Radiographic Analysis of MRONJ in Osteoporotic and Oncologic Patients on Bisphosphonates or Denosumab.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-07-14 DOI:10.1111/odi.70030

Omar Ghanaiem, Gavriel Chaushu, Daya Masri

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引用次数: 0

Abstract

Introduction: Medication-Related Osteonecrosis of the Jaw (MRONJ) is a severe adverse effect of antiresorptive and antiangiogenic treatment, primarily in osteoporotic and oncologic patients. The disease is characterized by persistent jawbone necrosis that results in significant impairment of the quality of life of involved patients. The aim of this study is to compare the radiographic characteristics of MRONJ between osteoporotic and oncologic patients and assess the differences based on treatment type, particularly bisphosphonates and denosumab (RANK-L inhibitors).

Methods: A retrospective analysis of 152 MRONJ patients (41 osteoporotic, 111 oncologic) from Rabin-Bilinson Medical Center (2014-2024) examined radiographic features-lytic changes, sclerosis, periosteal reactions, sequestration, and periodontal ligament destruction-using panoramic radiography, CBCT, and MDCT.

Results: Sclerosis was more frequent in osteoporotic patients compared to oncologic patients (p < 0.05). No statistically significant differences were found in other radiographic features. Bisphosphonate-induced MRONJ was more frequently accompanied by sclerosis compared to denosumab-related cases in osteoporotic patients (p = 0.0318), while no significant differences were found in the oncologic group.

Conclusions: Most of the radiographic features of MRONJ were similar in osteoporotic and oncologic patients. However, sclerosis was more common in osteoporotic patients exposed to Bisphosphonates, which may be due to their prolonged exposure to antiresorptive drugs.

查看原文本刊更多论文

双膦酸盐或地诺单抗治疗的骨质疏松和肿瘤患者MRONJ的影像学分析。

药物相关性颌骨坏死（MRONJ）是抗吸收和抗血管生成治疗的严重不良反应，主要发生在骨质疏松症和肿瘤患者中。该疾病的特点是持续的颌骨坏死，导致患者的生活质量显著受损。本研究的目的是比较骨质疏松症和肿瘤患者MRONJ的影像学特征，并评估基于治疗类型的差异，特别是双膦酸盐和地诺单抗（RANK-L抑制剂）。方法：回顾性分析Rabin-Bilinson医学中心2014-2024年收治的152例MRONJ患者（骨质疏松41例，肿瘤111例）的影像学特征，包括溶解性改变、硬化、骨膜反应、隔离和牙周韧带破坏。结果：骨质疏松患者比肿瘤患者更易发生硬化症(p)。结论：骨质疏松患者与肿瘤患者MRONJ的大部分影像学特征相似。然而，硬化症在暴露于双膦酸盐的骨质疏松患者中更为常见，这可能是由于他们长期暴露于抗吸收药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.