OTO Open最新文献

{"title":"Otolaryngology Provider Distribution Disparities in Pennsylvania.","authors":"Edra K Ha, Natasha Mayer, Eugene Kim, Katie M Carlson, Angela L Mazul","doi":"10.1002/oto2.70236","DOIUrl":"10.1002/oto2.70236","url":null,"abstract":"<p><strong>Objective: </strong>To assess the distribution of otolaryngology providers within Pennsylvania.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>State of Pennsylvania.</p><p><strong>Methods: </strong>Otolaryngologists in Pennsylvania were analyzed based on their associated state Area Deprivation Indexes (ADIs) and Rural-Urban Commuting (RUCA) Codes, as determined by census tract data.</p><p><strong>Results: </strong>Of 563 otolaryngology providers identified in Pennsylvania, 477 (83.7%) had office addresses with available RUCA codes and 446 (79.2%) with associated ADI measures. Providers were predominantly located in urban settings, with 466 (93.5%) reporting a primary clinic address in a metropolitan area (RUCA 1-3) and 25 (5.2%) in a micropolitan area (RUCA 3-6). Notably, only 4 (0.8%) providers had primary clinic addresses in small towns (RUCA 7-9) and 2 (0.4%) in rural areas (RUCA 10). Similarly, 171 (38.3%) of providers were situated in areas with an ADI in the top 2 deciles (1-2), while only 56 (12.6%) had clinic addresses in deciles 9-10 (most deprived areas).</p><p><strong>Conclusion: </strong>Pennsylvania faces disparities in access to otolaryngology providers based on socioeconomic and urban-rural workforce distribution.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70236"},"PeriodicalIF":1.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Complete Spontaneous Hearing Recovery in a Pediatric Chemotherapy Patient-A Case Report.","authors":"Mihai A Bentan, Aaron Tucker, Meghan Nemeth, Daniel H Coelho","doi":"10.1002/oto2.70243","DOIUrl":"10.1002/oto2.70243","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70243"},"PeriodicalIF":1.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Thyroid Gland Volume and Postoperative Hypothyroidism Following Hemithyroidectomy.","authors":"Mayas Arraf, Alaa Safia, Adi Sharabi-Nov, Moanes Awad, Yaniv Avraham, Ohad Ronen, Shlomo Merchavy","doi":"10.1002/oto2.70239","DOIUrl":"10.1002/oto2.70239","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the proportion of resected thyroid tissue or the residual lobe volume predicts postoperative hypothyroidism following hemithyroidectomy.</p><p><strong>Study design: </strong>Multicenter retrospective cohort study.</p><p><strong>Setting: </strong>Ziv Medical Center and Galilee Medical Center, Israel.</p><p><strong>Methods: </strong>The study included 134 adult patients who underwent hemithyroidectomy between 2017 and 2024. Patients with preexisting hypothyroidism or malignant histopathology were excluded. Preoperative thyroid gland volumes were measured by computed tomography (CT) and correlated with serum thyroid hormone profiles (T3, T4, and TSH) obtained preoperatively, and at 1 and 6 months postoperatively. Associations between thyroid volume parameters and postoperative hypothyroidism were analyzed statistically.</p><p><strong>Results: </strong>Postoperative hypothyroidism developed in 29.1% of patients, within the first postoperative month. Affected patients exhibited significantly higher baseline TSH levels than euthyroid counterparts (3.0 vs 1.4 μIU/mL, <i>P</i> < .001). No significant correlation was found between postoperative thyroid function and total gland volume, resected lobe volume, or residual-to-total volume ratio. At 6 months, only 12% of patients remained hypothyroid, suggesting partial recovery of thyroid function in the remaining lobe.</p><p><strong>Conclusion: </strong>Neither the extent of resection nor the residual thyroid volume predicted postoperative hypothyroidism. These findings imply that factors beyond gland size-such as preoperative functional reserve or intrinsic thyroid health-may play a more decisive role in maintaining postoperative endocrine stability. Identifying these predictors could enhance patient selection, risk stratification, and postoperative follow-up.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70239"},"PeriodicalIF":1.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Recurrence Risk of Human Papillomavirus-Related Pharyngeal Papilloma: A Retrospective Study.","authors":"Ryohei Asai, Hiroumi Matsuzaki, Kiyoshi Makiyama, Takeshi Oshima","doi":"10.1002/oto2.70244","DOIUrl":"10.1002/oto2.70244","url":null,"abstract":"<p><strong>Objective: </strong>The association between pharyngeal papilloma and human papillomavirus (HPV) remains unclear. Although previous studies have suggested that HPV involvement is unlikely, we encountered HPV-positive cases, particularly in patients with multiple lesions, malignancy, or recurrence. This study aimed to clarify the relationship between HPV infection and clinicopathological features of pharyngeal papilloma, including recurrence and malignant transformation.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Setting: </strong>Department of Otolaryngology-Head and Neck Surgery, Nihon University Hospital, a single tertiary referral center in Tokyo, Japan.</p><p><strong>Methods: </strong>We retrospectively reviewed HPV-DNA test results and clinical data from 69 patients with pharyngeal papilloma who underwent surgical resection between August 2006 and September 2018. Koilocytosis was histologically assessed, and associations between HPV status and recurrence, multiplicity, and malignant transformation were analyzed.</p><p><strong>Results: </strong>Among 69 patients, 5 (7.2%) were HPV-positive, including four (5.8%) low-risk types (6, 11) and 1 (1.4%) high-risk type (16). Koilocytosis was observed in 88% of cases. HPV-positive cases had higher recurrence, multiplicity, and malignant transformation rates compared with HPV-negative cases.</p><p><strong>Conclusion: </strong>HPV DNA was detected in 7.2% of cases. HPV-positive papillomas showed higher recurrence and malignanct transformation rates. Detection of HPV DNA may serve as a prognostic factor, and koilocytosis in HPV-negative cases may reflect prior transient HPV infection.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70244"},"PeriodicalIF":1.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Esophageal Diverticulum Repair by Otolaryngologists and General Surgeons Over Time: A NSQIP Analysis.","authors":"Nour Abdel-Azim, Emma R Thompson, Om B Tripathi, Kenneth Yan","doi":"10.1002/oto2.70237","DOIUrl":"10.1002/oto2.70237","url":null,"abstract":"<p><strong>Objective: </strong>To assess comorbidities, complication rates, and other metrics for open esophageal diverticula repair performed by either otolaryngologists or general surgeons over time.</p><p><strong>Study design: </strong>Retrospective database study.</p><p><strong>Setting: </strong>National Surgery Quality Improvement Database (NSQIP).</p><p><strong>Methods: </strong>The NSQIP database was queried for cases logged by either otolaryngologists (ENT) or general surgeons (GS) from 2005 to 2020 with CPT code 43130. Preoperative characteristics, postoperative outcomes (length of stay, complications, discharge destination), and operative time were compared between specialties and over time using SPSS and R, with significance set at 0.05.</p><p><strong>Results: </strong>Preoperatively, GS patients were more likely to have histories of dyspnea (<i>P</i> = .004), pneumonia (<i>P</i> < .001), and >10% body weight loss within 6 months of surgery (<i>P</i> = .008). While there was no significant difference in rates of postoperative complications, patients undergoing repair by ENT had shorter hospital stays, were more likely to be discharged home, and their surgeries were more frequently outpatient and elective (all <i>P</i> < .001). Temporal analysis demonstrated a significant year-over-year decrease in length of stay across all cases (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>Our study suggests that the differences in length of hospital stay and discharge settings may be at least partially attributed to the fact that GS patients were admitted with more preoperative comorbidities. This could reflect hospital staffing, or endoscopic management of sicker patients by ENT. Closer comparison of postoperative management strategies may further elucidate the difference in outcomes.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70237"},"PeriodicalIF":1.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deprivation Indices in Head and Neck Cancer: A Scoping Review.","authors":"Abbey L Landini, Sydney A Fleishman, Shravan Asthana, Asher Park, Molly Beestrum, Katelyn O Stepan","doi":"10.1002/oto2.70235","DOIUrl":"10.1002/oto2.70235","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review aims to characterize the methodology and findings of head and neck cancer (HNC) literature utilizing deprivation indices.</p><p><strong>Data sources: </strong>Studies published in MEDLINE (PubMed), Embase (Elsevier), Cochrane Database of Systematic Reviews (Wiley), Cochrane Central Register of Controlled Trials (Wiley), Scopus (Elsevier), and Web of Science (Clarivate).</p><p><strong>Review methods: </strong>A PRISMA-ScR-based protocol was registered with the Open Science Framework (ID: vhm2n). Two independent reviewers and an unbiased moderator conducted study selection and characterization. Results were narratively synthesized to identify thematic trends in index utilization, outcome disparities, and methodological variability.</p><p><strong>Results: </strong>Of the 5126 unique abstracts identified, 45 articles were included. Studies were mostly retrospective national database studies (n = 24, 53.3%) published after 2020 (n = 41, 91.1%). The Area Deprivation Index (ADI) was the most frequently reported deprivation index (n = 16, 35.6%) followed by Social Vulnerability Index (SVI) (n = 14, 31.1%), typically analyzed as continuous variables (n = 20, 44.4%). The most common primary outcomes were survival (n = 17, 37.8%), surveillance period (n = 12, 26.7%), and tumor characteristics at presentation (n = 7, 15.6%). A significant association between greater deprivation and worse primary outcomes was reported in 39 studies (90.3%), including 13 of 14 SVI studies (92.9%) and 11 of 16 ADI studies (68.8%).</p><p><strong>Conclusions: </strong>While deprivation indices are increasingly used in HNC research, their application remains inconsistent across study design, index selection, and reporting. Deprivation indices have utility in HNC research and should be further studied to better standardize their use for clinical application and interpretation.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70235"},"PeriodicalIF":1.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Hypoglossal Nerve Stimulation Versus Continuous Positive Airway Pressure in Obstructive Sleep Apnea.","authors":"Amala Nayak, Iman Adibi, Alyssa Calder, Arman Saeedi, Aaron Tucker, Ryan Nord","doi":"10.1002/oto2.70240","DOIUrl":"10.1002/oto2.70240","url":null,"abstract":"<p><strong>Objectives: </strong>Obstructive sleep apnea (OSA) is linked to cardiovascular, metabolic, and neuropsychiatric morbidity. Continuous positive airway pressure (CPAP) remains first-line therapy, but poor adherence limits effectiveness. Hypoglossal nerve stimulation (HNS) is an emerging alternative for CPAP-intolerant patients. This study compared clinical outcomes between HNS and CPAP in OSA patients.</p><p><strong>Study design: </strong>Retrospective Cohort Study.</p><p><strong>Setting: </strong>TriNetX Research Network.</p><p><strong>Methods: </strong>We identified adults with OSA who underwent HNS implantation or initiated CPAP therapy, with 2 years of follow-up. Propensity score matching (n = 3525 per group) balanced baseline demographics and comorbidities. Acute cardiovascular, respiratory, and metabolic outcomes were assessed from 30 days posttreatment to 2 years. A similar analysis was performed to compare health outcomes of HNS and uvulopalatopharyngoplasty (UPPP) surgery without future CPAP use.</p><p><strong>Results: </strong>The HNS cohort had significantly lower odds of stroke (odds ratio [OR] 0.626, <i>P</i> = .0085), myocardial infarction (OR 0.612, <i>P</i> < .0108), atrial fibrillation/flutter (OR 0.594, <i>P</i> < .0001), hypertensive crisis (OR 0.456, <i>P</i> < .0274), pulmonary embolism (OR 0.209, <i>P</i> < .0001), ventricular tachycardia (OR 0.349, <i>P</i> = .0001), COPD exacerbation (OR 0.270, <i>P</i> < .0001), acute kidney injury (OR 0.283, <i>P</i> < .0001), ED visit (OR 0.457, <i>P</i> < .0001), hospitalization (OR 0.419, <i>P</i> < .0001), acute heart failure (OR 0.198, <i>P</i> < .0001), heart failure exacerbation (OR 0.221, <i>P</i> < .0001), acute respiratory failure (OR 0.172, <i>P</i> < .0001), and pneumonia (OR 0.255, <i>P</i> < .0001). Daytime sleepiness was more common in the HNS group (OR 2.019, <i>P</i> < .0001). HNS and UPPP cohorts displayed largely similar health outcomes.</p><p><strong>Conclusion: </strong>HNS may offer systemic benefits and reduce healthcare burden compared to CPAP. Future studies should incorporate adherence data and cost-effective analyses to guide treatment.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70240"},"PeriodicalIF":1.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otolaryngology Surgeon-Scientists: The Road Less Traveled.","authors":"Tonya Aaron, Janice Huang, Soumil Prasad, Pavan S Krishnan, Garrett Forman, Lucienna Wolf, Eric Sokhn, Taylor Kring, Bryan Souza, Christine T Dinh, Elizabeth J Franzmann, Xue Z Liu","doi":"10.1002/oto2.70228","DOIUrl":"10.1002/oto2.70228","url":null,"abstract":"<p><strong>Objective: </strong>Surgeon-Scientists in Otolaryngology-Head and Neck Surgery (OHNS) are critical to advancing clinical care through scientific innovation. However, extended training duration and challenges in research funding acquisition continue to hinder career advancement.</p><p><strong>Study design: </strong>Cross-sectional cohort study.</p><p><strong>Setting: </strong>Analysis of publicly available NIH RePORTER data and national survey of NIH-funded OHNS faculty across US academic medical institutions. Survey data was collected between October and December 2024.</p><p><strong>Methods: </strong>We identified NIH-funded OHNS faculty as of September 2024 using the NIH RePORTER database. We examined time to initial R01-equivalent funding and grant diversity by degree types (MD, PhD, or dual-degree). A survey was administered to the OHNS faculty to evaluate their training experiences, research productivity, and funding mechanisms.</p><p><strong>Results: </strong>PhD faculty comprised the largest proportion of NIH-funded OHNS investigators (52%) and had greater grant diversity than MD and dual-degree counterparts (<i>P</i> < .0001). Furthermore, PhDs secured R01-equivalent grants earlier than MDs and dual-degree holders (7.5 vs 9.5 years posttraining, <i>P</i> = .04). However, MD and dual-degree faculty were more likely to obtain K awards and transition to R01 funding (<i>P</i> < .0001). Participation in T32/R25 residency programs was associated with a 2.5-year reduction in time to R01-equivalent grant (<i>P</i> = .037). Basic science researchers were 4 times more likely to obtain K awards (<i>P</i> = .04).</p><p><strong>Conclusion: </strong>While OHNS PhD faculty attain early and diverse funding, structured training programs and engagement in basic science research significantly enhance MD-degree faculty funding success. This study highlights institutional and training-level strategies that reduce the time to research independence and strengthen the OHNS surgeon-scientist pipeline.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70228"},"PeriodicalIF":1.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Dog Bite-Induced Facial Trauma: A Study From a Single Tertiary Care Center.","authors":"Andrew J Rothka, Marly Aziz, Katelyn P K Nguyen, F Jeffrey Lorenz, Heather K Schopper, Jessyka G Lighthall","doi":"10.1002/oto2.70233","DOIUrl":"10.1002/oto2.70233","url":null,"abstract":"<p><strong>Objective: </strong>Analyze demographic and clinical factors for patients presenting with dog bites to the face, head, or neck.</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Setting: </strong>Single tertiary care, level 1 trauma center.</p><p><strong>Methods: </strong>A retrospective chart review identified patients presenting for facial dog bite injuries from 2012 to 2023.</p><p><strong>Results: </strong>There were 906 patients with facial dog bites and 2061 injuries. Patients ranged from 0 to 91 years old with a median of 7 years, and 50.6% were female. The 2 most common causes for injury were playing with the dog (32.0%) or an unprovoked attack (17.3%). Family dogs were responsible for 61.3% of injuries. Pitbulls (22.4%), Labradors (10.5%), and German Shepherds (7.0%) were the most identified breeds. The cheeks (25.9%), lips (20.8%), and nose (9.0%) were most injured. Hospital admission was required in 17.0% of patients. Regarding management, 16.9% required operative repair, 65.9% were repaired at bedside, and 17.9% were managed conservatively. There were 878 patients prescribed intravenous or oral antibiotics (96.9%) with amoxicillin-clavulanate most frequently prescribed (62.7%). Of the 138 patients bit by dogs with outdated or unknown rabies vaccination status, 35.5% (n = 49) received a rabies vaccination, and 34.8% (n = 48) received rabies immunoglobulins. Of the 254 patients not current on tetanus vaccination, 78.7% (n = 200) received a booster.</p><p><strong>Conclusion: </strong>Dog bites to the head and neck are common injuries, with many patients requiring hospital admission and/or repair. Understanding the demographics of these injuries is important to identify physical and socioeconomic burdens of disease, gaps in adherence to protocols/guidelines, and areas of targeted education/preventative interventions.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70233"},"PeriodicalIF":1.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers & Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review & Meta-Analysis.","authors":"Jesse Siegel, William Adams, Kent Tadokoro, Veronica Drozdowski-Nuccio, Carol Bier-Laning","doi":"10.1002/oto2.70227","DOIUrl":"10.1002/oto2.70227","url":null,"abstract":"<p><strong>Objective: </strong>EGFR, cyclin D1, and Bcl-2 are proteins involved in different stages of tumorigenesis which have all been associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). In this systematic review and meta-analysis, we aim to measure the association of each protein with survival in HNSCC.</p><p><strong>Data sources: </strong>PubMed, Scopus, and Cochrane databases.</p><p><strong>Review methods: </strong>A systematic review of EGFR, cyclin D1, and Bcl-2 was conducted to determine the association between overexpression and survival in HNSCC. A weighted random-effects meta-analysis then measured pooled rates of overall, disease-free, and disease-specific survival for each protein.</p><p><strong>Results: </strong>Overexpression of EGFR was associated with worse overall mortality (HR = 1.52, <i>P</i> = .01), disease-related mortality (HR = 1.33, <i>P</i> = .02), and disease progression (HR = 1.99, <i>P</i> < .001). Overexpression of cyclin D1 was also associated with worse overall mortality (HR = 1.93, <i>P</i> < .001), disease-related mortality (HR = 1.57, <i>P</i> = .01), and disease-specific mortality (HR = 1.93, <i>P</i> = .01). The association between cyclin D1 and overall mortality also remained significant in papers examining only oropharynx cancer (HR = 2.66, <i>P</i> = .03). Overexpression of Bcl-2 was associated with worse overall mortality (HR = 1.92, <i>P</i> = .002).</p><p><strong>Conclusion: </strong>These findings support EGFR, cyclin D1, and Bcl-2 as biomarkers which portend worse prognosis in HNSCC. Further work will be needed to understand whether measurement of these proteins can be useful in tailoring treatment strategies, and whether they can be used as targets for novel therapies.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70227"},"PeriodicalIF":1.6,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}