Oral diseases最新文献_第2页

Identification of PANoptosis-Related Biomarkers in Head and Neck Squamous Cell Carcinoma. 头颈部鳞状细胞癌panoposis相关生物标志物的鉴定。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-24 DOI: 10.1111/odi.70307

Yichao Xia, Huiquan Lou, Shengjie Shao, Xiang Liu, Yongsheng Li

{"title":"Identification of PANoptosis-Related Biomarkers in Head and Neck Squamous Cell Carcinoma.","authors":"Yichao Xia, Huiquan Lou, Shengjie Shao, Xiang Liu, Yongsheng Li","doi":"10.1111/odi.70307","DOIUrl":"https://doi.org/10.1111/odi.70307","url":null,"abstract":"Background: The early detection and diagnosis of head and neck squamous cell carcinoma (HNSCC) pose significant challenges.Objectives: This study explores the diagnostic and prognostic role of PANoptosis-related genes (PANRGs) in HNSCC.Methods: In this study, machine learning was used to identify PANoptosis-related biomarkers in HNSCC, and a corresponding prognostic risk model was constructed.Results: This study identified ZBP1, RIPK1, FADD, and RNF31 as biomarkers for HNSCC, among which ZBP1, RIPK1, and RNF31 served as protective factors, while FADD functioned as a risk factor. Based on the median Risk Score of the biomarkers, the validation set was categorized into high-risk and low-risk groups. NOBOX, SOX14, GBX1, and NKX2-4 were identified as hub genes playing critical roles in distinguishing the high-risk and low-risk groups, and these hub genes were significantly negatively enriched in the PPAR signaling pathway. Furthermore, immune infiltration analysis revealed that the abundance of immune cells in the low-risk group was significantly higher than that in the high-risk group.Conclusion: This study identified four PANoptosis-related biomarkers in HNSCC, with ZBP1, RIPK1, and RNF31 as protective factors and FADD as a risk factor. These findings provide new references for improving the prognosis of HNSCC patients and developing novel therapeutic strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Oral and Eyelid Nodules in a Pediatric Patient. 儿科患者多发性口腔和眼睑结节。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-21 DOI: 10.1111/odi.70187

Caique Mariano Pedroso, Paulo Victor Mendes Penafort, Patrícia Vitor de Souza, Fernanda M Pascon, Regina Maria Punppin-Rontani, Beatriz Frolini Paulo Cherve, Rachel Marinho Robim, Regina Maria Holanda de Mendonça, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva

引用次数: 0

Comment on "Prevalence of Burning Mouth Syndrome in Parkinson's Disease: A Prospective Case-Control Study". 《帕金森病患者灼口综合征患病率：一项前瞻性病例-对照研究》评论

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-20 DOI: 10.1111/odi.70343

Yong-Chan Liu, Hong-Tian Chen, Qing-Qing Yang, Wei-Min Hong, Yang-Zhou Huang

引用次数: 0

Quality and Readability of Large Language Models' Responses to Oral Lichen Planus Patients' FAQs. 大型语言模型回答口腔扁平苔藓患者常见问题的质量和可读性。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-20 DOI: 10.1111/odi.70334

Alessandro Polizzi, Gaetano Isola, Vito Carlo Alberto Caponio, Alan Roger Santos-Silva, José González-Serrano, Rui Albuquerque, Vlaho Brailo, Arwa Mohammad Farag, María Pía López Jornet, Jairo Robledo Sierra, Thomas Peter Sollecito, Hongxia Dan, Márcio Diniz Freitas, Caroline Bissonnette, Paswach Wiriyakijja, Gonzalo Hernández, Rosa María López-Pintor

{"title":"Quality and Readability of Large Language Models' Responses to Oral Lichen Planus Patients' FAQs.","authors":"Alessandro Polizzi, Gaetano Isola, Vito Carlo Alberto Caponio, Alan Roger Santos-Silva, José González-Serrano, Rui Albuquerque, Vlaho Brailo, Arwa Mohammad Farag, María Pía López Jornet, Jairo Robledo Sierra, Thomas Peter Sollecito, Hongxia Dan, Márcio Diniz Freitas, Caroline Bissonnette, Paswach Wiriyakijja, Gonzalo Hernández, Rosa María López-Pintor","doi":"10.1111/odi.70334","DOIUrl":"https://doi.org/10.1111/odi.70334","url":null,"abstract":"Objective: To evaluate the quality and readability of large language models (LLMs) when responding to Frequently Asked Questions (FAQs) about oral lichen planus (OLP).Methods: We evaluated the responses of three LLMs (ChatGPT-4o, Gemini 2.0 Flash Experimental, and Copilot) to 13 patient-centered FAQs about OLP. Questions were identified using query tools, and answers were assessed by 14 oral medicine experts using the Quality Assessment of Medical Artificial Intelligence (QAMAI) tool. Readability was analyzed with the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKG) tools.Results: All LLMs provided generally accurate and relevant responses, with median QAMAI scores indicating \"good\" to \"very good\" quality. ChatGPT achieved slightly higher completeness, particularly for questions on OLP definition and treatment. The reference provision was inconsistent across all chatbots. Readability analysis revealed that most responses required college-level literacy, with ChatGPT producing the most complex texts, Gemini occasionally achieving more accessible outputs, and Copilot situated in an intermediate position.Conclusions: LLMs may have potential as adjunctive tools for patient education in OLP, although they remain limited by incomplete information, inconsistent references, and suboptimal readability. Future research should incorporate longitudinal LLMs evaluations and training to develop models delivering accurate, accessible information, tailored to users' literacy levels.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser Acupuncture on the Management of Xerostomia in Sjögren's Disease: A Randomized Clinical Trial. 激光针刺治疗Sjögren病口干：一项随机临床试验

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-20 DOI: 10.1111/odi.70241

Matheus Ferreira Linares, Tainá Duarte Dos Santos França, Maria Clara Barros Madureira Ferreira, Michele Gomes do Nascimento, Angela Luzia Branco Pinto Duarte, Luiz Alcino Gueiros

{"title":"Laser Acupuncture on the Management of Xerostomia in Sjögren's Disease: A Randomized Clinical Trial.","authors":"Matheus Ferreira Linares, Tainá Duarte Dos Santos França, Maria Clara Barros Madureira Ferreira, Michele Gomes do Nascimento, Angela Luzia Branco Pinto Duarte, Luiz Alcino Gueiros","doi":"10.1111/odi.70241","DOIUrl":"https://doi.org/10.1111/odi.70241","url":null,"abstract":"Objectives: This study evaluated the efficacy of photobiomodulation (PBM) at acupuncture points for managing xerostomia in patients with Sjögren's Disease.Material and methods: In this randomized, double-blind clinical trial, 50 patients were assigned to PBM group (n = 22) or sham-PBM group (n = 28). The primary outcome was xerostomia symptoms assessed using a visual analogue scale (VAS). Secondary outcomes included Xerostomia Inventory, resting salivary flow rate (RSFR), and EULAR Sjögren's Syndrome Patient Reported Index score. Participants received weekly PBM sessions for four consecutive weeks, and evaluations were conducted at baseline, week 8 and 12.Results: PBM showed a marginal tendency toward improvement on VAS (p = 0.0974) (OR = 1.929 95% CI 0.8939-4.525) and in the RSFR (p = 0.09996) (OR = +infinity 95% CI 0.9363-infinity) at week 8 compared with sham-PBM. However, no statistically significant differences were observed between groups at week 12 for any of the assessed outcomes.Conclusion: PBM at acupuncture points demonstrated a slight short-term benefit at week 8 in improving xerostomia symptoms and RSFR, although these effects did not persist at 12 weeks. These preliminary results suggest a potential role for PBM at acupuncture points as a safe, noninvasive adjunctive therapy for xerostomia in patients with SjD, warranting further validation in larger, long-term trials.Trial registration: This study was registered in The Brazilian Registry of Clinical Trials (U1111-1298-9891).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to Guide Patients Suffering From Periodontitis Towards Behavioural Change: A Systematic Review. 如何引导牙周炎患者改变行为：一项系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-20 DOI: 10.1111/odi.70344

Amandine Quemeneur, Léna Jouan, Hervé Boutigny-Vella, Jean Yves Le Reste, Valérie Chevalier

{"title":"How to Guide Patients Suffering From Periodontitis Towards Behavioural Change: A Systematic Review.","authors":"Amandine Quemeneur, Léna Jouan, Hervé Boutigny-Vella, Jean Yves Le Reste, Valérie Chevalier","doi":"10.1111/odi.70344","DOIUrl":"https://doi.org/10.1111/odi.70344","url":null,"abstract":"Objective: After reviewing the various interventions to evaluate their impact on guiding patients towards plaque control, their effects on periodontitis stabilisation, and the behavioural changes reported by patients.Methods: This PROSPERO-registered systematic review followed PRISMA guidelines. Randomised controlled trials in adults with periodontitis assessing interventions to improve motivation for plaque control were included. Primary outcome was plaque index; secondary outcomes were other periodontal parameters and patient-reported behaviours. Study selection in different databases, data extraction, and risk-of-bias assessment were performed independently by two reviewers.Results: Eight trials were included, with four different motivational interventions. Motivational Interviewing showed positive trends but no significant differences versus control (motivation-method described in the latest recommendations). Behavioural Interventions demonstrated plaque index and probing depth improvements, along with stronger tooth-brushing adherence. Patients included in Individually Tailored Oral Health Educational Programmes showed significantly greater plaque index improvement and maintenance of interdental cleaning versus controls. The Self-Care Commitment Model enhanced plaque control and self-care behaviours, though between-group differences were limited. These last three interventions were multi-sessional. The level of evidence was generally low-to-moderate.Conclusions: Multi-session motivational interventions seemed to have a positive effect for guiding patients towards behavioural changes. Larger and longer-term studies are needed to confirm these findings.Trial registration: PROSPERO registration number: CRD42024551991.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in Chinese Male. 中国男性牙周炎与血清前列腺特异性抗原的相关性研究

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-16 DOI: 10.1111/odi.70324

Yifei Long, Qi Liu, Pengfei Shen, Jun Wang, GuiJun Xue, Chenghao Li

{"title":"Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in Chinese Male.","authors":"Yifei Long, Qi Liu, Pengfei Shen, Jun Wang, GuiJun Xue, Chenghao Li","doi":"10.1111/odi.70324","DOIUrl":"https://doi.org/10.1111/odi.70324","url":null,"abstract":"Objective: This study aimed to clarify the association between periodontitis and prostate-specific antigen and to guide the early prostate-specific antigen screening of periodontitis patients.Materials and methods: 1409 participants who visited West China Hospital of Sichuan University during 2021 and 2022 were included. Measurements were taken for blood pressure, fasting blood glucose, total cholesterol, triglycerides, C-reactive protein, carcinoembryonic antigen, and prostate-specific antigen. Participants went through periodontal examinations and were grouped into non-periodontitis individuals, mild periodontitis, moderate periodontitis, and severe periodontitis. Logistic regression was used to explore the potential associations.Results: Patients with severe periodontitis had significantly higher serum prostate-specific antigen compared to non-periodontitis individuals. No significant association between periodontitis and prostate-specific antigen was found in participants aged 20-40. In patients aged 41-80, regression models showed a significant association between elevated prostate-specific antigen and severe periodontitis, which was not significant in patients with mild and moderate periodontitis.Conclusion: In Chinese men aged 20-80 years, serum prostate-specific antigen was significantly higher in patients with severe periodontitis than in non-periodontitis patients. Severe periodontitis was significantly associated with elevated PSA levels among elder patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa. 大疱性表皮松解症患者脱落的口腔细胞遗传不稳定性增加。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-16 DOI: 10.1111/odi.70316

Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama-de-Souza

{"title":"Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa.","authors":"Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama-de-Souza","doi":"10.1111/odi.70316","DOIUrl":"https://doi.org/10.1111/odi.70316","url":null,"abstract":"Objective: To analyze the nuclear abnormalities of cytotoxicity-karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)-and genotoxicity-micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.Materials and methods: This cross-sectional observational study collected sociodemographic and clinical data through physical examination and a standardized questionnaire. Cells from the buccal, labial, and lingual mucosa were obtained via exfoliative cytology and evaluated for MN, KR, KL, and PN frequencies. Mann-Whitney and Kruskal-Wallis tests were applied.Results: A total of 20 EB individuals were selected. The control group (n = 20) was matched for sex and age with EB. Males (40%) and females (60%) demonstrated a similar distribution and individuals aged ≤ 19 years represented the majority (65%). An increase in KR and KL was detected in EB, with a greater prevalence in the buccal (p = 0.0002 and p < 0.0001) and labial mucosa (p = 0.0005 and p = 0.0240). EB patients showed a higher frequency of MN in the buccal mucosa (p = 0.0083).Conclusion: An increase in nuclear abnormalities at different sites of the oral mucosa demonstrated the genetic instability associated with EB. Exfoliative cytology represents a potential tool for oral biomonitoring in these patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thy1⁺ Periosteal Osteoprogenitors Contribute to Mandibular Bone Defect Healing in Mice. Thy1+骨膜骨祖细胞促进小鼠下颌骨缺损愈合。

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-15 DOI: 10.1111/odi.70309

Linmei Zhang, Wenjing Wu, Jiansheng Su

{"title":"Thy1+ Periosteal Osteoprogenitors Contribute to Mandibular Bone Defect Healing in Mice.","authors":"Linmei Zhang, Wenjing Wu, Jiansheng Su","doi":"10.1111/odi.70309","DOIUrl":"https://doi.org/10.1111/odi.70309","url":null,"abstract":"Objective: To investigate the distribution, lineage fate, and reparative function of Thy1 lineage cells in the mouse mandible.Methods: Single-cell transcriptomic analysis was used to identify osteogenic subpopulations within mandibular mesenchymal stem cells. Lineage tracing in Thy1-CreERT2;Rosa26-tdTomato mice was employed to map the localization and osteogenic contribution of Thy1 lineage cells, while a critical-sized mandibular defect model was established to assess their reparative dynamics. Loss- and gain-of-function experiments were performed using Thy1-CreERT2;Rosa26-DTR mice and transplantation of purified tdTomato+ periosteal cells within hydrogel scaffolds.Results: Single-cell analysis identified a Thy1-enriched osteoprogenitor subpopulation preferentially localized to the periosteum. Lineage tracing revealed that Thy1-lineage cells constituted a major proportion of periosteal osteogenic cells and exhibited clonogenic expansion and ectopic bone formation. Following mandibular injury, tdTomato+ cells progressively accumulated within the callus and represented the predominant osteogenic cell population at later stages. Genetic ablation of Thy1-lineage cells markedly impaired bone repair, whereas transplantation of purified tdTomato+ periosteal cells enhanced bone formation within the defect.Conclusions: Thy1 lineage periosteal cells represent a functionally important osteoprogenitor population in mandibular bone regeneration, providing a cellular framework for future mechanistic and translational studies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of a Hyaluronic Acid-Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A Single-Blind Randomized Clinical Trial. 透明质酸凝胶与0.20%氯己定在牙周非手术治疗中的疗效：一项单盲随机临床试验

IF 2.9 3区医学

Oral diseases Pub Date : 2026-04-15 DOI: 10.1111/odi.70345

Andrea Scribante, Maurizio Pascadopoli, Matteo Pellegrini, Karyna Chekal, Andrea Butera

{"title":"Efficacy of a Hyaluronic Acid-Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A Single-Blind Randomized Clinical Trial.","authors":"Andrea Scribante, Maurizio Pascadopoli, Matteo Pellegrini, Karyna Chekal, Andrea Butera","doi":"10.1111/odi.70345","DOIUrl":"https://doi.org/10.1111/odi.70345","url":null,"abstract":"Objective: To compare the adjunctive efficacy of a hyaluronic acid (HA) gel with 0.20% chlorhexidine (CHX) during nonsurgical periodontal therapy in periodontal patients over 6 months.Methods: A single-blind, randomized, controlled trial included 40 healthy, nonsmoking adults with periodontitis. After supra- and subgingival debridement, patients used either HA gel (Aftoral; hyaluronic acid with glycerophosphoinositol and xylitol) or CHX mouthwash (Unidea; 0.20% chlorhexidine digluconate) once daily for 15 days at each time recall appointment. Clinical parameters-probing pocket depth (PPD, primary outcome), plaque control record (PCR), bleeding on probing (BoP), gingival recession (GR), tooth mobility (TM), clinical attachment level (CAL), and satisfaction (VAS)-were measured at baseline, 1, 3, and 6 months by a blinded examiner. Nonparametric tests were applied with significance at p < 0.05.Results: HA showed greater PPD reduction than CHX at 3 and 6 months (-0.44 mm vs. -0.26 mm; p < 0.01). PCR and BoP decreased more in the HA group (p < 0.05), while CAL gain was higher (-0.43 mm vs. -0.21 mm; p < 0.05). GR, TM, and VAS showed no differences. No adverse events occurred.Conclusions: Adjunctive HA gel improved PPD, PCR, BoP, and CAL compared with CHX, confirming safety, and clinical benefit.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0