Limosilactobacillus reuteri Improves Healing Following Fully Impacted Tooth Extractions: Randomized Clinical Trial.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-07-13 DOI:10.1111/odi.70026

Chiara Cinquini, Rossana Izzetti, Marco Nisi, Francesco Gulia, Berta Garcia Mira, Antonio Barone

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引用次数: 0

Abstract

Objectives: This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of L. reuteri administration on postsurgical wound healing, pain levels, and patient-reported outcomes (PROs) following extraction of fully impacted teeth.

Methods: Consecutive patients requiring surgical extractions were included and randomly allocated to either test (probiotic) or control group (placebo). Following oral hygiene procedures, patients began a daily probiotic/placebo intake 7 days before surgery until 14 days after surgery. Follow-up was performed at 3 (T3), 7 (T7), and 14 (T14) days postop. Wound healing, postoperative complications, pain, perceived functional impairment, and Oral Health Impact Profile-14 (OHIP-14) were registered.

Results: A total of 128 patients (67 in the test group and 61 in the control group) were analyzed. Wound healing significantly improved in the test group at T3 and T7. Trismus was significantly milder in the test group at T3 and T14. No differences in pain were noted. The test group experienced reduced chewing impairment and difficulty in oral hygiene procedures, exhibited significantly lower scores of OHIP-14 at T14, and required a reduced number of anti-inflammatory medications in the first 7 days.

Conclusions: Limosilactobacillus reuteri administration improved wound healing, reduced the severity of trismus, and was associated with improved PROs following impacted tooth extractions.

Trial registration: The study protocol was registered in a clinical trials database (Clinicaltrials.gov) with registration number NCT04903925.

查看原文本刊更多论文

罗伊氏乳酸杆菌促进全阻生拔牙后的愈合：随机临床试验。

目的：这项随机、双盲、安慰剂对照的临床试验评估罗伊氏乳杆菌对术后伤口愈合、疼痛水平和拔除全阻生牙后患者报告的结果（PROs）的影响。方法：纳入连续需要手术拔牙的患者，并随机分配到试验组（益生菌组）和对照组（安慰剂组）。遵循口腔卫生程序，患者在手术前7天开始每天服用益生菌/安慰剂，直到手术后14天。随访时间分别为术后3 （T3）、7 （T7）和14 （T14）天。记录伤口愈合、术后并发症、疼痛、感知功能损害和口腔健康影响概况-14 （OHIP-14）。结果：共分析128例患者，其中试验组67例，对照组61例。试验组在T3、T7时创面愈合明显改善。试验组在T3、T14时牙关明显减轻。疼痛程度无差异。试验组咀嚼损伤和口腔卫生操作困难减少，T14时OHIP-14得分明显降低，前7天需要的抗炎药物数量减少。结论：罗伊氏乳杆菌可改善伤口愈合，减轻牙关的严重程度，并可改善阻生拔牙后的PROs。试验注册：研究方案在临床试验数据库（Clinicaltrials.gov）中注册，注册号为NCT04903925。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.