Oral diseases最新文献

Authors' reply “Osteoradionecrosis incidence in preradiation teeth extractions: A prospective study”

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-18 DOI: 10.1111/odi.15114

Cosimo Rupe, Gioele Gioco, Mariangela Massaccesi, Luca Tagliaferri, Francesco Pastore, Francesco Micciché, Jacopo Galli, Dario Mele, Maria Lucia Specchia, Alessandra Cassano, Massimo Cordaro, Carlo Lajolo

引用次数: 0

Prognostic impact of caspase‐8 mutation in oral cavity squamous cell carcinoma 口腔鳞状细胞癌中 Caspase-8 基因突变的预后影响

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-18 DOI: 10.1111/odi.15124

Hsueh‐Ju Lu, Chun‐Wen Su, Shih‐Chi Su, Lun‐Ching Chang, Ming‐Fang Wu, Chiao‐Wen Lin, Shun‐Fa Yang

{"title":"Prognostic impact of caspase‐8 mutation in oral cavity squamous cell carcinoma","authors":"Hsueh‐Ju Lu, Chun‐Wen Su, Shih‐Chi Su, Lun‐Ching Chang, Ming‐Fang Wu, Chiao‐Wen Lin, Shun‐Fa Yang","doi":"10.1111/odi.15124","DOIUrl":"https://doi.org/10.1111/odi.15124","url":null,"abstract":"ObjectiveIdentifying the drive genes and inhibiting their significant signals were persistently the main concepts in cancer treatment. However, for oral cavity squamous cell carcinoma (OCSCC), the most influential genes for overall survival (OS) remain unclear.MethodsA total of 120 OCSCC patients with corresponding pathologic specimens were collected in Taiwan. Whole‐exome sequencing was done and the prognostic impact of each gene was analyzed. TCGA database was used to validate.ResultsThe incidences of caspase‐8 mutation were 22.1% and 10.9% in the Taiwan and TCGA cohort, respectively. In the Taiwan cohort, caspase‐8 mutation was the most significant independent for OS with an adjusted hazard ratio (HR) ([95% CI]: 3.83 [1.84–7.99]). It was validated by the TCGA database (HR [95% CI]: 1.51 [1.00–2.29]). The 5‐year OSs of the patients with or without caspase‐8 mutation were 38.1% vs. 75.3% (p < 0.001) (HR [95% CI]: 3.264 [1.645–6.438]) in the Taiwan cohort, and 26.1% vs. 49.0% (p = 0.048) (1.513 [1.001–2.288]) in the TCGA cohorts, respectively. Caspase‐8 mutation was also individually associated with poor prognosis for TNM stage I/II/III/IV, respectively. CASP8 R127* and R494*, defined as pathogenic mutations in ClinVar, were presented in both cohorts.ConclusionsCaspase‐8 mutation was the most significant genetic alteration impacting prognosis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAF‐secreted COL5A2 activates the PI3K/AKT pathway to mediate erlotinib resistance in head and neck squamous cell carcinoma CAF 分泌的 COL5A2 激活 PI3K/AKT 通路，介导头颈部鳞状细胞癌的厄洛替尼耐药性

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-17 DOI: 10.1111/odi.15130

Yibo Guo, Mingtao Chen, Jie Yang, Wenkai Zhou, Guanying Feng, Yang Wang, Tong Ji, Yu Zhang, Zheqi Liu

{"title":"CAF‐secreted COL5A2 activates the PI3K/AKT pathway to mediate erlotinib resistance in head and neck squamous cell carcinoma","authors":"Yibo Guo, Mingtao Chen, Jie Yang, Wenkai Zhou, Guanying Feng, Yang Wang, Tong Ji, Yu Zhang, Zheqi Liu","doi":"10.1111/odi.15130","DOIUrl":"https://doi.org/10.1111/odi.15130","url":null,"abstract":"ObjectiveTo investigate the mechanisms behind acquired resistance to erlotinib in head and neck squamous cell carcinoma (HNSCC) with a focus on the role of cancer‐associated fibroblasts (CAFs) and the PI3K/AKT signaling pathway.Materials and MethodsThis study analyzed gene expression profiles of erlotinib‐sensitive and ‐resistant HNSCC cell lines using datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. It included microarray and RNA‐sequencing data, differentially expressed genes (DEGs) analysis, and pathway enrichment. In vitro experiments assessed the functional role of CAFs and the impact of the extracellular matrix component COL5A2 on erlotinib resistance.ResultsWe identified 124 DEGs associated with erlotinib resistance, with key genes like COL5A2 significantly upregulated. CAFs were found to highly express COL5A2, enhancing erlotinib resistance by activating the PI3K/AKT pathway. Higher erlotinib resistance scores correlated with increased infiltration of CAFs.ConclusionsErlotinib resistance in HNSCC is significantly influenced by the tumor microenvironment (TME), particularly through CAFs and the PI3K/AKT pathway. Targeting these mechanisms may offer new therapeutic strategies to overcome resistance in HNSCC patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OSR1 suppresses oral squamous cell carcinoma proliferation and migration via the AXIN2/β‐catenin pathway OSR1 通过 AXIN2/β-catenin 通路抑制口腔鳞状细胞癌的增殖和迁移

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-17 DOI: 10.1111/odi.15135

Xintong Guo, Xinyi Du, Gaoye Zhao, Chongshen Liu, Jing Gao, Zunzhi Huang, Wei Dong

{"title":"OSR1 suppresses oral squamous cell carcinoma proliferation and migration via the AXIN2/β‐catenin pathway","authors":"Xintong Guo, Xinyi Du, Gaoye Zhao, Chongshen Liu, Jing Gao, Zunzhi Huang, Wei Dong","doi":"10.1111/odi.15135","DOIUrl":"https://doi.org/10.1111/odi.15135","url":null,"abstract":"ObjectivesThe odd‐skipped related transcription factor 1 (OSR1) gene exerts distinct regulatory effects on tumorigenesis and development in various cancer types. However, the precise role of OSR1 in oral squamous cell carcinoma (OSCC) remains to be elucidated.MethodsGEPIA 2 and TCGA databases were utilized to analyze the OSR1 expression in head and neck squamous cell carcinoma (HNSC) patients and its impact on prognosis. Hematoxylin–eosin staining, immunohistochemistry, immunofluorescence, western blotting, and RT‐qPCR were employed to detect the OSR1 expression in OSCC tissues and cells. Lentivirus transfection was utilized for overexpression and downexpression of OSR1 in OSCC. CCK8 cell proliferation assay, colony formation and cell scratch assay were conducted to investigate the effects of OSR1 on biological behavior of OSCC cells. Western blotting and RT‐qPCR were applied to investigate the regulatory mechanism of OSR1 on AXIN2/β‐catenin signaling pathway.ResultsOSR1 expression was significantly decreased in HNSC patients, OSCC tissues and cells, leading to a decrease in 5‐year survival rate. OSR1 overexpression inhibited the proliferation and migration of OSCC cells, and the AXIN2/β‐catenin signaling pathway was inhibited. Silencing OSR1 had the opposite effect.ConclusionsOSR1 functioned as a tumor suppressor gene in OSCC proliferation and migration by regulating the AXIN2/β‐catenin signaling pathway.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effects of acupuncture methods on the temporomandibular disorder: A network meta‐analysis

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-17 DOI: 10.1111/odi.15131

Qiuying Yan, He Bu, Guixing Xu, Min Jia, Dehua Li

{"title":"Comparison of the effects of acupuncture methods on the temporomandibular disorder: A network meta‐analysis","authors":"Qiuying Yan, He Bu, Guixing Xu, Min Jia, Dehua Li","doi":"10.1111/odi.15131","DOIUrl":"https://doi.org/10.1111/odi.15131","url":null,"abstract":"ObjectivesA network meta‐analysis (NMA) was applied to compare the therapeutic effect of different acupuncture methods on temporomandibular disorder (TMD).Materials and MethodsA computer retrieval was carried out in the English databases of Cochrane, PubMed, Embase and Web of Science, as well as the Chinese databases of CNKI, Wanfang and VIP for randomized controlled trials on the effect of acupuncture on TMD, with a retrieval deadline of January 21, 2024. Data analysis was conducted using R software and Bayesian method. The pain score served as the primary outcome measure, with the mouth opening as the secondary outcome measure.ResultsThirty‐five articles were included in the analysis, involving 1937 TMD patients. The NMA results suggested that DN‐PT had the best effect on relieving pain and improving mouth opening. (Description of all abbreviations in Supplementary Material S3).ConclusionsBased on the available evidence, the results of the NMA suggest that DN‐PT is most effective in relieving TMD pain and increasing mouth opening. However, due to the fact that some acupuncture therapies are only reported in a small number of research reports, this may lead to an increase in the randomness of the results and a decrease in the reliability.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral squamous cell carcinoma identification by FTIR spectroscopy of oral biofluids

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-17 DOI: 10.1111/odi.15128

Teresa Lapa, Ricardo N. M. J. Páscoa, Filipe Coimbra, Luís Medeiros, Pedro S. Gomes

引用次数: 0

Emerging roles of the renin‐angiotensin system in select oral diseases 肾素-血管紧张素系统在某些口腔疾病中的新作用

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-09 DOI: 10.1111/odi.15134

Yixing Liu, Zhe Liu

{"title":"Emerging roles of the renin‐angiotensin system in select oral diseases","authors":"Yixing Liu, Zhe Liu","doi":"10.1111/odi.15134","DOIUrl":"https://doi.org/10.1111/odi.15134","url":null,"abstract":"ObjectivesThe renin‐angiotensin system (RAS) plays essential roles in cardiovascular and renal function regulation. Recent studies have shown that the RAS components are widely expressed in oral tissues, but their roles in oral diseases remain underexplored. This review aims to summarize the effects of the RAS in select oral diseases including oral squamous cells carcinoma (OSCC), periodontitis, oral submucous fibrosis (OSF), and ageusia/dysgeusia.Subjects and MethodsData searches were performed using PubMed, Web of Science and Scopus through July 2024. A narrative overview of current literature was undertaken to synthesize the contexts with elaboration and summary.ResultsIn OSCC, ACE/Ang II/AT1R promotes OSCC by inducing angiogenesis, cell proliferation and invasiveness. Conversely, ACE/Ang II/AT2R and ACE2/Ang (1–7)/MasR inhibit OSCC progressions. In periodontitis, ACE/Ang II/AT1R upregulates inflammatory cytokines and promotes osteoclast differentiation factor RANKL, whereas ACE2/Ang (1–7)/MasR exerts opposite effects by preventing inflammation and alveolar bone loss. In OSF, Ang (1–7) counters the profibrotic and proinflammatory action of Ang II. In dysgeusia, Ang II suppresses salt taste responses and enhances sweet taste sensitivities, while Ang (1–7) exhibits opposite effects.ConclusionsThe RAS cascade plays crucial roles in OSCC, periodontitis, OSF and ageusia/dysgeusia. The imbalanced RAS may aggravate the progression of these diseases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.8 3区医学

Oral diseases Pub Date : 2024-09-09 DOI: 10.1111/odi.15133

Bruna Carolina Coelho da Silva, Cássia Emanuella Nóbrega Malta, Marcela Maria Fontes Borges, Fernanda Coelho Fontenele, Francisco Whitney Ramalho da Silva Oliveira, Andressa Fernandes de Souza Mourão Feitosa, Ana Camila Xavier Lopes, Gladyson Lucas Rodrigues Aguiar, Lievin Matos Rebouças, Paulo Goberlânio de Barros Silva

引用次数: 0

Risk factors and incidence of oral tumors: Findings from a longitudinal population-based study. 口腔肿瘤的风险因素和发病率：一项基于人群的纵向研究结果。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-09-05 DOI: 10.1111/odi.15125

Young-Taek Kim, Min-Jin Kang, Bo-Ah Lee, Sang-Hoon Kang, Reuben H Kim

{"title":"Risk factors and incidence of oral tumors: Findings from a longitudinal population-based study.","authors":"Young-Taek Kim, Min-Jin Kang, Bo-Ah Lee, Sang-Hoon Kang, Reuben H Kim","doi":"10.1111/odi.15125","DOIUrl":"https://doi.org/10.1111/odi.15125","url":null,"abstract":"Objective: This study investigated risk factors contributed to benign and malignant oral tumors using longitudinal cohort big data.Materials and methods: We included individuals aged ≥40 years who participated in the National Health Examination in South Korea between 2003 and 2004. National Health Insurance claims data after 16 years were used to determine the incidence of oral tumors and the related risk factors. Hazard ratios were calculated using the Cox proportional hazard regression.Results: A total of 5,992,671 participants were included. The incidence of oral cancer was significantly higher in men and increased with age, whereas that of benign tumors was unaffected by sex and decreased with age. Periodontal disease was associated with the incidence of oral cancer but not benign tumors. Soft tissue diseases were associated with both benign and malignant tumors. Various systemic diseases influence the development of oral tumors. Light alcohol consumption reduced the incidence of oral tumors, whereas heavy alcohol consumption increased the incidence of malignant tumors only. Smoking increased the incidence of benign but not malignant tumors.Conclusion: Recognized risk factors such as sex, age, comorbidities, and dental diseases were associated with oral tumors. Alcohol consumption and smoking were not significantly associated with malignant tumors.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on 'Osteoradionecrosis incidence in pre-radiation teeth extractions: A prospective study. 就 "辐射前拔牙的骨坏死发生率 "发表评论：前瞻性研究

IF 2.9 3区医学

Oral diseases Pub Date : 2024-09-03 DOI: 10.1111/odi.15113

Efsun Somay, Duriye Ozturk, Erkan Topkan

引用次数: 0