Oral diseases最新文献

{"title":"Tooth Anomalies in Patients With Nonsyndromic Orofacial Cleft: A Systematic Review and Meta-Analysis.","authors":"Sara Garcia Azevedo, Lilianny Querino Rocha de Oliveira, Hercílio Martelli-Júnior, Ricardo D Coletta, Renato Assis Machado","doi":"10.1111/odi.15226","DOIUrl":"https://doi.org/10.1111/odi.15226","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the frequency of tooth anomalies (TA) in the deciduous and permanent dentition of patients with nonsyndromic orofacial clefts (NSOC), both inside and outside the cleft area.</p><p><strong>Methods: </strong>The following databases were searched for the relevant literature: Cochrane, OVID, SciELO, Embase, Livivo, PubMed, Scopus, and Web of Science. The risk of bias was analyzed using the Joanna Briggs Institute. Fixed and random-effects meta-analysis was performed comparing the presence and absence of NSOC subtypes. The certainty of evidence was evaluated using the GRADE approach.</p><p><strong>Results: </strong>Out of 1939 articles identified, after applying the inclusion and exclusion criteria, a total of 75 articles were included (46 cohort and 29 case-control), including 27,703 patients (16,450 with NSOC and 11,253 healthy controls) from 34 countries. The meta-analyses revealed higher odds for tooth agenesis (OR<sub>NSOC</sub>: 3.72; p = 0.001) and macrodontia (OR<sub>NSOC</sub>: 8.04; p = 0.04) across the different cleft subtypes outside the cleft area compared with the control group in the permanent dentition, whereas the frequency of root dilaceration was significantly lower in nonsyndromic cleft lip only (NSCLO) (OR<sub>NSCLO</sub>: 0.38; p < 0.0001) and in nonsyndromic cleft lip and palate (NSCLP) (OR<sub>NSCLP</sub>: 0.44; 95% p < 0.0001). The results also demonstrated a higher risk of tooth agenesis (OR<sub>NSOC</sub>: 16.49; p < 0.0001), microdontia (OR<sub>NSOC</sub>: 17.14; p < 0.0001), macrodontia (OR<sub>NSOC</sub>: 10.41; p = 0.02), supernumerary tooth (OR<sub>NSOC</sub>: 10.03; p < 0.0001), and enamel hypoplasia (OR<sub>NSOC</sub>: 5.62; p < 0.0001) in the permanent dentition inside the cleft area of patients with NSOC. However, for the deciduous dentition, outside the cleft area, microdontia was the only TA significantly more frequent in patients with NSOC (OR<sub>NSOC</sub>: 6.24; p = 0.006) and nonsyndromic cleft palate only (NSCPO) (OR<sub>NSCPO</sub>: 8.45; p = 0.02) compared with the control group. TA associations varied across populations. In Europe, no significant associations were found for NSOC, while in Asia, strong associations were observed for NSCLP and NSCL ± P (OR<sub>NSCLP and NSCL±P</sub>: 139.19; p < 0.0001). In South America, significant associations were identified for NSCLP (OR<sub>NSCLP</sub>: 2.16; p < 0.0001), NSCL ± P (OR<sub>NSCL±P</sub>: 2.48; p < 0.0001), and NSOC (OR<sub>NSOC</sub>: 2.72; p < 0.0001). In North America, tooth agenesis was more frequent in NSCL ± P (OR<sub>NSCL±P</sub>: 4.75; p < 0.0001), though no significant associations were found for NSCLP or NSOC. In the cleft area, significant associations were observed in European populations for NSOC, including increased frequencies of tooth agenesis (OR<sub>NSOC</sub>: 19.57; p = 0.003) and supernumerary teeth (OR<sub>NSOC</sub>: 9.77; p < 0.0001). Asian populations showed similar patterns (OR<sub>NSOC","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of OLP and OLL: Demographic and Clinical Profile in a Reference Center in Brazil.","authors":"Thales Felipe Dos Santos de Oliveira, Michelle Roxo Gonçalves, Marco Antonio Trevizani Martins, Manoela Domingues Martins, Lorenzo Lo Muzio, Fernanda Visioli, Vinicius Coelho Carrard","doi":"10.1111/odi.15247","DOIUrl":"https://doi.org/10.1111/odi.15247","url":null,"abstract":"<p><strong>Objective: </strong>To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.</p><p><strong>Methods: </strong>This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features. Categorical and numerical variables were analyzed using chi-square and Mann-Whitney tests (p < 0.01), respectively.</p><p><strong>Results: </strong>Applying strict diagnostic criteria, 29% (n = 34) of cases were classified as OLP and 71% (n = 83) as OLL. OLP cases had mainly multifocal manifestations (82.4%), exhibiting a reticular pattern (100%) and primarily occurring on the buccal mucosa (94.1%). Conversely, OLL cases presented both unilateral (48.2%) and multifocal (51.8%) distributions, with a predominantly atrophic-erosive pattern (77.1%) and higher occurrence on the buccal mucosa (69.9%) and tongue (48.2%). OLL patients reported a higher frequency of systemic disorders and medication use (p < 0.01). Hypertension was the most prevalent condition, leading to the frequent use of cardiovascular medications. Two OLL cases without initial dysplasia underwent malignant transformation.</p><p><strong>Conclusion: </strong>Patient profiles and clinical manifestations of the entities were similar, highlighting the utility of a differential diagnosis, particularly given the apparent association between malignant transformation and OLL cases.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoledronic Acid Regulates Osteoclasts via miR-483-5p in the BRONJ.","authors":"Zhiyong Guo, Jiajin Yang, Chunjie Li, Xiufa Tang, Jiyuan Liu","doi":"10.1111/odi.15233","DOIUrl":"https://doi.org/10.1111/odi.15233","url":null,"abstract":"<p><strong>Objectives: </strong>Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of bisphosphonate therapy, with unclear mechanisms. This study investigates the regulatory impact of zoledronic acid (ZOL) on osteoclasts and microRNA (miRNA) expression.</p><p><strong>Materials and methods: </strong>Raw264.7 cells and bone marrow-derived macrophages (BMMs) were used to assess ZOL's effects on proliferation and apoptosis. miRNA array analysis was performed during osteoclastogenesis with ZOL treatment. The role of miR-483-5p was examined using miR-mimics and miR-inhibitors. A rat BRONJ model was established for in vivo validation.</p><p><strong>Results: </strong>A concentration of 2 μM ZOL, which did not affect cell proliferation or apoptosis, was used in subsequent experiments. ZOL altered the expression of 64 miRNAs (39 upregulated, 25 downregulated). miR-483-5p mimics alleviated ZOL-induced inhibition of osteoclastogenesis, actin ring formation, bone resorption, and differentiation marker expression, whereas inhibitors enhanced these effects. In vivo, Ago-miR-483-5p promoted wound healing in the BRONJ model, while Antago-miR-483-5p impaired it.</p><p><strong>Conclusions: </strong>ZOL modulates osteoclast function in BRONJ through miR-483-5p inhibition. miR-483-5p may serve as a novel therapeutic target for BRONJ treatment, providing new insights into managing this complication.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Correlation Between Quality of Life and Salivary Interleukin-6 in Patients With Oral Lichen Planus or Burning Mouth Syndrome?","authors":"Ana Glavina, Liborija Lugović-Mihić, Dinko Martinović, Livia Cigić, Dolores Biočina-Lukenda, Daniela Šupe-Domić","doi":"10.1111/odi.15249","DOIUrl":"https://doi.org/10.1111/odi.15249","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).</p><p><strong>Materials and methods: </strong>A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs). QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14).</p><p><strong>Results: </strong>The salivary IL-6 concentration showed no statistically significant difference between patients with OLP, patients with BMS or control subjects (p = 0.244). There was a strong/good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension \"physical pain\" (r = 0.720, p < 0.001) and \"physical impossibility\" (r = 0.372, p = 0.003) in patients with OLP. There was a good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension \"handicap\" (r = 0.353, p = 0.005) in patients with BMS.</p><p><strong>Conclusions: </strong>Symptom intensity (pain/burning) showed no correlation with salivary IL-6 concentration in patients with OLP or BMS. A slight increase or decrease in salivary IL-6 concentration in OLP or BMS indicates an inflammatory etiopathogenesis of OLP and a loss of neuroprotection in BMS.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study.","authors":"Valentin Bartha, Sébastien Boutin, Dorothée L Schüßler, Anna Felten, Shila Fazeli, Florentina Kosely, Thomas Luft, Diana Wolff, Cornelia Frese, Kyrill Schoilew","doi":"10.1111/odi.15246","DOIUrl":"https://doi.org/10.1111/odi.15246","url":null,"abstract":"<p><strong>Aim: </strong>Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT).</p><p><strong>Materials and methods: </strong>Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated.</p><p><strong>Results: </strong>Ten of 25 included patients developed ulcerations. The α-diversity decreased between T0 and T1, independent of ulcerations. PERMANOVA revealed differences in beta diversity between T1 stool samples from patients with and without ulcerations. At T1, saliva samples of patients with ulcerations showed an increase of Mycoplasma salvarius, while commensals decreased in saliva and mucosal swabs. The gut microbiome of both groups showed an overabundance of Enterococcus spp., associated with inflammatory conditions. Salival α-diversity of older and overweight patients decreased slower, whereas in mucosal swabs mucositis or impaired renal function was associated with a higher decline. Female gender and history of periodontitis were associated with increased stool microbiome changes, while self-reported probiotics intake was related to reduced changes.</p><p><strong>Conclusions: </strong>Ulcerations appeared in 40% of the patients. Distinct microbial changes, including increased abundance of Mycoplasma salivarius in saliva and decreased abundance of commensals, marked those with ulcerations.</p><p><strong>Trial registration: </strong>The study was registered in the German Register for Clinical Studies (DRKS00032882).</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestations of Head and Neck Cancer in Patients With Plummer-Vinson Syndrome: A Systematic Review.","authors":"Brunno Santos de Freitas Silva, Débora Peclat Souza, Alessah Carolyna de Andrade Fernandes, Larissa Rosa Santana Rodrigues, Omar Kujan, Fernanda Paula Yamamoto-Silva","doi":"10.1111/odi.15224","DOIUrl":"https://doi.org/10.1111/odi.15224","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical manifestations of head and neck cancer in patients with Plummer-Vinson syndrome (PVS) and to assess related oral comorbidities.</p><p><strong>Materials and methods: </strong>Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two-phase selection process.</p><p><strong>Results: </strong>Out of a total of 19,183 citations identified, seven met the inclusion criteria. Prevalent symptoms included dysphagia and esophageal webs, with atrophic glossitis and angular cheilitis being common oral manifestations. Most patients presented with long-standing iron deficiency anemia. Head and neck cancers predominantly affected the pharynx and tongue borders, with younger age groups notably affected. The overall risk of bias attributable to the quality of the reports was assessed as \"low\".</p><p><strong>Conclusions: </strong>Despite the rarity of PVS-related head and neck cancer, this review underscores its association, particularly in younger patients. A thorough examination of dysphagia and oral manifestations in PVS patients is crucial for early detection and prevention of head and neck cancer.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones.","authors":"Liu-Yang Qu, Dan-Ni Zheng, Xiao-Tong Ling, Guan-Qi Liu, Xiao-Yun Xu, Deng-Gao Liu","doi":"10.1111/odi.15234","DOIUrl":"https://doi.org/10.1111/odi.15234","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the microarchitecture and crystalline composition of sialoliths and to explore their formation mechanisms.</p><p><strong>Methods: </strong>Sixty-six sialolith samples (51 from the submandibular glands and 15 from the parotid glands) were retrospectively collected. Their diameter and quality were measured. Micro-computed tomography, scanning electron microscopy, and polycrystalline X-ray diffractometer (XRD) were utilized to determine their microstructure and crystalline composition.</p><p><strong>Results: </strong>Stone diameter and weight averaged at 9.6 mm and 0.31 g, respectively. Submandibular stones showed larger size and weight than parotid stones. Microstructurally, the main stones were concentric (n = 51) or mixed (n = 15). Most concentric stones occurred at submandibular glands, while 80% of the mixed stones were parotid stones. Stone surface exhibited three microscopic structures: lamellar, grape-like, and porous, indicating their differences in mineralization process and composition. XRD revealed that all stones contained hydroxyapatite, with 57 containing whitlockite. Concentration of hydroxyapatite in concentric stones was significantly higher than that in mixed stones (p = 0.036) and correlated positively with stone diameter (p = 0.001). The microstructure and crystalline composition of multiple and recurrent stones were similar to that of single stones.</p><p><strong>Conclusion: </strong>Sialoliths display pronounced diversity in microarchitecture and crystalline composition, reflecting the differences in mineralization process and local microenvironments among stones.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LepR-Expressing Cells in Bone and Periodontium.","authors":"Yue Li, Peitong Li, Kun Xue, Peilei Shi, Xudong Xie, Jun Wang, Chunmei Xu","doi":"10.1111/odi.15211","DOIUrl":"https://doi.org/10.1111/odi.15211","url":null,"abstract":"<p><strong>Objective: </strong>LepR-expressing cells (LepR⁺ cells), a critical subpopulation of mesenchymal stem cells, have gained increasing attention in the last decade. LepR⁺ cells have been found to play a crucial role in maintaining bone and periodontal homeostasis. This review summarizes current research advances focusing on the role of LepR⁺ cells and their underlying regulatory molecular mechanisms in bones and periodontium, aiming to provide a better understanding of the therapeutic potential of this cell lineage.</p><p><strong>Methods: </strong>A literature review was conducted based on publications in PubMed over the past 20 years, summarizing the research progress on LepR⁺ cells in bone and periodontal tissues.</p><p><strong>Results: </strong>Current evidence revealed that LepR⁺ cells possess the ability of self-renewal and multilineage differentiation and are essential for bone turnover and periodontal tissue remodeling. In addition, LepR⁺ cells participate in the processes of bone fracture healing and alveolar socket healing. Moreover, under pathological conditions such as osteoporosis, bone marrow fibrosis, and periodontitis, LepR⁺ cells exhibit enhanced adipogenic or fibrogenic differentiation abilities.</p><p><strong>Conclusion: </strong>Therapeutic approaches targeting the cell fate of LepR⁺ cells hold the potential to provide novel insights into bone/periodontal repair and regeneration therapy.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of PAX1 in OSCC Enhances Stemness and Immunosuppression via IFIT1 and PD-L1 Pathways.","authors":"Hui-Hsin Ko, Hsin-Hui Peng, Han-Yi E Chou, Hsin-Han Hou, Wei-Wen Liu, Mark Yen-Ping Kuo, Alan Yueh-Luen Lee, Hsiang-Fong Kao, Hung-Ying Lin, Ying-Chieh Chang, Wei-Ting Kuo, Shih-Jung Cheng","doi":"10.1111/odi.15225","DOIUrl":"https://doi.org/10.1111/odi.15225","url":null,"abstract":"<p><strong>Objective: </strong>Our study investigated how arecoline-induced extracellular vesicle (EV) secretion suppresses PAX1 protein production through DNA hypermethylation and examined whether PAX1 downregulation enhances cancer stemness and immunosuppression in the tumor microenvironment.</p><p><strong>Materials and methods: </strong>EVs were isolated from SAS/TW2.6 cancer cell lines using ultracentrifugation and identified using transmission electron microscopy. PAX1 DNA methylation was tested in an ISO17025-certified lab, with and without EV pretreatment. Stemness and epithelial-mesenchymal transition markers were assessed by western blotting and 3D culture. PAX1, IFIT1, and PD-L1 co-expression were examined through immunofluorescence. Flow cytometry detected various T cells.</p><p><strong>Results: </strong>Arecoline-induced EVs enhanced PAX1 methylation, suppressing its tumor-suppressive function. Reduced PAX1 mRNA in OSCCs was linked to larger tumors, nodal metastasis, late-stage disease, areca quid chewing, and poor survival. Downregulated PAX1 protein negatively correlated with IFIT1 and PD-L1 expression. Reduced PAX1 promoted stemness via the IFIT1 pathway, increasing PD-L1 secretion and aiding immune evasion. PD-L1 expression correlated with Treg and CD8+ T cell levels in OSCC tissues, and the CD4+/CD8+ T cell ratio was lower in OSCC patients than in controls.</p><p><strong>Conclusion: </strong>Arecoline-induced EV production, which influences PAX1/IFIT1/PD-L1 function, may serve as a reliable biomarker for targeted therapy in OSCC patients.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits.","authors":"Siwei Xu, Kaixin Yan, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu","doi":"10.1111/odi.15238","DOIUrl":"https://doi.org/10.1111/odi.15238","url":null,"abstract":"<p><strong>Background: </strong>The treatment procedure for intracapsular condylar fractures (ICF) is still being debated. The temporomandibular joint (TMJ) disc is a key factor for treating ICF. The study aims to investigate the changes in TMJ disc status and condylar cartilage regeneration following ICF in a rabbit model, to assist in planning treatment.</p><p><strong>Methods: </strong>Adolescent and adult rabbits received surgery on the left TMJs: (1) ICF with anterior disc displacement, (2) ICF with the removal of the ICF segment and disc. The animals were euthanized immediately, and at 4, 8, and 12 weeks after surgery. Their left TMJs were collected for histological, SOX 9 immunohistochemical, and micro-CT analyses.</p><p><strong>Results: </strong>All 36 TMJs (100%) showed anterior disc displacement at 4, 8, and 12 weeks after surgery. Also, condylar cartilage regeneration was observed in all 36 joints. Notably, partial regeneration of condylar cartilage was noted at 4 weeks after removal of the disc and ICF fractured segment in both adolescent and adult groups.</p><p><strong>Conclusion: </strong>Anterior displaced disc after ICF in adolescent and adult rabbits exhibited sustained disc displacement without therapeutic intervention. TMJ disc and associated attachment are crucial in the condylar cartilage regeneration after ICF.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}