Oral diseases最新文献_第8页

Oral Dysbiosis and Malignant Transformation of Oral Potentially Malignant Disorders: The Missing LPS-VEGF Link. 口腔生态失调和口腔潜在恶性疾病的恶性转化：缺失的LPS-VEGF联系。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70487

Lucas Alves da Mota Santana, Michelly Kierkigard Campos de Oliveira, Carlos Eduardo Palanch Repeke, Lysandro Pinto Borges, Wilton Mitsunari Takeshita, Gina Délia Roque-Torres

引用次数: 0

Hormone Replacement Therapy and Periodontitis in Postmenopausal Women: An Updated Systematic Review. 激素替代疗法和绝经后妇女牙周炎：最新的系统综述。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70463

Shahen Hiwa Omer, Mohammed Khalid Mahmood, Yad Mariwan Mohammed Amin, Florence Carrouel, Romain Lan

引用次数: 0

A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma. 脂质代谢相关基因标记对头颈部鳞状细胞癌的预后分层并反映代谢-免疫异质性。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70482

Ting-Zhi Xie, Xin-Yi Sun, Jing Wang, Zhi Wang, Ning Du, Xi-Yuan Ge

{"title":"A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma.","authors":"Ting-Zhi Xie, Xin-Yi Sun, Jing Wang, Zhi Wang, Ning Du, Xi-Yuan Ge","doi":"10.1111/odi.70482","DOIUrl":"https://doi.org/10.1111/odi.70482","url":null,"abstract":"Objective: Lipid metabolism-related genes (LMRGs) are crucial in head and neck squamous cell carcinoma (HNSCC) progression. This study aimed to construct and validate a prognostic model for HNSCC based on LMRGs.Methods: Prognostic LMRGs were screened by analyzing RNA sequencing and clinical data from TCGA and GEO databases, and a prognostic model was constructed. Patients were divided into high- and low-risk groups according to the risk score. Further enrichment analysis, tumor microenvironment (TME) analysis, drug sensitivity analysis, and in vitro validation were performed.Results: Eleven LMRGs (PER2, CTLA4, EPHX3, ABCB1, ANO1, TRIB3, PTX3, OLR1, DKK1, FABP4, and CDKN2A) were identified. Patients in the high-risk group had worse survival, and the risk score was an independent prognostic factor. A nomogram combining risk score and clinical characteristics accurately predicted survival. TME analysis revealed immune dysregulation in the high-risk group. Drug sensitivity analysis showed that the high-risk group was more sensitive to lovastatin. In vitro, lovastatin suppressed malignant behaviors and induced a transcriptomic shift toward a low-risk signature.Conclusion: The results validate the biological significance of the model, highlight potential associations between lipid metabolism and the immune microenvironment in HNSCC, and provide a theoretical basis for further investigating metabolism-related therapeutic strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are We Asking About Tirzepatide? Emerging Oral Health Implications for Oral Medicine Practice. 我们问的是替西帕肽吗？口腔医学实践对口腔健康的影响。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70484

Diogo de Azevedo Miranda, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade

引用次数: 0

Atopic Dermatitis and Periodontitis: Emerging Population-Based Data. 特应性皮炎和牙周炎：新兴的基于人群的数据。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-02 DOI: 10.1111/odi.70474

Mohammed Taib Fatih, Mohammed Khalid Mahmood, Yad Mariwan Mohammed Amin, Florence Carrouel, Romain Lan

引用次数: 0

Intratumoral Administration of Recombinant Murine Interleukin-12 Prevents Tumor Progression and Bone Invasion. 肿瘤内给药重组小鼠白细胞介素-12阻止肿瘤进展和骨侵袭。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-02 DOI: 10.1111/odi.70399

Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi

{"title":"Intratumoral Administration of Recombinant Murine Interleukin-12 Prevents Tumor Progression and Bone Invasion.","authors":"Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi","doi":"10.1111/odi.70399","DOIUrl":"https://doi.org/10.1111/odi.70399","url":null,"abstract":"Objective: Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin-12 (IL-12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion.Methods: The effects of IL-12 on tumor growth and bone resorption were evaluated using subcutaneous and bone invasion models of OSCC in both immunocompetent and athymic mice. Bone resorption was assessed by micro-computed tomography (CT). In addition, quantitative polymerase chain reaction (qPCR) was performed to quantify the expression of osteoclast markers (Acp5, Ctsk) and immune-related genes (Ifng, Fasl).Results: Intratumoral injection of recombinant murine IL-12 (r-mIL-12) significantly prolonged mouse survival and suppressed tumor growth in immunocompetent mice. Micro-CT revealed reduced bone resorption in the r-mIL-12-treated group. Consistently, qPCR demonstrated downregulation of Acp5 and Ctsk, along with upregulation of Ifng and Fasl compared to controls. In contrast, r-mIL-12 treatment had no significant effect on tumor growth or bone resorption in athymic mice, underscoring the importance of T cells in controlling bone invasion.Conclusions: These findings suggest that local administration of r-mIL-12 may serve as an effective therapeutic approach for OSCC with mandibular bone invasion.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Medicine Under Review: Current Practices and Future Pathways for Specialty Recognition. 口腔医学回顾：目前的实践和未来的专业认可途径。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-31 DOI: 10.1111/odi.70382

N G Nikitakis, M Georgaki, E Piperi, A Vissink, I Alajbeg, I von Bültzingslöwen, B Carey, S Kantola, A R Kerr, N Yarom, M Carrozzo, M Escudier, M D Mignogna, M Meleti, K Delli

引用次数: 0

AQP1 Corrects Acinar Cells' Secretion Deficits in Sjögren's Disease. AQP1纠正Sjögren病中腺泡细胞分泌缺陷

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-30 DOI: 10.1111/odi.70179

Paola Perez, Blake M Warner, Youngmi Ji, Sandra Afione, Thomas J F Pranzatelli, Margaret E Beach, Zohreh Khavandgar, Margie Grisius, Eileen Pelayo, Daniel Martin, Alan N Baer, John A Chiorini

{"title":"AQP1 Corrects Acinar Cells' Secretion Deficits in Sjögren's Disease.","authors":"Paola Perez, Blake M Warner, Youngmi Ji, Sandra Afione, Thomas J F Pranzatelli, Margaret E Beach, Zohreh Khavandgar, Margie Grisius, Eileen Pelayo, Daniel Martin, Alan N Baer, John A Chiorini","doi":"10.1111/odi.70179","DOIUrl":"https://doi.org/10.1111/odi.70179","url":null,"abstract":"Introduction: Sjögren's disease (SjD) is a systemic autoimmune disease characterized by dry mouth, dry eyes, and profound fatigue. Preclinical studies suggest that AQP1 gene expression in salivary glands corrects salivary hypofunction in preclinical and clinical studies of radiation-induced xerostomia and improves salivary and lacrimal function in SjD mouse models.Subjects and methods: To evaluate its therapeutic potential, we tested AQP1 gene therapy using labial salivary gland (LSG) biopsies from patients with SjD, non-SjD, and healthy volunteer glands (HV).Results: Ex vivo cultures of LSG lobules were viable, responsive to stimulation, and transducible with an AAV2 vector encoding AQP1. AQP1 expression increased fluid secretion in most samples, with recovery reaching up to 80% of healthy volunteer levels. Baseline transcriptomic analysis identifies 94 genes that correlated with treatment response, with inflammatory and epithelial signature correlating with success and fibrotic signatures with non-response. Histological evaluation confirmed greater fibrosis in non-responding samples. Thus, treatment effects were functionally significant but transcriptionally minimal indicating targeted therapeutic action without altering homeostatic transcription.Conclusion: These findings demonstrate that AAV2-AQP1 expression enhances fluid secretion in human LSGs and highlight fibrosis-associated loss of glandular parenchyma as a major barrier to therapeutic efficacy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menopause, Neurodegeneration and Burning Mouth Syndrome: A Hypothesis-Generating Perspective. 更年期，神经退行性变和灼口综合征：一个假设生成的观点。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-24 DOI: 10.1111/odi.70479

Alan Roger Santos-Silva, Satu K Jääskeläinen, Thaís Cristina Esteves-Pereira, Ana Carolina Prado-Ribeiro

引用次数: 0

scRNA-Seq Links CD8 Effector T Cells to Periodontitis via Transcriptional Reprogramming and Enhanced PARs Signaling. scRNA-Seq通过转录重编程和增强PARs信号将CD8效应T细胞与牙周炎联系起来。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-24 DOI: 10.1111/odi.70423

Fukai Ren, Xiqian Liu, Bin Yan

{"title":"scRNA-Seq Links CD8 Effector T Cells to Periodontitis via Transcriptional Reprogramming and Enhanced PARs Signaling.","authors":"Fukai Ren, Xiqian Liu, Bin Yan","doi":"10.1111/odi.70423","DOIUrl":"https://doi.org/10.1111/odi.70423","url":null,"abstract":"Background: Periodontitis (PD) is a chronic inflammatory disease characterized by dysregulated immune responses and periodontal tissue destruction. While T lymphocytes are implicated in PD pathogenesis, the roles of specific T cell subsets remain unclear.Methods: We analyzed single-cell RNA sequencing data from periodontal tissues of 5 PD patients and 4 healthy controls (GSE171213). Cell types were annotated using Seurat, and differential expression, transcription factor networks (SCENIC), and cell-cell communication (CellChat) were analyzed to investigate T cell heterogeneity.Results: Thirteen cell types were identified, with a significant reduction in overall T cell proportion in PD. Among T cell subsets, the proportion of CD8 effector T cells was increased in PD patients and exhibited activation of cytotoxic and related inflammatory pathways. Key transcription factors ETV1 and GABPA were upregulated in these CD8 effector T cells from PD patients, regulating target genes including CCL4 and CCL4L2. Cell-cell communication analysis revealed enhanced PARs signaling in PD, mediated by GZMA-F2R and GZMA-PARD3 pairs from CD8 effector T cells to fibroblasts, pericytes, and endothelial cells.Conclusion: Our study suggests that CD8 effector T cells may contribute to PD pathogenesis, potentially through transcriptional reprogramming and amplified PARs signaling, offering new insights into immunopathology and potential therapeutic targets.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0