Oral diseases最新文献_第2页

Intraparotid Facial Nerve Schwannoma: A Comprehensive Review of 70 Cases at One Single Institution. 腮腺内面神经鞘瘤：对同一医院70例病例的综合分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-24 DOI: 10.1111/odi.15323

Lingli Huang, Wei Xu, Wenya Zhu, Hao Lu, Shengwen Liu, Wenjun Yang, Wanlin Xu

{"title":"Intraparotid Facial Nerve Schwannoma: A Comprehensive Review of 70 Cases at One Single Institution.","authors":"Lingli Huang, Wei Xu, Wenya Zhu, Hao Lu, Shengwen Liu, Wenjun Yang, Wanlin Xu","doi":"10.1111/odi.15323","DOIUrl":"https://doi.org/10.1111/odi.15323","url":null,"abstract":"Objective: The current study aimed to analyze the clinical characteristics, diagnosis, and surgical outcomes of intraparotid facial nerve schwannoma (IPFNS) and propose a more definitive therapeutic algorithm for IPFNS.Methods: Between January 2018 and December 2023, all the cases of IPFNS at our single institution were retrospectively reviewed.Results: In total, 70 patients were included in this study. Among them, 23 (32.3%) were men and 47 (67.7%) were women. The patients commonly presented with a painless parotid mass, and three patients complained of facial paralysis. Magnetic resonance imaging (MRI) had the highest diagnostic efficacy (37.1%) among all the evaluation techniques used. Marchioni's classification and surgical method were significantly associated with postoperative facial function. In terms of surgical interventions, stripping surgery was suitable for type A tumors, while for types B, C, and D tumors, intracapsular enucleation with a microscope was recommended to decrease the influence of the procedure on facial nerve function.Conclusions: IPFNS is a rare disease, whose diagnosis and management remain challenging. MRI is the preferred preoperative diagnostic method. Preoperative facial nerve function, tumor location, and patients' preferences are key factors in the decision-making process of IPFNS treatment.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rb3 Inhibits Oxidative Stress and Alleviates Experimental Periodontitis in Rats. 人参皂苷Rb3抑制氧化应激，减轻实验性牙周炎。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-24 DOI: 10.1111/odi.15318

Xin Meng, Huijuan Qu, Xueying Zhang, Honghai Ji, Minmin Sun

{"title":"Ginsenoside Rb3 Inhibits Oxidative Stress and Alleviates Experimental Periodontitis in Rats.","authors":"Xin Meng, Huijuan Qu, Xueying Zhang, Honghai Ji, Minmin Sun","doi":"10.1111/odi.15318","DOIUrl":"https://doi.org/10.1111/odi.15318","url":null,"abstract":"Objective: This study investigated the anti-inflammatory and antioxidative effects of ginsenoside Rb3 on experimental periodontitis.Methods: Experimental periodontitis was established by ligating the maxillary first molars. After 21 days of Rb3 treatment, rats were sacrificed for micro-CT and H&E staining analysis and serum assay. qPCR detected the expression of inflammatory genes. IF detected MAPKs pathway activation in periodontal tissues. The effects were determined using LPS-induced RAW264.7 cells. Gene expression levels were determined by qPCR. Intracellular ROS generation was detected by DCFH-DA staining and flow cytometry. WB detected the activation of signaling pathways.Results: Rb3 inhibited oxidative stress in experimental periodontitis, showing reduced gingivitis and alveolar bone resorption on H&E staining and micro-CT, and reduced iNOS mRNA in rats. Colorimetric results showed that Rb3 increased serum SOD and GSH-Px activities and decreased MDA levels in rats. IF analysis showed that Rb3 inhibited P38, ERK, and JNK activation. Rb3 pretreatment significantly decreased iNOS and IL-6 mRNA expression and ROS in Raw264.7 cells. WB analysis demonstrated that Rb3 blocked the activation of P38 and ERK.Conclusion: Rb3 inhibits the level of oxidative stress and attenuates gingivitis and alveolar bone resorption in rats via the MAPKs signaling pathway.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Surgical and Non-Surgical Periodontal Therapy on Quality of Life in Case of Periodontitis. 牙周炎手术与非手术治疗对患者生活质量的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-19 DOI: 10.1111/odi.15316

Aliye Gerzile, Yonca Naziker, Ece Özer, Abdullah Seckin Ertugrul

{"title":"Impact of Surgical and Non-Surgical Periodontal Therapy on Quality of Life in Case of Periodontitis.","authors":"Aliye Gerzile, Yonca Naziker, Ece Özer, Abdullah Seckin Ertugrul","doi":"10.1111/odi.15316","DOIUrl":"https://doi.org/10.1111/odi.15316","url":null,"abstract":"Objective: This study aims to evaluate the status of periodontitis patients and changes in their quality of life (QoL) after non-surgical and surgical periodontal treatment using OHIP-14, OHRQoL-UK questionnaires, and VAS.Methods: Of the 50 periodontitis patients included in the study, 27 received only non-surgical treatment. The remaining 23 individuals received additional surgical treatment because full recovery was not achieved with non-surgical periodontal treatment. OHIP-14, OHRQoL-UK questionnaires, and VAS were administered to these patients before periodontal treatment and after (4th and 12th weeks) to assess QoL measurements.Results: OHRQoL-UK results found that there was a statistically significant increase in the 3rd month (T2) values after the flap operation compared to the initial session (T0) (p < 0.05). Compared to non-surgical periodontal treatment (T1) with T2, the difference was not statistically significant except in the pain/discomfort category (p > 0.05). Although the results of the OHIP-14 questionnaire at T1 and T2 showed a significant difference compared to T0 values (p < 0.05), no significant difference was found between T1 and T2 (p > 0.05). An increase in some values was observed in VAS results compared to T0, but it was not significant (p > 0.05).Conclusions: VAS, OHIP-14, and OHRQoL-UK questionnaires have shown that periodontal treatment improves the QoL of patients with periodontitis.Trial registration: ClinicalTrials.gov identifier: NCT06539364.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions. 口腔癌和癌前病变的微生物组特征和生态失调模式。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-19 DOI: 10.1111/odi.15317

Cheng-Chieh Yang, Jumpei Washio, Yu-Cheng Lin, Ming-Lun Hsu, Ding-Han Wang, Fa-Tzu Tsai, Yu-Min Lin, Hsi-Feng Tu, Hsiu-Chuan Chang, Nobuhiro Takahashi

{"title":"Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions.","authors":"Cheng-Chieh Yang, Jumpei Washio, Yu-Cheng Lin, Ming-Lun Hsu, Ding-Han Wang, Fa-Tzu Tsai, Yu-Min Lin, Hsi-Feng Tu, Hsiu-Chuan Chang, Nobuhiro Takahashi","doi":"10.1111/odi.15317","DOIUrl":"https://doi.org/10.1111/odi.15317","url":null,"abstract":"Background: The oral microbiome has been shown to be associated with the development of oral squamous cell carcinoma (OSCC). Research has primarily focused on elucidating the oncogenic mechanisms of specific pathogens by comparing the microbiomes of OSCC and normal tissues. However, the characteristics of the microbiome in the precancerous state remain less understood, as does the influence of metabolic and environmental factors on OSCC-associated microbiomes.Methods: In this study, we analyzed mucosa-associated microbiomes in normal, precancerous, and OSCC lesions from a cohort of 51 patients using 16S rRNA amplicon sequencing. We investigated compositional changes in the microbiome, including the specific abundances and co-occurrences of OSCC-associated bacteria.Results: Our findings indicate that the microbiome associated with precancerous lesions is indistinguishable from that of the normal mucosa, whereas the OSCC microbiome significantly differs from both normal and precancerous conditions. Specifically, the OSCC microbiome harbors less Streptococcus, coupled with an increase in amino-acid-degrading anaerobes such as Fusobacterium and Prevotella. The metabolic properties of individual microbes reported suggest that the overrepresentation of OSCC-specific bacteria is a result of metabolic adaptation to tumor microenvironments, although this possibility needs to be experimentally confirmed.Conclusions: Our results demonstrate oral microbiome patterns across OSCC progression, offering insights into microbial ecological perspectives.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teleconsultation Actions in Reducing In-Person Referrals for Oral Lesions: A Scoping Review. 远程会诊在减少口腔病变现场转诊中的作用：范围综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-18 DOI: 10.1111/odi.15314

Rebeka Thiara Nascimento Dos Santos, Jonathan França da Silva Cavalcanti, Luiz Gustavo de Sousa Duda Júnior, Ana Júlia Alves de Vasconcelos, Pamella Recco Alvares, Ana Paula Veras Sobral

{"title":"Teleconsultation Actions in Reducing In-Person Referrals for Oral Lesions: A Scoping Review.","authors":"Rebeka Thiara Nascimento Dos Santos, Jonathan França da Silva Cavalcanti, Luiz Gustavo de Sousa Duda Júnior, Ana Júlia Alves de Vasconcelos, Pamella Recco Alvares, Ana Paula Veras Sobral","doi":"10.1111/odi.15314","DOIUrl":"https://doi.org/10.1111/odi.15314","url":null,"abstract":"Objectives: This scoping review aimed to investigate the impact of teleconsultation actions on the reduction of unnecessary referrals for specialized in-person care of oral lesions.Materials and methods: This review included studies on teleconsultation in oral medicine and oral pathology that presented data on the referral flow for in-person care. Teleconsultation modalities included synchronous, asynchronous, or unspecified interactions. Excluded from the review were: (1) reviews, clinical cases, letters, chapters, conference abstracts, and editorials; (2) studies on direct teleconsultation between professionals; (3) telemanagement interventions; and (4) tele-education initiatives.Results: Nine articles met the inclusion criteria. The asynchronous teleconsultation stands out as the most effective intervention for reducing in-person referrals, observed in eight studies. Referral reductions ranged from 37.3% to 80%, with five studies exceeding 50%. Primary healthcare dentists were the most frequent users of the teleconsultation platform. The most commonly identified lesions found were oral potentially malignant disorders and soft tissue tumors.Conclusion: Asynchronous teleconsultation may reduce referrals for in-person care, though evidence is limited. Notably, referral rates exhibited significant heterogeneity across studies. Low reduction rates may be attributed to the high proportion of cases requiring in-person assessment. Future research should focus on optimizing referral reduction while addressing the heterogeneity of outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Dental Status of Patients Taking Common Biologic Agents: A Single-Center Cross-Sectional Study. 服用常用生物制剂患者的牙齿状况：一项单中心横断面研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-17 DOI: 10.1111/odi.15311

Shivani Shah, Nila Veerabagu, Nana A A Essel, Neda Mahjour, Katherine France

{"title":"The Dental Status of Patients Taking Common Biologic Agents: A Single-Center Cross-Sectional Study.","authors":"Shivani Shah, Nila Veerabagu, Nana A A Essel, Neda Mahjour, Katherine France","doi":"10.1111/odi.15311","DOIUrl":"https://doi.org/10.1111/odi.15311","url":null,"abstract":"Objectives: Despite expanding use and medical applications, little is known about the impact of biologic agents (BAs) on dental treatment. The aim of this study was to investigate the dental status of patients on common classes of BAs to understand treatment needs and use in this population.Methods: A retrospective cross-sectional study was conducted on patients treated with the most common classes of BA (tumor necrosis factor-alpha [TNF-α] inhibitors, interleukin (IL) inhibitors, and lymphocyte modulators) from 1/7/2017 to 1/7/2022. Data on demographic factors, BA treatment, medical conditions including indication, restorative and periodontal treatments, and decayed, missing, and filled tooth index (DMFT) were compared descriptively.Results: The study identified 247 patients treated with 24 different BAs. Restorative and periodontal treatment was completed on 60.3% and 72.9% of patients, respectively. The DMFT scores were higher in the study cohort compared to the average US adult population. The analysis revealed an upward trend in both periodontal and restorative treatments.Conclusions: This study provides the first comprehensive characterization of the oral health status and treatment needs of patients taking BAs. The findings suggest a higher dental treatment burden in this population, particularly regarding restorative care in this population, a finding that may be confirmed or expanded in future evaluations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postgraduate Satisfaction in Oral Pathology and Oral Medicine: Insights From Brazil. 口腔病理学和口腔医学研究生的满意度：巴西的启示

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-17 DOI: 10.1111/odi.15315

Luiz Miguel Ferreira, Marcos Paulo Maia-Lima, Samuel Trezena, Fabrício Emanuel Soares de Oliveira, Árlen Almeida Duarte, Daniella Reis Barbosa Martelli, Fábio de Abreu Alves, Roseana de Almeida Freitas, Jean Nunes Dos Santos, Maria Cassia Ferreira de Aguiar, Marcio Ajudarte Lopes, Paulo Rogério Ferreti Bonan, Janete Dias Almeida, Hercílio Martelli-Júnior

引用次数: 0

Development of the Multidimensional Scale Related to Infectious Diseases in Dentistry. 牙科传染病多维度量表的研制

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-17 DOI: 10.1111/odi.15302

Daniele Sorgatto Faé, Francielle Silvestre Verner, Cleidiel Aparecido Araujo Lemos, Rafael Binato Junqueira, Rodrigo Furtado de Carvalho, Pedro Henrique Berbert de Carvalho, Sibele Nascimento de Aquino

{"title":"Development of the Multidimensional Scale Related to Infectious Diseases in Dentistry.","authors":"Daniele Sorgatto Faé, Francielle Silvestre Verner, Cleidiel Aparecido Araujo Lemos, Rafael Binato Junqueira, Rodrigo Furtado de Carvalho, Pedro Henrique Berbert de Carvalho, Sibele Nascimento de Aquino","doi":"10.1111/odi.15302","DOIUrl":"https://doi.org/10.1111/odi.15302","url":null,"abstract":"Objective: This study aimed to develop and validate an instrument to assess dentists' adherence to infection control protocols and explore psychological factors related to infectious diseases in dental practice.Materials and methods: The instrument was developed through phases including context validity, face and semantic analysis, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). Internal consistency was evaluated using McDonald's Omega coefficient (ω) and Cronbach's Alpha (α).Results: A total of 405 individuals completed the instrument. EFA (n = 135) revealed a four-factor structure (Work Environmental Protection, Disinfection, Team Training, and Fear and Anxiety) with 23 items with factor loadings above 0.60. The Kaiser-Meyer-Olkin (KMO) value was 0.803, and Bartlett's test of sphericity was significant (χ2: 2501.136, df:253.000, p < 0.001). CFA (n = 270) confirmed an acceptable model fit: χ2/df: 1.75; Comparative Fit Index (CFI): 0.997; Tucker-Lewis Index (TLI): 0.996; Standardized Root Mean Square Residual (SRMR): 0.079; Root Mean Square Error of Approximation (RMSEA): 0.053, supporting the four-factor structure from the EFA. Reliability analysis demonstrated strong internal consistency across all factors (ω and α ≥ 0.70).Conclusion: The developed instrument exhibited appropriate validity, reliability, and internal consistency, providing a suitable tool to evaluate infection control adherence and psychological aspects among dentists facing infectious diseases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferroptosis: A New Challenge and Target in Oral Diseases. 上睑下垂：口腔疾病的新挑战和新目标。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-17 DOI: 10.1111/odi.15303

Ruijie Jiao, Hu Long

{"title":"Ferroptosis: A New Challenge and Target in Oral Diseases.","authors":"Ruijie Jiao, Hu Long","doi":"10.1111/odi.15303","DOIUrl":"https://doi.org/10.1111/odi.15303","url":null,"abstract":"Objective: Ferroptosis, an iron-dependent intracellular programmed cell death mechanism discovered in the last decade, has emerged as a novel and intriguing concept in oral diseases, distinct from apoptosis, necrosis, and pyroptosis. This process plays a critical role in the pathophysiology of inflammation, trauma, and tumors, with evidence of its presence in multiple organ systems, including the liver, kidneys, and heart. In recent years, many studies have found that ferroptosis is closely related to oral diseases, and a number of pathogenic pathways and therapeutic strategies have been reported. However, ferroptosis remains an underexplored area in oral diseases, with multiple secrets waiting to be uncovered.Method: We collected articles related to ferroptosis and oral diseases and analyzed the mechanisms and therapeutic strategies associated with ferroptosis in different oral diseases.Results: In this review, we present a comprehensive analysis of ferroptosis and oral diseases, emphasizing its core mechanisms and associated therapeutic approaches. Furthermore, we give an outlook for future explorations of ferroptosis related to oral diseases.Conclusion: This review provides dental researchers and clinicians with a current state of ferroptosis in oral diseases, thereby inspiring noval investigations and discoveries.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to Treatment Initiation of Oral Cancer: Impact of a National Policy in Midwest Brazil. 口腔癌开始治疗的时间：巴西中西部国家政策的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-17 DOI: 10.1111/odi.15313

Mary Anne de Souza Alves França, Rejane Faria Ribeiro-Rotta, Nádia do Lago Costa, Patrícia Corrêa-Faria, Gabriela Moreira Policena, Maria do Carmo Matias Freire

引用次数: 0