto2.70248","DOIUrl":"10.1002/oto2.70248","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the complications associated with polycaprolactone (PCL) use in septorhinoplasty.</p><p><strong>Data sources: </strong>OVID EMBASE, OVID MEDLINE, SCOPUS, and PubMed.</p><p><strong>Review methods: </strong>Studies reporting complications related to PCL in septorhinoplasty were included. Primary outcomes encompassed complications including tip deformity/warping, stiffness, deviation, infection, protrusion/extrusion, skin complications, epistaxis, and revision/reoperation. Subgroup analyses were conducted based on the type of operation, approach, surgery, graft, and material used.</p><p><strong>Results: </strong>A total of 13 studies, including 1194 patients, were analyzed. The pooled mean proportion of complications was relatively low, ranging from 0% to 0.72% (deviation 0% [95% CI -0.00 to 0.01], skin complications 0% [95% CI -0.00 to 0.00], infection 0.01% [95% CI 0.00-0.01], protrusion/extrusion 0.01% [95% CI 0.00-0.01], tip decrease/warping 0.02% [95% CI -0.00 to 0.04], revision/reoperation 0.03% [95% CI 0.02-0.03], epistaxis 0.07% [95% CI -0.06 to 0.21], and stiffness 0.72% [95% CI 0.59-0.85]). Subgroup analyses showed no statistically significant differences in complication based on operation type or graft type for tip decrease/warping (<i>P</i> = .70, <i>P</i> = .54), deviation (<i>P</i> = .16, <i>P</i> = .37), infection (<i>P</i> = .26, <i>P</i> = .68), protrusion/extrusion (<i>P</i> = .25, <i>P</i> = .73), skin complications (<i>P</i> = .25 for graft type), and revision/reoperation (<i>P</i> = .97, <i>P</i> = .99). Subgroup analysis by type of surgical approach (open, endonasal), type of procedure (primary, revision), and type of material (PCL, PCL combined with cartilage) could not be performed due to limitations in the original data.</p><p><strong>Conclusion: </strong>PCL appears to demonstrate acceptable short- to mid-term safety in septorhinoplasty. However, long-term and comparative data are needed to better define its role.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70248"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Alpha1-Antitrypsin Demonstrated Protective Effects Against Auditory Impairment in Murine Model of Noise-Induced Hearing Loss.","authors":"Benyamin M Kaminer, Sabri El-Saied, Ismael Abu Freh, Amit Amar, Oren Ziv, Daniel M Kaplan, Eli C Lewis","doi":"10.1002/oto2.70238","DOIUrl":"10.1002/oto2.70238","url":null,"abstract":"<p><strong>Objective: </strong>The pathophysiology of noise-induced hearing loss (NIHL) encompasses excessive inflammation, tissue damage, production of reactive oxygen species, and apoptotic processes, culminating in irreversible damage to hair cells. Currently, no clinical interventions are available to mitigate this condition. Alpha1-antitrypsin (AAT) is a circulating molecule with tissue-protective properties that increases during inflammatory states and facilitates the resolution of inflammation. Transgenic mice expressing elevated levels of human AAT have demonstrated enhanced tissue repair in various in vivo models, including restoration of vestibular function following inner ear trauma. We hypothesized that the transgenic overexpression of human AAT would offer protection against permanent threshold shifts following noise exposure in mice, as compared to wild-type controls.</p><p><strong>Study design: </strong>A murine model of NIHL.</p><p><strong>Setting: </strong>Laboratory study.</p><p><strong>Methods: </strong>Wild-type C57BL/6 and transgenic mice expressing human AAT (n = 5 per group) were exposed to broadband noise at a sound pressure level of 100 dB SPL for 2 hours. Auditory brainstem responses were measured.</p><p><strong>Results: </strong>hAAT mice showed a greater threshold shift at 24 hours but near-complete recovery by Day 7, unlike WT mice that developed a permanent threshold shift.</p><p><strong>Conclusions: </strong>hAAT promotes recovery after acoustic trauma, suggesting a potential therapeutic role in NIHL. WT and hAAT groups had similar baseline thresholds. At 24 hours postnoise exposure, hAAT mice exhibited a greater threshold shift than WT mice. By Day 7, hAAT thresholds had nearly recovered to baseline, whereas WT thresholds remained elevated, consistent with permanent hearing loss. Further research is required to elucidate the protective effects of AAT on the inner ear.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70238"},"PeriodicalIF":1.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone Adapters for Endoscopy: Current Use Among US Otolaryngology Residency Programs.","authors":"Soraya Abdul Hadi Martínez, Clariliz Munet Colón, Javier Antonio Vilá Ortiz, Mario González Carbonell, Edgar Del Toro Diez, Jeamarie Pascual Marrero","doi":"10.1002/oto2.70205","DOIUrl":"10.1002/oto2.70205","url":null,"abstract":"<p><strong>Objective: </strong>Smartphone adapters for flexible nasopharyngolaryngoscopy provide an accessible means for video documentation, enhancing both resident education and patient care. This study evaluates the current utilization of smartphone adapters for endoscopy among Otolaryngology Residency Programs in the United States.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>ACGME-accredited Otolaryngology Residency Programs.</p><p><strong>Methods: </strong>A 14-question survey was distributed to ACGME-accredited Otolaryngology Residency Programs during 2023. Responses regarding smartphone adapter use, training-level differences, barriers, and perceived benefits were analyzed using descriptive statistics.</p><p><strong>Results: </strong>A total of 115 residents from 27 states and Puerto Rico responded, with 62% being upper-level residents (PGY 3-5). Only 44% of respondents reported using smartphone adapters for endoscopy. The most cited barrier was lack of awareness (53%), followed by unavailability in residency programs (19%) and cost (11%). Among users, the primary reasons for adoption included video documentation for senior discussion (100%), patient education (63%), and airway handoffs (57%). The emergency room was the most common setting (100%), where 90% of residents lacked access to video endoscopic towers. The principal procedures performed with adapters were flexible laryngoscopy (100%) and nasal endoscopy (82%). Most residents reported using the Endoscope-i (41%) or Storz Smart Endoscope (23%), while a minority (4%) used 3-D printed models. Nearly all users (98%) considered smartphone adapters to be valuable for communication, case discussion, and clinical decision-making.</p><p><strong>Conclusion: </strong>Smartphone endoscopy adapters remain underutilized in Otolaryngology residency training. Given their educational and clinical benefits, formal integration into residency training programs may enhance patient care, resident learning, and interspecialty communication.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70205"},"PeriodicalIF":1.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}