OTO Open最新文献

{"title":"Computed Tomography-Measured Minimum Fascia-Tumor Distance for Parotid Tumor Location and Facial Palsy Prediction.","authors":"Yi-Chan Lee, Li-Yu Lee, Chi-Yin Lee, Ti-Yung Tseng, Yao-Te Tsai, Chih-Chen Chang, Kai-Ping Chang","doi":"10.1002/oto2.70302","DOIUrl":"10.1002/oto2.70302","url":null,"abstract":"<p><strong>Objective: </strong>To assess the diagnostic performance of CT-measured minimum fascia-tumor distance (MFTD) for predicting parotid tumor location and its association with postoperative facial nerve function.</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Setting: </strong>Referral hospital.</p><p><strong>Methods: </strong>This retrospective cohort study included 323 patients with benign parotid tumors treated at referral centers. CT-measured MFTD values were compared between superficial and deep lobe tumors. Diagnostic accuracy for identifying deep lobe tumors was evaluated using a receiver operating characteristic (ROC) curve. Univariable and multivariable logistic regression analyses were performed to identify predictive factors for tumor location and postoperative facial palsy.</p><p><strong>Results: </strong>MFTD significantly differed between superficial and deep lobe tumors (1.59 ± 2.14 mm vs. 3.90 ± 3.40 mm, <i>p</i> < .001). ROC analysis yielded an area under the curve of 0.70 (95% confidence interval [CI], 0.60-0.79; <i>p</i> < .001), with 3.0 mm identified as the optimal threshold. Independent predictors of deep lobe tumors included MFTD (odds ratio [OR], 1.34; 95% CI, 1.19-1.49; <i>p</i> < .001) and maximal tumor diameter (OR, 1.03; 95% CI, 1.00-1.06; <i>p</i> = .043). Predictors of postoperative temporary facial palsy were MFTD (OR, 1.26; 95% CI, 1.11-1.42; <i>p</i> < .001), female sex (OR, 3.17; 95% CI, 1.49-6.73; <i>p</i> = .003), and anterior tumor location (OR, 2.69; 95% CI, 1.21-6.00; <i>p</i> = .016).</p><p><strong>Conclusion: </strong>CT-based MFTD provides reliable diagnostic performance for distinguishing deep lobe parotid tumors. Beyond tumor localization, MFTD also predicts the risk of postoperative temporary facial palsy. Incorporating MFTD into preoperative planning and patient counseling may enhance surgical decision-making and outcomes.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70302"},"PeriodicalIF":1.6,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Neotongue Atrophy and Postoperative Outcomes in Patients Undergoing Glossectomy With Free Flap Tongue Reconstruction.","authors":"Audrey Abend, Sophia Salingaros, Adrienne Biskaduros, Matthew Spano, Matthew Wright, Sara Strauss, Jason A Spector, David I Kutler","doi":"10.1002/oto2.70305","DOIUrl":"https://doi.org/10.1002/oto2.70305","url":null,"abstract":"<p><strong>Objective: </strong>Following glossectomy, tongue reconstruction via autologous free flap can reapproximate native form and function, significantly improving postoperative quality of life. Various studies have examined functional outcomes between the commonly employed radial forearm free flap (RFFF) and the anterolateral thigh free flap (ALTFF); however, changes in neotongue volumetric bulk are less clearly understood.</p><p><strong>Study design: </strong>We aimed to assess postoperative outcomes and volume changes in patients undergoing glossectomy.</p><p><strong>Setting: </strong>This is a retrospective chart review of patients who underwent glossectomy with reconstruction at a single academic center.</p><p><strong>Methods: </strong>Patients who underwent hemiglossectomy with RFFF or ALTFF reconstruction were retrospectively identified. Patient demographics, past medical history, and treatment course were collected. Perioperative imaging was utilized to measure native tongue, tumor, and postoperative neotongue volumes.</p><p><strong>Results: </strong>Of 35 patients identified, ALTFF patients presented with greater tumor stage and depth of invasion than RFFF patients. Volumetric analysis of 17 patients revealed a mean tongue size decrease of 31.68 cm³ (SD, 42.02). Correlational analyses revealed a significant negative relationship of tongue volume over time (Spearman coefficient = -0.52, <i>P</i> = .04). Length of time was significant independent of flap type or mass volume (<i>F</i> = 4.85, <i>P</i> = .046). No significant relationship was found between flap type, tumor size, and change in total tongue size. ALTFF patients trended towards a greater rate of percutaneous endoscopic gastrostomy (PEG) tube dependence than RFFF patients at 1 month, but by 3 months all patients tolerated oral intake; however, ALTFF patients demonstrated a smaller absolute reduction in body mass index (BMI) compared to RFFF patients.</p><p><strong>Conclusion: </strong>Postoperative neotongue volume decreased in both the ALTFF and RFFF cohorts over time but was not impacted by flap type or tumor burden. Further research is warranted to understand the impact of flap design on neotongue atrophy.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70305"},"PeriodicalIF":1.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial-Ethnic Differences of Community Vulnerability Impact on Pediatric Thyroid Cancer Diagnosis and Surveillance.","authors":"David Fei-Zhang, Meredith Osmulski, Christopher Puchi, Abhinav Talwar, Jorge Gutierrez, John Maddalozzo, Jill D'Souza, Anthony Sheyn, Daniel Chelius, Jeffrey Rastatter","doi":"10.1002/oto2.70298","DOIUrl":"10.1002/oto2.70298","url":null,"abstract":"<p><strong>Objective: </strong>To assess racial-ethnic differences of community-level social vulnerability impact on pediatric thyroid cancer diagnosis and surveillance.</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Setting: </strong>United States.</p><p><strong>Methods: </strong>This retrospective analysis of 4324 pediatric thyroid cancer patients diagnosed between 1975 and 2017 from the Surveillance-Epidemiology-End Results (SEER) data set assessed overall social vulnerability aggregated from 15 different social vulnerabilities of health of socioeconomic status, minority-language status, household composition, and housing-transportation from the social vulnerability index (SVI). Social vulnerability scores of each category were matched to patients across US counties. Across racial-ethnic strata (non-Hispanic-white/non-white), age-adjusted regression analyses assessed surveillance period, lymph node metastasis, and number of primary tumors with increasing social vulnerability scores.</p><p><strong>Results: </strong>For non-Hispanic-white (n = 2666) and non-white (n = 1658) pediatric thyroid cancer patients, surveillance times at the lowest and highest-total SVI levels were higher among white (162.92 and 108.02 months, respectively) compared to non-white patients (117.64; 96.96). For lymph node metastasis, increasing SVI was associated with increased occurrence among non-white pediatric thyroid cancer patients (odds ratio [OR] 1.16, 95% CI 1.05-1.27) but not among white patients (0.96, 0.89-1.03). For multiple primary tumors on presentation, no significant differences were observed across both race-ethnic groups.</p><p><strong>Conclusion: </strong>Increasing community-level social vulnerability correlated with worse pediatric thyroid cancer surveillance, especially for non-white pediatric thyroid cancer patients in diagnostic and care outcomes. Through assessing upstream and downstream effects of social vulnerability on pediatric thyroid cancer patients, this multilevel approach allows nuanced considerations of one's individual racial-ethnic identity and their community to elucidate how non-clinical factors have disproportionate effects on the diagnosis of pediatric thyroid cancers.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70298"},"PeriodicalIF":1.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Nasal Mucus Metabolites in Chronic Rhinosinusitis With and Without Polyps and Healthy Controls.","authors":"Michael F Armstrong, Kathleen R Bartemes, Danielle E Hunter, Marisa D Griesel, Stephen G Voss, Garret W Choby, Carlos D Pinheiro Neto, John B Hagan, Rohit D Divekar, Erin K O'Brien","doi":"10.1002/oto2.70304","DOIUrl":"10.1002/oto2.70304","url":null,"abstract":"<p><strong>Objective: </strong>To identify differences in nasal mucus metabolites from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) and healthy controls.</p><p><strong>Study design: </strong>Cross-sectional.</p><p><strong>Setting: </strong>Single institution tertiary care facility.</p><p><strong>Methods: </strong>Patients were assigned to groups based on the appearance of normal mucosa (control [n = 5]), diseased mucosa ([CRSsNP] [n = 6]), or polypoid mucosa ([CRSwNP] [n = 4]), respectively. Mucus was collected on swabs. Nasal mucus metabolites were quantified via untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) for detection of all metabolites observable with the method. Metabolites in biochemical pathways implicated in sinonasal disease were further selected for analysis.</p><p><strong>Results: </strong>In the glycerophospholipid pathway, glycerophosphocholine and glycerol-3-phosphate were significantly elevated in controls (C) compared to the CRSwNP and CRSsNP groups (false discovery rate [FDR] = 0.03, C vs CRSwNP fold change [FC] = 3.83, C vs CRSsNP FC = 3.92 and FDR = 0.02, C vs CRSwNP FC = 3.05, C vs CRSsNP FC = 3.50, respectively). In the sphingolipid pathway, C24-OH sulfatide and dihydroceramide were significantly elevated in CRSwNP compared to CRSsNP and control mucus (FDR = 0.01, CRSwNP vs C FC = 146.75, CRSsNP vs C FC = 45.55, CRSwNP vs CRSsNP FC = 3.22 and FDR = 0.05, CRSwNP vs C FC = 4.40, CRSwNP vs CRSsNP FC = 2.72, respectively).</p><p><strong>Conclusion: </strong>Glycerophosphocholine and sphingolipid nasal mucus metabolites differed between patients with subtypes of CRS and controls. Nasal mucus metabolites may aid in differentiating subtypes of sinusitis.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70304"},"PeriodicalIF":1.6,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Complications of Orbital Floor Reconstructive Implants Using the MAUDE Database.","authors":"Emily S Sagalow, Caroline Liu, Samir Alkhouri, Harry H Ching","doi":"10.1002/oto2.70301","DOIUrl":"10.1002/oto2.70301","url":null,"abstract":"<p><strong>Objective: </strong>Orbital floor fractures are commonly treated with alloplastic implants, yet comparative safety data on implant materials remain limited. This study evaluates the adverse event (AE) profiles of commonly used orbital floor implants using a national device surveillance database.</p><p><strong>Study design: </strong>Retrospective database analysis.</p><p><strong>Setting: </strong>Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database.</p><p><strong>Methods: </strong>The MAUDE database was queried for AEs related to 13 orbital floor reconstructive implants from 7 manufacturers. Reported events were categorized by implant type and classified as malfunction, injury, or other.</p><p><strong>Results: </strong>A total of 90 AEs were identified across 4 implant types. Porous polyethylene SynPor® accounted for 69 events (76.7%), followed by porous polyethylene MEDPOR TITAN® with 15 (18.1%), porous polyethylene Su-Por® with 4 (4.8%), and smooth nylon foil SupraFOIL® with 2 (2.4%). Most AEs were categorized as malfunctions (n = 64, 77.1%), while 19 (21.1%) were reported as injuries. No malfunctions resulted in patient harm. All reported cases of implant infection or extrusion occurred with polyethylene implants. Overall, 97.6% of AEs involved polyethylene-based devices. No AEs were reported for titanium, poly-l/ dl-lactide, polycaprolactone, or PDS implants.</p><p><strong>Conclusion: </strong>Within the MAUDE database, AEs were most frequently reported for porous polyethylene implants. These findings represent the first systematic characterization of MAUDE-reported AEs for orbital floor implants and identify porous polyethylene as the predominant implant type captured in national postmarket surveillance. Prospective comparative studies are needed to evaluate material-specific complication rates and further guide implant selection.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70301"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13568600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Feature of Nasal Cavity for Endoscopic Endonasal Skull Base Surgery in Patients With GHoma.","authors":"Tomoharu Suzuki, Noritaka Komune, Yusuke Miyamoto, Daisuke Kuga, Yuhei Sangatsuda, Ryota Higuchi, Yuichi Saito, Daisuke Murakami, Koji Yoshimoto, Takashi Nakagawa","doi":"10.1002/oto2.70297","DOIUrl":"10.1002/oto2.70297","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic endonasal skull base surgery (EESS) is widely performed for pituitary tumors. In growth hormone-secreting adenomas (GHomas), the procedure is technically more demanding than for other pituitary neuroendocrine tumor (PitNET) subtypes due to restricted instrument maneuverability. Few studies have evaluated the influence of nasal cavity morphology on this difficulty.</p><p><strong>Objective: </strong>To identify anatomical factors contributing to the technical challenges of EESS for GHomas by comparing nasal cavity structures between GHoma and non-GHoma PitNET patients.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Tertiary referral center with a collaborative skull base team of neurosurgery and otolaryngology.</p><p><strong>Methods: </strong>Computed tomography (CT) images of 28 GHoma and 104 non-GHoma PitNET patients who underwent EESS between August 2018 and April 2024 were analyzed. Measurements included inter-vidian canal distance, nasolacrimal duct opening width, inferior turbinate width, piriform aperture width, sphenopalatine foramen width, inter-carotid artery distance, skull base-to-hard palate distance, anterior nasal spine-to-clivus distance, and anterior sphenoid wall-to-clivus distance. Comparisons were performed using Student's <i>t</i>-test.</p><p><strong>Results: </strong>GHoma patients showed significantly greater nasolacrimal duct opening width, piriform aperture width, and anterior nasal spine-to-clivus distance (<i>P</i> < .05). Vertical-to-horizontal ratios did not differ significantly. However, the inter-carotid artery distance and the ratios of inter-carotid distances to the anterior nasal spine-to-clivus distance were significantly smaller in GHomas.</p><p><strong>Conclusion: </strong>GHoma patients possess generally larger sinonasal dimensions, yet a narrower paraclival inter-carotid space limit surgical maneuverability. These CT-based anatomical differences may have potential implications for preoperative anatomical assessment in patients with GHomas.</p><p><strong>Level of evidence: </strong>IV.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70297"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Nebulized Tranexamic Acid for Acute Secondary Posttonsillectomy Hemorrhage.","authors":"Chloe M Jones, Donald H Solomon, Bailey Balouch, Lucia D Garcia, Yekaterina Shapiro","doi":"10.1002/oto2.70296","DOIUrl":"10.1002/oto2.70296","url":null,"abstract":"<p><strong>Objectives: </strong>Determine the efficacy of nebulized TXA for secondary posttonsillectomy hemorrhage.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary care medical center.</p><p><strong>Methods: </strong>All adult and pediatric patients who presented with active posttonsillectomy hemorrhage >24 hours posttonsillectomy treated at our tertiary care institution between December 2014 and July 2025 were included. Patients who were not actively bleeding on presentation were excluded. Outcomes were compared between patients who received nebulized TXA and those who did not. Outcomes included need for operative intervention, length of hospital stay, and recurrent hemorrhage rate. Univariate statistical analysis was performed using SPSS.</p><p><strong>Results: </strong>There were 101 patients included and 57 received nebulized TXA. All included patients were actively bleeding at the time of initial presentation. Hemostasis was achieved in 84.2% of the 57 patients following administration of nebulized TXA. Patients who received nebulized TXA were significantly less likely to require operative intervention (OR = 0.370 [0.157-0.873]). If operative intervention was required following administration of nebulized TXA (54.9%), the time from presentation to operative intervention was significantly longer (408 ± 324 minutes vs 249 ± 293 minutes, <i>P</i> = .045). Neither hospital length of stay (1.2 ± 1.1 vs 1.5 ± 1.4 days, <i>P</i> = .148) or readmission rate for recurrent posttonsillectomy hemorrhage (7.0% vs 13.6%, <i>P</i> = .283) differed significantly between groups. No adverse effects of nebulized TXA were identified.</p><p><strong>Conclusion: </strong>Administration of nebulized TXA is a safe and effective strategy for acute stabilization of secondary posttonsillectomy hemorrhage. Nebulized TXA reduced the rate of operative intervention for secondary posttonsillectomy hemorrhage and increased the time until intervention was required.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70296"},"PeriodicalIF":1.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nasal Obstruction and Mouth Taping on Sleep Apnea Indicators: Systematic Review and Meta-Analysis.","authors":"Nawaf A Alshehri, Nada F Alsaif, Abdullah N Abdulrazaq, Raaoum M Jabor, Ahmed A Al-Sayed","doi":"10.1002/oto2.70294","DOIUrl":"10.1002/oto2.70294","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of nasal obstruction on obstructive sleep apnea (OSA) indicators and summarize the limited available data on mouth taping during sleep.</p><p><strong>Data sources: </strong>A systematic search was conducted in October 2024, encompassing 5 electronic databases: PubMed, MEDLINE, Web of Science, Cochrane, and CINAHL, to evaluate the impact of breathing routes on OSA indicators.</p><p><strong>Review methods: </strong>Eligible studies included those that induced nasal obstruction either non-surgically (eg, experimental studies or postintervention for epistaxis) or surgically (eg, postseptoturbinoplasty) and their impact on reported sleep apnea indicators, such as Apnea-Hypopnea Index (AHI), Oxygen Desaturation Index (ODI), mean and nadir oxygen saturation. A Meta-analysis was conducted on studies of nasal obstruction. Due to limited data, no meta-analysis was performed for mouth taping; only 2 studies were narratively reviewed.</p><p><strong>Results: </strong>Nasal obstruction was associated with a clinically significant increase in AHI (+13.78 events/h) and ODI (+7.45 events/h), alongside a modest nonclinically significant decrease in the average (-0.70%) and nadir (-1.75%) SpO₂. Conversely, a narrative review of two studies on mouth taping found it reduced AHI in patients with mild OSA. The heterogeneity among studies limits the generalizability of these data.</p><p><strong>Conclusion: </strong>Nasal obstruction, whether induced non-surgically or in surgical settings, was associated with worsening of OSA indicators and may precipitate OSA-like abnormalities in previously healthy individuals. These findings underscore the importance of nasal breathing and support further investigation into the breathing route as a modifiable factor in sleep-disordered breathing.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70294"},"PeriodicalIF":1.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health and Sleep Outcomes Among Patients Diagnosed With Chronic Cough.","authors":"Andrew Meci, Emily N Milarachi, John P Gniady","doi":"10.1002/oto2.70291","DOIUrl":"10.1002/oto2.70291","url":null,"abstract":"<p><strong>Objective: </strong>Chronic cough is a complex, multi-factorial condition. Past studies have associated chronic cough with a degraded quality of life, namely related to psychological and sleep outcomes. We investigated the association between chronic cough and later diagnosis with mental health and sleep disorders using a large database.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>TriNetX research database.</p><p><strong>Methods: </strong>A retrospective cohort analysis was conducted using the TriNetX research database. Patients aged ≥18 years with chronic cough diagnosed from 2008 to 2018 and no recent history of mental health or sleep disorders were included and compared to a matched control cohort. Primary outcomes were 5-year diagnoses with sleep disorders, depression, and anxiety. Secondary outcomes included rates of interaction with the healthcare system, other mental health diagnoses, and usage of psychological medications and sleep devices.</p><p><strong>Results: </strong>Of 65,442 included patients with chronic cough, mean age was 54.5 ± 15.3 and patients were 60.8% female, 75.2% white, and 86.5% not Hispanic/Latino. After demographic matching, patients with chronic cough had significantly higher rates of smoking, obesity, asthma, and GERD. Patients were at significantly higher risks of developing sleep disorders (RR 1.58, <i>P</i> < .01), mental health diagnoses (RR 1.33, <i>P</i> < .01), and receiving anti-reflux, antidepressant, and CPAP treatments (<i>P</i> < .01 for all).</p><p><strong>Conclusion: </strong>Chronic cough diagnosis is associated with increased risk of later development of anxiety, depression, and disordered sleep. This is the largest study to date examining the burden of chronic cough alongside associated outcomes. Future studies will further investigate these associations and investigate improved patient care models.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70291"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13512043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Extremity Outcomes in Radial Forearm Free Flap Reconstruction of the Head and Neck.","authors":"Brooke B Swain, Sindhura Sridhar, Whitney Jin, Robert J Sinard, Kyle Mannion, Alexander J Langerman, Eben L Rosenthal, Michael C Topf, Sarah L Rohde","doi":"10.1002/oto2.70283","DOIUrl":"10.1002/oto2.70283","url":null,"abstract":"<p><strong>Objective: </strong>Fasciocutaneous radial forearm free flaps (RFFF) are widely used for head and neck soft tissue reconstruction. Osteocutaneous radial forearm free flaps (OCRFFF) enable bony reconstruction, but concerns for donor site morbidity have limited their use. Long-term donor site outcomes following OCRFFF remain understudied.</p><p><strong>Study design: </strong>Cross-sectional.</p><p><strong>Setting: </strong>Single-institution.</p><p><strong>Methods: </strong>Patients who underwent RFFF or OCRFFF between 2010 and 2023 were surveyed by phone. Upper extremity function was assessed using the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) survey (0-100 scale, higher scores indicate greater disability). Patients who were non-verbal or lacked follow-up after 2021 were excluded. QuickDASH scores were analyzed using Wilcoxon rank-sum test. Univariable linear regressions assessed clinical associations.</p><p><strong>Results: </strong>Survey response rate was 21.7%. The cohort included 26 RFFF, 14 OCRFFF, and 5 patients with multiple radial forearm flaps. At a median time of 3.25 years postoperatively (IQR: 2.2-5.6), OCRFFF patients had higher mean QuickDASH scores (21.6) than RFFF (10.7), suggesting greater functional limitation in OCRFFF cases (<i>P</i> = .12). Overall impairment remained low. OCRFFF patients reported greater difficulties compared to RFFF regarding jar opening (2.4 vs 1.6; <i>P</i> = 0.01), back washing (2.0 vs 1.3; <i>P</i> = .03), and recreational activities (2.5 vs 1.4; <i>P</i> = .02). History of depression was associated with higher QuickDASH scores (coef 12.7, 95% CI: 1.23-24.48).</p><p><strong>Conclusions: </strong>OCRFFF patients reported greater difficulty in certain task-specific activities compared to RFFF, but overall donor site impairment following forearm free flap reconstruction is minimal. History of depression is associated with worse self-reported upper extremity function.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"10 3","pages":"e70283"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13512044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}