Oral diseases最新文献

A Case Control Study to Assess Frequency, Risk Factors and Genetic Diversity of Entamoeba gingivalis. 评估牙龈内阿米巴发生频率、危险因素和遗传多样性的病例对照研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-26 DOI: 10.1111/odi.15391

Elahe Tahmasebi, Mohamad Ghanimatdan, Samira Hajisadeghi, Esmaeil Rafiei, Yosef Sharifi, Zahra Jafari Nodoushan, Leila Khedmat, Mohsen Rahimi

{"title":"A Case Control Study to Assess Frequency, Risk Factors and Genetic Diversity of Entamoeba gingivalis.","authors":"Elahe Tahmasebi, Mohamad Ghanimatdan, Samira Hajisadeghi, Esmaeil Rafiei, Yosef Sharifi, Zahra Jafari Nodoushan, Leila Khedmat, Mohsen Rahimi","doi":"10.1111/odi.15391","DOIUrl":"https://doi.org/10.1111/odi.15391","url":null,"abstract":"Objective: This case-control study aimed to investigate the prevalence of Entamoeba gingivalis subtypes ST1 and ST2 kamaktli in dental plaque samples from individuals referred to Shokri Dental Hospital in Tehran, Iran.Methods: Fifty-three participants were selected for each group (periodontitis, gingivitis, and healthy control), resulting in a total of 159 dental plaque samples. The participants completed a questionnaire to assess risk factors for Entamoeba gingivalis infection. Total genomic DNA was extracted via a commercial kit. Entamoeba gingivalis subtypes were characterized using nested PCR and DNA sequencing.Results: The overall prevalence of Entamoeba gingivalis was 17.6% (28/159). The periodontitis group had the highest prevalence (28.3%, 15/53), followed by gingivitis (17.0%, 9/53) and healthy individuals (7.5%, 4/53). Statistical analysis revealed that the prevalence of Entamoeba gingivalis was significantly greater in periodontal patients than in healthy individuals (p = 0.045). A lower level of education (p = 0.007) and lack of dental flossing (p = 0.000) were significantly associated with higher prevalence. Nested PCR and DNA sequencing identified Entamoeba gingivalis ST1 in 75% (21/28) and ST2-Kamaktli variants in 25% (7/28) of positive samples.Conclusions: Higher Entamoeba gingivalis prevalence in periodontal disease suggests it may contribute to oral pathologies. Understanding risk factors like flossing can enhance prevention and treatment.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply "Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective". 作者回复“灼口综合征的潜在因素：网络视角下的路线图”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-25 DOI: 10.1111/odi.15368

Oscar Gabriel Castaño-Joaqui, Laura Jiménez-Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo

引用次数: 0

Lobodontia-Affected Teeth Exhibit Compromised Integrity and Enamel Defects: A Deep Phenotyping Study. 脑白斑影响的牙齿表现出完整性受损和牙釉质缺陷：一项深入的表型研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-25 DOI: 10.1111/odi.15390

Thanakorn Theerapanon, Narin Intarak, Sasiprapa Prommanee, Sunisa Somkana, Sirinya Kulvitit, Anucharte Srijunbarl, Junji Tagami, Thantrira Porntaveetus

{"title":"Lobodontia-Affected Teeth Exhibit Compromised Integrity and Enamel Defects: A Deep Phenotyping Study.","authors":"Thanakorn Theerapanon, Narin Intarak, Sasiprapa Prommanee, Sunisa Somkana, Sirinya Kulvitit, Anucharte Srijunbarl, Junji Tagami, Thantrira Porntaveetus","doi":"10.1111/odi.15390","DOIUrl":"https://doi.org/10.1111/odi.15390","url":null,"abstract":"Objective: Lobodontia, a complex tooth disorder characterized by carnivore-like dentition, presents unique clinical challenges. This study aimed to characterize the physical, mechanical, and ultrastructural properties of lobodontia teeth to inform precision treatment strategies.Methods: This study included two extracted teeth (one from each lobodontia patient) and ten control teeth from healthy individuals. Clinical, radiographic, dental impression, and microstructural analyses were performed, including colorimetry, surface roughness, microCT, SEM, EDX, nanoindentation, and histology.Results: Lobodontia teeth exhibited a distinctive multitubercular occlusal morphology, with deep grooves and multiple cusps. Radiographs showed dens invaginatus and taurodontism. Compared to controls, lobodontia teeth had increased surface roughness and color deviations. Although mineral composition was similar, lobodontia teeth showed significantly reduced hardness, elastic modulus, enamel thickness, and a disrupted dentinoenamel junction with a pronounced gap between enamel and dentin.Conclusions: Lobodontia teeth exhibit compromised structural integrity, including diminished hardness, elasticity, and enamel thickness, alongside a defective dentinoenamel junction. These characteristics increase the risk of biofilm retention, infection, and malocclusion, necessitating personalized care approaches.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic Head and Neck Necrosis of Bone and Soft Tissue in Cancer Patients. 肿瘤患者的医源性头颈部骨和软组织坏死。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-24 DOI: 10.1111/odi.15378

Alan Roger Santos-Silva, Max J H Witjes, Richard J Shaw, Anastasios Kanatas, Arjan Vissink, Nathaniel S Treister

{"title":"Iatrogenic Head and Neck Necrosis of Bone and Soft Tissue in Cancer Patients.","authors":"Alan Roger Santos-Silva, Max J H Witjes, Richard J Shaw, Anastasios Kanatas, Arjan Vissink, Nathaniel S Treister","doi":"10.1111/odi.15378","DOIUrl":"https://doi.org/10.1111/odi.15378","url":null,"abstract":"Background: Cancer patients are at risk of developing a wide range of treatment-related toxicities that may affect the head and neck region. Iatrogenic necrosis of bone and soft tissue in this area represents a distinct clinical entity characterized by significant complexities and challenges, arising as a consequence of radiotherapy (osteoradionecrosis) or the administration of bone-modifying and/or antiangiogenic therapies (medication-related osteonecrosis of the jaw).Objective: This review provides a comprehensive understanding of this potentially highly impactful complication of cancer therapy and antiresorptive therapy by examining its pathophysiology, risk factors, clinical presentation, and management strategies.Results: Risk factors associated with these conditions include radiotherapy-related variables, medication-related factors, and local predisposing conditions.Conclusion: This review highlights the importance of preventive strategies, including comprehensive dental evaluations and the development of personalized treatment plans before, during, and after cancer therapy, as well as when patients are undergoing or are expected to undergo treatment with bone-modifying medications. By addressing these critical aspects, clinicians can better manage and mitigate the impact of this challenging complication on the quality of life and morbidity outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paediatric Oral and Maxillofacial Malignancies in Kenya and Malaysia. 肯尼亚和马来西亚的儿科口腔和颌面恶性肿瘤。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-23 DOI: 10.1111/odi.15392

Joseph Mutio, Krishan Sarna, Elizabeth A O Dimba, Wambeti Twahir, Wei Cheong Ngeow, Yet Ching Goh

引用次数: 0

Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis. 基质金属蛋白酶-8在牙周病诊断中的准确性：一项meta分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-23 DOI: 10.1111/odi.15389

Dong Zhang, Chao Xu, Mengmeng Liang, Wenting Shao, Peng Wang, Yahong Yang, Kangle Guo

{"title":"Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis.","authors":"Dong Zhang, Chao Xu, Mengmeng Liang, Wenting Shao, Peng Wang, Yahong Yang, Kangle Guo","doi":"10.1111/odi.15389","DOIUrl":"https://doi.org/10.1111/odi.15389","url":null,"abstract":"Background: Matrix metalloproteinase-8 (MMP-8) serves as a biomarker for periodontal diseases; numerous studies have demonstrated its diagnostic accuracy in detecting both periodontitis and gingivitis.Methods: A comprehensive search was performed up to 25 March 2025. Observational studies investigating MMP-8's diagnostic potential for periodontal disease and gingivitis were included. Pooled sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated using Stata 15.1, with diagnostic accuracy measures reported as point estimates and 95% confidence intervals (CI).Results: The meta-analysis included 22 diagnostic studies encompassing 2492 participants. Pooled estimates demonstrated robust diagnostic performance of MMP-8 for periodontal disease, with sensitivity of 0.83 (95% CI: 0.78-0.87), specificity of 0.77 (95% CI: 0.71-0.83), and AUC of 0.87 (95% CI: 0.84-0.90). Subgroup analysis revealed superior accuracy of immunofluorometric assay (IFMA), showing higher sensitivity (0.88) and specificity (0.77) compared to enzyme-linked immunosorbent assay (ELISA, sensitivity/specificity = 0.84/0.76) and point-of-care testing (POCT, sensitivity/specificity = 0.73/0.64). Biological sample comparisons identified gingival crevicular fluid as the optimal source, achieving significantly higher diagnostic accuracy (AUC = 0.91) than mouth rinse (AUC = 0.89) or saliva (AUC = 0.76).Conclusion: Our findings demonstrated that MMP-8 serves as a robust diagnostic biomarker for both periodontitis and gingivitis, with detection methods-IFMA, ELISA, and POCT-showing context-dependent applicability across clinical settings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Contradiction of Innovation: Oral Biosensors for Everything but Oral Diseases. 创新的矛盾：口腔生物传感器的一切，但口腔疾病。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15393

Hichem Moulahoum, Faezeh Ghorbanizamani

引用次数: 0

Risk of Periodontitis in People With Atopic Dermatitis: Real-World Evidences. 特应性皮炎患者牙周炎的风险：真实世界的证据。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15387

Shih-Chi Yang, Hui-Chin Chang, Shiu-Jau Chen, Shuo-Yan Gau

引用次数: 0

Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates. 非人类灵长类动物实验性牙周炎的血管和内皮转录组变化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15385

L M Nguyen, O A Gonzalez, A Balian, S S Kirakodu, J L Ebersole

{"title":"Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates.","authors":"L M Nguyen, O A Gonzalez, A Balian, S S Kirakodu, J L Ebersole","doi":"10.1111/odi.15385","DOIUrl":"https://doi.org/10.1111/odi.15385","url":null,"abstract":"Objective: The molecular features of the alterations in the integrity and function of the periodontal vasculature associated with the initiation/progression of periodontal lesions have not been well elucidated.Methods: This study used a nonhuman primate model of experimental ligature-induced periodontitis across the lifespan to profile transcriptomic responses related to vasculature/endothelial cell biologic activities.Results: In healthy tissues, genes representing EGF receptor signaling, VEGF signaling, and angiogenesis pathways showed some age effects. Disease initiation and/or early progression led to major changes in expression and a large number of vascular/endothelial genes showed correlations across the age groups. Specific bacteria (e.g., Veillonellacease, P. gingivalis, Fusobacterium) were highly correlated with gene changes (e.g., CCL2, CXCL1, EDN2, OCLN, PLAT, SELL, TGFB2). Overall differential expression analytics identified that the disease process appeared as the major controlling factor regarding the vascular/endothelial cell transcriptome.Conclusions: This study supports that alterations in vascular/endothelial cell biologic processes are observed in healthy tissues across the lifespan, with more substantive changes occurring during periodontal disease initiation and early progression. The expression patterns supported critical changes arising in the vasculature of gingival tissues that would contribute to the persistent nature of the immunoinflammatory response in this disease.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial". 对“局部氟西尼特对口腔扁平苔藓演变的影响：随机对照临床试验”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15362

Jianqiu Jin

引用次数: 0