Oral diseases最新文献_第10页

Reply to Accurate Risk Prediction Model for Surgical Site Infection After Lower Third Molar Surgery. 回复 "下第三磨牙手术后手术部位感染的准确风险预测模型"。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-03 DOI: 10.1111/odi.15184

Akira Yamagami, Katsuya Narumi, Yoshitaka Saito, Ayako Furugen, Shungo Imai, Yoshimasa Kitagawa, Yoichi Ohiro, Ryo Takagi, Yoh Takekuma, Mitsuru Sugawara, Masaki Kobayashi

引用次数: 0

Telediagnosis in Pediatric Stomatology: Impact on Referrals and Healthcare Network. 小儿口腔科的远程诊断：对转诊和医疗网络的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-03 DOI: 10.1111/odi.15175

Michelle Roxo-Gonçalves, Pâmela de Souza Kargwanski, Ingrid Silva Santos, Caren Serra Bavaresco, Adriela Azevedo Souza Mariath, Marco Antonio Trevizani Martins, Manoela Domingues Martins, Roberto Nunes Umpierre, Vinicius C Carrard

引用次数: 0

Benzylurea Protects hPDLFs Against LPS-Induced Mitochondrial Dysfunction Through MTCH2. 苄脲通过 MTCH2 保护 hPDLFs 免受 LPS 诱导的线粒体功能障碍的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-03 DOI: 10.1111/odi.15172

Li Liu, Jing Bai, Jiyun Wang, Junheng Fan, Dong Yin, Hong Chang, Xuancheng Hui, Pengfei Yang

{"title":"Benzylurea Protects hPDLFs Against LPS-Induced Mitochondrial Dysfunction Through MTCH2.","authors":"Li Liu, Jing Bai, Jiyun Wang, Junheng Fan, Dong Yin, Hong Chang, Xuancheng Hui, Pengfei Yang","doi":"10.1111/odi.15172","DOIUrl":"https://doi.org/10.1111/odi.15172","url":null,"abstract":"Objective: The aim of this study is to explore the mechanism of benzylurea in the inflammatory injury of human periodontal ligament fibroblasts (hPDLFs).Methods: An inflammation model of hPDLFs was established using LPS. Nuclear transport of nuclear transcription factor-κB (NF-κB), secretion of cytokines, and the morphology and distribution of F-actin were determined. Mitochondrial function was assessed by measuring mitochondrial membrane potential (MMP), mitochondrial permeability transition pore (mPTP), and reactive oxygen species (ROS) levels. The expression of mitochondrial carrier homolog 2 (MTCH2) and Cytochrome b5 type B (CYB5B) was detected.Results: Benzylurea alleviated the effects of lipopolysaccharide (LPS) on the proliferation and apoptosis of hPDLFs. It reduced the release of inflammatory cytokines and inhibited NF-κB nuclear translocation. Benzylurea improved mitochondrial function by regulating MMP and preventing excessive mPTP opening. Furthermore, LPS elevated the expression of MTCH2 and reduced the expression of CYB5B in hPDLFs. However, these effects can be inhibited by benzylurea. The altered expression of MTCH2 directly affected CYB5B expression, the release of inflammatory cytokines, and the activation of nuclear translocation of NF-κB.Conclusion: CYB5B may act as an effector of MTCH2, with benzylurea enhancing mitochondrial function and protecting hPDLFs from LPS-induced injury through MTCH2.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases. 口腔扁平苔藓患者的自身免疫和上皮发育不良。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-19 DOI: 10.1111/odi.14988

Jeong-Hyun Kang, Ji Eun Kwon

{"title":"Autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases.","authors":"Jeong-Hyun Kang, Ji Eun Kwon","doi":"10.1111/odi.14988","DOIUrl":"10.1111/odi.14988","url":null,"abstract":"Objectives: The primary objective of this study was to explore relationship between autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases.Materials and methods: A total of 66 patients with oral lichen planus (OLP), 35 with oral lichenoid lesion (OLL), and 85 with oral lichenoid drug reaction (OLDR) were enrolled. OLP, OLL, and OLDR were diagnosed following the definitions of the modified World Health Organization criteria, except for the absence of epithelial dysplasia. All patients underwent diagnostic incisional biopsy and adjunctive direct immunofluorescence assays. An indirect immunofluorescence assay was conducted to determine the antinuclear antibody (ANA) positivity.Results: OLP and OLDR patients with epithelial dysplasia demonstrated higher prevalence of serum ANA positivity compared to those without epithelial dysplasia. Elevated serum levels of high sensitivity-C reactive proteins were observed in the OLP, OLL, and OLDR patients with epithelial dysplasia. In the DIF analysis, patients with epithelial dysplasia in the OLP exhibited a higher prevalence of C3 deposition in the basement membrane zone.Conclusions: This study proposed that autoimmunity may contribute to elevating levels of focal and chronic systemic inflammation, potentially influencing abnormal wound healing and development of dysplastic changes in the oral epithelium among patients with oral lichenoid disease.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"5091-5101"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA EIF3J-DT promotes chemoresistance in oral squamous cell carcinoma. LncRNA EIF3J-DT 促进口腔鳞状细胞癌的化疗耐药性

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-30 DOI: 10.1111/odi.14987

Seon Hyun Kim, Hye Jung Kim, Yeong Joo Kim, Yun Hak Kim, Hae Ryoun Park

{"title":"LncRNA EIF3J-DT promotes chemoresistance in oral squamous cell carcinoma.","authors":"Seon Hyun Kim, Hye Jung Kim, Yeong Joo Kim, Yun Hak Kim, Hae Ryoun Park","doi":"10.1111/odi.14987","DOIUrl":"10.1111/odi.14987","url":null,"abstract":"Objectives: This study aimed to screen oral squamous cell carcinoma (OSCC) diagnostic and prognostic candidates and investigate the potential functions and mechanisms of candidates in the chemoresistance of OSCC cell lines.Materials and methods: Differential expression profiling of lncRNA was performed in a large cohort of OSCC patients from the Cancer Genome Atlas database to identify OSCC diagnostic and prognostic candidates. Taxol resistance in OSCC cell lines was analyzed using MTT assay. OSCC cell lines transfected with EIF3J-DT pcDNA or siRNA were used to determine its regulatory effects on apoptosis, cell cycle distribution and autophagy using flow cytometry and western blot.Results: We identified EIF3J-DT as a candidate for OSCC diagnosis and prognosis. The expression level of EIF3J-DT in OSCC cell lines correlates with taxol resistance. EIF3J-DT silencing attenuated taxol resistance, and EIF3J-DT overexpression enhanced taxol resistance in OSCC cell lines. Silencing of EIF3J-DT reduced taxol resistance by inducing apoptosis, cell cycle arrest, and ATG14-mediated autophagy inhibition in OSCC cell lines.Conclusions: We found that EIF3J-DT induced chemoresistance by regulating apoptosis, cell cycle, and autophagy in OSCC cell lines, which EIF3J-DT might provide a novel therapeutic approach for OSCC as well as a diagnostic and prognostic factor.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4909-4920"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Letter to the Editor. 回复致编辑的信。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-22 DOI: 10.1111/odi.14996

Marta Vilar Villanueva, José Manuel Somoza Martín, Andrés Blanco Carrión, Abel García García, Tamara García Carnicero, Xabier Marichalar Mendía, Mercedes Gallas Torreira, Pilar Gándara Vila

引用次数: 0

Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta-analysis. 评估人乳头瘤病毒在口腔癌中因果作用的偏差：系统回顾和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-07-02 DOI: 10.1111/odi.15062

Gagandeep Kaur, Tami Yap, Rishi Ramani, Michael McCullough, Ankur Singh

{"title":"Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta-analysis.","authors":"Gagandeep Kaur, Tami Yap, Rishi Ramani, Michael McCullough, Ankur Singh","doi":"10.1111/odi.15062","DOIUrl":"10.1111/odi.15062","url":null,"abstract":"Objective: High-risk human papillomaviruses (HPV) are an established cause of oropharyngeal cancer. Their relationship with oral cancer remains unclear with detection ranging from 0% to 100%. HPV DNA detection or evidence of exposure alone is insufficient to conclude causality. This systematic review assesses the extent of bias in studies of HPV detection in cancers of the oral cavity.Methods: PubMed, Ovid MEDLINE, EMBASE, and PsycInfo databases were searched for observational studies reporting the effect of HPV in oral cavity specific cancers.Results: All 15 included studies presented HPV DNA detection or serum HPV-antibodies, none included mRNA E6/E7 analysis. Cases with oral cancer had 5.36 times (95% CI 3.29-8.72) higher odds of having HPV detected compared to controls. The odds of HPV detection were higher in cell-based (OR 6.93; 95% CI 0.82-58.55) and tissue samples (OR 5.28; 95% CI 3.41-8.18) than blood-based samples (OR 3.36; 95% CI 1.53-7.40).Conclusion: When cancer site is clearly differentiated between oropharynx and oral cavity, 12 studies showed strong association between HPV and oral cancer, but the available estimates lack internal validity due to inconsistent measurements, high confounding, and lack of gold standard testing. There is not high-quality evidence to conclude a causal relationship of HPV with oral cancer.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"5379-5387"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis. 多部位上皮发育不良的组织病理学风险评估：一项荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-06-30 DOI: 10.1111/odi.15052

Daniel Lobato Ferreira Ferraz, Erison Santana Dos Santos, Caique Mariano Pedroso, Brunno Santos de Freitas Silva, Omar Kujan, Tuula Anneli Salo, Mohammed I Malki, Susanna Juteau, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva

{"title":"Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis.","authors":"Daniel Lobato Ferreira Ferraz, Erison Santana Dos Santos, Caique Mariano Pedroso, Brunno Santos de Freitas Silva, Omar Kujan, Tuula Anneli Salo, Mohammed I Malki, Susanna Juteau, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva","doi":"10.1111/odi.15052","DOIUrl":"10.1111/odi.15052","url":null,"abstract":"Objective: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.Methods: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.Results: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.Conclusions: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4821-4829"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of MRONJ risk after exodontia by virtue of ozone infiltration: A randomized clinical trial. 通过臭氧浸润降低牙齿外翻后的 MRONJ 风险：随机临床试验

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI: 10.1111/odi.15006

Olga Di Fede, Gaetano La Mantia, Carmine Del Gaizo, Rodolfo Mauceri, Domenica Matranga, Giuseppina Campisi

{"title":"Reduction of MRONJ risk after exodontia by virtue of ozone infiltration: A randomized clinical trial.","authors":"Olga Di Fede, Gaetano La Mantia, Carmine Del Gaizo, Rodolfo Mauceri, Domenica Matranga, Giuseppina Campisi","doi":"10.1111/odi.15006","DOIUrl":"10.1111/odi.15006","url":null,"abstract":"Introduction: Exodontia is commonly considered as a risk factor for the development of medication-related osteonecrosis of the jaw (MRONJ) in individuals exposed to bone modifying agents. This study was aimed at assessing the efficiency and safety of a gaseous oxygen-ozone mixture as an adjuvant to a standard exodontia to reduce the risk of MRONJ development.Methods: A randomized, open-label, phase II, single-center clinical trial involving 117 patients at risk of MRONJ was conducted. The study protocol tested injections of an oxygen-ozone mixture in the post-extraction site. Participants were randomly assigned to two groups: oxygen-ozone therapy, and standard tooth extraction protocol. Post-extraction wound healing was assessed using the Inflammatory Proliferative Remodeling (IPR) Wound Healing Scale.Results: The oxygen-ozone therapy group exhibited a significant improvement in wound healing post-extraction during the inflammatory and proliferative phases, as indicated by the IPR scale scores at 3-5 days (p = 0.006) and 14 days (p < 0.001) respectively.Conclusion: Oxygen-ozone therapy shows promise in improving post-extraction healing in patients at risk of MRONJ. Future studies with larger sample sizes and multicenter collaborations are recommended to confirm the validity of these findings and explore the long-term efficacy of ozone therapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"5183-5194"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multidimensional impact of burning mouth syndrome on patients and their families. 灼口综合征对患者及其家庭的多方面影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-07-10 DOI: 10.1111/odi.15072

Alan Roger Santos-Silva, Alessandro Villa

引用次数: 0