Oral diseases最新文献

Adverse Events in Nonsurgical Facial Aesthetic Procedures: A Systematic Review and Meta-Analysis. 非手术面部美容过程中的不良事件：系统回顾和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-10-05 DOI: 10.1111/odi.70109

Vitória Maria Sousa Cruz, Sebastião Silvério Sousa-Neto, Caique Mariano Pedroso, Maria Eduarda Pérez-de-Oliveira, Ana Gabriela Costa Normando, Helen Kaline Farias Bezerra, Rafael Tomaz Gomes, Ana Carolina Prado-Ribeiro, Danyel Elias da Cruz Perez, Pablo Agustin Vargas, Alan Roger Santos-Silva

{"title":"Adverse Events in Nonsurgical Facial Aesthetic Procedures: A Systematic Review and Meta-Analysis.","authors":"Vitória Maria Sousa Cruz, Sebastião Silvério Sousa-Neto, Caique Mariano Pedroso, Maria Eduarda Pérez-de-Oliveira, Ana Gabriela Costa Normando, Helen Kaline Farias Bezerra, Rafael Tomaz Gomes, Ana Carolina Prado-Ribeiro, Danyel Elias da Cruz Perez, Pablo Agustin Vargas, Alan Roger Santos-Silva","doi":"10.1111/odi.70109","DOIUrl":"https://doi.org/10.1111/odi.70109","url":null,"abstract":"Objective: To determine the prevalence and clinical profile of treatment-related adverse events (TRAE) associated with: (1) botulinum toxin in the upper face; (2) hyaluronic acid fillers in the lower face and nasolabial folds; and (3) nonsurgical facelifts with absorbable threads.Methods: Searches were conducted in five electronic databases and gray literature. Proportion meta-analyses were performed to estimate the prevalence of TRAE for each type of aesthetic procedure.Results: 42 studies were included. TRAEs were reported in 34.8% of included patients. The highest TRAEs prevalence was associated with hyaluronic acid fillers (63.0%, 95% CI: 35%-84%), followed by nonsurgical facelifts with absorbable threads (20.0%, 95% CI: 8%-41%) and botulinum toxin in the upper face (18.0%, 95% CI: 10%-32%). The most frequently reported TRAEs were swelling (22.4%) and pain (19.0%) for hyaluronic acid fillers; pain (31.5%) and bruising (23.4%) for nonsurgical facelifts with threads; and headache for botulinum toxins. Hyaluronic acid fillers accounted for 67.3% of all TRAEs (n = 3729/4971).Conclusions: The overall prevalence of adverse events was low for botulinum toxin and thread lifts, but high for hyaluronic acid fillers. Future studies should report all adverse events, expected and not expected, detailing the number of patients affected, total events, onset and recovery times, severity, and provider category.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of ChatGPT-4 Plus in Providing Information on Oral Cancer Management. ChatGPT-4 Plus提供口腔癌管理信息的准确性。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-10-03 DOI: 10.1111/odi.70110

Busra Yilmaz, Emine Nur Kahraman, Michael T Brennan, Amardeep S Grewal, Aynur Aktas

{"title":"Accuracy of ChatGPT-4 Plus in Providing Information on Oral Cancer Management.","authors":"Busra Yilmaz, Emine Nur Kahraman, Michael T Brennan, Amardeep S Grewal, Aynur Aktas","doi":"10.1111/odi.70110","DOIUrl":"https://doi.org/10.1111/odi.70110","url":null,"abstract":"Objective: Artificial intelligence (AI)-driven large language models, such as Chat Generative Pre-Trained Transformer (ChatGPT)-4 Plus, are increasingly used for patient education and clinical decision support in oral oncology, although their accuracy in oral cancer (OC) management remains uncertain. This study evaluates the accuracy of ChatGPT-4 Plus responses to clinically relevant questions regarding OC diagnosis, treatment, recovery, and prevention.Methods: A cross-sectional study assessed 65 clinically relevant OC-related questions using a paid ChatGPT-4 Plus subscription without modifications. Three oral medicine specialists and one radiation oncologist rated accuracy on a four-point scoring system. Interrater reliability was measured with the intraclass correlation coefficient (ICC), and chi-square tests were used for comparisons.Results: Among 65 questions, 63% of responses were Score 1, with none rated as Score 4. Score 1 was most frequent in Recovery (72%), followed by Treatment (62%), Prevention (60%), and Diagnosis (55%). Scores 2 and 3 responses were highest in Diagnosis (45%). Recovery had significantly higher Score 1 responses than Diagnosis (p < 0.05), while other comparisons were not significant. ICC ranged from 0.85 to 0.93.Conclusions: ChatGPT-4 Plus provided accurate responses to clinically relevant OC-related questions, particularly regarding recovery. However, diagnostic inconsistencies highlight the need for clinician oversight before integrating AI into practice.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta-Analysis. 口腔白斑的肿瘤特征表达：系统回顾和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70106

I González-Ruiz, P Ramos-García, H Boujemaoui-Boulaghmoudi, N Mjouel-Boutaleb, M A González-Moles

{"title":"Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta-Analysis.","authors":"I González-Ruiz, P Ramos-García, H Boujemaoui-Boulaghmoudi, N Mjouel-Boutaleb, M A González-Moles","doi":"10.1111/odi.70106","DOIUrl":"https://doi.org/10.1111/odi.70106","url":null,"abstract":"Objectives: To assess the available evidence on the expression of hallmarks of cancer and oral leukoplakia (OL) malignant transformation probability, with the goal of identifying the earliest oncogenic molecular events participating in oral cancer carcinogenesis.Methods: Embase, MEDLINE/PubMed, Scopus, and Web of Science were searched for primary-level studies published prior to Sept 24, strictly designed as longitudinal cohorts.Results: A total of 60 studies (9758 OLs) fulfilled the eligibility criteria, and the expression of 68 different biomarkers was evaluated using the immunohistochemical technique. Sustaining proliferation hallmark was frequently harbored by OLs (PP = 56.30%, 95% CI = 43.10-69.09), significantly associated with malignant transformation (RR = 1.92, 95% CI = 1.45-2.55, p < 0.001), and markedly more frequent than in normal oral mucosa (OR = 7.70, 95% CI = 2.22-26.65, p = 0.001). Also related, genome instability markers were considerably overexpressed and associated with oral cancer development (p < 0.05), although resulting from a smaller sample size. Another remarkable finding is related to the activation of proinvasive mechanisms in OLs, representing the epithelial-mesenchymal transition (EMT) phenomenon, which was frequent (PP = 37.30%, 95% CI = 28.21-46.86) and significantly associated with oral cancer (RR = 3.43, 95% CI = 2.67-4.40, p < 0.001). Finally, avoiding immune destruction markers were also overexpressed (PP = 35.77%, 95% CI = 24.66-47.69) and significantly higher in leukoplakias progressing to oral cancer (RR = 3.65, 95% CI = 1.87-7.13, p < 0.001).Conclusions: Malignant transformation of OL is significantly increased in hyperproliferative lesions, which develop the EMT phenomenon and avoid immune destruction through oncogenic mechanisms.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and Prognosis of Ameloblastic Carcinoma: A 20-Year Single-Center Retrospective Study. 成釉细胞癌的流行病学和预后：一项20年单中心回顾性研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70108

Zi-Han Dang, Tao-Min Zhu, Xin-Yu Dou, Chun-Yu Feng, Zi-Han Jiang, Si-Jie Yang, Er-Hui Jiang, Zheng-Jun Shang

{"title":"Epidemiology and Prognosis of Ameloblastic Carcinoma: A 20-Year Single-Center Retrospective Study.","authors":"Zi-Han Dang, Tao-Min Zhu, Xin-Yu Dou, Chun-Yu Feng, Zi-Han Jiang, Si-Jie Yang, Er-Hui Jiang, Zheng-Jun Shang","doi":"10.1111/odi.70108","DOIUrl":"https://doi.org/10.1111/odi.70108","url":null,"abstract":"Backgrounds: Ameloblastic carcinoma, a rare malignant odontogenic tumor, is difficult to diagnosis and treat. Here, we retrospectively analyzed its epidemiology, prognosis, and atypical ameloblastoma, a lesion insufficient to diagnose as ameloblastic carcinoma, to provide insights for understanding.Methods: This study included 23 cases of ameloblastic carcinoma and 31 of atypical ameloblastoma from 2004 to 2024. Epidemiology, clinical symptoms, radiographic features, treatment, and prognosis were analyzed.Results: Regarding ameloblastic carcinoma, 15 males and 8 females ranging from 21 to 85 years old were included, with an average of 51.57. Eleven cases (47.8%) occurred in the maxilla. The main symptom was swelling, and the radiographic features included honeycomb-like features. The prognosis was revealed during the 1- to 19-year follow-up; 11 patients did not experience recurrence, 4 experienced recurrence, 7 died, and 1 was missing. The prognosis analysis revealed site, type and therapy without flap repair might be associated with recurrence, suggesting prompt extended resection might be the preferred treatment. Among patients with atypical ameloblastoma, 2 patients subsequently developed ameloblastic carcinoma, and 5 experienced recurrence.Conclusion: Ameloblastic carcinoma, a rare malignant tumor with high recurrence and mortality rates, and atypical ameloblastoma with a potential for malignancy should receive prompt treatment and rigorous follow-up.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Predictors of Oral Mucosal Melanoma-A Systematic Review and Meta-Analysis. 口腔黏膜黑色素瘤的预后预测因素：系统回顾和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70105

Sofia Sebastian, Monal Yuwanati, Pratibha Ramani

{"title":"Prognostic Predictors of Oral Mucosal Melanoma-A Systematic Review and Meta-Analysis.","authors":"Sofia Sebastian, Monal Yuwanati, Pratibha Ramani","doi":"10.1111/odi.70105","DOIUrl":"https://doi.org/10.1111/odi.70105","url":null,"abstract":"Background: Oral mucosal melanoma (OMM) is a rare, aggressive malignancy; however, prognostic factors for OMM remain poorly defined. This systematic review and meta-analysis aimed to identify prognostic predictors that influence survival outcomes in OMM patients.Methods: PubMed, Web of Science, and Scopus were searched for case reports, case series, and retrospective observational studies involving patients with OMM. Data on demographics, tumor features, and survival were extracted. Meta-analysis was performed using a random-effects model. Study quality was assessed using Murad criteria and the JBI checklist.Results: A total of 16 studies comprising 1151 patients were included in the systematic review; five studies with 942 patients were included in the meta-analysis. The pooled 5-year survival proportion was 34% (95% CI: 24%-45%, I2 = 87%). Key predictors of poor prognosis included tumor size > 4 cm, lymph node metastasis, and non-palatal tumor location. Palatal lesions showed better survival (2-year survival-85%). Treatment primarily involved surgical resection; adjuvant therapies had limited benefit. Neck dissection showed no consistent survival advantage.Conclusions: Tumor size, lymph node involvement, and anatomical site are significant prognostic indicators in OMM. Standardized staging systems incorporating tumor burden and histopathologic markers are essential for improved prognostication.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Role of Ultrasound in the Diagnosis of Oral Lesions: A Scoping Review. 探讨超声在口腔病变诊断中的作用：范围综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70107

Camila Pacheco-Pereira, Sheryn Villarey, Swarna Yerebairapura Math, Konrad Lehmann, Carlos Alberto Figueredo, Fabiana T Almeida

{"title":"Investigating the Role of Ultrasound in the Diagnosis of Oral Lesions: A Scoping Review.","authors":"Camila Pacheco-Pereira, Sheryn Villarey, Swarna Yerebairapura Math, Konrad Lehmann, Carlos Alberto Figueredo, Fabiana T Almeida","doi":"10.1111/odi.70107","DOIUrl":"https://doi.org/10.1111/odi.70107","url":null,"abstract":"Aim: To provide an overview of the diagnostic potential of Ultrasound to assess oral lesions using Magnetic Resonance Imaging, Computed Tomography/Cone-beam computed tomography, or histopathology as the reference standard.Methods: A literature search was conducted from the following databases: OVID Medline and Embase, Web of Science, Pubmed, and Scopus. The Joanna Briggs Institute Checklist for Systematic Reviews and Research Syntheses tool was used to assess the risk of bias.Results: Thirty-four studies were included. One study assessed soft tissue lesions, one study assessed intraosseous lesions, and 32 studies assessed malignancies. Ultrasound demonstrated its ability to recognize biomarkers of a diverse range of soft tissue lesions with sensitivity and specificity over 90%. Sensitivity and specificity over 90% were also found for the detection of ameloblastoma proliferation. From studies investigating malignancies, 32% measured the depth of invasion, and 56% measured tumor thickness. The main method of analysis was correlation in 68% of the studies, followed by 25% of the studies assessing sensitivity and specificity.Conclusion: Ultrasound has the potential to provide accurate information on the characteristics of benign oral lesions and malignancies. It can be used as an initial method of assessment or screening to aid in diagnosis and treatment planning.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lrp5 A241T High-Bone-Mass Mutation Enhances Implant Osseointegration: An Experimental Murine Study. Lrp5 A241T高骨量突变促进种植体骨整合：一项实验小鼠研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70102

Danhong Zhou, Xueting Wang, Hui Zhang, Qifeng Jiang, Qinmeng Zhang, Xiaoyan Miao, Ying Wang, Guoli Yang, Zhiwei Jiang

{"title":"Lrp5 A241T High-Bone-Mass Mutation Enhances Implant Osseointegration: An Experimental Murine Study.","authors":"Danhong Zhou, Xueting Wang, Hui Zhang, Qifeng Jiang, Qinmeng Zhang, Xiaoyan Miao, Ying Wang, Guoli Yang, Zhiwei Jiang","doi":"10.1111/odi.70102","DOIUrl":"https://doi.org/10.1111/odi.70102","url":null,"abstract":"Objectives: This study aimed to assess the effect of the low-density lipoprotein receptor-related protein 5 (Lrp5) A241T gain-of-function mutation, which induces a high-bone-mass phenotype, on implant osseointegration in a murine model.Methods: Heterozygous Lrp5 A241T mutant (Lrp5A/+) and wild-type (WT) littermate male mice on a C57BL/6J background were used. Micro-computed tomography (micro-CT) was performed to assess tibial trabecular bone architecture. Sandblasted and acid-etched (SLA) titanium implants were surgically inserted into the proximal tibiae, and samples were harvested after 4 weeks for micro-CT and histological analysis. Primary osteoblasts were seeded onto SLA titanium sheets and induced for osteogenesis for 7 days. Osteogenic marker expression was assessed by quantitative real-time polymerase chain reaction and western blotting.Results: The Lrp5A/+ group exhibited significantly improved trabecular bone architecture compared to WT controls. At 4 weeks post-implantation, micro-CT revealed greater peri-implant bone formation in the Lrp5A/+ group, while hard tissue sections showed increased bone area and bone-implant contact. HE and Masson staining further confirmed greater new bone formation. After 7 days of in vitro osteogenic induction, Lrp5, Runx2, and Sp7 were significantly upregulated in the Lrp5A/+ group.Conclusions: The Lrp5 A241T mutation significantly enhanced implant osseointegration in a transgenic murine model.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic Analysis of Sarcomas in the Oral and Maxillofacial Region: A Systematic Review. 口腔颌面部肉瘤的临床病理分析：系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-30 DOI: 10.1111/odi.70103

Iara Vieira Ferreira, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Alfio José Tincani, Marcelo Elias Schempf Cattan, Arthur Antolini-Tavares, Albina Altemani, Fernanda Viviane Mariano

{"title":"Clinicopathologic Analysis of Sarcomas in the Oral and Maxillofacial Region: A Systematic Review.","authors":"Iara Vieira Ferreira, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Alfio José Tincani, Marcelo Elias Schempf Cattan, Arthur Antolini-Tavares, Albina Altemani, Fernanda Viviane Mariano","doi":"10.1111/odi.70103","DOIUrl":"https://doi.org/10.1111/odi.70103","url":null,"abstract":"Objective: This study aimed to systematically review primary sarcomas in the oral and maxillofacial region, focusing on patient demographics and sarcoma-specific characteristics, including clinical presentation, histopathology, treatment approaches, outcomes, and survival rates.Materials and methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines and based on the PECOS framework, including observational studies on primary oral and maxillofacial sarcomas. An electronic search in five databases identified eligible studies, and outcomes were analyzed via Kaplan-Meier and Cox regression.Results: The review included 35 studies comprising 687 cases of sarcomas in the oral and maxillofacial region. The mean patient age was 35.26 years, with a slight male predominance. Lesions predominantly involved the mandible, with osteosarcoma being the most common histological subtype. Multimodal treatment was most frequent. Of 616 patients with survival data, 58.1% were alive at analysis. The overall 5-year survival and disease-free survival rates were 54.3% and 60.4%, respectively. Factors such as age, histological type, T classification, stage grouping, surgical margins, local recurrence, and distant metastases significantly influenced survival (p < 0.05).Conclusion: This study provides a comprehensive review of oral and maxillofacial sarcomas, offering data to understand the clinicopathological characteristics of these lesions, helping to improve their diagnosis and management.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-Stroma Ratio, Infiltrating Lymphocytes, and Their Combined Profiles in Oral Cancer Prognosis. 肿瘤-间质比、浸润淋巴细胞及其与口腔癌预后的综合关系。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-22 DOI: 10.1111/odi.70101

Michal Herman, Katerina Kopecka, Jaroslav Michalek, Richard Pink, Jana Zapletalova, Sylva Hotarkova, Michal Hendrych, Michal Mozola, Marketa Hermanova

{"title":"Tumor-Stroma Ratio, Infiltrating Lymphocytes, and Their Combined Profiles in Oral Cancer Prognosis.","authors":"Michal Herman, Katerina Kopecka, Jaroslav Michalek, Richard Pink, Jana Zapletalova, Sylva Hotarkova, Michal Hendrych, Michal Mozola, Marketa Hermanova","doi":"10.1111/odi.70101","DOIUrl":"https://doi.org/10.1111/odi.70101","url":null,"abstract":"Background: Tumor microenvironment and immune response-related histopathological features were identified as potential biomarkers in many tumor types, including oral squamous cell carcinoma (OSCC). We assessed the prognostic significance and correlations of tumor-stroma ratio (TSR), tumor-infiltrating lymphocytes (TILs), and their combined profiles in OSCC.Methods: The study included 114 patients with resected OSCC. Stromal TILs and TSR were evaluated on the hematoxylin and eosin-stained tissue sections according to International Immuno-Oncology Biomarker Working Group criteria and recommendations for the assessment of TSR and categorized (into stroma-high and stroma-low; TILs high and TILs low). Clinicopathological correlations and survival analyses were performed.Results: Correlations of TSR and TILs with clinicopathological parameters, including grade, stage, perineural invasion, and lymph node metastasis, were found. TSR (stroma-high) was independently associated with shortened disease-specific, disease-free, and overall survival. Low TILs were associated with worse survival rates; these associations were not significant in multivariate analysis. However, the combined profiles of TILs with TSR showed a gradually increased risk of recurrence or death, from stroma-low/TILs high to stroma-high/TILs low tumors.Conclusion: The findings support that the evaluation of TSR, TILs, and their combinations provides significant information on OSCC hazard discrimination and prognostication, suggesting their potential implementation in routine pathological reports.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental Spirituality and Religiosity in the Context of Cleft Lip and/or Palate: Emotional Support and Coping. 唇裂和/或腭裂背景下父母的灵性和宗教信仰：情感支持和应对。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-09-22 DOI: 10.1111/odi.70047

Amanda Andrade de Costa, Fabrício Emanuel Soares de Oliveira, Gabriely Caroline Caproni de Oliveira, Verônica Oliveira Dias, Ricardo D Coletta, Daniella Reis Barbosa Martelli, Hercílio Martelli Junior

引用次数: 0