Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-06 DOI:10.1111/odi.15307

Lauren Frenzel Schuch, Fábio Muradás Girardi, Laura Borges Kirschnick, Aline Lauda Freitas Chaves, Luiz Paulo Kowalski, Ronell Bologna-Molina, William Nassib William Junior, Manoela Domingues Martins, Alan Roger Santos-Silva

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引用次数: 0

Abstract

Objective: This study aimed to integrate the available data published in the literature to identify and elucidate the impact of targeted therapy for oral potentially malignant disorders (OPMDs).

Material and methods: This systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. An electronic search across five databases with no publication date restriction was conducted in January 2023 and subsequently updated in January 2024. Eligibility criteria included studies focusing on targeted therapies. Interventions that either did not align with the specific definition of targeted therapy or failed to meet the criteria for precision-based treatment approaches were excluded from this review.

Results: Six clinical trials were identified, all conducted in the United States. The sample size ranged from 12 to 150 subjects. Celecoxib, erlotinib, cetuximab, metformin, and nivolumab were employed as targeted systemic therapies at varying doses. Some patients experienced disease progression with no statistically significant differences in histological improvement rates or size increases. Certain studies reported treatment-related toxicity.

Conclusion: The findings of this review do not support the use of targeted therapy in managing OPMDs, highlighting the need for additional clinical trials to further evaluate their efficacy.

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口腔潜在恶性疾病的靶向治疗：系统综述。

目的：本研究旨在整合已发表的文献数据，以确定和阐明靶向治疗对口腔潜在恶性疾病（OPMDs）的影响。材料和方法：本系统评价是根据系统评价和荟萃分析首选报告项目（PRISMA） 2020声明的指南进行的。在没有出版日期限制的情况下，于2023年1月对五个数据库进行了电子检索，随后于2024年1月进行了更新。入选标准包括针对靶向治疗的研究。不符合靶向治疗的具体定义或不符合精确治疗方法标准的干预措施被排除在本综述之外。结果：确定了6项临床试验，均在美国进行。样本量从12人到150人不等。塞来昔布、厄洛替尼、西妥昔单抗、二甲双胍和纳武单抗被用作不同剂量的靶向全身治疗。一些患者经历了疾病进展，在组织学改善率或大小增加方面没有统计学上的显著差异。某些研究报告了治疗相关的毒性。结论：本综述的结果不支持使用靶向治疗来管理opmd，强调需要更多的临床试验来进一步评估其疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.