Differences in Oral Squamous Cell Carcinoma From Colombia and Spain: A Retrospective Cohort Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-02-17 DOI:10.1111/odi.15292

Ana María Rochel-Rochel, Julio Acero-Sanz, Juan Carlos de Vicente, Vito Carlo Alberto Caponio, Cristina Cárdenas-Serres, Catalina Cáceres Ramírez, Silvia Juliana Villabona Flórez, Viviana Jiménez Andrade, Diego Gómez Abreu, Francy Archilla Flórez, Rosa María López-Pintor

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引用次数: 0

Abstract

Objective: To compare the clinicopathological characteristics and survival of two cohorts of patients with oral squamous cell carcinoma (OSCC) from Spain and Colombia.

Methods: Clinicopathological and survival variables of patients with OSCC from six maxillofacial surgery departments in Spain and Colombia were retrospectively reviewed. Variables were compared according to country of origin.

Results: We included 649 patients, 359 from Spain and 290 from Colombia. The Colombian cohort was younger, drank more alcohol, had less comorbidities, and reported a greater mean number of days both from symptoms to diagnosis and from then to treatment, which was ∼2.5 times longer in the Colombian cohort. Colombian patients were diagnosed at a more advanced stage. The treatment of choice was resective surgery. In the Colombian cohort, more patients received radio and chemotherapy together with surgery. Second primary tumors and recurrences were more frequent in the Colombian sample (7.2% vs. 2.8%; p = 0.008) and in the Spanish cohort (32% vs. 23.1%; p = 0.012), respectively. Overall survival was similar between the two samples (HR = 1.15; 95% CI = 0.93-1.42; p = 0.195) and disease-specific survival was worse in the Colombian one (HR = 1.30; 95% CI = 1.03-1.65; p = 0.027).

Conclusions: There were epidemiological differences between patients with OSCC in both cohorts and a longer delay in diagnosis and treatment in the Colombian sample.

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哥伦比亚和西班牙口腔鳞状细胞癌的差异：一项回顾性队列研究。

目的：比较西班牙和哥伦比亚两组口腔鳞状细胞癌（OSCC）患者的临床病理特征和生存率。方法：回顾性分析西班牙和哥伦比亚6个颌面外科收治的OSCC患者的临床病理和生存指标。根据原产国对变量进行比较。结果：纳入649例患者，其中359例来自西班牙，290例来自哥伦比亚。哥伦比亚队列更年轻，饮酒更多，合并症更少，并且从症状到诊断以及从诊断到治疗的平均天数更长，这在哥伦比亚队列中是2.5倍。哥伦比亚患者被诊断为晚期。治疗选择切除手术。在哥伦比亚队列中，更多的患者在接受手术的同时接受了放疗和化疗。第二原发肿瘤和复发率在哥伦比亚样本中更为常见(7.2% vs. 2.8%；p = 0.008)和西班牙队列(32% vs. 23.1%；P = 0.012)。两个样本的总生存率相似(HR = 1.15；95% ci = 0.93-1.42；p = 0.195)，哥伦比亚患者的疾病特异性生存率较差(HR = 1.30；95% ci = 1.03-1.65；p = 0.027)。结论：两组OSCC患者之间存在流行病学差异，哥伦比亚样本的诊断和治疗延迟较长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.