Oral diseases最新文献

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Oral Microbiome Alterations in Oral Lichen Planus Across Saliva, Dental Plaque, and Tongue Coating. 口腔扁平苔藓在唾液、牙菌斑和舌苔中的微生物组改变。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-24 DOI: 10.1111/odi.70480
Atsumu Kouketsu, Toru Tamahara, Satoshi Fukase, Tatsuru Saito, Akiko Ito, Pawat Sripodok, Yutaro Higashi, Tsuyoshi Kurobane, Tomonari Kajita, Masaaki Miyakoshi, Masahiro Iikubo, Kensuke Yamauchi, Kazuki Kumada, Bin Li, Muneaki Shimada, Miguel Reis Ferreira, David Moyes, Ritsuko Shimizu, Tsuyoshi Sugiura
{"title":"Oral Microbiome Alterations in Oral Lichen Planus Across Saliva, Dental Plaque, and Tongue Coating.","authors":"Atsumu Kouketsu, Toru Tamahara, Satoshi Fukase, Tatsuru Saito, Akiko Ito, Pawat Sripodok, Yutaro Higashi, Tsuyoshi Kurobane, Tomonari Kajita, Masaaki Miyakoshi, Masahiro Iikubo, Kensuke Yamauchi, Kazuki Kumada, Bin Li, Muneaki Shimada, Miguel Reis Ferreira, David Moyes, Ritsuko Shimizu, Tsuyoshi Sugiura","doi":"10.1111/odi.70480","DOIUrl":"https://doi.org/10.1111/odi.70480","url":null,"abstract":"<p><strong>Objective: </strong>To characterise oral lichen planus-associated oral microbiome alterations separately in saliva, supragingival dental plaque, and tongue coating.</p><p><strong>Methods: </strong>In this cross-sectional study, samples from patients with oral lichen planus and healthy controls were analysed using bacterial amplicon sequencing. Microbial diversity, taxonomic composition, and genus-level differential abundance were compared within each sample type.</p><p><strong>Results: </strong>Analyses included 47 control and 35 oral lichen planus saliva samples, 10 and 30 dental plaque samples, and 47 and 32 tongue coating samples, respectively. Significant alpha-diversity differences were observed for all four indices in saliva, three in tongue coating, and one in dental plaque. Beta-diversity differed between groups within all three sample types. Unweighted phylogenetic and presence-absence distances most consistently detected group differences, whereas abundance-weighted phylogenetic distances were not significant after correction. Unweighted phylogenetic differences remained significant after adjustment for Plaque Control Record. Descriptive taxonomic and differential-abundance patterns varied among sample types, with saliva yielding the largest number of significant taxa.</p><p><strong>Conclusion: </strong>Oral lichen planus was associated with microbiome alterations in all three sample types, mainly reflecting differences in microbial community membership. These sample types may provide complementary information for characterising oral lichen planus-associated dysbiosis.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenomics in Dentistry: From CYP-Mediated Drug Response to Precision Prescribing in Oral Healthcare. 牙科药物基因组学:从cypp介导的药物反应到口腔保健中的精确处方。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-21 DOI: 10.1111/odi.70468
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci
{"title":"Pharmacogenomics in Dentistry: From CYP-Mediated Drug Response to Precision Prescribing in Oral Healthcare.","authors":"Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci","doi":"10.1111/odi.70468","DOIUrl":"https://doi.org/10.1111/odi.70468","url":null,"abstract":"<p><strong>Objective: </strong>This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings.</p><p><strong>Materials and methods: </strong>A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January 2000 to March 2026. The search focused on gene-drug interactions involving medications commonly prescribed or clinically relevant in dental care, including analgesics, NSAIDs, antiplatelet agents, anticoagulants, antibiotics and local anaesthetics. Relevant guidelines, landmark studies and key reviews were also considered.</p><p><strong>Results: </strong>Most genomic findings related to oral diseases provide biological insights but limited routine clinical utility. Conversely, selected pharmacogenomic determinants show clearer applicability. CYP2D6 variability is the most robust example, influencing codeine and tramadol efficacy and toxicity. CYP2C9 variants may affect NSAID safety, while CYP2C19, VKORC1 and CYP2C9 are relevant in patients receiving antiplatelet or anticoagulant therapy. Other determinants, including SCN9A, CYP3A4/5 and ABCB1, remain investigational. Drug-drug interactions and phenoconversion further influence real-world responses.</p><p><strong>Conclusion: </strong>Pharmacogenomics currently represents the most actionable area of dental genomics. Current evidence supports selective, scenario-based integration, particularly in pain management, adverse drug reactions, polypharmacy and medically complex patients.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of Malignant Transformation in Recurrent Versus Nonrecurrent Oral Potentially Malignant Disorders: A Retrospective Study. 复发性与非复发性口腔潜在恶性疾病的恶性转化时机:一项回顾性研究。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70477
Shih-Wei Yang, Yi-Chan Lee, Yun-Shien Lee
{"title":"Timing of Malignant Transformation in Recurrent Versus Nonrecurrent Oral Potentially Malignant Disorders: A Retrospective Study.","authors":"Shih-Wei Yang, Yi-Chan Lee, Yun-Shien Lee","doi":"10.1111/odi.70477","DOIUrl":"https://doi.org/10.1111/odi.70477","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative recurrence of oral potentially malignant disorders (OPMDs) is common. This study investigated whether the timing of malignant transformation differs between recurrent and nonrecurrent lesions.</p><p><strong>Methods: </strong>This retrospective observational study included patients who underwent carbon dioxide laser excision for OPMDs and later developed oral squamous cell carcinoma between July 2002 and July 2024. Clinicopathological characteristics and transformation intervals were compared between recurrent and nonrecurrent lesions.</p><p><strong>Results: </strong>Among 898 treated patients, 38 (4.2%) developed malignant transformation. Of these, 28 (73.7%) had no postoperative recurrence before malignant transformation, whereas 10 (26.3%) experienced recurrence. Although most malignant transformation cases occurred in nonrecurrent lesions, recurrent lesions had a significantly shorter transformation interval (p = 0.014). All recurrent lesions progressed to oral squamous cell carcinoma within 2.3 years, whereas nonrecurrent lesions exhibited a broader range of transformation intervals, extending from several weeks to more than 13 years. No significant differences were observed in other clinicopathological characteristics.</p><p><strong>Conclusions: </strong>Although most malignant transformation cases occurred in OPMDs without documented postoperative recurrence, recurrent OPMDs were associated with a significantly shorter transformation interval. These findings suggest that recurrent lesions may warrant closer clinical surveillance, while long-term surveillance remains important regardless of recurrence status.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation. 有/没有1型糖尿病和不同程度牙龈炎症的个体唾液Apelin水平和牙周表现
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70467
Demet Efe Yavaşoğlu, Andressa V B Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli
{"title":"Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation.","authors":"Demet Efe Yavaşoğlu, Andressa V B Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli","doi":"10.1111/odi.70467","DOIUrl":"10.1111/odi.70467","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque-induced gingival inflammation.</p><p><strong>Methods: </strong>Saliva samples were collected; and whole-mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy participants. Salivary apelin concentrations were determined using ELISA. Data were analysed statistically using the Shapiro-Wilk test for normality of distribution, the Mann-Whitney U test for intergroup differences, and Spearman's rank correlation analysis to assess correlations between clinical and biochemical parameters.</p><p><strong>Results: </strong>A total of 99 participants; including 59 individuals in the type 1 diabetes group and 40 in the systemically healthy were included. The two groups were similar in terms of age, gender distribution, and smoking status (p > 0.05). The salivary apelin concentration in the diabetic group (4647.13 ± 8584.45 pg/mL) was almost twice that in the systemically healthy group (2704.12 ± 3006.73 pg/mL) without statistically significant difference (0.114). Clinical periodontal measurements were similar between the two groups (p > 0.05). Neither gender nor smoking status had a significant effect on apelin levels (p > 0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, the observed trend toward higher salivary apelin levels in patients with type 1 diabetes may suggest a possible association that requires confirmation in larger cohorts.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Candidiasis in Patients With Oral Lichen Planus Receiving Topical Corticosteroids: A Retrospective Cohort Study. 接受局部皮质类固醇治疗的口腔扁平苔藓患者的口腔念珠菌病:一项回顾性队列研究。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70470
Alba Díaz-Rodríguez, Alejandro I Lorenzo-Pouso, Eva María Otero-Rey, Pilar Gándara-Vila, José Manuel Somoza-Martín, Mario Pérez-Sayáns, Andrés Blanco-Carrión
{"title":"Oral Candidiasis in Patients With Oral Lichen Planus Receiving Topical Corticosteroids: A Retrospective Cohort Study.","authors":"Alba Díaz-Rodríguez, Alejandro I Lorenzo-Pouso, Eva María Otero-Rey, Pilar Gándara-Vila, José Manuel Somoza-Martín, Mario Pérez-Sayáns, Andrés Blanco-Carrión","doi":"10.1111/odi.70470","DOIUrl":"https://doi.org/10.1111/odi.70470","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the incidence and predictors of oral candidiasis in patients with oral lichen planus (OLP) treated with topical corticosteroids.</p><p><strong>Methods: </strong>Retrospective cohort study of 312 adults with OLP followed for 487.5 person-years. The primary outcome was the first microbiologically confirmed episode of oral candidiasis. Adjusted incidence rate ratios (IRRs and rinses) were estimated using Poisson regression; Cox proportional hazards models were used for sensitivity analysis.</p><p><strong>Results: </strong>Oral candidiasis occurred in 78 patients (25.0%; incidence rate 0.160 per person-year), with a median onset of 4 months. Risk peaked within the first 2 months and declined thereafter (IRR = 0.33 for 4-8 months; IRR = 0.08 for > 8 months). Higher disease severity predicted infection (highest vs. lowest quartile: IRR = 1.61; 95% CI: 1.02-2.54). Poor oral hygiene (IRR = 1.88; 95% CI: 1.13-3.13) and removable partial dentures (IRR = 1.68; 95% CI: 1.07-2.63) were independently associated. Clobetasol propionate showed a higher risk than triamcinolone acetonide (IRR = 1.48; 95% CI: 0.96-2.28); these associations remained consistent in sensitivity analysis. No associations were observed for age, sex, alcohol use or xerostomia.</p><p><strong>Conclusions: </strong>Oral candidiasis is common in corticosteroid-treated OLP. Risk is driven by disease severity and modifiable local factors, supporting targeted prevention and monitoring.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cultural Practices and Oral Cancer Risk in South America: An Evidence- and Experience-Based Position Paper. 南美洲的文化习俗和口腔癌风险:基于证据和经验的立场文件。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70466
Mariana Villarroel-Dorrego, Gloria Jeanethe Álvarez Gómez, Ignacio Molina-Ávila, René Panico, Eduardo Piemonte, José Alcides Almeida de Arruda, Leonardo Amaral Dos Reis, Saman Warnakulasuriya, Bruno Augusto Benevenuto de Andrade, Ronell Bologna-Molina, Gerardo Gilligan
{"title":"Cultural Practices and Oral Cancer Risk in South America: An Evidence- and Experience-Based Position Paper.","authors":"Mariana Villarroel-Dorrego, Gloria Jeanethe Álvarez Gómez, Ignacio Molina-Ávila, René Panico, Eduardo Piemonte, José Alcides Almeida de Arruda, Leonardo Amaral Dos Reis, Saman Warnakulasuriya, Bruno Augusto Benevenuto de Andrade, Ronell Bologna-Molina, Gerardo Gilligan","doi":"10.1111/odi.70466","DOIUrl":"https://doi.org/10.1111/odi.70466","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity squamous cell carcinoma (OSCC) remains a major public health challenge worldwide. In South America, its epidemiology is influenced by culturally embedded practices that remain underrepresented in the international literature.</p><p><strong>Aims: </strong>To critically examine region-specific exposures that may contribute to oral carcinogenesis and to identify major knowledge gaps relevant to OSCC prevention and early detection in South America.</p><p><strong>Materials and methods: </strong>This evidence-informed position paper was developed through consensus among specialists from South American referral centers and a structured appraisal of the available literature, focusing on chimó use, coca leaf chewing, reverse smoking, hot mate consumption, and charcoal-grilled meat intake.</p><p><strong>Results: </strong>Current evidence suggests that these practices involve biologically plausible mechanisms, including thermal injury, chronic mechanical irritation, exposure to potentially carcinogenic chemical compounds, and persistent mucosal inflammation, that may promote carcinogenesis.</p><p><strong>Discussion: </strong>The strength of the available evidence varies considerably across exposures, and several associations remain hypothesis-generating and require further epidemiological, mechanistic, and molecular validation.</p><p><strong>Conclusion: </strong>This position paper identifies major knowledge gaps and proposes a regional research agenda aimed at improving risk assessment, prevention strategies, and the early detection of OSCC in South America.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Lichenoid Lesions in Patients With Dyskeratosis Congenita: A Retrospective Case Series. 先天性角化不良患者的口腔苔藓样病变:回顾性病例系列。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70465
Yehuda Zadik, Ori Finfter, Tevel Amiel, Amina Massarwa, Refael Cohen, Jawad Abu Tair, Anna Novikov, Polina Stepensky, Irina Zaidman, Ehud Even-Or
{"title":"Oral Lichenoid Lesions in Patients With Dyskeratosis Congenita: A Retrospective Case Series.","authors":"Yehuda Zadik, Ori Finfter, Tevel Amiel, Amina Massarwa, Refael Cohen, Jawad Abu Tair, Anna Novikov, Polina Stepensky, Irina Zaidman, Ehud Even-Or","doi":"10.1111/odi.70465","DOIUrl":"https://doi.org/10.1111/odi.70465","url":null,"abstract":"<p><strong>Background: </strong>Dyskeratosis congenita (DKC) is a rare inherited multisystem disorder primarily affecting the mucocutaneous and hematopoietic systems. Classically, it presents with the ectodermal triad of reticulate skin pigmentation, nail dystrophy, and oral leukoplakia. This retrospective case series aimed to characterize the oral manifestations in patients followed at a tertiary oral medicine clinic.</p><p><strong>Methods: </strong>Clinical data of patients with DKC followed at the Hadassah Oral Medicine Clinic for Hemato-Oncologic Patients between 2020 and 2025 were retrospectively reviewed to characterize hematologic, somatic, and oral manifestations.</p><p><strong>Results: </strong>Six DKC patients were included. Five patients underwent HCT, none of whom developed acute or chronic graft-versus-host disease. Oral lichenoid lesions, manifesting as reticular (striated), plaque-like, or erosive-ulcerative patterns, were observed in two patients before and in four patients following hematopoietic cell transplantation (HCT). Three patients presented with plaque-like hyperkeratotic lesions ('leukoplakia'). One patient developed squamous cell carcinoma of the dorsal tongue at 25 years of age.</p><p><strong>Conclusions: </strong>The oral lesions observed in DKC included not only leukoplakia but also lichenoid and erosive or ulcerative lesions, suggesting a broader clinical spectrum of oral involvement. Further studies are needed to clarify genotype-phenotype correlations and to better define the relationship between oral manifestations and subsequent oral carcinoma development.</p><p><strong>Main finding: </strong>Oral manifestations in dyskeratosis congenita are diverse and often extend beyond the traditionally described 'leukoplakia', frequently exhibiting lichenoid or erosive lesions.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggressive Destructive Maxillary Mass: A Non-Expected Diagnosis. 侵略性破坏性上颌肿块:一个出乎意料的诊断。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70456
Gerardo Gilligan, René Panico, Eduardo Piemonte, Baltazar Daniel, Malena Gervasoni, Federico Garola, María Luisa Paparella, Bruno Benevenuto de Andrade, Benjamin Martínez
{"title":"Aggressive Destructive Maxillary Mass: A Non-Expected Diagnosis.","authors":"Gerardo Gilligan, René Panico, Eduardo Piemonte, Baltazar Daniel, Malena Gervasoni, Federico Garola, María Luisa Paparella, Bruno Benevenuto de Andrade, Benjamin Martínez","doi":"10.1111/odi.70456","DOIUrl":"https://doi.org/10.1111/odi.70456","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Health-Related Quality of Life and Depressive Symptoms in Oral Mucosal Diseases: A Cross-Sectional Observational Pilot Study. 口腔黏膜疾病患者口腔健康相关生活质量和抑郁症状:一项横断面观察性初步研究
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-20 DOI: 10.1111/odi.70475
Domenico Cutecchia, Tommaso Marvulli, Vittorio Dibello, Alberta Lucchese, Massimo Petruzzi, Domenico De Falco
{"title":"Oral Health-Related Quality of Life and Depressive Symptoms in Oral Mucosal Diseases: A Cross-Sectional Observational Pilot Study.","authors":"Domenico Cutecchia, Tommaso Marvulli, Vittorio Dibello, Alberta Lucchese, Massimo Petruzzi, Domenico De Falco","doi":"10.1111/odi.70475","DOIUrl":"https://doi.org/10.1111/odi.70475","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association between oral mucosal diseases, oral health-related quality of life (OHRQoL), and depressive symptoms, and to explore differences across categories.</p><p><strong>Materials and methods: </strong>In this cross-sectional observational pilot study, consecutive outpatients with oral mucosal disease were enrolled at the Dental Clinic of the Policlinico of Bari over one year. OHRQoL and depressive symptoms were assessed using the Oral Health Impact Profile-14 (OHIP-14) and Patient Health Questionnaire-9 (PHQ-9). Participants were classified into four diagnostic groups: idiopathic/chronic orofacial pain syndromes, autoimmune diseases, oral potentially malignant disorders (OPMDs), and reactive-inflammatory/traumatic lesions. Nonparametric tests and a multivariable negative binomial regression model were applied.</p><p><strong>Results: </strong>Sixty-six patients were included, and OHIP-14 and PHQ-9 scores showed a moderate positive correlation (Spearman's p = 0.41; p < 0.01). Kruskal-Wallis testing suggested a difference in OHIP-14 scores across groups (p = 0.03), with the greatest exploratory post hoc difference between chronic orofacial pain syndromes and OPMDs (adjusted p = 0.03), whereas PHQ-9 scores did not differ across groups (p = 0.93).</p><p><strong>Conclusions: </strong>Diagnostic category appeared to influence OHRQoL, but not depressive symptoms; however, findings should be considered exploratory.</p><p><strong>Clinical significance: </strong>These exploratory findings suggest that OHRQoL assessment may complement oral mucosal disease evaluation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Slow-Growing Hard Palate Tumor: Clinical Challenge. 生长缓慢的硬腭肿瘤:临床挑战。
IF 3.1 3区 医学
Oral diseases Pub Date : 2026-08-18 DOI: 10.1111/odi.70452
Isidora Mujica Valenzuela, Gabriel Andrade Cabrera, Agustín Márquez Zambrano, María José Garib Sande, Sergio González Providell, María Inés González Agurto
{"title":"A Slow-Growing Hard Palate Tumor: Clinical Challenge.","authors":"Isidora Mujica Valenzuela, Gabriel Andrade Cabrera, Agustín Márquez Zambrano, María José Garib Sande, Sergio González Providell, María Inés González Agurto","doi":"10.1111/odi.70452","DOIUrl":"https://doi.org/10.1111/odi.70452","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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