Oral diseases最新文献_第9页

Trends in the Adoption of Terminology for Oral Potentially Malignant Disorders. 采用口腔潜在恶性疾病术语的趋势。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-31 DOI: 10.1111/odi.15332

Brunno Santos de Freitas Silva, Lucila Valadão Sant'ana Tertuliano Trovão, Eleazar Mezaiko, Tiago Paiva Prudente, Reuber Mendes Rocha, Alan Roger Santos-Silva, Saman Warnakulasuriya, Fernanda Paula Yamamoto-Silva

引用次数: 0

P. gingivalis OMVs Attenuate the Osteogenesis of PDLSCs by Activating PERK Signaling. 牙龈卟啉卟啉omv通过激活PERK信号减弱PDLSCs的成骨作用。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1111/odi.15320

Yingying Huang, Xiaoning He, Jiangwei Liao, Dihao Tao, Hanzhe Wang, Bei Li, Zhiwei Dong, Junjie Wu

{"title":"P. gingivalis OMVs Attenuate the Osteogenesis of PDLSCs by Activating PERK Signaling.","authors":"Yingying Huang, Xiaoning He, Jiangwei Liao, Dihao Tao, Hanzhe Wang, Bei Li, Zhiwei Dong, Junjie Wu","doi":"10.1111/odi.15320","DOIUrl":"10.1111/odi.15320","url":null,"abstract":"Objective: The Porphyromonas gingivalis outer membrane vesicles (P. gingivalis OMVs) carry toxins that contribute to the onset and progression of periodontitis. These OMVs have been implicated in host cell invasion and damage. This study aimed to determine the role and potential mechanisms of P. gingivalis OMVs on periodontal inflammation.Methods: A model of PDLSCs induced by P. gingivalis OMVs was developed, and changes in their biological functions were examined. We established a rat periodontitis model to confirm whether P. gingivalis OMV promotes the periodontal inflammatory phenotype. Additionally, the potential mechanisms by which P. gingivalis OMVs impair the osteogenic differentiation capacity of PDLSCs were investigated.Results: P. gingivalis OMVs inhibited the proliferation, promoted apoptosis and suppressed the osteogenesis of PDLSCs, while promoting periodontal inflammatory phenotype in vivo. Furthermore, mechanistic studies revealed that pretreatment of PDLSCs with 4-phenylbutyric acid (4-PBA) prevented the P. gingivalis OMVs-induced activation of the PERK pathway and restored the osteogenesis of PDLSCs.Conclusions: We demonstrate that P. gingivalis OMV exacerbates the periodontitis phenotype and inhibits the regenerative function of PDLSCs, potentially through mechanisms involving endoplasmic reticulum dysfunction.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2518-2530"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMURF1 Regulates Periodontal Stem Cell Injury and Osteogenic Differentiation by Regulating TRAF4. SMURF1通过调节TRAF4调控牙周干细胞损伤和成骨分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1111/odi.15341

Ziming Wei, Hui Xiao, Lishu Zhou, Yarong Wang

{"title":"SMURF1 Regulates Periodontal Stem Cell Injury and Osteogenic Differentiation by Regulating TRAF4.","authors":"Ziming Wei, Hui Xiao, Lishu Zhou, Yarong Wang","doi":"10.1111/odi.15341","DOIUrl":"10.1111/odi.15341","url":null,"abstract":"Objective: This study aimed to investigate the specific role and mechanistic actions of tumor necrosis factor receptor-associated factor 4 (TRAF4) in periodontitis.Methods: Human periodontal ligament stem cells (PDLSCs) were exposed to lipopolysaccharide (LPS). Then, real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting (WB) were carried out to determine the mRNA and protein expression levels of Smad ubiquitination regulator 1 (SMURF1). The relationship between TRAF4 and SMURF1, as predicted by the STRING and GeneMANIA databases, was verified by co-immunoprecipitation (Co-IP). Finally, both TRAF4 and SMURF1 were inhibited in PDLSCs by cell transfection, and the regulatory mechanisms involved were investigated by cell counting kit-8 assays, enzyme linked immunosorbent assay, WB, alkaline phosphatase, and alizarin red staining.Results: The gene and protein expression levels of SMURF1 in PDLSCs increased following LPS induction (p < 0.001); cell viability was decreased (p < 0.001), TRAF4 expression was decreased (p < 0.001), and cell-mineralized nodules were inhibited. Inhibition of SMURF1 expression increased PDLSCs activity and TRAF4 expression levels (p < 0.001), increased the number of cell-mineralized nodules, and enhanced cellular osteogenic capacity (p < 0.001).Conclusions: SMURF1 regulates LPS-stimulated injury and improves the capacity for osteogenic differentiation in PDLSCs by downregulating the expression of TRAF4.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2572-2583"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Non-Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis. 非手术治疗对III/IV期C级牙周炎血液学指标的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI: 10.1111/odi.15340

Xiaoyuan Guan, Xian-E Wang, Yi Li, Jingling Xu, Xinran Xu, Lu He, Li Xu, Huanxin Meng, Ruifang Lu

{"title":"Effects of Non-Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis.","authors":"Xiaoyuan Guan, Xian-E Wang, Yi Li, Jingling Xu, Xinran Xu, Lu He, Li Xu, Huanxin Meng, Ruifang Lu","doi":"10.1111/odi.15340","DOIUrl":"10.1111/odi.15340","url":null,"abstract":"Objective: To investigate the short-term effects of non-surgical periodontal treatment (NSPT) on clinical and hematological indices in stage III/IV grade C periodontitis patients.Methods: A total of 121 systemically healthy patients with generalized stage III/IV, grade C periodontitis were enrolled. Clinical indices (plaque index, probing depth, bleeding index, attachment loss) and hematological biomarkers [white blood cell count (WBC), mean platelet volume (MPV), neutrophil count (NEUT), neutrophil percentage (NEUT%), lymphocyte percentage (LYM%)] were measured before and 6-8 weeks after NSPT. Patients were divided into younger (≤ 35 years) and elder (> 35 years) groups, further stratified by systemic antibiotics usage. Analyses were performed using chi-squared tests, paired t-tests, and Pearson's correlation.Results: NSPT resulted in clinical indices improvement, as well as a reduction in WBC, NEUT, NEUT%, and an increase in MPV and LYM% in both groups. SRP-with-antibiotics subgroups showed more significant changes. SRP-without-antibiotics subgroups showed six significant correlations in both groups (p < 0.05); SRP-with-antibiotics subgroups showed 11 correlations in the younger and five in the elder group (p < 0.05).Conclusions: NSPT improved clinical and hematological outcomes in stage III/IV grade C periodontitis patients over 6-8 weeks. Younger patients exhibited more significant changes than elder patients, especially in the SRP-without-antibiotics subgroup.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2608-2618"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical Validation of Unsupervised Clustering for Adolescent TMD: A Cross-Sectional Study. 青少年TMD的无监督聚类的统计验证：一项横断面研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1111/odi.15331

Hye Kyoung Kim

{"title":"Statistical Validation of Unsupervised Clustering for Adolescent TMD: A Cross-Sectional Study.","authors":"Hye Kyoung Kim","doi":"10.1111/odi.15331","DOIUrl":"10.1111/odi.15331","url":null,"abstract":"Objective: This study employs unsupervised clustering to identify Temporomandibular disorders (TMD) phenotypes in adolescents, aiming to identify distinct clusters based on biopsychosocial features. It compares these clusters with conventional TMD classifications to assess if this method offers enhanced insights into TMD diagnosis.Methods: Data from 662 adolescent patients with TMD were analyzed using unsupervised clustering and classified into four groups based on DC/TMD Axis I: 1 (disc displacement), 2 (joint pain), 3 (muscle pain), and 4 (combined joint and muscle pain). Patient-reported outcomes were measured with instruments including the Brief Pain Inventory, the Pain Catastrophizing Scale, the Symptom Checklist-90-Revised, and the Pittsburgh Sleep Quality Index. Statistical analyses validated the clusters against conventional classifications.Results: Three distinct clusters were identified: High Impact (n = 70), Mild Symptoms (n = 423), and High Catastrophizing (n = 169), each displaying unique patterns in pain severity, pain catastrophizing, psychological distress, and sleep disturbances. Multinomial logistic regression of conventional TMD classifications revealed that only pain severity significantly differentiated the subcategories among these biopsychosocial factors.Conclusions: The findings underscore the variability in TMD presentations among adolescents and suggest that integrating phenotyping into the conventional diagnostic approach could significantly improve diagnostic accuracy and treatment outcomes, facilitating better management of high-risk adolescent patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2596-2607"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transgender Individuals in the Eyes of Dental Professionals: A Data-Driven Study. 牙科专业人员眼中的变性人：一项数据驱动的研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1111/odi.15310

Büşra Yılmaz, Hüseyin Sagman, Timur Köse, Gülnur Emingil

{"title":"Transgender Individuals in the Eyes of Dental Professionals: A Data-Driven Study.","authors":"Büşra Yılmaz, Hüseyin Sagman, Timur Köse, Gülnur Emingil","doi":"10.1111/odi.15310","DOIUrl":"10.1111/odi.15310","url":null,"abstract":"Objectives: Transgender individuals continue to face discrimination, particularly in accessing oral healthcare. This study aimed to evaluate dentists' attitudes toward transgender people and their knowledge of gender-affirming care.Materials and methods: A questionnaire assessing demographic data, clinical approaches, and knowledge of gender-affirming care was distributed via social media, professional chambers, and associations. Descriptive statistics were analyzed using SPSS, with Chi-square and Fisher exact tests, alongside logistic regression for appropriate questions.Results: A total of 403 dentists participated, with 8% reporting professional prejudices against transgender individuals. Dentists who associated transgender patients with increased clinical infection rates were statistically more likely to hold prejudices (p < 0.05). Additionally, 60.2% expressed interest in training to enhance communication with transgender patients. Female dentists were significantly more likely to be open to such training (p < 0.05).Conclusion: The findings highlight a strong desire among dentists for training to improve communication with transgender patients, along with a lack of knowledge about key topics such as gender-affirming, endogenous hormones, and their oral health implications. This underscores the need for targeted educational initiatives in the dental community.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2652-2660"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review. 口腔潜在恶性疾病的靶向治疗：系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-06 DOI: 10.1111/odi.15307

Lauren Frenzel Schuch, Fábio Muradás Girardi, Laura Borges Kirschnick, Aline Lauda Freitas Chaves, Luiz Paulo Kowalski, Ronell Bologna-Molina, William Nassib William Junior, Manoela Domingues Martins, Alan Roger Santos-Silva

{"title":"Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review.","authors":"Lauren Frenzel Schuch, Fábio Muradás Girardi, Laura Borges Kirschnick, Aline Lauda Freitas Chaves, Luiz Paulo Kowalski, Ronell Bologna-Molina, William Nassib William Junior, Manoela Domingues Martins, Alan Roger Santos-Silva","doi":"10.1111/odi.15307","DOIUrl":"10.1111/odi.15307","url":null,"abstract":"Objective: This study aimed to integrate the available data published in the literature to identify and elucidate the impact of targeted therapy for oral potentially malignant disorders (OPMDs).Material and methods: This systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. An electronic search across five databases with no publication date restriction was conducted in January 2023 and subsequently updated in January 2024. Eligibility criteria included studies focusing on targeted therapies. Interventions that either did not align with the specific definition of targeted therapy or failed to meet the criteria for precision-based treatment approaches were excluded from this review.Results: Six clinical trials were identified, all conducted in the United States. The sample size ranged from 12 to 150 subjects. Celecoxib, erlotinib, cetuximab, metformin, and nivolumab were employed as targeted systemic therapies at varying doses. Some patients experienced disease progression with no statistically significant differences in histological improvement rates or size increases. Certain studies reported treatment-related toxicity.Conclusion: The findings of this review do not support the use of targeted therapy in managing OPMDs, highlighting the need for additional clinical trials to further evaluate their efficacy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2394-2403"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rb3 Inhibits Oxidative Stress and Alleviates Experimental Periodontitis in Rats. 人参皂苷Rb3抑制氧化应激，减轻实验性牙周炎。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI: 10.1111/odi.15318

Xin Meng, Huijuan Qu, Xueying Zhang, Honghai Ji, Minmin Sun

{"title":"Ginsenoside Rb3 Inhibits Oxidative Stress and Alleviates Experimental Periodontitis in Rats.","authors":"Xin Meng, Huijuan Qu, Xueying Zhang, Honghai Ji, Minmin Sun","doi":"10.1111/odi.15318","DOIUrl":"10.1111/odi.15318","url":null,"abstract":"Objective: This study investigated the anti-inflammatory and antioxidative effects of ginsenoside Rb3 on experimental periodontitis.Methods: Experimental periodontitis was established by ligating the maxillary first molars. After 21 days of Rb3 treatment, rats were sacrificed for micro-CT and H&E staining analysis and serum assay. qPCR detected the expression of inflammatory genes. IF detected MAPKs pathway activation in periodontal tissues. The effects were determined using LPS-induced RAW264.7 cells. Gene expression levels were determined by qPCR. Intracellular ROS generation was detected by DCFH-DA staining and flow cytometry. WB detected the activation of signaling pathways.Results: Rb3 inhibited oxidative stress in experimental periodontitis, showing reduced gingivitis and alveolar bone resorption on H&E staining and micro-CT, and reduced iNOS mRNA in rats. Colorimetric results showed that Rb3 increased serum SOD and GSH-Px activities and decreased MDA levels in rats. IF analysis showed that Rb3 inhibited P38, ERK, and JNK activation. Rb3 pretreatment significantly decreased iNOS and IL-6 mRNA expression and ROS in Raw264.7 cells. WB analysis demonstrated that Rb3 blocked the activation of P38 and ERK.Conclusion: Rb3 inhibits the level of oxidative stress and attenuates gingivitis and alveolar bone resorption in rats via the MAPKs signaling pathway.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2540-2550"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraparotid Facial Nerve Schwannoma: A Comprehensive Review of 70 Cases at One Single Institution. 腮腺内面神经鞘瘤：对同一医院70例病例的综合分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI: 10.1111/odi.15323

Lingli Huang, Wei Xu, Wenya Zhu, Hao Lu, Shengwen Liu, Wenjun Yang, Wanlin Xu

{"title":"Intraparotid Facial Nerve Schwannoma: A Comprehensive Review of 70 Cases at One Single Institution.","authors":"Lingli Huang, Wei Xu, Wenya Zhu, Hao Lu, Shengwen Liu, Wenjun Yang, Wanlin Xu","doi":"10.1111/odi.15323","DOIUrl":"10.1111/odi.15323","url":null,"abstract":"Objective: The current study aimed to analyze the clinical characteristics, diagnosis, and surgical outcomes of intraparotid facial nerve schwannoma (IPFNS) and propose a more definitive therapeutic algorithm for IPFNS.Methods: Between January 2018 and December 2023, all the cases of IPFNS at our single institution were retrospectively reviewed.Results: In total, 70 patients were included in this study. Among them, 23 (32.3%) were men and 47 (67.7%) were women. The patients commonly presented with a painless parotid mass, and three patients complained of facial paralysis. Magnetic resonance imaging (MRI) had the highest diagnostic efficacy (37.1%) among all the evaluation techniques used. Marchioni's classification and surgical method were significantly associated with postoperative facial function. In terms of surgical interventions, stripping surgery was suitable for type A tumors, while for types B, C, and D tumors, intracapsular enucleation with a microscope was recommended to decrease the influence of the procedure on facial nerve function.Conclusions: IPFNS is a rare disease, whose diagnosis and management remain challenging. MRI is the preferred preoperative diagnostic method. Preoperative facial nerve function, tumor location, and patients' preferences are key factors in the decision-making process of IPFNS treatment.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2487-2495"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Overexpression of LAG3, TIM3, and A2aR in Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma". 修正“LAG3、TIM3和A2aR在腺样囊性癌和粘液表皮样癌中的过表达”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-22 DOI: 10.1111/odi.15309

引用次数: 0