Manifestations of Head and Neck Cancer in Patients With Plummer-Vinson Syndrome: A Systematic Review.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-01-06 DOI:10.1111/odi.15224

Brunno Santos de Freitas Silva, Débora Peclat Souza, Alessah Carolyna de Andrade Fernandes, Larissa Rosa Santana Rodrigues, Omar Kujan, Fernanda Paula Yamamoto-Silva

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引用次数: 0

Abstract

Objective: To investigate the clinical manifestations of head and neck cancer in patients with Plummer-Vinson syndrome (PVS) and to assess related oral comorbidities.

Materials and methods: Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two-phase selection process.

Results: Out of a total of 19,183 citations identified, seven met the inclusion criteria. Prevalent symptoms included dysphagia and esophageal webs, with atrophic glossitis and angular cheilitis being common oral manifestations. Most patients presented with long-standing iron deficiency anemia. Head and neck cancers predominantly affected the pharynx and tongue borders, with younger age groups notably affected. The overall risk of bias attributable to the quality of the reports was assessed as "low".

Conclusions: Despite the rarity of PVS-related head and neck cancer, this review underscores its association, particularly in younger patients. A thorough examination of dysphagia and oral manifestations in PVS patients is crucial for early detection and prevention of head and neck cancer.

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.