Oral diseases最新文献_第10页

Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective. 灼口综合征的潜在因素：从网络角度的路线图。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-13 DOI: 10.1111/odi.15219

Oscar Gabriel Castaño-Joaqui, Laura Jiménez Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo

{"title":"Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.","authors":"Oscar Gabriel Castaño-Joaqui, Laura Jiménez Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo","doi":"10.1111/odi.15219","DOIUrl":"10.1111/odi.15219","url":null,"abstract":"Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS).Subjects and methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).Results: The structure of the associative pathways with the BMS was revealed. Direct associations involved Gastrointestinal Alterations (0.23), Vitamin D Deficiency (0.29), Musculoskeletal Alterations (0.29), Symptom Severity Score 2 (SSS2) (0.22), Cortisol Variation (0.10), Interpersonal Sensitivity (0.04), Hostility (0.03). Global Severity Index, Symptom Severity Score 1, Psychoticism, Obsession-Compulsion, Depression, Anxiety, and Somatization were indirectly related. The SSS2 was the most influential on BMS accuracy.Conclusions: Gastrointestinal alterations and vitamin D deficiency show a significant influence on BMS while cortisol mediates in multiple associative pathways between musculoskeletal alterations, gastrointestinal alterations, vitamin D deficiency, non-restorative sleep, fatigue, and cognitive problems. In addition to anxiety and depression, psychoticism, interpersonal sensitivity, and hostility stand out as psychological factors that seem to be related to a lack of vitamin D. None of the factors studied seem to have a relevant predictive potential for BMS, except for nonspecific symptoms of central sensitization.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1861-1875"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nomogram to Predict Mortality in Patients With Severe Oral and Maxillofacial Space Infections. 预测严重口腔颌面间隙感染患者死亡率的Nomogram。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-08 DOI: 10.1111/odi.15256

Hanyi Zhu, Wentao Qian, Yanxiang Li, Zhiyuan He, Huan Shi, Baoli Wang

{"title":"A Nomogram to Predict Mortality in Patients With Severe Oral and Maxillofacial Space Infections.","authors":"Hanyi Zhu, Wentao Qian, Yanxiang Li, Zhiyuan He, Huan Shi, Baoli Wang","doi":"10.1111/odi.15256","DOIUrl":"10.1111/odi.15256","url":null,"abstract":"Objective: This study aimed to explore the risk factors for death in extremely severe oral and maxillofacial space infection (OMSI) patients and to use these findings to establish a nomogram model that can be used to predict individual patient prognosis.Methods: Patients with extremely severe OMSI seen between 2020 and 2024 were enrolled (N = 102). Univariate and multivariate logistic regression were used to analyse the associations between clinical factors and the risk of death, and a nomogram was developed to visualise the model. Model accuracy and clinical utility of the nomogram was evaluated using receiver operating characteristic (ROC) curves, calibration curve and decision curve analysis (DCA).Results: Six variables were associated with death. Three independent risk factors for death were identified by multivariate logistic regression: history of rheumatoid arthritis (RA) (OR: 7.716; 95% CI: 0.988-52.122; p = 0.050), D-dimer (OR: 1.162; 95% CI: 1.048-1.28; p = 0.004), and serum creatinine level (OR: 1.011; 95% CI: 1.002-1.020; p = 0.018). The nomogram had an area under the receiver operating characteristic curve (AUC) of 0.819.Conclusion: A history of RA, D-dimer and serum creatinine are independent prognostic factors for overall survival in OMSI patients. The nomogram model showed good concordance and accuracy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1880-1889"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simplified Jaw Functional Limitation Scale for Temporomandibular Disorders: Psychometric Evaluation. 颞下颌障碍的简化颌功能限制量表：心理测量评估。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-10 DOI: 10.1111/odi.15253

Ruonan Sun, Tiqian Liu, Yiwei Liu, Shuyuan Zhang, Yuan Yue, Nan Jiang, Liming Zhang, Xin Xiong

{"title":"Simplified Jaw Functional Limitation Scale for Temporomandibular Disorders: Psychometric Evaluation.","authors":"Ruonan Sun, Tiqian Liu, Yiwei Liu, Shuyuan Zhang, Yuan Yue, Nan Jiang, Liming Zhang, Xin Xiong","doi":"10.1111/odi.15253","DOIUrl":"10.1111/odi.15253","url":null,"abstract":"Objective: This study aimed to simplify the Jaw Functional Limitation Scale (JFLS) and evaluate its reliability and validity in assessing jaw function in patients with temporomandibular disorders (TMD) in primary care.Methods: TMD patients and non-TMD participants were assessed using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Demographic data and the 8-item JFLS questionnaire were collected to quantify jaw functional restriction. Confirmatory factor analysis tested the validity of JFLS-8 using chi-square, comparative fit index (CFI), root mean square error of approximation (RMSEA), and root mean square residual (RMR). The study selected key items from each domain to create a 4-item JFLS for further testing. Exploratory factor analysis, reliability, and validity tests were conducted.Results: Analysis included 671 valid questionnaires (502 TMD patients, 169 non-TMD participants). JFLS-8 exhibited satisfactory fit among TMD patients (RMSEA = 0.143, CFI = 0.881, RMR = 0.567). JFLS-4 retained items with high factor loadings: JFLS1 (0.935), JFLS2 (0.923), JFLS7 (0.766), and JFLS5 (0.713). The simplified JFLS-4 showed good reliability (Cronbach's alpha 0.714) and validity (Kaiser-Meyer-Olkin 0.558, Bartlett's test < 0.001) among TMD patients.Conclusion: A 4-item JFLS was developed and validated, demonstrating good reliability and validity in assessing mandibular function in TMD patients, exhibiting the potential to streamline evaluation processes in clinical practice.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1854-1860"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmed Cell Death Tunes Periodontitis. 程序性细胞死亡与牙周炎有关。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-23 DOI: 10.1111/odi.15248

Yuejiao Xin, Yixiang Wang

{"title":"Programmed Cell Death Tunes Periodontitis.","authors":"Yuejiao Xin, Yixiang Wang","doi":"10.1111/odi.15248","DOIUrl":"10.1111/odi.15248","url":null,"abstract":"Objective: To review current knowledge of the various processes of programmed cell death and their roles in immunoregulation in periodontitis.Methods: Relevant literature in the PubMed, Medline, and Scopus databases was searched, and a narrative review was performed. Programmed cell death and the regulation of its various pathways implicated in periodontal infection were reviewed.Results: Multicellular organisms dispose of unnecessary or damaged cells via programmed cell death. Programmed cell death lies at the core of the balance of cell death and survival in pathological progress and infection. Periodontitis is a complex infectious disease involving virulence factors of periodontal pathogens and tightly regulated immune responses of the host. Different types of programmed cell death can play opposite roles in periodontitis or exert their action combinatorially.Conclusion: The coordinated system of various programmed cell death pathways and the extensive crosstalk among them play a fundamental role in the pathophysiology of periodontitis. Illuminating the precise roles and mechanisms of programmed cell death in periodontitis could open up novel therapeutic approaches.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1583-1594"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variants Influence the Severity of Oral Mucositis in Pediatric Osteosarcoma Patients. 遗传变异影响儿童骨肉瘤患者口腔黏膜炎的严重程度。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-10 DOI: 10.1111/odi.15217

Renata de Almeida Zieger, Mariana Rodrigues Botton, Marina Curra, Amanda de Farias Gabriel, Stefanie Thieme, Luisa Comerlato Jardim, Marco Antonio Trevizani Martins, Ursula da Silveira Matte, André Tesainer Brunetto, Lauro José Gregianin, Rafael Roesler, Stephen T Sonis, Marina Siebert, Manoela Domingues Martins

{"title":"Genetic Variants Influence the Severity of Oral Mucositis in Pediatric Osteosarcoma Patients.","authors":"Renata de Almeida Zieger, Mariana Rodrigues Botton, Marina Curra, Amanda de Farias Gabriel, Stefanie Thieme, Luisa Comerlato Jardim, Marco Antonio Trevizani Martins, Ursula da Silveira Matte, André Tesainer Brunetto, Lauro José Gregianin, Rafael Roesler, Stephen T Sonis, Marina Siebert, Manoela Domingues Martins","doi":"10.1111/odi.15217","DOIUrl":"10.1111/odi.15217","url":null,"abstract":"Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).Methods: A longitudinal observational retrospective study was conducted. Severity of OM was assessed daily using World Health Organization (WHO) criteria. Blood samples were collected, and DNA was extracted. 54 coding regions were analyzed for 17 candidate genes using next-generation sequencing.Results: A total of 164 CT cycles were evaluated in 14 pediatric patients being treated for OS with HDMTX (66.9%) and doxorubicin + cisplatin (34.1%). OM was diagnosed in 129 cycles (78.7%). Whereas the presence of OM was associated with ABCA3 (rs13332514) in HDMTX cycles, OM severity was associated with ABCC2 (rs2273697) in multivariate analysis. In doxorubicin + cisplatin, genetic variants of ABC family genes (ABCC2 and ABCC6) were associated with OM in multivariate analysis.Conclusion: Oral mucositis risk and severity in a pediatric population being treated for OS with HDMTX, doxorubicin, and cisplatin were associated with genes in the ABC family (ABCA3, ABCC2, and ABCC6 genes).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1765-1775"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint. zymosan治疗SKG小鼠：评估全身性炎症对颞下颌关节的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-30 DOI: 10.1111/odi.15242

Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimura, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi

{"title":"Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.","authors":"Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimura, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi","doi":"10.1111/odi.15242","DOIUrl":"10.1111/odi.15242","url":null,"abstract":"Objectives: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ.Materials and methods: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed.Results: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities.Conclusions: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1831-1840"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Surgical Treatment Compared With "Wait and See" in Patients Affected by Oral Leukoplakia to Prevent Oral Cancer: Preliminary Data From a Multicenter Randomized Controlled Trial. 点评：口腔白斑患者手术治疗与“观望”预防口腔癌的比较：一项多中心随机对照试验的初步数据。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-30 DOI: 10.1111/odi.15230

Wei Liu, Xuemin Shen, Linjun Shi

引用次数: 0

Validity and Utility of a Risk Prediction Model for Wound Infection After Lower Third Molar Surgery. 下第三磨牙手术后伤口感染风险预测模型的有效性和实用性。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-10 DOI: 10.1111/odi.15243

Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Keisuke Okamoto, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi

{"title":"Validity and Utility of a Risk Prediction Model for Wound Infection After Lower Third Molar Surgery.","authors":"Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Keisuke Okamoto, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi","doi":"10.1111/odi.15243","DOIUrl":"10.1111/odi.15243","url":null,"abstract":"Objectives: To externally validate a clinical prediction model for surgical site infection (SSI) after lower third molar (L3M) surgery and evaluate its clinical usefulness.Methods: We conducted a retrospective cohort study of patients who underwent L3M surgery at Hokkaido University Hospital. The study was designed to evaluate the historical and methodological transportability. Clinical usefulness was evaluated using decision curve analysis on the data of the non-antibiotic-treated patients.Results: We obtained 2543 validation cohorts from April 2020 to March 2023, and 640 non-antibiotic cohorts from July 2010 to September 2023. The incidences of SSI after L3M surgery were 5.3% (135/2543) and 7.7% (49/640) in the validation and non-antibiotic cohorts, respectively. The discrimination ability of the prediction model was acceptable for the external validation cohort (c-statistic: 0.67; 95% CI: 0.62-0.71) and adequate for the non-antibiotic cohort (c-statistic: 0.72; 95% CI: 0.63-0.79). In both cohorts, the model showed excellent calibration between the observed and predicted probabilities. Decision curve analysis showed increased net benefit across a range of meaningful risk thresholds.Conclusion: A simple risk prediction model for SSI after L3M surgery demonstrated clinical transportability and usefulness. This model may help surgeons/clinicians determine the appropriateness of prophylactic antibiotics administration for patients in L3M surgery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1922-1931"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis. 植物化学物质对口腔癌转移影响的临床前和临床证据。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1111/odi.15293

Murugesan Amirtha Varshini, Arikketh Devi

{"title":"Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis.","authors":"Murugesan Amirtha Varshini, Arikketh Devi","doi":"10.1111/odi.15293","DOIUrl":"10.1111/odi.15293","url":null,"abstract":"Objective: This review focuses on the clinical and preclinical studies pertaining to the use of phytochemicals in the prevention of Oral Squamous Cell Carcinoma (OSCC) metastasis.Methods: A thorough overview of the relevant literature was provided by the narrative review approach. The PubMed, Google Scholar, and Scopus databases were used to retrieve publications on the phytochemicals preventing oral cancer metastasis. Clinical trials of phytochemicals on oral cancer patients were retrieved from https://clinicaltrials.gov/.Results: An increasing number of scientific literature provides evidence suggesting that phytochemicals might possess the capacity to impede cancer invasion and metastasis. Plant extracts and phytochemical substances, including genistein, curcumin, lycopene, resveratrol, isothiocyanates, and green tea extract, have shown promise in recent novel research as potential weapons against this cancer.Conclusion: A crucial prognostic factor for oral cancer is distant metastasis (DM). Chemoprevention is a comprehensive concept that encompasses the use of synthetic or natural substances to impede the development or progression of cancer. This current literature review enumerates the data supporting these potential phytochemicals' benefits in OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1564-1582"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth Loss. 口腔白斑微生物组预测发育不良的程度，并由吸烟和牙齿脱落形成。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-02-04 DOI: 10.1111/odi.15272

Sheila Galvin, Bahman Honari, Sviatlana Anishchuk, Claire M Healy, Gary P Moran

{"title":"Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth Loss.","authors":"Sheila Galvin, Bahman Honari, Sviatlana Anishchuk, Claire M Healy, Gary P Moran","doi":"10.1111/odi.15272","DOIUrl":"10.1111/odi.15272","url":null,"abstract":"Objective: This study aimed to determine if the oral potentially malignant disorder, oral leukoplakia (OLK), exhibited microbiome changes that predict the degree of dysplasia and the risk of malignant progression.Results: We examined the microbiome in 216 swabs of OLK from 177 patients. Compared to healthy controls (n = 120 swabs from 61 patients), who were less likely to smoke and had better oral health, OLK patients exhibited an increased abundance of Rothia mucilaginosa, Streptococcus parasanguinis and S. salivarius, resembling acetaldehyde generating communities described previously. Compared to the patients' healthy contralateral normal (CLN) mucosa (n = 202), which acts as a matched control for oral health parameters, OLK exhibited increased S. infantis, Leptotrichia spp., Bergeyella spp., Porphyromonas spp. and F. nucleatum. Machine learning with clinical and microbiome data could discriminate high-risk dysplasia (moderate to severe) from low-risk dysplasia (none or mild) (sensitivity 87.4%; specificity 76.5%). Follow-up swabs were recovered from 58 patients, eight of whom progressed to a higher grade of dysplasia or OSCC and these eight patients exhibited a higher abundance of Fusobacterium species at their initial presentation.Conclusions: Our study suggests that the OLK microbiome has potential to be an aid to the prediction of dysplasia grade and the risk of malignant transformation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1704-1716"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0