Oral diseases最新文献_第8页

Tumor-Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. 头颈部鳞状细胞癌的肿瘤-间质比例：系统回顾和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI: 10.1111/odi.15319

Gennaro Musella, Martina Coppini, Fábio França Vieira E Silva, Giuseppina Campisi, Mario Pérez-Sayáns, Vito Carlo Alberto Caponio, Alejandro I Lorenzo-Pouso

{"title":"Tumor-Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Gennaro Musella, Martina Coppini, Fábio França Vieira E Silva, Giuseppina Campisi, Mario Pérez-Sayáns, Vito Carlo Alberto Caponio, Alejandro I Lorenzo-Pouso","doi":"10.1111/odi.15319","DOIUrl":"10.1111/odi.15319","url":null,"abstract":"Background: Tumor-stroma ratio (TSR) has been recognized as a significant prognostic factor in various cancers. This systematic review evaluates the role of TSR in head and neck squamous cell carcinoma (HNSCC) and its association with patient outcomes such as overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and lymph node metastasis (LNM).Methods: A comprehensive search was conducted across Scopus, Embase, PubMed, and Web of Science. Nineteen studies were included. Data extraction and quality assessment were performed progressively, with meta-analyses. All studies assessed TSR using hematoxylin and eosin staining of tissue samples. The meta-analyses focused on the impact of TSR on OS, DFS, DSS, and LNM, providing pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding confidence intervals (CIs).Results: Meta-analysis revealed a significant association between TSR and OS (HR 1.99, 95% CI 1.71-2.32, p < 0.001), DFS (HR 2.07, 95% CI 1.80-2.39, p < 0.001), DSS (HR 2.33, 95% CI 1.95-2.78, p < 0.001), and LNM (OR 1.76, 95% CI 1.15-2.70, p = 0.01). Minimal to low heterogeneity was detected among studies, and no publication bias was observed.Conclusions: TSR can effectively identify high-risk patients, being a reliable prognostic marker that could be readily integrated into routine pathology practice for HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2382-2393"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to Treatment Initiation of Oral Cancer: Impact of a National Policy in Midwest Brazil. 口腔癌开始治疗的时间：巴西中西部国家政策的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-17 DOI: 10.1111/odi.15313

Mary Anne de Souza Alves França, Rejane Faria Ribeiro-Rotta, Nádia do Lago Costa, Patrícia Corrêa-Faria, Gabriela Moreira Policena, Maria do Carmo Matias Freire

引用次数: 0

Mucosal Wetness, Hyposalivation, and Local Defense in Periodontal Inflammation. 牙周炎症中的粘膜湿润、唾液分泌不足和局部防御。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-22 DOI: 10.1111/odi.15339

Buket Acar, Mehmet Özcan, Havanur Toz, Nagihan Koç, Barış Sarp Sevimli, Berke Berberoglu, Ayşe Buruş, Erdem Karabulut, Yasemin Bayazıt, Nermin Tarhan

{"title":"Mucosal Wetness, Hyposalivation, and Local Defense in Periodontal Inflammation.","authors":"Buket Acar, Mehmet Özcan, Havanur Toz, Nagihan Koç, Barış Sarp Sevimli, Berke Berberoglu, Ayşe Buruş, Erdem Karabulut, Yasemin Bayazıt, Nermin Tarhan","doi":"10.1111/odi.15339","DOIUrl":"10.1111/odi.15339","url":null,"abstract":"Objective: To evaluate the potential relationship between local salivary coating of mucosal surfaces, clinical periodontal status, hyposalivation, and local inflammatory response with a specific reference for MUC4 and TNF-α levels.Materials and methods: Based on their salivary flow rates, 24 hyposalivators and 26 normosalivators were recruited. Mucosal wetness (MW) and mucosal surface pH values were determined. Clinical periodontal parameters were recorded and gingival crevicular fluid (GCF) samples were obtained. Mucin 4 (MUC4) and TNF-α levels in local and whole salivary and GCF samples were determined with ELISA kits.Results: GI and BoP were significantly higher in the hyposalivation group, while MW and mucosal pH values were significantly lower in hyposalivators, except for the labial surface. MUC4 and TNF-α levels showed significant differences among the groups. In the anterior region, GCF TNF-α concentration was high in hyposalivation patients; in the molar region, GCF MUC4 was significantly higher in normosalivators.Conclusions: Based on the differences which MW presented at local sites, MW may be utilized as a possible practical tool to reveal the local salivary characteristics in various clinical periodontal conditions based on the presence/extent of local inflammatory response, which may be important when the site-specific nature of periodontal diseases is concerned.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2551-2563"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NUTF2 Promotes Proliferation of Oral Squamous Cell Carcinoma Through PI3K/AKT Signaling Pathway. NUTF2通过PI3K/AKT信号通路促进口腔鳞状细胞癌增殖

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-06-22 DOI: 10.1111/odi.15326

Zhihong Chen, Zhenyuan Zhao, Teng Xu, Feng Zou, Yuemei Yang, Peng Lu, Yiren Chen, Zaiou Zhu, Yao He, Yunong Wu, Xu Ding, Xiaomeng Song

{"title":"NUTF2 Promotes Proliferation of Oral Squamous Cell Carcinoma Through PI3K/AKT Signaling Pathway.","authors":"Zhihong Chen, Zhenyuan Zhao, Teng Xu, Feng Zou, Yuemei Yang, Peng Lu, Yiren Chen, Zaiou Zhu, Yao He, Yunong Wu, Xu Ding, Xiaomeng Song","doi":"10.1111/odi.15326","DOIUrl":"10.1111/odi.15326","url":null,"abstract":"Background: Oral squamous cell carcinoma (OSCC) is associated with a poor prognosis. Nuclear transport factor 2 (NUTF2) participates in nucleoprotein transport. However, the mechanism of NUTF2 in OSCC remains unclear.Methods: We conducted a retrospective study in which patients had not received preoperative chemoradiotherapy and all oral lesions were primary. We assessed the NUTF2 expression in OSCC patients' tissues by polymerase chain reaction and western blot. Immunohistochemical staining was performed based on 203 OSCC specimens to analyze the characteristics of NUTF2 expression. Furthermore, we studied the impact of NUTF2 on OSCC cells through a CCK-8, wound healing, transwell, and flow cytometry assays. The mechanism of NUTF2 was further investigated through western blot. The effect of NUTF2 on tumor growth was confirmed in vivo.Results: NUTF2 was upregulated in OSCC tissues and related to the poor prognosis. The overexpression of NUTF2 promoted OSCC cell growth in CCK-8 and wound healing. Moreover, our results indicated that the AKT signaling pathway mediated the promoting role of NUTF2 in OSCC. These results were verified in subcutaneous neoplasia in vivo.Conclusion: Our study highlights the promoting effect of NUTF2 on OSCC proliferation and suggests its potential as a therapeutic target for molecular therapy of OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2441-2455"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the Adoption of Terminology for Oral Potentially Malignant Disorders. 采用口腔潜在恶性疾病术语的趋势。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-31 DOI: 10.1111/odi.15332

Brunno Santos de Freitas Silva, Lucila Valadão Sant'ana Tertuliano Trovão, Eleazar Mezaiko, Tiago Paiva Prudente, Reuber Mendes Rocha, Alan Roger Santos-Silva, Saman Warnakulasuriya, Fernanda Paula Yamamoto-Silva

引用次数: 0

P. gingivalis OMVs Attenuate the Osteogenesis of PDLSCs by Activating PERK Signaling. 牙龈卟啉卟啉omv通过激活PERK信号减弱PDLSCs的成骨作用。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1111/odi.15320

Yingying Huang, Xiaoning He, Jiangwei Liao, Dihao Tao, Hanzhe Wang, Bei Li, Zhiwei Dong, Junjie Wu

{"title":"P. gingivalis OMVs Attenuate the Osteogenesis of PDLSCs by Activating PERK Signaling.","authors":"Yingying Huang, Xiaoning He, Jiangwei Liao, Dihao Tao, Hanzhe Wang, Bei Li, Zhiwei Dong, Junjie Wu","doi":"10.1111/odi.15320","DOIUrl":"10.1111/odi.15320","url":null,"abstract":"Objective: The Porphyromonas gingivalis outer membrane vesicles (P. gingivalis OMVs) carry toxins that contribute to the onset and progression of periodontitis. These OMVs have been implicated in host cell invasion and damage. This study aimed to determine the role and potential mechanisms of P. gingivalis OMVs on periodontal inflammation.Methods: A model of PDLSCs induced by P. gingivalis OMVs was developed, and changes in their biological functions were examined. We established a rat periodontitis model to confirm whether P. gingivalis OMV promotes the periodontal inflammatory phenotype. Additionally, the potential mechanisms by which P. gingivalis OMVs impair the osteogenic differentiation capacity of PDLSCs were investigated.Results: P. gingivalis OMVs inhibited the proliferation, promoted apoptosis and suppressed the osteogenesis of PDLSCs, while promoting periodontal inflammatory phenotype in vivo. Furthermore, mechanistic studies revealed that pretreatment of PDLSCs with 4-phenylbutyric acid (4-PBA) prevented the P. gingivalis OMVs-induced activation of the PERK pathway and restored the osteogenesis of PDLSCs.Conclusions: We demonstrate that P. gingivalis OMV exacerbates the periodontitis phenotype and inhibits the regenerative function of PDLSCs, potentially through mechanisms involving endoplasmic reticulum dysfunction.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2518-2530"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMURF1 Regulates Periodontal Stem Cell Injury and Osteogenic Differentiation by Regulating TRAF4. SMURF1通过调节TRAF4调控牙周干细胞损伤和成骨分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1111/odi.15341

Ziming Wei, Hui Xiao, Lishu Zhou, Yarong Wang

{"title":"SMURF1 Regulates Periodontal Stem Cell Injury and Osteogenic Differentiation by Regulating TRAF4.","authors":"Ziming Wei, Hui Xiao, Lishu Zhou, Yarong Wang","doi":"10.1111/odi.15341","DOIUrl":"10.1111/odi.15341","url":null,"abstract":"Objective: This study aimed to investigate the specific role and mechanistic actions of tumor necrosis factor receptor-associated factor 4 (TRAF4) in periodontitis.Methods: Human periodontal ligament stem cells (PDLSCs) were exposed to lipopolysaccharide (LPS). Then, real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting (WB) were carried out to determine the mRNA and protein expression levels of Smad ubiquitination regulator 1 (SMURF1). The relationship between TRAF4 and SMURF1, as predicted by the STRING and GeneMANIA databases, was verified by co-immunoprecipitation (Co-IP). Finally, both TRAF4 and SMURF1 were inhibited in PDLSCs by cell transfection, and the regulatory mechanisms involved were investigated by cell counting kit-8 assays, enzyme linked immunosorbent assay, WB, alkaline phosphatase, and alizarin red staining.Results: The gene and protein expression levels of SMURF1 in PDLSCs increased following LPS induction (p < 0.001); cell viability was decreased (p < 0.001), TRAF4 expression was decreased (p < 0.001), and cell-mineralized nodules were inhibited. Inhibition of SMURF1 expression increased PDLSCs activity and TRAF4 expression levels (p < 0.001), increased the number of cell-mineralized nodules, and enhanced cellular osteogenic capacity (p < 0.001).Conclusions: SMURF1 regulates LPS-stimulated injury and improves the capacity for osteogenic differentiation in PDLSCs by downregulating the expression of TRAF4.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2572-2583"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Non-Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis. 非手术治疗对III/IV期C级牙周炎血液学指标的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI: 10.1111/odi.15340

Xiaoyuan Guan, Xian-E Wang, Yi Li, Jingling Xu, Xinran Xu, Lu He, Li Xu, Huanxin Meng, Ruifang Lu

{"title":"Effects of Non-Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis.","authors":"Xiaoyuan Guan, Xian-E Wang, Yi Li, Jingling Xu, Xinran Xu, Lu He, Li Xu, Huanxin Meng, Ruifang Lu","doi":"10.1111/odi.15340","DOIUrl":"10.1111/odi.15340","url":null,"abstract":"Objective: To investigate the short-term effects of non-surgical periodontal treatment (NSPT) on clinical and hematological indices in stage III/IV grade C periodontitis patients.Methods: A total of 121 systemically healthy patients with generalized stage III/IV, grade C periodontitis were enrolled. Clinical indices (plaque index, probing depth, bleeding index, attachment loss) and hematological biomarkers [white blood cell count (WBC), mean platelet volume (MPV), neutrophil count (NEUT), neutrophil percentage (NEUT%), lymphocyte percentage (LYM%)] were measured before and 6-8 weeks after NSPT. Patients were divided into younger (≤ 35 years) and elder (> 35 years) groups, further stratified by systemic antibiotics usage. Analyses were performed using chi-squared tests, paired t-tests, and Pearson's correlation.Results: NSPT resulted in clinical indices improvement, as well as a reduction in WBC, NEUT, NEUT%, and an increase in MPV and LYM% in both groups. SRP-with-antibiotics subgroups showed more significant changes. SRP-without-antibiotics subgroups showed six significant correlations in both groups (p < 0.05); SRP-with-antibiotics subgroups showed 11 correlations in the younger and five in the elder group (p < 0.05).Conclusions: NSPT improved clinical and hematological outcomes in stage III/IV grade C periodontitis patients over 6-8 weeks. Younger patients exhibited more significant changes than elder patients, especially in the SRP-without-antibiotics subgroup.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2608-2618"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical Validation of Unsupervised Clustering for Adolescent TMD: A Cross-Sectional Study. 青少年TMD的无监督聚类的统计验证：一项横断面研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1111/odi.15331

Hye Kyoung Kim

{"title":"Statistical Validation of Unsupervised Clustering for Adolescent TMD: A Cross-Sectional Study.","authors":"Hye Kyoung Kim","doi":"10.1111/odi.15331","DOIUrl":"10.1111/odi.15331","url":null,"abstract":"Objective: This study employs unsupervised clustering to identify Temporomandibular disorders (TMD) phenotypes in adolescents, aiming to identify distinct clusters based on biopsychosocial features. It compares these clusters with conventional TMD classifications to assess if this method offers enhanced insights into TMD diagnosis.Methods: Data from 662 adolescent patients with TMD were analyzed using unsupervised clustering and classified into four groups based on DC/TMD Axis I: 1 (disc displacement), 2 (joint pain), 3 (muscle pain), and 4 (combined joint and muscle pain). Patient-reported outcomes were measured with instruments including the Brief Pain Inventory, the Pain Catastrophizing Scale, the Symptom Checklist-90-Revised, and the Pittsburgh Sleep Quality Index. Statistical analyses validated the clusters against conventional classifications.Results: Three distinct clusters were identified: High Impact (n = 70), Mild Symptoms (n = 423), and High Catastrophizing (n = 169), each displaying unique patterns in pain severity, pain catastrophizing, psychological distress, and sleep disturbances. Multinomial logistic regression of conventional TMD classifications revealed that only pain severity significantly differentiated the subcategories among these biopsychosocial factors.Conclusions: The findings underscore the variability in TMD presentations among adolescents and suggest that integrating phenotyping into the conventional diagnostic approach could significantly improve diagnostic accuracy and treatment outcomes, facilitating better management of high-risk adolescent patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2596-2607"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transgender Individuals in the Eyes of Dental Professionals: A Data-Driven Study. 牙科专业人员眼中的变性人：一项数据驱动的研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1111/odi.15310

Büşra Yılmaz, Hüseyin Sagman, Timur Köse, Gülnur Emingil

{"title":"Transgender Individuals in the Eyes of Dental Professionals: A Data-Driven Study.","authors":"Büşra Yılmaz, Hüseyin Sagman, Timur Köse, Gülnur Emingil","doi":"10.1111/odi.15310","DOIUrl":"10.1111/odi.15310","url":null,"abstract":"Objectives: Transgender individuals continue to face discrimination, particularly in accessing oral healthcare. This study aimed to evaluate dentists' attitudes toward transgender people and their knowledge of gender-affirming care.Materials and methods: A questionnaire assessing demographic data, clinical approaches, and knowledge of gender-affirming care was distributed via social media, professional chambers, and associations. Descriptive statistics were analyzed using SPSS, with Chi-square and Fisher exact tests, alongside logistic regression for appropriate questions.Results: A total of 403 dentists participated, with 8% reporting professional prejudices against transgender individuals. Dentists who associated transgender patients with increased clinical infection rates were statistically more likely to hold prejudices (p < 0.05). Additionally, 60.2% expressed interest in training to enhance communication with transgender patients. Female dentists were significantly more likely to be open to such training (p < 0.05).Conclusion: The findings highlight a strong desire among dentists for training to improve communication with transgender patients, along with a lack of knowledge about key topics such as gender-affirming, endogenous hormones, and their oral health implications. This underscores the need for targeted educational initiatives in the dental community.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2652-2660"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0