Oral diseases最新文献

Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study. 中国颅面和口腔畸形谱系的多中心研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-27 DOI: 10.1111/odi.15207

Xiaohong Duan, Yulong Zhu, Shuguo Zheng, Yaling Song, Wenmei Wang, Dong Chen, Zhenjin Zhao, Yongchu Pan, Zhuo Chen, Tingting Zhang, Yongqing Huang, Liling Ren, Dandan Ma, Weihong Wang, Shengbin Huang, Qinggao Song, Baisheng Wang, Yan Zheng, Jiang Li, Jianhua Wang, Yanli Zhang, Xinyue Guo, Wenyan Ruan, Jing Wang, Zhongcheng Gong, Xiaofeng Chang, Zhenglin Yuan, Fu Wang, Guangqing Tian, Jing Meng, Zhexuan Bao, Lin Li

{"title":"Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study.","authors":"Xiaohong Duan, Yulong Zhu, Shuguo Zheng, Yaling Song, Wenmei Wang, Dong Chen, Zhenjin Zhao, Yongchu Pan, Zhuo Chen, Tingting Zhang, Yongqing Huang, Liling Ren, Dandan Ma, Weihong Wang, Shengbin Huang, Qinggao Song, Baisheng Wang, Yan Zheng, Jiang Li, Jianhua Wang, Yanli Zhang, Xinyue Guo, Wenyan Ruan, Jing Wang, Zhongcheng Gong, Xiaofeng Chang, Zhenglin Yuan, Fu Wang, Guangqing Tian, Jing Meng, Zhexuan Bao, Lin Li","doi":"10.1111/odi.15207","DOIUrl":"https://doi.org/10.1111/odi.15207","url":null,"abstract":"Objective: Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we aimed to define the spectrum of COMs and analysis its features or possible influencing factors to improve the surveillance and control of the disease.Materials and methods: We organized a multicenter survey of COMs from 19 hospitals in 14 provinces. The clinical data of COM cases were collected from the electronic medical records system, cleaned and aggregated for analysis.Results: A total of 90,895 COM cases with 76 types of diseases were identified from 34,649,545 hospital population. The four most common COMs were supernumery teeth (62.64%), cleft lip and palate (28.53%), microdontia (2.86%), and tooth agenesis (1.70%). The remaining 72 diseases were detected in 3881 cases and were considered to be rare COMs. Moreover, 84.72% of rare COMs also manifested as other malformations or dysfunctions of the bone, skin and other tissues.Conclusions: COMs exhibit age and gender distribution patterns, have multiple types, and significant dental malformations. The diagnostic criteria and registration practices for COMs influence their reported prevalence and temporal trends, necessitating future improvements.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder. 口腔潜在恶性疾病的抗核阳性和恶性转化潜能。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15208

Seok Woo Hong, Jeong-Hyun Kang

{"title":"Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder.","authors":"Seok Woo Hong, Jeong-Hyun Kang","doi":"10.1111/odi.15208","DOIUrl":"https://doi.org/10.1111/odi.15208","url":null,"abstract":"Objective: This multicenter cohort study aimed to investigate the impact of antinuclear antibody (ANA) positivity on the malignant transformation potential of oral potentially malignant disorders (OPMDs) using the Observational Health Sciences and Informatics network tools for the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).Materials and methods: Retrospective cohort data from five medical centers were analyzed. Cox regression and 1:4 propensity score matching followed by aggregated meta-analysis were used to evaluate association between ANA positivity and the risk of oral squamous cell carcinoma (OSCC). The index date was defined as the first day of diagnosis of OPMD. The target and comparator cohorts comprised patients who tested positive and negative for ANA within 180 days before or after the index date, respectively.Results: Among 27,984 OPMD patients, 1302 patients (4.65%) confirmed malignant transformation. Among these, 3035 patients had ANA laboratory data. After 1:4 PS matching, 523 and 1598 patients with positive and negative for ANA were analyzed. Meta-analysis of the hazard ratios demonstrated that ANA positivity significantly increased the risk of malignant transformation compared to ANA negativity.Conclusions: ANA positivity is a significant prognostic marker for predicting malignant transformation in patients with OPMD.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZNF331 Represses the Proliferation of Head and Neck Squamous Cell Carcinoma via Co-Repressor TRIM28. ZNF331 通过协同抑制因子 TRIM28 抑制头颈部鳞状细胞癌的增殖

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15209

Ju Li, Hao Cheng, Yong Zhao, Yunkang Wang, Chen Gong, Renguo Gong, Yan Li

{"title":"ZNF331 Represses the Proliferation of Head and Neck Squamous Cell Carcinoma via Co-Repressor TRIM28.","authors":"Ju Li, Hao Cheng, Yong Zhao, Yunkang Wang, Chen Gong, Renguo Gong, Yan Li","doi":"10.1111/odi.15209","DOIUrl":"https://doi.org/10.1111/odi.15209","url":null,"abstract":"Objective: This study aims to explore the regulatory effect of Zinc Finger Protein 331 (ZNF331), a KRAB domain-containing transcriptional repressor, in Head and Neck Squamous Cell Carcinoma (HNSCC).Materials and methods: Data from The Cancer Genome Atlas (TCGA)-HNSC were analyzed. The roles of ZNF331 in HNSCC cell proliferation, cell cycle progression, and its interacting proteins were explored through in vitro manipulation of ZNF331 expression and in vivo xenograft experiments. The epigenetic mechanisms underlying ZNF331 dysregulation were investigated by assessing its promoter methylation and the effects of DNA methyltransferase (DNMT) knockdown.Results: Patients with higher ZNF331 expression had a significantly improved progression-free interval (PFI). ZNF331 overexpression inhibits HNSCC cell proliferation and induces G2/M arrest, while its knockdown enhances oncogenic features. ZNF331 can downregulate the expression of oncogenes such as DDX5, EIF5A, and SET. ZNF331's tumor-suppressive activity requires TRIM28, a universal co-repressor of KRAB-ZNF proteins. ZNF331 expression is suppressed by DNMT3B-mediated promoter hypermethylation. Selective knockdown of DNMT3B, but not DNMT3A, restored ZNF331 expression.Conclusions: ZNF331 acts as a potential tumor suppressor in HNSCC, whose inactivation through DNMT3B-mediated hypermethylation may contribute to HNSCC tumorigenesis. Restoring ZNF331 expression through targeted epigenetic therapies may offer a novel strategy for the treatment of HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New IPCL Classification Using NBI for Early Detection of OPMDs Malignant Transformation. 利用 NBI 进行新的 IPCL 分类，以早期发现 OPMDs 恶性转化。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15200

Yiming Xu, Tianyu Zhang, Dan Liu, Xuemei Qiu, Feifei Hou, Jiongke Wang, Xiaobo Luo, Hongxia Dan, Yu Zhou, Xing Zeng, Lu Jiang, Qianming Chen

{"title":"New IPCL Classification Using NBI for Early Detection of OPMDs Malignant Transformation.","authors":"Yiming Xu, Tianyu Zhang, Dan Liu, Xuemei Qiu, Feifei Hou, Jiongke Wang, Xiaobo Luo, Hongxia Dan, Yu Zhou, Xing Zeng, Lu Jiang, Qianming Chen","doi":"10.1111/odi.15200","DOIUrl":"https://doi.org/10.1111/odi.15200","url":null,"abstract":"Objectives: Introduce a new intrapapillary capillary loop (IPCL) classification using narrow-band imaging (NBI) to diagnose early malignant transformation in oral potentially malignant disorders (OPMDs).Methods: In the exploratory phase, NBI images from 241 patients with OPMDs and oral squamous cell carcinoma (OSCC) were assessed for three basic IPCL features-dilation, unevenness, and tortuosity-to identify patterns associated with OPMDs malignant transformation. Chi-square analysis and logistic regression differentiated these patterns between low-risk (no/mild dysplasia) and high-risk (moderate/severe dysplasia, invasive carcinoma) lesions, establishing a new classification system. In the validation phase, the system was applied to 90 patients with histopathological results confirming diagnostic accuracy.Results: Four distinct IPCL types were identified: normal, dilated, irregular, and chaotic, with increasing odds ratios for high-risk lesions. The ROC curve had an AUC of 0.913, with irregular and chaotic types providing the best diagnostic performance, achieving sensitivities and specificities of 84.2% and 88.4%, respectively. In the validation phase, the new classification achieved an overall diagnostic accuracy of 84.4% and substantial inter-observer consistency (κ = 0.694).Conclusion: The new IPCL classification effectively identifies high-risk oral lesions, enhancing the diagnostic utility of NBI for early detection of OPMDs malignant transformations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome Analysis of HNSCC by Aggregatibacter actinomycetemcomitans Extracellular Vesicles. 放线菌胞外小泡对 HNSCC 的转录组分析

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-20 DOI: 10.1111/odi.15204

Jae Yeong Ha, Song-Yi Choi, Suk-Jeong Kim, Kristen Jin Seog, Su-Hyung Hong, Heon-Jin Lee

{"title":"Transcriptome Analysis of HNSCC by Aggregatibacter actinomycetemcomitans Extracellular Vesicles.","authors":"Jae Yeong Ha, Song-Yi Choi, Suk-Jeong Kim, Kristen Jin Seog, Su-Hyung Hong, Heon-Jin Lee","doi":"10.1111/odi.15204","DOIUrl":"https://doi.org/10.1111/odi.15204","url":null,"abstract":"Objectives: The role of extracellular vesicles (EVs), also known as outer membrane vesicles (OMVs), secreted by oral bacteria in the progression of head and neck squamous cell carcinomas (HNSCCs), is largely unexplored. This study aimed to investigate the influence of bacterial EVs, specifically those derived from Aggregatibacter actinomycetemcomitans (Aa), on the progression of HNSCC.Materials and methods: FaDu and UMSCC1 cell lines were treated with Aa-derived EVs, and oncogenic activities were assessed. Comprehensive cellular and RNA-sequencing transcriptome analyses were conducted to assess the impact of these EVs on cell cycle progression and gene expression.Results: Our findings reveal that Aa-derived EVs accelerate cell cycle progression through the S and G2 phases and enhance invasion in HNSCC cell lines. RNA-sequencing analysis showed that Aa-derived EVs exert a more significant effect on general transcript expression than on microRNA profiles, except for miR-146a, which is recognized as a key factor in both carcinogenesis and immune modulation.Conclusions: Bacterial EVs, particularly from periodontal pathogens like Aa, are significant modulators within the oral cancer environment, potentially affecting cellular behavior and gene expression profiles. This study highlights the complex relationship between periodontal health and oral carcinogenesis, emphasizing the significant role of bacterial EVs in HNSCC progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental and Craniofacial Anomalies in Fanconi Anemia: A Systematic Review and Additional 46 Reports. 范可尼贫血症的牙齿和颅面畸形：系统综述和其他 46 篇报告

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-20 DOI: 10.1111/odi.15205

Paula Alves da Silva Rocha, Nayara Conceição Marcos Santana, José Alcides Almeida de Arruda, Tania Mara Pimenta Amaral, Victor Zanetti Drumond, Cassius Carvalho Torres-Pereira, Ana Carolina Acevedo, Ariane Berdal, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Benjamin P J Fournier

{"title":"Dental and Craniofacial Anomalies in Fanconi Anemia: A Systematic Review and Additional 46 Reports.","authors":"Paula Alves da Silva Rocha, Nayara Conceição Marcos Santana, José Alcides Almeida de Arruda, Tania Mara Pimenta Amaral, Victor Zanetti Drumond, Cassius Carvalho Torres-Pereira, Ana Carolina Acevedo, Ariane Berdal, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Benjamin P J Fournier","doi":"10.1111/odi.15205","DOIUrl":"https://doi.org/10.1111/odi.15205","url":null,"abstract":"Objective: Fanconi anemia (FA), a rare genetic disorder, has not been comprehensively studied regarding its dental and craniofacial phenotypes. This study aimed to systematically review the available evidence on dental, occlusion, and craniofacial anomalies in individuals with FA and to describe the occurrence of these anomalies in a cohort from two Brazilian referral centers.Materials and methods: Electronic searches were conducted across six databases, supplemented by manual searches and gray literature. The Brazilian cohort included 46 patients diagnosed with FA.Results: A total of 19 articles describing 158 cases of FA were analyzed. The estimated prevalence of dental/craniofacial anomalies ranged from 13.3% to 71.4%. In our cohort, 93.5% of patients exhibited anomalies, primarily root abnormalities (69.6%), tooth rotation (54.3%), and tooth agenesis (26%). Males (p = 0.031) and individuals with endocrine disorders (p = 0.047) were more likely to experience alterations in eruption and/or exfoliation. Anomalies in size and shape were significantly more prevalent among individuals who had undergone hematopoietic stem-cell transplantation at age 14 or older (p = 0.002).Conclusion: The high occurrence of dental/craniofacial anomalies in individuals with FA suggests that these anomalies are part of the disease's phenotypic spectrum, emphasizing the need to expand and standardize the diagnostic criteria of the disease.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms Underlying Medication-Related Osteonecrosis of the Jaw. 与药物相关的颌骨坏死的机制

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-18 DOI: 10.1111/odi.15198

Kyeongho Lee, Kihun Kim, June Yeon Kim, Jin-Woo Kim, Young-Hoon Kang, Yun Hak Kim, Sung-Jin Kim

{"title":"Mechanisms Underlying Medication-Related Osteonecrosis of the Jaw.","authors":"Kyeongho Lee, Kihun Kim, June Yeon Kim, Jin-Woo Kim, Young-Hoon Kang, Yun Hak Kim, Sung-Jin Kim","doi":"10.1111/odi.15198","DOIUrl":"https://doi.org/10.1111/odi.15198","url":null,"abstract":"Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but debilitating disease characterized by a progressive necrosis of jaw bones in patients who have received anti-resorptive or anti-angiogenic therapies. Unfortunately, we still have no validated preventive or pharmaceutical interventions to help these patients, primarily due to our limited understanding of MRONJ pathogenesis. Here, we offer an extensive review of recent studies relevant to MRONJ pathogenesis. We present a hypothesis regarding the coupling of bone resorption and angiogenesis that relies on osteoblast-derived, matrix-bound vascular endothelial growth factors to explain why ONJ is associated with both anti-resorptive and anti-angiogenic agents.Methods: A narrative review was conducted by searching databases, including PubMed, Scopus, Google Scholar, and Web of Science, to retrieve relevant reports.Results: Reduced bone resorption leads to reduced angiogenesis, and vice versa, creating a vicious cycle that ultimately results in ischemic necrosis of the jaw. Additionally, we suggest that reduced angiogenesis, induced by anti-resorptive or anti-angiogenic agents, aggravates bacterial infection-induced bone necrosis, explaining why the jaw bone is particularly susceptible to necrosis.Conclusion: Our novel hypothesis will facilitate the advancement of future research and the development of more targeted approaches to managing MRONJ.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth. 活性基质金属蛋白酶-8、髓过氧化物酶与牙周病、早产的关系

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-14 DOI: 10.1111/odi.15202

Murat Alan, Timo Sorsa, Pınar Meriç Kantar, Ismo T Raisanen, Önder Gürlek, Burcu Kanmaz, Nurcan Buduneli

{"title":"Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth.","authors":"Murat Alan, Timo Sorsa, Pınar Meriç Kantar, Ismo T Raisanen, Önder Gürlek, Burcu Kanmaz, Nurcan Buduneli","doi":"10.1111/odi.15202","DOIUrl":"10.1111/odi.15202","url":null,"abstract":"Objective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters.Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries. aMMP-8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non-parametric tests.Results: PTBE group exhibited higher full-mouth probing depth and clinical attachment loss values than the other two groups (p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups (p < 0.05). Serum aMMP-8 and MPO concentrations were higher in PTPE group than in the other groups (p < 0.05). Placenta aMMP-8 level was higher in the control group than in the PTPE group (p < 0.05). There was no significant difference between the groups in the placenta MPO levels (p > 0.05).Conclusions: Within the limits of this cross-sectional study, it may be suggested that serum aMMP-8 and MPO concentrations together with placenta aMMP-8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Liver Clots" in Periodontology: A 10-Year Clinical Experience. 牙周病学中的 "肝血块"：10 年临床经验

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15190

Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Kumara Raja, Sukhbir Singh Chopra

{"title":"\"Liver Clots\" in Periodontology: A 10-Year Clinical Experience.","authors":"Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Kumara Raja, Sukhbir Singh Chopra","doi":"10.1111/odi.15190","DOIUrl":"https://doi.org/10.1111/odi.15190","url":null,"abstract":"Objectives: \"Liver clots\" are an uncommon complication following periodontal surgery, characterized by their distinctive gelatinous consistency and color resembling 'liver' tissue. Despite anecdotal reports, there is a lack of comprehensive evidence in the literature regarding its incidence, etiopathogenesis and optimal management strategies. This study aimed to address this knowledge gap by retrospectively analyzing cases to provide insights into this unusual post-operative complication.Materials and methods: In this retrospective descriptive study, data spanning a decade (June 2013-June 2024) were collected from various dental centres. The data included patient demographics, medical history, surgical procedures performed, occurrence of \"liver clot\" formation, management measures and treatment outcomes.Results: The 10-year retrospective data revealed a 2.03% incidence of \"liver clots\" among various periodontal procedures. The highest occurrence was observed following dental extractions, followed by periodontal surgical procedures. The observations also indicated a higher frequency in systemically healthy individuals.Conclusion: \"Liver clot\" formation is a rare, but specific complication after periodontal surgery. Minimally invasive management approaches are effective, highlighting the importance of vigilance and prompt intervention for optimal patient outcomes. Further research is warranted to elucidate the exact etiopathogenesis and to establish evidence-based management protocols for this unusual complication.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply: "Hydroxychloroquine Is Effective in Oral Lichen Planus". 作者的回复："羟氯喹对口腔扁平苔藓有效》。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15178

Yulang Xie, Hao Xu, Yu Zhou, Qianming Chen

引用次数: 0