Oral diseases最新文献

{"title":"Barriers to early diagnosis and management of oral cancer in Latin America and the Caribbean.","authors":"Josefina Martínez-Ramírez, Cristina Saldivia-Siracusa, Leonor-Victoria González-Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber-Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna-Molina, Gerardo Gilligan, Wilson Delgado-Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González-Arriagada, Mariana Villarroel-Dorrego, Bernardo Venegas Rojas, Karen Patricia Domínguez Gallagher, Elena María José Román Tager, Saray Aranda-Romo, Gilda Lucía García-Heredia, Efrain Cima Garcia, Ileana Hurtado, Claudette Arambú Turcios, Leira Patricia Solis Espinal, Rúben Alexander Martínez González, Ana Carolina Prado Ribeiro, Rejane Faria Ribeiro-Rotta, Luiz Paulo Kowalski, Maria Paula Curado, Tatiana Natasha Toporcov, Thomas Peter Sollecito, Andre Lopes Carvalho, Marcio Ajudarte Lopes, Saman Warnakulasuriya, Alan Roger Santos-Silva","doi":"10.1111/odi.14903","DOIUrl":"10.1111/odi.14903","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore perceived barriers to early diagnosis and management of oral cancer, as well as potential pathways for improvement in Latin America and the Caribbean (LAC).</p><p><strong>Methods: </strong>This cross-sectional study used a self-administered online questionnaire created via the Research Electronic Data Capture platform. The survey was distributed to health professionals trained in Oral Medicine, Oral Pathology, Oral and Maxillofacial Surgery, and Dentists with clinical and academic expertise in oral potentially malignant disorder (OPMD) and oral cancer. Data obtained were systematically organized and analyzed descriptively using Microsoft Excel.</p><p><strong>Results: </strong>Twenty-three professionals from 21 LAC countries participated. Major barriers included the limited implementation of OPMD and oral cancer control plans (17.4%), low compulsory reporting for OPMD (8.7%) and oral cancer (34.8%), unclear referral pathways for OPMD (34.8%) and oral cancer (43.5%), and a shortage of trained professionals (8.7%). Participants endorsed the utility of online education (100%) and telemedicine (91.3%).</p><p><strong>Conclusion: </strong>The survey highlights major perceived barriers to early diagnosis and management of OPMD and oral cancer in LAC, as well as potential avenues for improvement.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4174-4184"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The minimally important difference for the Xerostomia Inventory among Sjögren's disease patients.","authors":"Zainab Assy, William Murray Thomson, Henk S Brand, Seunghee Cha, Merve M Susam, Gary A Weisman, Arjan Vissink, Floris J Bikker, Derk Hendrik Jan Jager","doi":"10.1111/odi.14841","DOIUrl":"10.1111/odi.14841","url":null,"abstract":"<p><strong>Objective: </strong>Until now, the clinically relevant improvement for the Xerostomia Inventory (XI) has not been defined. Therefore, our aim was to determine the Minimally Important Difference (MID) of the XI for improvement in dry-mouth symptoms in SjD patients.</p><p><strong>Method: </strong>The study recruited 34 SjD patients who underwent sialendoscopy of major salivary glands and 15 SjD patients in a nonintervention control group. XI scores were assessed at several time points. The MID was determined from the mean difference in XI scores between the groups with and without improvement.</p><p><strong>Results: </strong>In the control group, no significant XI score changes were seen. In the sialendoscopy group, a clinically relevant XI score change of four scale points was identified after 1 week. For a prolonged duration (≥16 weeks), a minimum reduction of seven scale points in the XI score was required to indicate clinically relevant improvement.</p><p><strong>Conclusion: </strong>In SjD patients, a minimum change of four points in the XI score indicates a clinically relevant improvement for evaluating short-term effects. For prolonged effects, a clinically relevant improvement requires a MID of seven points. The determination of the MID in XI could assist in future studies that evaluate changes in xerostomia.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4356-4363"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adaptation of the Thai Xerostomia Inventory and Summated Xerostomia Inventory.","authors":"Chotima Lapnimitanun, Paswach Wiriyakijja, Oranart Matangkasombut, Orapin Komin","doi":"10.1111/odi.14891","DOIUrl":"10.1111/odi.14891","url":null,"abstract":"<p><strong>Objective: </strong>To cross-culturally adapt and validate the Thai version of the Xerostomia Inventory (XI) and Summated Xerostomia Inventory (SXI) for subjective evaluation of oral dryness in Thai middle-aged and older adults.</p><p><strong>Methods: </strong>The original English versions of the XI and SXI were cross-culturally translated into Thai. Content validity was examined by the expert panel and 30 pilot subjects. The XI/SXI-Thai were then administered to 200 Thai adults (aged 50 years or older) for further assessment of psychometric properties. The standard question, the Bother Index, and the Xerostomia Questionnaire were used as comparator instruments for the evaluation of criterion and construct validity, respectively. Internal consistency reliability was assessed using Cronbach's alpha.</p><p><strong>Results: </strong>The final XI/SXI-Thai were found to have good content validity. Both scales were able to distinguish between xerostomia and non-xerostomia groups. We observed moderate to strong correlation between the XI/SXI-Thai and other comparator instruments, reflecting good criterion and construct validity. Cronbach's alpha values were 0.875 and 0.847 for the XI-Thai and SXI-Thai, respectively.</p><p><strong>Conclusions: </strong>The XI-Thai and SXI-Thai were found to be valid, reliable, and easily administrable instruments for xerostomia assessment in Thai middle-aged and older individuals in both clinical and research settings.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4331-4340"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral submucosal fibrosis: An updated molecular mechanism on pathogenesis and treatment modalities.","authors":"Vadivel Jayanth Kumar, Devaraj Ezhilarasan, Deepak Nallasamy Veeraiyan","doi":"10.1111/odi.14901","DOIUrl":"10.1111/odi.14901","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4798-4799"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoledronic acid enhances tumor growth and metastatic spread in a mouse model of jaw osteosarcoma.","authors":"Than-Thuy Nham, Romain Guiho, Régis Brion, Jérôme Amiaud, Bénédicte Brounais Le Royer, Anne Gomez-Brouchet, Françoise Rédini, Hélios Bertin","doi":"10.1111/odi.14897","DOIUrl":"10.1111/odi.14897","url":null,"abstract":"<p><strong>Objectives: </strong>Investigation of the therapeutic effect of zoledronic acid (ZA) in a preclinical model of jaw osteosarcoma (JO).</p><p><strong>Materials and methods: </strong>The effect of 100 μg/kg ZA administered twice a week was assessed in a xenogenic mouse model of JO. The clinical (tumor growth, development of lung metastasis), radiological (bone microarchitecture by micro-CT analysis), and molecular and immunohistochemical (TRAP, RANK/RANKL, VEGF, and CD146) parameters were investigated.</p><p><strong>Results: </strong>Animals receiving ZA exhibited an increased tumor volume compared with nontreated animals (71.3 ± 14.3 mm³ vs. 51.9 ± 19.9 mm³ at D14, respectively; p = 0.06) as well as increased numbers of lung metastases (mean 4.88 ± 4.45 vs. 0.50 ± 1.07 metastases, respectively; p = 0.02). ZA protected mandibular bone against tumor osteolysis (mean bone volume of 12.81 ± 0.53 mm³ in the ZA group vs. 11.55 ± 1.18 mm³ in the control group; p = 0.01). ZA induced a nonsignificant decrease in mRNA expression of the osteoclastic marker TRAP and an increase in RANK/RANKL bone remodeling markers.</p><p><strong>Conclusion: </strong>The use of bisphosphonates in the therapeutic strategy for JO should be further explored, as should the role of bone resorption in the pathophysiology of the disease.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4209-4219"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-life experience of long-term use of pilocarpine in irradiated head and neck cancer patients.","authors":"Rungarun Kittichet, Imjai Chitapanarux, Kittikun Kittidachanan, Patumrat Sripan","doi":"10.1111/odi.14905","DOIUrl":"10.1111/odi.14905","url":null,"abstract":"<p><strong>Aims: </strong>To assess long-term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation-induced xerostomia (RIX).</p><p><strong>Methods: </strong>Retrospective observational study was conducted. Eligibility criteria included irradiated HNC patients who received pilocarpine at least 12 weeks either for prevention (group A) or for treatment (group B) of RIX. We collected the documented Late Effect Normal Tissue Task Force-Subjective, Objective, Management, Analytics subjective/objective grades of RIX before (only group B) and the latest visit for pilocarpine prescription, dosage, side effects, duration of treatment, and the cause of discontinuation.</p><p><strong>Results: </strong>Between December 2007 and June 2022, 182 patients were enrolled including 95 patients (52%) in group A and 87 patients (48%) in group B. Group A patients reported grades 1, 2, 3, and 4 objective RIX in 0%, 7%, 93%, and 0%. Grade 1, 2, and 3 subjective RIX were 57%, 28%, and 15%. All patients in group B had grade 3 both objective/subjective RIX. The overall improvement of objective/subjective RIX was found in 40%/83%. Discontinuation was found in 51% of patients due to tolerable symptoms or deterioration of the patient's status.</p><p><strong>Conclusions: </strong>Based on this retrospective analysis, long-term use of pilocarpine in irradiated HNC appears feasible for both prevention and treatment of RIX.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4312-4319"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short and long effects of the COVID-19 context on oral health-related quality of life of adolescents.","authors":"Marina Blanco Pohl, Thais Gioda Noronha-Ramos, Jessica Klöckner Knorst, Marcia Farias Pereira Lito, Gabriela de Araujo, Bruno Emmanuelli, Thiago Machado Ardenghi, Fernanda Tomazoni","doi":"10.1111/odi.14885","DOIUrl":"10.1111/odi.14885","url":null,"abstract":"<p><strong>Aim: </strong>To assess the immediate and late effects of the COVID-19 pandemic on the oral health-related quality of life (OHRQoL) of adolescents.</p><p><strong>Design: </strong>This is a longitudinal study performed with adolescents (11-15 years old) from Southern Brazil who were evaluated before the COVID-19 outbreak, and 3 (T2) and 15 (T3) months after the beginning of the pandemic. OHRQoL was assessed using the CPQ11-14. Sociodemographic and clinical variables were also collected. Changes in OHRQoL before, 3 and 15 months after the start of the pandemic were analyzed through multilevel Poisson regression models for repeated measures.</p><p><strong>Results: </strong>A total of 290 adolescents were evaluated at T1, 207 were re-evaluated at T2, and 204 at T3. Overall CPQ11-14 scores over follow-ups were 11.0 (SD 8.0) at T1, 8.3 (SD 7.8) and 12.8 (SD 8.8) at T3. Compared to T1, adolescents presented 29% lower overall CPQ11-14 scores (IRR 0.71 95% CI 0.66-0.75) at T2, and 11% higher scores at T3 (IRR 1.11 95% CI 1.05-1 0.17), especially for the emotional and social well-being domains.</p><p><strong>Conclusion: </strong>COVID-19 pandemic impacted the adolescents' OHRQoL differently over time, indicating a reduction in impacts immediately after the beginning and worsening over long term exposure to this scenario.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4683-4690"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and oral health: Assessing the impacts and developing strategies for adaptation.","authors":"Delfin Lovelina Francis, Saravanan Sampoornam Pape Reddy, Anitha Logaranjani, Sukhbir Singh Chopra","doi":"10.1111/odi.14922","DOIUrl":"10.1111/odi.14922","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4792-4793"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophils are involved in early bone formation during midpalatal expansion.","authors":"Ting Jiang, Xin-Yue Tang, Han Su, Jia-Yi Chen, Yu-Qi Qin, Yu-Chen Qin, Ning-Juan Ouyang, Guo-Hua Tang","doi":"10.1111/odi.14849","DOIUrl":"10.1111/odi.14849","url":null,"abstract":"<p><strong>Objective: </strong>Midpalatal expansion (MPE) is routinely employed to treat transverse maxillary arch deficiency. Neutrophils are indispensable for recruiting bone marrow stromal cells (BMSCs) at the initial stage of bone regeneration. This study aimed to explore whether neutrophils participate in MPE and how they function during bone formation under mechanical stretching.</p><p><strong>Materials and methods: </strong>The presence and phenotype of neutrophils in the midpalatal suture during expansion were detected by flow cytometry and immunofluorescence staining. The possible mechanism of neutrophil recruitment and polarization was explored in vitro by exposing vascular endothelial cells (VECs) to cyclic tensile strain.</p><p><strong>Results: </strong>The number of neutrophils in the distracted suture peaked on Day 3, and N2-type neutrophils significantly increased on Day 5 after force application. The depletion of circulatory neutrophils reduced bone volume by 43.6% after 7-day expansion. The stretched VECs recruited neutrophils via a CXCR2 mechanism in vitro, which then promoted BMSC osteogenic differentiation through the VEGFA/VEGFR2 axis. Consistently, these neutrophils showed higher expression of canonical N2 phenotype genes, including CD206 and Arg1.</p><p><strong>Conclusions: </strong>These results suggested that neutrophils participated in early bone formation during MPE. Based on these findings, we propose that stretched VECs recruited and polarized neutrophils, which, in turn, induced BMSC osteogenic differentiation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4483-4494"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138885698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Live dietary microbes and reduced prevalence of periodontitis: A cross-sectional study.","authors":"Jie Lin, Hui Yang, Zhengshen Lin, Lingqiao Xu","doi":"10.1111/odi.14869","DOIUrl":"10.1111/odi.14869","url":null,"abstract":"<p><strong>Objective: </strong>Investigate the link between live dietary microbe consumption and the prevalence of periodontitis.</p><p><strong>Methods and materials: </strong>National health and nutrition examination survey (2009-2014) data was used to assess the association among adults. Live dietary microbe intake was categorized as low or medium to high. Regression models were employed to assess this association, adjusting for demographic variables and other covariates. Examined dose-response relationship and conducted subgroup analyses by ethnicity, age and gender. Multiplicative interactions were evaluated using likelihood ratio tests.</p><p><strong>Results: </strong>The analysis included 8574 participants. After adjusting for various factors including age, gender, ethnicity, dietary habits, dietary inflammatory index, alcohol consumption, smoking status, hypertension, diabetes mellitus and oral health behaviors, individuals with daily intake of medium to high levels of live dietary microbes showed a significantly reduced risk of periodontitis compared to those who did not consume such microbes with a dose-response trend (p for trend <0.0001, p < 0.01). Significant differences in the impact of live microbe intake on periodontitis were also observed across different age groups in all Models (p for interaction ≤0.05).</p><p><strong>Conclusion: </strong>Medium to high live dietary microbe consumption independently correlates with lower periodontitis risk, irrespective of traditional risk factors and demographics.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4639-4649"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}