Oral diseases最新文献_第4页

Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15216

Vy Ngoc Thuy Tran, Komkrit Ruangritchankul, Nikolaos G Nikitakis, Somponnat Sampattavanich, Joao N Ferreira, Risa Chaisuparat

{"title":"Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma.","authors":"Vy Ngoc Thuy Tran, Komkrit Ruangritchankul, Nikolaos G Nikitakis, Somponnat Sampattavanich, Joao N Ferreira, Risa Chaisuparat","doi":"10.1111/odi.15216","DOIUrl":"https://doi.org/10.1111/odi.15216","url":null,"abstract":"Objectives: To define tumor immunoarchitectural patterns (IPs) and characterize the immune profile in salivary gland mucoepidermoid carcinoma (MEC) toward assessing MEC prognostic significance and implications for immunotherapy.Methods: This study analyzed 41 MEC cases, evaluating the tumor IPs and tumor-infiltrating lymphocyte (TIL) parameters by using whole-slide imaging and AI-assisted assessment. Immunohistochemistry of CD3 and CD8 markers was performed to assess key lymphocyte subpopulations.Results: Immune-rich (I-rich) tumors were characterized by high TIL density and were associated with aggressive tumor behavior, particularly in histological high-grade MEC, with a significant increase in TIL density observed in the inner invasive margin compartment (p < 0.05). I-rich tumor cases were linked to poorer disease-free survival (DFS) (Breslow = 4.686, p = 0.03). Aggressive MEC cases displayed a highly heterogeneous TIL profile, however, no TIL patterns showed a significant impact on DFS (p > 0.05).Conclusions: Despite the high immunogenicity suggested by the abundance of T lymphocytes, the protective role of CD8+ T lymphocytes was not prominent in MEC. I-rich tumors appeared more aggressive and unfavorable MEC cases exhibited high heterogeneity in their TIL profiles. Interrogating the role of TILs in the inner invasive tumor margin may offer a new mechanistic understanding for future immunotherapy discovery.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAM-Derived Exosomes Promote EMT by Upregulating lncRNA MIR4435-2HG in Head and Neck Cancer.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15212

Junjiang Liu, Jingtian Mu, Zhi Liang, Yizhi Zhang, Tao Hu, Fanglong Wu, Hongmei Zhou

{"title":"TAM-Derived Exosomes Promote EMT by Upregulating lncRNA MIR4435-2HG in Head and Neck Cancer.","authors":"Junjiang Liu, Jingtian Mu, Zhi Liang, Yizhi Zhang, Tao Hu, Fanglong Wu, Hongmei Zhou","doi":"10.1111/odi.15212","DOIUrl":"https://doi.org/10.1111/odi.15212","url":null,"abstract":"Objective: This study aimed to investigate the impact of tumor-associated macrophage (TAM)-derived exosomes on epithelial-mesenchymal transition (EMT) in head and neck squamous cell carcinoma (HNSCC) and the underlying mechanisms involved.Subjects and methods: Exosomes were isolated and characterized using transmission electron microscopy, nanoparticle size analysis, and western blotting. The effect on EMT in HNSCC cells was assessed using wound healing, transwell invasion, and EMT marker assays. Bioinformatics analysis was conducted to predict key TAM-related long noncoding RNAs and evaluate their relationship with EMT in HNSCC.Results: We observed that treatment with TAM-derived conditioned medium (CM) promoted EMT in HNSCC cells. Within the CM, we observed abundant exosomes that were taken up by HNSCC cells. Furthermore, TAM-derived exosomes promoted EMT in HNSCC cells. Mechanistically, high MIR4435-2HG expression levels were observed in TAM-derived exosomes and in HNSCC cells after treatment with TAM-derived exosomes. Notably, high MIR4435-2HG expression levels may be closely related to molecules that promote EMT in HNSCC.Conclusions: TAM-derived exosomes promote EMT in HNSCC cells by upregulating MIR4435-2HG expression, suggesting that MIR4435-2HG is a candidate target for HNSCC therapy.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent oral ulcer on a man's tongue.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15138

Shuangshuang Wu, Jianyun Zhang, Zhimin Yan

引用次数: 0

Extracellular Vesicles From LPS-Treated PDLSCs Induce NLRP3 Inflammasome Activation in Periodontitis.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15210

Yeke Wu, Jiawei Li, Min Liu, Ranran Gao, Hongling Zhou, Qiongying Hu, Lixing Zhao, Yunfei Xie

{"title":"Extracellular Vesicles From LPS-Treated PDLSCs Induce NLRP3 Inflammasome Activation in Periodontitis.","authors":"Yeke Wu, Jiawei Li, Min Liu, Ranran Gao, Hongling Zhou, Qiongying Hu, Lixing Zhao, Yunfei Xie","doi":"10.1111/odi.15210","DOIUrl":"https://doi.org/10.1111/odi.15210","url":null,"abstract":"Objective: This study aimed to investigate the effects of lipopolysaccharide (LPS)-pretreated primary periodontal ligament stem cell (PDLSC)-derived extracellular vesicles (EVs) (L-PDLSC-EVs) on periodontitis.Materials and methods: PDLSCs were obtained from mouse periodontal ligaments via enzymatic digestion. An in vitro inflammatory microenvironment for PDLSCs was established using LPS, and L-PDLSC-EVs were isolated through ultracentrifugation and identified. EVs from different treatments were co-incubated with RAW264.7 macrophages (Mφs) or periodontal ligament fibroblasts (PLFs) and their co-cultures, whereafter the biological behaviors in Mφs and PLFs were evaluated. Periodontitis mouse models were established to verify the role of L-PDLSC-EVs and the mechanisms involved.Results: There were no significant changes in the characteristics of L-PDLSC-EVs compared with control EVs. L-PDLSC-EVs promoted M1-type Mφ polarization and activated the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome. Furthermore, L-PDLSC-EVs promoted PLF cytotoxicity and apoptosis by enhancing the M1 polarization of Mφs. In periodontitis mouse models, L-PDLSC-EVs facilitated alveolar bone loss, PLF injury, and inflammatory responses, accompanied by an increased proportion of M1-type Mφs and reinforced NLRP3 inflammasome activation.Conclusions: L-PDLSC-EVs promoted PLF injury and exacerbated periodontitis through activating the NLRP3 inflammasome and promoting the polarization of M1-type Mφs, providing novel insights for the periodontitis progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15203

Alessandro Zangani, Miriana Gualtieri, Alessia Pardo, Annarita Signoriello, Paolo Faccioni, Gianluca Colapinto, Funda Goker, Giorgio Lombardo, Massimo Del Fabbro, Massimo Albanese

{"title":"Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review.","authors":"Alessandro Zangani, Miriana Gualtieri, Alessia Pardo, Annarita Signoriello, Paolo Faccioni, Gianluca Colapinto, Funda Goker, Giorgio Lombardo, Massimo Del Fabbro, Massimo Albanese","doi":"10.1111/odi.15203","DOIUrl":"https://doi.org/10.1111/odi.15203","url":null,"abstract":"Objective: To evaluate the outcome of collagen matrix (CMX) compared with subepithelial connective tissue graft (SCTG) in gingival recession coverage (RC) surgery.Methods: Review protocol was registered in PROSPERO. The search was conducted on MEDLINE, Cochrane Library, and Scopus databases. Randomized studies comparing CMX versus. SCTG or CMX versus. covering procedures without any filling material, for class I recession treatment were included. Risk of bias assessment and quantitative analysis were performed.Results: Of 168 records, 11 randomized clinical trials were included. The meta-analysis revealed no statistically significant difference in terms of %RC (p = 0.37); there was a statistically significant difference in terms of recession reduction (p = 0.02) and keratinized tissue width (p = 0.03) in favor of SCTG cases. CMX showed a statistically significantly better result compared to no grafting, regarding %RC (p = 0.003) and keratinized tissue thickness (p < 0.0001). The duration of the intervention was significantly shorter for CMX than for SCTG (p < 0.0001).Conclusion: CMX can be considered a viable material, especially when a ΔKTt increase and a reduction of intervention duration is needed. The indications for the choice, however, may depend on the individual local condition. PROSPERO Registration: Registration in PROSPERO (International prospective register of systematic reviews): CRD42024555443.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulomatous ulcer affecting the hard and soft palate in a young patient.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-06 DOI: 10.1111/odi.15127

Isabel Schausltz Pereira Faustino, Leonardo Dos Santos Bayeh, Danillo Batista Silveira, Irineu Maia, Joab Cabral Ramos

引用次数: 0

Schwann Cell-Mediated M2-Like Macrophage Polarization in Rhabdomyosarcoma.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-05 DOI: 10.1111/odi.15214

Guanying Feng, Yibo Guo, Mingtao Chen, Yu Zhang, Zheqi Liu, Chen Sun, Xin Hu, Chengzhong Lin, Yu Liu, Yue Wu, Hao Wu, Xi Yang, Yang Wang, Jinhai Ye, Jiannan Liu, Xu Wang, Tong Ji, Chenping Zhang

{"title":"Schwann Cell-Mediated M2-Like Macrophage Polarization in Rhabdomyosarcoma.","authors":"Guanying Feng, Yibo Guo, Mingtao Chen, Yu Zhang, Zheqi Liu, Chen Sun, Xin Hu, Chengzhong Lin, Yu Liu, Yue Wu, Hao Wu, Xi Yang, Yang Wang, Jinhai Ye, Jiannan Liu, Xu Wang, Tong Ji, Chenping Zhang","doi":"10.1111/odi.15214","DOIUrl":"https://doi.org/10.1111/odi.15214","url":null,"abstract":"Objective: To investigate the cellular components and immunological characteristics of the head and neck rhabdomyosarcoma (RMS) microenvironment.Methods: We conducted single-cell transcriptomics to analyze the cellular components of the RMS microenvironment. CellChat was utilized for analyzing intercellular interactions. The cancer genome atlas database was used for validation. CIBERSORT was applied for immune infiltration profiling. Functional enrichment analyses were performed using the Kyoto Encyclopedia of Genes and Genomes. Gene set scores were calculated using single-sample gene set enrichment analysis. Subcutaneous allograft models and bulk RNA sequencing were used for validation. Flow cytometry and immunohistochemistry were used to identify M2-like macrophages.Results: Our findings revealed an extremely low presence of neutrophils in RMS samples compared with normal sample. RMS sample with high Schwann cell infiltration exhibited an increase in M2-like macrophage infiltration. Receptor-ligand pairs, specifically MIF-CD74 and PTN-SDC3, were identified between Schwann cells and M2-like macrophages. In the RMS sample characterized by significant Schwann cell infiltration, M2-like macrophages demonstrate robust expression of axon guidance factors and are enriched in the axon guidance pathway.Conclusions: Our study provides valuable insights into the microenvironment and immunological characteristics of RMS, offering crucial information for further research and potential therapeutic strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taste Perception and Saliva Composition Are Not Altered in Burning Mouth Syndrome.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-03 DOI: 10.1111/odi.15201

Marina Kolkka, Satu Jääskeläinen, Heli Forssell, Auli Suominen, Tuija Teerijoki-Oksa, Vuokko Loimaranta, Merja A Laine, Mari Sandell

{"title":"Taste Perception and Saliva Composition Are Not Altered in Burning Mouth Syndrome.","authors":"Marina Kolkka, Satu Jääskeläinen, Heli Forssell, Auli Suominen, Tuija Teerijoki-Oksa, Vuokko Loimaranta, Merja A Laine, Mari Sandell","doi":"10.1111/odi.15201","DOIUrl":"https://doi.org/10.1111/odi.15201","url":null,"abstract":"Objectives: To study the connections between burning mouth syndrome (BMS) and taste perception and saliva, and interactions between saliva and taste in BMS patients compared to age- and gender-matched control subjects.Materials and methods: A total of 31 BMS patients (43-82 years) and 20 age- and gender-matched volunteers (44-78 years) participated. The taste sensation for six tastants was measured using both the taste strips protocol and the whole-mouth evaluation method. Stimulated saliva was collected for 5 min. Salivary flow rate, pH, electrolyte concentrations (sodium, potassium, and calcium), MUC5B, MUC7, dehydroepiandrosterone (DHEA), and total protein were measured.Results: No differences were found between the groups in taste, salivary flow rate, or composition. A weak association between saliva composition and taste modalities was found within both groups. Metallic taste phantom was reported only by BMS patients (p = 0.03).Conclusions: In contrast to most previous reports, BMS patients did not differ from control subjects in any of the six taste modalities tested nor did the salivary variables differ between the groups. The relationship between salivary variables and total taste score was weak but similar in both groups. Further research with larger study samples is needed to confirm these results.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Treatment-Induced Head and Neck Malignancies in Cancer Survivors.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-01 DOI: 10.1111/odi.15213

Fábio Muradás Girardi, Gustavo Guthmann Pesenatto, Larissa Dill Fuchs, Thomas Peter Maahs, Nathaniel S Treister, Gerson Schulz Maahs

引用次数: 0

Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer.

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-01 DOI: 10.1111/odi.15215

Katerina Kopecka, Michal Herman, Jaroslav Michalek, Jana Zapletalova, Marketa Hermanova, Priska Liptakova, Michal Hendrych, Michal Mozola, Richard Pink

{"title":"Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer.","authors":"Katerina Kopecka, Michal Herman, Jaroslav Michalek, Jana Zapletalova, Marketa Hermanova, Priska Liptakova, Michal Hendrych, Michal Mozola, Richard Pink","doi":"10.1111/odi.15215","DOIUrl":"https://doi.org/10.1111/odi.15215","url":null,"abstract":"Objectives: Tumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.Materials and methods: The study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.Results: Significant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.Conclusions: The ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0