OTO Open最新文献

{"title":"Impact of Cisplatin on Hearing: Analysis Using PTA, High-Frequency Audiometry, DPOAE, and Speech-in-Noise Test.","authors":"Juhi Irfana Basheer, Ramaswamy Balakrishnan, Poorvi V Sharma, Madikeri Mohan Kishan, Karthik Udupa","doi":"10.1002/oto2.70097","DOIUrl":"10.1002/oto2.70097","url":null,"abstract":"<p><strong>Objective: </strong>To assess hearing loss in patients with cancer receiving cisplatin-based chemotherapy using high-frequency pure tone average (HFPTA), distortion product otoacoustic emissions (DPOAEs), and the speech-in-noise (SPIN) test, and to identify associated factors.</p><p><strong>Study design: </strong>Prospective study.</p><p><strong>Setting: </strong>Tertiary care hospital.</p><p><strong>Methods: </strong>Patients scheduled for cisplatin chemotherapy were included in the study. Audiological assessments, including HFPTA, DPOAE, and SPIN tests, were conducted at baseline, after two cycles, and after four cycles of chemotherapy. Clinical data were also analyzed.</p><p><strong>Results: </strong>One-third of the population was aged between 51 and 60 years. Higher cumulative doses of cisplatin were administered for bladder and head and neck cancers, reaching up to 3200 mg over four cycles. Most patients had normal hearing at baseline, but HFPTA detected significant hearing loss at various frequencies (8-20 kHz) over follow-ups. DPOAE showed increased negative emissions over time. A weak, negative correlation between cisplatin dose and extended high-frequency audiometry (maximum -0.311 at 18 kHz) and DPOAE (maximum -0.173 at 1500 Hz) was observed. The SPIN test suggested reduced SPIN performance with treatment progression. However, correlation with cisplatin doses was not statistically significant.</p><p><strong>Conclusion: </strong>The study underscores the importance of integrated audiological monitoring in detecting early ototoxicity in cisplatin-treated patients, emphasizing the need for periodic auditory assessments during chemotherapy. SPIN test is a simple tool offering significant potential for ototoxicity monitoring.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70097"},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Speech and Swallowing Dysfunction and Intervention Among Individuals With Myasthenia Gravis.","authors":"Tyler J Gallagher, Chloe Santa Maria, Michael M Johns","doi":"10.1002/oto2.70077","DOIUrl":"10.1002/oto2.70077","url":null,"abstract":"<p><strong>Objective: </strong>To examine the prevalence of dysphonia and dysphagia among individuals with myasthenia gravis (MG) and the frequency of utilization of speech and swallow evaluation and therapy.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>TriNetX US Collaborative Network.</p><p><strong>Methods: </strong>The cohort includes adults (≥18 years) with and without MG diagnosis. Propensity score matching was used before generating odds ratios (OR) of receiving speech and swallow diagnoses including dysarthria, dysphonia, dysphagia, and aspiration pneumonia. Subsequently, rates of individuals with MG receiving voice and swallow evaluation and therapy were analyzed.</p><p><strong>Results: </strong>In this cohort, the prevalence of voice, speech, and swallowing pathology was higher in those with MG than without, including aspiration pneumonia (3.7% vs 0.7%), dysarthria (9.2% vs 0.5%), dysphonia (4.4% vs 1.2%), and dysphagia (24.9% vs 4.7%). ORs for diagnosis of each type of pathology were higher after MG diagnosis, including for aspiration pneumonia (OR: 2.69 [95% confidence interval, CI: 1.95-3.70]), dysarthria (OR: 9.28 [95% CI: 6.67-12.92]), dysphonia (OR: 2.63 [95% CI: 1.97-3.53]), and dysphagia (OR: 4.18 [95% CI: 3.62-4.83]). Finally, the rate of receiving a swallow and/or voice evaluation and/or therapy was low among all individuals with MG (16.9%) but higher among those with MG with any speech or swallow symptom (47.0%), MG with dysarthria and/or dysphonia (56.2%), and MG with dysphagia and/or aspiration pneumonia (49.0%).</p><p><strong>Conclusion: </strong>Rates of dysarthria, dysphonia, dysphagia, and aspiration pneumonia were far more common among those with MG than without, but formal speech and/or swallow evaluation was not routine. These findings suggest a need for more routine speech-language pathology evaluation among individuals with MG.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70077"},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Diagnostic Concordance of Low-cost Endoscopic Remote Consultation Versus Standard Otolaryngology Evaluation.","authors":"Manuela Restrepo Peláez, Paola Herrera Noreña, Tania Margarita Salgado Gómez, Ingri Julieth Patiño Ariza, Carlos Stiven Zúñiga Bravo, Sebastián Orozco Arteaga","doi":"10.1002/oto2.70072","DOIUrl":"10.1002/oto2.70072","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the diagnostic concordance between findings obtained using a low-cost endoscope during telepresence evaluations and those obtained through conventional otolaryngology consultations.</p><p><strong>Study design: </strong>An observational cross-sectional study was conducted between September 2022 and October 2023.</p><p><strong>Setting: </strong>Second-level clinic providing in-person otolaryngology consultations for patients aged 18 and older.</p><p><strong>Methods: </strong>A total of 223 evaluations were performed on 217 adult patients, comparing in-person assessments with remote evaluations using a low-cost otoendoscopic device. Diagnostic concordance was assessed for 7 otolaryngological conditions: tympanic perforation, myringosclerosis, signs of external otitis, middle ear effusion, turbinate hypertrophy, septal deviation, and tonsillar hypertrophy. Statistical analysis included the calculation of Cohen's <i>κ</i> coefficient and diagnostic performance measures.</p><p><strong>Results: </strong>The endoscopic evaluation demonstrated high diagnostic concordance for ear and oral cavity assessments, particularly for tympanic perforation and signs of external otitis (<i>κ</i> of 1 and 0.93, respectively). Conversely, low concordance was observed for nasal findings such as turbinate hypertrophy and septal deviation (<i>κ</i> of 0.07 and 0.11, respectively). Limitations in image resolution and data capture of the low-cost device were identified.</p><p><strong>Conclusion: </strong>The low-cost endoscope used in telepresence otolaryngology consultations is effective for evaluating ear and oral cavity findings but shows limitations in nasal cavity assessments. Telemedicine in otolaryngology can reduce health care access barriers in settings with limited availability of specialized services. This study underscores the need for continued research and development of more precise diagnostic devices in otolaryngology.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70072"},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Knowledge and Factors Associated With Familiarity of Treatments for Rhinosinusitis.","authors":"Tyler J Gallagher, Rishabh Shah, Michelle Koh, Catherine Julien, Matthew E Lin, Kevin Hur","doi":"10.1002/oto2.70091","DOIUrl":"https://doi.org/10.1002/oto2.70091","url":null,"abstract":"<p><strong>Objective: </strong>Rhinosinusitis is a common otolaryngologic condition with many over-the-counter (OTC), prescription, and surgical treatment options. This study seeks to evaluate public familiarity with treatments for rhinosinusitis.</p><p><strong>Study design: </strong>Cross-sectional survey.</p><p><strong>Setting: </strong>US adult (≥18 years) online survey respondents.</p><p><strong>Methods: </strong>A cross-sectional survey was administered to US adults via ResearchMatch. Questions included a demographic questionnaire, validated nasal obstruction surveys, personal history of chronic rhinosinusitis (CRS), as well as familiarity with various treatments for rhinosinusitis (5-point Likert scale). Descriptive statistics were utilized to describe results, and multivariable ordinal regression was utilized to describe factors associated with knowledge of any treatment and over-the-counter treatments.</p><p><strong>Results: </strong>The cohort (n = 1086) was primarily female (75.7%), white (80.3%), married (47.5%), and college educated (36.6%). Highest rates of familiarity with treatment were reported for antihistamines (80%), decongestants (80%), and nasal corticosteroids (78%). Factors associated with knowledge of any rhinosinusitis treatment included age (odds ratio [OR]: 0.99 [95% confidence interval [CI]: 0.98-0.99]), literacy score (OR: 0.76 [95% CI: 0.71-0.82]), CRS diagnosis (OR: 2.91 [95% CI: 2.25-3.75]), and symptomatic score. Factors associated with knowledge of OTC treatments included female gender (OR: 2.40 [95% CI: 1.82-3.16]), literacy score (OR: 0.77 [95% CI: 0.72-0.83]), CRS diagnosis (OR: 2.94 [95% CI: 2.25-3.83]), and symptomatic score.</p><p><strong>Conclusion: </strong>Individuals at risk for having lower familiarity with treatment options include males, older individuals, and those with lower health literacy. Future studies should evaluate the impact that public knowledge and primary care provider knowledge of treatment options for rhinosinusitis has on outcomes of rhinosinusitis.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70091"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophilic Pseudotumor Arising in Buccal Space Presenting as Rapidly Progressive Facial Swelling: A Diagnostic Dilemma.","authors":"Asimakis D Asimakopoulos, Eugène Panosetti","doi":"10.1002/oto2.70081","DOIUrl":"https://doi.org/10.1002/oto2.70081","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70081"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silk Suture Hypersensitivity Masquerading as Recurrent Hypoglossal Nerve Stimulator Infections.","authors":"John J Ceremsak, Basil M Kahwash, Holly Budnick, David T Kent","doi":"10.1002/oto2.70058","DOIUrl":"10.1002/oto2.70058","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70058"},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Gender Distribution in Academic Rhinology.","authors":"Alison J Yu, Stephanie Wong, Kevin Herrera, Daniel Palmieri, Bozena Wrobel, Tamara Chambers, Nadia Chan","doi":"10.1002/oto2.70092","DOIUrl":"10.1002/oto2.70092","url":null,"abstract":"<p><strong>Objective: </strong>Women have been underrepresented in academic medicine and surgical fields. This study aimed to describe the gender distribution in academic rhinology and investigate otolaryngology departmental factors associated with female rhinologists representation.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>American Medical Association (AMA) FREIDA database, American Rhinologic Society database, and online search.</p><p><strong>Methods: </strong>We identified fellowship-trained rhinologists from institutional searches of residency programs identified from the AMA FREIDA database. Demographic and academic data of each rhinologist were extracted from online search. Departmental characteristics were obtained from the FREIDA database and institutional websites. The associations between female rhinologists representation and departmental factors were assessed using logistic regression analyses.</p><p><strong>Results: </strong>Among 224 fellowship-trained rhinologists, female comprised 26.8%. There were more female assistant professors (55.0% vs 39.6%) and fewer full professors (10.0% vs. 24.4%) than their male counterparts (<i>P</i> = .046). The mean <i>H</i> index was lower for female than male rhinologists among those over 5 years in practice (20.5 vs 33.0, <i>P</i> = .029). In the multivariate analysis, female rhinologists were more likely to be found in departments with greater proportions of female faculty (adjusted odds ratio 1.08 [95% confidence interval 1.04-1.12], <i>P</i> < .001).</p><p><strong>Conclusion: </strong>The proportion of female rhinologists decreased significantly as they advanced through academic rank. The main driver for female rhinologists representation is the increased number of female faculty in the department. There should be increased efforts to promote female mentorship and women in leadership positions.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70092"},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of Otologic and Nasal Symptoms in Primary Ciliary Dyskinesia Throughout Childhood.","authors":"Isabelle Dagher, Adam J Kimple, Thomas W Ferkol, Scott D Sagel, Sharon D Dell, Carlos E Milla, Lang Li, Feng-Chang Lin, Kelli M Sullivan, Maimoona A Zariwala, Michael R Knowles, Margaret Rosenfeld, Margaret W Leigh, Stephanie D Davis","doi":"10.1002/oto2.70079","DOIUrl":"10.1002/oto2.70079","url":null,"abstract":"<p><strong>Objective: </strong>Primary ciliary dyskinesia (PCD) is characterized by upper and lower airway disease. Multiple studies have demonstrated the progression of pulmonary disease; however, longitudinal changes in the otologic and nasal symptoms have not been well described in patients. This study defines age-related prevalence, age of onset, and age-related trends in self-reported otologic and sinonasal comorbidities in individuals with PCD.</p><p><strong>Study design: </strong>A prospective, longitudinal, multicenter, observational study spanning up to 12 years.</p><p><strong>Setting: </strong>Six PCD centers in North America.</p><p><strong>Methods: </strong>Inclusion criteria were <19 years of age and a confirmed diagnosis of PCD based on electron microscopy and/or genetics. A standardized medical history questionnaire and physical exam were completed during each study visit. Descriptive statistics were performed for the entire cohort as well as for subgroups based on ciliary ultrastructure.</p><p><strong>Results: </strong>A total of 147 participants were followed for an average of 7.6 ± 3.2 years. Pressure equalization tubes (PETs) were placed in 80%, transient hearing loss was reported in 68%, and persistent hearing loss was reported in 30%. Hearing aids and speech therapy were utilized by 8% and 27%, respectively. PETs were placed earlier in those with inner dynein arm/microtubular disorganization defects than those with outer dynein arm defects. Participants reported chronic nasal congestion in 97%, sinusitis in 87%, and 35% underwent >1 sinus surgery.</p><p><strong>Conclusion: </strong>There is a high prevalence of reported otologic and sinonasal morbidity among people with PCD that begins during early childhood and persists. Further analysis is indicated to evaluate differences over time among participants with varying ultrastructural defects.</p><p><strong>Level of evidence: </strong>Level 2.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70079"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends in Chronic Rhinosinusitis and Inpatient Sinus Surgery in Adults with Cystic Fibrosis.","authors":"Roy W Qu, Nihal Punjabi, Wilson P Lao, Kristin A Seiberling, Christopher A Church","doi":"10.1002/oto2.70064","DOIUrl":"10.1002/oto2.70064","url":null,"abstract":"<p><strong>Objective: </strong>Given the recent dramatic changes in medical therapy for cystic fibrosis (CF), this study aims to describe temporal changes in chronic rhinosinusitis (CRS) and endoscopic sinus surgery (ESS) rates.</p><p><strong>Methods: </strong>National Inpatient Sample (2004-2019; weighted estimates for 119,067 pediatric and 202,407 adult patients) was used to analyze adult (age ≥18 years) and pediatric patients with CF with pulmonary manifestations. Comorbid CRS, ESS rates, and extended length of stay (LOS, ≥75th percentile) were analyzed.</p><p><strong>Results: </strong>The rate of CRS in both pediatric (14.1% vs 21.1%, <i>P</i> < .001) and adult (16.5% vs 40.9%, <i>P</i> < .001) patients increased. Rate of ESS in pediatric patients with CRS decreased from 25.3% to 3.4% (<i>P</i> < .001). A similar decline occurred in adults with CRS (12.3% vs 3.6%, <i>P</i> < .001). In multivariate analysis from 2015 to 2019, ESS and extended LOS were associated with admission in the Western United States (<i>P</i> < .001). CRS (OR 1.14, <i>P</i> = .002) and ESS (OR 1.78, <i>P</i> = .002) were independent predictors of extended LOS. Elective admission, primary insurance, race, and hospital teaching/location were significantly associated with ESS and extended LOS (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Despite the increased prevalence of CRS in adults and pediatric patients with CF, rates of inpatient ESS have declined from 2004 to 2019. Patient and hospital factors affect undergoing ESS in 2015 to 2019. CRS and ESS are associated with extended LOS in recent years.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70064"},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closure of Non-malignant Acquired Tracheoesophageal Fistula With Anterolateral Thigh Free Flap: A Case Report.","authors":"Sindhura Sridhar, Aatin K Dhanda, Nadia G Mohyuddin, Joshua J Kain","doi":"10.1002/oto2.70088","DOIUrl":"10.1002/oto2.70088","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"9 1","pages":"e70088"},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}