Oral diseases最新文献

Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study. 子宫内膜异位症相关牙周病：一项大型队列研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-26 DOI: 10.1111/odi.70044

Maria Teresa Agneta, Giuseppe D'Albis, Letizia Lorusso, Nicola Bartolomeo, Antonia Abbinante, Anna Antonacci, Pietro Signorile, Francesco D'Aiuto, Elisa Mazza, Massimo Corsalini, Saverio Capodiferro

{"title":"Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study.","authors":"Maria Teresa Agneta, Giuseppe D'Albis, Letizia Lorusso, Nicola Bartolomeo, Antonia Abbinante, Anna Antonacci, Pietro Signorile, Francesco D'Aiuto, Elisa Mazza, Massimo Corsalini, Saverio Capodiferro","doi":"10.1111/odi.70044","DOIUrl":"https://doi.org/10.1111/odi.70044","url":null,"abstract":"Objective: Endometriosis is a chronic estrogen-dependent gynecological disease affecting millions of women worldwide. Besides its well-established impact on reproductive health, emerging evidence suggests a potential association between endometriosis and periodontal disease. The present study discusses the interplay between the two diseases, exploring shared immunopathological mechanisms, including chronic inflammation, hormonal imbalance, and immune system modulation.Materials and methods: A 45-question standardized questionnaire was answered by 4072 women clinically diagnosed with endometriosis to identify self-reported periodontal status, oral hygiene habits, and systemic symptoms.Results: Findings report that more severe stages of endometriosis are related to increased awareness of periodontal disease, greater gingival bleeding, xerostomia, and mucosal alterations. Moreover, greater diagnostic latency aggravates both systemic and oral disorders, supporting the necessity of early treatment. These findings highlight the need for a single, multidisciplinary standard of patient care involving gynecologists, dentists, dental hygienists, and other healthcare providers.Conclusion: By connecting gynecological and dental care, this study aims to promote awareness, facilitate early diagnosis, and improve quality of life for women suffering from endometriosis. Future research must explore mechanisms linking the conditions and assess therapeutic approaches to alleviate oral health issues in these individuals.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA FENDRR Inhibits Mitochondrial Apoptosis via TET2-Mediated DNA Demethylation of MFN1 in NSCPO. LncRNA FENDRR通过tet2介导的MFN1 DNA去甲基化抑制NSCPO中线粒体凋亡。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-26 DOI: 10.1111/odi.70035

Caihong Wu, Haojie Liu, Zerui Shan, Yu Xia, Panpan Zhao, Zhongyin Zhang, Gu Yueguang, Junqing Ma

{"title":"LncRNA FENDRR Inhibits Mitochondrial Apoptosis via TET2-Mediated DNA Demethylation of MFN1 in NSCPO.","authors":"Caihong Wu, Haojie Liu, Zerui Shan, Yu Xia, Panpan Zhao, Zhongyin Zhang, Gu Yueguang, Junqing Ma","doi":"10.1111/odi.70035","DOIUrl":"https://doi.org/10.1111/odi.70035","url":null,"abstract":"Background: Non-syndromic cleft palate only (NSCPO) and non-syndromic cleft lip with or without cleft palate (NSCL/P) are distinct malformations with different or partially overlapping etiologies. While NSCL/P has been extensively studied, NSCPO remains relatively understudied. Emerging evidence suggests that long noncoding RNAs (lncRNAs) contribute to craniofacial development, potentially by regulating apoptosis.Methods: This study investigated the role of FENDRR, a lncRNA previously found to be downregulated in NSCL/P, in NSCPO pathogenesis. FENDRR expression in NSCPO tissues was analyzed via RT-qPCR and fluorescence in situ hybridization. Apoptosis in human embryonic palatal mesenchymal (HEPM) cells was assessed using Western blotting, flow cytometry, and TUNEL assays. Bioinformatics, methylation-specific PCR, dual-luciferase reporter assays, and RNA immunoprecipitation were employed to examine FENDRR's interaction with MFN1.Results: FENDRR was significantly reduced in NSCPO tissues. FENDRR knockdown disrupted mitochondrial dynamics and activated mitochondrial apoptosis in HEPM cells. Mechanistically, FENDRR formed an RNA-DNA triplex with the MFN1 promoter, recruiting TET2 to promote MFN1 transcription via promoter demethylation.Conclusions: FENDRR enhances MFN1 expression, maintains mitochondrial fusion, and suppresses apoptosis in HEPM cells. This study provides novel insights into the regulatory role of lncRNAs in NSCPO pathogenesis and identifies FENDRR as a potential therapeutic target.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Lymphocyte Infiltration Shapes Corticosteroid Efficacy in Oral Lichen Planus. 不同淋巴细胞浸润影响皮质类固醇治疗口腔扁平苔藓的疗效。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70038

Yiwen Deng, Yufeng Wang, Junjun Chen, Guanhuan Du, Hui Yao, Lei Pan, Ting Gu, Sven Eric Niklander, Zhen Tian, Guoyao Tang

{"title":"Differential Lymphocyte Infiltration Shapes Corticosteroid Efficacy in Oral Lichen Planus.","authors":"Yiwen Deng, Yufeng Wang, Junjun Chen, Guanhuan Du, Hui Yao, Lei Pan, Ting Gu, Sven Eric Niklander, Zhen Tian, Guoyao Tang","doi":"10.1111/odi.70038","DOIUrl":"https://doi.org/10.1111/odi.70038","url":null,"abstract":"Background: Oral lichen planus (OLP) is a chronic, immune-mediated disorder affecting 2%-4% of the population. Corticosteroids are commonly used for treatment, but responses vary, likely due to differences in lymphocyte profiles. This study evaluated the impact of CD20+ B cells and CD38+ plasma cells on corticosteroid efficacy in OLP patients.Patients and methods: This retrospective study included 101 patients with symptomatic, diffuse, and severe OLP. Immunohistochemical staining identified CD3+ T cells, CD20+ B cells, and CD38+ plasma cells in tissue lesions. All patients received prednisone, and outcomes were assessed using Reticulation/Erosion/Ulceration (REU) and Visual Analog Scale (VAS) scores. Statistical analyses compared treatment responses based on lymphocyte profiles.Results: All patients showed CD3-positive T cell infiltration. Patients in the CD20- group showed significantly greater reductions in REU and VAS scores than the CD20+ group, indicating that B cell infiltration may reduce corticosteroid efficacy. Conversely, CD38+ patients exhibited greater score reductions than CD38- patients, suggesting that plasma cells may enhance responsiveness to treatment. The CD38+/CD20- group exhibited the most favorable response; the CD38-/CD20+ group had the least.Conclusions: Infiltration by B cells and plasma cells influences corticosteroid response in OLP. B cells are associated with reduced efficacy, while plasma cells correlate with improved treatment outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hard Nodule on the Posterior Portion of the Tongue in a Young Patient. 一个年轻病人舌后部的硬结节。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70039

Jing Xu, Ying Wan, Jiangning Luo, Hanwen Chu

引用次数: 0

Speech and Swallowing Disorders in Adolescent and Young Adults With Oral Cavity Cancer. 青少年和青年口腔癌患者的语言和吞咽障碍

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70041

Wei Deng, Guiyi Zhao, Yudong Xiao, Kaixin Guo, Sien Zhang, Guiqing Liao, Le Yang, Yujie Liang

{"title":"Speech and Swallowing Disorders in Adolescent and Young Adults With Oral Cavity Cancer.","authors":"Wei Deng, Guiyi Zhao, Yudong Xiao, Kaixin Guo, Sien Zhang, Guiqing Liao, Le Yang, Yujie Liang","doi":"10.1111/odi.70041","DOIUrl":"https://doi.org/10.1111/odi.70041","url":null,"abstract":"Objective: To evaluate the speech and swallowing function and recovery status in adolescent and young adult (AYAs) patients with oral cavity cancer (OCC).Methods: A cohort study was conducted in AYAs patients with OCC from August 2019 to April 2021. The swallowing and speech functions were evaluated by M.D. Anderson dysphagia inventory (MDADI), 10-item eating assessment tool (EAT-10) and speech handicap index (SHI) at pretreatment and postoperative stages. Multiple linear regression and linear mixed models were employed.Results: A total of 661 patients were enrolled, including 143 AYAs and 518 individuals aged ≥ 40. The preoperative total scores of MDADI, EAT-10, and SHI were worse in AYAs patients. AYAs patients with advanced T stage (T3-T4) before surgery exhibited worse scores for MDADI, EAT-10, and SHI. All patients presented the poorest outcomes within the initial 3 months postoperatively. However, a more rapid recovery trend of swallowing and speech function was demonstrated in the AYAs. Adjuvant radiotherapy/chemotherapy, advanced T stage (T3-T4), tracheostomy, or flap reconstruction were key risk factors of impairing speech and swallowing functions in AYAs patients.Conclusions: AYAs experience worse speech and swallowing function in the pretreatment stage and generally exhibit a higher potential for recovery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD. 从发育不良到癌：真皮因子、基质酶和胰蛋白酶在OPMD中的表达模式。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-24 DOI: 10.1111/odi.70043

Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Carol Kobori da Fonseca, Pedro Franco Ferreira, Leandro Dorigan de Macedo, Graziela Cavalcanti, Luiz Carlos Conti de Freitas, Ana Carolina Fragoso Motta, Alan Grupioni Lourenço, Katiuchia Uzzun Sales

{"title":"From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD.","authors":"Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Carol Kobori da Fonseca, Pedro Franco Ferreira, Leandro Dorigan de Macedo, Graziela Cavalcanti, Luiz Carlos Conti de Freitas, Ana Carolina Fragoso Motta, Alan Grupioni Lourenço, Katiuchia Uzzun Sales","doi":"10.1111/odi.70043","DOIUrl":"https://doi.org/10.1111/odi.70043","url":null,"abstract":"Background: The malignant transformation of oral potentially malignant disorders (OPMDs) lacks reliable molecular markers. Dermokine and matriptase are involved in epithelial differentiation and inflammation, while tryptase is associated with the tumor microenvironment, which may contribute to carcinogenesis. This study investigated these molecules as potential biomarkers for predicting the malignant progression of OPMDs.Methods: This was a cross-sectional comparative study. Paired normal oral mucosa (NM) and OPMD tissues (n = 21) were assessed, while oral and oropharyngeal squamous cell carcinoma (OOSCC) samples (n = 64) were evaluated using tissue microarrays. Proteomic analysis of five OPMD cases identified dermokine, tryptase, and matriptase as potential biomarkers, further examined through clinical, histopathological, and immunohistochemical analyses across NM, OPMD, and OOSCC tissues.Results: Females comprised 52% of the OPMD group, whereas males accounted for 87.5% of OOSCC cases. Dermokine, tryptase, and matriptase showed higher expression in OPMD and OOSCC than NM. Dermokine was predominantly observed in OPMD, well-differentiated OOSCC, and NM from patients who progressed to malignancy (p = 0.019). Matriptase expression shifted from membranous in NM to diffuse in OPMD and OOSCC, similarly to tryptase.Conclusion: Dermokine may represent an early marker of transformation, while altered matriptase patterns could help differentiate dysplasia from carcinoma.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Genome-Wide Association Study of Malignant Transformation of Oral Verrucous Hyperplasia. 口腔疣状增生恶性转化的全基因组关联研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-23 DOI: 10.1111/odi.70037

Yusuf Maulana, Ming-Heng Wu, Wei-Fan Chiang, Wei-Pin Hsiao, Ling-Cheng Mong, Wen-Chang Wang

{"title":"A Pilot Genome-Wide Association Study of Malignant Transformation of Oral Verrucous Hyperplasia.","authors":"Yusuf Maulana, Ming-Heng Wu, Wei-Fan Chiang, Wei-Pin Hsiao, Ling-Cheng Mong, Wen-Chang Wang","doi":"10.1111/odi.70037","DOIUrl":"https://doi.org/10.1111/odi.70037","url":null,"abstract":"Objective: We conducted a genome-wide association study (GWAS) to identify single-nucleotide polymorphisms (SNPs) associated with malignant transformation in oral verrucous hyperplasia (OVH) patients.Methods: The genomic DNA used for SNP genotyping was extracted from the buffy coat. The primary trait of the GWAS was cancer-free survival, defined as beginning at the initial OVH diagnosis and ending at the first diagnosis of oral cancer, loss to follow-up, or the end of follow-up, whichever occurred first. For each SNP, the distributions of cancer-free survival were compared between minor allele carriers and non-carriers using the log-rank test, and an SNP with a significant difference was considered to be associated with OVH malignant transformation.Results: The GWAS identified seven genome-wide significantly associated SNPs (p < 10-7). Among them, four are located in long non-coding RNA genes (STX18-AS1, TARID, LOC124903183, and GNAO1-DT), two are located in protein-coding genes (LIMCH1 and ZBTB44), and the remaining one is located in a non-coding RNA gene (LOC105375416). For each SNP, the minor allele was associated with a higher risk of malignant transformation.Conclusions: This pilot GWAS suggests genetic contributions to OVH malignant transformation. These findings warrant validation in larger samples and replication across diverse populations in future studies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Profit Organizations Advocating for Head and Neck Cancer Patients: A Scoping Review. 倡导头颈癌患者的非营利组织：范围审查。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-23 DOI: 10.1111/odi.70024

Lucas Freitas Carnevali, Camila Barcellos Calderipe, Felipe Silveira Martins, Lauren Frenzel Schuch, Alan Roger Santos-Silva, Manoela Domingues Martins, Vivian Petersen Wagner

{"title":"Non-Profit Organizations Advocating for Head and Neck Cancer Patients: A Scoping Review.","authors":"Lucas Freitas Carnevali, Camila Barcellos Calderipe, Felipe Silveira Martins, Lauren Frenzel Schuch, Alan Roger Santos-Silva, Manoela Domingues Martins, Vivian Petersen Wagner","doi":"10.1111/odi.70024","DOIUrl":"https://doi.org/10.1111/odi.70024","url":null,"abstract":"Purpose: To identify and characterize non-profit organizations (NPOs) from English-speaking countries providing advocacy to individuals with head and neck cancer (HNC) and critically analyze the multifaceted roles played by these NPOs for patients, caregivers, healthcare professionals, and researchers.Methods: A scoping review was conducted through PubMed, Scopus, EMBASE, Web of Science, Google Scholar, ProQuest, and open databases. The data collected on the NPOs were: information on origin, founder background, cancer types addressed, mission, and information and services offered.Results: Twenty-five NPOs were identified, predominantly from the US (n = 10/40%) and UK (n = 10/40%). Most NPOs (n = 16/64%) were founded by survivors and/or their families. The websites provided diverse information, with over 84% (n = 21) covering risk factors, signs, symptoms, and screening/diagnosis. Common services included educational resources, newsletters, and patient support groups. Legal advice was also provided but less frequently. All NPOs promoted fundraising; the majority promoted awareness events, and 40% (n = 10) offered research grant opportunities.Conclusions: NPOs are vital advocates for HNC patients, offering community support and empowerment. Healthcare professionals, by being aware of NPOs and their work, can enhance patient support. Additionally, researchers should view NPOs as essential sources for patient and public engagement, which is increasingly valued by funding agencies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review. 口腔慢性炎症性粘膜疾病的黏附给药系统。未来已经存在。系统评价。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-23 DOI: 10.1111/odi.70042

M E Mauceri, M Coppini, V De Caro, G Di Prima, R Mauceri, V Panzarella, G Giuliana, G Campisi

{"title":"Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review.","authors":"M E Mauceri, M Coppini, V De Caro, G Di Prima, R Mauceri, V Panzarella, G Giuliana, G Campisi","doi":"10.1111/odi.70042","DOIUrl":"https://doi.org/10.1111/odi.70042","url":null,"abstract":"Background: Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are considered the most painful oral inflammatory diseases, with high global prevalence and significant impacts on patients' quality of life. In the last decades, researchers have been exploring mucoadhesive drug delivery systems (MDDS) to improve drugs safety and efficacy through optimized formulations for enhancing patients compliance while addressing the limitations of semisolid products.Objective: To assess the clinical efficacy of different MDDS (e.g., tablets, films, and patches) in treating OLP or RAS by a revision of the literature.Methods: According to PRISMA guidelines, the study assessed the remission of signs and symptoms in terms of decreasing burning sensation, pain severity, and lesion size. The protocol was registered on the PROSPERO database (CRD42024603173) and records identified by Medline/PubMed/Scopus.Results: Thirteen observational studies involving humans affected by OLP or RAS were included. The absence of standardized therapies in terms of MDDS, drug, and dosing regimen was highlighted. All MDDS offered several benefits, including prolonged drug release, protection from mechanical irritation, and pain and inflammation reduction. MDDS improved patients' adherence by minimizing daily applications and systemic side effects.Conclusions: MDDS may represent a promising option for both OLP and RAS treatments, addressing key limitations of traditional formulations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder. 颞下颌紊乱患者的牵涉性疼痛表现及其影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-21 DOI: 10.1111/odi.70021

Beatriz Amaral de Lima-Netto, Paulo César Rodrigues Conti, Rafaela Stocker Salbego, Matheus Herreira-Ferreira, Yuri Martins Costa, Leonardo Rigoldi Bonjardim

{"title":"Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder.","authors":"Beatriz Amaral de Lima-Netto, Paulo César Rodrigues Conti, Rafaela Stocker Salbego, Matheus Herreira-Ferreira, Yuri Martins Costa, Leonardo Rigoldi Bonjardim","doi":"10.1111/odi.70021","DOIUrl":"https://doi.org/10.1111/odi.70021","url":null,"abstract":"Objective: To investigate whether a higher number of sites eliciting referred pain upon palpation is associated with greater impairment in biopsychosocial aspects in TMD patients and identify variables that predict increased referred pain.Methods: This cross-sectional study analyzed data from 77 women with myalgia, assessing the number of sites eliciting referred pain upon palpation in relation to clinical (duration, frequency, intensity, painful body sites, pain-related disability), psychological (stress, anxiety, depression, catastrophizing, sleep quality), and psychophysical variables (mechanical and pressure pain thresholds, temporal summation and conditioned pain modulation).Results: Spearman's correlation revealed a significant correlation between the number of sites eliciting referred pain upon palpation in the orofacial region and both pain intensity and frequency (p < 0.001), as well as with the number of painful body sites (p = 0.009). Negative binomial regression indicated that each additional day of pain in the past week and each additional painful body site were predictors of increases of 10% and 4%, respectively, in the number of sites eliciting referred pain upon palpation.Conclusions: These findings highlight the utility of assessing referred pain sites as a complementary indicator of severity in clinical pain parameters, providing a practical and effective tool for a more comprehensive evaluation of patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0