Oral diseases最新文献

Effects of Public Disclosure of a Japanese Celebrity's Oral Cancer: Trends in Oral Cancer Diagnoses. 公开披露日本名人口腔癌的影响：口腔癌诊断的趋势。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-15 DOI: 10.1111/odi.15367

Shihoko Koyama, Takahiro Tabuchi, Kayo Nakata, Toshitaka Morishima, Shuji Uchida, Miki Ishibashi, Isao Miyashiro

{"title":"Effects of Public Disclosure of a Japanese Celebrity's Oral Cancer: Trends in Oral Cancer Diagnoses.","authors":"Shihoko Koyama, Takahiro Tabuchi, Kayo Nakata, Toshitaka Morishima, Shuji Uchida, Miki Ishibashi, Isao Miyashiro","doi":"10.1111/odi.15367","DOIUrl":"https://doi.org/10.1111/odi.15367","url":null,"abstract":"Objective: On February 19, 2019, Chiemi Hori, a renowned Japanese singer, publicly announced her diagnosis of stage IV tongue cancer. The news was widely reported by the Japanese media. This study examined the association between the celebrity's tongue cancer disclosure and trends in the number of oral cancer diagnoses in the national population-based cancer registry (NCR) in Japan.Methods: Data from the NCR were used to plot monthly changes in the number of oral cancer diagnoses from 2016 to 2019 according to sex, age, residential area (divided into five categories based on the density of dentists), cancer site, and clinical stage at initial treatment. Time trends were analyzed using Joinpoint regression.Results: Between 2016 and 2019, 39,415 oral cancer cases were registered. After Ms. Hori's disclosure, oral cancer diagnoses increased significantly, while other head and neck cancers showed no significant changes. The number of oral cancer diagnoses increased from 784 in January 2019 to 1195 in March 2019 (an average monthly change rate of 8.6% from December 2018 to March 2019).Conclusions: There has been a sharp increase in the number of oral cancer diagnoses since the celebrity's disclosure. This suggests that it has raised public awareness of oral cancer.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study. 术中ICG NIF成像定义MRONJ的手术切缘：一项前瞻性观察研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15384

Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, Chengwan Xia, Guowen Sun, Yumei Pu

{"title":"Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study.","authors":"Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, Chengwan Xia, Guowen Sun, Yumei Pu","doi":"10.1111/odi.15384","DOIUrl":"https://doi.org/10.1111/odi.15384","url":null,"abstract":"Background: This study explored the feasibility and effectiveness of indocyanine green (ICG)-based near-infrared fluorescence (NIF) imaging for localizing bone lesions associated with medication-related osteonecrosis of the jaw (MRONJ) during surgical intervention.Methods: A prospective observational study was conducted on 68 patients who underwent surgical treatment for MRONJ at a single institution between January 2021 and April 2024. Among them, 14 patients received surgery guided by NIF imaging, while the remaining patients underwent surgery without NIF guidance. Postoperative follow-up was performed to assess clinical outcomes.Results: There were no significant differences between the two groups regarding age, medication type and duration, underlying disease, lesion location, clinical stage, concomitant symptoms, or surgical approach. NIF imaging remained stable in 14 patients who underwent MRONJ fluorescence surgery. The recurrence rate was lower in the NIF group (14.29%) than in the non-NIF group (27.78%). The difference in the recurrence-free survival curves between the two groups was statistically significant (p = 0.043).Conclusion: ICG-mediated NIF imaging provides a reliable method for identifying MRONJ-related bone lesions and offers valuable intraoperative guidance, potentially improving surgical outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classic Desmoplastic Ameloblastoma: Should It Be a Distinct Subtype of Ameloblastoma?-Based on Clinicopathological, Radiological, Immunohistochemical and Molecular Study of a Large Cohort. 典型的成釉细胞瘤：它应该是成釉细胞瘤的一个独特亚型吗？基于一个大队列的临床病理、放射学、免疫组织化学和分子研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15376

Xiaofeng Zheng, Ronghui Xia, Wenjing Zhu, Chuxiang Qu, Ting Gu, Liam Robinson, Willie van Heerden, Wanninayake Mudiyanselage Tilakaratne, Kelly Magliocca, Merva Soluk-Tekkesin, Akinyele Olumuyiwa Adisa, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Ronell Bologna-Molina, Ricardo Santiago Gomez, Keith David Hunter, Jiang Li

{"title":"Classic Desmoplastic Ameloblastoma: Should It Be a Distinct Subtype of Ameloblastoma?-Based on Clinicopathological, Radiological, Immunohistochemical and Molecular Study of a Large Cohort.","authors":"Xiaofeng Zheng, Ronghui Xia, Wenjing Zhu, Chuxiang Qu, Ting Gu, Liam Robinson, Willie van Heerden, Wanninayake Mudiyanselage Tilakaratne, Kelly Magliocca, Merva Soluk-Tekkesin, Akinyele Olumuyiwa Adisa, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Ronell Bologna-Molina, Ricardo Santiago Gomez, Keith David Hunter, Jiang Li","doi":"10.1111/odi.15376","DOIUrl":"https://doi.org/10.1111/odi.15376","url":null,"abstract":"Objectives: To identify whether the classic desmoplastic ameloblastoma (DA) is an independent subtype of ameloblastoma.Materials and methods: Eighty-six classic DA and 28 hybrid DA cases were retrieved, and available clinical, radiological, and histopathological data were collected. DNA from microdissected tumor tissues were utilized for BRAF V600E, SMOL412F, and CTNNB1 mutation detection. Data of classic DA and hybrid DA were analyzed and compared with each other and with previous reports of conventional ameloblastoma (CA).Results: 69.8% (60/86) of classic DA occurred in the mandible, with the majority affecting the anterior-premolar regions. They were characterized as osteolytic bone expansion (33.8 ± 12.8 mm) with internal bone/calcification (57/58, 98.3%) in radiology. Genetically, classic DA exhibited a high incidence of BRAF V600E mutation (58/62, 93.5%) but no CTNNB1 and SMO L412F mutations. Hybrid DA exhibited similarities to CA in jawbone location, tumor size, and radiology. The recurrence rate of classic DA (9.2%) was lower than that of CA (25.8%).Conclusion: High anterior-premolar distribution, a mixture of osteolytic and internal high-density shadows in radiology, smaller tumor size, compressed epithelium with abundant stroma and scattered bone, consistent mutation of BRAF V600E, and better prognosis all suggest that classic DA may be a distinct clinicopathological subtype of ameloblastoma.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on "Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil". 对“头颈癌预后因素：巴西3052例患者回顾性队列研究”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15380

Efsun Somay

引用次数: 0

Periodontitis Progression During Cardiac Rehabilitation After Acute Coronary Syndrome: Cohort Study. 急性冠状动脉综合征后心脏康复期间牙周炎进展：队列研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15382

Sandra Bibiana Moscoso, Fernan Mendoza, Diana Marcela Castillo, Nathaly Delgadillo, Tammy Goretty Trujillo, David Diaz-Baez, Nestor Rios-Osorio, Juan Manuel Sarmiento, Gloria Inés Lafaurie

{"title":"Periodontitis Progression During Cardiac Rehabilitation After Acute Coronary Syndrome: Cohort Study.","authors":"Sandra Bibiana Moscoso, Fernan Mendoza, Diana Marcela Castillo, Nathaly Delgadillo, Tammy Goretty Trujillo, David Diaz-Baez, Nestor Rios-Osorio, Juan Manuel Sarmiento, Gloria Inés Lafaurie","doi":"10.1111/odi.15382","DOIUrl":"https://doi.org/10.1111/odi.15382","url":null,"abstract":"Objectives: To assess changes in periodontal status and factors related to periodontitis progression in acute coronary syndrome patients who undergo a cardiovascular rehabilitation program following an acute coronary incident.Materials and methods: Fifty-two acute coronary syndrome patients with periodontitis were evaluated during a six-month follow-up period. Periodontal indices were taken at baseline and at 3 and 6 months. Progression of periodontitis was established as clinical attachment loss > 3 mm in two or more teeth at nonadjacent sites. Baseline clinical conditions, microbiological concentration of subgingival biofilm, and risk factors for cardiovascular disease were associated with the incidence of periodontitis progression by a linear mixed-effects model.Results: 57.69% of the patients had severe periodontitis upon admission, and 64.58% presented a progression of periodontitis during the follow-up periods. Hypertension, low HDL, and high levels of T. forsythia in patients with elevated total cholesterol were the best predictors of clinical attachment loss, with a predictability of 99%. At 6 months, 35.41% of patients' high-sensitivity C-reactive protein (hs-CRP) levels remained over the cardiovascular risk range.Conclusions: Periodontal condition deterioration was observed. Hypertension and poor metabolic control were associated with the progression of periodontitis. T. forsythia was the most critical local factor in periodontitis progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Oral Microbiome and Serological Analyses on Association of Alzheimer's Disease and Periodontitis". 对“阿尔茨海默病与牙周炎相关性的口腔微生物组和血清学分析”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15379

Tie-Lou Chen, Ting-Lin Zhang, Hui-Jie Lu, An-Xin Yue, Yan-En Wang, Yi-Jun Zhou, Jin Hou

引用次数: 0

Effects of Integrin-Linked Kinase Silencing Combined With Trichostatin A on Cancer Stem Cells. 整合素连接激酶沉默联合曲古霉素A对肿瘤干细胞的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15377

Yulu Wu, Zhiyong Guo, Zhangao Li, Chenchen Cai, Jiyuan Liu, Xiufa Tang, Lin Que

{"title":"Effects of Integrin-Linked Kinase Silencing Combined With Trichostatin A on Cancer Stem Cells.","authors":"Yulu Wu, Zhiyong Guo, Zhangao Li, Chenchen Cai, Jiyuan Liu, Xiufa Tang, Lin Que","doi":"10.1111/odi.15377","DOIUrl":"https://doi.org/10.1111/odi.15377","url":null,"abstract":"Objectives: Oral squamous cell carcinoma (OSCC) is characterized by high invasiveness and metastasis, with cancer stem cells (CSCs) playing a central role in tumor progression. This study investigates the effects of integrin-linked kinase (ILK) silencing and trichostatin A (TSA) treatment on CSCs, assessing their potential to diminish CSC properties and inhibit OSCC progression.Methods and materials: CSCs were enriched and isolated from primary OSCC samples and Tca8113 cell line and MOC1 cell line using side population (SP) analysis, with their characteristics and the therapeutic impact of treatments assessed through assays such as MTT, wound healing, cell invasion, cell cycle, and apoptosis.Results: Higher SP cell content correlated significantly with poor pathological classification, metastasis, and recurrence. Treated CSCs showed reduced proliferation, migration, and invasion, along with increased apoptosis. In vivo experiments demonstrated that the combined treatment substantially reduced tumor growth.Conclusion: The study confirms the efficacy of targeting CSCs with ILK silencing and TSA treatment in OSCC, suggesting a promising strategy for CSC-directed therapies that merit further investigation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Cancer in the South and South-East Asia Region, 2022: Incidence and Mortality. 南亚和东南亚区域的口腔癌，2022：发病率和死亡率。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15369

Saman Warnakulasuriya, Adalberto M Filho

{"title":"Oral Cancer in the South and South-East Asia Region, 2022: Incidence and Mortality.","authors":"Saman Warnakulasuriya, Adalberto M Filho","doi":"10.1111/odi.15369","DOIUrl":"https://doi.org/10.1111/odi.15369","url":null,"abstract":"Introduction: We present an epidemiological description of cancer of the lip, oral cavity, and oropharynx focused on South and South-East Asia by cancer site, sex, and population.Methods: The number of new cases and deaths from lip, oral cavity, and oropharynx cancers was extracted from GLOBOCAN 2022 and Cancer Incidence in Five Continents. We present age-standardized incidence and mortality rates (ASR) per 100,000 and temporal trends between 1992 and 2017 for four populations in the Region.Results: In 2022, there were 177,258 incident cases and 98,735 deaths from oral cancer in this region. ASR for lip and oral cancer in South and South-East Asia was highest in India (14.67), Sri Lanka (14.04), Bangladesh (13.61) and Pakistan (12.07) in males. The highest age-standardized mortality rates for lip and oral cancer were observed in India (8.17), Bangladesh (8.07) and Pakistan (7.74) for males.Conclusion: Incidence and mortality rates of oral cancer in South and South-East Asia are among the highest globally. 52% of total global deaths from oral cancer are reported from this region. Data suggest a persisting trend and an increase in the incidence of oral cavity cancer among Indian and Bangladeshi males.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Nomogram for Patients With Metastatic Tongue Squamous Cell Carcinoma: A SEER-Based Study. 转移性舌鳞状细胞癌患者的预后图：一项基于seer的研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15381

Yanling Chen, Zhoumiao Qi, Chaoyue Hu, Yanling Yu, Kai Liu

{"title":"Prognostic Nomogram for Patients With Metastatic Tongue Squamous Cell Carcinoma: A SEER-Based Study.","authors":"Yanling Chen, Zhoumiao Qi, Chaoyue Hu, Yanling Yu, Kai Liu","doi":"10.1111/odi.15381","DOIUrl":"https://doi.org/10.1111/odi.15381","url":null,"abstract":"Objective: To construct and validate a predictive nomogram for patients with metastatic tongue squamous cell carcinoma (MTSCC).Methods: From 2010 to 2015, the SEER database was used to gather the clinical information of MTSCC patients. R software was used to establish a nomogram to predict the cancer-specific survival (CSS) probability of MTSCC patients. The nomogram was validated by the concordance index (C-index), the area under the receiver-operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).Results: Following screening, 284 patients were randomized, with 199 people placed in the training cohort and 85 people placed in the validation cohort, at a ratio of 7:3. By using multivariate Cox regression analysis, it was discovered that chemotherapy, lymph node dissection, brain, bone, lung metastases, and N stage were independent risk factors for CSS. The C-index was 0.664 in the training group and 0.683 in the validation group. The AUC of 1-, 3-, and 5-year CSS rates was more than 0.71, and the calibration plot further demonstrated the nomogram's strong validity. DCA showed that the nomogram had good clinical significance.Conclusion: The CSS probability of patients with MTSCC can be reliably and intuitively predicted by the established nomogram model.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confirmatory Factor Analysis of the Oral Epithelial Dysplasia Informational Needs Questionnaire. 口腔上皮发育不良信息需求问卷的验证性因素分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-07 DOI: 10.1111/odi.15375

Waleed Alamoudi, Abdullah Alsoghair, Richeal Ni Riordain, Stefano Fedele, Stephen Porter

{"title":"Confirmatory Factor Analysis of the Oral Epithelial Dysplasia Informational Needs Questionnaire.","authors":"Waleed Alamoudi, Abdullah Alsoghair, Richeal Ni Riordain, Stefano Fedele, Stephen Porter","doi":"10.1111/odi.15375","DOIUrl":"https://doi.org/10.1111/odi.15375","url":null,"abstract":"Objective: The Oral Epithelial Dysplasia Information Needs Questionnaire (ODIN-Q) was developed to assess the informational needs of patients with oral epithelial dysplasia (OED). This study aimed to evaluate the six-factor ODIN-Q model to determine its psychometric properties and alignment with a theoretical framework.Methods: Confirmatory factor analysis (CFA) was conducted with 165 participants to assess the model's fit. Consensus-based standards for selecting health measurement instruments were followed, and five participants per item in the assessment tool were required for effective CFA. Various fit indices, factor loadings and inter-factor correlations were analysed.Results: The CFA results indicated a moderate model fit, which was consistent with other multidimensional patient-reported instruments. The average factor loading for all 33 items was 0.58 (highest = 0.84, lowest = 0.28). Only two items with relatively low loadings (< 0.3) were related to doctors' experience and lifestyle adjustments. Additionally, the ODIN-Q distinguished conceptually distinct domains with low inter-factor correlations (< 0.20).Conclusion: The current six-factor ODIN-Q is a psychometrically sound instrument for assessing the informational needs of individuals with OED. Further cross-cultural assessments of the ODIN-Q are required to demonstrate its cultural sensitivity in other English-speaking patient cohorts and globally.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0