Oral diseases最新文献_第4页

The Potential of Artificial Intelligence in Dental Trauma. 人工智能在牙外伤中的潜力。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-29 DOI: 10.1111/odi.70529

Tatsuya Akitomo, Masakazu Hamada, Satoru Kusaka, Jimei Zhao, Ryota Nomura

引用次数: 0

Beyond Antioxidant: The Multifaceted Role of Resveratrol as an Antibacterial, Immunomodulatory, and Pro-Regenerative Agent in Periodontitis. 超越抗氧化剂：白藜芦醇在牙周炎中作为抗菌、免疫调节和促再生剂的多方面作用。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-29 DOI: 10.1111/odi.70516

Yu-Jie Tan, Mei Xu, Yue-Hua Ran, Nan Jia, Rui-Xin Wu, Bei-Min Tian, Fa-Ming Chen

{"title":"Beyond Antioxidant: The Multifaceted Role of Resveratrol as an Antibacterial, Immunomodulatory, and Pro-Regenerative Agent in Periodontitis.","authors":"Yu-Jie Tan, Mei Xu, Yue-Hua Ran, Nan Jia, Rui-Xin Wu, Bei-Min Tian, Fa-Ming Chen","doi":"10.1111/odi.70516","DOIUrl":"https://doi.org/10.1111/odi.70516","url":null,"abstract":"Objective: Periodontitis treatment centers on three pillars: antibacterial, anti-inflammatory, and regenerative approaches. This review aims to demonstrate that resveratrol (RSV) simultaneously targets all three core components, positioning it as a multifunctional disease-modifying agent.Methods: We conducted a narrative review of RSV in periodontitis by searching PubMed and Web of Science from inception to July 2026. Rather than focusing solely on its well-established antioxidant properties, we comprehensively investigated its multifaceted mechanisms across the three key pathological dimensions.Results: RSV demonstrates broad-spectrum antibacterial activity by inhibiting biofilm formation, suppressing bacterial ATP synthase, inducing DNA damage, and disrupting efflux pumps to counteract antibiotic resistance. RSV modulates host immune responses through multiple signaling pathways, primarily via SIRT1-mediated epigenetic regulation. RSV also interacts with immune cells and regulates innate immune memory, thereby reducing the risk of disease recurrence associated with trained immunity-induced hyperinflammation. Furthermore, RSV orchestrates stem cell recruitment via SDF-1α signaling and cytoskeletal reorganization, while directing cell differentiation through mitochondrial quality control and epigenetic modifications, thereby promoting endogenous periodontal regeneration.Conclusions: This review provides a comprehensive analysis of the multifaceted roles of RSV in antibacterial action, immunomodulation, and tissue regeneration, highlighting its potential as a multifunctional agent against the complex pathological progression of periodontitis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Biomarker Changes After Non-Surgical Periodontal Treatment in Young Adults With Stage III/IV Grade C Periodontitis. 年轻人III/IV期C级牙周炎非手术治疗后的全身生物标志物变化

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-29 DOI: 10.1111/odi.70524

Dilek Guvenc, Serdar Cintan, Pinar Soguksu, Ulku Baser, Silvi Domnori, Aslan Yasar Gokbuget, Alpdogan Kantarci

{"title":"Systemic Biomarker Changes After Non-Surgical Periodontal Treatment in Young Adults With Stage III/IV Grade C Periodontitis.","authors":"Dilek Guvenc, Serdar Cintan, Pinar Soguksu, Ulku Baser, Silvi Domnori, Aslan Yasar Gokbuget, Alpdogan Kantarci","doi":"10.1111/odi.70524","DOIUrl":"https://doi.org/10.1111/odi.70524","url":null,"abstract":"Background: This study aimed to evaluate the impact of non-surgical periodontal treatment (NSPT) on systemic inflammatory phenotype and lipid profiles in young adults with severe (Stage III-IV/Grade C) periodontitis.Methods: Thirty systemically healthy patients with severe periodontitis and 20 healthy controls were recruited in this prospective, parallel-group controlled study. Periodontal parameters and systemic biomarkers, including inflammatory, endothelial, and lipid biomarkers, were evaluated at baseline and re-measured at 2 and 6 months post-NSPT.Results: Significant reductions in periodontal parameters were observed after 2 months and remained stable over 6 months (p < 0.001), while bleeding, probing pocket depth, and clinical attachment levels remained significantly higher in the periodontitis patients compared to the healthy group (p < 0.05). Circulating hs-CRP, triglycerides, vWf, IL-6, IL-1ra, tPA, sTNFRII, and albumin were significantly higher while HDL cholesterol was significantly lower in periodontitis patients at baseline compared to the healthy controls (p < 0.05). hs-CRP, IL-6, IL-1ra, sTNFRI, and tPA significantly decreased; HDL cholesterol significantly increased after NSPT (p < 0.05). HDL cholesterol, vWf, IL-6, and sTNFRII levels remained significantly different from those of the healthy group at 6 months (p < 0.05).Conclusion: NSPT improved periodontal status; however, systemic biomarkers did not uniformly return to health reference levels, indicating a need for a more comprehensive medical approach.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theories and Practices on Developing Various Models of Betel Quid Cessation in Taiwan. 台湾发展各种槟榔戒烟模式的理论与实践

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-29 DOI: 10.1111/odi.70523

Ming-Shinn Lee, Yi-Jung Tsai

{"title":"Theories and Practices on Developing Various Models of Betel Quid Cessation in Taiwan.","authors":"Ming-Shinn Lee, Yi-Jung Tsai","doi":"10.1111/odi.70523","DOIUrl":"https://doi.org/10.1111/odi.70523","url":null,"abstract":"Objective: This review examines the development and outcomes of Taiwan's betel quid cessation models over two decades. Betel quid, the world's fourth most used psychoactive substance, receives far less cessation attention than tobacco.Methods: We present a narrative synthesis of program evaluations and national implementation data from Taiwan (2007-2025), analyzing the Transtheoretical Model, Health Belief Model, Theory of Planned Behavior, social cognitive theory, and ecological and nudge frameworks against program design and outcomes.Results: Six models were developed sequentially. In the 8 h community program, 96% initiated cessation by course end, 53% stopped chewing entirely, and 64% remained abstinent at 1 year tracking. A 4 h workplace program achieved 69% point-prevalence cessation among 166 workers (consumption: 49.8-2.1 quids/day). A 3 min clinic intervention advanced 32% of 246 patients a stage. Case management matched group delivery in stage progression while reaching remote populations; school prevention improved student knowledge and attitudes in 54-73 schools yearly. An AI-assisted curriculum-design tool remains in pilot testing.Conclusions: Taiwan shows that theory-driven, culturally sensitive, multi-model programs can substantially reduce betel quid use, offering a transferable framework for other high-prevalence regions. Most outcome evidence comes from single-group, self-reported evaluations; confirmation in controlled trials is a regional priority.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Cancer Screening in the Global Status Report on Cancer 2026: Whose Evidence, and Whose Responsibility? 2026年全球癌症现状报告中的口腔癌筛查：谁的证据，谁的责任？

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-28 DOI: 10.1111/odi.70494

Ignacio Retamal Fariña

引用次数: 0

Sleep Quality and Risk of Periodontal Disease: A Systematic Review and Meta-Analysis. 睡眠质量与牙周病风险：一项系统综述和荟萃分析。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-28 DOI: 10.1111/odi.70511

Binbin Nan, Jing Kang, Honghui Wei, Xiaojun Li, Qianming Chen, Zijian Cheng

{"title":"Sleep Quality and Risk of Periodontal Disease: A Systematic Review and Meta-Analysis.","authors":"Binbin Nan, Jing Kang, Honghui Wei, Xiaojun Li, Qianming Chen, Zijian Cheng","doi":"10.1111/odi.70511","DOIUrl":"https://doi.org/10.1111/odi.70511","url":null,"abstract":"Objective: Sleep regulates immune and inflammatory processes and may influence periodontal health, though evidence remains inconsistent. This meta-analysis evaluated the association between sleep characteristics, including sleep quality and sleep duration, and periodontal disease (PD).Methods: Systematic searches up tos May 2025 identified eligible studies. Sleep-related exposures were assessed using validated questionnaires or sleep duration (< 7 h); periodontal outcomes were defined by clinical examination or self-report. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model, depending on heterogeneity.Results: Fourteen studies (n = 126,425) met inclusion criteria, of which nine (n = 55,524) provided adjusted odds ratios for meta-analysis. Six assessed questionnaire-based sleep quality and three assessed sleep duration alone. Across these heterogeneous exposure definitions, adverse sleep characteristics were associated with greater odds of PD (OR = 1.25; 95% CI: 1.11-1.41; p < 0.001, I2 = 53.8%). Sensitivity analyses showed no substantial change in the pooled estimate, and no statistically significant evidence of publication bias was detected.Conclusions: Adverse sleep characteristics were associated with greater odds of PD, with a stronger association observed for severe periodontitis in subgroup analysis. However, the certainty of evidence was very low, and prospective studies are warranted to clarify causality.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Nonsurgical Periodontal Therapy on Cathepsin-K in Saliva and Gingival Crevicular Fluid. 非手术牙周治疗对唾液和龈沟液组织蛋白酶- k的影响。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-28 DOI: 10.1111/odi.70509

Ali Batuhan Bayırlı, Ayla Öztürk, Mehmetcan Uytun, Ercan Saruhan

{"title":"Impact of Nonsurgical Periodontal Therapy on Cathepsin-K in Saliva and Gingival Crevicular Fluid.","authors":"Ali Batuhan Bayırlı, Ayla Öztürk, Mehmetcan Uytun, Ercan Saruhan","doi":"10.1111/odi.70509","DOIUrl":"https://doi.org/10.1111/odi.70509","url":null,"abstract":"Objective: The aim of this study was to investigate the association between Cathepsin K (CatK) levels in gingival crevicular fluid (GCF) and saliva with periodontal health and disease, and to evaluate the effects of non-surgical periodontal therapy (NSPT) on these biomarkers.Methods: GCF and saliva samples were collected from periodontally healthy individuals (n = 33) and patients diagnosed with periodontitis (n = 33). The periodontitis group underwent NSPT, and follow-up samples were collected from the same individuals one month after treatment. CatK concentrations in both GCF and saliva were measured using ELISA.Results: At baseline, CatK levels in both GCF and saliva were significantly higher in periodontitis patients than in periodontally healthy controls (p < 0.001). NSPT resulted in significant reductions in CatK levels in both GCF and saliva (p < 0.001). Salivary CatK decreased to values comparable to healthy subjects, whereas GCF CatK, although reduced, remained higher than healthy levels. A strong positive correlation between salivary and GCF CatK observed before treatment (r = 0.88, p < 0.001) disappeared after NSPT. Multiple regression identified cohort and gingival index as the strongest independent predictors of CatK concentrations.Conclusion: CatK levels in both GCF and saliva were associated with periodontal status and responded significantly to NSPT. These findings suggest that CatK may have potential as an adjunctive biomarker for monitoring short-term biochemical changes following NSPT.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological and Microbiological Findings in Psoriatic Arthritis, Psoriasis, and Periodontitis Individuals. 银屑病关节炎、银屑病和牙周炎患者的免疫学和微生物学研究。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-28 DOI: 10.1111/odi.70512

Amanda Almeida Costa, Luís Otávio Miranda Cota, Rafael Paschoal Esteves Lima, Alcione Maria Soares Dutra Oliveira, Sheila Cavalca Cortelli, José Roberto Cortelli, Tarcília Aparecida Silva, Fernando Oliveira Costa

{"title":"Immunological and Microbiological Findings in Psoriatic Arthritis, Psoriasis, and Periodontitis Individuals.","authors":"Amanda Almeida Costa, Luís Otávio Miranda Cota, Rafael Paschoal Esteves Lima, Alcione Maria Soares Dutra Oliveira, Sheila Cavalca Cortelli, José Roberto Cortelli, Tarcília Aparecida Silva, Fernando Oliveira Costa","doi":"10.1111/odi.70512","DOIUrl":"https://doi.org/10.1111/odi.70512","url":null,"abstract":"Objectives: Emerging evidence suggests a link between psoriasis (PSO), psoriatic arthritis (PSA), and periodontitis (PE), similar to other systemic conditions. This study aimed to evaluate the levels of Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans (qPCR), as well as salivary biomarkers RANKL, OPG, Survivin, and IL-17 (ELISA) in individuals with PSO and PSA, compared to non-psoriatic controls with and without PE.Subjects and methods: From a case-control study (n = 655), 192 non-smokers and non-diabetics were randomly selected and divided into six gender-matched groups (n = 32 each): control, PSO, and PSA, with and without PE.Results: Higher counts of P. gingivalis, T. forsythia, and T. denticola were found in individuals with PE, particularly in PSA + PE and PSO + PE groups, along with significant intergroup differences in IL-17 and survivin, with higher levels in PSA than PSO and controls. In PSA + PE individuals, OPG, IL-17, and survivin were significantly increased. Positive correlations were observed between RANKL, IL-17, survivin, and clinical periodontal parameters, with negative correlations for OPG (p < 0.001).Conclusions: Psoriatic individuals with PE show higher levels of classical red-complex periodontopathogens and heightened inflammatory biomarker levels, especially in PSA. These findings highlight the need for integrated care between dermatologists and periodontists.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply "Tumor Budding Is a Promising Indicator for Elective Neck Dissection in Node-Negative Early-Stage Oral Squamous Cell Carcinoma: A Retrospective Cohort Study". 作者回复“肿瘤出芽是淋巴结阴性早期口腔鳞状细胞癌择期颈部清扫的一个有希望的指标：一项回顾性队列研究”。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-23 DOI: 10.1111/odi.70507

Zhuqin Xiang, Zehang Zhuang, Jinsong Hou, Cheng Wang

引用次数: 0

Authors' Reply "Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa". 作者回复“大疱性表皮松解症患者脱落的口腔细胞遗传不稳定性增加”。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-22 DOI: 10.1111/odi.70504

Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama-de-Souza

引用次数: 0