OTO Open最新文献

{"title":"Three-Dimensional Printing Simulator for Endoscopic Adenoidectomy Training.","authors":"Ana Luiza De Bortoli De Paula, Raimar Weber, Aldo Cassol Stamm, Gabriela Batista Holanda, Carolina Pontes Lima","doi":"10.1002/oto2.70043","DOIUrl":"10.1002/oto2.70043","url":null,"abstract":"<p><p>This article presents an innovative approach to adenoidectomy training through the development of a 3-dimensional (3D) printing model, termed e-A.L.Ex (endoscopic-adenoidectomy learning experience). Adenoidectomy, a common procedure in otolaryngology, has evolved with the integration of endoscopic techniques, necessitating precise training methodologies. The model, created from computed tomography scans and utilizing 3D printing technology, accurately replicates anatomical structures crucial for adenoidectomy. Surgical simulation with bovine thymus mimics adenoid tissue, providing a realistic training experience. Collaboration with a 3D printing company ensured the model's development, emphasizing ethical considerations, and obtaining institutional approval. The discussion highlights the model's significance in enhancing surgical education and addressing the learning curve associated with endoscopic procedures. Overall, the e-A.L.Ex model represents a pivotal tool in advancing endoscopic adenoidectomy training, with implications for improving surgical outcomes.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70043"},"PeriodicalIF":1.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Health Disparities in Chronic Rhinosinusitis in the United States.","authors":"Russell A Whitehead, Abdel R Metwally, Evan A Patel, Thomas Cyberski, Robin Powszok, Peter Filip, Peter Papagiannopoulos, Bobby A Tajudeen, Pete S Batra","doi":"10.1002/oto2.70163","DOIUrl":"10.1002/oto2.70163","url":null,"abstract":"<p><strong>Objective: </strong>Literature describing disparities in chronic rhinosinusitis (CRS) often analyzes race, gender, or socioeconomic status (SES) in isolation. Analyses encompassing a comprehensive range of disparities remain lacking. We conducted a systematic review to provide a detailed characterization of the CRS disparity landscape.</p><p><strong>Data sources: </strong>A systematic review was conducted in Covidence adhering to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A search of PubMed/MEDLINE, CINAHL, Scopus, etc. was performed for literature published through September 2024.</p><p><strong>Review methods: </strong>A total of 690 publications were identified and screened by two authors independently. In total, 26 ultimately met the inclusion criteria. Studies were classified by pertaining health disparity (race, gender, SES, age, and geographic region) and reported outcomes (incidence, severity, and treatment choice).</p><p><strong>Results: </strong>In total, 26 studies on CRS disparities were published from 2012 to 2024. 16 focused on SES, describing that lower SES was associated with reduced treatment adherence, resulting in poorer endoscopic findings and quality of life. 14 studies examined racial/ethnic disparities. Hispanic patients were more symptomatic than non-Hispanic patients, whereas black patients had fewer health visits, leading to worse outcomes. Other studies discussed the impact of gender, age, and/or geographic region (n = 9, 4, 4, respectively). Findings included higher symptom burden among female patients and higher CRS incidence in regions of air pollution. Only three studies proposed solutions to disparities.</p><p><strong>Conclusion: </strong>Most literature on CRS disparities describes the influence of SES and race on disease presentation and progression. Other disparities related to gender, age, and geographic region were identified. Further research should uncover root causes and propose detailed solutions to advance equitable care in CRS.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70163"},"PeriodicalIF":1.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-the-Counter Medications for Sinus Headache: A Cross-Sectional Survey Study.","authors":"Nathan Gabriel Sattah, Hui-Jie Lee, Theresa Coles, Frederick Godley, Bradley J Goldstein, Ralph Abi Hachem, David W Jang","doi":"10.1002/oto2.70161","DOIUrl":"10.1002/oto2.70161","url":null,"abstract":"<p><strong>Objective: </strong>Sinus headache is a common complaint that can be due to chronic rhinosinusitis (CRS) or non-rhinogenic facial pain/pressure (NRFP). The purpose of this study is to characterize over-the-counter (OTC) medications used for sinus headache.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Tertiary care academic center.</p><p><strong>Methods: </strong>Patients presenting with midfacial pain or pressure to a rhinology clinic were surveyed on how often they utilized common OTC medications, with choices ranging from \"always\" to \"never.\" Patients were categorized into CRS or NRFP groups based on endoscopy and imaging.</p><p><strong>Results: </strong>The study included 251 patients, with 69.3% female and a mean (standard deviation) age of 49.9 (15.7) years. Patients with CRS (n = 114) reported symptom relief \"sometimes\" to \"always\" when using pain relievers (38.6%), intranasal steroids (37.7%), and oral antihistamines (36%). Patients with NRFP (n = 137) responded \"sometimes\" to \"always\" with the use of intranasal steroids (49.6%), decongestants (48.9%), and pain relievers (45.3%). A greater proportion of NRFP patients responded \"sometimes\" to \"always\" for decongestants to relieve symptoms compared to CRS patients (<i>P</i> = .011). There was no significant difference in other OTC medications between groups.</p><p><strong>Conclusion: </strong>Patients with midfacial pain or pressure reported using a variety of OTC medications for symptomatic relief. Decongestants were more frequently associated with symptom improvement in patients with NRFP. This finding indicates that symptomatic relief with decongestants may suggest a diagnosis of NRFP.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70161"},"PeriodicalIF":1.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient Nebulized Ciprofloxacin-Dexamethasone After Endoscopic Airway Surgery in Adults: Tolerability, Safety, and Adherence.","authors":"Cyrus W Abrahamson, Abbey L Landini, Jonathan P Kuriakose, Jasmine Stewart, James A Burns, Andrew P Stein","doi":"10.1002/oto2.70153","DOIUrl":"10.1002/oto2.70153","url":null,"abstract":"<p><strong>Objective: </strong>Nebulized ciprofloxacin-dexamethasone represents an adjuvant medication utilized following airway surgery. However, minimal objective information exists on this treatment, especially over more extended periods. This study measured the safety, tolerability, and adherence to nebulized ciprofloxacin-dexamethasone utilized in the outpatient setting after endoscopic airway surgery for adult patients.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Single-institution academic center.</p><p><strong>Methods: </strong>All patients with laryngotracheal stenosis managed by a single surgeon from 2021 to 2024 who underwent endoscopic airway surgery were included. Patient demographics, stenosis etiology, comorbidities, and ciprofloxacin-dexamethasone prescriptions were documented. Ciprofloxacin-dexamethasone dose, duration of treatment, adherence, tolerability, and side effects were collected. Potential side effects evaluated included allergic reactions, postoperative infections and pneumonia, and Cushingoid symptoms.</p><p><strong>Results: </strong>Sixty-nine adult patients underwent endoscopic airway surgery to treat laryngotracheal stenosis, and fifty-nine were prescribed nebulized ciprofloxacin-dexamethasone postoperatively. Fifty-two patients (88.1%) filled their prescription and utilized this treatment regimen. Importantly, over 90% (47/52) of this cohort completed the prescribed four-week regimen. Four patients (7.7%) experienced temporary side effects, which dissipated after discontinuation: two altered taste/smell, one nausea/chills, and one blurry vision. No significant complications were reported.</p><p><strong>Conclusion: </strong>Nebulized ciprofloxacin-dexamethasone is a safe and tolerable treatment for adult patients after endoscopic airway surgery. The majority of patients were able to obtain, adhere to, and successfully utilize this medication in the outpatient setting. This study represents an important step in understanding the tolerability of this adjuvant treatment regimen.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70153"},"PeriodicalIF":1.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sphenoid Mucocele Complicated With Partial Medial Pontine Syndrome.","authors":"Yu-Han Wang, Ya-Fang Chen, Ting-Hua Yang, Chih-Feng Lin","doi":"10.1002/oto2.70159","DOIUrl":"10.1002/oto2.70159","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70159"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Esophageal Dysmotility Diagnostic Studies in Head and Neck Cancer Survivors With Dysphagia.","authors":"Akhil Katragadda, Molly O Meeker, Mohammad Bilal Alsavaf, Jack Birkenbeuel, Zachary Wykoff, Songzhu Zhao, Apoorva Ramaswamy","doi":"10.1002/oto2.70154","DOIUrl":"10.1002/oto2.70154","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to characterize the relationship of esophageal dysmotility on modified barium swallow (MBS) and esophagram studies with high-resolution manometry (HRM), the gold standard of esophageal dysmotility diagnosis, in head and neck cancer (HNC) survivors with dysphagia.</p><p><strong>Study design: </strong>Retrospective diagnostic accuracy study.</p><p><strong>Setting: </strong>Specialty dysphagia clinic at a tertiary care center.</p><p><strong>Methods: </strong>A retrospective analysis of 30 patients treated for dysphagia between 2020 and 2023 was conducted. Inclusion criteria required HNC survivors aged 18 years or older who were diagnosed with dysphagia, treated in a HNC dysphagia clinic, and completed at least one HRM study. Data were collected on patient demographics, cancer history, MBS, esophagram, and HRM studies. MBS and esophagram results were reviewed for evidence of esophageal dysmotility. HRM studies were assessed with the Chicago Classification Version 4.0. Data were summarized and analyzed using <i>t</i> test for continuous variables and a chi-square test for categorical variables. McNemar's test and diagnostic odds ratios were calculated to compare diagnostic test results.</p><p><strong>Results: </strong>Of the 30 patients reviewed, 20 (67%) showed dysmotility on HRM, 15 (50.0%) completed MBS only, 2 (6.7%) completed esophagram only, and 13 (43.3%) completed both MBS and esophagram. MBS and esophagram accurately identified dysmotility in 66.7% and 76.9% of patients with confirmed dysmotility on HRM, respectively.</p><p><strong>Conclusion: </strong>Esophageal dysmotility is an understudied comorbidity of dysphagia in the HNC survivor population. Our study suggests that MBS and esophagram have limited predictive value in the assessment of dysmotility in HNC survivors with dysphagia. Thus, future studies should aim to better understand the relationship between other aspects of post-HNC dysphagia and esophageal dysmotility.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70154"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngeal Clear Cell Carcinoma: A Systematic Review.","authors":"Gabriele Noreikaite, Savannah Nicks, Daniel Lofgren, Kerolos Shenouda, Olga Santiago Rivera","doi":"10.1002/oto2.70157","DOIUrl":"10.1002/oto2.70157","url":null,"abstract":"<p><strong>Objective: </strong>Laryngeal clear cell carcinoma (LCCC) is an exceedingly rare tumor. Current literature on LCCC is limited to case reports with little comprehensive data available. This systematic review aims to analyze existing literature to better characterize LCCC and to identify trends in presentation, treatment, and survival.</p><p><strong>Data sources: </strong>A literature search of PubMed, MedLine, and Embase was conducted.</p><p><strong>Review methods: </strong>A systematic review of LCCC cases from 1976 to 2024 was performed. Data extraction followed PRISMA guidelines. Included studies were those describing adult or pediatric patients pathologically diagnosed with LCCC. Excluded studies were those describing nonclear cell pathology, nonlaryngeal location, or nonprimary clear cell carcinoma.</p><p><strong>Results: </strong>In total, 7 studies (n = 9 patients) were included in the analysis. Males (77.7%) were more commonly affected, with an average patient age of 56.5 years. The supraglottis was the most frequently involved subsite (66.6%). Most patients presented with advanced locoregional disease. Surgery alone was the most common treatment (66.6%), followed by chemoradiation (22.2%) and surgery with adjuvant chemoradiation (11.1%). Disease recurrence occurred in 55.5% of cases. Four patients (44.4%) died due to the disease, with an average survival of 9.3 months.</p><p><strong>Conclusion: </strong>LCCC is a rare tumor often presenting as a supraglottic mass with cervical metastasis. Patients underwent various treatments with surgery, chemoradiation, or a combination of both. Reported survival was generally poor, emphasizing the aggressive nature of this disease.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70157"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Mild Traumatic Brain Injury on the Subjective Perception of Hearing and Balance.","authors":"Alyssa M Civantos, Kennedy Johnson, Sultan Al Azzawi, Phiroz E Tarapore, Steven W Cheung, Jennifer H Sabes, Jolie L Chang, Megan L Durr","doi":"10.1002/oto2.70152","DOIUrl":"10.1002/oto2.70152","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic brain injury affects 1.5 million people per year in the United States, with the majority classified as mild (mTBI). While many immediate symptoms are limited to the short-term, some patients experience long-term daily impairments in function and quality of life. The objective of this study was to assess the relationship between mTBI post-concussive symptoms and hearing, tinnitus, and dizziness symptoms.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Level I public trauma center.</p><p><strong>Methods: </strong>Adult patients presenting with mTBI ≥6 months prior to study enrollment were asked to complete the Neurobehavioral Symptom Inventory (NSI), Revised Hearing Handicap Inventory (RHHI), Tinnitus Functional Index (TFI), and Dizziness Handicap Inventory (DHI) survey instruments. The NSI is a validated, self-reported measure of post-concussive symptoms. Linear regression analyses were performed.</p><p><strong>Results: </strong>A total of 38 subjects were recruited, with mean age of 52 (range 24-78), 74% male, 61% self-identifying as White, and 87% self-identifying as Non-Hispanic/Latinx. Median time since injury was 32.5 months (IQR 30-35). Mean NSI score was 22.32 (range 0-70), mean RHHI was 16.05 (0-68), mean TFI was 16.00 (0-85.2), and mean DHI was 18.86 (0-100). On linear regression, NSI score was positively correlated with RHHI, TFI, and DHI scores (<i>P</i> < .01).</p><p><strong>Conclusion: </strong>The postconcussive symptoms of mTBI are associated with impairments in hearing, tinnitus, and dizziness. Based on this work, structural causal models may be developed to dissect associations to inform management and treatment of mTBI patients with audiovestibular symptoms.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70152"},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic and Cost Analysis of Off-Label Nebulized Ciprofloxacin-Dexamethasone Use Following Airway Surgery.","authors":"Abbey L Landini, Cyrus W Abrahamson, Jonathan P Kuriakose, Jasmine Stewart, James A Burns, Andrew P Stein","doi":"10.1002/oto2.70156","DOIUrl":"10.1002/oto2.70156","url":null,"abstract":"<p><strong>Objective: </strong>Nebulized ciprofloxacin-dexamethasone (CPD) is an adjuvant, off-label treatment used to optimize healing after airway surgery, but there is limited data regarding its accessibility. This study examined socioeconomic factors influencing CPD utilization and assessed its cost.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Single institution tertiary care center.</p><p><strong>Methods: </strong>All patients prescribed nebulized CPD after endoscopic airway surgery from 2021 to 24 by a single surgeon were analyzed for associations between CPD access and socioeconomic factors including insurance type and Area Deprivation Index (ADI). The typical regimen was 2 mL CPD ophthalmic solution nebulized twice daily for 4 weeks. A model to estimate CPD cost combined retail pricing from GoodRx with cost-sharing calculations from Medicare plans including Aetna, Blue Cross Blue Shield (BCBS), and Cigna, incorporating co-pays, coinsurance, and deductibles.</p><p><strong>Results: </strong>Out of 59 patients prescribed CPD postoperatively, 52 (88.1%) filled their prescription. Patients with Medicaid and Medicare were less likely to access CPD than those with commercial insurance (<i>P</i> = .037). There was no association between ADI and CPD utilization (<i>P</i> = .514). CPD otic and ophthalmic solutions cost $420 and $255, respectively, utilizing GoodRx without insurance. The estimated price of CPD otic solution for patients with Medicare Advantage PPO plans was $340 (Aetna), $1362 (BCBS), and $47 (Cigna), whereas the ophthalmic solution cost $53, $51, and $40, respectively.</p><p><strong>Conclusion: </strong>Nebulized CPD was utilized by most patients regardless of ADI, but less accessible for those with Medicaid and Medicare. Prescribing the ophthalmic formulation instead of otic may significantly reduce cost and promote more equitable care postoperatively.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70156"},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Salivary Gland Biopsy in Pediatric Eosinophilic Granuolmatosis with Polyangiitis.","authors":"Keiko Fox, Nicole Wershoven, Soham Roy, Jeremy D Prager","doi":"10.1002/oto2.70149","DOIUrl":"10.1002/oto2.70149","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 3","pages":"e70149"},"PeriodicalIF":1.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}