Oral diseases最新文献_第10页

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 DOI: 10.1111/odi.70057

Dulyapong Rungraungrayabkul, Nis Okuma

引用次数: 0

Binary- and Three-Tiered Oral Epithelial Dysplasia Grading System and Malignant Transformation. 二、三级口腔上皮发育不良分级系统与恶性转化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI: 10.1111/odi.15334

Riikka Ellonen, Jetta Kelppe, Jaana Hagström, Auli Suominen, Jaana Willberg, Jaana Rautava, Hanna K Laine

{"title":"Binary- and Three-Tiered Oral Epithelial Dysplasia Grading System and Malignant Transformation.","authors":"Riikka Ellonen, Jetta Kelppe, Jaana Hagström, Auli Suominen, Jaana Willberg, Jaana Rautava, Hanna K Laine","doi":"10.1111/odi.15334","DOIUrl":"10.1111/odi.15334","url":null,"abstract":"Objectives: Oral epithelial dysplasia (OED) can be graded histopathologically by using a binary- or three-tiered grading system. This study aimed to analyze and compare the prognostic value of the two systems in a large single-institute material.Materials and methods: The study was a retrospective histopathological re-evaluation analysis of 612 OEDs over 29 years at the Institute of Dentistry, University of Turku, Turku, Finland. OED patients who later developed squamous cell carcinoma (OSCC) were identified from the Finnish Cancer Registry database.Results: Altogether, the mean age of 612 OEDs patients was 59.9 years. The male:female ratio was 0.67. According to the original three-tiered diagnosis, 67.7% of the samples were mild dysplasia, 28.7% moderate dysplasia, and 3.6% severe dysplasia cases. With binary-tiered diagnosis, low-grade dysplasia 84.1% was more common than high-grade dysplasia 15.9%. The malignant transformation rate was 7.8%. Regarding oral SCC development, no difference was found between the grading systems in predicting the malignant progression (p = 0.060).Conclusions: Both binary- and three-tiered grading systems of dysplasia classification had similar predictive value for malignant transformation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2419-2426"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Differentiation of DPSCs Infected With Different Periodontal Pathogens. 不同牙周病原菌感染DPSCs的细胞分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-30 DOI: 10.1111/odi.70045

Tiansong Xu, Xiaofen Chai, Wen Zhang, Xueying Li, Yifei Zhang, Qian Zhang, Lin Yue, Xiaoying Zou, Feng Chen

{"title":"Cell Differentiation of DPSCs Infected With Different Periodontal Pathogens.","authors":"Tiansong Xu, Xiaofen Chai, Wen Zhang, Xueying Li, Yifei Zhang, Qian Zhang, Lin Yue, Xiaoying Zou, Feng Chen","doi":"10.1111/odi.70045","DOIUrl":"https://doi.org/10.1111/odi.70045","url":null,"abstract":"Aim: The aim of the present study was to investigate the effects of Capnocytophaga periodontitidis (C. periodontitidis) and Porphyromonas gingivalis (P. gingivalis) on dental pulp stem cells (DPSCs) subclusters.Materials and methods: DPSCs were collected from healthy donors and were infected with C. periodontitidis or P. gingivalis. High-throughput single-cell RNA sequencing of infected DPSCs was performed to analyze gene expression changes, focusing on differentiation, hypoxia, and cell cycle-related pathways.Results: Based on our single-cell resolution analysis, four major DPSC clusters were identified: classical-like, fibroblast-like, smooth muscle-like, and perivascular-like. C. periodontitidis infection induced differentiation into smooth muscle-like cells, while P. gingivalis promoted fibroblast (mineralized) lineages. P. gingivalis had a more significant effect on DPSCs differentiation. A specific subcluster responded uniquely to C. periodontitidis, with gene expression linked to B cell activation, muscle proliferation, and ROS pathways.Conclusion: DPSCs showed the homogeneity and heterogeneity when infected by these two pathogens. DPSCs differentiated into smooth muscle-related cells and mineralization-related cells when infected by C. periodontitidis and P. gingivalis, respectively. Our results will facilitate understanding and therapeutic strategies of primary periodontal disease with secondary endodontic involvement.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ototoxicity in Cancer Therapies. 癌症治疗中的耳毒性。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-30 DOI: 10.1111/odi.70046

Sady Selaimen da Costa, Nathaniel S Treister, Caio Eddie de Melo Alves

引用次数: 0

Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study. 子宫内膜异位症相关牙周病：一项大型队列研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-26 DOI: 10.1111/odi.70044

Maria Teresa Agneta, Giuseppe D'Albis, Letizia Lorusso, Nicola Bartolomeo, Antonia Abbinante, Anna Antonacci, Pietro Signorile, Francesco D'Aiuto, Elisa Mazza, Massimo Corsalini, Saverio Capodiferro

{"title":"Endometriosis-Associated Periodontal Disease: A Large Cohort Perspective Study.","authors":"Maria Teresa Agneta, Giuseppe D'Albis, Letizia Lorusso, Nicola Bartolomeo, Antonia Abbinante, Anna Antonacci, Pietro Signorile, Francesco D'Aiuto, Elisa Mazza, Massimo Corsalini, Saverio Capodiferro","doi":"10.1111/odi.70044","DOIUrl":"https://doi.org/10.1111/odi.70044","url":null,"abstract":"Objective: Endometriosis is a chronic estrogen-dependent gynecological disease affecting millions of women worldwide. Besides its well-established impact on reproductive health, emerging evidence suggests a potential association between endometriosis and periodontal disease. The present study discusses the interplay between the two diseases, exploring shared immunopathological mechanisms, including chronic inflammation, hormonal imbalance, and immune system modulation.Materials and methods: A 45-question standardized questionnaire was answered by 4072 women clinically diagnosed with endometriosis to identify self-reported periodontal status, oral hygiene habits, and systemic symptoms.Results: Findings report that more severe stages of endometriosis are related to increased awareness of periodontal disease, greater gingival bleeding, xerostomia, and mucosal alterations. Moreover, greater diagnostic latency aggravates both systemic and oral disorders, supporting the necessity of early treatment. These findings highlight the need for a single, multidisciplinary standard of patient care involving gynecologists, dentists, dental hygienists, and other healthcare providers.Conclusion: By connecting gynecological and dental care, this study aims to promote awareness, facilitate early diagnosis, and improve quality of life for women suffering from endometriosis. Future research must explore mechanisms linking the conditions and assess therapeutic approaches to alleviate oral health issues in these individuals.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA FENDRR Inhibits Mitochondrial Apoptosis via TET2-Mediated DNA Demethylation of MFN1 in NSCPO. LncRNA FENDRR通过tet2介导的MFN1 DNA去甲基化抑制NSCPO中线粒体凋亡。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-26 DOI: 10.1111/odi.70035

Caihong Wu, Haojie Liu, Zerui Shan, Yu Xia, Panpan Zhao, Zhongyin Zhang, Gu Yueguang, Junqing Ma

{"title":"LncRNA FENDRR Inhibits Mitochondrial Apoptosis via TET2-Mediated DNA Demethylation of MFN1 in NSCPO.","authors":"Caihong Wu, Haojie Liu, Zerui Shan, Yu Xia, Panpan Zhao, Zhongyin Zhang, Gu Yueguang, Junqing Ma","doi":"10.1111/odi.70035","DOIUrl":"https://doi.org/10.1111/odi.70035","url":null,"abstract":"Background: Non-syndromic cleft palate only (NSCPO) and non-syndromic cleft lip with or without cleft palate (NSCL/P) are distinct malformations with different or partially overlapping etiologies. While NSCL/P has been extensively studied, NSCPO remains relatively understudied. Emerging evidence suggests that long noncoding RNAs (lncRNAs) contribute to craniofacial development, potentially by regulating apoptosis.Methods: This study investigated the role of FENDRR, a lncRNA previously found to be downregulated in NSCL/P, in NSCPO pathogenesis. FENDRR expression in NSCPO tissues was analyzed via RT-qPCR and fluorescence in situ hybridization. Apoptosis in human embryonic palatal mesenchymal (HEPM) cells was assessed using Western blotting, flow cytometry, and TUNEL assays. Bioinformatics, methylation-specific PCR, dual-luciferase reporter assays, and RNA immunoprecipitation were employed to examine FENDRR's interaction with MFN1.Results: FENDRR was significantly reduced in NSCPO tissues. FENDRR knockdown disrupted mitochondrial dynamics and activated mitochondrial apoptosis in HEPM cells. Mechanistically, FENDRR formed an RNA-DNA triplex with the MFN1 promoter, recruiting TET2 to promote MFN1 transcription via promoter demethylation.Conclusions: FENDRR enhances MFN1 expression, maintains mitochondrial fusion, and suppresses apoptosis in HEPM cells. This study provides novel insights into the regulatory role of lncRNAs in NSCPO pathogenesis and identifies FENDRR as a potential therapeutic target.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Lymphocyte Infiltration Shapes Corticosteroid Efficacy in Oral Lichen Planus. 不同淋巴细胞浸润影响皮质类固醇治疗口腔扁平苔藓的疗效。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70038

Yiwen Deng, Yufeng Wang, Junjun Chen, Guanhuan Du, Hui Yao, Lei Pan, Ting Gu, Sven Eric Niklander, Zhen Tian, Guoyao Tang

{"title":"Differential Lymphocyte Infiltration Shapes Corticosteroid Efficacy in Oral Lichen Planus.","authors":"Yiwen Deng, Yufeng Wang, Junjun Chen, Guanhuan Du, Hui Yao, Lei Pan, Ting Gu, Sven Eric Niklander, Zhen Tian, Guoyao Tang","doi":"10.1111/odi.70038","DOIUrl":"https://doi.org/10.1111/odi.70038","url":null,"abstract":"Background: Oral lichen planus (OLP) is a chronic, immune-mediated disorder affecting 2%-4% of the population. Corticosteroids are commonly used for treatment, but responses vary, likely due to differences in lymphocyte profiles. This study evaluated the impact of CD20+ B cells and CD38+ plasma cells on corticosteroid efficacy in OLP patients.Patients and methods: This retrospective study included 101 patients with symptomatic, diffuse, and severe OLP. Immunohistochemical staining identified CD3+ T cells, CD20+ B cells, and CD38+ plasma cells in tissue lesions. All patients received prednisone, and outcomes were assessed using Reticulation/Erosion/Ulceration (REU) and Visual Analog Scale (VAS) scores. Statistical analyses compared treatment responses based on lymphocyte profiles.Results: All patients showed CD3-positive T cell infiltration. Patients in the CD20- group showed significantly greater reductions in REU and VAS scores than the CD20+ group, indicating that B cell infiltration may reduce corticosteroid efficacy. Conversely, CD38+ patients exhibited greater score reductions than CD38- patients, suggesting that plasma cells may enhance responsiveness to treatment. The CD38+/CD20- group exhibited the most favorable response; the CD38-/CD20+ group had the least.Conclusions: Infiltration by B cells and plasma cells influences corticosteroid response in OLP. B cells are associated with reduced efficacy, while plasma cells correlate with improved treatment outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hard Nodule on the Posterior Portion of the Tongue in a Young Patient. 一个年轻病人舌后部的硬结节。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70039

Jing Xu, Ying Wan, Jiangning Luo, Hanwen Chu

引用次数: 0

Speech and Swallowing Disorders in Adolescent and Young Adults With Oral Cavity Cancer. 青少年和青年口腔癌患者的语言和吞咽障碍

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-25 DOI: 10.1111/odi.70041

Wei Deng, Guiyi Zhao, Yudong Xiao, Kaixin Guo, Sien Zhang, Guiqing Liao, Le Yang, Yujie Liang

{"title":"Speech and Swallowing Disorders in Adolescent and Young Adults With Oral Cavity Cancer.","authors":"Wei Deng, Guiyi Zhao, Yudong Xiao, Kaixin Guo, Sien Zhang, Guiqing Liao, Le Yang, Yujie Liang","doi":"10.1111/odi.70041","DOIUrl":"https://doi.org/10.1111/odi.70041","url":null,"abstract":"Objective: To evaluate the speech and swallowing function and recovery status in adolescent and young adult (AYAs) patients with oral cavity cancer (OCC).Methods: A cohort study was conducted in AYAs patients with OCC from August 2019 to April 2021. The swallowing and speech functions were evaluated by M.D. Anderson dysphagia inventory (MDADI), 10-item eating assessment tool (EAT-10) and speech handicap index (SHI) at pretreatment and postoperative stages. Multiple linear regression and linear mixed models were employed.Results: A total of 661 patients were enrolled, including 143 AYAs and 518 individuals aged ≥ 40. The preoperative total scores of MDADI, EAT-10, and SHI were worse in AYAs patients. AYAs patients with advanced T stage (T3-T4) before surgery exhibited worse scores for MDADI, EAT-10, and SHI. All patients presented the poorest outcomes within the initial 3 months postoperatively. However, a more rapid recovery trend of swallowing and speech function was demonstrated in the AYAs. Adjuvant radiotherapy/chemotherapy, advanced T stage (T3-T4), tracheostomy, or flap reconstruction were key risk factors of impairing speech and swallowing functions in AYAs patients.Conclusions: AYAs experience worse speech and swallowing function in the pretreatment stage and generally exhibit a higher potential for recovery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD. 从发育不良到癌：真皮因子、基质酶和胰蛋白酶在OPMD中的表达模式。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-24 DOI: 10.1111/odi.70043

Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Carol Kobori da Fonseca, Pedro Franco Ferreira, Leandro Dorigan de Macedo, Graziela Cavalcanti, Luiz Carlos Conti de Freitas, Ana Carolina Fragoso Motta, Alan Grupioni Lourenço, Katiuchia Uzzun Sales

{"title":"From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD.","authors":"Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Carol Kobori da Fonseca, Pedro Franco Ferreira, Leandro Dorigan de Macedo, Graziela Cavalcanti, Luiz Carlos Conti de Freitas, Ana Carolina Fragoso Motta, Alan Grupioni Lourenço, Katiuchia Uzzun Sales","doi":"10.1111/odi.70043","DOIUrl":"https://doi.org/10.1111/odi.70043","url":null,"abstract":"Background: The malignant transformation of oral potentially malignant disorders (OPMDs) lacks reliable molecular markers. Dermokine and matriptase are involved in epithelial differentiation and inflammation, while tryptase is associated with the tumor microenvironment, which may contribute to carcinogenesis. This study investigated these molecules as potential biomarkers for predicting the malignant progression of OPMDs.Methods: This was a cross-sectional comparative study. Paired normal oral mucosa (NM) and OPMD tissues (n = 21) were assessed, while oral and oropharyngeal squamous cell carcinoma (OOSCC) samples (n = 64) were evaluated using tissue microarrays. Proteomic analysis of five OPMD cases identified dermokine, tryptase, and matriptase as potential biomarkers, further examined through clinical, histopathological, and immunohistochemical analyses across NM, OPMD, and OOSCC tissues.Results: Females comprised 52% of the OPMD group, whereas males accounted for 87.5% of OOSCC cases. Dermokine, tryptase, and matriptase showed higher expression in OPMD and OOSCC than NM. Dermokine was predominantly observed in OPMD, well-differentiated OOSCC, and NM from patients who progressed to malignancy (p = 0.019). Matriptase expression shifted from membranous in NM to diffuse in OPMD and OOSCC, similarly to tryptase.Conclusion: Dermokine may represent an early marker of transformation, while altered matriptase patterns could help differentiate dysplasia from carcinoma.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0