OTO Open最新文献

{"title":"Trends in Medicare Office-Based Procedures for Chronic Rhinitis and Nasal Obstruction.","authors":"Seth S Jeong, Mark Arnold","doi":"10.1002/oto2.70219","DOIUrl":"https://doi.org/10.1002/oto2.70219","url":null,"abstract":"<p><strong>Objective: </strong>To examine national trends in Medicare office-based procedures for chronic rhinitis and nasal obstruction, emphasizing minimally invasive interventions such as posterior nasal nerve (PNN) ablation and nasal valve repair with radiofrequency ablation.</p><p><strong>Study design: </strong>Retrospective longitudinal analysis of Medicare physician and provider utilization data from 2017 to 2023.</p><p><strong>Setting: </strong>Office-based procedural care across the United States.</p><p><strong>Methods: </strong>Current Procedural Terminology (CPT) codes 30117 (destruction of intranasal lesion), 30140 (inferior turbinate submucous resection), 31295 (maxillary balloon dilation), and 30802 (radiofrequency inferior turbinate reduction) were analyzed, focusing on office-based procedures. CPT 30117 served as a surrogate for PNN ablation and nasal valve repair using radiofrequency ablation. Annual service counts, beneficiaries, Medicare payments, total spending, provider-level adoption, geographic distribution, and early adopter patterns were analyzed. Linear regression evaluated trends over time (<i>P</i> < .05).</p><p><strong>Results: </strong>From 2017 to 2023, CPT 30117 services rose from 1009 to 11,409 (compound annual growth rate [CAGR] 49.8%), 30140 increased from 3218 to 5792 (CAGR 10.3%), 31295 slightly declined (10,3120 → 9180; CAGR -1.9%), and 30802 declined from 1353 to 863 (CAGR -7.2%). Spending grew sharply for 30117 ($0.41M → $5.08M; +1139%) and 31295 ($12.36M → $15.4M; +25%), modestly for 30140 ($0.89M → $1.05M; +18%), and declined for 30802 ($0.19M → $0.10M; -47%). Texas, Florida, and Arizona had concentrated utilization.</p><p><strong>Conclusion: </strong>In-office use of CPT 30117 has grown rapidly, outpacing other nasal procedures, reflecting the adoption of new PNN ablation and nasal airway remodeling devices. These trends underscore the need for ongoing evidence development, with further clarification anticipated following new device and procedure-specific coding.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70219"},"PeriodicalIF":1.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric Measurements Inform Complete Concentric Collapse Status in Patients With Obstructive Sleep Apnea.","authors":"Jordan S Weiner, Eugene G Chio, Raj C Dedhia, Colin T Huntley, Michael J Hutz, Phillip Huyett, Daniel J Lee, Philip LoSavio, Ilya Perepelitsyn, Ryan J Soose, David T Kent","doi":"10.1002/oto2.70245","DOIUrl":"https://doi.org/10.1002/oto2.70245","url":null,"abstract":"<p><strong>Objective: </strong>Hypoglossal nerve stimulation in the US requires drug-induced sleep endoscopy to exclude patients with complete concentric collapse. This is an expensive and time-consuming requirement. We hypothesized that supine pharyngeal width, and other demographic and polysomnographic variables would associate with complete concentric collapse.</p><p><strong>Study design: </strong>Prospective, multicenter cohort study.</p><p><strong>Setting: </strong>10 centers in the United States with experience selecting patients for and performing airway surgeries for sleep apnea including hypoglossal nerve stimulation implantation.</p><p><strong>Methods: </strong>600 patients meeting criteria for hypoglossal nerve stimulation underwent measurement of supine pharyngeal width and collection of demographic and polysomnographic data followed by drug-induced sleep endoscopy.</p><p><strong>Results: </strong>587 patients completed the study. Patients with complete concentric collapse had a higher body mass index (31.2 ± 3.2 vs 29.0 ± 3.4 kg/m², <i>P</i> < .001), larger neck circumference (45.5 ± 4.2 vs 40.6 ± 4.7 cm, <i>P</i> < .001), and lower supine pharyngeal width (19.4 ± 6.3 vs 21.8 ± 6.5 mm; <i>P</i> = .008) than patients without complete concentric collapse.</p><p><strong>Conclusion: </strong>Body mass index, neck circumference, and supine pharyngeal width all associate with complete concentric collapse and could potentially be used to determine hypoglossal nerve stimulation candidacy instead of drug-induced sleep endoscopy for most patients thereby reducing both time and cost. (ClinicalTrials.gov NCT05428839: https://clinicaltrials.gov/study/NCT05428839?term=Inspire%20Medical%20systems%20predictor&rank=1).</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70245"},"PeriodicalIF":1.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Social Vulnerability Index and Severity of Pretreatment Swallowing Dysfunction for Oropharyngeal Cancer Patients.","authors":"Prerita Pandya, Shravan Asthana, Hannah Soltani, Alex Clain, Kirsten B Burdett, Laila A Gharzai, Urjeet Patel, Sandeep Samant, Andrew P Stein, Bonnie Martin-Harris, Katelyn O Stepan","doi":"10.1002/oto2.70242","DOIUrl":"https://doi.org/10.1002/oto2.70242","url":null,"abstract":"<p><strong>Objective: </strong>Given growing recognition that social determinants of health influence cancer outcomes and functional status, we sought to examine associations between social vulnerability, measured by CDC's Social Vulnerability Index (SVI), and pretreatment swallowing function, quantified by Modified Barium Swallow Impairment Profiles (MBSImP), in patients with oropharyngeal squamous cell carcinoma (OPSCC).</p><p><strong>Study design and setting: </strong>Retrospective analysis of patients at Northwestern University with pretreatment MBSImP studies.</p><p><strong>Methods: </strong>MBSImP oral total (OT) and pharyngeal total (PT) scores were calculated, and SVI assigned to patient residential address at diagnosis. Associations between overall SVI, SVI subcomponents, clinical variables, and OT and PT scores were assessed using univariable and multivariable linear regression.</p><p><strong>Results: </strong>149 OPSCC patients with median age 63 years; 83.9% were male, 89.9% White, and 91.9% p16+. On univariable analysis, SVI was significantly associated with higher (worse) OT (<i>β</i> = 3.3; 95% CI: 1.8, 4.8; <i>P</i> < .001) and PT scores (<i>β</i> = 3.6; 95% CI: 0.75, 6.4; <i>P</i> = .013). After multivariable adjustment, SVI remained independently associated with increased OT scores (<i>β</i> = 2.3; 95% CI: 0.36, 4.2; <i>P</i> = .020); PT impairment was independently predicted by tumor subsite (tonsil vs. base of tongue: <i>β</i> = -1.8; 95% CI: -3.4, -0.28; <i>P</i> = .021). All four SVI domains were significantly linked to OT in univariable models.</p><p><strong>Conclusion: </strong>Social vulnerability independently predicts oral-phase swallowing impairment in OPSCC patients, while tumor subsite primarily determines pharyngeal swallowing impairment. These findings highlight the need to consider social determinants in pretreatment assessment, as well as further research to clarify how social determinants impact swallowing outcomes to identify effective, targeted interventions for high-risk groups.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70242"},"PeriodicalIF":1.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications Associated With Polycaprolactone (PCL) Use in Septorhinoplasty: A Systematic Review and Meta-Analysis.","authors":"Panutas Piyananthasomdee, Minh P Hoang, Kachorn Seresirikachorn, Witsanu Jullamusi, Prapitphan Charoenlux","doi":"10.1002/oto2.70248","DOIUrl":"https://doi.org/10.1002/oto2.70248","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the complications associated with polycaprolactone (PCL) use in septorhinoplasty.</p><p><strong>Data sources: </strong>OVID EMBASE, OVID MEDLINE, SCOPUS, and PubMed.</p><p><strong>Review methods: </strong>Studies reporting complications related to PCL in septorhinoplasty were included. Primary outcomes encompassed complications including tip deformity/warping, stiffness, deviation, infection, protrusion/extrusion, skin complications, epistaxis, and revision/reoperation. Subgroup analyses were conducted based on the type of operation, approach, surgery, graft, and material used.</p><p><strong>Results: </strong>A total of 13 studies, including 1194 patients, were analyzed. The pooled mean proportion of complications was relatively low, ranging from 0% to 0.72% (deviation 0% [95% CI -0.00 to 0.01], skin complications 0% [95% CI -0.00 to 0.00], infection 0.01% [95% CI 0.00-0.01], protrusion/extrusion 0.01% [95% CI 0.00-0.01], tip decrease/warping 0.02% [95% CI -0.00 to 0.04], revision/reoperation 0.03% [95% CI 0.02-0.03], epistaxis 0.07% [95% CI -0.06 to 0.21], and stiffness 0.72% [95% CI 0.59-0.85]). Subgroup analyses showed no statistically significant differences in complication based on operation type or graft type for tip decrease/warping (<i>P</i> = .70, <i>P</i> = .54), deviation (<i>P</i> = .16, <i>P</i> = .37), infection (<i>P</i> = .26, <i>P</i> = .68), protrusion/extrusion (<i>P</i> = .25, <i>P</i> = .73), skin complications (<i>P</i> = .25 for graft type), and revision/reoperation (<i>P</i> = .97, <i>P</i> = .99). Subgroup analysis by type of surgical approach (open, endonasal), type of procedure (primary, revision), and type of material (PCL, PCL combined with cartilage) could not be performed due to limitations in the original data.</p><p><strong>Conclusion: </strong>PCL appears to demonstrate acceptable short- to mid-term safety in septorhinoplasty. However, long-term and comparative data are needed to better define its role.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 ","pages":"e70248"},"PeriodicalIF":1.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Alpha1-Antitrypsin Demonstrated Protective Effects Against Auditory Impairment in Murine Model of Noise-Induced Hearing Loss.","authors":"Benyamin M Kaminer, Sabri El-Saied, Ismael Abu Freh, Amit Amar, Oren Ziv, Daniel M Kaplan, Eli C Lewis","doi":"10.1002/oto2.70238","DOIUrl":"https://doi.org/10.1002/oto2.70238","url":null,"abstract":"<p><strong>Objective: </strong>The pathophysiology of noise-induced hearing loss (NIHL) encompasses excessive inflammation, tissue damage, production of reactive oxygen species, and apoptotic processes, culminating in irreversible damage to hair cells. Currently, no clinical interventions are available to mitigate this condition. Alpha1-antitrypsin (AAT) is a circulating molecule with tissue-protective properties that increases during inflammatory states and facilitates the resolution of inflammation. Transgenic mice expressing elevated levels of human AAT have demonstrated enhanced tissue repair in various in vivo models, including restoration of vestibular function following inner ear trauma. We hypothesized that the transgenic overexpression of human AAT would offer protection against permanent threshold shifts following noise exposure in mice, as compared to wild-type controls.</p><p><strong>Study design: </strong>A murine model of NIHL.</p><p><strong>Setting: </strong>Laboratory study.</p><p><strong>Methods: </strong>Wild-type C57BL/6 and transgenic mice expressing human AAT (n = 5 per group) were exposed to broadband noise at a sound pressure level of 100 dB SPL for 2 hours. Auditory brainstem responses were measured.</p><p><strong>Results: </strong>hAAT mice showed a greater threshold shift at 24 hours but near-complete recovery by Day 7, unlike WT mice that developed a permanent threshold shift.</p><p><strong>Conclusions: </strong>hAAT promotes recovery after acoustic trauma, suggesting a potential therapeutic role in NIHL. WT and hAAT groups had similar baseline thresholds. At 24 hours postnoise exposure, hAAT mice exhibited a greater threshold shift than WT mice. By Day 7, hAAT thresholds had nearly recovered to baseline, whereas WT thresholds remained elevated, consistent with permanent hearing loss. Further research is required to elucidate the protective effects of AAT on the inner ear.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70238"},"PeriodicalIF":1.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone Adapters for Endoscopy: Current Use Among US Otolaryngology Residency Programs.","authors":"Soraya Abdul Hadi Martínez, Clariliz Munet Colón, Javier Antonio Vilá Ortiz, Mario González Carbonell, Edgar Del Toro Diez, Jeamarie Pascual Marrero","doi":"10.1002/oto2.70205","DOIUrl":"https://doi.org/10.1002/oto2.70205","url":null,"abstract":"<p><strong>Objective: </strong>Smartphone adapters for flexible nasopharyngolaryngoscopy provide an accessible means for video documentation, enhancing both resident education and patient care. This study evaluates the current utilization of smartphone adapters for endoscopy among Otolaryngology Residency Programs in the United States.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>ACGME-accredited Otolaryngology Residency Programs.</p><p><strong>Methods: </strong>A 14-question survey was distributed to ACGME-accredited Otolaryngology Residency Programs during 2023. Responses regarding smartphone adapter use, training-level differences, barriers, and perceived benefits were analyzed using descriptive statistics.</p><p><strong>Results: </strong>A total of 115 residents from 27 states and Puerto Rico responded, with 62% being upper-level residents (PGY 3-5). Only 44% of respondents reported using smartphone adapters for endoscopy. The most cited barrier was lack of awareness (53%), followed by unavailability in residency programs (19%) and cost (11%). Among users, the primary reasons for adoption included video documentation for senior discussion (100%), patient education (63%), and airway handoffs (57%). The emergency room was the most common setting (100%), where 90% of residents lacked access to video endoscopic towers. The principal procedures performed with adapters were flexible laryngoscopy (100%) and nasal endoscopy (82%). Most residents reported using the Endoscope-i (41%) or Storz Smart Endoscope (23%), while a minority (4%) used 3-D printed models. Nearly all users (98%) considered smartphone adapters to be valuable for communication, case discussion, and clinical decision-making.</p><p><strong>Conclusion: </strong>Smartphone endoscopy adapters remain underutilized in Otolaryngology residency training. Given their educational and clinical benefits, formal integration into residency training programs may enhance patient care, resident learning, and interspecialty communication.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70205"},"PeriodicalIF":1.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otolaryngology Provider Distribution Disparities in Pennsylvania.","authors":"Edra K Ha, Natasha Mayer, Eugene Kim, Katie M Carlson, Angela L Mazul","doi":"10.1002/oto2.70236","DOIUrl":"https://doi.org/10.1002/oto2.70236","url":null,"abstract":"<p><strong>Objective: </strong>To assess the distribution of otolaryngology providers within Pennsylvania.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>State of Pennsylvania.</p><p><strong>Methods: </strong>Otolaryngologists in Pennsylvania were analyzed based on their associated state Area Deprivation Indexes (ADIs) and Rural-Urban Commuting (RUCA) Codes, as determined by census tract data.</p><p><strong>Results: </strong>Of 563 otolaryngology providers identified in Pennsylvania, 477 (83.7%) had office addresses with available RUCA codes and 446 (79.2%) with associated ADI measures. Providers were predominantly located in urban settings, with 466 (93.5%) reporting a primary clinic address in a metropolitan area (RUCA 1-3) and 25 (5.2%) in a micropolitan area (RUCA 3-6). Notably, only 4 (0.8%) providers had primary clinic addresses in small towns (RUCA 7-9) and 2 (0.4%) in rural areas (RUCA 10). Similarly, 171 (38.3%) of providers were situated in areas with an ADI in the top 2 deciles (1-2), while only 56 (12.6%) had clinic addresses in deciles 9-10 (most deprived areas).</p><p><strong>Conclusion: </strong>Pennsylvania faces disparities in access to otolaryngology providers based on socioeconomic and urban-rural workforce distribution.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70236"},"PeriodicalIF":1.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Complete Spontaneous Hearing Recovery in a Pediatric Chemotherapy Patient-A Case Report.","authors":"Mihai A Bentan, Aaron Tucker, Meghan Nemeth, Daniel H Coelho","doi":"10.1002/oto2.70243","DOIUrl":"https://doi.org/10.1002/oto2.70243","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70243"},"PeriodicalIF":1.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Thyroid Gland Volume and Postoperative Hypothyroidism Following Hemithyroidectomy.","authors":"Mayas Arraf, Alaa Safia, Adi Sharabi-Nov, Moanes Awad, Yaniv Avraham, Ohad Ronen, Shlomo Merchavy","doi":"10.1002/oto2.70239","DOIUrl":"https://doi.org/10.1002/oto2.70239","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the proportion of resected thyroid tissue or the residual lobe volume predicts postoperative hypothyroidism following hemithyroidectomy.</p><p><strong>Study design: </strong>Multicenter retrospective cohort study.</p><p><strong>Setting: </strong>Ziv Medical Center and Galilee Medical Center, Israel.</p><p><strong>Methods: </strong>The study included 134 adult patients who underwent hemithyroidectomy between 2017 and 2024. Patients with preexisting hypothyroidism or malignant histopathology were excluded. Preoperative thyroid gland volumes were measured by computed tomography (CT) and correlated with serum thyroid hormone profiles (T3, T4, and TSH) obtained preoperatively, and at 1 and 6 months postoperatively. Associations between thyroid volume parameters and postoperative hypothyroidism were analyzed statistically.</p><p><strong>Results: </strong>Postoperative hypothyroidism developed in 29.1% of patients, within the first postoperative month. Affected patients exhibited significantly higher baseline TSH levels than euthyroid counterparts (3.0 vs 1.4 μIU/mL, <i>P</i> < .001). No significant correlation was found between postoperative thyroid function and total gland volume, resected lobe volume, or residual-to-total volume ratio. At 6 months, only 12% of patients remained hypothyroid, suggesting partial recovery of thyroid function in the remaining lobe.</p><p><strong>Conclusion: </strong>Neither the extent of resection nor the residual thyroid volume predicted postoperative hypothyroidism. These findings imply that factors beyond gland size-such as preoperative functional reserve or intrinsic thyroid health-may play a more decisive role in maintaining postoperative endocrine stability. Identifying these predictors could enhance patient selection, risk stratification, and postoperative follow-up.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70239"},"PeriodicalIF":1.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Recurrence Risk of Human Papillomavirus-Related Pharyngeal Papilloma: A Retrospective Study.","authors":"Ryohei Asai, Hiroumi Matsuzaki, Kiyoshi Makiyama, Takeshi Oshima","doi":"10.1002/oto2.70244","DOIUrl":"https://doi.org/10.1002/oto2.70244","url":null,"abstract":"<p><strong>Objective: </strong>The association between pharyngeal papilloma and human papillomavirus (HPV) remains unclear. Although previous studies have suggested that HPV involvement is unlikely, we encountered HPV-positive cases, particularly in patients with multiple lesions, malignancy, or recurrence. This study aimed to clarify the relationship between HPV infection and clinicopathological features of pharyngeal papilloma, including recurrence and malignant transformation.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Setting: </strong>Department of Otolaryngology-Head and Neck Surgery, Nihon University Hospital, a single tertiary referral center in Tokyo, Japan.</p><p><strong>Methods: </strong>We retrospectively reviewed HPV-DNA test results and clinical data from 69 patients with pharyngeal papilloma who underwent surgical resection between August 2006 and September 2018. Koilocytosis was histologically assessed, and associations between HPV status and recurrence, multiplicity, and malignant transformation were analyzed.</p><p><strong>Results: </strong>Among 69 patients, 5 (7.2%) were HPV-positive, including four (5.8%) low-risk types (6, 11) and 1 (1.4%) high-risk type (16). Koilocytosis was observed in 88% of cases. HPV-positive cases had higher recurrence, multiplicity, and malignant transformation rates compared with HPV-negative cases.</p><p><strong>Conclusion: </strong>HPV DNA was detected in 7.2% of cases. HPV-positive papillomas showed higher recurrence and malignanct transformation rates. Detection of HPV DNA may serve as a prognostic factor, and koilocytosis in HPV-negative cases may reflect prior transient HPV infection.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 2","pages":"e70244"},"PeriodicalIF":1.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}