Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-03-03 DOI:10.1111/odi.15293

Murugesan Amirtha Varshini, Arikketh Devi

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引用次数: 0

Abstract

Objective: This review focuses on the clinical and preclinical studies pertaining to the use of phytochemicals in the prevention of Oral Squamous Cell Carcinoma (OSCC) metastasis.

Methods: A thorough overview of the relevant literature was provided by the narrative review approach. The PubMed, Google Scholar, and Scopus databases were used to retrieve publications on the phytochemicals preventing oral cancer metastasis. Clinical trials of phytochemicals on oral cancer patients were retrieved from https://clinicaltrials.gov/.

Results: An increasing number of scientific literature provides evidence suggesting that phytochemicals might possess the capacity to impede cancer invasion and metastasis. Plant extracts and phytochemical substances, including genistein, curcumin, lycopene, resveratrol, isothiocyanates, and green tea extract, have shown promise in recent novel research as potential weapons against this cancer.

Conclusion: A crucial prognostic factor for oral cancer is distant metastasis (DM). Chemoprevention is a comprehensive concept that encompasses the use of synthetic or natural substances to impede the development or progression of cancer. This current literature review enumerates the data supporting these potential phytochemicals' benefits in OSCC.

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植物化学物质对口腔癌转移影响的临床前和临床证据。

目的：本文综述了植物化学物质预防口腔鳞状细胞癌（OSCC）转移的临床和临床前研究。方法：采用叙事回顾法对相关文献进行全面综述。使用PubMed、谷歌Scholar和Scopus数据库检索有关植物化学物质预防口腔癌转移的出版物。植物化学物质对口腔癌患者的临床试验检索自https://clinicaltrials.gov/.Results：越来越多的科学文献提供证据表明植物化学物质可能具有阻止癌症侵袭和转移的能力。植物提取物和植物化学物质，包括染料木素、姜黄素、番茄红素、白藜芦醇、异硫氰酸酯和绿茶提取物，在最近的新研究中显示出作为对抗这种癌症的潜在武器的希望。结论：口腔癌远处转移是影响预后的重要因素。化学预防是一个综合概念，包括使用合成或天然物质来阻止癌症的发展或进展。当前的文献综述列举了支持这些潜在植物化学物质在OSCC中的益处的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.