Oral diseasesPub Date : 2025-09-18DOI: 10.1111/odi.70099
Kristina Skallsjö, Michael T Brennan, Bengt Hasséus, Jenny Öhman, Judith E Raber-Durlacher, Marie-Charlotte D N J M Huysmans, Alexa M G A Laheij, Stephanie J M van Leeuwen, Allan J Hovan, Karin Garming Legert, Scott Isom, David M Kline, Nicole M A Blijlevens, Jan-Erik Johansson, Inger von Bültzingslöwen
{"title":"Patient-Reported Oral Symptoms and Their Impact on Well-Being After Haematopoietic Cell Transplantation.","authors":"Kristina Skallsjö, Michael T Brennan, Bengt Hasséus, Jenny Öhman, Judith E Raber-Durlacher, Marie-Charlotte D N J M Huysmans, Alexa M G A Laheij, Stephanie J M van Leeuwen, Allan J Hovan, Karin Garming Legert, Scott Isom, David M Kline, Nicole M A Blijlevens, Jan-Erik Johansson, Inger von Bültzingslöwen","doi":"10.1111/odi.70099","DOIUrl":"https://doi.org/10.1111/odi.70099","url":null,"abstract":"<p><strong>Objective: </strong>Oral complications may negatively influence outcomes of haematopoietic cell transplantation (HCT). A comprehensive view of oral symptoms and symptom burden post-HCT is lacking. This study aimed to determine the prevalence, severity, and temporal relationships of oral symptoms and their impact on well-being in the early post-HCT phase. Effects of transplant type and conditioning intensity were evaluated.</p><p><strong>Methods: </strong>In this prospective multicentre observational study, adult HCT recipients were interviewed and completed questionnaires on oral symptoms and well-being three times a week during hospitalisation early post-HCT.</p><p><strong>Results: </strong>Of 194 patients, 177 (91.2%) reported oral symptoms. Dry mouth was the earliest and most common (80.9%) followed by oral pain (35.6%), thickening/swollen mucosa (33.0%), and taste changes (30.9%). Symptom frequency peaked on days 6 to 11 post-HCT and caused significant burden: 59.3% experienced moderate to severe distress and 53.6% reported moderate to severe impact on well-being. Symptom prevalence was highest among patients who received allogeneic HCT with MAC and those who underwent autologous HCT. Overall, MAC regimens were associated with earlier and more frequent symptoms, greater distress and higher impact on well-being during days 0 to 11 post-HCT compared to reduced/non-myeloablative regimens.</p><p><strong>Conclusions: </strong>Oral symptoms are prevalent, burdensome and significantly impact well-being early post-HCT, underscoring the need for close monitoring and supportive oral care.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-18DOI: 10.1111/odi.70098
Briana Jansen, Stella Mullane, Bryan Tan, Bobby Joseph, Mohammed Junaid, Ramesh Balasubramaniam, Agnieszka Frydrych, Omar Kujan
{"title":"Patient-Centred Web-Based Information on Head and Neck Squamous Cell Carcinoma: Quality and Readability.","authors":"Briana Jansen, Stella Mullane, Bryan Tan, Bobby Joseph, Mohammed Junaid, Ramesh Balasubramaniam, Agnieszka Frydrych, Omar Kujan","doi":"10.1111/odi.70098","DOIUrl":"https://doi.org/10.1111/odi.70098","url":null,"abstract":"<p><strong>Introduction: </strong>The internet is a widely used source of health information for patients with head and neck cancer. However, the quality and readability of online content remain inconsistent. This study evaluated the usefulness of web-based resources by assessing their quality and readability.</p><p><strong>Methods: </strong>Searches were conducted using Google, Bing, and Yahoo! with nine common anatomical terms related to head and neck cancer. The first 50 results from each search engine were screened, and eligible websites were evaluated for quality using the DISCERN instrument by three independent reviewers. Readability was assessed using the Flesch-Kincaid Reading Grade Level (FKRGL) and the Flesch Reading Ease Score (FRES). Descriptive and inferential statistics were applied.</p><p><strong>Results: </strong>A total of 285 websites met the inclusion criteria. Of these, 46% were rated as poor quality (DISCERN score = 1). The median FKRGL was 8.6, and the median FRES was 55.7, both indicating reading levels above recommended thresholds for patient education materials.</p><p><strong>Conclusions: </strong>Online information for patients with head and neck squamous cell carcinoma is often of low quality and too complex for the average reader. Improved, accessible, and reliable web-based resources are needed to support patient understanding and informed healthcare decisions.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70097
Efsun Somay
{"title":"Re \"Effects of Bisphosphonates and Denosumab on Dental Implants: A Systematic Review With Meta-Analysis\".","authors":"Efsun Somay","doi":"10.1111/odi.70097","DOIUrl":"https://doi.org/10.1111/odi.70097","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70086
Anna Maria Camarda, Giulia Fontana, Barbara Vischioni, Amelia Barcellini, Maria Bonora, Jessica Franzetti, Nadia Facchinetti, Federica Serra, Carmine Tinelli, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Pierluigi Bonomo, Sara Colombo, Daniela Alterio, Nicola Alessandro Iacovelli, Marzia Franceschini, Giovanni Ivaldi, Marco Trovò, Elisa D'Angelo, Ester Orlandi
{"title":"COMBINATORIC: Carbon Ion Boost With Photons or Protons in Salivary Gland and Sinonasal Cancers.","authors":"Anna Maria Camarda, Giulia Fontana, Barbara Vischioni, Amelia Barcellini, Maria Bonora, Jessica Franzetti, Nadia Facchinetti, Federica Serra, Carmine Tinelli, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Pierluigi Bonomo, Sara Colombo, Daniela Alterio, Nicola Alessandro Iacovelli, Marzia Franceschini, Giovanni Ivaldi, Marco Trovò, Elisa D'Angelo, Ester Orlandi","doi":"10.1111/odi.70086","DOIUrl":"https://doi.org/10.1111/odi.70086","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the outcomes of combining carbon ion radiotherapy boost (CIRTb) with photons (Ph) or protons (PT) for locally advanced salivary gland and sinonasal cancers (SGCs and SNCs).</p><p><strong>Materials and methods: </strong>Sixty-nine patients with SGCs and SNCs received CIRTb to high-risk CTV and Ph or PT to low-risk CTV (LR-CTV) from October 2014 to September 2022. Two-year local relapse-free survival (LRFS) was analyzed with Kaplan-Meier. Toxicity according to Common Terminology Criteria for Adverse Events v5. Variables affecting toxicities were analyzed with chi-squared and Mann-Whitney U tests.</p><p><strong>Results: </strong>Patients received a median CIRTb dose of 15 Gy RBE, with 29 (41%) receiving Ph and 42 (59%) receiving PT. With a median follow-up of 17.23 months, 2-year LRFS achieved 87.8% (95% CI: 79.6-96.8). Female (p = 0.045) reported better 2-year LRFS rates: 95.2% (95% CI: 86.6-100) versus 81.8% (95% CI: 69.5-96.2). Acute and late G2+ toxicity were, respectively, 80% and 60%. Ph (p = 0.004) and smaller LR-CTV (p = 0.004) reduced acute and late toxicities. No G4 late toxicity was reported.</p><p><strong>Conclusions: </strong>CIRT combined with Ph or PT seems a valuable option for locally advanced SGCs and SNCs. Prospective studies are needed to select the best treatment combination.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-09DOI: 10.1111/odi.70091
Cristina Saldivia-Siracusa, Alessandro Villa, Alan Roger Santos-Silva
{"title":"Crying and Emotional Distress Among Patients in Oral Medicine: A Common and Challenging Scenario.","authors":"Cristina Saldivia-Siracusa, Alessandro Villa, Alan Roger Santos-Silva","doi":"10.1111/odi.70091","DOIUrl":"https://doi.org/10.1111/odi.70091","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cinnamon-Induced Contact Stomatitis: A Retrospective Study of 74 Cases and Literature Review.","authors":"Eleni-Marina Kalogirou, Aikaterini Aktypi-Bampouranou, Marianna Vasilaki, Konstantina Chatzidimitriou, Konstantinos I Tosios","doi":"10.1111/odi.70081","DOIUrl":"https://doi.org/10.1111/odi.70081","url":null,"abstract":"<p><strong>Objective: </strong>Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.</p><p><strong>Materials and methods: </strong>This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used. The literature was reviewed for similar CCS cases, documented by relevant history and at least one clinical/histopathological image.</p><p><strong>Results: </strong>Seventy-four patients were diagnosed with CCS that mainly involved the buccal mucosa (67/74) and/or lateral tongue (50/74). White lichenoid or plaque-type lesions were observed in seven patients, erythematous/erosive/ulcerative lesions in 26 patients, and combined whitish-red lesions in 41 patients. Discontinuation of CCPs resulted in complete resolution within a week in all cases. The literature review yielded 40 well-documented cases of CCS related to chewing gums, candies, or mints.</p><p><strong>Conclusion: </strong>The presence of erythematous and/or white lesions at the occlusal plane should raise suspicion of CCS that can be diagnosed based on the patient's history and clinical presentation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseasesPub Date : 2025-09-07DOI: 10.1111/odi.70092
Renato Assis Machado, Sara Garcia Azevedo, Lilianny Querino Rocha de Oliveira, Hercílio Martelli Júnior, Ricardo D Coletta
{"title":"Authors' Reply \"Tooth Anomalies in Patients With Nonsyndromic Orofacial Cleft: A Systematic Review and Meta-Analysis\".","authors":"Renato Assis Machado, Sara Garcia Azevedo, Lilianny Querino Rocha de Oliveira, Hercílio Martelli Júnior, Ricardo D Coletta","doi":"10.1111/odi.70092","DOIUrl":"https://doi.org/10.1111/odi.70092","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}