Oral diseases最新文献_第2页

Metabolic Analysis of Tumor Cells Within Ameloblastoma at the Single-Cell Level.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-31 DOI: 10.1111/odi.15239

Rui-Fang Li, Yi Zhao, Qi-Wen Man

{"title":"Metabolic Analysis of Tumor Cells Within Ameloblastoma at the Single-Cell Level.","authors":"Rui-Fang Li, Yi Zhao, Qi-Wen Man","doi":"10.1111/odi.15239","DOIUrl":"https://doi.org/10.1111/odi.15239","url":null,"abstract":"Background: To meet their high energy needs, tumor cells undergo aberrant metabolic reprogramming. A tumor cell may expertly modify its metabolic pathways and the differential expression of the genes for metabolic enzymes. The physiological requirements of the host tissue and the tumor cell of origin mostly dictate metabolic adaptation. Ameloblastoma (AB) is a benign odontogenic tumor of epithelial origin. Due to its unrestricted growth potential, local aggressiveness, and high likelihood of recurrence, this condition poses a significant risk to the patient's health. This study aimed to characterize the metabolic heterogeneity at single-cell resolution of AB.Methods: Single-cell RNA sequencing (scRNA-seq) was performed on 17,284 cells from three AB donors. Bioinformatic analysis was used to examine differentially expressed genes, subtypes, and regulatory mechanisms when combined with odontogenic keratocyst scRNA-seq data. Based on metabolic pathway gene sets, the metabolic landscape of AB tumor cells was examined.Results: Using scRNA-seq, we discovered that AB tumor cells had substantial heterogeneity. The biggest contributor to tumor cell metabolic characteristics is determined to be variation in mitochondrial programming and glycolysis. Surprisingly, hypoxia corresponds with both oxidative phosphorylation and glycolysis activity in AB tumor cells at the single-cell level.Conclusion: This study presents a computational framework for defining metabolism using single-cell expression data and identifies oxidative phosphorylation and glycolysis as critical components of metabolism for AB tumor cells.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Conservative Therapy in Juvenile Recurrent Parotitis: A Retrospective Study. 青少年复发性腮腺炎的保守疗法疗效：回顾性研究

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15240

Yanxiang Li, Shutong Niu, Zhiyuan He, Hanyi Zhu, Yimin Liu, Xin Bao, Chuangqi Yu, Huan Shi

{"title":"Efficacy of Conservative Therapy in Juvenile Recurrent Parotitis: A Retrospective Study.","authors":"Yanxiang Li, Shutong Niu, Zhiyuan He, Hanyi Zhu, Yimin Liu, Xin Bao, Chuangqi Yu, Huan Shi","doi":"10.1111/odi.15240","DOIUrl":"https://doi.org/10.1111/odi.15240","url":null,"abstract":"Objective: The objective of this study is to evaluate the therapeutic effect of conservative treatment in children with juvenile recurrent parotitis (JRP).Methods: Clinical data from 55 children who were diagnosed with JRP from June 2019 to January 2022 were collected. On admission, patients underwent comprehensive examinations, and a questionnaire was completed by the patients and their parents. Patients received only conservative treatment, including sialagogues, warm compresses, massage and antibiotic treatment.Results: Episodes after treatment (1.11 ± 1.42) were significantly lower in 55 patients than before treatment (3.35 ± 2.42) (p < 0.001). Clinical symptoms improved for 81.81% and recurred for 60%. Patients who did not respond to treatment were in 3- to 5-year-old group. The serum IgG (p = 0.018), IgA (p = 0.014) and IgM (p = 0.032) levels in the nonresponsive group were significantly higher than those in the improvement group and were either higher than the normal range or at the upper limit. The improvement rate was positively related to the CD8%, and the serum IgA concentration was negatively related to the number of previsit episodes.Conclusion: Conservative treatment is effective for most children with JRP. Patient responses to treatment may be associated with the maturation of their immune systems. Underlying immune dysregulation should be evaluated, and further treatment is needed in severe cases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction Between Sclerostin and Mast Cells in Fibro-Osseous Lesions of the Jaws. 颌骨纤维骨化病变中硬骨素与肥大细胞之间的相互作用

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15232

Riéli Elis Schulz, Michel Calil Abrão-Neto, Thiago Pires Claudio, Vinícius Gonçalves de Souza, Elena Riet Correa Rivero, Rogério Oliveira Gondak, Gustavo Davi Rabelo

{"title":"Interaction Between Sclerostin and Mast Cells in Fibro-Osseous Lesions of the Jaws.","authors":"Riéli Elis Schulz, Michel Calil Abrão-Neto, Thiago Pires Claudio, Vinícius Gonçalves de Souza, Elena Riet Correa Rivero, Rogério Oliveira Gondak, Gustavo Davi Rabelo","doi":"10.1111/odi.15232","DOIUrl":"https://doi.org/10.1111/odi.15232","url":null,"abstract":"Objective: To assess the sclerostin, β-catenin, and tryptase expression in fibro-osseous lesions (FOL) of the jaws.Subjects and methods: Immunohistochemistry analysis was performed for these proteins on FOL and non-lesional bone. The sclerostin-positive cells were scored from 0 (no expression) to 3 (high expression).Results: We analyzed 46 FOL biopsies and selected 38 patients. Categorization showed 15 fibrous dysplasia (FD), eight juvenile trabecular ossifying fibroma (JTOF), two psammomatoid ossifying fibroma (PsOF), and 13 FOL. We found more sclerostin-positive cells in fibrous tissue than in bone, showing a phenotype like mast cells with strong dot-cytoplasmic positivity. The analysis of sclerostin-positive cell lesions (scored as 2 and 3) showed also tryptase positivity in 80.9% of 21 biopsies. β-catenin was diffusely expressed on the fibrous component, mostly with cytosol staining. Non-lesional bone showed sclerostin expression in medullary spaces and a few osteocytes.Conclusions: Sclerostin-positive cells are mostly found in the fibrous tissue of FOL, and the tryptase mast cell marker was present in most of the lesions that were positive for sclerostin.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Oral Inflammatory Burden on Size and Stage of Oral Tongue Cancer. 口腔炎症负担对口腔舌癌大小和分期的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15227

Orvokki Saraneva, Jussi Furuholm, Jaana Hagström, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Välimaa, Hellevi Ruokonen

{"title":"Effect of Oral Inflammatory Burden on Size and Stage of Oral Tongue Cancer.","authors":"Orvokki Saraneva, Jussi Furuholm, Jaana Hagström, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Välimaa, Hellevi Ruokonen","doi":"10.1111/odi.15227","DOIUrl":"https://doi.org/10.1111/odi.15227","url":null,"abstract":"Objective: Oral tongue squamous cell carcinoma is an aggressive life-threatening disease, the prognosis of which is affected by tumor stage and size. We retrospectively studied whether oral inflammatory burden and established tongue carcinoma etiological factors exert an impact on tumor size and stage.Materials and methods: Medical records of 183 subjects diagnosed with tongue carcinoma at Helsinki University Hospital were investigated. Data on sex, smoking habits, alcohol consumption, and oral inflammatory burden were assessed by the Periodontal Burden Index, Total Dental Index, and Panorama Tomography Index. In addition, Candida hyphae in histological samples, and tumor size and stage were recorded and analyzed. History of oral potentially malignant disorders was also investigated.Results: Increased oral inflammatory burden, male sex, and smoking were associated significantly with larger size and advanced stage of cancer, whereas oral Candida hyphae were not associated with size of tongue carcinoma but were associated with female sex.Conclusion: Male sex, oral inflammatory burden, and smoking were more common in patients with a large and advanced stage of tongue carcinoma. Thus, oral and periodontal infections and their pro-inflammatory effects may eventually promote carcinoma growth and advance the stage, especially in males.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cone Beam CT Sialography for the Assessment of Submandibular Gland Structure in Diabetes Mellitus.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15244

Muhammed Akif Sümbüllü, Kübra Başaran Aslan, Fatma Çağlayan

{"title":"Cone Beam CT Sialography for the Assessment of Submandibular Gland Structure in Diabetes Mellitus.","authors":"Muhammed Akif Sümbüllü, Kübra Başaran Aslan, Fatma Çağlayan","doi":"10.1111/odi.15244","DOIUrl":"https://doi.org/10.1111/odi.15244","url":null,"abstract":"Objective: To examine the anatomical and morphological structure and potential pathological conditions of the submandibular gland by performing Cone Beam Computed Tomography (CBCT) sialography in patients with diabetes mellitus.Study design: The submandibular salivary glands of 25 diabetic and 25 healthy volunteers were examined by CBCT sialography. The images were evaluated to determine the main and lateral canals, the diameter of the main canal, the presence of ductal stenosis, central ductal dilatation, acinar pooling, the presence of sialoliths, and the visualization of the main and lateral canals and parenchyma.Results: There was no statistically significant difference between the patients and controls in the diameters of the primary ducts of submandibular glands and the visibility of secondary and tertiary ducts, sialoliths, ductal stenosis, and acinar pooling (p > 0.05). Nevertheless, ductal dilatation and the location of ductal dilatation were statistically more prevalent in diabetic patients (p = 0.01 and p < 0.05, respectively).Conclusion: The prevalence of sialolith, ductal stenosis, and peripheral ductal dilatation was higher among diabetic patients than in the control group, although this difference was not statistically significant. However, ductal dilatation was observed to be statistically significantly more prevalent in diabetics. CBCT sialography proved to be a valuable tool for demonstrating parenchymal changes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women Who are Productivity Scholarship Holders in Brazil Published Lower Number of Articles Than Men. 巴西生产率奖学金获得者中的女性发表的文章数量低于男性。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15237

Laura Barreto Moreno, Pedro Paulo de Almeida de Dantas, Anelise Fernandes Montagner, Francisco Wilker Mustafa Gomes Muniz

引用次数: 0

The Critical Role of Polyphenols in Immunomodulation and Periodontal Regeneration.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15245

Mingyu Zhao, Peitong Li, Xudong Xie, Peilei Shi, Qianting Wang, Jun Wang, Chunmei Xu

{"title":"The Critical Role of Polyphenols in Immunomodulation and Periodontal Regeneration.","authors":"Mingyu Zhao, Peitong Li, Xudong Xie, Peilei Shi, Qianting Wang, Jun Wang, Chunmei Xu","doi":"10.1111/odi.15245","DOIUrl":"https://doi.org/10.1111/odi.15245","url":null,"abstract":"Objectives: Periodontitis, the main cause of tooth loss in adults, is a widespread oral disease characterized by chronic inflammation primarily triggered by periodontopathic bacterial infection. Polyphenols are a class of compounds extracted from herbs and diets, characterized by the presence of more than one phenol unit per molecule. Emerging evidence has revealed that polyphenols show significant effectiveness in ameliorating tissue destruction in periodontitis. Herein, we comprehensively review current literature studying the critical role of polyphenols in periodontitis and summarize the predominant molecular mechanisms in immunomodulation and periodontal regeneration, aiming to provide a better understanding of their therapeutic potential in periodontitis.Methods: PubMed and Web of Science databases were searched for articles, reviews, and clinical studies published until August 2024.Results: We summarized the immunomodulatory effects of polyphenols in vivo and in vitro, described the research advance regulating the functions of periodontal ligament stem cells and their regeneration potential, and discussed the underlying mechanisms. Finally, we propose future directions for periodontitis therapies with polyphenols.Conclusions: Polyphenols exert a significant anti-inflammatory effect and promising potential to promote periodontal regeneration. Further study of the molecular mechanisms and techniques to increase the bioavailability and effect of polyphenols is warranted.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Influence of Birth Month on the Incidence of Burning Mouth Syndrome. 调查出生月份对烧嘴综合征发病率的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15236

Takayuki Suga, Chihiro Takao, Takahiko Nagamine, Akira Toyofuku

引用次数: 0

Comment on: Surgical Treatment Compared With "Wait and See" in Patients Affected by Oral Leukoplakia to Prevent Oral Cancer: Preliminary Data From a Multicenter Randomized Controlled Trial.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15230

Wei Liu, Xuemin Shen, Linjun Shi

引用次数: 0

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15235

Pepijn J P van der Aa, Max J H Witjes, Bert van der Vegt, Ed Schuuring, Koos Boeve, Grigory Sidorenkov, Geertruida H de Bock, Sebastiaan A H J de Visscher

{"title":"Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours.","authors":"Pepijn J P van der Aa, Max J H Witjes, Bert van der Vegt, Ed Schuuring, Koos Boeve, Grigory Sidorenkov, Geertruida H de Bock, Sebastiaan A H J de Visscher","doi":"10.1111/odi.15235","DOIUrl":"https://doi.org/10.1111/odi.15235","url":null,"abstract":"Objectives: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).Materials and methods: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).Results: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).Conclusion: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0