Epidemiology and Prognosis of Ameloblastic Carcinoma: A 20-Year Single-Center Retrospective Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-09-30 DOI:10.1111/odi.70108

Zi-Han Dang, Tao-Min Zhu, Xin-Yu Dou, Chun-Yu Feng, Zi-Han Jiang, Si-Jie Yang, Er-Hui Jiang, Zheng-Jun Shang

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引用次数: 0

Abstract

Backgrounds: Ameloblastic carcinoma, a rare malignant odontogenic tumor, is difficult to diagnosis and treat. Here, we retrospectively analyzed its epidemiology, prognosis, and atypical ameloblastoma, a lesion insufficient to diagnose as ameloblastic carcinoma, to provide insights for understanding.

Methods: This study included 23 cases of ameloblastic carcinoma and 31 of atypical ameloblastoma from 2004 to 2024. Epidemiology, clinical symptoms, radiographic features, treatment, and prognosis were analyzed.

Results: Regarding ameloblastic carcinoma, 15 males and 8 females ranging from 21 to 85 years old were included, with an average of 51.57. Eleven cases (47.8%) occurred in the maxilla. The main symptom was swelling, and the radiographic features included honeycomb-like features. The prognosis was revealed during the 1- to 19-year follow-up; 11 patients did not experience recurrence, 4 experienced recurrence, 7 died, and 1 was missing. The prognosis analysis revealed site, type and therapy without flap repair might be associated with recurrence, suggesting prompt extended resection might be the preferred treatment. Among patients with atypical ameloblastoma, 2 patients subsequently developed ameloblastic carcinoma, and 5 experienced recurrence.

Conclusion: Ameloblastic carcinoma, a rare malignant tumor with high recurrence and mortality rates, and atypical ameloblastoma with a potential for malignancy should receive prompt treatment and rigorous follow-up.

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成釉细胞癌的流行病学和预后：一项20年单中心回顾性研究。

背景：成釉细胞癌是一种罕见的牙源性恶性肿瘤，诊断和治疗困难。在此，我们回顾性分析其流行病学，预后和非典型成釉细胞瘤，这种病变不足以诊断为成釉细胞癌，以提供理解的见解。方法：对2004 ~ 2024年收治的23例成釉细胞癌和31例不典型成釉细胞瘤进行回顾性分析。分析流行病学、临床症状、影像学特征、治疗及预后。结果：成釉细胞癌男性15例，女性8例，年龄21 ~ 85岁，平均51.57例。11例（47.8%）发生在上颌骨。主要症状为肿胀，影像学表现为蜂窝状征象。随访1 ~ 19年，观察预后；未复发11例，复发4例，死亡7例，失踪1例。预后分析显示，不进行皮瓣修复的部位、类型和治疗可能与复发有关，提示及时延长切除可能是首选的治疗方法。非典型成釉细胞瘤2例发展为成釉细胞癌，5例复发。结论：成釉细胞癌是一种罕见的恶性肿瘤，复发率高，死亡率高，不典型成釉细胞瘤有恶性发展的可能，应及时治疗，严密随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.