Oral diseases最新文献_第3页

Spin and Hacking in Machine Learning Prediction Model Studies in Dentistry: A Systematic Review. 旋转和黑客在牙科机器学习预测模型研究中的应用：系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-08 DOI: 10.1111/odi.70023

Liandi Cheng, Yixuan Pan, Po-Kam Wo, Yunhao Zheng, Yating Yi, Ji Woon Park, Xin Xiong

{"title":"Spin and Hacking in Machine Learning Prediction Model Studies in Dentistry: A Systematic Review.","authors":"Liandi Cheng, Yixuan Pan, Po-Kam Wo, Yunhao Zheng, Yating Yi, Ji Woon Park, Xin Xiong","doi":"10.1111/odi.70023","DOIUrl":"https://doi.org/10.1111/odi.70023","url":null,"abstract":"Objectives: As machine learning and prediction model research grows in popularity, researchers may be tempted to exaggerate the value of their models through misleading reporting (spin) or statistical manipulation (hacking). This study assessed spin and potential hacking in machine learning-based prediction model studies in dentistry.Methods: Six databases were searched to identify studies published up to October 12, 2024. 2780 eligible studies were identified, and 1206 AUC values were extracted from abstracts for hacking analysis. For spin assessment, 209 studies were selected and evaluated based on the SPIN-PM framework.Results: The histogram of AUC values showed fluctuations near thresholds (0.7 and 0.8), suggesting potential AUC-hacking evidence. Spin practices were identified in 37.3% (n = 78) assessed studies, mainly through unjustified use of optimistic or positive words to describe model performance and claims of clinical applicability without external validation. Facilitators of spin were found in 39.2% (n = 82) of studies, with the most frequent being the reporting of performance measures without confidence intervals.Conclusions: The spin practices and facilitators were prevalent, and some evidence of hacking was found. We suggest considering the 'TRIAL' (Transparency, Reporting, Integrity, Adjustment, and Learning) principles to guide machine learning prediction model studies in dentistry, thereby minimizing spin and hacking.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Pleomorphic Adenoma of the Parotid Gland: Proposal for an LMCG Classification System and an Optimized Therapeutic Algorithm. 复发性腮腺多形性腺瘤：LMCG分类系统和优化治疗算法的建议。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-04 DOI: 10.1111/odi.70022

Qicheng Ye, Dongrui Liu, Lingli Huang, Wenya Zhu, Hao Lu, Wenjun Yang, Wanlin Xu

{"title":"Recurrent Pleomorphic Adenoma of the Parotid Gland: Proposal for an LMCG Classification System and an Optimized Therapeutic Algorithm.","authors":"Qicheng Ye, Dongrui Liu, Lingli Huang, Wenya Zhu, Hao Lu, Wenjun Yang, Wanlin Xu","doi":"10.1111/odi.70022","DOIUrl":"https://doi.org/10.1111/odi.70022","url":null,"abstract":"Objectives: To introduce a novel clinical classification system and corresponding therapeutic strategies for parotid recurrent pleomorphic adenoma (RPA).Methods: A retrospective analysis was conducted on parotid RPA cases treated by a single surgical team at Shanghai Ninth People's Hospital between January 2020 and December 2024. Based on tumor features-such as single or multiple nodules, infringement of adjacent structures, or skip metastases-as well as intraoperative facial nerve status, a classification system and corresponding treatment strategy were proposed.Results: A total of 66 patients were included in the study. The majority (95.5%) presented with multinodular tumors, and 66.7% developed facial paralysis due to intraoperative facial nerve injury. The classification system termed \"Localized-Moderate-Complicated-General\" (LMCG) was first developed. The Localized type represents the least severe condition, while the subsequent categories reflect progressively more complex presentations. Each classification corresponds to a tailored therapeutic strategy, ranging from partial parotidectomy with or without facial nerve preservation to extensive parotidectomy combined with immediate nerve reconstruction and adjuvant radiotherapy.Conclusion: The LMCG classification offers a concise framework for preoperative assessment and personalized treatment planning in patients with parotid RPA, with the potential to standardize and improve its clinical outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of the Tumour Mutational Burden in Erosive and Reticular Oral Lichen Planus. 糜烂性与网状口腔扁平苔藓肿瘤突变负荷的比较分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-04 DOI: 10.1111/odi.70020

Priscila Laiza Rubim Leão, Rennan Garcias Moreira, Fernanda Faria Rocha, Laura de Freitas Xavier, Larissa Rany Martins-Chaves, Ana Carolina Carneiro Batista de Oliveira, Soraya de Mattos Camargo Grossmann Almeida, Silvia Ferreira de Sousa, Marina Gonçalvez Diniz, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez

{"title":"Comparative Analysis of the Tumour Mutational Burden in Erosive and Reticular Oral Lichen Planus.","authors":"Priscila Laiza Rubim Leão, Rennan Garcias Moreira, Fernanda Faria Rocha, Laura de Freitas Xavier, Larissa Rany Martins-Chaves, Ana Carolina Carneiro Batista de Oliveira, Soraya de Mattos Camargo Grossmann Almeida, Silvia Ferreira de Sousa, Marina Gonçalvez Diniz, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez","doi":"10.1111/odi.70020","DOIUrl":"https://doi.org/10.1111/odi.70020","url":null,"abstract":"Objective: Oral lichen planus (OLP) is a chronic inflammatory disease classified as an oral potentially malignant lesion. The erosive and reticular forms of OLP have the potential for malignant transformation, with no consistent data indicating that one form is more likely to undergo malignant transformation than the other. Tumour mutational burden (TMB) is a parameter that represents the number of somatic mutations in the DNA of neoplastic cells. This study aimed to compare TMB levels in the two primary clinical forms of OLP, the erosive and reticular sub-types.Methods: Next-generation sequencing of samples from 18 patients with OLP, including nine of each clinical form, was performed using the QIAseq Targeted DNA Human TMB Panel.Results: Eight (44.4%) of the samples had a TMB ≤ 10 mutations/Mb, while 10 (55.6%) had a TMB of zero. No significant difference was observed between the erosive and reticular forms of OLP. A maximum of two somatic variations per sample was identified, involving genes associated with immune response (PTPRD, PSMA6 and CD274) and tumour suppression (PALB2, ATRX and BRCA2).Conclusion: Although these data suggest that genetic mutational events occur similarly in erosive and reticular OLP, further molecular studies are required to confirm the findings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aldehyde Dehydrogenase 6 Family Member A1 Facilitates Ti Implant Osseointegration in Hyperlipidemia. 醛脱氢酶6家族成员A1促进Ti植入物在高脂血症中的骨整合。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-04 DOI: 10.1111/odi.15342

Ya-Nan Wang, Lu Yu, Yingxue Liu, Xin Xu, Dongjiao Zhang, Shiyue Liu, Shaohua Ge

{"title":"Aldehyde Dehydrogenase 6 Family Member A1 Facilitates Ti Implant Osseointegration in Hyperlipidemia.","authors":"Ya-Nan Wang, Lu Yu, Yingxue Liu, Xin Xu, Dongjiao Zhang, Shiyue Liu, Shaohua Ge","doi":"10.1111/odi.15342","DOIUrl":"https://doi.org/10.1111/odi.15342","url":null,"abstract":"Objective: Hyperlipidemia seriously impairs titanium (Ti) implant osseointegration, and endogenous therapeutic targets remain elusive. Aldehyde dehydrogenase 6 family member A1 (ALDH6A1) plays an important role in redox regulation and lipid metabolism. However, its role in osseointegration under hyperlipidemia conditions has not been thoroughly investigated. This study aimed to elucidate the potential role of ALDH6A1 in implant osseointegration in hyperlipidemia mice.Materials and methods: ALDH6A1 expression levels were detected in peri-implant tissue and in primary osteoblasts by qRT-PCR and western blot. The role of ALDH6A1 in reducing oxidative damage and improving osseointegration on Ti implant surface was evaluated by locally overexpressing ALDH6A1 with a lentiviral vector in peri-implant tissue in hyperlipidemia mice.Results: ALDH6A1 expression significantly decreased in hyperlipidemia mice, compared with normal mice (p < 0.05). ALDH6A1 was downregulated in a high-fat environment, and silencing ALDH6A1 led to osteogenic dysfunction in osteoblasts. ALDH6A1 overexpression maintained redox homeostasis and osteogenic activity of primary osteoblasts and facilitated osseointegration in hyperlipidemia mice by reducing oxidative damage in peri-implant tissue.Conclusion: ALDH6A1 is a key protein for facilitating osseointegration by alleviating reactive oxygen species levels in hyperlipidemia, and developing specific ALDH6A1 agonists would be a promising strategy for ameliorating osseointegration in hyperlipidemia patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Oral Medicine Practice Is Reported: A Scoping Review of 114,971 Patients. 如何报道口腔医学实践：114,971例患者的范围审查。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-02 DOI: 10.1111/odi.70017

Camila Barcellos Calderipe, Laura Borges Kirschnick, Alini Cardoso Soares, Ana Carolina Uchoa Vasconcelos, Marcio Ajudarte Lopes, Nathaniel Simon Treister, Alan Roger Santos-Silva

{"title":"How Oral Medicine Practice Is Reported: A Scoping Review of 114,971 Patients.","authors":"Camila Barcellos Calderipe, Laura Borges Kirschnick, Alini Cardoso Soares, Ana Carolina Uchoa Vasconcelos, Marcio Ajudarte Lopes, Nathaniel Simon Treister, Alan Roger Santos-Silva","doi":"10.1111/odi.70017","DOIUrl":"https://doi.org/10.1111/odi.70017","url":null,"abstract":"Objective: This review aimed to: (i) identify the variables used by oral medicine services (OMS) to describe the scope of their clinical practices and (ii) identify gaps in the availability of these variables in the literature to guide future research on the characterisation of OM practices. To address the following question: What characteristics from studies on clinical practice have been used to describe the scope of practice in OM?Material and methods: This scoping review followed the PRISMA-ScR guidelines. Electronic searches were conducted in the following databases: PubMed, Scopus, Embase, Web of Science, LILACS and grey literature. The presence of the following variables was assessed: referral source, age, sex, medical profile, diagnosis, procedures and follow-up.Results: A total of 12 studies met the eligibility criteria, comprising 15 OMS across 10 countries and including 114,971 patients. Some studies specifically aimed to characterise OMS practice, while others focused on specific aspects of these practices. Most studies examined variables such as referral source, age, sex and diagnosis.Conclusions: There are gaps in the description of the OMS scope of practice in the literature, particularly regarding patient follow-up, characterisation of the range of procedures performed and documentation of patients' medical profiles.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review. 牙周治疗对代谢综合征参数的影响：系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-02 DOI: 10.1111/odi.70018

Anna Simonelli, Filippo Citterio, Fabio Falcone, Francesco D'Aiuto, Nicola Marco Sforza, Salvatore Corrao, Giorgio Sesti, Leonardo Trombelli

{"title":"Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.","authors":"Anna Simonelli, Filippo Citterio, Fabio Falcone, Francesco D'Aiuto, Nicola Marco Sforza, Salvatore Corrao, Giorgio Sesti, Leonardo Trombelli","doi":"10.1111/odi.70018","DOIUrl":"https://doi.org/10.1111/odi.70018","url":null,"abstract":"Aim: To evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis.Methods: A systematic search was conducted to identify randomized controlled trials (RCTs) with a follow-up ≥ 1 month comparing a more intense periodontal treatment (test intervention) to either a less intense or no periodontal treatment (control intervention). MS parameters such as triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and systemic inflammatory biomarkers (i.e., C-reactive protein, CRP) were analyzed. Random-effects meta-regression analyses were conducted at 3- and 6-month follow-ups.Results: Four RCTs were included. Test intervention resulted in a statistically significant greater SBP reduction at 3 (WMD 1.48) and 6 (WMD 1.88) months compared to control group. A statistically significant difference between groups was observed for FBG at 6 months after treatment, favoring test intervention (WMD 0.61). No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.Conclusions: Periodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.Trial registration: This systematic review was registered under the protocol registration number CRD42024499854/PROSPERO.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Non-Smoking and Non-Drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumors". 点评“不吸烟不饮酒口腔癌患者发生第二原发肿瘤的风险较高”

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-01 DOI: 10.1111/odi.15352

Pouria Farahani, Sajad Sabahi, Mohamad Rezaei

引用次数: 0

Preventive Treatments for Osteonecrosis of the Jaw: A Systematic Review and Network Meta-Analysis. 颌骨骨坏死的预防性治疗：系统综述和网络荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-01 DOI: 10.1111/odi.70015

Lucas Nascimento Ribeiro, Raisa Severino-Lazo, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas de Moraes, Marianne de Vasconcelos Carvalho

{"title":"Preventive Treatments for Osteonecrosis of the Jaw: A Systematic Review and Network Meta-Analysis.","authors":"Lucas Nascimento Ribeiro, Raisa Severino-Lazo, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas de Moraes, Marianne de Vasconcelos Carvalho","doi":"10.1111/odi.70015","DOIUrl":"https://doi.org/10.1111/odi.70015","url":null,"abstract":"Objectives: A systematic review and network meta-analysis were conducted to address the following research question: \"What is the most effective preventive treatment for reducing the risk of jaw osteonecrosis after tooth extraction in patients receiving medications associated with osteonecrosis?\"Material and methods: Only randomized clinical trials conducted in adults with a history of medication use associated with osteonecrosis of the jaw, who were treated with a preventive method to reduce the risk of osteonecrosis after tooth extraction, were included. Risk of bias and quality of evidence were assessed using the Cochrane Collaboration tool. Bayesian random-effects mixed treatment comparison model was employed to compare all evaluated strategies: regenerative therapy, primary closure, secondary closure, epiperiosteal flap, and ozone infiltration. The network meta-analysis results were presented as point estimates with 95% credible intervals.Results: Five randomized clinical trials conducted between 2012 and 2024 were included after applying the predetermined criteria. These studies evaluated various interventions, including platelet-rich fibrin, platelet-rich plasma, oxygen-ozone therapy, and different surgical closure techniques. Bayesian network meta-analysis demonstrated no conclusive evidence of superiority for any intervention over primary closure.Conclusion: No preventive strategy demonstrated superiority in reducing the risk of medication-related osteonecrosis of the jaw in patients undergoing tooth extraction.Trial registration: International Prospective Register of Systematic Reviews: CRD42024619828.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Bruxism Self-Report and Awake Bruxism: An Ecological Momentary Assessment. 睡眠磨牙症自我报告和清醒磨牙症：生态瞬间评估。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-01 DOI: 10.1111/odi.15400

Aurora Manfredini, Ovidiu Ionut Saracutu, Marco Ferrari, Matteo Pollis, Daniele Manfredini

{"title":"Sleep Bruxism Self-Report and Awake Bruxism: An Ecological Momentary Assessment.","authors":"Aurora Manfredini, Ovidiu Ionut Saracutu, Marco Ferrari, Matteo Pollis, Daniele Manfredini","doi":"10.1111/odi.15400","DOIUrl":"https://doi.org/10.1111/odi.15400","url":null,"abstract":"Objectives: The present study seeks to investigate the association between sleep bruxism (SB) and awake bruxism (AB) in healthy individuals, assessing whether self-reported SB is associated with higher AB frequency through self-report and Ecological Momentary Assessment (EMA).Methods: A cohort of 150 healthy participants (57 males, 93 females; mean age 25.53 ± 3.4 years), recruited at the University of Siena, completed the A1.1 and A1.2 domains of the Standardized Tool for the Assessment of Bruxism (STAB). Among them, 100 underwent a seven-day EMA via a smartphone application to track AB behaviors. Mann-Whitney U tests compared self-reported and EMA-reported AB frequencies between SB and non-SB individuals, while Spearman correlation tested SB-AB associations (p < 0.05).Results: SB was reported by 34% of participants. These individuals showed significantly higher self-reported AB behaviors, including teeth clenching (p < 0.001), mandible bracing (p = 0.039), and teeth grinding (p = 0.014). EMA confirmed increased AB frequencies, particularly teeth clenching (p = 0.005), mandible bracing (p = 0.02), and teeth contact (p = 0.047) in SB individuals. Spearman analysis revealed a mild-to-moderate correlation between SB and AB (p < 0.01).Conclusions: SB is significantly associated with AB behaviors, suggesting that individuals reporting SB are more likely to engage in AB activities.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Deep Learning for Staging Periodontitis Using Panoramic Radiographs". 关于“利用全景x线片进行牙周炎分期的深度学习”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-01 DOI: 10.1111/odi.15347

Mohammad Reza Keivany, Ali Assare, Ali Hosseini

引用次数: 0