Oral diseases最新文献

Comment on "Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches". 对“口服无烟草尼古丁袋使用者的口腔病变和牙齿状况”的评论。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70490

Mariam Amjad, Muhammad Faizan Khan

引用次数: 0

Authors' Reply "Imaging and Pathology Concordance in Head and Neck Cancer: Retrospective Analysis". 作者回复“头颈部肿瘤影像学与病理一致性：回顾性分析”。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70485

Bo Lin, Feng Wang, Shiyue Shen, Yufan Wang, Xia Hong, Xin Ye, Shunji Wang, Youdan Yao, Tianwen Zhang, Huijun Yang, Hongyu Yang

引用次数: 0

Comment on "Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches". 对“口服无烟草尼古丁袋使用者的口腔病变和牙齿状况”的评论。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70489

Giusy Rita Maria La Rosa, Gaetano Isola, Riccardo Polosa

引用次数: 0

Oral Dysbiosis and Malignant Transformation of Oral Potentially Malignant Disorders: The Missing LPS-VEGF Link. 口腔生态失调和口腔潜在恶性疾病的恶性转化：缺失的LPS-VEGF联系。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70487

Lucas Alves da Mota Santana, Michelly Kierkigard Campos de Oliveira, Carlos Eduardo Palanch Repeke, Lysandro Pinto Borges, Wilton Mitsunari Takeshita, Gina Délia Roque-Torres

引用次数: 0

Hormone Replacement Therapy and Periodontitis in Postmenopausal Women: An Updated Systematic Review. 激素替代疗法和绝经后妇女牙周炎：最新的系统综述。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70463

Shahen Hiwa Omer, Mohammed Khalid Mahmood, Yad Mariwan Mohammed Amin, Florence Carrouel, Romain Lan

引用次数: 0

A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma. 脂质代谢相关基因标记对头颈部鳞状细胞癌的预后分层并反映代谢-免疫异质性。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70482

Ting-Zhi Xie, Xin-Yi Sun, Jing Wang, Zhi Wang, Ning Du, Xi-Yuan Ge

{"title":"A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma.","authors":"Ting-Zhi Xie, Xin-Yi Sun, Jing Wang, Zhi Wang, Ning Du, Xi-Yuan Ge","doi":"10.1111/odi.70482","DOIUrl":"https://doi.org/10.1111/odi.70482","url":null,"abstract":"Objective: Lipid metabolism-related genes (LMRGs) are crucial in head and neck squamous cell carcinoma (HNSCC) progression. This study aimed to construct and validate a prognostic model for HNSCC based on LMRGs.Methods: Prognostic LMRGs were screened by analyzing RNA sequencing and clinical data from TCGA and GEO databases, and a prognostic model was constructed. Patients were divided into high- and low-risk groups according to the risk score. Further enrichment analysis, tumor microenvironment (TME) analysis, drug sensitivity analysis, and in vitro validation were performed.Results: Eleven LMRGs (PER2, CTLA4, EPHX3, ABCB1, ANO1, TRIB3, PTX3, OLR1, DKK1, FABP4, and CDKN2A) were identified. Patients in the high-risk group had worse survival, and the risk score was an independent prognostic factor. A nomogram combining risk score and clinical characteristics accurately predicted survival. TME analysis revealed immune dysregulation in the high-risk group. Drug sensitivity analysis showed that the high-risk group was more sensitive to lovastatin. In vitro, lovastatin suppressed malignant behaviors and induced a transcriptomic shift toward a low-risk signature.Conclusion: The results validate the biological significance of the model, highlight potential associations between lipid metabolism and the immune microenvironment in HNSCC, and provide a theoretical basis for further investigating metabolism-related therapeutic strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are We Asking About Tirzepatide? Emerging Oral Health Implications for Oral Medicine Practice. 我们问的是替西帕肽吗？口腔医学实践对口腔健康的影响。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-04 DOI: 10.1111/odi.70484

Diogo de Azevedo Miranda, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade

引用次数: 0

Atopic Dermatitis and Periodontitis: Emerging Population-Based Data. 特应性皮炎和牙周炎：新兴的基于人群的数据。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-02 DOI: 10.1111/odi.70474

Mohammed Taib Fatih, Mohammed Khalid Mahmood, Yad Mariwan Mohammed Amin, Florence Carrouel, Romain Lan

引用次数: 0

Intratumoral Administration of Recombinant Murine Interleukin-12 Prevents Tumor Progression and Bone Invasion. 肿瘤内给药重组小鼠白细胞介素-12阻止肿瘤进展和骨侵袭。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-02 DOI: 10.1111/odi.70399

Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi

{"title":"Intratumoral Administration of Recombinant Murine Interleukin-12 Prevents Tumor Progression and Bone Invasion.","authors":"Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi","doi":"10.1111/odi.70399","DOIUrl":"https://doi.org/10.1111/odi.70399","url":null,"abstract":"Objective: Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin-12 (IL-12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion.Methods: The effects of IL-12 on tumor growth and bone resorption were evaluated using subcutaneous and bone invasion models of OSCC in both immunocompetent and athymic mice. Bone resorption was assessed by micro-computed tomography (CT). In addition, quantitative polymerase chain reaction (qPCR) was performed to quantify the expression of osteoclast markers (Acp5, Ctsk) and immune-related genes (Ifng, Fasl).Results: Intratumoral injection of recombinant murine IL-12 (r-mIL-12) significantly prolonged mouse survival and suppressed tumor growth in immunocompetent mice. Micro-CT revealed reduced bone resorption in the r-mIL-12-treated group. Consistently, qPCR demonstrated downregulation of Acp5 and Ctsk, along with upregulation of Ifng and Fasl compared to controls. In contrast, r-mIL-12 treatment had no significant effect on tumor growth or bone resorption in athymic mice, underscoring the importance of T cells in controlling bone invasion.Conclusions: These findings suggest that local administration of r-mIL-12 may serve as an effective therapeutic approach for OSCC with mandibular bone invasion.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Medicine Under Review: Current Practices and Future Pathways for Specialty Recognition. 口腔医学回顾：目前的实践和未来的专业认可途径。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-31 DOI: 10.1111/odi.70382

N G Nikitakis, M Georgaki, E Piperi, A Vissink, I Alajbeg, I von Bültzingslöwen, B Carey, S Kantola, A R Kerr, N Yarom, M Carrozzo, M Escudier, M D Mignogna, M Meleti, K Delli

引用次数: 0