Effects of Non-Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI:10.1111/odi.15340

Xiaoyuan Guan, Xian-E Wang, Yi Li, Jingling Xu, Xinran Xu, Lu He, Li Xu, Huanxin Meng, Ruifang Lu

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引用次数: 0

Abstract

Objective: To investigate the short-term effects of non-surgical periodontal treatment (NSPT) on clinical and hematological indices in stage III/IV grade C periodontitis patients.

Methods: A total of 121 systemically healthy patients with generalized stage III/IV, grade C periodontitis were enrolled. Clinical indices (plaque index, probing depth, bleeding index, attachment loss) and hematological biomarkers [white blood cell count (WBC), mean platelet volume (MPV), neutrophil count (NEUT), neutrophil percentage (NEUT%), lymphocyte percentage (LYM%)] were measured before and 6-8 weeks after NSPT. Patients were divided into younger (≤ 35 years) and elder (> 35 years) groups, further stratified by systemic antibiotics usage. Analyses were performed using chi-squared tests, paired t-tests, and Pearson's correlation.

Results: NSPT resulted in clinical indices improvement, as well as a reduction in WBC, NEUT, NEUT%, and an increase in MPV and LYM% in both groups. SRP-with-antibiotics subgroups showed more significant changes. SRP-without-antibiotics subgroups showed six significant correlations in both groups (p < 0.05); SRP-with-antibiotics subgroups showed 11 correlations in the younger and five in the elder group (p < 0.05).

Conclusions: NSPT improved clinical and hematological outcomes in stage III/IV grade C periodontitis patients over 6-8 weeks. Younger patients exhibited more significant changes than elder patients, especially in the SRP-without-antibiotics subgroup.

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非手术治疗对III/IV期C级牙周炎血液学指标的影响。

目的：探讨非手术牙周治疗对III/IV期C级牙周炎患者临床及血液学指标的短期影响。方法：纳入121例全身健康的III/IV期C级牙周炎患者。测定临床指标（斑块指数、探诊深度、出血指数、附着丧失）和血液学生物标志物[白细胞计数（WBC）、平均血小板体积（MPV）、中性粒细胞计数（NEUT）、中性粒细胞百分比（NEUT%）、淋巴细胞百分比（LYM%）]在NSPT前和NSPT后6-8周。患者分为年轻组（≤35岁）和老年组（bb0 ~ 35岁），根据全身抗生素使用情况进一步分层。采用卡方检验、配对t检验和Pearson相关进行分析。结果：两组患者的临床指标均有改善，WBC、NEUT、NEUT%均有降低，MPV、LYM%均有升高。含抗生素的srp亚组表现出更显著的变化。结论：NSPT改善了III/IV期C级牙周炎患者6-8周的临床和血液学结果。年轻患者比老年患者表现出更显著的变化，特别是在不使用抗生素的srp亚组中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.