Oral diseases最新文献_第8页

Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits. 兔子髁突囊内骨折后椎间盘状态和髁突再生的变化

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-31 DOI: 10.1111/odi.15238

Siwei Xu, Kaixin Yan, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu

{"title":"Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits.","authors":"Siwei Xu, Kaixin Yan, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu","doi":"10.1111/odi.15238","DOIUrl":"10.1111/odi.15238","url":null,"abstract":"Background: The treatment procedure for intracapsular condylar fractures (ICF) is still being debated. The temporomandibular joint (TMJ) disc is a key factor for treating ICF. The study aims to investigate the changes in TMJ disc status and condylar cartilage regeneration following ICF in a rabbit model, to assist in planning treatment.Methods: Adolescent and adult rabbits received surgery on the left TMJs: (1) ICF with anterior disc displacement, (2) ICF with the removal of the ICF segment and disc. The animals were euthanized immediately, and at 4, 8, and 12 weeks after surgery. Their left TMJs were collected for histological, SOX 9 immunohistochemical, and micro-CT analyses.Results: All 36 TMJs (100%) showed anterior disc displacement at 4, 8, and 12 weeks after surgery. Also, condylar cartilage regeneration was observed in all 36 joints. Notably, partial regeneration of condylar cartilage was noted at 4 weeks after removal of the disc and ICF fractured segment in both adolescent and adult groups.Conclusion: Anterior displaced disc after ICF in adolescent and adult rabbits exhibited sustained disc displacement without therapeutic intervention. TMJ disc and associated attachment are crucial in the condylar cartilage regeneration after ICF.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1789-1799"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demystifying "Hyaline Angiopathy" of Pulse Granuloma in Oral and Extraoral Surgical Pathology. 在口腔及口外外科病理中对脉脉性肉芽肿“透明血管病变”的解释。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1111/odi.15287

Felipe Fornias Sperandio, Matheus de Castro Costa, Marina Lara de Carli, Rani Kanthan

{"title":"Demystifying \"Hyaline Angiopathy\" of Pulse Granuloma in Oral and Extraoral Surgical Pathology.","authors":"Felipe Fornias Sperandio, Matheus de Castro Costa, Marina Lara de Carli, Rani Kanthan","doi":"10.1111/odi.15287","DOIUrl":"10.1111/odi.15287","url":null,"abstract":"Background and objectives: Pulse granuloma (PG), or giant cell hyaline angiopathy, is an immune-mediated reaction often following the implantation of plant-derived food particles. PGs are primarily found in the oral cavity and gastrointestinal tract and may represent a histopathological pitfall, being mistaken for other granulomatous conditions or tumors. This study is the first to compare oral to extraoral PGs, aiming to clarify the \"hyaline angiopathy\" seen in PGs by developing a detailed histochemical and immunohistochemical profile of oral and colonic PGs.Methods: A computer search of 135,972 surgical pathology cases was conducted. PG histopathological slides, along with demographic and clinical data, were reviewed. Stains including Congo red, Masson trichrome, PAS, and immunostains CD31, ERG, and D2-40 were applied.Results: Sixteen cases (11 oral, 5 extraoral) were identified, ranging from 7 to 81 years of age. Oral PGs were linked to odontogenic cysts, while extraoral PGs were associated with intestinal inflammation and perforation. Angiolymphatic marker expression was limited to the inflamed connective tissue surrounding PG.Conclusions: Our findings suggest that PGs reflect a granulomatous response to edible components and support surgical excision. The absence of vascular markers indicates that the term \"angiopathy\" is misleading, proposing that these \"wormy\" structures are fibrocollagenous responses.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1816-1822"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis: Grade Modifiers Revisited. 牙周炎：分级调节剂再访。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-02-27 DOI: 10.1111/odi.15297

Obada Saleh, Anas Abdulmunim, Ibrahim Aboushakra, Maanas Shah, Abeer Hakam, Nabeel H M Alsabeeha, Momen A Atieh

{"title":"Periodontitis: Grade Modifiers Revisited.","authors":"Obada Saleh, Anas Abdulmunim, Ibrahim Aboushakra, Maanas Shah, Abeer Hakam, Nabeel H M Alsabeeha, Momen A Atieh","doi":"10.1111/odi.15297","DOIUrl":"10.1111/odi.15297","url":null,"abstract":"Objective: This review aimed to propose new grade modifiers for the risk assessment of periodontitis.Materials and methods: Literature on the known risk factors, current, and potential grade modifiers was reviewed.Results: The transition to a staging and grading system for periodontitis was driven by the need for consistent and comprehensive classification that facilitates diagnosis and personalized treatment planning. The new system assesses severity and complexity based on clinical attachment loss, radiographic bone loss, and patient history, and integrates risk factors into the grading scheme as grade modifiers. The two commonly used grade modifiers are smoking and diabetes mellitus. The changes to grade B or C are based on the number of cigarettes smoked per day and the level of glycemic levels, which are known thresholds used in association studies of risk factors for periodontitis. New grade modifiers such as systemic inflammatory response, rheumatoid arthritis, osteoporosis, obesity, and neurodegenerative disease were identified.Conclusion: While adding grade modifiers may increase complexity, they could improve the prognostic accuracy of the current classification, enabling more precise assessment, personalized treatment, and better management of periodontitis, especially in patients with systemic risk factors.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1637-1646"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma. 黏液表皮样癌的免疫结构模式及其潜在预后价值。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-09 DOI: 10.1111/odi.15216

Vy Ngoc Thuy Tran, Komkrit Ruangritchankul, Nikolaos G Nikitakis, Somponnat Sampattavanich, Joao N Ferreira, Risa Chaisuparat

{"title":"Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma.","authors":"Vy Ngoc Thuy Tran, Komkrit Ruangritchankul, Nikolaos G Nikitakis, Somponnat Sampattavanich, Joao N Ferreira, Risa Chaisuparat","doi":"10.1111/odi.15216","DOIUrl":"10.1111/odi.15216","url":null,"abstract":"Objectives: To define tumor immunoarchitectural patterns (IPs) and characterize the immune profile in salivary gland mucoepidermoid carcinoma (MEC) toward assessing MEC prognostic significance and implications for immunotherapy.Methods: This study analyzed 41 MEC cases, evaluating the tumor IPs and tumor-infiltrating lymphocyte (TIL) parameters by using whole-slide imaging and AI-assisted assessment. Immunohistochemistry of CD3 and CD8 markers was performed to assess key lymphocyte subpopulations.Results: Immune-rich (I-rich) tumors were characterized by high TIL density and were associated with aggressive tumor behavior, particularly in histological high-grade MEC, with a significant increase in TIL density observed in the inner invasive margin compartment (p < 0.05). I-rich tumor cases were linked to poorer disease-free survival (DFS) (Breslow = 4.686, p = 0.03). Aggressive MEC cases displayed a highly heterogeneous TIL profile, however, no TIL patterns showed a significant impact on DFS (p > 0.05).Conclusions: Despite the high immunogenicity suggested by the abundance of T lymphocytes, the protective role of CD8+ T lymphocytes was not prominent in MEC. I-rich tumors appeared more aggressive and unfavorable MEC cases exhibited high heterogeneity in their TIL profiles. Interrogating the role of TILs in the inner invasive tumor margin may offer a new mechanistic understanding for future immunotherapy discovery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1745-1756"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones. 微观结构和晶体组成：唾液腺结石的综合探索。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-02 DOI: 10.1111/odi.15234

Liu-Yang Qu, Dan-Ni Zheng, Xiao-Tong Ling, Guan-Qi Liu, Xiao-Yun Xu, Deng-Gao Liu

{"title":"Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones.","authors":"Liu-Yang Qu, Dan-Ni Zheng, Xiao-Tong Ling, Guan-Qi Liu, Xiao-Yun Xu, Deng-Gao Liu","doi":"10.1111/odi.15234","DOIUrl":"10.1111/odi.15234","url":null,"abstract":"Objective: To investigate the microarchitecture and crystalline composition of sialoliths and to explore their formation mechanisms.Methods: Sixty-six sialolith samples (51 from the submandibular glands and 15 from the parotid glands) were retrospectively collected. Their diameter and quality were measured. Micro-computed tomography, scanning electron microscopy, and polycrystalline X-ray diffractometer (XRD) were utilized to determine their microstructure and crystalline composition.Results: Stone diameter and weight averaged at 9.6 mm and 0.31 g, respectively. Submandibular stones showed larger size and weight than parotid stones. Microstructurally, the main stones were concentric (n = 51) or mixed (n = 15). Most concentric stones occurred at submandibular glands, while 80% of the mixed stones were parotid stones. Stone surface exhibited three microscopic structures: lamellar, grape-like, and porous, indicating their differences in mineralization process and composition. XRD revealed that all stones contained hydroxyapatite, with 57 containing whitlockite. Concentration of hydroxyapatite in concentric stones was significantly higher than that in mixed stones (p = 0.036) and correlated positively with stone diameter (p = 0.001). The microstructure and crystalline composition of multiple and recurrent stones were similar to that of single stones.Conclusion: Sialoliths display pronounced diversity in microarchitecture and crystalline composition, reflecting the differences in mineralization process and local microenvironments among stones.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1735-1744"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Recurrent Oral Ulcer on a Man's Tongue". 评论“男性舌部复发性口腔溃疡”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-10 DOI: 10.1111/odi.15257

Heitor Albergoni Silveira, Jorge Esquiche León

引用次数: 0

Clinical Characteristics and Prognostic Factors of 199 Salivary Acinic Cell Carcinoma. 199例唾液腺泡细胞癌的临床特点及预后因素分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1111/odi.15301

Lijing Zhu, Lisha Sun, Tie-Jun Li

{"title":"Clinical Characteristics and Prognostic Factors of 199 Salivary Acinic Cell Carcinoma.","authors":"Lijing Zhu, Lisha Sun, Tie-Jun Li","doi":"10.1111/odi.15301","DOIUrl":"10.1111/odi.15301","url":null,"abstract":"Objects: This retrospective study aimed to investigate the clinical characteristics and prognostic features of acinic cell carcinoma (AciCC) of the salivary gland.Methods: One Hundred Ninety-nine cases of AciCC were retrospectively reviewed. Clinical characteristics and outcomes were systematically collected. Recurrence-free survival, metastases-free survival, and overall survival of patients with different clinical variables were compared using the Kaplan-Meier method and Cox univariate regression.Results: A total of 199 patients were included (70 men, 129 women; mean age, 44.57 years). The parotid gland was most frequently affected (75.0%), and the majority of patients were asymptomatic (71.36%). Most patients underwent surgical treatment. Follow-up data were available for 155 patients, with a mean duration of 78.42 months. Local recurrence occurred in 11.6% of these patients, regional metastases in 6.5%, and distant metastases in 5.2%. Of the 10 patients with metastases, 4 died of AciCC. Poorer survival was significantly associated with age > 40 years, perineural invasion, neck dissection, and advanced stage (III/IV). Recurrence and metastases were strongly associated with AciCC-related mortality.Conclusions: Regular follow-up and careful lymph node assessment are critical for patients over 40 years, those with perineural invasion, advanced-stage disease, recurrence, or metastases, as these factors are linked to poorer outcomes in AciCCs.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1717-1725"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study. 探索口腔和肠道微生物群对溃疡性粘膜炎的影响：一项试点队列研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-06 DOI: 10.1111/odi.15246

Valentin Bartha, Sébastien Boutin, Dorothée L Schüßler, Anna Felten, Shila Fazeli, Florentina Kosely, Thomas Luft, Diana Wolff, Cornelia Frese, Kyrill Schoilew

{"title":"Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study.","authors":"Valentin Bartha, Sébastien Boutin, Dorothée L Schüßler, Anna Felten, Shila Fazeli, Florentina Kosely, Thomas Luft, Diana Wolff, Cornelia Frese, Kyrill Schoilew","doi":"10.1111/odi.15246","DOIUrl":"10.1111/odi.15246","url":null,"abstract":"Aim: Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT).Materials and methods: Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated.Results: Ten of 25 included patients developed ulcerations. The α-diversity decreased between T0 and T1, independent of ulcerations. PERMANOVA revealed differences in beta diversity between T1 stool samples from patients with and without ulcerations. At T1, saliva samples of patients with ulcerations showed an increase of Mycoplasma salvarius, while commensals decreased in saliva and mucosal swabs. The gut microbiome of both groups showed an overabundance of Enterococcus spp., associated with inflammatory conditions. Salival α-diversity of older and overweight patients decreased slower, whereas in mucosal swabs mucositis or impaired renal function was associated with a higher decline. Female gender and history of periodontitis were associated with increased stool microbiome changes, while self-reported probiotics intake was related to reduced changes.Conclusions: Ulcerations appeared in 40% of the patients. Distinct microbial changes, including increased abundance of Mycoplasma salivarius in saliva and decreased abundance of commensals, marked those with ulcerations.Trial registration: The study was registered in the German Register for Clinical Studies (DRKS00032882).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1776-1788"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Radiographs Findings Are Customary Abnomalies: Two Years Retrospective Study. 偶发x线片表现为习惯性异常：两年回顾性研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-13 DOI: 10.1111/odi.15222

Giselle Gadonski, Thiago Oliveira Gamba, Nádia Assein Arús, Pantelis Varvaki Rados

引用次数: 0

Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration. 达沙替尼和槲皮素减轻与年龄相关的牙槽骨炎症和中性粒细胞浸润。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-03-06 DOI: 10.1111/odi.15291

Jinru Tang, Jingya Li, Zeyu Hou, Rong He, Bingzhi Li, Jiajing Gong, Yuhang Xie, Wanrong Meng, Yunkun Liu, Takehito Ouchi, Longjiang Li, Bo Li

{"title":"Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.","authors":"Jinru Tang, Jingya Li, Zeyu Hou, Rong He, Bingzhi Li, Jiajing Gong, Yuhang Xie, Wanrong Meng, Yunkun Liu, Takehito Ouchi, Longjiang Li, Bo Li","doi":"10.1111/odi.15291","DOIUrl":"10.1111/odi.15291","url":null,"abstract":"Objective: Age-related alveolar bone resorption poses a major dental health challenge, yet its mechanisms and treatments are poorly understood. This study investigates the impact of dasatinib and quercetin (D + Q) treatment on senescent cells (SnCs), senescence-associated secretory phenotype (SASP), and neutrophil infiltration in aged alveolar bone, aiming to develop new strategies for combating age-related bone resorption.Methods: C57BL/6 mice (2 and 18 months) were used to examine alveolar bone resorption, inflammaging, and neutrophil infiltration. Aged mice received D + Q treatment to assess therapeutic effects. Key measurements included cementoenamel junction to the alveolar bone crest (CEJ-ABC) distance, periodontal ligament (PDL) thickness, osteometabolism markers, SnCs accumulation, SASP expression, and neutrophil infiltration.Results: Aged alveolar bone showed increased CEJ-ABC distance, atrophied periodontal ligament, and unbalanced osteometabolism, along with elevated SnCs, SASP, and neutrophils compared to young controls. D + Q treatment improved these conditions by reducing CEJ-ABC distance, enhancing periodontal ligament health, and boosting bone metabolism. It also lowered the expression of SnCs, SASP, and neutrophil markers.Conclusion: D + Q treatment effectively mitigates alveolar bone aging by clearing SnCs, lowering SASP levels, and reducing neutrophil aggregation, presenting a novel approach for age-related bone resorption.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1800-1815"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0