Oral diseases最新文献_第8页

Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis. 人参皂苷 Rb1 通过抑制巨噬细胞的嗜热作用改善根尖牙周炎。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-08-18 DOI: 10.1111/odi.15103

Xiaoyue Guan, Rui Zhao, Yuting Wang, Wenlan Li, Lifei Pan, Yao Yang, Wenli Mu, Tie Zhou Hou

{"title":"Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis.","authors":"Xiaoyue Guan, Rui Zhao, Yuting Wang, Wenlan Li, Lifei Pan, Yao Yang, Wenli Mu, Tie Zhou Hou","doi":"10.1111/odi.15103","DOIUrl":"10.1111/odi.15103","url":null,"abstract":"Objectives: The objectives of current study were to investigate the role and related mechanism of Ginsenoside Rb1 (GRb1) on regulating apical periodontitis (AP) prognosis.Materials and methods: Clinical specimens were used to determine the involvement of calcium overload-induced macrophage pyroptosis in periapical tissues. Next, a calcium ion-chelating agent (BAPTA-AM) was applied to detect the suppression of intracellular calcium overload in macrophage pyroptosis. Then, network pharmacology, western blot (WB) analysis, and Fluo-4 calcium assay were conducted to explore the role of GRb1 on intracellular calcium overload. To gain a better understanding of GRb1 in calcium overload-induced macrophage pyroptosis linked AP, GRb1-treated AP models were established.Results: We discovered clinically and experimentally that calcium overload-dependent macrophage pyroptosis is involved in AP pathogenesis, and reducing calcium overload greatly decreased macrophage pyroptosis in an AP cell model. Next, based on GRb1's inhibitory role in aberrant intracellular calcium accumulation, we discovered that GRb1 alleviates AP by suppressing calcium-dependent macrophage pyroptosis in both in vitro and in vivo models.Conclusions: GRb1 is an effective therapeutic strategy to rescue the periapical tissues from inflammation due to its anti-pyroptosis function. Thus, the present study supports further investigation of GRb1 as an adjuvant therapy for AP.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"541-554"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antifungal recombinant psoriasin of human origin effectively inhibits fungal growth on denture base. 源于人类的抗真菌重组牛皮癣素能有效抑制义齿基托上的真菌生长。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-07-28 DOI: 10.1111/odi.15092

Lucia Adriana Lifshits, Edward Bronshtein, May Attias, Yoav Breuer, Adi Cohen, Matan Gabay, Marina Sova, Evgeny Weinberg, Eran Zenziper, Daniel Z Bar, Nir Sterer, Maayan Gal

{"title":"Antifungal recombinant psoriasin of human origin effectively inhibits fungal growth on denture base.","authors":"Lucia Adriana Lifshits, Edward Bronshtein, May Attias, Yoav Breuer, Adi Cohen, Matan Gabay, Marina Sova, Evgeny Weinberg, Eran Zenziper, Daniel Z Bar, Nir Sterer, Maayan Gal","doi":"10.1111/odi.15092","DOIUrl":"10.1111/odi.15092","url":null,"abstract":"Objective: To evaluate the efficacy of recombinant psoriasin as a novel treatment for oral candidiasis by eliminating Candida albicans growth on polymethyl methacrylate denture base.Materials and methods: Recombinant psoriasin protein was expressed and purified from E. coli, and Candida growth was monitored in vitro with varying concentrations of psoriasin. Subsequently, denture-base polymethyl methacrylate was immersed in psoriasin's solution or voriconazole, and fungal growth on the acrylic base and in the medium was examined by scanning electron microscopy and optical density, respectively. Cellular viability of HeLa and human gingival fibroblast cells treated with psoriasin was measured by methylene blue assay.Results: The findings reveal an effective antifungal activity of psoriasin, completely inhibiting Candida albicans growth in RPMI at a protein concentration above 400 nM. Immersing the polymethyl methacrylate with 50 μM psoriasin completely eradicates fungal growth. Psoriasin has low cytotoxicity in HeLa cells at a concentration higher than 12 μM and no toxic effect on human gingival fibroblasts.Conclusions: This study marks psoriasin as an effective alternative to conventional antifungal treatments for denture stomatitis and a safe alternative to chemical antifungals in dental medicine and beyond.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"672-681"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold atmospheric plasma activated media selectively affects human head and neck cancer cell lines. 冷大气等离子体活化介质可选择性地影响人类头颈癌细胞株。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-09-24 DOI: 10.1111/odi.15120

Viviana di Giacomo, Marwa Balaha, Morena Pinti, Maria Carmela Di Marcantonio, Ilaria Cela, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Gabriella Mincione, Gianluca Sala, Miryam Perrucci, Marcello Locatelli, Vittoria Perrotti

{"title":"Cold atmospheric plasma activated media selectively affects human head and neck cancer cell lines.","authors":"Viviana di Giacomo, Marwa Balaha, Morena Pinti, Maria Carmela Di Marcantonio, Ilaria Cela, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Gabriella Mincione, Gianluca Sala, Miryam Perrucci, Marcello Locatelli, Vittoria Perrotti","doi":"10.1111/odi.15120","DOIUrl":"10.1111/odi.15120","url":null,"abstract":"Objective: Cold atmospheric plasma (CAP) is a novel approach for cancer treatment. It can be used to treat liquids-plasma-activated media (PAM)-which are then transferred to the target as an exogenous source of reactive oxygen and nitrogen species (RONS). The present study aimed at chemically characterizing different PAM and assessing their in vitro selectivity against head and neck cancer cells (HNC).Methods: PAM were obtained by exposing 2 and 5 mL of cell culture medium to CAP for 5, 10 and 20 min at a 6 mm working distance. Anions kinetics was evaluated by ion chromatography. Cell proliferation inhibition, apoptosis occurrence, and cell cycle modifications were assessed by MTS and flow cytometry, on human epidermal keratinocyte (HaCaT) and HNC cell lines HSC3, HSC4 and A253.Results: The 2 mL conditions showed a significant reduction in cell proliferation whereas for the 5 mL the effect was milder, but the time-dependence was more evident. HaCaT were unaffected by the 5 mL PAM, indicating a selectivity for cancer cells.Conclusions: The media chemical composition modified by CAP exposure influenced cell proliferation by modulating cell cycle and inducing apoptosis in cancer cells, without affecting normal cells.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"401-416"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal micronutrient biomarkers and risk of non-syndromic cleft lip/palate: A case-control study. 母体微量营养素生物标志物与非综合征唇腭裂风险：病例对照研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-07-22 DOI: 10.1111/odi.15079

Araya Pisek, Christy M McKinney, Benja Muktabhant, Waranuch Pitiphat

{"title":"Maternal micronutrient biomarkers and risk of non-syndromic cleft lip/palate: A case-control study.","authors":"Araya Pisek, Christy M McKinney, Benja Muktabhant, Waranuch Pitiphat","doi":"10.1111/odi.15079","DOIUrl":"10.1111/odi.15079","url":null,"abstract":"Objective: This case-control study investigated the associations between maternal plasma vitamin B12, homocysteine, and red blood cell (RBC) folate levels and the risk of cleft lip with or without cleft palate (CL/P) in offspring.Subjects and methods: The study compared 94 mothers and children with non-syndromic CL/P from a teaching hospital in Thailand to 94 mother-infant controls from local well-baby clinics, frequency-matched by birth date and mother's education. Data included anthropometric measurements, blood sample analyses, and a questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) estimated the associations through multiple logistic regression, adjusting for confounders.Results: Mothers with higher plasma vitamin B12 levels had a lower risk of having a child with CL/P compared to those in the lowest quartile. This association was more pronounced among mothers without a family history of orofacial clefts and those who were not underweight. Conversely, elevated homocysteine levels, a marker of impaired B vitamin metabolism, increased the risk of CL/P. No association was found between RBC folate and CL/P.Conclusion: Higher maternal vitamin B12 levels are associated with a reduced risk of CL/P, while elevated homocysteine levels may increase the risk.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"565-576"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulomatous ulcer affecting the hard and soft palate in a young patient. 一个年轻病人的软硬腭肉芽肿性溃疡。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1111/odi.15127

Isabel Schausltz Pereira Faustino, Leonardo Dos Santos Bayeh, Danillo Batista Silveira, Irineu Maia, Joab Cabral Ramos

引用次数: 0

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy. 牙龈卟啉单胞菌通过调节自噬促进口腔鳞状细胞癌的发展

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-22 DOI: 10.1111/odi.15157

Keyong Yuan, Shengming Xu, Guanglong Liu, Yong Han, Jingzhou Hu, Wuchang Zhang, Zhiyuan Zhang, Liu Liu, Zhengwei Huang, Yu Zhu, Shuli Liu

{"title":"Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy.","authors":"Keyong Yuan, Shengming Xu, Guanglong Liu, Yong Han, Jingzhou Hu, Wuchang Zhang, Zhiyuan Zhang, Liu Liu, Zhengwei Huang, Yu Zhu, Shuli Liu","doi":"10.1111/odi.15157","DOIUrl":"10.1111/odi.15157","url":null,"abstract":"Objectives: Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with various gastro-intestinal tract cancers. However, whether P. gingivalis can promote oral squamous cell carcinoma (OSCC) and the underlying mechanism associated with such promotion remain unclear.Materials and methods: In this study, OSCC xenograft models were used to evaluate the effects of P. gingivalis on tumor progression. The functional studies were done on several OSCC cell lines in vitro. P. gingivalis-specific 16S rRNA fluorescent in situ hybridization (FISH) was used to test its prevalence in clinical samples.Results: We found that P. gingivalis increased tumor volume and tumor growth in OSCC nude models. Functional studies demonstrated that P. gingivalis inhibited the apoptosis of OSCC cells by promoting cellular autophagy. P. gingivalis was more prevalent in FISH samples from patients with OSCC than from patients with leukoplakia or healthy subjects (70% vs. 47.2% vs. 33.3%, p = 0.045 and p < 0.001, respectively).Conclusion: These data suggest that P. gingivalis plays an accelerating role in OSCC progression and contributes to OSCC by enhancing the autophagy pathway to reduce carcinoma apoptosis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"492-502"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of Machine Learning Models for Predicting Tumor Progression in OSCC. 用于预测 OSCC 肿瘤进展的机器学习模型的开发与验证

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-27 DOI: 10.1111/odi.15159

Xueying Mei, Wenhao Luo, Wan Duan, Zhuming Guo, Xiaomei Lao, Sien Zhang, Le Yang, Bin Zeng, Jianbin Gong, Wei Deng, Guiqing Liao, Yujie Liang

{"title":"Development and Validation of Machine Learning Models for Predicting Tumor Progression in OSCC.","authors":"Xueying Mei, Wenhao Luo, Wan Duan, Zhuming Guo, Xiaomei Lao, Sien Zhang, Le Yang, Bin Zeng, Jianbin Gong, Wei Deng, Guiqing Liao, Yujie Liang","doi":"10.1111/odi.15159","DOIUrl":"10.1111/odi.15159","url":null,"abstract":"Objectives: Development of a prediction model using machine learning (ML) method for tumor progression in oral squamous cell carcinoma (OSCC) patients would provide risk estimation for individual patient outcomes.Patients and methods: This predictive modeling study was conducted of 1163 patients with OSCC from Hospital of Stomatology, SYSU and SYSU Cancer Center from March 2009 to October 2021. Clinical, pathological, and hematological features of the patients were collected. Six ML algorithms were explored, and model performance was assessed by accuracy, sensitivity, specificity, f1 score, and AUC. SHAP values were used to identify the variables with the greatest contribution to the model.Results: Among the 1163 patients (mean [SD] age, 55.36 [12.91] years), 563 are from development cohort and 600 are from validation cohort. The Logistic Regression algorithm outperformed all other models, with a sensitivity of 94.7% (68.2%), a specificity of 55.3% (63.7%), and the AUC of 0.76 ± 0.09 (0.723) in the development (validation) cohort. The most predictive feature was neutrophil count.Conclusion: This study demonstrated ML models can improve clinical prediction of oral squamous cell carcinoma progression through basic information of patients. These tools could be used to provide individual risk estimation and may help direct intervention.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"426-434"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial. 外用氟西萘胺对口腔扁平苔藓演变的影响：随机对照临床试验。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-14 DOI: 10.1111/odi.15156

Alessandro Polizzi, Gianluca Martino Tartaglia, Simona Santonocito, Angela Alibrandi, Anna Elisa Verzì, Gaetano Isola

{"title":"Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial.","authors":"Alessandro Polizzi, Gianluca Martino Tartaglia, Simona Santonocito, Angela Alibrandi, Anna Elisa Verzì, Gaetano Isola","doi":"10.1111/odi.15156","DOIUrl":"10.1111/odi.15156","url":null,"abstract":"Objective: To examine the impact of fluocinonide 0.05% gel formulation for the topical treatment of oral lichen planus (OLP).Methods: Through an RCT design, 47 patients with OLP were randomly allocated for topical OLP treatment with fluocinonide 0.05% (n = 23) or placebo (n = 24). Patients were examined for OLP symptoms, signs, disease severity, and extension score changes over 6-month follow-up.Results: After 6 months, in comparison with placebo, patients treated with fluocinonide experienced a significant reduction of OLP symptoms (p = 0.024), signs (p = 0.014), and OLP extension score (p = 0.028). The two-way ANOVA estimation models revealed that treatment with fluocinonide determined, at 6 months, a positive significant effect on the reduced OLP signs (p = 0.017), OLP symptoms (p = 0.026), and OLP extension score (p = 0.028). The multivariate regression analysis highlighted that anxiety, stress, and depression were significant predictors of every analyzed OLP outcome (p < 0.05 for each parameter) and that patients who had baseline anxiety, depression, and stress gained more benefits from fluocinonide at 6-month follow-up.Conclusions: Topical fluocinonide 0.05% was more efficacious compared to placebo in reducing OLP outcomes at 6-month follow-up. Anxiety, depression, and stress were significant predictors of OLP outcomes and positively impacted the treatment with fluocinonide at 6 months.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"510-521"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and clinical significance of tertiary lymphoid structures in OSCC. OSCC 中三级淋巴结构的特征和临床意义。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-07-24 DOI: 10.1111/odi.15080

Mianfeng Yao, Tianru Yang, Qiulan Li, Xinle Zhang, Ziran Zheng, Jiang Li, Jiajun Huang, Yuanxin Sun, Xing Gao, Changyun Fang

{"title":"Characteristics and clinical significance of tertiary lymphoid structures in OSCC.","authors":"Mianfeng Yao, Tianru Yang, Qiulan Li, Xinle Zhang, Ziran Zheng, Jiang Li, Jiajun Huang, Yuanxin Sun, Xing Gao, Changyun Fang","doi":"10.1111/odi.15080","DOIUrl":"10.1111/odi.15080","url":null,"abstract":"Objectives: This study aimed to investigate the characteristics of tertiary lymphoid structures (TLSs) in oral squamous cell carcinoma (OSCC) and their association with clinical and pathological features.Materials and methods: 12 TLS-related chemokines in TCGA database were analyzed to investigate the TLSs in OSCC. The density, maturity, and location of TLSs in a large cohort of 189 OSCC patients (114 of which had clinical and prognostic information) were assessed. And the significance between TLSs and clinicopathologic characteristics was analyzed.Results: Bioinformatics and analysis showed that TLSs were associated with better clinical outcomes in OSCC. Histological staining and analysis showed that the overall survival rate of the high-density group (71/112, 63.4%) was significantly higher (p < 0.0001) than that of the low-density group (41/112, 36.6%), and the high-density group had fewer lymph node metastases (50.0%/68.3%, p = 0.021). And TLSs were divided into 4 types according to the maturity and location. Different types of TLSs are associated with prognosis (OS, p < 0.0001), clinical features (T stage, p = 0.028; degree of differentiation, p = 0.043), and precancerous lesion types (OSF, p = 0.049) of OSCC patients.Conclusion: TLSs were closely associated with better OSCC prognosis, and a more systematic classification may better guide the formulation of further treatment options.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"387-400"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender Equality in Academic Indices of Oral Pathology/Medicine Researchers With CNPq Fellowship. 获得 CNPq 研究金的口腔病理学/医学研究人员学术指标中的性别平等。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-22 DOI: 10.1111/odi.15167

Árlen Almeida Duarte de Sousa, Daniella Reis Barbosa Martelli, Ricardo D Coletta, Eduardo A Oliveira, Hercílio Martelli Júnior

引用次数: 0