Oral diseases最新文献_第2页

Cost of Illness Study on Oral Cancer in Australia.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-23 DOI: 10.1111/odi.15267

M A B Gama, U Tonmukayakul, N Saraswat, N McCaffrey, T M Nguyen

{"title":"Cost of Illness Study on Oral Cancer in Australia.","authors":"M A B Gama, U Tonmukayakul, N Saraswat, N McCaffrey, T M Nguyen","doi":"10.1111/odi.15267","DOIUrl":"https://doi.org/10.1111/odi.15267","url":null,"abstract":"Objectives: The aim of this study is to estimate the economic burden of oral cancer in Australia from the societal perspective.Methods: The population consisted of the prevalence of lip and oral cavity cancer, and other lip, oral cavity, and pharynx cancers for ages 40 years and older. Healthcare costs of oral cancer were estimated using 2019-2020 Australian Disease Expenditure Data. Productivity losses were estimated using disability-adjusted life years, derived from the 2019 Global Burden of Disease Study and 2019 Australian gross domestic product per capita.Results: The estimated annual healthcare costs for oral cancer in Australia were approximately AUD$113.2 million. Over half of the total healthcare costs (54%) were attributable to public hospital admissions (AUD$61.2 million), followed by private hospital services (28%) and pharmaceutical benefits (8%). The total costs, including healthcare and productivity losses, were around AUD$2.1 billion. The productivity losses due to oral cancer were higher for males compared to females (AUD$1.5 billion versus AUD$0.6 billion).Conclusions: The study reveals a significant economic burden of oral cancer for 2019 in Australia at AUD$2.1 billion, largely due to productivity losses and public hospital admissions. This highlights the need for effective screening and prevention programs.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LIMA1 Is a Prognostic Senescence-Inhibitory Gene in Head and Neck Squamous Carcinoma. LIMA1是头颈部鳞状癌的预后衰老抑制基因。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-21 DOI: 10.1111/odi.15263

Yuanhe You, Zhong Du, Zhuowei Tian, Fan Yu, Shunshun Li, Jie He, Meng Xiao, Yanan Wang

{"title":"LIMA1 Is a Prognostic Senescence-Inhibitory Gene in Head and Neck Squamous Carcinoma.","authors":"Yuanhe You, Zhong Du, Zhuowei Tian, Fan Yu, Shunshun Li, Jie He, Meng Xiao, Yanan Wang","doi":"10.1111/odi.15263","DOIUrl":"https://doi.org/10.1111/odi.15263","url":null,"abstract":"Background: This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head and neck squamous cell carcinoma.Methods: Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) and the Human Aging Genomic Resources (HAGR) database. Prognostic value and immune infiltration were assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK-8, Edu assay, and colony formation assays in vitro. Western blotting and real-time PCR were used to evaluate LIMA1 expression. Clinical validation of LIMA1 expression was performed in our validated cohort.Results: In this study, differential analysis and functional enrichment analysis identified 26 differentially expressed senescence inhibitory genes. Among them, LIMA1 was found to be an independent prognostic marker and associated immune infiltration. Knockdown of LIMA1 inhibited HNSCC cell growth and increased the expression of senescence markers. Further experiments revealed that LIMA1 expression was partially regulated by the IL6/STAT3 signaling pathway. Immunohistochemistry further validated the clinical significance of LIMA1 expression and its association with IL6 and CD8+ T cells in our hospital's HNSCC tissues.Conclusion: LIMA1 is a prognostic senescence-inhibitory gene in HNSCC. The IL6/STAT3/LIMA1 axis represents a novel molecular mechanism underlying cellular senescence resistance in HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply "Effect of Adiposity Status on Salivary Streptococcus mutans and Streptococcus sobrinus." Oral Diseases. Advance Online Publication. https://doi.org/10.1111/odi.15111. 作者回复“肥胖状况对唾液变形链球菌和链球菌的影响”口腔疾病。提前在线出版。https://doi.org/10.1111/odi.15111。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-17 DOI: 10.1111/odi.15261

Qianyi Deng, Hai Ming Wong, Simin Peng

引用次数: 0

Assessment of Surgical Margin of Tongue Squamous Cell Carcinoma via Raman Mapping. 用拉曼成像评价舌鳞癌的手术切缘。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-15 DOI: 10.1111/odi.15231

Zhongxu Li, Lili Xue, Xiaobo Dai, Zhixin Li, Zhenxin Wu, Yi Li, Bing Yan

{"title":"Assessment of Surgical Margin of Tongue Squamous Cell Carcinoma via Raman Mapping.","authors":"Zhongxu Li, Lili Xue, Xiaobo Dai, Zhixin Li, Zhenxin Wu, Yi Li, Bing Yan","doi":"10.1111/odi.15231","DOIUrl":"https://doi.org/10.1111/odi.15231","url":null,"abstract":"Objectives: This study introduces a novel classification approach that combines convolutional neural network (CNN) and Raman mapping to differentiate between tongue squamous cell carcinoma (TSCC) and non-tumorous tissue, as well as to identify different histological grades of TSCC.Materials and methods: In this study, 240 Raman mappings data from 30 tissue samples were collected from 15 patients who had undergone surgical resection for TSCC. A total of 18,000 sub-mappings extracted from Raman mappings were then used to train and test a CNN model, which extracted feature representations that were subsequently processed through a fully connected network to perform classification tasks based on the Raman mapping data.Results: The experimental results indicated that the proposed method achieved competitive classification accuracy above 83%. To further validate the effectiveness of the Raman mapping, its performance was compared with Raman spectroscopy, demonstrating a competitive accuracy rate.Conclusions: The promising outcomes from this application of CNN in Raman mapping suggest that this technique could be a reliable method for intraoperative assessment of surgical margins, potentially leading to shorter detection times.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Recurrent Oral Ulcer on a Man's Tongue". 评论“男性舌部复发性口腔溃疡”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15257

Heitor Albergoni Silveira, Jorge Esquiche León

引用次数: 0

Simplified Jaw Functional Limitation Scale for Temporomandibular Disorders: Psychometric Evaluation. 颞下颌障碍的简化颌功能限制量表：心理测量评估。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15253

Ruonan Sun, Tiqian Liu, Yiwei Liu, Shuyuan Zhang, Yuan Yue, Nan Jiang, Liming Zhang, Xin Xiong

{"title":"Simplified Jaw Functional Limitation Scale for Temporomandibular Disorders: Psychometric Evaluation.","authors":"Ruonan Sun, Tiqian Liu, Yiwei Liu, Shuyuan Zhang, Yuan Yue, Nan Jiang, Liming Zhang, Xin Xiong","doi":"10.1111/odi.15253","DOIUrl":"https://doi.org/10.1111/odi.15253","url":null,"abstract":"Objective: This study aimed to simplify the Jaw Functional Limitation Scale (JFLS) and evaluate its reliability and validity in assessing jaw function in patients with temporomandibular disorders (TMD) in primary care.Methods: TMD patients and non-TMD participants were assessed using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Demographic data and the 8-item JFLS questionnaire were collected to quantify jaw functional restriction. Confirmatory factor analysis tested the validity of JFLS-8 using chi-square, comparative fit index (CFI), root mean square error of approximation (RMSEA), and root mean square residual (RMR). The study selected key items from each domain to create a 4-item JFLS for further testing. Exploratory factor analysis, reliability, and validity tests were conducted.Results: Analysis included 671 valid questionnaires (502 TMD patients, 169 non-TMD participants). JFLS-8 exhibited satisfactory fit among TMD patients (RMSEA = 0.143, CFI = 0.881, RMR = 0.567). JFLS-4 retained items with high factor loadings: JFLS1 (0.935), JFLS2 (0.923), JFLS7 (0.766), and JFLS5 (0.713). The simplified JFLS-4 showed good reliability (Cronbach's alpha 0.714) and validity (Kaiser-Meyer-Olkin 0.558, Bartlett's test < 0.001) among TMD patients.Conclusion: A 4-item JFLS was developed and validated, demonstrating good reliability and validity in assessing mandibular function in TMD patients, exhibiting the potential to streamline evaluation processes in clinical practice.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tongue Coating Metabolites and Microbiome Associated With Intra-Oral Halitosis. 口腔内口臭与舌苔代谢物和微生物群有关。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15255

Xuan Xiao, Kaiyi Li, Zhaocheng Shi, Zhifeng Song

引用次数: 0

Comment on Systematic Review and Meta-Analysis on Betel-Quid Addictive Disorders and Oral Cancers. 槟榔液成瘾性疾病与口腔癌的系统评价与meta分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15258

Navneet Jain, Muhammed Shabil, Sanjit Sah

引用次数: 0

Validity and Utility of a Risk Prediction Model for Wound Infection After Lower Third Molar Surgery. 下第三磨牙手术后伤口感染风险预测模型的有效性和实用性。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15243

Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Keisuke Okamoto, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi

{"title":"Validity and Utility of a Risk Prediction Model for Wound Infection After Lower Third Molar Surgery.","authors":"Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Keisuke Okamoto, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi","doi":"10.1111/odi.15243","DOIUrl":"https://doi.org/10.1111/odi.15243","url":null,"abstract":"Objectives: To externally validate a clinical prediction model for surgical site infection (SSI) after lower third molar (L3M) surgery and evaluate its clinical usefulness.Methods: We conducted a retrospective cohort study of patients who underwent L3M surgery at Hokkaido University Hospital. The study was designed to evaluate the historical and methodological transportability. Clinical usefulness was evaluated using decision curve analysis on the data of the non-antibiotic-treated patients.Results: We obtained 2543 validation cohorts from April 2020 to March 2023, and 640 non-antibiotic cohorts from July 2010 to September 2023. The incidences of SSI after L3M surgery were 5.3% (135/2543) and 7.7% (49/640) in the validation and non-antibiotic cohorts, respectively. The discrimination ability of the prediction model was acceptable for the external validation cohort (c-statistic: 0.67; 95% CI: 0.62-0.71) and adequate for the non-antibiotic cohort (c-statistic: 0.72; 95% CI: 0.63-0.79). In both cohorts, the model showed excellent calibration between the observed and predicted probabilities. Decision curve analysis showed increased net benefit across a range of meaningful risk thresholds.Conclusion: A simple risk prediction model for SSI after L3M surgery demonstrated clinical transportability and usefulness. This model may help surgeons/clinicians determine the appropriateness of prophylactic antibiotics administration for patients in L3M surgery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable GC-IMS Is Promising to Detect Volatile Organic Compounds in Breath of Halitosis Patients. 便携式气相色谱- ims检测口臭患者呼气中挥发性有机物的前景广阔。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-01-10 DOI: 10.1111/odi.15254

Xiao Xian Qian

引用次数: 0