Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70097
Efsun Somay
{"title":"Re \"Effects of Bisphosphonates and Denosumab on Dental Implants: A Systematic Review With Meta-Analysis\".","authors":"Efsun Somay","doi":"10.1111/odi.70097","DOIUrl":"https://doi.org/10.1111/odi.70097","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70086
Anna Maria Camarda, Giulia Fontana, Barbara Vischioni, Amelia Barcellini, Maria Bonora, Jessica Franzetti, Nadia Facchinetti, Federica Serra, Carmine Tinelli, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Pierluigi Bonomo, Sara Colombo, Daniela Alterio, Nicola Alessandro Iacovelli, Marzia Franceschini, Giovanni Ivaldi, Marco Trovò, Elisa D'Angelo, Ester Orlandi
{"title":"COMBINATORIC: Carbon Ion Boost With Photons or Protons in Salivary Gland and Sinonasal Cancers.","authors":"Anna Maria Camarda, Giulia Fontana, Barbara Vischioni, Amelia Barcellini, Maria Bonora, Jessica Franzetti, Nadia Facchinetti, Federica Serra, Carmine Tinelli, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Pierluigi Bonomo, Sara Colombo, Daniela Alterio, Nicola Alessandro Iacovelli, Marzia Franceschini, Giovanni Ivaldi, Marco Trovò, Elisa D'Angelo, Ester Orlandi","doi":"10.1111/odi.70086","DOIUrl":"https://doi.org/10.1111/odi.70086","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the outcomes of combining carbon ion radiotherapy boost (CIRTb) with photons (Ph) or protons (PT) for locally advanced salivary gland and sinonasal cancers (SGCs and SNCs).</p><p><strong>Materials and methods: </strong>Sixty-nine patients with SGCs and SNCs received CIRTb to high-risk CTV and Ph or PT to low-risk CTV (LR-CTV) from October 2014 to September 2022. Two-year local relapse-free survival (LRFS) was analyzed with Kaplan-Meier. Toxicity according to Common Terminology Criteria for Adverse Events v5. Variables affecting toxicities were analyzed with chi-squared and Mann-Whitney U tests.</p><p><strong>Results: </strong>Patients received a median CIRTb dose of 15 Gy RBE, with 29 (41%) receiving Ph and 42 (59%) receiving PT. With a median follow-up of 17.23 months, 2-year LRFS achieved 87.8% (95% CI: 79.6-96.8). Female (p = 0.045) reported better 2-year LRFS rates: 95.2% (95% CI: 86.6-100) versus 81.8% (95% CI: 69.5-96.2). Acute and late G2+ toxicity were, respectively, 80% and 60%. Ph (p = 0.004) and smaller LR-CTV (p = 0.004) reduced acute and late toxicities. No G4 late toxicity was reported.</p><p><strong>Conclusions: </strong>CIRT combined with Ph or PT seems a valuable option for locally advanced SGCs and SNCs. Prospective studies are needed to select the best treatment combination.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70091
Cristina Saldivia-Siracusa, Alessandro Villa, Alan Roger Santos-Silva
{"title":"Crying and Emotional Distress Among Patients in Oral Medicine: A Common and Challenging Scenario.","authors":"Cristina Saldivia-Siracusa, Alessandro Villa, Alan Roger Santos-Silva","doi":"10.1111/odi.70091","DOIUrl":"https://doi.org/10.1111/odi.70091","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cinnamon-Induced Contact Stomatitis: A Retrospective Study of 74 Cases and Literature Review.","authors":"Eleni-Marina Kalogirou, Aikaterini Aktypi-Bampouranou, Marianna Vasilaki, Konstantina Chatzidimitriou, Konstantinos I Tosios","doi":"10.1111/odi.70081","DOIUrl":"https://doi.org/10.1111/odi.70081","url":null,"abstract":"<p><strong>Objective: </strong>Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.</p><p><strong>Materials and methods: </strong>This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used. The literature was reviewed for similar CCS cases, documented by relevant history and at least one clinical/histopathological image.</p><p><strong>Results: </strong>Seventy-four patients were diagnosed with CCS that mainly involved the buccal mucosa (67/74) and/or lateral tongue (50/74). White lichenoid or plaque-type lesions were observed in seven patients, erythematous/erosive/ulcerative lesions in 26 patients, and combined whitish-red lesions in 41 patients. Discontinuation of CCPs resulted in complete resolution within a week in all cases. The literature review yielded 40 well-documented cases of CCS related to chewing gums, candies, or mints.</p><p><strong>Conclusion: </strong>The presence of erythematous and/or white lesions at the occlusal plane should raise suspicion of CCS that can be diagnosed based on the patient's history and clinical presentation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-07DOI: 10.1111/odi.70092
Renato Assis Machado, Sara Garcia Azevedo, Lilianny Querino Rocha de Oliveira, Hercílio Martelli Júnior, Ricardo D Coletta
{"title":"Authors' Reply \"Tooth Anomalies in Patients With Nonsyndromic Orofacial Cleft: A Systematic Review and Meta-Analysis\".","authors":"Renato Assis Machado, Sara Garcia Azevedo, Lilianny Querino Rocha de Oliveira, Hercílio Martelli Júnior, Ricardo D Coletta","doi":"10.1111/odi.70092","DOIUrl":"https://doi.org/10.1111/odi.70092","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-07DOI: 10.1111/odi.70076
Piaopiao Chen, Mao Li, Qiong Zhang, Minxia Qiu, Xuefen Yu
{"title":"Effects of an Oral Health Management Program During Pregnancy: A Randomized Controlled Trial.","authors":"Piaopiao Chen, Mao Li, Qiong Zhang, Minxia Qiu, Xuefen Yu","doi":"10.1111/odi.70076","DOIUrl":"https://doi.org/10.1111/odi.70076","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of a Health Belief Model-based oral health management program on self-efficacy, oral health behaviors, and three periodontal clinical indicators among pregnant women.</p><p><strong>Study design: </strong>A randomized controlled trial was conducted with 65 participants randomly allocated to the intervention (n = 39) and control (n = 26) groups. The intervention included one face-to-face education, three video calls, two online lectures, and regular follow-up supervision in 1 month, while the control group received one face-to-face education. Self-efficacy for oral self-care, three periodontal clinical indicators, and oral health behaviors were measured at baseline (T<sub>0</sub>), post-intervention (T<sub>1</sub>), and 2-month follow-up (T<sub>2</sub>).</p><p><strong>Results: </strong>The total and three domains' scores on the Self-efficacy Scale for Self-care in the intervention group increased appreciably (p < 0.001). Oral health behaviors among the intervention group exhibited more remarkable improvement than the control group did at the two post-baseline times (all p < 0.05). The intervention group showed significantly higher scores in gingival index (p = 0.021) and plaque index (p = 0.001) than the control group at T<sub>1</sub>, while only plaque index scores were significantly different between the two groups at T<sub>2</sub> (p < 0.001).</p><p><strong>Conclusion: </strong>The findings demonstrated an effective educational strategy to promote self-efficacy, oral health behaviors, and oral health status in pregnant women.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histochemical Assessment of Cementum and Alveolar Bone in SDT fa/fa Rat Mimicking Type II Diabetes.","authors":"Tomoka Hasegawa, Mako Sakakibara, Xuanyu Liu, Mai Haraguchi-Kitakamae, Weisong Li, Haoyu Wang, Yan Shi, Jiaxin Cui, Hiromi Hongo, Tomomaya Yamamoto, Miki Abe-Takagi, Haruhi Maruoka, Hirofumi Miyaji, Minqi Li, Norio Amizuka","doi":"10.1111/odi.70079","DOIUrl":"https://doi.org/10.1111/odi.70079","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the histopathology of diabetic periodontal tissues, we examined periodontal disease in Torii-Lepr<sup>fa</sup> (SDT fa/fa) rats, mimicking type 2 diabetes.</p><p><strong>Methods: </strong>Forty 30-week-old male SDT fa/fa rats and age-matched Sprague-Dawley (SD) rats were fixed, and the mandibular first molars and their periodontal tissues were histochemically examined.</p><p><strong>Results: </strong>SDT fa/fa rats exhibited epithelial downgrowth in the previous region of interradicular/interalveolar septa and periodontal spaces. Many osteoclasts and osteoblasts were present on the alveolar bone, indicating high bone turnover. Masses of bacteria were predominantly observed in the necrotic dental pulps and the cementum, where most cementocytic lacunae were empty. The cementum of the SDT fa/fa rats showed a distinct immunolocalization of osteocalcin, osteopontin, and dentin matrix protein-1 compared with the SD rats, but did not show advanced glycation end products, which were instead detected in some blood vessels and interstitial fibrous tissues associated with the down-growing epithelium.</p><p><strong>Conclusions: </strong>SDT fa/fa rats exhibited necrosis of dental pulp and severe periodontitis featuring markedly diminished alveolar bone because of stimulated bone resorption and formation. In addition, dead cementum may serve as bacterial nests, leading to changes in the localization of cementum matrix proteins.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-08-31DOI: 10.1111/odi.70084
Vandana Gupta, Anika Dawar, Sumit Kumar Das, Vikender Singh Yadav, Vanshita Nalwa, Razia Haidrus, Bharathi M Purohit, Lata Goyal
{"title":"Cardiovascular Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Vandana Gupta, Anika Dawar, Sumit Kumar Das, Vikender Singh Yadav, Vanshita Nalwa, Razia Haidrus, Bharathi M Purohit, Lata Goyal","doi":"10.1111/odi.70084","DOIUrl":"https://doi.org/10.1111/odi.70084","url":null,"abstract":"<p><strong>Aim: </strong>This review aimed to synthesize evidence on cardiovascular biomarkers associated with periodontitis, identified in biofluids such as blood, saliva, and gingival crevicular fluid (GCF).</p><p><strong>Methods: </strong>A comprehensive search of five databases was conducted to identify studies comparing cardiovascular biomarker levels in periodontitis and healthy individuals, up to 31 December 2024. Meta-analysis included biomarkers from ≥ 2 studies per biofluid, with sensitivity analysis performed and evidence certainty assessed using the GRADE tool.</p><p><strong>Results: </strong>Thirty-six studies were included in the systematic review, with 31 eligible for meta-analysis. Overall, 39 biomarkers were identified: 33 in blood, 14 in saliva, and 6 in GCF. A meta-analysis was conducted for 12 blood biomarkers, of which high-density lipoprotein (HDL) was significantly reduced, low-density lipoprotein (LDL) was higher in periodontitis (though LDL lost significance on sensitivity analysis), and the oxidative stress index (OSI) was significantly associated with periodontitis. No significant differences were observed for C-reactive protein (CRP), interleukin-1beta (IL-1ß), interleukin (IL)-6, N-terminal pro-B-type natriuretic peptide (NT-proBNP), monocyte chemoattractant protein-1 (MCP-1), and asymmetric dimethylarginine (ADMA). CRP was the only biomarker pooled for saliva and GCF, with no significant findings.</p><p><strong>Conclusion: </strong>Reduced blood HDL and elevated OSI represent potential cardiovascular biomarkers for periodontitis, although the certainty of evidence remains low.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}