Oral diseases最新文献_第2页

Advancing Research on Obesity and Salivary Microbiota: A Community Health Perspective. 推进肥胖与唾液微生物群的研究：社区健康视角。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15199

Yu Feng, Chang Liu, Yifan Hao, Hui Gu

引用次数: 0

ApoEVs Transfer Mitochondrial Component to Modulate Macrophages in Periodontal Regeneration. 载脂蛋白EV转移线粒体成分，调节牙周再生中的巨噬细胞。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15181

Xiaodong Liu, Yun Lyu, Yejia Yu, Zhuo Wang, Yanping Sun, Maojiao Li, Chao Liang, Weidong Tian, Li Liao

{"title":"ApoEVs Transfer Mitochondrial Component to Modulate Macrophages in Periodontal Regeneration.","authors":"Xiaodong Liu, Yun Lyu, Yejia Yu, Zhuo Wang, Yanping Sun, Maojiao Li, Chao Liang, Weidong Tian, Li Liao","doi":"10.1111/odi.15181","DOIUrl":"https://doi.org/10.1111/odi.15181","url":null,"abstract":"Objective: Macrophages are key players in the host immune response to periodontal pathogens and tissue repair. The aim of this study was to explore the potential of apoptotic cell-derived extracellular vesicles (ApoEVs) in modulating the mitochondrial function of macrophages as a mean to enhance periodontal tissue regeneration.Subjects and methods: ApoEVs were extracted from periodontal ligament stem cells (PDLSCs) and characterized to observe their effects on macrophage function. In vivo experiments, ApoEVs were mixed with hyaluronic acid and injected into the periodontal pockets of rats with periodontitis to observe their impact on periodontal tissue regeneration and the immune microenvironment. Functional assays were conducted to confirm whether ApoEVs contained mitochondrial components and which specific components were transferred to regulate macrophage function.Results: The experimental findings showed that treatment of ApoEVs efficiently restored the homeostasis of macrophage and improved tissue regeneration in a periodontitis rat model. Mechanism investigation demonstrated that the efferocytosis of ApoEVs resulted in the transfer of mitochondrial components from PDLSCs to macrophage. The increased mitochondrial components within macrophages improved mitochondrial function and polarization of macrophages towards the anti-inflammatory M2 phenotype, resulting in the improvement of inflammatory environment in periodontal tissues.Conclusion: ApoEVs can transfer mtDNA to enhance mitochondrial function in macrophages, fostering their transition to an anti-inflammatory phenotype. Ultimately, this process improves the immune microenvironment in periodontitis and promotes periodontal tissue regeneration.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells. OLP 病变中的 HSP90 复合物通过激活树突状细胞诱导 T 细胞极化

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15195

Lei Pan, Junjun Chen, Yirao Lai, Guanhuan Du, Haiyan Wang, Lei Sun, Guoyao Tang, Yufeng Wang

{"title":"HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells.","authors":"Lei Pan, Junjun Chen, Yirao Lai, Guanhuan Du, Haiyan Wang, Lei Sun, Guoyao Tang, Yufeng Wang","doi":"10.1111/odi.15195","DOIUrl":"https://doi.org/10.1111/odi.15195","url":null,"abstract":"Objectives: To investigate the effects of the heat shock protein 90 (HSP90) complex from oral lichen planus (OLP) lesion tissues on dendritic cell (DC) activation and the polarization of naïve T cells.Methods: Expression of HSP90 in OLP lesions and healthy control (HC) mucosa was evaluated by single-cell RNA sequence, IHC, qRT-PCR, and immunoblotting. HSP90 complex was extracted by immunoprecipitation from oral mucosa as the agonist of DCs. Expression of IFN-α and MHC was detected by flow cytometry. After cocultured with pre-stimulated DCs, polarization of naïve T cells was investigated by cytokine analysis.Results: HSP90 was significantly higher in the lamina propria of OLP lesion and closely related to lymphocyte infiltration. HSP90 complex of OLP lesion activated DCs via TLR9 and increased their IFN-α secretion and MHC II expression. Pre-stimulated DCs increased the proportion of Th17 cells.Conclusions: HSP90 complex isolated from OLP lesion activated TLR9/IFN-α of DCs and further promoted the polarization of naïve T cells toward Th17 immunity.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil Extracellular Traps in Oral Diseases. 口腔疾病中的中性粒细胞胞外捕获器

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15197

Pengfei Gao, Jun Zhou, Lu Sun, Dayong Liu

{"title":"Neutrophil Extracellular Traps in Oral Diseases.","authors":"Pengfei Gao, Jun Zhou, Lu Sun, Dayong Liu","doi":"10.1111/odi.15197","DOIUrl":"https://doi.org/10.1111/odi.15197","url":null,"abstract":"Objective: To summarize the current knowledge of the neutrophil extracellular traps (NETs) and its critical role in various oral diseases.Methods: We reviewed the recent research on NETs through PubMed and Web of Science. An analysis of recent research results was summarized from three aspects: NETs induction and formation, functions of NETs, and NETs in oral diseases.Results: The relationship between neutrophils and NETs is critical to the body's defense against microbial invasion. NETs can effectively combat pathogens with an anti-inflammatory effect and meanwhile it can contribute to inflammation. Moreover, it can synergize with other immune cells to respond to stimuli, such as pathogens, host-derived mediators, and drugs. It was revealed that NETs play different roles to influence various oral diseases like periodontitis, endodontic infection, oral mucosal diseases, maxillofacial tumors, and many other oral diseases.Conclusion: The balance between the protective and potentially harmful effects of NETs is a key factor in determining the outcome of infections and inflammatory responses. The role of NETs in oral diseases needs to be further studied to enable better understanding of its role in the different oral diseases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Aphthous Stomatitis and Sleep Quality Factors: A Comprehensive Analysis. 复发性口腔炎与睡眠质量因素：综合分析

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-07 DOI: 10.1111/odi.15189

Sina Bazmi, Zahra Mohammadi, Reza Tabrizi, Maryam Kazemi

{"title":"Recurrent Aphthous Stomatitis and Sleep Quality Factors: A Comprehensive Analysis.","authors":"Sina Bazmi, Zahra Mohammadi, Reza Tabrizi, Maryam Kazemi","doi":"10.1111/odi.15189","DOIUrl":"https://doi.org/10.1111/odi.15189","url":null,"abstract":"Background: Due to the unclear etiology of recurrent aphthous stomatitis (RAS), a painful and distressing condition with a high prevalence, the researchers have hypothesized a connection between sleep quality and RAS.Methods: The cross-sectional study enrolled 10,138 Fasa Cohort Study participants aged 35-70 years. Various sleep quality factors were calculated and categorized based on the Pittsburgh Sleep Questionnaire.Results: Among 9030 subjects finally included with RAS prevalence of 20.2%, adjusted logistic regression showed significant odds ratios (ORs) in subjects who sleep < 5 h (OR = 1.44, 95%CI 1.25, 1.66), have sleep latencies of more than 60 min (OR = 1.37, 95%CI 1.11, 1.69), have sleep efficiencies of 65%-75% (OR = 1.55, 95%CI 1.21, 1.98), or regularly go to bed after 11 p.m. (OR = 1.23, 95%CI 1.11, 1.37). Subgroup analyses indicated no significant associations between RAS and various sleep factors in individuals who worked night shifts, and stronger associations were observed in men than women.Conclusion: The study found a significant positive association between RAS and sleep quality factors such as shorter duration, lower efficiency, longer latency, later bedtime, and regular sleeping pill use. Establishing early and sufficient sleep and addressing sleep onset disturbances by adhering to sleep hygiene principles should be prioritized in individuals with RAS.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Binary Grading Better Than WHO System for Grading Epithelial Dysplasia? A Systematic Review and Meta-Analysis. 二元分级比 WHO 上皮增生异常分级系统更好吗？系统回顾与元分析》。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-06 DOI: 10.1111/odi.15160

Divya Gopinath, Cheng Yung On, Sajesh Kalkandi Veettil, W M Tilakaratne

{"title":"Is Binary Grading Better Than WHO System for Grading Epithelial Dysplasia? A Systematic Review and Meta-Analysis.","authors":"Divya Gopinath, Cheng Yung On, Sajesh Kalkandi Veettil, W M Tilakaratne","doi":"10.1111/odi.15160","DOIUrl":"10.1111/odi.15160","url":null,"abstract":"Background: This meta-analysis summarizes the current evidence on the intra- and inter-observer agreement between WHO and the binary grading systems used to assess epithelial dysplasia (ED).Methods: A systematic search for observational studies that compared the level of agreement among pathologists between WHO and binary grading systems for ED was conducted using three databases: Medline, Scopus, and EBSCOhost. For the meta-analysis, summary estimations of kappa value (κ) and standard error (SE) were utilized.Results: The pooled analysis of observations by 46 pathologists from a total of eight studies showed better interobserver agreement in the interpretation of ED for the binary system (κ = 0.31; 95% confidence interval [CI], 0.23-0.40) in comparison with the WHO (κ = 0.14; 95% CI, 0.10-0.19). The intra-observer agreement was reported only by five studies and was also found to be higher for the binary system (κ = 0.44; 95% CI, 0.31-0.57) compared to the WHO (κ = 0.25; 95% CI, 0.11-0.39).Conclusions: Our results validate that the binary system has better overall intra-observer and interobserver agreement than the WHO system. Further studies with larger cohorts are mandatory before clinically relevant conclusions are drawn, as evidence remains inadequate.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter About the Article "Hydroxychloroquine Is Effective in Oral Lichen Planus". 关于 "羟氯喹对口腔扁平苔藓有效 "一文的来信

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-06 DOI: 10.1111/odi.15177

Wei-Zhen Tang, Xue-Bing Chen, Tai-Hang Liu

引用次数: 0

Hormone Replacement Therapy Relieves Periodontitis by Inhibiting Alveolar Bone Loss and Inflammation. 激素替代疗法通过抑制牙槽骨流失和炎症缓解牙周炎

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-06 DOI: 10.1111/odi.15192

Ying Man, Jianyong Qin, Hongliang Qiu, Yiying Wang, Xinyue Zhang, Shengjie Yan

{"title":"Hormone Replacement Therapy Relieves Periodontitis by Inhibiting Alveolar Bone Loss and Inflammation.","authors":"Ying Man, Jianyong Qin, Hongliang Qiu, Yiying Wang, Xinyue Zhang, Shengjie Yan","doi":"10.1111/odi.15192","DOIUrl":"10.1111/odi.15192","url":null,"abstract":"Objective: Hormone replacement therapy (HRT) is a commonly used strategy for treating menopausal symptoms, while its relation with periodontitis remains unclear. This study aimed to explore the potential effects of HRT on periodontitis, mainly in aspects of bone loss and inflammation.Methods: The alveolar bone height (ABH), alveolar bone thickness (ABT), and bone mineral density (BMD) were measured in menopausal women with periodontitis who had received HRT or had not received HRT by cone beam computed tomography. Based on a rat model of periodontitis, the alveolar bone loss was evaluated by micro-computed tomography and bone-related biochemical markers. The expression/levels of inflammatory markers were measured to reflect periodontal inflammation.Results: Although the differences were not all significant in each premolars/molars, the mesial/distal ABH and buccal/lingual ABT were lower, and the mesial/distal BMD was higher in patients in the HRT group than those in the control group. In a rat model of periodontitis, the alveolar bone loss was relieved by HRT. Additionally, HRT significantly weakened the elevation of inflammatory markers, including TNF-α, IL-1β, and IL-6 in periodontitis rats.Conclusions: HRT contributes to the remission of periodontitis by inhibiting alveolar bone loss and inflammation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second Events After Curative-Intent Treatment for Lip Cancer: Navigating the Path of Follow-Up Care. 唇癌治愈性治疗后的第二次事件：引领后续护理之路。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-06 DOI: 10.1111/odi.15194

Fábio Muradás Girardi, Amanda de Farias Gabriel, Vivian Petersen Wagner, Manoela Domingues Martins

{"title":"Second Events After Curative-Intent Treatment for Lip Cancer: Navigating the Path of Follow-Up Care.","authors":"Fábio Muradás Girardi, Amanda de Farias Gabriel, Vivian Petersen Wagner, Manoela Domingues Martins","doi":"10.1111/odi.15194","DOIUrl":"10.1111/odi.15194","url":null,"abstract":"Objective: We aimed to investigate the pattern, risk, and treatment of subsequent events after curative-intent treatment of lip cancer.Methods: This retrospective cohort study included 313 patients treated for lip cancer from 2011 to 2021 in a tertiary oncological center.Results: After a median follow-up time of 29.16 months, 145 (46.32%) patients presented with second primary tumors, 93% of which were skin carcinomas. Locoregional recurrence occurred in 7.9% of cases, with 2.5% with nodal recurrence. The 1-, 5-, and 10-year cumulative second primary tumor probabilities were 32.8%, 60.92%, and 70.92%, respectively. A higher risk was observed in elderly patients and basal cell carcinoma cases located on the cutaneous surface of the upper lip. Regional metastasis but not second primary tumors negatively impacted survival.Conclusions: Our study helps fill a literature gap, structuring specific recommendations regarding evaluations and follow-up protocols for patients with lip cancer. Since cutaneous second primary tumors were the most common second event, standard skin examination is key. Age and histology were significant predictors for second primary tumors. For cases of locally advanced lip squamous cell carcinoma, standard guidelines for head and neck cancer must be followed.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone Lysine Lactylation (Kla)-induced BCAM Promotes OSCC Progression and Cis-Platinum Resistance. 组蛋白赖氨酸乳化（Kla）诱导的 BCAM 促进 OSCC 进展和顺铂抗性

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-06 DOI: 10.1111/odi.15179

Guangzhao Huang, Su Chen, Jialu He, Honglin Li, Zhongkai Ma, Grace Paka Lubamba, Lei Wang, Zhiyong Guo, Chunjie Li

{"title":"Histone Lysine Lactylation (Kla)-induced BCAM Promotes OSCC Progression and Cis-Platinum Resistance.","authors":"Guangzhao Huang, Su Chen, Jialu He, Honglin Li, Zhongkai Ma, Grace Paka Lubamba, Lei Wang, Zhiyong Guo, Chunjie Li","doi":"10.1111/odi.15179","DOIUrl":"https://doi.org/10.1111/odi.15179","url":null,"abstract":"Objective: Histone lysine lactylation (Kla) plays a vital role in cancer progression. However, the prognostic value of histone Kla in oral squamous cell carcinoma (OSCC) remains unclear.Materials and methods: OSCC RNA expression data were obtained from the TCGA and GEO databases. We explored the prognostic value of histone Kla in OSCC via constructing a Cox model and determined the role of Kla in OSCC drug susceptibility and tumor microenvironment (TME). In addition, the biological roles of candidate biomarkers were identified.Results: A total of 1223 Kla-specific genes were obtained, with 228 DEKlaGs in OSCC. GO and KEGG enrichment analyses suggested that DEKlaGs contributed to inflammatory and cancer progression. A Cox model in accordance with BCAM, CGNL1, DGKG, and OLR1 could predict OSCC patient prognosis accurately. Subsequently, Kla-induced prognostic genes were identified to play a crucial role in OSCC drug therapy and TME. Moreover, BCAM was identified as a biomarker that promoted OSCC invasion, angiogenesis, and chemotherapy resistance.Conclusion: Kla was identified to be associated with OSCC prognosis, drug therapy, and TME. Histone Kla-induced BCAM was identified to play a crucial role during OSCC progression, suggesting that Kla is promising to be a novel therapeutic target for OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0