{"title":"口腔黏膜黑色素瘤的预后预测因素：系统回顾和荟萃分析。","authors":"Sofia Sebastian, Monal Yuwanati, Pratibha Ramani","doi":"10.1111/odi.70105","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oral mucosal melanoma (OMM) is a rare, aggressive malignancy; however, prognostic factors for OMM remain poorly defined. This systematic review and meta-analysis aimed to identify prognostic predictors that influence survival outcomes in OMM patients.</p><p><strong>Methods: </strong>PubMed, Web of Science, and Scopus were searched for case reports, case series, and retrospective observational studies involving patients with OMM. Data on demographics, tumor features, and survival were extracted. Meta-analysis was performed using a random-effects model. Study quality was assessed using Murad criteria and the JBI checklist.</p><p><strong>Results: </strong>A total of 16 studies comprising 1151 patients were included in the systematic review; five studies with 942 patients were included in the meta-analysis. The pooled 5-year survival proportion was 34% (95% CI: 24%-45%, I<sup>2</sup> = 87%). Key predictors of poor prognosis included tumor size > 4 cm, lymph node metastasis, and non-palatal tumor location. Palatal lesions showed better survival (2-year survival-85%). Treatment primarily involved surgical resection; adjuvant therapies had limited benefit. Neck dissection showed no consistent survival advantage.</p><p><strong>Conclusions: </strong>Tumor size, lymph node involvement, and anatomical site are significant prognostic indicators in OMM. Standardized staging systems incorporating tumor burden and histopathologic markers are essential for improved prognostication.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic Predictors of Oral Mucosal Melanoma-A Systematic Review and Meta-Analysis.\",\"authors\":\"Sofia Sebastian, Monal Yuwanati, Pratibha Ramani\",\"doi\":\"10.1111/odi.70105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oral mucosal melanoma (OMM) is a rare, aggressive malignancy; however, prognostic factors for OMM remain poorly defined. This systematic review and meta-analysis aimed to identify prognostic predictors that influence survival outcomes in OMM patients.</p><p><strong>Methods: </strong>PubMed, Web of Science, and Scopus were searched for case reports, case series, and retrospective observational studies involving patients with OMM. Data on demographics, tumor features, and survival were extracted. Meta-analysis was performed using a random-effects model. Study quality was assessed using Murad criteria and the JBI checklist.</p><p><strong>Results: </strong>A total of 16 studies comprising 1151 patients were included in the systematic review; five studies with 942 patients were included in the meta-analysis. The pooled 5-year survival proportion was 34% (95% CI: 24%-45%, I<sup>2</sup> = 87%). Key predictors of poor prognosis included tumor size > 4 cm, lymph node metastasis, and non-palatal tumor location. Palatal lesions showed better survival (2-year survival-85%). Treatment primarily involved surgical resection; adjuvant therapies had limited benefit. Neck dissection showed no consistent survival advantage.</p><p><strong>Conclusions: </strong>Tumor size, lymph node involvement, and anatomical site are significant prognostic indicators in OMM. Standardized staging systems incorporating tumor burden and histopathologic markers are essential for improved prognostication.</p>\",\"PeriodicalId\":19615,\"journal\":{\"name\":\"Oral diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/odi.70105\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.70105","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
背景：口腔黏膜黑色素瘤是一种罕见的侵袭性恶性肿瘤；然而，OMM的预后因素仍然不明确。本系统综述和荟萃分析旨在确定影响OMM患者生存结果的预后预测因素。方法：检索PubMed、Web of Science和Scopus中涉及OMM患者的病例报告、病例系列和回顾性观察性研究。提取了人口统计学、肿瘤特征和生存率的数据。采用随机效应模型进行meta分析。采用Murad标准和JBI检查表评估研究质量。结果：系统评价共纳入16项研究，1151例患者；荟萃分析纳入了5项研究，共942例患者。合并5年生存率为34% （95% CI: 24%-45%, I2 = 87%）。预后不良的主要预测因素包括肿瘤大小bbb4cm、淋巴结转移和非腭部肿瘤位置。腭部病变患者生存率较高（2年生存率为85%）。治疗主要包括手术切除；辅助治疗的效果有限。颈部清扫没有一致的生存优势。结论：肿瘤大小、淋巴结受累程度和解剖部位是OMM预后的重要指标。结合肿瘤负荷和组织病理学标志物的标准化分期系统对于改善预后至关重要。
Prognostic Predictors of Oral Mucosal Melanoma-A Systematic Review and Meta-Analysis.
Background: Oral mucosal melanoma (OMM) is a rare, aggressive malignancy; however, prognostic factors for OMM remain poorly defined. This systematic review and meta-analysis aimed to identify prognostic predictors that influence survival outcomes in OMM patients.
Methods: PubMed, Web of Science, and Scopus were searched for case reports, case series, and retrospective observational studies involving patients with OMM. Data on demographics, tumor features, and survival were extracted. Meta-analysis was performed using a random-effects model. Study quality was assessed using Murad criteria and the JBI checklist.
Results: A total of 16 studies comprising 1151 patients were included in the systematic review; five studies with 942 patients were included in the meta-analysis. The pooled 5-year survival proportion was 34% (95% CI: 24%-45%, I2 = 87%). Key predictors of poor prognosis included tumor size > 4 cm, lymph node metastasis, and non-palatal tumor location. Palatal lesions showed better survival (2-year survival-85%). Treatment primarily involved surgical resection; adjuvant therapies had limited benefit. Neck dissection showed no consistent survival advantage.
Conclusions: Tumor size, lymph node involvement, and anatomical site are significant prognostic indicators in OMM. Standardized staging systems incorporating tumor burden and histopathologic markers are essential for improved prognostication.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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