Oral diseases最新文献_第3页

Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-30 DOI: 10.1111/odi.15242

Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi

{"title":"Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.","authors":"Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi","doi":"10.1111/odi.15242","DOIUrl":"https://doi.org/10.1111/odi.15242","url":null,"abstract":"Objectives: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ.Materials and methods: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed.Results: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities.Conclusions: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Analysis of Oral Microbiome and Metabolome in T2DM Patients With Varying Glycemic Status. 综合分析不同血糖状态的 T2DM 患者的口腔微生物组和代谢组

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-17 DOI: 10.1111/odi.15220

Jing Diao, Yanling Zhang, Xiaoli Zhang, Shuyuan Jia, Yajuan Lei, Bowen Ma, Xiaodong Li, Shuguo Zheng, Chao Yuan

{"title":"Integrated Analysis of Oral Microbiome and Metabolome in T2DM Patients With Varying Glycemic Status.","authors":"Jing Diao, Yanling Zhang, Xiaoli Zhang, Shuyuan Jia, Yajuan Lei, Bowen Ma, Xiaodong Li, Shuguo Zheng, Chao Yuan","doi":"10.1111/odi.15220","DOIUrl":"https://doi.org/10.1111/odi.15220","url":null,"abstract":"Objective: This study aimed to analyze the subgingival and salivary microbiome and metabolome in diabetic periodontitis patients with varying glycemic levels.Methods: Forty-two diabetic periodontitis patients were sampled of saliva, gingival crevicular fluid (GCF), and blood, and categorized into three groups based on systemic glycemic status. The microbiome was assessed using full-length 16S rRNA gene sequencing. Gas chromatography-mass spectrometry was performed for metabolome analysis.Results: The similarity in the structure and function of the flora in saliva and GCF was evident under good blood glucose control. Conversely, inadequate blood glucose control demonstrated a more distinct separation from saliva flora. Both salivary and GCF microorganisms exhibited greater periodontal pathogenicity, with salivary metabolites showing stronger associations with inflammation when Hemoglobin A1c (HbA1c) > 6.5%. Some periodontal pathogens, such as Veillonella atypica, showed significantly positive correlations with proinflammatory metabolites, including lactic acid and putrescine, etc. Salivary microbes demonstrated more sensitive responses than GCF to changes in blood glucose levels among type 2 diabetes mellitus (T2DM) patients.Conclusion: Under active blood glucose control, it indicates lower periodontal pathogenicity and inflammatory correlation in the oral microecology of T2DM patients. Saliva appears to offer superior diagnostic and monitoring value compared to GCF in the context of systemic disease surveillance.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-17 DOI: 10.1111/odi.15196

Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro

{"title":"Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.","authors":"Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro","doi":"10.1111/odi.15196","DOIUrl":"https://doi.org/10.1111/odi.15196","url":null,"abstract":"Objective: Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.Materials and methods: A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.Results: The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.Conclusion: HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply: "Surgical Treatment Compared With 'Wait and See' in Patients Affected by Oral Leukoplakia to Prevent Oral Cancer: Preliminary Data From a Multicenter Randomized Controlled Trial". 作者回复："口腔白斑病患者预防口腔癌的手术治疗与'观望'相比：一项多中心随机对照试验的初步数据"。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-17 DOI: 10.1111/odi.15229

Niccolò Lombardi, Paolo G Arduino, Marta Lampiano, Alessio Gambino, Roberto Broccoletti, Elena M Varoni, Giovanni Lodi

引用次数: 0

No Effect of the Pandemic on Trends in Chewing Difficulties and Oral Screening Among Korean Adults.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-17 DOI: 10.1111/odi.15221

Yoo Jeong Lee, In Cheol Hwang, Hong Yup Ahn, Yeyoung Park

引用次数: 0

Genetic Mutations Leading to Dento-Maxillofacial Abnormalities in Mice: A Systematic Review. 导致小鼠牙颌畸形的基因突变：系统性综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-17 DOI: 10.1111/odi.15223

Zuodong Zhao, Achiel Van Bruwaene, Ella Lievens, Marie De Laet, Catia Attanasio, Mariano Simón Pedano, María Cadenas de Llano-Pérula

{"title":"Genetic Mutations Leading to Dento-Maxillofacial Abnormalities in Mice: A Systematic Review.","authors":"Zuodong Zhao, Achiel Van Bruwaene, Ella Lievens, Marie De Laet, Catia Attanasio, Mariano Simón Pedano, María Cadenas de Llano-Pérula","doi":"10.1111/odi.15223","DOIUrl":"https://doi.org/10.1111/odi.15223","url":null,"abstract":"Introduction: To systematically review the available literature reporting on genetic mutations leading to dento-maxillofacial malformations in mice.Materials and methods: An electronic search was performed across Embase, PubMed, Web of Science, and Scopus databases up to May 2024, targeting all in vivo studies on gene mutations causing dento-maxillofacial deformities in mice. Studies reporting oral clefts were excluded. Data collected included genetic background, sex distribution, observation times, sample sizes, interventions, affected genes, zygosity, dento-maxillofacial anomalies, and associated human syndromes. Risk of bias was evaluated using the SYRCLE tool.Results: Of 12,968 articles, 215 were included. The most common genetic background was C57BL6/J (B6) (n = 83), and knock-out was the most common intervention (n = 142). A total of 172 studies included homozygous mice. The five most studied genes were Amelx, Bmp-2, Dspp, Enam, and Runx2. Dento-alveolar anomalies were more commonly reported (n = 175) than skeletal (n = 65). Skeletal anomalies were mostly related to micrognathia (n = 14), agnathia (n = 5), dysplasia (n = 1), or reduced jaw size (n = 14). Risk of bias was moderate.Conclusions: Key genes such as Amelx, Bmp-2, Dspp, Enam, and Runx2 implicated in dento-maxillofacial abnormalities in mice, detailing the most prevalent skeletal and dento-alveolar anomalies. These findings offer insights for developing gene therapy and diagnosing congenital malformations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Radiographs Findings Are Customary Abnomalies: Two Years Retrospective Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-13 DOI: 10.1111/odi.15222

Giselle Gadonski, Thiago Oliveira Gamba, Nádia Assein Arús, Pantelis Varvaki Rados

引用次数: 0

Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-13 DOI: 10.1111/odi.15219

Oscar Gabriel Castaño-Joaqui, Laura Jiménez Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo

{"title":"Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.","authors":"Oscar Gabriel Castaño-Joaqui, Laura Jiménez Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo","doi":"10.1111/odi.15219","DOIUrl":"https://doi.org/10.1111/odi.15219","url":null,"abstract":"Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS).Subjects and methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).Results: The structure of the associative pathways with the BMS was revealed. Direct associations involved Gastrointestinal Alterations (0.23), Vitamin D Deficiency (0.29), Musculoskeletal Alterations (0.29), Symptom Severity Score 2 (SSS2) (0.22), Cortisol Variation (0.10), Interpersonal Sensitivity (0.04), Hostility (0.03). Global Severity Index, Symptom Severity Score 1, Psychoticism, Obsession-Compulsion, Depression, Anxiety, and Somatization were indirectly related. The SSS2 was the most influential on BMS accuracy.Conclusions: Gastrointestinal alterations and vitamin D deficiency show a significant influence on BMS while cortisol mediates in multiple associative pathways between musculoskeletal alterations, gastrointestinal alterations, vitamin D deficiency, non-restorative sleep, fatigue, and cognitive problems. In addition to anxiety and depression, psychoticism, interpersonal sensitivity, and hostility stand out as psychological factors that seem to be related to a lack of vitamin D. None of the factors studied seem to have a relevant predictive potential for BMS, except for nonspecific symptoms of central sensitization.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Care Referral Delays in Oral Cancer Diagnosis: A Meta-Analysis.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-10 DOI: 10.1111/odi.15218

Juan Manuel Seoane Romero, Narmeen Mallah, Pablo Ignacio Varela-Centelles, Saman Warnakulasuriya, Bahi Takkouche

{"title":"Primary Care Referral Delays in Oral Cancer Diagnosis: A Meta-Analysis.","authors":"Juan Manuel Seoane Romero, Narmeen Mallah, Pablo Ignacio Varela-Centelles, Saman Warnakulasuriya, Bahi Takkouche","doi":"10.1111/odi.15218","DOIUrl":"https://doi.org/10.1111/odi.15218","url":null,"abstract":"Objective: To measure the primary care interval (PCI) in the diagnostic delay of oral cancer and to assess the relation of the referring physician's specialty with disease stage at diagnosis.Methods: We meta-analyzed reports of oral/oropharyngeal carcinomas detailing PCI start- and endpoints, i.e., the time needed by a primary care physician to refer a suspected oral cancer patient to a specialist.Results: 17 studies with a total of 2530 patients were eligible; nine provided data on the relative length of PCI, and 10 reported on the impact of the referring professional's specialty on oral cancer diagnostic delay. The average PCI length was slightly longer for general practitioners (GPs) (30.5 days) than for general dental practitioners (GDPs) (27.6 days), while that for the total group was 28.7 days. One-third of the total pre-hospital time spent on diagnosis elapses in GP practices (PCI%: 0.31 [95% CI: 0.23, 0.40]). GDPs refer their patients for treatment at earlier disease stages (TNM I-II) than GPs (Odds Ratio: 0.58; 95% CI: 0.34-0.98).Conclusions: Primary care accounts for a considerable pre-hospital amount of time of what is necessary for reaching a diagnosis of oral cancer patients. This calls for enhancing early oral cancer recognition in primary care settings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variants Influence the Severity of Oral Mucositis in Pediatric Osteosarcoma Patients.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-10 DOI: 10.1111/odi.15217

Renata de Almeida Zieger, Mariana Rodrigues Botton, Marina Curra, Amanda de Farias Gabriel, Stefanie Thieme, Luisa Comerlato Jardim, Marco Antonio Trevizani Martins, Ursula da Silveira Matte, André Tesainer Brunetto, Lauro José Gregianin, Rafael Roesler, Stephen T Sonis, Marina Siebert, Manoela Domingues Martins

{"title":"Genetic Variants Influence the Severity of Oral Mucositis in Pediatric Osteosarcoma Patients.","authors":"Renata de Almeida Zieger, Mariana Rodrigues Botton, Marina Curra, Amanda de Farias Gabriel, Stefanie Thieme, Luisa Comerlato Jardim, Marco Antonio Trevizani Martins, Ursula da Silveira Matte, André Tesainer Brunetto, Lauro José Gregianin, Rafael Roesler, Stephen T Sonis, Marina Siebert, Manoela Domingues Martins","doi":"10.1111/odi.15217","DOIUrl":"https://doi.org/10.1111/odi.15217","url":null,"abstract":"Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).Methods: A longitudinal observational retrospective study was conducted. Severity of OM was assessed daily using World Health Organization (WHO) criteria. Blood samples were collected, and DNA was extracted. 54 coding regions were analyzed for 17 candidate genes using next-generation sequencing.Results: A total of 164 CT cycles were evaluated in 14 pediatric patients being treated for OS with HDMTX (66.9%) and doxorubicin + cisplatin (34.1%). OM was diagnosed in 129 cycles (78.7%). Whereas the presence of OM was associated with ABCA3 (rs13332514) in HDMTX cycles, OM severity was associated with ABCC2 (rs2273697) in multivariate analysis. In doxorubicin + cisplatin, genetic variants of ABC family genes (ABCC2 and ABCC6) were associated with OM in multivariate analysis.Conclusion: Oral mucositis risk and severity in a pediatric population being treated for OS with HDMTX, doxorubicin, and cisplatin were associated with genes in the ABC family (ABCA3, ABCC2, and ABCC6 genes).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0