Oral diseases最新文献

Similarities and Differences in Resting-State Brain Activity Changes of Distinct Chronic Pain Types.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-04 DOI: 10.1111/odi.15271

Xiaofei Chen, Ruoyu Tang, Yihan Jin, Liqiang Wu, Yidan Liang, Kuanghui Xu, Ping He, Yun Guo, Jie Li

{"title":"Similarities and Differences in Resting-State Brain Activity Changes of Distinct Chronic Pain Types.","authors":"Xiaofei Chen, Ruoyu Tang, Yihan Jin, Liqiang Wu, Yidan Liang, Kuanghui Xu, Ping He, Yun Guo, Jie Li","doi":"10.1111/odi.15271","DOIUrl":"https://doi.org/10.1111/odi.15271","url":null,"abstract":"Objectives: To explore neural similarities and differences between visceral and somatic pain by comparing spontaneous brain activity in patients with chronic temporomandibular disorder (TMD) and irritable bowel syndrome (IBS).Methods: Twenty eight IBS patients, 21 TMD patients, and 28 healthy controls (HC) underwent resting-state fMRI and behavioral assessments. The correlations between fMRI metrics such as the amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), functional connectivity (FC), and clinical manifestations were further analyzed.Results: Compared with HC, both patient groups demonstrated increased ALFF in right parahippocampal gyrus (PHG), insula, medial superior frontal gyrus (SFGmed), precentral gyrus (PreCG), and increased ReHo in right SFGmed and left supplementary motor area (SMA). Compared with IBS patients, TMD patients exhibited reduced ALFF in right SFGmed and insula, increased ALFF in right PHG and PreCG, decreased ReHo in right SFGmed and left lingual gyrus, and increased ReHo in left SMA. Both patient groups exhibited enhanced right PHG-related FC in left precuneus and right cingulate gyrus, and right insula-related FC in left superior temporal gyrus and right paracentral lobule. Specifically, IBS patients showed higher FC between right PHG and orbitofrontal cortex than TMD patients, which was negatively correlated with mood and gastrointestinal symptoms. Mediation analysis revealed that pain in TMD and gastrointestinal symptoms in IBS mediated these relationships.Conclusion: Visceral and somatic pain share abnormal activity in multiple brain networks. Abnormalities in affective region present potential neuroimaging markers for pain disorders, with depression in somatic pain linked to pain intensity and in visceral pain to gastrointestinal symptoms.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth Loss.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-04 DOI: 10.1111/odi.15272

Sheila Galvin, Bahman Honari, Sviatlana Anishchuk, Claire M Healy, Gary P Moran

{"title":"Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth Loss.","authors":"Sheila Galvin, Bahman Honari, Sviatlana Anishchuk, Claire M Healy, Gary P Moran","doi":"10.1111/odi.15272","DOIUrl":"https://doi.org/10.1111/odi.15272","url":null,"abstract":"Objective: This study aimed to determine if the oral potentially malignant disorder, oral leukoplakia (OLK), exhibited microbiome changes that predict the degree of dysplasia and the risk of malignant progression.Results: We examined the microbiome in 216 swabs of OLK from 177 patients. Compared to healthy controls (n = 120 swabs from 61 patients), who were less likely to smoke and had better oral health, OLK patients exhibited an increased abundance of Rothia mucilaginosa, Streptococcus parasanguinis and S. salivarius, resembling acetaldehyde generating communities described previously. Compared to the patients' healthy contralateral normal (CLN) mucosa (n = 202), which acts as a matched control for oral health parameters, OLK exhibited increased S. infantis, Leptotrichia spp., Bergeyella spp., Porphyromonas spp. and F. nucleatum. Machine learning with clinical and microbiome data could discriminate high-risk dysplasia (moderate to severe) from low-risk dysplasia (none or mild) (sensitivity 87.4%; specificity 76.5%). Follow-up swabs were recovered from 58 patients, eight of whom progressed to a higher grade of dysplasia or OSCC and these eight patients exhibited a higher abundance of Fusobacterium species at their initial presentation.Conclusions: Our study suggests that the OLK microbiome has potential to be an aid to the prediction of dysplasia grade and the risk of malignant transformation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awake Bruxism Is Unrelated to Smoking, Despite the Different Psychological Status: A Pilot Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-30 DOI: 10.1111/odi.15270

Ovidiu Ionut Saracutu, Daniele Manfredini, Alessandro Bracci, Marco Ferrari, Edoardo Ferrari Cagidiaco, Anna Colonna, Matteo Pollis

{"title":"Awake Bruxism Is Unrelated to Smoking, Despite the Different Psychological Status: A Pilot Study.","authors":"Ovidiu Ionut Saracutu, Daniele Manfredini, Alessandro Bracci, Marco Ferrari, Edoardo Ferrari Cagidiaco, Anna Colonna, Matteo Pollis","doi":"10.1111/odi.15270","DOIUrl":"https://doi.org/10.1111/odi.15270","url":null,"abstract":"Objective: The aim of the present study is to get deeper into the complex interplay that might exist between awake bruxism (AB), tobacco smoking, and anxiety and/or depression symptoms in a group of healthy young adults.Materials and methods: The study participants were recruited by advertising the investigation at the University of Siena, Siena, Italy. The inclusion criteria were being in good general health, without systemic diseases or oral diseases. People with ongoing medical or dental treatment and those with a history of systemic disease or temporomandibular disorders were excluded. The participants who were included in the study received a questionnaire containing three sections for the assessment of AB behaviors, anxiety and depression symptoms, and the number of cigarettes smoked.Results: A total of 141 healthy young adults met the inclusion criteria. Different awake masticatory muscle activities showed different strengths of association with anxiety and depression symptoms. However, no relationship was found between the number of smoked cigarettes and the frequency of the various masticatory muscle activities considered.Conclusions: The result of the present study shows no clear-cut association between the frequency of self-reported AB behaviors and smoking in healthy individuals.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Porphyromonas gingivalis Outer Membrane Vesicles (OMVs) on Macrophages in Periodontitis.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-30 DOI: 10.1111/odi.15264

Shuyi Zhang, Yao Jiao, Siyan Liu, Yitong Liu, Yi Liu

引用次数: 0

Family History of Nonsyndromic Orofacial Clefts: A Brazilian Multicenter Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-30 DOI: 10.1111/odi.15273

Leonardo Pereira de Barros, Renato Assis Machado, Lucimara Teixeira das Neves, Daniella Reis Barbosa Martelli, Ana Lúcia Carrinho Ayroza Rangel, Luiz Evaristo Ricci Volpato, Fabrício Emanuel Soares de Oliveira, Ana Laura Herrera Farha, Silvia Regina Almeida de Reis, Danyele Cambraia Franco de Souza, Rafaela Scariot, Ricardo D Coletta, Hercílio Martelli-Júnior

{"title":"Family History of Nonsyndromic Orofacial Clefts: A Brazilian Multicenter Study.","authors":"Leonardo Pereira de Barros, Renato Assis Machado, Lucimara Teixeira das Neves, Daniella Reis Barbosa Martelli, Ana Lúcia Carrinho Ayroza Rangel, Luiz Evaristo Ricci Volpato, Fabrício Emanuel Soares de Oliveira, Ana Laura Herrera Farha, Silvia Regina Almeida de Reis, Danyele Cambraia Franco de Souza, Rafaela Scariot, Ricardo D Coletta, Hercílio Martelli-Júnior","doi":"10.1111/odi.15273","DOIUrl":"https://doi.org/10.1111/odi.15273","url":null,"abstract":"Objective: To summarize the evidence on the relationship between hereditary family history and nonsyndromic orofacial clefts (NSOC) in patients from various Brazilian states.Methods: This cross-sectional multicenter study was conducted at six specialized orofacial cleft services across different regions of Brazil. The sample consisted of 1899 patients with NSOC, including cleft lip only (NSCLO), cleft palate only (NSCPO), and cleft lip and palate (NSCLP). Data were collected from clinical records between June 2023 and May 2024. Family history was classified as positive or negative, with additional details on the number of affected relatives, degree of kinship, and type of oral cleft. Statistical analysis was performed using SPSS version 27.0, with chi-square tests and z tests to assess associations between variables, and Student's t test to compare the mean number of affected relatives among cleft types.Results: Of 1899 patients, 52.6% had NSCLP, 24.11% had NSCPO, and 23.27% had NSCLO. NSCLP and NSCLO were more common in males, while NSCPO was more frequent in females. NSCLP and NSCLO showed similar rates of positive family history, whereas NSCPO had significantly fewer cases with hereditary links. Third-degree relatives were the most affected across all groups.Conclusion: NSCLP and NSCLO showed a higher frequency in males and more cases of positive family history compared to NSCPO. Further studies are needed to explore the genetic basis of NSOC, particularly in genetically diverse populations like Brazil.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trimethylamine N-Oxide (TMAO) and TNF-α Levels in Periodontal Disease Associated With Smoking.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-30 DOI: 10.1111/odi.15262

Ipek Bal, Nur Balci, Cem Sorguc, Hilal Uslu Toygar, Ceyhan C Serdar, Sivge Kurgan, Muhittin A Serdar

{"title":"Trimethylamine N-Oxide (TMAO) and TNF-α Levels in Periodontal Disease Associated With Smoking.","authors":"Ipek Bal, Nur Balci, Cem Sorguc, Hilal Uslu Toygar, Ceyhan C Serdar, Sivge Kurgan, Muhittin A Serdar","doi":"10.1111/odi.15262","DOIUrl":"https://doi.org/10.1111/odi.15262","url":null,"abstract":"Aims: Trimethylamine N-oxide (TMAO) is a compound involved in the pathogenesis of various systemic inflammatory diseases, including cardiovascular conditions. The aim of this study was to determine differences in saliva and serum levels of TMAO between periodontitis and healthy patients according to smoking status.Methods: The study included four systemically healthy groups: periodontally healthy non-smokers (NS-Control; n = 25), non-smokers with Stage-III-Grade-B periodontitis (NS-Periodontitis; n = 25), periodontally healthy smokers (S-Control; n = 25), and smokers with Stage-III Grade-C periodontitis (S-Periodontitis; n = 25). Periodontal parameters were recorded. TMAO levels were determined in saliva and serum samples using liquid chromatography-mass spectrometry (LC-MS/MS). TNF-α levels were measured by the ELISA method.Results: Salivary TNF-α and TMAO levels were significantly elevated in the smoking periodontitis group compared to other groups (p < 0.001 and p = 0.003, respectively). Serum TMAO levels were also significantly higher in the smoking periodontitis group compared to non-smoking controls and non-smoking periodontitis. TMAO/SFR ratios were notably higher in the smoking periodontitis group compared to other groups, and a strong positive correlation was observed between salivary TMAO and TNF-α levels (r = 0.892, p < 0.001).Conclusion: The data suggested that TMAO and TNF-α are associated with inflammatory mechanisms of periodontitis in cases where periodontitis coexists with smoking.Trial registration: NCT06580431.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning for Staging Periodontitis Using Panoramic Radiographs.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-30 DOI: 10.1111/odi.15269

Xin Li, Kejia Chen, Dan Zhao, Yongqi He, Yajie Li, Zeliang Li, Xiangyu Guo, Chunmei Zhang, Wenbin Li, Songlin Wang

{"title":"Deep Learning for Staging Periodontitis Using Panoramic Radiographs.","authors":"Xin Li, Kejia Chen, Dan Zhao, Yongqi He, Yajie Li, Zeliang Li, Xiangyu Guo, Chunmei Zhang, Wenbin Li, Songlin Wang","doi":"10.1111/odi.15269","DOIUrl":"https://doi.org/10.1111/odi.15269","url":null,"abstract":"Objectives: Utilizing a deep learning approach is an emerging trend to improve the efficiency of periodontitis diagnosis and classification. This study aimed to use an object detection model to automatically annotate the anatomic structure and subsequently classify the stages of radiographic bone loss (RBL).Materials and methods: In all, 558 panoramic radiographs were cropped to 7359 pieces of individual teeth. The detection performance of the model was assessed using mean average precision (mAP), root mean squared error (RMSE). The classification performance was evaluated using accuracy, precision, recall, and F1 score. Additionally, receiver operating characteristic (ROC) curves and confusion matrices were presented, and the area under the ROC curve (AUC) was calculated.Results: The mAP was 0.88 when the difference between the ground truth and prediction was 10 pixels, and 0.99 when the difference was 25 pixels. For all images, the mean RMSE was 7.30 pixels. Overall, the accuracy, precision, recall, F1 score, and micro-average AUC of the prediction were 0.72, 0.76, 0.64, 0.68, and 0.79, respectively.Conclusions: The current model is reliable in assisting with the detection and staging of radiographic bone levels.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour-Associated Macrophages in Oral Squamous Cell Carcinoma.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-23 DOI: 10.1111/odi.15265

Akhilanand Chaurasia, Carel Brigi, Arwa Daghrery, Farah Asa'ad, Francesca Spirito, Akira Hasuike, Patricia González-Alva, Dave D Kojic, Revan Birke Koca Ünsal, Gowri Sivaramakrishnan

{"title":"Tumour-Associated Macrophages in Oral Squamous Cell Carcinoma.","authors":"Akhilanand Chaurasia, Carel Brigi, Arwa Daghrery, Farah Asa'ad, Francesca Spirito, Akira Hasuike, Patricia González-Alva, Dave D Kojic, Revan Birke Koca Ünsal, Gowri Sivaramakrishnan","doi":"10.1111/odi.15265","DOIUrl":"https://doi.org/10.1111/odi.15265","url":null,"abstract":"Objective: Tumour-associated macrophages (TAMs) are crucial in the progression and treatment response of oral squamous cell carcinoma (OSCC). TAMs infiltrate OSCC, adopting an M2-like phenotype that promotes tumour growth, metastasis and immune suppression. The current narrative review explored the roles of TAMs in OSCC, focusing on their impact on the tumour microenvironment, invasion, metastasis, angiogenesis, immunosuppression and potential therapeutic targeting.Methods: A comprehensive analysis of the current literature on TAMs in OSCC was conducted. Specifically, we evaluated the biological functions of TAMs, their interactions within the tumour microenvironment, and their influence on disease progression and treatment outcomes.Results: TAMs contribute to OSCC progression by secreting cytokines, such as IL-10 and TGF-β, that inhibit effector immune cells. They facilitate angiogenesis, extracellular matrix remodelling and the epithelial-mesenchymal transition, which are essential for tumour invasion and metastasis. TAMs support cancer stem cells and recruit regulatory T cells and myeloid-derived suppressor cells, enhancing resistance to therapies. Their presence correlates with advanced OSCC stages, lymph node metastasis and poor prognosis.Conclusion: TAMs regulate OSCC progression and therapy resistance. Reprogramming them to an M1-like phenotype or depleting them enhances treatments. Understanding TAM-OSCC interactions is crucial for developing interventions against their tumour-promoting functions and restoring anti-tumour immunity.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Analysis of "Academic Indices Among Oral Pathology and Medicine Fellows in Brazil".

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-23 DOI: 10.1111/odi.15259

Gabriel Lima Braz, Letícia Regina Morello Sartori, Laura Barreto Moreno, Françoise Hélène van de Sande, Marcos Britto Correa, Flavio Fernando Demarco, Luisa Jardim Corrêa de Oliveira, Sarah Arangurem Karam, Francisco Wilker Mustafa Gomes Muniz, Marília Leão Goettems, Maximiliano Sérgio Cenci, Tatiana Pereira-Cenci, Giana da Silveira Lima, Rafael Ratto de Moraes, Alini Cardoso Soares, Luiz Alexandre Chisini, Laylla Galdino Dos Santos, Maísa Casarin, Noéli Boscato, Marina Christ Franco, Helena Silveira Schuch, Ana Carolina Uchoa Vasconcelos, Anelise Fernandes Montagner

引用次数: 0

Programmed Cell Death Tunes Periodontitis.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-23 DOI: 10.1111/odi.15248

Yuejiao Xin, Yixiang Wang

{"title":"Programmed Cell Death Tunes Periodontitis.","authors":"Yuejiao Xin, Yixiang Wang","doi":"10.1111/odi.15248","DOIUrl":"https://doi.org/10.1111/odi.15248","url":null,"abstract":"Objective: To review current knowledge of the various processes of programmed cell death and their roles in immunoregulation in periodontitis.Methods: Relevant literature in the PubMed, Medline, and Scopus databases was searched, and a narrative review was performed. Programmed cell death and the regulation of its various pathways implicated in periodontal infection were reviewed.Results: Multicellular organisms dispose of unnecessary or damaged cells via programmed cell death. Programmed cell death lies at the core of the balance of cell death and survival in pathological progress and infection. Periodontitis is a complex infectious disease involving virulence factors of periodontal pathogens and tightly regulated immune responses of the host. Different types of programmed cell death can play opposite roles in periodontitis or exert their action combinatorially.Conclusion: The coordinated system of various programmed cell death pathways and the extensive crosstalk among them play a fundamental role in the pathophysiology of periodontitis. Illuminating the precise roles and mechanisms of programmed cell death in periodontitis could open up novel therapeutic approaches.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0