Oral diseases最新文献_第9页

A real-life experience of long-term use of pilocarpine in irradiated head and neck cancer patients. 头颈部癌症患者长期使用皮洛卡平的真实体验。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-26 DOI: 10.1111/odi.14905

Rungarun Kittichet, Imjai Chitapanarux, Kittikun Kittidachanan, Patumrat Sripan

{"title":"A real-life experience of long-term use of pilocarpine in irradiated head and neck cancer patients.","authors":"Rungarun Kittichet, Imjai Chitapanarux, Kittikun Kittidachanan, Patumrat Sripan","doi":"10.1111/odi.14905","DOIUrl":"10.1111/odi.14905","url":null,"abstract":"Aims: To assess long-term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation-induced xerostomia (RIX).Methods: Retrospective observational study was conducted. Eligibility criteria included irradiated HNC patients who received pilocarpine at least 12 weeks either for prevention (group A) or for treatment (group B) of RIX. We collected the documented Late Effect Normal Tissue Task Force-Subjective, Objective, Management, Analytics subjective/objective grades of RIX before (only group B) and the latest visit for pilocarpine prescription, dosage, side effects, duration of treatment, and the cause of discontinuation.Results: Between December 2007 and June 2022, 182 patients were enrolled including 95 patients (52%) in group A and 87 patients (48%) in group B. Group A patients reported grades 1, 2, 3, and 4 objective RIX in 0%, 7%, 93%, and 0%. Grade 1, 2, and 3 subjective RIX were 57%, 28%, and 15%. All patients in group B had grade 3 both objective/subjective RIX. The overall improvement of objective/subjective RIX was found in 40%/83%. Discontinuation was found in 51% of patients due to tolerable symptoms or deterioration of the patient's status.Conclusions: Based on this retrospective analysis, long-term use of pilocarpine in irradiated HNC appears feasible for both prevention and treatment of RIX.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short and long effects of the COVID-19 context on oral health-related quality of life of adolescents. COVID-19 对青少年口腔健康相关生活质量的短期和长期影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-29 DOI: 10.1111/odi.14885

Marina Blanco Pohl, Thais Gioda Noronha-Ramos, Jessica Klöckner Knorst, Marcia Farias Pereira Lito, Gabriela de Araujo, Bruno Emmanuelli, Thiago Machado Ardenghi, Fernanda Tomazoni

{"title":"Short and long effects of the COVID-19 context on oral health-related quality of life of adolescents.","authors":"Marina Blanco Pohl, Thais Gioda Noronha-Ramos, Jessica Klöckner Knorst, Marcia Farias Pereira Lito, Gabriela de Araujo, Bruno Emmanuelli, Thiago Machado Ardenghi, Fernanda Tomazoni","doi":"10.1111/odi.14885","DOIUrl":"10.1111/odi.14885","url":null,"abstract":"Aim: To assess the immediate and late effects of the COVID-19 pandemic on the oral health-related quality of life (OHRQoL) of adolescents.Design: This is a longitudinal study performed with adolescents (11-15 years old) from Southern Brazil who were evaluated before the COVID-19 outbreak, and 3 (T2) and 15 (T3) months after the beginning of the pandemic. OHRQoL was assessed using the CPQ11-14. Sociodemographic and clinical variables were also collected. Changes in OHRQoL before, 3 and 15 months after the start of the pandemic were analyzed through multilevel Poisson regression models for repeated measures.Results: A total of 290 adolescents were evaluated at T1, 207 were re-evaluated at T2, and 204 at T3. Overall CPQ11-14 scores over follow-ups were 11.0 (SD 8.0) at T1, 8.3 (SD 7.8) and 12.8 (SD 8.8) at T3. Compared to T1, adolescents presented 29% lower overall CPQ11-14 scores (IRR 0.71 95% CI 0.66-0.75) at T2, and 11% higher scores at T3 (IRR 1.11 95% CI 1.05-1 0.17), especially for the emotional and social well-being domains.Conclusion: COVID-19 pandemic impacted the adolescents' OHRQoL differently over time, indicating a reduction in impacts immediately after the beginning and worsening over long term exposure to this scenario.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change and oral health: Assessing the impacts and developing strategies for adaptation. 气候变化与口腔健康：评估影响并制定适应战略。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1111/odi.14922

Delfin Lovelina Francis, Saravanan Sampoornam Pape Reddy, Anitha Logaranjani, Sukhbir Singh Chopra

引用次数: 0

Oral submucosal fibrosis: An updated molecular mechanism on pathogenesis and treatment modalities. 口腔黏膜下纤维化：关于发病机制和治疗方法的最新分子机制。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14901

Vadivel Jayanth Kumar, Devaraj Ezhilarasan, Deepak Nallasamy Veeraiyan

引用次数: 0

Cross-cultural adaptation of the Thai Xerostomia Inventory and Summated Xerostomia Inventory. 泰国口臭量表》和《口臭总和量表》的跨文化改编。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-11 DOI: 10.1111/odi.14891

Chotima Lapnimitanun, Paswach Wiriyakijja, Oranart Matangkasombut, Orapin Komin

{"title":"Cross-cultural adaptation of the Thai Xerostomia Inventory and Summated Xerostomia Inventory.","authors":"Chotima Lapnimitanun, Paswach Wiriyakijja, Oranart Matangkasombut, Orapin Komin","doi":"10.1111/odi.14891","DOIUrl":"10.1111/odi.14891","url":null,"abstract":"Objective: To cross-culturally adapt and validate the Thai version of the Xerostomia Inventory (XI) and Summated Xerostomia Inventory (SXI) for subjective evaluation of oral dryness in Thai middle-aged and older adults.Methods: The original English versions of the XI and SXI were cross-culturally translated into Thai. Content validity was examined by the expert panel and 30 pilot subjects. The XI/SXI-Thai were then administered to 200 Thai adults (aged 50 years or older) for further assessment of psychometric properties. The standard question, the Bother Index, and the Xerostomia Questionnaire were used as comparator instruments for the evaluation of criterion and construct validity, respectively. Internal consistency reliability was assessed using Cronbach's alpha.Results: The final XI/SXI-Thai were found to have good content validity. Both scales were able to distinguish between xerostomia and non-xerostomia groups. We observed moderate to strong correlation between the XI/SXI-Thai and other comparator instruments, reflecting good criterion and construct validity. Cronbach's alpha values were 0.875 and 0.847 for the XI-Thai and SXI-Thai, respectively.Conclusions: The XI-Thai and SXI-Thai were found to be valid, reliable, and easily administrable instruments for xerostomia assessment in Thai middle-aged and older individuals in both clinical and research settings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflecting the human lip in vitro: Cleft lip skin and mucosa keratinocytes keep their identities. 体外反映人类嘴唇：唇裂皮肤和粘膜角质细胞保持其特性

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-04 DOI: 10.1111/odi.14844

Silvia Rihs, Ludovica Parisi, Anic Lauener, Farah Mansour, Isabelle Schnyder, Gabriela M Dekany, Giorgio C La Scala, Christos Katsaros, Martin Degen

{"title":"Reflecting the human lip in vitro: Cleft lip skin and mucosa keratinocytes keep their identities.","authors":"Silvia Rihs, Ludovica Parisi, Anic Lauener, Farah Mansour, Isabelle Schnyder, Gabriela M Dekany, Giorgio C La Scala, Christos Katsaros, Martin Degen","doi":"10.1111/odi.14844","DOIUrl":"10.1111/odi.14844","url":null,"abstract":"Objectives: Cell models have shown great promise as tools for research, potentially providing intriguing alternatives to animal models. However, the original tissue characteristics must be maintained in culture, a fact that is often assumed, but seldom assessed. We aimed to follow the retention of the original tissue identities of cleft lip-derived skin and mucosa keratinocytes in vitro.Methods: Cleft lip-derived keratinocytes were isolated from discarded tissue along the cleft margins during cheiloplasty. Cell identities were assessed by immunohistochemistry and quantitative real-time PCR for tissue-specific markers and compared with native lip tissue. Moreover, keratinocytes were regularly analyzed for the retention of the original tissue characteristics by the aforementioned methods as well as by differentiation assays.Results: The various anatomical zones of the human lip could be distinguished using a panel of differentiation and functional-based markers. Using these markers, retention of the original tissue identities could be followed and confirmed in the corresponding primary keratinocytes in culture.Conclusions: Our findings promote patient-derived cells retaining their original identities as astonishing and clinically relevant in vitro tools. Such cells allow a better molecular understanding of various lip-associated pathologies as well as their modeling in vitro, including but not restricted to orofacial clefts.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium fluoride-induced autophagy of ameloblast-like cells via the p-ULk1/ATG13/LC3B pathway in vitro. 氟化钠通过p-ULk1/ATG13/LC3B途径诱导体外羊膜样细胞自噬

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-06 DOI: 10.1111/odi.14884

S Yang, D Song, R Wang, M Liu, T Tan, Y Wang, Q Xie, L Wang

{"title":"Sodium fluoride-induced autophagy of ameloblast-like cells via the p-ULk1/ATG13/LC3B pathway in vitro.","authors":"S Yang, D Song, R Wang, M Liu, T Tan, Y Wang, Q Xie, L Wang","doi":"10.1111/odi.14884","DOIUrl":"10.1111/odi.14884","url":null,"abstract":"Objective: To investigate the effects of sodium fluoride on the ameloblast and reveal the mechanism of dental fluorosis.Materials and methods: Mouse ameloblast-like cell line (ALC) cells were treated with various concentrations of NaF, and subjected to Incucyte, fluorescence immunoassay, transmission electron microscopy, reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blot for autophagy examination, alkaline phosphatase and alizarin red staining for mineralization after osteogenic induction.Results: NaF exerts a dose-dependent inhibitory effect on ALC cell growth. TEM and fluorescence immunoassay showed that 1.5 mM or higher concentrations of NaF could induce a fusion of lysosome and mitochondria, finally increasing the number of autophagosome. RT-qPCR and western blot showed that the upregulation of autophagy related gene 13 (ATG13), downregulation of phosphorylated Unc-51-like kinase 1 (p-ULK1) were found in NaF-induced autophagy of ALC cells. The knockdown of ATG13 could rescue it as well as the expression of p-ULK1 and LC3B. Besides, alizarin red staining showed that fluoride under these concentrations could promote the mineralization of ALC.Conclusions: The data show that fluoride in higher concentration can induce autophagy via the p-ULk1/ATG13/LC3B pathway of ALCs than lower ones promote mineralization in vitro, which provides insight into the function of NaF in the autophagy and mineralization of ameloblast.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis. 预防口腔黏膜炎的外用药物疗效：系统综述和网络荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI: 10.1111/odi.15046

Martina Coppini, Vito Carlo Alberto Caponio, Rodolfo Mauceri, Maria Eleonora Bizzoca, Luigi Laino, Alejandro I Lorenzo-Pouso, Diana Russo, Giuseppe Troiano, Fábio França Vieira E Silva, Lorenzo Lo Muzio, Giuseppina Campisi

{"title":"Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis.","authors":"Martina Coppini, Vito Carlo Alberto Caponio, Rodolfo Mauceri, Maria Eleonora Bizzoca, Luigi Laino, Alejandro I Lorenzo-Pouso, Diana Russo, Giuseppe Troiano, Fábio França Vieira E Silva, Lorenzo Lo Muzio, Giuseppina Campisi","doi":"10.1111/odi.15046","DOIUrl":"10.1111/odi.15046","url":null,"abstract":"Background: Oral mucositis (OM) is considered one of the most common side effects of patients undergoing cancer therapy. OM prevention plays a crucial role in the effectiveness of cancer treatment and the patient's quality of life. Different preventive treatments have been proposed in clinical trials, however with inconclusive results.Materials and methods: A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: in cancer patients, do specific topical agents compared to standard treatments or placebo reduce the onset and severity of oral mucositis? The risk of bias was assessed, and a network meta-analysis was conducted.Results: Of 2913 results, 30 randomized clinical trials were considered suitable for inclusion. A total of 2564 patients were analyzed, of which 1284 belonged to the test group and 1280 belonged to the control group. Natural products were the most used, followed mainly by antimicrobial agents, coating agents, and basic oral care measures. Topical sucralfate resulted in the most powerful intervention for the OM prevention (OR = 0.04, 95%C.I. = 0.01-0.25, p-value = 0.001).Conclusion: Due to its cytoprotective action, low cost, ease of administration, and safety, sucralfate could become a potential ally to prevent the onset of OM during cancer therapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary annular lesion on the ventral tongue. 舌头腹侧有孤立的环状病变。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-05-12 DOI: 10.1111/odi.14946

Maxwell E Perelgut, Allison M Lee, Ana Luiza O C Roza, Joshua C Allen, John M Wright

引用次数: 0

Fibrocyte: A missing piece in the pathogenesis of fibrous epulis. 纤维细胞：纤维外皮炎发病机制中缺失的一环。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2023-12-26 DOI: 10.1111/odi.14847

Yi-Fei Zhu, Mei-Chen Wan, Peng Gao, Min-Juan Shen, Yi-Na Zhu, Jia-Xin Hao, Wei-Cheng Lu, Chen-Yu Wang, Franklin Tay, Hermann Ehrlich, Li-Na Niu, Kai Jiao

{"title":"Fibrocyte: A missing piece in the pathogenesis of fibrous epulis.","authors":"Yi-Fei Zhu, Mei-Chen Wan, Peng Gao, Min-Juan Shen, Yi-Na Zhu, Jia-Xin Hao, Wei-Cheng Lu, Chen-Yu Wang, Franklin Tay, Hermann Ehrlich, Li-Na Niu, Kai Jiao","doi":"10.1111/odi.14847","DOIUrl":"10.1111/odi.14847","url":null,"abstract":"Objectives: To explore the role of fibrocytes in the recurrence and calcification of fibrous epulides.Methods: Different subtypes of fibrous epulides and normal gingival tissue specimens were first collected for histological and immunofluorescence analyses to see if fibrocytes were present and whether they differentiated into myofibroblasts and osteoblasts upon stimulated by transforming growth factor-β1 (TGF-β1). Electron microscopy and elemental analysis were used to characterize the extracellular microenvironment in different subtypes of fibrous epulides. Human peripheral blood mononuclear cells (PBMCs) were subsequently isolated from in vitro models to mimic the microenvironment in fibrous epulides to identify whether TGF-β1 as well as the calcium and phosphorus ion concentration in the extracellular matrix (ECM) of a fibrous epulis trigger fibrocyte differentiation.Results: Fibrous epulides contain fibrocytes that accumulate in the local inflammatory environment and have the ability to differentiate into myofibroblasts or osteoblasts. TGF-β1 promotes fibrocytes differentiation into myofibroblasts in a concentration-dependent manner, while TGF-β1 stimulates the fibrocytes to differentiate into osteoblasts when combined with a high calcium and phosphorus environment.Conclusions: Our study revealed fibrocytes play an important role in the fibrogenesis and osteogenesis in fibrous epulis, and might serve as a therapeutic target for the inhibition of recurrence of fibrous epulides.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0