Oral diseases最新文献

{"title":"Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases.","authors":"Victor Zanetti Drumond, José Alcides Almeida de Arruda, Mariana Villaroel-Dorrego, Leonardo Amaral Dos Reis, Gerhilde Callou Sampaio, Lauren Frenzel Schuch, Carolina Louzada Menna-Barreto, Manoela Domingues Martins, Paula Celeghini Goulart, Guilherme Gomes Souza, Fabrício Tinôco Alvim de Souza, Warley Oliveira Silva, Karina Cordero-Torres, Rolando Morales-Espinosa, René Panico, Gerardo Gilligan, Federico Garola, Carlos Marcelo Cerullo, Nicolás Leonardi, Javier Giménez, Verónica Flück, Ángeles Castrillo, Laura Leguina, Claudia Patricia Peña-Vega, Juan Pablo Rodríguez-Mora, Kallana Mezzomo-Faccin, Ricardo Luiz Cavalcanti de Albuquerque-Junior, Rogério Gondak, Mônica Simões Israel, Pollianna Muniz Alves, Amanda Claudino Gomes, Cassiano Francisco Weege Nonaka, Michel Campos Ribeiro, Elismauro Francisco de Mendonça, Victor Hugo Lopes de Oliveira Moreira, Diego Antônio Costa Arantes, Israel Leal Cavalcante, Eveline Turatti, Roberta Barroso Cavalcante, Giovanna Tacchi, Ana Paula Neutzling Gomes, Karen Müller Bubolz, Adriana Etges, María Natalia González Umpiérrez, Natalia Fernanda Tancredi Cueto, Aurita Verónica Beovide-Cortegoso, Ronell Bologna-Molina, Saray Aranda-Romo, Francisco Javier Tejeda-Nava, Lucas Guimarães Abreu, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita","doi":"10.1111/odi.70519","DOIUrl":"https://doi.org/10.1111/odi.70519","url":null,"abstract":"<p><strong>Objective: </strong>Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment-related, and survival features of OSJ in Latin America.</p><p><strong>Methods: </strong>This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models.</p><p><strong>Results: </strong>A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months.</p><p><strong>Conclusion: </strong>Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Transformation in Oral Potentially Malignant Disorders.","authors":"Miguel Ángel González-Moles, Pablo Ramos-García, Saman Warnakulasuriya","doi":"10.1111/odi.70527","DOIUrl":"https://doi.org/10.1111/odi.70527","url":null,"abstract":"<p><strong>Background: </strong>In 2020, the World Health Organization (WHO) Collaborating Centre for Oral Cancer convened an international expert workshop to establish an updated consensus on the nomenclature and classification of oral potentially malignant disorders (OPMDs). The working group has defined OPMD as \"any oral mucosal abnormality that is associated with a statistically increased risk of developing oral cancer\", including leukoplakia, proliferative verrucous leukoplakia, erythroplakia, oral submucous fibrosis, oral lichen planus, actinic keratosis/actinic cheilitis, palatal lesions in reverse smokers, oral lupus erythematosus, dyskeratosis congenita, oral lichenoid lesions, and oral graft-versus-host disease.</p><p><strong>Methods: </strong>A literature search was conducted to identify the available evidence on the malignant transformation of OPMDs. Systematic reviews with meta-analyses quantifying malignant transformation risks were selected and critically analyzed through narrative synthesis.</p><p><strong>Results: </strong>Based on the available evidence, the malignant transformation risk is 6.64% (95% CI = 5.21-8.21) for oral leukoplakia, 1.40% (95% CI = 1.07-1.76) for oral lichen planus, 1.38% (95% CI = 0.16-3.38) for oral lichenoid lesions, 43.87% (95% CI = 31.93-56.13) for proliferative verrucous leukoplakia, and 6.00% (95% CI = 2.00-10.00) for oral submucous fibrosis. There is currently insufficient evidence regarding the malignant transformation of the remaining OPMDs.</p><p><strong>Conclusions: </strong>This narrative review presents the current evidence-based knowledge regarding the malignant transformation risks of the different OPMDs, with the aim of fulfilling the mission of the 3rd Global Oral Cancer Forum.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Biomarkers in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta-Analysis.","authors":"Madawi Faisal Alkeheli, Hisham I Othman","doi":"10.1111/odi.70520","DOIUrl":"https://doi.org/10.1111/odi.70520","url":null,"abstract":"<p><strong>Objective: </strong>To synthesise biological biomarker evidence in proliferative verrucous leukoplakia/proliferative leukoplakia and quantify malignant transformation using eligible longitudinal evidence.</p><p><strong>Methods: </strong>Primary human biomarker studies and longitudinal studies reporting extractable malignant-transformation events and denominators were systematically reviewed. Biomarker evidence was synthesised narratively. Malignant-transformation proportions were pooled using a random-effects model, with conservative handling of potentially overlapping cohorts.</p><p><strong>Results: </strong>Forty-one publications contributed to the biomarker synthesis, spanning genetic, genomic, DNA-ploidy, epigenetic, transcriptomic, proteomic, immunohistochemical, immunologic, viral, microbiome, salivary, and circulating markers. No biomarker had sufficient independent validation for clinical diagnostic or prognostic use. Twenty independent or conservatively non-overlapping study estimates comprising 745 patients and 243 malignant-transformation events contributed to the meta-analysis. The pooled malignant-transformation proportion was 34.13% (95% confidence interval 26.62-42.53), with substantial heterogeneity and a 95% prediction interval of 13.85%-62.56%. Results remained stable in sensitivity and leave-one-out analyses.</p><p><strong>Conclusions: </strong>Diverse biological alterations have been reported, but none currently supports routine biomarker-based diagnosis or individual risk stratification. Malignant transformation is frequent, although substantial between-study variability limits interpretation of the pooled estimate as an individual patient risk.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-17A Induces Chondrocyte Senescence via the STAT3-OPA1-mtROS Axis in Temporomandibular Joint Osteoarthritis.","authors":"Mengqi Zhu, Chunyan Zhang, Yangyang Zhang, Congdi Zhang, Zuping Wu, Ying Wang, Linghan Qu, Mengjie Wu, Minjuan Shen, Qianming Chen, Jiejun Shi","doi":"10.1111/odi.70369","DOIUrl":"https://doi.org/10.1111/odi.70369","url":null,"abstract":"<p><strong>Objectives: </strong>To elucidate the pathogenic mechanisms underlying interleukin-17A (IL-17A) induced chondrocyte senescence in TMJ-OA and provide preclinical evidence supporting IL-17A as a novel therapeutic target for TMJ-OA.</p><p><strong>Methods: </strong>We established a TMJ-OA mouse model using unilateral anterior crossbite (UAC) to investigate IL-17A expression and chondrocyte senescence. We subsequently cultured ATDC5 mouse chondrocytes with IL-17A in vitro to assess cellular senescence and further explored mitochondrial-related mechanisms. Finally, we evaluated the inhibitory effect of Secukinumab (an anti-IL-17A monoclonal antibody) on chondrocyte senescence and pathological progression in TMJ-OA mice.</p><p><strong>Results: </strong>Chondrocyte senescence is positively correlated with the expression of IL-17A in the condylar cartilage of TMJ-OA mice. IL-17A can induce cellular senescence in ATDC5 cells in vitro. Mechanistically, IL-17A increased the expression of the mitochondrial fusion-related protein optic atrophy 1 (OPA1) by increasing the phosphorylation level of signal transducer and activator of transcription 3 (STAT3). This caused mitochondrial hyperfusion and an increase in mitochondrial reactive oxygen species (mtROS), contributing to mitochondrial dysfunction and cellular senescence. Moreover, Secukinumab reduced chondrocyte senescence and inhibited pathological progression in TMJ-OA mice.</p><p><strong>Conclusion: </strong>IL-17A induces chondrocyte senescence by promoting mitochondrial dysfunction through a STAT3-OPA1-mtROS-dependent axis, and IL-17A may serve as a therapeutic target for the treatment of TMJ-OA.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Hamilton Anxiety and Depression Rating Scales in Oral Lichen Planus: A Multicenter Study by the Italian Society of Oral Pathology and Medicine.","authors":"Daniela Adamo, Gennaro Musella, Federica Canfora, Elena Calabria, Simone Liguori, Carlo Lajolo, Gioele Gioco, Giulia Ottaviani, Katia Rupel, Matteo Biasotto, Margherita Gobbo, Maddalena Manfredi, Paolo Vescovi, Amerigo Giudice, Cristina D'Antonio, Paolo Arduino, Alessio Gambino, Monica Pentenero, Olga Anna Furchì, Davide Bartolomeo Gissi, Andrea Gabusi, Lorenzo Azzi, Angelo Tagliabue, Gianluca Tenore, Andrea Santarelli, Andrea Sardella, Elena M Varoni, Giovanni Lodi, Giuseppina Campisi, Vera Panzarella, Michele Giuliani, Lorenzo Lo Muzio, Massimo Aria, Luca D'Aniello, Michele Davide Mignogna, Umberto Romeo","doi":"10.1111/odi.70518","DOIUrl":"https://doi.org/10.1111/odi.70518","url":null,"abstract":"<p><strong>Objective: </strong>To assess the psychometric performance of the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) in patients with oral lichen planus (OLP) according to clinical phenotype.</p><p><strong>Methods: </strong>This multicenter SIPMO case-control study included 395 participants: 132 patients with keratotic OLP (K-OLP), 131 with non-keratotic OLP (NK-OLP), and 132 healthy controls (HCs). Internal consistency was assessed with Cronbach's alpha and item discrimination with item-total correlations. HAM-A and HAM-D scores were compared between OLP patients and HCs; phenotype-specific hierarchical regressions identified variables associated with anxiety and depressive symptoms.</p><p><strong>Results: </strong>HAM-A and HAM-D showed satisfactory internal consistency in K-OLP and NK-OLP patients (HAM-A α = 0.877 and 0.858; HAM-D α = 0.768 and 0.766, respectively). Patients with OLP had significantly higher HAM-A and HAM-D scores than age- and sex-matched controls without oral mucosal disease (p = 0.018 and p = 0.002, respectively). The strongest item-total correlations involved depressed mood, tension, insomnia, and somatic symptoms. Poor sleep quality was independently associated with psychological burden, and pain intensity independently predicted anxiety severity in NK-OLP patients.</p><p><strong>Conclusions: </strong>HAM-A and HAM-D showed satisfactory psychometric performance in OLP and may support psychological assessment. Somatic and sleep-related symptoms were closely associated with psychological distress.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Status in Patients With Oral Lichen Planus: A Case-Control Study.","authors":"Cosimo Rupe, Francesco Scilla, Gioele Gioco, Michele Candian, Raffaella Castagnola, Romeo Patini, Luigi Barbato, Francesco Cairo, Carlo Lajolo","doi":"10.1111/odi.70522","DOIUrl":"https://doi.org/10.1111/odi.70522","url":null,"abstract":"<p><strong>Background: </strong>The aim was to evaluate periodontitis prevalence and severity, and number of RT1 gingival recessions in Oral Lichen Planus (OLP) patients compared with non-OLP controls.</p><p><strong>Methods: </strong>This case-control study was conducted between 2024 and 2025 at the Oral Medicine Unit, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy. A total of 176 individuals were enrolled: 88 histologically confirmed OLP patients and 88 age/sex-matched controls. Periodontal status was assessed using major clinical indices and classified according to the 2017 AAP/EFP case definition. Ethics Committee UCSC, ID-7603; ClinicalTrials.gov (NCT07597616).</p><p><strong>Results: </strong>Periodontitis prevalence was significantly higher in OLP patients than controls (71.6% vs. 51.1%; OR: 2.99; 95% CI: 1.44-6.21, p = 0.03) as was severe periodontitis (48.9% vs. 30.7%; OR: 3.06; 95% CI: 1.44-6.47, p = 0.004). RT1 recessions were more frequent in OLP (p = 0.008). A significant association between mean CAL and OLP severity was identified (OR = 1.67; 95% CI: 1.03-2.72; p = 0.03).</p><p><strong>Conclusions: </strong>Patients with OLP showed a higher prevalence of periodontitis and a higher prevalence of severe forms in the overall study population. The association with RT1 recessions in the absence of periodontitis suggests a relationship between mucosal inflammation on periodontal tissues and should be further explored.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Band-Like Chronic Inflammatory Infiltrate in Proliferative Verrucous Leukoplakia: A Meta-Analysis.","authors":"Daniel Lobato Ferreira Ferraz, Brenda Corrêa Santos, Ana Carolina Evangelista Colafêmina, Ivan José Correia-Neto, Alan Roger Santos-Silva, Marcio Ajudarte Lopes","doi":"10.1111/odi.70514","DOIUrl":"https://doi.org/10.1111/odi.70514","url":null,"abstract":"<p><strong>Objective: </strong>Proliferative verrucous leukoplakia is an oral potentially malignant disorder with a difficult diagnosis. A band-like chronic inflammatory infiltrate is frequently described in early lesions, but its prevalence and prognostic relevance remain unclear. This study aimed to estimate the prevalence of this feature in proliferative verrucous leukoplakia and assess its prognostic value.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted according to PRISMA guidelines, with protocol registration in PROSPERO (CRD420251249570). Electronic databases and gray literature were searched. Observational studies reporting a band-like chronic inflammatory infiltrate in lesions from patients with proliferative verrucous leukoplakia were included. Data extraction and risk of bias assessment were performed independently. Random effects models estimated pooled prevalence and odds ratios for malignant transformation.</p><p><strong>Results: </strong>Eleven studies including 307 patients were analyzed. The pooled prevalence of a band-like chronic inflammatory infiltrate was 57%. Malignant transformation occurred in 39.5% of cases with this feature and 53% of cases without it. Meta-analysis revealed no statistically significant association between a band-like chronic inflammatory infiltrate and malignant transformation.</p><p><strong>Conclusions: </strong>Band-like chronic inflammatory infiltrates are common in proliferative verrucous leukoplakia, but current evidence is insufficient to determine whether this feature is associated with malignant transformation and clinically meaningful effects cannot be excluded.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Artificial Intelligence in Dental Trauma.","authors":"Tatsuya Akitomo, Masakazu Hamada, Satoru Kusaka, Jimei Zhao, Ryota Nomura","doi":"10.1111/odi.70529","DOIUrl":"https://doi.org/10.1111/odi.70529","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Antioxidant: The Multifaceted Role of Resveratrol as an Antibacterial, Immunomodulatory, and Pro-Regenerative Agent in Periodontitis.","authors":"Yu-Jie Tan, Mei Xu, Yue-Hua Ran, Nan Jia, Rui-Xin Wu, Bei-Min Tian, Fa-Ming Chen","doi":"10.1111/odi.70516","DOIUrl":"https://doi.org/10.1111/odi.70516","url":null,"abstract":"<p><strong>Objective: </strong>Periodontitis treatment centers on three pillars: antibacterial, anti-inflammatory, and regenerative approaches. This review aims to demonstrate that resveratrol (RSV) simultaneously targets all three core components, positioning it as a multifunctional disease-modifying agent.</p><p><strong>Methods: </strong>We conducted a narrative review of RSV in periodontitis by searching PubMed and Web of Science from inception to July 2026. Rather than focusing solely on its well-established antioxidant properties, we comprehensively investigated its multifaceted mechanisms across the three key pathological dimensions.</p><p><strong>Results: </strong>RSV demonstrates broad-spectrum antibacterial activity by inhibiting biofilm formation, suppressing bacterial ATP synthase, inducing DNA damage, and disrupting efflux pumps to counteract antibiotic resistance. RSV modulates host immune responses through multiple signaling pathways, primarily via SIRT1-mediated epigenetic regulation. RSV also interacts with immune cells and regulates innate immune memory, thereby reducing the risk of disease recurrence associated with trained immunity-induced hyperinflammation. Furthermore, RSV orchestrates stem cell recruitment via SDF-1α signaling and cytoskeletal reorganization, while directing cell differentiation through mitochondrial quality control and epigenetic modifications, thereby promoting endogenous periodontal regeneration.</p><p><strong>Conclusions: </strong>This review provides a comprehensive analysis of the multifaceted roles of RSV in antibacterial action, immunomodulation, and tissue regeneration, highlighting its potential as a multifunctional agent against the complex pathological progression of periodontitis.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Biomarker Changes After Non-Surgical Periodontal Treatment in Young Adults With Stage III/IV Grade C Periodontitis.","authors":"Dilek Guvenc, Serdar Cintan, Pinar Soguksu, Ulku Baser, Silvi Domnori, Aslan Yasar Gokbuget, Alpdogan Kantarci","doi":"10.1111/odi.70524","DOIUrl":"https://doi.org/10.1111/odi.70524","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the impact of non-surgical periodontal treatment (NSPT) on systemic inflammatory phenotype and lipid profiles in young adults with severe (Stage III-IV/Grade C) periodontitis.</p><p><strong>Methods: </strong>Thirty systemically healthy patients with severe periodontitis and 20 healthy controls were recruited in this prospective, parallel-group controlled study. Periodontal parameters and systemic biomarkers, including inflammatory, endothelial, and lipid biomarkers, were evaluated at baseline and re-measured at 2 and 6 months post-NSPT.</p><p><strong>Results: </strong>Significant reductions in periodontal parameters were observed after 2 months and remained stable over 6 months (p < 0.001), while bleeding, probing pocket depth, and clinical attachment levels remained significantly higher in the periodontitis patients compared to the healthy group (p < 0.05). Circulating hs-CRP, triglycerides, vWf, IL-6, IL-1ra, tPA, sTNFRII, and albumin were significantly higher while HDL cholesterol was significantly lower in periodontitis patients at baseline compared to the healthy controls (p < 0.05). hs-CRP, IL-6, IL-1ra, sTNFRI, and tPA significantly decreased; HDL cholesterol significantly increased after NSPT (p < 0.05). HDL cholesterol, vWf, IL-6, and sTNFRII levels remained significantly different from those of the healthy group at 6 months (p < 0.05).</p><p><strong>Conclusion: </strong>NSPT improved periodontal status; however, systemic biomarkers did not uniformly return to health reference levels, indicating a need for a more comprehensive medical approach.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}