Oral diseases最新文献_第10页

Clinical Relevance of Lymphovascular and Perineural Invasion in Oral Squamous Cell Carcinoma: Emphasis on Pathological N1 Cases. 口腔鳞状细胞癌淋巴血管及周围神经浸润的临床意义：以病理N1病例为重点。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70472

Juan Carlos de Vicente, Álvaro Fernández Del Valle, Tania Rodríguez Santamarta, Ignacio Peña, Lucas Villalaín Álvarez, Sergi Herrera I Nogués, Ana Martínez-Carrillo, Miriam Rubiera-Valdés, Paloma Lequerica-Fernández

{"title":"Clinical Relevance of Lymphovascular and Perineural Invasion in Oral Squamous Cell Carcinoma: Emphasis on Pathological N1 Cases.","authors":"Juan Carlos de Vicente, Álvaro Fernández Del Valle, Tania Rodríguez Santamarta, Ignacio Peña, Lucas Villalaín Álvarez, Sergi Herrera I Nogués, Ana Martínez-Carrillo, Miriam Rubiera-Valdés, Paloma Lequerica-Fernández","doi":"10.1111/odi.70472","DOIUrl":"https://doi.org/10.1111/odi.70472","url":null,"abstract":"Objective: This study aimed to investigate the clinical relevance of lymphovascular invasion (LVI) and perineural invasion (PNI) in oral squamous cell carcinoma (OSCC).Methods: We conducted a retrospective study of 181 OSCC patients, analyzing clinical outcomes in terms of disease-specific survival (DSS) and disease-free survival (DFS).Results: In multivariate analysis, T classification, LVI, and PNI were independent predictors of nodal metastasis, while nodal metastasis and extranodal extension were independent predictors of DSS, and T classification and nodal status were independent predictors of DFS. In N1 cases, LVI was significantly associated with poorer DSS and DFS. Survival was also significantly worse in double-positive patients (LVI and PNI) compared with double-negative or single-positive cases.Conclusion: The presence of LVI and/or PNI is an independent risk factor for node metastasis, even when accounting for other factors such as DOI. N1 tumors with LVI show significantly poorer DSS and DFS, regardless of extranodal extension.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Diagnostic Challenge: Unilateral Gingival Enlargement With Altered Tooth Eruption in a Paediatric Patient. 诊断的挑战：单侧牙龈扩大与改变牙齿萌出的儿科患者。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70430

Luca Cricenti, Rossella Ninivaggi, Federico Liguori, Nicola Scotti, Allegra Comba, Patrizia Defabianis, Federica Romano

引用次数: 0

Tegafur-Uracil (UFUR) as Maintenance Therapy in Resectable and Unresectable Head and Neck Squamous Cell Carcinoma: A Narrative Review. 替加福-尿嘧啶（UFUR）作为可切除和不可切除的头颈部鳞状细胞癌的维持治疗：叙述回顾。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70471

Hui-Ching Wang, Pen-Yuan Chu

{"title":"Tegafur-Uracil (UFUR) as Maintenance Therapy in Resectable and Unresectable Head and Neck Squamous Cell Carcinoma: A Narrative Review.","authors":"Hui-Ching Wang, Pen-Yuan Chu","doi":"10.1111/odi.70471","DOIUrl":"https://doi.org/10.1111/odi.70471","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) remains associated with high rates of locoregional recurrence and distant metastasis despite definitive treatment. Metronomic tegafur-uracil (UFUR), an oral fluoropyrimidine comprising tegafur and uracil, has emerged as a potential maintenance strategy because of its cytotoxic, immunomodulatory, and anti-angiogenic mechanisms mediated by 5-fluorouracil (5-FU) and gamma-hydroxybutyric acid (GHB). This narrative review summarizes current evidence on UFUR maintenance in both resectable and unresectable HNSCC. Most available evidence is derived from retrospective and observational studies using maintenance durations ranging from approximately 6 months to 2 years. A recent meta-analysis of six observational studies (n = 1373) reported pooled hazard ratios of 0.68 for progression-free survival and 0.54 for overall survival; however, trial sequential analysis supported sufficient evidence only for progression-free survival, whereas the overall-survival evidence remained inconclusive. Published cohorts suggest potential benefits in selected high-risk patients and a generally manageable toxicity profile, but their findings remain susceptible to selection bias, residual confounding, and immortal-time bias. Prospective randomized trials are needed to confirm clinical benefit and define optimal treatment duration, patient selection, and potential integration with contemporary immunotherapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the Arabic Xerostomia Questionnaire (XQ-A): A National Study Among Head and Neck Cancers. 阿拉伯口干问卷（XQ-A）的验证：一项头颈部癌症的全国性研究。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70469

Mohammad Minwer Alnaeem, Alaa Abuattallah, Sameera Khaled Darwish

{"title":"Validation of the Arabic Xerostomia Questionnaire (XQ-A): A National Study Among Head and Neck Cancers.","authors":"Mohammad Minwer Alnaeem, Alaa Abuattallah, Sameera Khaled Darwish","doi":"10.1111/odi.70469","DOIUrl":"https://doi.org/10.1111/odi.70469","url":null,"abstract":"Background: Xerostomia is a common acute and late adverse effect of radiotherapy in patients with head and neck cancer (HNC).Aims/objectives: This study aimed to validate the Arabic version of the eight-item self-reported Xerostomia Questionnaire (XQ) and to evaluate its psychometric properties among patients undergoing radiotherapy for HNC.Material and methods: A cross-sectional study was conducted in the Radiotherapy Unit. The XQ was translated into Arabic following established international guidelines. A total of 187 patients completed the questionnaire. Construct validity was assessed using confirmatory factor analysis. Internal consistency and test-retest reliability were evaluated using Cronbach's α coefficient and McDonald's omega. Convergent-related validity was examined.Results: The results confirmed a unidimensional structure of XQ with CFA (χ2(28) = 52.1, p < 0.001; CFI = 0.996; TLI = 0.984; RMSEA = 0.068; SRMR = 0.013). All items loaded significantly onto a single factor. The scale demonstrated excellent internal consistency with Cronbach's α = 0.952 (range 0.93-0.96) and McDonald's ω = 0.948. Test-retest reliability was excellent (ICC = 0.93). The correlations with the SDQ and MNA-SF supported convergent-related validity.Conclusions and significance: The Arabic XQ shows excellent psychometric performance and is suitable for assessing xerostomia severity in Arabic-speaking patients with HNC undergoing radiotherapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple White Lesions in the Oral Mucosa. 口腔黏膜多发白色病变。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70454

Irene Lafuente-Ibáñez de Mendoza, Alessandra Ortíz-Alves, José Manuel Sioli-Durán, José Manuel Aguirre-Urizar

引用次数: 0

p21 Inhibition Rescues Radiation-Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb-Smad2/3-Runx2 Axis. p21抑制通过Rb-Smad2/3-Runx2轴恢复辐射诱导的颌骨骨坏死成骨功能障碍并促进骨再生

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70408

Jiaying Shi, Shuxian Lin, Jiayu Yan, Wanyi Tang, Xiaohua Wu, Shuwen Ding, Siyi Chen, Ruowen Zhao, Junhua Wu

{"title":"p21 Inhibition Rescues Radiation-Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb-Smad2/3-Runx2 Axis.","authors":"Jiaying Shi, Shuxian Lin, Jiayu Yan, Wanyi Tang, Xiaohua Wu, Shuwen Ding, Siyi Chen, Ruowen Zhao, Junhua Wu","doi":"10.1111/odi.70408","DOIUrl":"https://doi.org/10.1111/odi.70408","url":null,"abstract":"Background: Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown.Methods: An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was analyzed and validated in vivo. Irradiated jaw bone marrow mesenchymal stem cells (JBMMSCs) were characterized. p21 was inhibited using UC2288 and siRNA. A UC2288-loaded AlgMA hydrogel was developed for local delivery.Results: Bone healing was compromised in ORNJ. Radiation induced p21 upregulation in osteogenic lineage cells, which promoted Rb dephosphorylation and aberrant Smad2/3 phosphorylation, thereby suppressing Runx2-mediated osteogenesis. p21 inhibition reversed this cascade and restored osteogenic differentiation. Local delivery of UC2288@AlgMA significantly enhanced bone regeneration.Conclusion: p21-related signaling impairs bone healing after irradiation, and local UC2288 delivery via AlgMA hydrogels represents a viable strategy to enhance ORNJ regeneration.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Aggressive Mandibular Lesion With Torus-Like Presentation: A Diagnostic Challenge in Early Clinical Assessment. 具有环状表现的侵袭性下颌病变：早期临床评估的诊断挑战。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70455

Federico Garola, Gerardo Gilligan, Carlos Marcelo Cerullo

引用次数: 0

Margin-To-Depth-Of-Invasion Ratio: A Paradigm Shift in Oral Cancer Margin Assessment. 边缘-浸润深度比：口腔癌边缘评估的范式转变。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-12 DOI: 10.1111/odi.70461

Chun-Yang Hung, Li-Jen Liao, Tseng-Cheng Chen

{"title":"Margin-To-Depth-Of-Invasion Ratio: A Paradigm Shift in Oral Cancer Margin Assessment.","authors":"Chun-Yang Hung, Li-Jen Liao, Tseng-Cheng Chen","doi":"10.1111/odi.70461","DOIUrl":"10.1111/odi.70461","url":null,"abstract":"Objective: Surgical margin status and depth of invasion are established prognostic factors in oral squamous cell carcinoma, yet an adequate margin remains undefined. A fixed 5 mm threshold is applied to tumors of widely varying depth. We examined the margin-to-depth-of-invasion ratio, the closest surgical margin divided by the depth of invasion, as a tumor-proportional alternative.Methods: We synthesized two retrospective studies: a single-institution cohort of 911 patients with early-stage disease, and a nationwide registry cohort of 7420 patients with node-negative disease across all tumor classifications, each stratified by margin distance and by ratio (below 0.5 versus 0.5 or greater).Results: A ratio below 0.5 predicted higher local recurrence among non-positive margins (odds ratio 2.81). Five-year disease-free survival was 80.8% with clear margins, 76.3% with close margins and a ratio of 0.5 or greater, and 65.2% with close margins and a ratio below 0.5. Nationwide, both subgroups with a ratio of 0.5 or greater showed superior survival regardless of margin distance. Postoperative radiotherapy improved disease-free survival only when the ratio was below 0.5.Conclusions: The margin-to-depth-of-invasion ratio reframes margin adequacy as proportional rather than absolute. A ratio of 0.5 distinguishes high-risk from low-risk margins and identifies candidates for postoperative radiotherapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Periodontitis and Respiratory Diseases: A Systematic Umbrella Meta-Analysis. 牙周炎与呼吸系统疾病之间的关系：一项系统的综合meta分析。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-11 DOI: 10.1111/odi.70448

Shahen Hiwa Omer, Mohammed Khalid Mahmood, Sarhang Sarwat Gul, Yad Mariwan Mohammed Amin, Romain Lan

{"title":"Association Between Periodontitis and Respiratory Diseases: A Systematic Umbrella Meta-Analysis.","authors":"Shahen Hiwa Omer, Mohammed Khalid Mahmood, Sarhang Sarwat Gul, Yad Mariwan Mohammed Amin, Romain Lan","doi":"10.1111/odi.70448","DOIUrl":"https://doi.org/10.1111/odi.70448","url":null,"abstract":"Aim: This study aimed to evaluate the association between periodontitis and respiratory diseases using an umbrella meta-analysis.Methods: Meta-analyses (MAs) reporting odds ratios (OR) and mean differences (MD) for the association between periodontitis and respiratory diseases of COVID-19, chronic obstructive pulmonary disease (COPD), asthma, and pneumonia were included. Random-effects meta-analysis was performed. Egger's test and trim-and-fill method were used to assess publication bias.Results: Fourteen MAs encompassing more than 500,000 participants were included. A significant association was found between periodontitis and respiratory disease (OR 2.45, 95% CI 2.06-2.92, p < 0.0001), with substantial heterogeneity (I2 = 82%). The pooled OR for the association between periodontitis with COVID-19, COPD, asthma, and pneumonia was 2.75, 1.42, 3.42, and 2.73, respectively. The association remained consistent even after adjustment for publication bias and among different study qualities and sample sizes. Notably, the association with COPD may not be independent of smoking. The GRADE assessment rated the certainty of evidence of the outcomes as \"low\" due to high heterogeneity and publication bias.Conclusions: The results suggest a statistical association between periodontitis and most of the studied respiratory diseases. However, these results should be interpreted with caution and be seen as exploratory and hypothesis-generating, rather than definitive effect sizes.Prospero registration: CRD420251250830.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring Mouth Opening in Systemic Sclerosis: A Scoping Review of Interventions. 恢复系统性硬化症患者的开口：干预措施的范围综述。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-08-11 DOI: 10.1111/odi.70451

Beatriz Borba Barros Bernardo, Lucas Nascimento Ribeiro, Luiz Alcino Monteiro Gueiros, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas Moraes, Marianne Vasconcelos Carvalho

{"title":"Restoring Mouth Opening in Systemic Sclerosis: A Scoping Review of Interventions.","authors":"Beatriz Borba Barros Bernardo, Lucas Nascimento Ribeiro, Luiz Alcino Monteiro Gueiros, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas Moraes, Marianne Vasconcelos Carvalho","doi":"10.1111/odi.70451","DOIUrl":"https://doi.org/10.1111/odi.70451","url":null,"abstract":"Objectives: To map and characterize the therapeutic strategies described in the literature for the management of microstomia in patients with systemic sclerosis.Methods: This scoping review was conducted in accordance with the PRISMA-ScR guidelines. Searches were performed in Medline/PubMed, Embase, Scopus, Web of Science, Cochrane Library, and gray literature searches. Studies involving adults with systemic sclerosis of any subtype who received local or systemic interventions aimed at improving microstomia and reported at least one mouth opening-related outcome were eligible.Results: Forty-five studies were included. Non-surgical interventions predominated, including physiotherapy, injectables, and oral medications, whereas surgical treatments were less frequently reported and mainly involved autologous fat grafting. Randomized controlled trials primarily evaluated conservative interventions, while surgical approaches were mostly investigated in quasi-experimental studies. Heterogeneity was observed across study designs, outcome measures, follow-up durations, and assessment instruments. Objective measures of mouth opening, especially interincisal distance, were the most reported outcomes.Conclusions: The available evidence on microstomia management in systemic sclerosis is predominantly based on non-surgical interventions and is marked by substantial methodological heterogeneity. Future research should prioritize standardized outcome measures, longer follow-up periods, and well-designed multicenter studies to better define the role of conservative and surgical treatments in this clinical setting.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0