OTO Open最新文献

{"title":"Middle Ear Lipochoristoma: A Rare Etiology of Hearing Loss.","authors":"Oliwia W Mlodawska, Karl W Doerfer","doi":"10.1002/oto2.70171","DOIUrl":"10.1002/oto2.70171","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70171"},"PeriodicalIF":1.8,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Water Irrigation Control Pleomorphic Adenoma Cell Growth Better Than Saline?","authors":"Nathaniel Neptune, Anuhya Kanchibhatla, Kelly R Magliocca, Brianna Brammer, Brendan L C Kinney, Vikash Kansal, Brian J Boyce, H Michael Baddour, Nicole C Schmitt","doi":"10.1002/oto2.70151","DOIUrl":"10.1002/oto2.70151","url":null,"abstract":"<p><strong>Objective: </strong>Sterile water irrigation is anecdotally noted as a method to lyse pleomorphic adenoma (PA) cells in the surgical bed and reduce the rate of recurrence if the tumor is ruptured. Surgeons often presume that the hypotonicity of water lyses residual tumor cells in the surgical bed; however, its effect on the viability of tumor cells remains unclear. This study aims to determine if water causes increased tumor cell death compared to saline.</p><p><strong>Study design: </strong>Prospective, laboratory-based study.</p><p><strong>Setting: </strong>Tertiary academic center.</p><p><strong>Methods: </strong>Surgically resected PA biospecimens were processed into a single-cell suspension and made into cell lines. Cells were exposed to sterile water or saline for 5, 10, or 15 minutes at room temperature (26°C), 37°C, or 44°C. After exposure, samples were analyzed for cell death by flow cytometry. Additional tumor cells were cultured after saline or water exposure to assess proliferation by tracking time to confluence. Three additional tumors were exposed to water or saline immediately after processing into cell suspensions, then cultured to determine time to confluence.</p><p><strong>Results: </strong>Exposure of PA cells to water induced cell death and prevented cell proliferation in vitro. Higher water temperatures and longer exposure times further reduced cell viability in one cell line.</p><p><strong>Conclusion: </strong>Study findings support the anecdotal claims that water irrigation can reduce the recurrence of PAs by increasing tumor cell lysis and suggest that the use of water irrigation might help to eliminate residual disease in the surgical bed. Further investigation is needed to confirm these results.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70151"},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a Modified Coblation Technique in Adenoidectomy: A Single-Blind Randomized Study.","authors":"Necdet Özçelik, Aslı Çakır, Elvin Alaskarov","doi":"10.1002/oto2.70162","DOIUrl":"10.1002/oto2.70162","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical and histopathological advantages of a modified technique-In Saline Coblation Adenoidectomy (ISCA)-over conventional coblation adenoidectomy (CCA) in pediatric patients, with respect to intraoperative efficiency, tissue preservation, and postoperative outcomes.</p><p><strong>Study design: </strong>This study was designed as a prospective, randomized, single-blind trial. Patients were randomly assigned to two groups, Group A \"CCA\" and Group B \"ISCA,\" each consisting of 25 children. Following the approval of the Medipol University Ethics Committee, patients who underwent adenoidectomy or adenotonsillectomy were included in the study.</p><p><strong>Setting: </strong>In Group A, adenoid tissue was ablated using the coblator's built-in irrigation system. For Group B, the nasopharynx and, partially, the oral cavity were continuously filled with saline solution delivered via the nasal passage. Excess fluid was aspirated from the mouth using a dedicated suction tip. This ensured that the endoscope and coblator tip remained immersed in saline throughout the procedure.</p><p><strong>Methods: </strong>A prospective, randomized, single-blind study was conducted involving 50 pediatric patients who underwent either conventional coblation (Group A, n = 25) or ISCA (Group B, n = 25). Operative time, intraoperative blood loss, postoperative pain scores, and wand-related issues were recorded. Histopathological analysis of adenoid specimens was performed to assess tissue integrity and thermal injury. Patients were followed for 6 to 18 months postoperatively for recurrence and complications.</p><p><strong>Results: </strong>ISCA significantly reduced operative time compared to CCA (24 ± 5.8 minutes vs 33 ± 8.5 minutes; <i>P</i> < .05). Wand tip clogging and secondary wand use were observed only in Group A. Histopathological analysis revealed greater epithelial preservation and reduced carbonization in Group B (92% vs 0%; <i>P</i> < .001). Postoperative complications such as transient velopharyngeal insufficiency and localized infection occurred exclusively in Group A, whereas no statistically significant difference in recurrence or residual tissue was noted between the groups.</p><p><strong>Conclusion: </strong>The ISCA technique offers clear clinical advantages over conventional coblation by improving procedural efficiency, minimizing collateral thermal injury, and eliminating wand-related delays. These findings support its wider adoption in high-volume pediatric otolaryngology settings.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70162"},"PeriodicalIF":1.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Outcomes of Head and Neck Cancer in Patients With Schizophrenia.","authors":"Talia A Wenger, Stephanie Wong, Shu-Yun Cheng, Liyang Tang, Daniel Kwon, Niels Kokot, Yang Chai, Uttam Sinha, Albert Y Han","doi":"10.1002/oto2.70164","DOIUrl":"10.1002/oto2.70164","url":null,"abstract":"<p><strong>Objective: </strong>We sought to determine the incidence and outcomes of head and neck cancer (HNC) among patients with schizophrenia.</p><p><strong>Study design: </strong>Cohort study utilizing TriNetX, a database containing millions of deidentified clinical records.</p><p><strong>Setting: </strong>Multicenter study utilizing records from 68 healthcare organizations.</p><p><strong>Methods: </strong>A cohort of patients with schizophrenia was analyzed for the annual incidence of HNC diagnosis between 2011 and 2021. TriNetX was queried for adult patients with HNC with and without schizophrenia (or long-term antipsychotic use, as a surrogate). Cohorts were 1:1 propensity-matched based on sociodemographic variables to produce matched cohorts of 25,077 patients each. Outcomes included mortality, recurrence in lymph nodes and lung, systemic treatment, failure to thrive, and hospice enrollment. Outcomes are reported as hazard ratio (HR; Cox proportional hazards model) and odds ratio (OR) with 95% CI.</p><p><strong>Results: </strong>Incidence of HNC in patients with schizophrenia peaked at 0.061% in 2012. HNC patients with schizophrenia have a significantly increased risk of mortality (HR 1.37, 95% CI 1.10-1.72), locoregional recurrence (OR 1.36, 95% CI 1.30-1.43), distant metastases to the lung (OR 1.72, 95% CI 1.59-1.87), chemotherapy (OR 4.26, 95% CI 3.88-4.69), radiation (OR 2.47, 95% CI 2.19-2.78), failure to thrive (OR 2.41, 95% CI 2.32-2.73), and hospice enrollment (OR 3.17, 95% CI 2.66-3.76) compared to HNC patients without schizophrenia.</p><p><strong>Conclusion: </strong>HNC patients with schizophrenia have a significant increase in risk of mortality, recurrence, and poor outcomes compared to those without schizophrenia. These findings support a renewed focus on ensuring safety nets for this vulnerable population to ensure appropriate cancer screening and care.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70164"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentiment Analysis of Cochlear Implants in the r/Cochlear Implants Subreddit.","authors":"Rose Dimitroyannis, Ethan Oliver, Ringo Leung, Rachel Nordgren, Terence E Imbery","doi":"10.1002/oto2.70165","DOIUrl":"10.1002/oto2.70165","url":null,"abstract":"<p><strong>Objective: </strong>Cochlear implants (CI) are surgical devices used for rehabilitation of sensorineural hearing loss. More individuals are receiving CIs as technology and surgical techniques improve and candidacy guidelines expand. Despite growing public awareness, CI utilization remains low. Understanding sentiment regarding these devices is important. Reddit is a text-based website wherein posters interact on specialized forums, \"subreddits.\" R/Cochlearimplants allows for unique CI sentiment analysis.</p><p><strong>Study design: </strong>A search was done from October 2024 to November 2024 on r/Cochlearimplants.</p><p><strong>Setting: </strong>Internet.</p><p><strong>Methods: </strong>Posts were sorted by highest engagement. Metadata regarding date, comments, and upvotes were collected. Sentiment was analyzed using TextBlob and VADER, Python library Natural Language Processing tools.</p><p><strong>Results: </strong>Four hundred and twenty unique posters made 1068 total entries. Entries spanned 2019 to 2024, the majority in 2024 (51%, n = 543). VADER found the majority of entries positive (n = 562, 52.9%) while TextBlob found the majority neutral (n = 928, 87%). Sentiment distribution over time was significantly different (<i>P</i> < .001), with more negative sentiment in 2024 than 2019 to 2023. Negative VADER entries had significantly higher word counts (<i>P</i> < .001). Positive VADER entries had higher upvotes (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>Sentiment regarding CI remains more nuanced than can be gleaned from this analysis, including cultural and ethical issues. This study demonstrates that sentiment on r/Cochlearimplants is generally neutral or positive, trending relatively more negative over time. This could suggest negativity towards CIs is growing with increased utilization. Awareness of online sentiment may help providers understand patient perspectives and dispel misinformation.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70165"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Scar on Quality of Life in Well-Differentiated Thyroid Carcinoma: A Systematic Review.","authors":"Aníbal Ariza, Alvaro Sanabria","doi":"10.1002/oto2.70155","DOIUrl":"10.1002/oto2.70155","url":null,"abstract":"<p><strong>Objective: </strong>Remote access techniques in thyroid surgery have been developed to improve cosmetic outcomes, based on the presumed impact of surgical scars on patients' quality of life (QoL). This systematic review aimed to evaluate the impact of surgical scars on the overall QoL of patients who have undergone thyroidectomy for low-risk thyroid carcinoma. The review focuses on the rank of scar-related QoL issues relative to other aspects assessed by validated QoL instruments.</p><p><strong>Data sources: </strong>MEDLINE, EMBASE, CENTRAL, LILACS, Google Scholar (no language or time restrictions).</p><p><strong>Review methods: </strong>A systematic review was conducted for original articles using validated QoL instruments with scar-related domains in thyroid cancer patients who had undergone OT. Study quality was assessed using the JBI critical appraisal tool for cross-sectional studies. Data were analyzed from 14 patient groups across 9 studies, representing 3658 patients.</p><p><strong>Results: </strong>In 12 of 14 samples, scar-related issues ranked lower than sixth place in QoL assessments, with 7 samples placing scar-related items at the lowest position. The Thyca-Qol questionnaire was the most commonly used tool, though most studies had limitations, including selection and recall biases. However, across geographically and culturally diverse populations, scar-related concerns consistently ranked lower in importance compared to other QoL factors.</p><p><strong>Conclusions: </strong>The impact of surgical scars on QoL in thyroid cancer survivors is low, with scar-related items ranking among the least significant issues. Remote access techniques designed primarily for cosmetic outcomes should demonstrate additional benefits to justify their use.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70155"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ropivacaine Versus Bupivacaine in Pediatric Tonsillectomy: A Systematic Review and Meta-Analysis.","authors":"Ebraheem Albazee, Khaled Alenezi, Abdulwahab Alkandari, Abdullah Al Sahli, Faisal Almulla, Khalaf A Alnowaishiri, Athari Alwael","doi":"10.1002/oto2.70166","DOIUrl":"10.1002/oto2.70166","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the analgesic efficacy and safety of local anesthetic infiltration in the tonsillar fossa using ropivacaine compared to bupivacaine in pediatric patients undergoing tonsillectomy.</p><p><strong>Data sources: </strong>CENTRAL, PubMed, Web of Science, Scopus, and Google Scholar.</p><p><strong>Review methods: </strong>Eligible randomized controlled trials (RCTs) were evaluated for risk of bias using Cochrane's Risk of Bias Tool (RoB-2). The primary outcome was postoperative pain within the first 24 hours following tonsillectomy. Secondary outcomes included the time to first analgesic requirement and complication rates (ie, bleeding, airway obstruction, local anesthetic toxicity, and nausea). Data were synthesized using the standardized mean difference (SMD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes, both reported with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Seven RCTs with a total of 375 patients were analyzed. Regarding posttonsillectomy pain scores, there was no significant difference between ropivacaine and bupivacaine at 1 hour (SMD = -0.01, 95% confidence interval [CI] [-0.36, 0.34]), 2 hours (SMD = 0.03, 95% CI [-0.45, 0.51]), 4 hours (SMD = -0.17, 95% CI [-0.39, 0.06]), 6-8 hours (SMD = 0.04, 95% CI [-0.38, 0.46]), and 12 hours (SMD = -0.23, 95% CI [-0.62, 0.15]). However, at 24 hours, ropivacaine demonstrated a superior effect compared to bupivacaine (SMD = -0.23, 95% CI [-0.43, -0.03]). There was no significant difference between ropivacaine and bupivacaine in terms of time to first analgesia and complication rates (<i>P</i> > .05).</p><p><strong>Conclusion: </strong>This meta-analysis demonstrated that ropivacaine and bupivacaine offer comparable clinical analgesic efficacy and safety profiles in pediatric patients undergoing tonsillectomy.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70166"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglossal Nerve Stimulator Lead Extrusion: Successful Management and Reimplantation.","authors":"Iman Adibi, Arman Saeedi, Alyssa N Calder, Ryan Nord","doi":"10.1002/oto2.70169","DOIUrl":"10.1002/oto2.70169","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70169"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of High-Resolution Esophageal Manometry in the Evaluation of Presumed Oropharyngeal Dysphagia.","authors":"David Ahmadian, Phil Tseng, Avin Aggarwal, Austin Lever, Kathleen Cazzato, Helena Yip","doi":"10.1002/oto2.70168","DOIUrl":"10.1002/oto2.70168","url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the utility of high-resolution esophageal manometry (HREM) in patients with symptoms of oropharyngeal dysphagia (OD) but unremarkable Modified Barium Swallow Studies (MBSS).</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary academic center.</p><p><strong>Methods: </strong>A retrospective review was conducted on patients with symptoms of oropharyngeal dysphagia from January 2021 to December 2024. Demographics, symptoms, and Charlson Comorbidity Index scores were recorded. Patients with unremarkable MBSS then underwent HREM. HREM data based on the Chicago Classification V 3.0 were analyzed, including mean residual upper esophageal sphincter (UES) pressure, median lower esophageal sphincter (LES) pressure, and ineffective swallow rates, using <i>T</i>-tests, and Chi-Squared tests.</p><p><strong>Results: </strong>Among 29 patients (mean age 53.2 years, 48.7% female), HREM findings showed mean residual UES pressure of -0.5 mmHg, median residual LES pressure of 13.9 mmHg, and 22.9% ineffective swallows. Esophageal pathologies (ineffective esophageal motility or esophagogastric junction outflow obstruction) were identified in 58.6% of cases. Symptom-specific differences in esophageal motility disorders were not statistically significant.</p><p><strong>Conclusion: </strong>HREM identified esophageal pathologies in 58.6% of patients with OD symptoms and normal MBSS, highlighting its value in the diagnostic workup of oropharyngeal dysphagia. The overlap of symptoms between oropharyngeal and esophageal motility disorders supports integrating HREM for comprehensive evaluation.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70168"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Clarity of Retractions and the Spread of Misinformation in Otolaryngology.","authors":"Andrew R Cunningham, Adam J Kimple, M Sean Peach","doi":"10.1002/oto2.70158","DOIUrl":"10.1002/oto2.70158","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clarity of retraction notices in otolaryngology journals and examine the relationship between retraction notice clarity and improper post-retraction citations.</p><p><strong>Study design: </strong>A retrospective analysis of retracted articles in otolaryngology journals from journal inception to August 1, 2024.</p><p><strong>Setting: </strong>Articles were selected from leading otolaryngology journals with citation data retrieved from major academic databases.</p><p><strong>Methods: </strong>Retracted articles were identified using the Retraction Watch Database. Citation patterns were analyzed through Google Scholar and Scopus. Retraction notices were evaluated for adherence to Committee on Publication Ethics (COPE) guidelines. The study included 80 retracted articles, with 1398 citations in Google Scholar and 714 in Scopus. Primary outcomes included the proportion of retraction notices meeting COPE guidelines and the rate of improper post-retraction citations.</p><p><strong>Results: </strong>Retraction notices adhered to COPE guidelines in 52.5% of cases (N = 42). Among 80 retracted articles, only 42.5% were labeled as retracted across all platforms. Alarmingly, 98.2% of citations that occurred after articles were retracted did not acknowledge their retracted status. Clearer retraction notices correlated with fewer improper citations. Proper labeling across all platforms led to a 52.89% reduction in citation rates, whereas any missing labels resulted in only a 28.72% reduction.</p><p><strong>Conclusion: </strong>Clarity in retraction notices significantly impacts improper citation rates. Standardized, prominently displayed retraction notices adhering to ethical guidelines can reduce misinformation. Strengthening retraction practices and improving database integration are recommended to enhance the effectiveness of retractions and maintain scientific integrity.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70158"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}