Oral diseases最新文献_第2页

Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review. 口腔慢性炎症性粘膜疾病的黏附给药系统。未来已经存在。系统评价。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-23 DOI: 10.1111/odi.70042

M E Mauceri, M Coppini, V De Caro, G Di Prima, R Mauceri, V Panzarella, G Giuliana, G Campisi

{"title":"Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review.","authors":"M E Mauceri, M Coppini, V De Caro, G Di Prima, R Mauceri, V Panzarella, G Giuliana, G Campisi","doi":"10.1111/odi.70042","DOIUrl":"https://doi.org/10.1111/odi.70042","url":null,"abstract":"Background: Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are considered the most painful oral inflammatory diseases, with high global prevalence and significant impacts on patients' quality of life. In the last decades, researchers have been exploring mucoadhesive drug delivery systems (MDDS) to improve drugs safety and efficacy through optimized formulations for enhancing patients compliance while addressing the limitations of semisolid products.Objective: To assess the clinical efficacy of different MDDS (e.g., tablets, films, and patches) in treating OLP or RAS by a revision of the literature.Methods: According to PRISMA guidelines, the study assessed the remission of signs and symptoms in terms of decreasing burning sensation, pain severity, and lesion size. The protocol was registered on the PROSPERO database (CRD42024603173) and records identified by Medline/PubMed/Scopus.Results: Thirteen observational studies involving humans affected by OLP or RAS were included. The absence of standardized therapies in terms of MDDS, drug, and dosing regimen was highlighted. All MDDS offered several benefits, including prolonged drug release, protection from mechanical irritation, and pain and inflammation reduction. MDDS improved patients' adherence by minimizing daily applications and systemic side effects.Conclusions: MDDS may represent a promising option for both OLP and RAS treatments, addressing key limitations of traditional formulations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder. 颞下颌紊乱患者的牵涉性疼痛表现及其影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-21 DOI: 10.1111/odi.70021

Beatriz Amaral de Lima-Netto, Paulo César Rodrigues Conti, Rafaela Stocker Salbego, Matheus Herreira-Ferreira, Yuri Martins Costa, Leonardo Rigoldi Bonjardim

{"title":"Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder.","authors":"Beatriz Amaral de Lima-Netto, Paulo César Rodrigues Conti, Rafaela Stocker Salbego, Matheus Herreira-Ferreira, Yuri Martins Costa, Leonardo Rigoldi Bonjardim","doi":"10.1111/odi.70021","DOIUrl":"https://doi.org/10.1111/odi.70021","url":null,"abstract":"Objective: To investigate whether a higher number of sites eliciting referred pain upon palpation is associated with greater impairment in biopsychosocial aspects in TMD patients and identify variables that predict increased referred pain.Methods: This cross-sectional study analyzed data from 77 women with myalgia, assessing the number of sites eliciting referred pain upon palpation in relation to clinical (duration, frequency, intensity, painful body sites, pain-related disability), psychological (stress, anxiety, depression, catastrophizing, sleep quality), and psychophysical variables (mechanical and pressure pain thresholds, temporal summation and conditioned pain modulation).Results: Spearman's correlation revealed a significant correlation between the number of sites eliciting referred pain upon palpation in the orofacial region and both pain intensity and frequency (p < 0.001), as well as with the number of painful body sites (p = 0.009). Negative binomial regression indicated that each additional day of pain in the past week and each additional painful body site were predictors of increases of 10% and 4%, respectively, in the number of sites eliciting referred pain upon palpation.Conclusions: These findings highlight the utility of assessing referred pain sites as a complementary indicator of severity in clinical pain parameters, providing a practical and effective tool for a more comprehensive evaluation of patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment: Association Between Metabolic Syndrome and Salivary MMP-8, Myeloperoxidase in Periodontitis. 评论：代谢综合征与牙周炎患者唾液MMP-8、髓过氧化物酶的关系。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-20 DOI: 10.1111/odi.15305

Juan Zhang, Guohao Xu, Yongmei Li

引用次数: 0

Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review. 口腔鳞状细胞癌患者的生殖系变异：系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-20 DOI: 10.1111/odi.70040

Mateus José Dutra, Lauren Frenzel Schuch, Felippe José Almeida Loureiro, Felipe Martins Silveira, Marcio Ajudarte Lopes, Manoela Domingues Martins, Wilfredo Alejandro González Arriagada, Daniela Adorno Farias, Ricardo Fernández-Ramires, Vivian Petersen Wagner

{"title":"Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.","authors":"Mateus José Dutra, Lauren Frenzel Schuch, Felippe José Almeida Loureiro, Felipe Martins Silveira, Marcio Ajudarte Lopes, Manoela Domingues Martins, Wilfredo Alejandro González Arriagada, Daniela Adorno Farias, Ricardo Fernández-Ramires, Vivian Petersen Wagner","doi":"10.1111/odi.70040","DOIUrl":"https://doi.org/10.1111/odi.70040","url":null,"abstract":"Objective: Integrate studies on germline variations (GV) in patients with oral squamous cell carcinoma (OSCC), aiming to assess the highest frequencies of which genes were altered in patients with this diagnosis.Methods: An electronic search was conducted in four databases and in the gray literature, following the PRISMA 2020 recommendations. Case reports, case series, case-control studies, cross-sectional studies, prospective cohort studies, and retrospective cohort studies reporting GV in patients with OSCC were included for data extraction.Results: Twenty articles were included, covering 146 cases of OSCC. Patients had a mean age of 47.5 years; the majority were male, non-drinkers, and non-smokers. For most cases, p16 staining and human papilloma virus (HPV) status were not investigated/reported. A total of 231 different GV genes were identified in the 146 patients, with the most frequently altered being ND5 (6.1%), CYTB (4.8%), COX1 (4.6%), PDE4DIP (4.1%), ND1 (3.9%), ND4 (3.2%), ND2 (2.7%), ATP6 (2.7%), CDKN2A (2.6%), COX2 (2.4%), COX3 (2.2%), and ND3 and ND6, both accounting for 2% each.Conclusion: This review compiles important data on the most frequent GV in patients with OSCC, enabling new understandings of oral carcinogenesis, as well as future directions for prognosis and treatment.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of PTEN Overexpression Plus Anti-PD-1 on Immune Escape in Oral Squamous Cell Carcinoma. PTEN过表达加抗pd -1对口腔鳞癌免疫逃逸的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-20 DOI: 10.1111/odi.70036

Jiaxin Luo, Yang Yang, Yuanyang Li, Zhuoya Cui, Dan Zhao

{"title":"Effect of PTEN Overexpression Plus Anti-PD-1 on Immune Escape in Oral Squamous Cell Carcinoma.","authors":"Jiaxin Luo, Yang Yang, Yuanyang Li, Zhuoya Cui, Dan Zhao","doi":"10.1111/odi.70036","DOIUrl":"https://doi.org/10.1111/odi.70036","url":null,"abstract":"Objectives: Phosphatase and tensin homolog (PTEN) is an essential regulator of tumor proliferation, apoptosis, and migration. However, the mechanisms by which PTEN regulates immune escape and its implications in immune checkpoint inhibitor combination therapy in oral squamous cell carcinoma (OSCC) remain unclear.Methods: We analyzed the expression of PTEN and PD-L1 in OSCC tissues and cell lines, and their associations with clinicopathological characteristics. The role of PTEN in modulating PD-L1 expression and facilitating tumor immune evasion was investigated using western blotting and T-cell cytotoxicity assays. PTEN regulation efficacy, alone or with immune checkpoint inhibitors, was evaluated in humanized xenograft mice.Results: Reduced PTEN and increased PD-L1 were strongly correlated with high clinical stage, positive lymph node metastasis, and lower CD8+ T-cell infiltration. Patients with lower PTEN, higher PD-L1, higher clinical stage, and positive lymph node metastasis experienced shorter overall survival. PTEN overexpression suppressed PD-L1 levels and promoted cytotoxic T-cell activity in OSCC cells by inhibiting PI3K/AKT signaling in vitro. Upregulating PTEN alone or combined with anti-PD-1 treatment effectively inhibited OSCC tumor progression and promoted CD8+ T-cell infiltration in tumors in vivo.Conclusions: PTEN upregulation enhances the antitumor immune response of CD8+ T-cells, suggesting a potential OSCC immunotherapy strategy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience in Creating a Teleconsultation Service in Oral Medicine in the Jequitinhonha Valley During the COVID-19 Pandemic. 2019冠状病毒病疫情期间杰基廷霍哈河谷建立口腔医学远程会诊服务的经验

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-17 DOI: 10.1111/odi.70034

Moisés Willian Aparecido Gonçalves, Gabriela Fonseca Rocha, Larissa Doalla de Almeida E Silva, João Luiz de Miranda, Jorge Esquiche León, Cássio Roberto Rocha Dos Santos, Ana Terezinha Marques Mesquita

引用次数: 0

Oral Health Implications of Shelled Sunflower Seed Chewing: A Clinical Case Series. 咀嚼带壳葵花籽对口腔健康的影响：一个临床病例系列。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-14 DOI: 10.1111/odi.70033

Suresh Kandagal Veerabhadrappa, Srinivas Sulugodu Ramachandra, Seema Yadav, Xin Yee Lee, Lim Geok Leng

引用次数: 0

Radiographic Analysis of MRONJ in Osteoporotic and Oncologic Patients on Bisphosphonates or Denosumab. 双膦酸盐或地诺单抗治疗的骨质疏松和肿瘤患者MRONJ的影像学分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-14 DOI: 10.1111/odi.70030

Omar Ghanaiem, Gavriel Chaushu, Daya Masri

{"title":"Radiographic Analysis of MRONJ in Osteoporotic and Oncologic Patients on Bisphosphonates or Denosumab.","authors":"Omar Ghanaiem, Gavriel Chaushu, Daya Masri","doi":"10.1111/odi.70030","DOIUrl":"https://doi.org/10.1111/odi.70030","url":null,"abstract":"Introduction: Medication-Related Osteonecrosis of the Jaw (MRONJ) is a severe adverse effect of antiresorptive and antiangiogenic treatment, primarily in osteoporotic and oncologic patients. The disease is characterized by persistent jawbone necrosis that results in significant impairment of the quality of life of involved patients. The aim of this study is to compare the radiographic characteristics of MRONJ between osteoporotic and oncologic patients and assess the differences based on treatment type, particularly bisphosphonates and denosumab (RANK-L inhibitors).Methods: A retrospective analysis of 152 MRONJ patients (41 osteoporotic, 111 oncologic) from Rabin-Bilinson Medical Center (2014-2024) examined radiographic features-lytic changes, sclerosis, periosteal reactions, sequestration, and periodontal ligament destruction-using panoramic radiography, CBCT, and MDCT.Results: Sclerosis was more frequent in osteoporotic patients compared to oncologic patients (p < 0.05). No statistically significant differences were found in other radiographic features. Bisphosphonate-induced MRONJ was more frequently accompanied by sclerosis compared to denosumab-related cases in osteoporotic patients (p = 0.0318), while no significant differences were found in the oncologic group.Conclusions: Most of the radiographic features of MRONJ were similar in osteoporotic and oncologic patients. However, sclerosis was more common in osteoporotic patients exposed to Bisphosphonates, which may be due to their prolonged exposure to antiresorptive drugs.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limosilactobacillus reuteri Improves Healing Following Fully Impacted Tooth Extractions: Randomized Clinical Trial. 罗伊氏乳酸杆菌促进全阻生拔牙后的愈合：随机临床试验。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-13 DOI: 10.1111/odi.70026

Chiara Cinquini, Rossana Izzetti, Marco Nisi, Francesco Gulia, Berta Garcia Mira, Antonio Barone

{"title":"Limosilactobacillus reuteri Improves Healing Following Fully Impacted Tooth Extractions: Randomized Clinical Trial.","authors":"Chiara Cinquini, Rossana Izzetti, Marco Nisi, Francesco Gulia, Berta Garcia Mira, Antonio Barone","doi":"10.1111/odi.70026","DOIUrl":"https://doi.org/10.1111/odi.70026","url":null,"abstract":"Objectives: This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of L. reuteri administration on postsurgical wound healing, pain levels, and patient-reported outcomes (PROs) following extraction of fully impacted teeth.Methods: Consecutive patients requiring surgical extractions were included and randomly allocated to either test (probiotic) or control group (placebo). Following oral hygiene procedures, patients began a daily probiotic/placebo intake 7 days before surgery until 14 days after surgery. Follow-up was performed at 3 (T3), 7 (T7), and 14 (T14) days postop. Wound healing, postoperative complications, pain, perceived functional impairment, and Oral Health Impact Profile-14 (OHIP-14) were registered.Results: A total of 128 patients (67 in the test group and 61 in the control group) were analyzed. Wound healing significantly improved in the test group at T3 and T7. Trismus was significantly milder in the test group at T3 and T14. No differences in pain were noted. The test group experienced reduced chewing impairment and difficulty in oral hygiene procedures, exhibited significantly lower scores of OHIP-14 at T14, and required a reduced number of anti-inflammatory medications in the first 7 days.Conclusions: Limosilactobacillus reuteri administration improved wound healing, reduced the severity of trismus, and was associated with improved PROs following impacted tooth extractions.Trial registration: The study protocol was registered in a clinical trials database (Clinicaltrials.gov) with registration number NCT04903925.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious Complications in Patients Receiving Superselective Intra-Arterial Chemoradiotherapy for Oral Squamous Cell Carcinoma. 口腔鳞状细胞癌超选择性动脉内放化疗患者的感染并发症。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-13 DOI: 10.1111/odi.70027

Hideaki Kato, Takashi Ohya, Toshiyuki Koizumi, Masaki Iida, Shoko Takano, Masaharu Hata, Hideaki Nakajima, Kenji Mitsudo

{"title":"Infectious Complications in Patients Receiving Superselective Intra-Arterial Chemoradiotherapy for Oral Squamous Cell Carcinoma.","authors":"Hideaki Kato, Takashi Ohya, Toshiyuki Koizumi, Masaki Iida, Shoko Takano, Masaharu Hata, Hideaki Nakajima, Kenji Mitsudo","doi":"10.1111/odi.70027","DOIUrl":"https://doi.org/10.1111/odi.70027","url":null,"abstract":"Objective: Superselective intra-arterial chemoradiotherapy (IACRT) is a radical treatment performed to preserve function in patients with oral cancer. However, the characteristics of infectious complications in this patient population and the prognostic impact remain unclear.Methods: We retrospectively reviewed 245 consecutive patients who underwent IACRT from 2008 to 2016. The characteristics of those who developed infectious complications during IACRT were compared with those who did not.Results: One hundred eighty-four infectious complications occurred during IACRT in 133/245 (54%) patients, including intra-arterial catheter site infection (19.0%, 2.7/1000 catheter-days), central line- and peripheral catheter-associated bloodstream infection (8.7%), febrile neutropenia (16.3%), pneumonia (8.7%), Clostridioides difficile infection (8.7%) and fever of unknown origin (26.6%). Multivariate regression analysis revealed that central venous catheter placement (adjusted odds ratio: 1.42) and Grade 3/4 neutropenia (adjusted odds ratio: 1.23) were significantly associated with infectious complications. Patients with infectious complications during IACRT had a worse prognosis than those without, with 5-year overall survival rates of 66.2% and 79.4%, respectively.Conclusions: Infectious complications during IACRT interrupt the course of cancer treatment, worsening prognosis. Thus, close monitoring and infection prevention measures are suggested to improve prognosis in patients with oral cancer undergoing IACRT.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0