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Effects of Antimicrobial Mouthwashes on Oral Health and Blood Pressure: A Preliminary Parallel Randomized Controlled Trial. 抗菌漱口水对口腔健康和血压的影响:一项初步平行随机对照试验。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-12 DOI: 10.1111/odi.70537
Debarati Bhowmick, Moumita Nayek, Azman Aquil, Argha Rudra, Surajit Mistry, Vineet Nair, Indrasri Das
{"title":"Effects of Antimicrobial Mouthwashes on Oral Health and Blood Pressure: A Preliminary Parallel Randomized Controlled Trial.","authors":"Debarati Bhowmick, Moumita Nayek, Azman Aquil, Argha Rudra, Surajit Mistry, Vineet Nair, Indrasri Das","doi":"10.1111/odi.70537","DOIUrl":"https://doi.org/10.1111/odi.70537","url":null,"abstract":"<p><strong>Objective: </strong>Although antimicrobial mouthwashes vary in efficacy and safety for managing biofilm-induced gingivitis, concerns remain regarding their potential to reduce nitric oxide bioavailability and increase hypertension risk. Therefore, we investigated whether octenidine is more effective and causes fewer adverse events than chlorhexidine, and whether antimicrobial mouthwash use increases hypertension risk.</p><p><strong>Methods: </strong>In this parallel randomized controlled trial, 90 participants were randomly allocated (1:1:1) to rinse with 10 mL of 2% saline (Group I), 0.2% chlorhexidine (Group II), or 0.1% octenidine (Group III) for 21 days. Co-primary outcomes (clinical parameters and blood pressure) and secondary outcomes (salivary bacterial count, adverse events, and pulse pressure) were assessed over 42 days.</p><p><strong>Results: </strong>At day 22, antimicrobial mouthwashes significantly reduced clinical (29%-52%) and microbial (> 92%) measures (p < 0.001), whereas saline produced minimal changes (p > 0.05). Salivary nitrate levels showed the opposite trend. Groups II and III showed comparable efficacy, but octenidine was associated with fewer adverse events. Although systolic blood pressure increased slightly in all groups, the changes were clinically insignificant. Elevated pulse pressure in antimicrobial groups returned to baseline by Day 42.</p><p><strong>Conclusions: </strong>Octenidine (0.1%) was safer and comparably effective to chlorhexidine. Short-term antimicrobial mouthwash had no clinically significant effect on blood pressure.</p><p><strong>Trial registration: </strong>CTRI/2024/08/072091 (India), date: 07/08/2024. URL: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTEwOTY5&Enc.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Factors Associated With Psychological Resilience in Sjögren's Disease. 探索Sjögren病心理弹性相关因素
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-09 DOI: 10.1111/odi.70530
Berceste Polat Akmansoy, Nur Sisman Kitapci, Ömür Mumcu, Fatma Büşra Sari, Şükrü Can Akmansoy, Esra Sevimli, Aysegül Avcu, Mustafa Erdogan, Umit Karacayli, Meral Yay, Farida Fortune, Nevsun Inanc, Gonca Mumcu
{"title":"Exploring Factors Associated With Psychological Resilience in Sjögren's Disease.","authors":"Berceste Polat Akmansoy, Nur Sisman Kitapci, Ömür Mumcu, Fatma Büşra Sari, Şükrü Can Akmansoy, Esra Sevimli, Aysegül Avcu, Mustafa Erdogan, Umit Karacayli, Meral Yay, Farida Fortune, Nevsun Inanc, Gonca Mumcu","doi":"10.1111/odi.70530","DOIUrl":"https://doi.org/10.1111/odi.70530","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to examine the factors associated with psychological resilience in Sjögren's disease.</p><p><strong>Methods: </strong>This cross-sectional study included 83 patients (F/M: 79/4). Hyposalivation was observed in 41%, while Schirmer's test positivity was observed in 84.3% of patients. Scores of the Brief Resilience Scale, self-reported general health, self-reported oral health, EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI), and physician global assessment for disease activity were noted. A mediation analysis was performed to examine the relationships among these variables.</p><p><strong>Results: </strong>Lower BRS scores were associated with Schirmer's test positivity and reduced salivary flow rate, higher scores of ESSPRI, physician and patient global assessments of disease activity (p < 0.05). In the simple mediation analysis, a lower BRS score as the dependent variable was directly associated with a higher physician-assessed global disease activity as the independent variable and indirectly associated with the higher ESSPRI score as a mediator variable (p < 0.05).</p><p><strong>Conclusions: </strong>Since ocular dryness, lower salivary flow rates, physician global assessment of disease activity, and ESSPRI reflecting patient-reported symptom severity were identified as key contributors to lower levels of psychological resilience in Sjögren's disease, these measures may offer clinicians valuable guidance for tailoring more effective, patient-centered integrated multidisciplinary care strategies for patients with SjD.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyaluronic Acid Microneedle With α-Boswellic Acid Heal Oral Ulcers by Anti-inflammatory Activity. α-乳香酸透明质酸微针抗炎治疗口腔溃疡。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-09 DOI: 10.1111/odi.70540
Wei Zhao, Zhuoqun Jia, Jiao Han, Xiaojun Sun
{"title":"Hyaluronic Acid Microneedle With α-Boswellic Acid Heal Oral Ulcers by Anti-inflammatory Activity.","authors":"Wei Zhao, Zhuoqun Jia, Jiao Han, Xiaojun Sun","doi":"10.1111/odi.70540","DOIUrl":"https://doi.org/10.1111/odi.70540","url":null,"abstract":"<p><strong>Objective: </strong>Conventional topical therapies for oral ulcers remain limited due to poor mucosal adhesion and rapid clearance by saliva. To overcome these challenges, we aimed to develop a microneedle patch with α-boswellic acid for targeted anti-inflammatory treatment of oral ulcers.</p><p><strong>Methods: </strong>The microneedle patch was fabricated and evaluated for mechanical strength and drug release profile. Biocompatibility was assessed. In vitro anti-inflammatory activity was examined in macrophages. In vivo efficacy was tested using a rat oral ulcer model.</p><p><strong>Results: </strong>The α-boswellic acid-loaded hyaluronic acid methacryloyl microneedle patch displayed adequate mechanical properties and sustained drug release. It exhibited favorable biocompatibility with low cytotoxicity and no apparent adverse effects on fibroblast migration. In vitro, the patch significantly inhibited pro-inflammatory cytokine and promoted M2 polarization. The patch accelerated ulcer healing, reducing the unhealed wound area in vivo. Enhanced collagen deposition and stimulated neovascularization were observed. Histological results demonstrated organized tissue regeneration, decreased neutrophil infiltration, and shifted macrophage phenotype.</p><p><strong>Conclusions: </strong>The α-boswellic acid-loaded hyaluronic acid methacryloyl microneedle patch effectively combines the anti-inflammatory activity of α-boswellic acid with the minimally invasive delivery advantages of the microneedle. This approach addresses key limitations of current topical treatments, demonstrating a promising therapeutic strategy for clinical translation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased Triglyceride-Glucose-Derived Metabolic and Inflammatory Indices in Periodontitis and Dyslipidemia. 牙周炎和血脂异常患者甘油三酯-葡萄糖衍生代谢和炎症指数升高。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-07 DOI: 10.1111/odi.70535
François Isnaldo Dias Caldeira, Alliny de Souza Bastos, Sâmia Cruz Tfaile Corbi, Raquel Mantuaneli Scarel-Caminaga, Silvana Regina Perez Orrico
{"title":"Increased Triglyceride-Glucose-Derived Metabolic and Inflammatory Indices in Periodontitis and Dyslipidemia.","authors":"François Isnaldo Dias Caldeira, Alliny de Souza Bastos, Sâmia Cruz Tfaile Corbi, Raquel Mantuaneli Scarel-Caminaga, Silvana Regina Perez Orrico","doi":"10.1111/odi.70535","DOIUrl":"https://doi.org/10.1111/odi.70535","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tooth Wear, Temporomandibular Disorders, Cervical Proprioception and Posture in Men Receiving Opioid Maintenance Treatment With Polysubstance Use History: A Case-Control Study. 接受阿片类药物维持治疗且有多物质使用史的男性的牙齿磨损、颞下颌疾病、颈椎本体感觉和姿势:一项病例对照研究
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-07 DOI: 10.1111/odi.70533
Besime Ahu Kaynak, İdil Esin Ünlü, Ece Ekici, Ümit Yüzbaşıoğlu, Oğuzhan Doğan
{"title":"Tooth Wear, Temporomandibular Disorders, Cervical Proprioception and Posture in Men Receiving Opioid Maintenance Treatment With Polysubstance Use History: A Case-Control Study.","authors":"Besime Ahu Kaynak, İdil Esin Ünlü, Ece Ekici, Ümit Yüzbaşıoğlu, Oğuzhan Doğan","doi":"10.1111/odi.70533","DOIUrl":"https://doi.org/10.1111/odi.70533","url":null,"abstract":"<p><strong>Objective: </strong>Substance use disorder (SUD) may contribute to tooth wear and temporomandibular disorders (TMDs), particularly in individuals undergoing opioid maintenance treatment (OMT). The primary aim of this study was to compare TMD-related clinical characteristics, including pain sensitivity, TMD presence, and tooth wear, between men in OMT and healthy controls.</p><p><strong>Materials and methods: </strong>This study included 37 males in OMT with a polysubstance use history and 37 controls. All participants underwent evaluation of pressure-pain thresholds (PPT), pain tolerance, and neck position sense. Presence of TMDs and tooth wear was evaluated by a maxillofacial surgeon. Severity of TMDs, posture, depression, and sleep quality were quantified using the Fonseca Anamnestic Index (FAI), New York Posture Rating Scale (NYPR), the Beck Depression Inventory (BDI), and the Pittsburgh Sleep Quality Index (PSQI), respectively.</p><p><strong>Results: </strong>Cervical proprioception differed significantly between groups (p < 0.001). Upper trapezius PPT and pain tolerance were lower in the OMT Group (p < 0.05). Tooth wear, TMD severity, sleep disturbance, and depression scores were higher, whereas posture scores were lower in the OMT group (p < 0.001).</p><p><strong>Conclusion: </strong>These findings support a comprehensive multidisciplinary assessment of oral, musculoskeletal, and psychosocial factors in individuals in OMT with a polysubstance use history.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary Microbiome Profiles in Burning Mouth Syndrome With Gastroesophageal Reflux Disease Comorbidity: A Comparative Analysis. 灼口综合征并发胃食管反流病的唾液微生物组对比分析
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-06 DOI: 10.1111/odi.70526
Linman Li, Shuangshuang Wu, Yajuan Cui, Luling Wang, Xinming Zhang, Zhimin Yan
{"title":"Salivary Microbiome Profiles in Burning Mouth Syndrome With Gastroesophageal Reflux Disease Comorbidity: A Comparative Analysis.","authors":"Linman Li, Shuangshuang Wu, Yajuan Cui, Luling Wang, Xinming Zhang, Zhimin Yan","doi":"10.1111/odi.70526","DOIUrl":"https://doi.org/10.1111/odi.70526","url":null,"abstract":"<p><strong>Objectives: </strong>Gastroesophageal reflux disease (GERD) has been recognized as a common comorbidity of burning mouth syndrome (BMS), suggesting potential interactions within the oral-gastrointestinal axis. This study aimed to test whether GERD comorbidity is associated with salivary microbiome profiles among patients with BMS.</p><p><strong>Materials and methods: </strong>Saliva samples from primary BMS patients without GERD (PBMS), BMS patients with GERD (GBMS), and healthy controls were analyzed using 16S rRNA gene sequencing. Microbial diversity, community structure, and differential taxa were assessed, and taxa were evaluated using receiver operating characteristic analysis.</p><p><strong>Results: </strong>Significant differences in salivary microbiome profiles were observed among GBMS, PBMS, and controls (p = 0.009). Both GBMS and PBMS showed higher abundances of Actinobacteriota and Rothia compared with controls, indicating shared BMS-associated microbial features. However, GBMS exhibited reduced microbial richness and enrichment of Porphyromonas and Parvimonas.</p><p><strong>Conclusions: </strong>BMS patients exhibit shared oral microbiome alterations, while GERD comorbidity is associated with a distinct salivary microbial profile characterized by reduced microbial richness and enrichment of Porphyromonas and Parvimonas. These findings suggest that GERD status may represent a potential clinical stratification factor for identifying biologically distinct subgroups of BMS, providing insight into disease heterogeneity and supporting future investigations of symptom variability and treatment response.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Variability in Oral Squamous Cell Carcinoma: A Retrospective Analysis Proposing a Practical Morphological Classification. 口腔鳞状细胞癌的临床变异性:提出实用形态学分类的回顾性分析。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-05 DOI: 10.1111/odi.70532
Nathalia Felix de Mendonca, Paulo Rogerio Ferreti Bonan, Hercílio Martelli Junior, Danyel Elias da Cruz Perez, Alessandro Villa, Luiz Paulo Kowalski, Márcio Ajudarte Lopes, Fabio Ramoa Pires, Fabio Abreu Alves
{"title":"Clinical Variability in Oral Squamous Cell Carcinoma: A Retrospective Analysis Proposing a Practical Morphological Classification.","authors":"Nathalia Felix de Mendonca, Paulo Rogerio Ferreti Bonan, Hercílio Martelli Junior, Danyel Elias da Cruz Perez, Alessandro Villa, Luiz Paulo Kowalski, Márcio Ajudarte Lopes, Fabio Ramoa Pires, Fabio Abreu Alves","doi":"10.1111/odi.70532","DOIUrl":"https://doi.org/10.1111/odi.70532","url":null,"abstract":"<p><strong>Objective: </strong>To propose a clinical classification system for oral squamous cell carcinoma (OSCC) based on lesion characteristics, aiming to enhance early recognition and initial clinical diagnostic hypothesis rate in clinical practice.</p><p><strong>Methods: </strong>A retrospective analysis of 422 OSCC cases was conducted from 2005 to 2023. Lesions were clinically categorized through clinical photographs as either \"conventional\" (including non-ulcerated plaques; red, white, or mixed and ulcerated infiltrative lesions with raised indurated margins) or \"atypical\" (different from the one described above) based on their presentation. Atypical cases were further subclassified into morphological types.</p><p><strong>Results: </strong>Of the 422 OSCC cases, 316 (74.9%) were classified as conventional and 106 (25.1%) as atypical. Conventional cases were predominantly ulcerative or leukoplakic, while atypical cases exhibited fissure-like and exophytic patterns. Tongue border was most commonly affected in conventional OSCC, while floor of the mouth and buccal mucosa predominated in atypical forms.</p><p><strong>Conclusion: </strong>Approximately one-quarter of OSCC cases present with atypical clinical features. The proposed classification provides a practical tool for clinicians to recognize these variants. However, further prospective validation is warranted to determine whether its application improves clinical recognition and diagnostic accuracy.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil-A Literature Review. 口腔溃疡和植物治疗:蜡菊精油的潜在作用——文献综述。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-05 DOI: 10.1111/odi.70531
Ruzica Ivkovic, Reka Antic, Avisek Majumder, Suravi Majumder, Dragana Stanisic
{"title":"Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil-A Literature Review.","authors":"Ruzica Ivkovic, Reka Antic, Avisek Majumder, Suravi Majumder, Dragana Stanisic","doi":"10.1111/odi.70531","DOIUrl":"https://doi.org/10.1111/odi.70531","url":null,"abstract":"<p><strong>Background: </strong>Recurrent aphthous stomatitis (RAS) is a common yet therapeutically challenging chronic inflammatory disease of the oral mucosa, characterized by recurrent, painful ulcerations that substantially affect patients' quality of life.</p><p><strong>Objective: </strong>This review summarizes current evidence on phytotherapy in RAS, with particular focus on the potential therapeutic relevance of Helichrysum italicum essential oil (HI EO).</p><p><strong>Findings and discussion: </strong>Phytotherapy has been investigated as a therapeutic option for RAS, primarily due to its reported ability to reduce pain, shorten healing time, and promote ulcer resolution. Additionally, some phytotherapeutic preparations may offer a favorable tolerability profile, although their safety and comparative efficacy require further evaluation. Phytotherapy may therefore be considered as an adjunctive or complementary approach in the management of RAS. Previous research on HI EO provides a biological rationale for investigating its potential relevance to oral mucosal healing. However, its potential role in RAS remains hypothetical because direct clinical evidence regarding its efficacy and safety is currently lacking. This hypothesis therefore requires further investigation in clinical studies.</p><p><strong>Conclusion: </strong>Phytotherapy represents a potential supplementary approach to RAS management. The therapeutic potential of HI EO requires validation through rigorously designed preclinical and clinical studies evaluating its efficacy, safety, and clinical relevance.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic Inflammatory Ratios Predict Survival in Oral Squamous Cell Carcinoma. 全身炎症比例预测口腔鳞状细胞癌患者的生存。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-05 DOI: 10.1111/odi.70515
Idan Gavrielov, Alex Dobriyan, Idan Shavit, Marilena Vered
{"title":"Systemic Inflammatory Ratios Predict Survival in Oral Squamous Cell Carcinoma.","authors":"Idan Gavrielov, Alex Dobriyan, Idan Shavit, Marilena Vered","doi":"10.1111/odi.70515","DOIUrl":"https://doi.org/10.1111/odi.70515","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the prognostic value of the systemic inflammation-related biomarkers of neutrophil-lymphocyte, albumin-globulin, lymphocyte-monocyte, and platelet-lymphocyte ratios at three perioperative time points, and to explore their association with clinicopathologic features and disease-specific survival.</p><p><strong>Methods: </strong>In 220 oral squamous cell carcinoma patients undergoing surgery (2012-2023), we assessed risk factors, such as extranodal extension, TNM stage, and biomarker cutoffs (neutrophil-lymphocyte 5.0; albumin-globulin 1.21; lymphocyte-monocyte 3.14; platelet-lymphocyte 218.9). Disease-specific survival was analyzed using Kaplan-Meier curves, log-rank tests, and Cox multivariate models. Significance set at p < 0.05.</p><p><strong>Results: </strong>Biomarkers measured 3 months postoperatively were the strongest predictors. Multivariate analysis identified high neutrophil-lymphocyte (HR = 2.99, 95% CI 1.44-6.21; p = 0.003), low albumin-globulin (HR = 0.44, 95% CI 0.21-0.89; p = 0.023) ratios, and extranodal extension (HR = 3.17, 95% CI 1.54-6.52; p = 0.002) as independent predictors of poorer disease-specific survival. Importantly, neutrophil-lymphocyte prognostic impact was comparable to that of extranodal extension, a well-established pathological risk factor.</p><p><strong>Conclusions: </strong>Three months post-surgery, high neutrophil-lymphocyte and low albumin-globulin ratios independently predict worse disease-specific survival in oral cancer. Neutrophil-lymphocyte, a simple and widely available biomarker, offers prognostic insight comparable to extranodal extension, supporting its integration into postoperative risk stratification and potentially guiding adjuvant therapy decisions.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Level of BP180 and BP230 Autoantibody Reactivity in Oral Lichen Planus Does Not Predict Early Lichen Planus Pemphigoides. 低水平BP180和BP230自身抗体反应性口腔扁平苔藓不能预测早期天疱疮扁平苔藓。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-10-05 DOI: 10.1111/odi.70538
Gabusi Andrea, Bardazzi Federico, Filippi Federica, Misciali Cosimo, La Placa Michelangelo, Clarizio Giacomo, Rossi Roberto, Gissi Davide
{"title":"Low-Level of BP180 and BP230 Autoantibody Reactivity in Oral Lichen Planus Does Not Predict Early Lichen Planus Pemphigoides.","authors":"Gabusi Andrea, Bardazzi Federico, Filippi Federica, Misciali Cosimo, La Placa Michelangelo, Clarizio Giacomo, Rossi Roberto, Gissi Davide","doi":"10.1111/odi.70538","DOIUrl":"https://doi.org/10.1111/odi.70538","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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