Oral diseases最新文献_第4页

Mutational Landscape of Ameloblastoma: Analysis of BRAF and Other Key Mutations in Chinese Patients. 成釉细胞瘤的突变景观：中国患者BRAF和其他关键突变的分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-03 DOI: 10.1111/odi.15286

Zhu You, Zihan Sima, Xiaowen Guo, Xuefen Li, Yanrui Feng, Ning Du, Heyu Zhang, Lisha Sun

{"title":"Mutational Landscape of Ameloblastoma: Analysis of BRAF and Other Key Mutations in Chinese Patients.","authors":"Zhu You, Zihan Sima, Xiaowen Guo, Xuefen Li, Yanrui Feng, Ning Du, Heyu Zhang, Lisha Sun","doi":"10.1111/odi.15286","DOIUrl":"https://doi.org/10.1111/odi.15286","url":null,"abstract":"Objectives: To investigate the prevalence of BRAF, SMO, KRAS, HRAS, NRAS, FGRF2, and CTNNB1 gene mutations in Chinese ameloblastoma (AM) patients and explore their associations with clinical characteristics.Materials and methods: DNA was extracted from 89 formalin-fixed paraffin-embedded AM samples (9 unicystic and 80 conventional). PCR and Sanger sequencing were used to detect mutations, followed by statistical analysis to assess correlations between mutations and clinical variables.Results: BRAF V600E mutations were significantly prevalent, occurring in 92% (59/64) of mandibular AMs compared to 40% (10/25) in maxillary AMs. SMO mutations were found in 20% (5/25) of maxillary and 3.1% (2/64) of mandibular AMs. FGFR2 mutations were detected in six maxillary and two mandibular AMs, while RAS mutations were present in four maxillary and one mandibular AM. No detectable HRAS, NRAS(G12), or CTNNB1 mutations were observed. BRAF mutations showed mutual exclusivity with SMO and FGFR2 mutations.Conclusion: The high prevalence of BRAF V600E mutations, particularly in mandibular AMs, suggests its potential as a diagnostic and therapeutic target. Distinct mutation profiles between maxillary and mandibular AMs indicate molecular diversity. In BRAF-negative cases, alternative oncogenic pathways involving SMO, FGFR2, and RAS may be actionable targets, underscoring the need for personalized treatment approaches.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular Dysfunction and Sleep Apnea in Dutch Adults With Osteogenesis Imperfecta. 荷兰成人成骨不全的颞下颌功能障碍和睡眠呼吸暂停。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-03 DOI: 10.1111/odi.15280

L Blokland, E de Kuijper-Timmermans, M de Kuijper, K Gooijer, G J Harsevoort, M C Zillikens, N M Appelman-Dijkstra, G J M Janus, S Kalaykova

{"title":"Temporomandibular Dysfunction and Sleep Apnea in Dutch Adults With Osteogenesis Imperfecta.","authors":"L Blokland, E de Kuijper-Timmermans, M de Kuijper, K Gooijer, G J Harsevoort, M C Zillikens, N M Appelman-Dijkstra, G J M Janus, S Kalaykova","doi":"10.1111/odi.15280","DOIUrl":"https://doi.org/10.1111/odi.15280","url":null,"abstract":"Objective: This study investigated self-reported symptoms of temporomandibular disorders, mandibular functional impairment, and obstructive sleep apnea among Dutch adults with Osteogenesis Imperfecta.Materials and methods: A cross-sectional online survey was distributed among Dutch adults with Osteogenesis Imperfecta. Possible risk factors for self-reported temporomandibular disorders (3Q/TMD; DC/TMD), mandibular impairments (Mandibular Function Impairment Questionnaire), and obstructive sleep apnea (STOP-Bang) were explored using univariate and multiple regression analyses.Results: 31% of 155 respondents reported temporomandibular disorder symptoms and 40.0% and 5.2% moderate and severe mandibular function impairment, respectively. Intermediate and severe risk for obstructive sleep apnea were reported by 16.1% and 14.8%, respectively. Female gender and Osteogenesis Imperfecta type III were independently associated with the presence of self-reported temporomandibular disorders. Osteogenesis Imperfecta type III, missing teeth, and self-reported temporomandibular disorders were independently associated with impaired mandibular function. Higher age, male gender, and bisphonate use were independently associated with a higher risk for positive screening for obstructive sleep apnea.Conclusions: A substantial proportion of Dutch adults with Osteogenesis Imperfecta reported symptoms indicative of temporomandibular disorders, mandibular function impairment, and higher risk for obstructive sleep apnea. Especially Osteogenesis Imperfecta type III patients are at risk for self-reported temporomandibular disorders and hampered mandibular function.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis. 植物化学物质对口腔癌转移影响的临床前和临床证据。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-03 DOI: 10.1111/odi.15293

Murugesan Amirtha Varshini, Arikketh Devi

{"title":"Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis.","authors":"Murugesan Amirtha Varshini, Arikketh Devi","doi":"10.1111/odi.15293","DOIUrl":"https://doi.org/10.1111/odi.15293","url":null,"abstract":"Objective: This review focuses on the clinical and preclinical studies pertaining to the use of phytochemicals in the prevention of Oral Squamous Cell Carcinoma (OSCC) metastasis.Methods: A thorough overview of the relevant literature was provided by the narrative review approach. The PubMed, Google Scholar, and Scopus databases were used to retrieve publications on the phytochemicals preventing oral cancer metastasis. Clinical trials of phytochemicals on oral cancer patients were retrieved from https://clinicaltrials.gov/.Results: An increasing number of scientific literature provides evidence suggesting that phytochemicals might possess the capacity to impede cancer invasion and metastasis. Plant extracts and phytochemical substances, including genistein, curcumin, lycopene, resveratrol, isothiocyanates, and green tea extract, have shown promise in recent novel research as potential weapons against this cancer.Conclusion: A crucial prognostic factor for oral cancer is distant metastasis (DM). Chemoprevention is a comprehensive concept that encompasses the use of synthetic or natural substances to impede the development or progression of cancer. This current literature review enumerates the data supporting these potential phytochemicals' benefits in OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Anticoagulant Heparin: An In Vitro Investigation of a Novel Therapeutic Approach for Oral Cancer. 非抗凝肝素：一种口腔癌新治疗方法的体外研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-03-03 DOI: 10.1111/odi.15288

S A Hamza, R Paolini, N M O'Brien-Simpson, W Singleton, R Patini, M McCullough, A Celentano

{"title":"Non-Anticoagulant Heparin: An In Vitro Investigation of a Novel Therapeutic Approach for Oral Cancer.","authors":"S A Hamza, R Paolini, N M O'Brien-Simpson, W Singleton, R Patini, M McCullough, A Celentano","doi":"10.1111/odi.15288","DOIUrl":"https://doi.org/10.1111/odi.15288","url":null,"abstract":"Background: Oral squamous cell carcinoma (OSCC) represents a significant global oral health concern. Non-anticoagulant heparin (NH) emerges as a promising solution considering the enhanced survival observed with anticoagulants in cancer treatment.Methods: We used the MTS assay (0/24/48/72 h), scratch assay (MuviCyte, 0-18 h), invasion Matrigel (24 h), and cytotoxic assay (0-24 h) to assess the in vitro effects of NH and heparin (10, 20, 40, 80 U/mL) on three oral human cell lines (H400/H357/OKF6) as well as their ability to interfere with the chemotherapeutic agents 5FU and cisplatin (1-5 μg/mL).Results: Remarkably, NH not only significantly induced a significant cytotoxic effect on both cancer cell lines at 80 U/mL but also inhibited proliferation at 48/72 h to a comparable extent as heparin. Notably, neither drug exhibited cytotoxic effects on the normal cells. Furthermore, in H400/H357 cells, both heparin and NH significantly inhibit the cell migration and invasion rate. Importantly, the combination of these drugs with commonly used chemotherapeutic agents for OSCC treatment did not compromise their efficacy against the tested cell lines.Conclusion: NH demonstrates promising potential without compromising the efficacy of commonly used chemotherapeutic agents. These results underscore the need for the translation of this research to preclinical animal models.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are We There Yet? A Comment on Gender Equity in Brazilian Dental Research. 我们到了吗？巴西牙科研究中的性别平等问题评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-27 DOI: 10.1111/odi.15296

Árlen Almeida Duarte de Sousa, Daniella Reis Barbosa Martelli, Fabrício Emanuel Soares de Oliveira, Eduardo A Oliveira, Ricardo D Coletta, Hercílio Martelli Júnior

引用次数: 0

Periodontitis: Grade Modifiers Revisited. 牙周炎：分级调节剂再访。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-27 DOI: 10.1111/odi.15297

Obada Saleh, Anas Abdulmunim, Ibrahim Aboushakra, Maanas Shah, Abeer Hakam, Nabeel H M Alsabeeha, Momen A Atieh

{"title":"Periodontitis: Grade Modifiers Revisited.","authors":"Obada Saleh, Anas Abdulmunim, Ibrahim Aboushakra, Maanas Shah, Abeer Hakam, Nabeel H M Alsabeeha, Momen A Atieh","doi":"10.1111/odi.15297","DOIUrl":"https://doi.org/10.1111/odi.15297","url":null,"abstract":"Objective: This review aimed to propose new grade modifiers for the risk assessment of periodontitis.Materials and methods: Literature on the known risk factors, current, and potential grade modifiers was reviewed.Results: The transition to a staging and grading system for periodontitis was driven by the need for consistent and comprehensive classification that facilitates diagnosis and personalized treatment planning. The new system assesses severity and complexity based on clinical attachment loss, radiographic bone loss, and patient history, and integrates risk factors into the grading scheme as grade modifiers. The two commonly used grade modifiers are smoking and diabetes mellitus. The changes to grade B or C are based on the number of cigarettes smoked per day and the level of glycemic levels, which are known thresholds used in association studies of risk factors for periodontitis. New grade modifiers such as systemic inflammatory response, rheumatoid arthritis, osteoporosis, obesity, and neurodegenerative disease were identified.Conclusion: While adding grade modifiers may increase complexity, they could improve the prognostic accuracy of the current classification, enabling more precise assessment, personalized treatment, and better management of periodontitis, especially in patients with systemic risk factors.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controversies in Lip Cancer Staging Assessment: Insights and Perspectives. 唇癌分期评估的争议：见解和观点。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-27 DOI: 10.1111/odi.15298

Fabio Muradás Girardi, Manoela Domingues Martins

引用次数: 0

Pathogenesis of Orofacial Pain Based on Brain Circuits. 基于脑回路的口面部疼痛发病机制。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-27 DOI: 10.1111/odi.15299

Takahiko Nagamine

引用次数: 0

DDX5 Alleviates Temporomandibular Joint Osteoarthritis via TNF-Induced NF-κB Signaling Pathway. DDX5通过tnf诱导的NF-κB信号通路缓解颞下颌关节骨性关节炎。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-27 DOI: 10.1111/odi.15294

Qingqing Liang, Peiru Han, Mingrui Han, Mengjia Wang, Qing Zhao, Yuan Zhang, Chuanjin Ye, Sheng Chen, Bing Fang, Yang Sun, Jun Ji

{"title":"DDX5 Alleviates Temporomandibular Joint Osteoarthritis via TNF-Induced NF-κB Signaling Pathway.","authors":"Qingqing Liang, Peiru Han, Mingrui Han, Mengjia Wang, Qing Zhao, Yuan Zhang, Chuanjin Ye, Sheng Chen, Bing Fang, Yang Sun, Jun Ji","doi":"10.1111/odi.15294","DOIUrl":"https://doi.org/10.1111/odi.15294","url":null,"abstract":"Background: Temporomandibular joint osteoarthritis (TMJOA) is a prevalent musculoskeletal condition characterized by pain, cartilage degeneration, and subchondral bone loss.Objective: This study sought to identify specific targets for the treatment of TMJOA.Method: Through high-throughput RNA-seq analysis in condylar chondrocytes (NC vs. MS), we discovered that DDX5 was downregulated and closely negatively related to the progression of TMJOA. Similarly, we found that DDX5 was downregulated in injured condylar cartilage of patients as well as the condyles of UAC-induced TMJOA mice. The chondrocyte-specific deletion of Ddx5 aggravated tissue destruction in TMJOA modeling by inducing degradation of extracellular matrix (ECM).Results: The loss of DDX5 facilitated chondrocyte degradation and the occurrence of joint inflammation in condylar chondrocytes. In addition, the local injection of AAV overexpressing DDX5 significantly alleviated inflammation, cartilage degradation, and subchondral bone loss in TMJOA mice. RNA-seq analysis revealed that the DDX5 deficiency mostly activated the TNF-induced nuclear factor-kappa B (NF-κB) signaling pathway causing the occurrence of TMJOA.Conclusion: Mechanistically, the inhibition of DDX5 accelerated cartilage degeneration by activating TNF-induced NF-κB signaling. Thus, DDX5 emerges as a potential effective drug target for future therapeutic approaches in TMJOA.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering Disulfidptosis-Linked lncRNA Patterns as Potential HNSCC Biomarkers. 解读与二硫酸化相关的lncRNA模式作为潜在的HNSCC生物标志物。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15283

Qi Chen, Xiao Shi, Yuanyuan Bao, Yue Chen

{"title":"Deciphering Disulfidptosis-Linked lncRNA Patterns as Potential HNSCC Biomarkers.","authors":"Qi Chen, Xiao Shi, Yuanyuan Bao, Yue Chen","doi":"10.1111/odi.15283","DOIUrl":"https://doi.org/10.1111/odi.15283","url":null,"abstract":"Background: Our investigation sought to uncover the intrinsic features of Head and Neck Squamous Cell Carcinoma (HNSCC), particularly the role of long non-coding RNAs implicated in disulfidptosis (DRLs).Materials and methods: We carried out lncRNA-mRNA RNA-Seq studies on HNSCC cells and harnessed the data from The Cancer Genome Atlas (TCGA), which includes 522 HNSCC tumors and 44 normal specimens. Bioinformatics evaluations aided in recognizing DRLs and estimating their prognostic value. Furthermore, we built a predictive model related to the chosen DRLs to scrutinize its linkage with the patients' prognosis. We also dug into tumor mutation loads and responses to chemotherapy.Results: Our study identified three key DRLs (LINC02434, AC245041.2, and LINC02762) with considerable correlation to HNSCC prognosis. The risk model, utilizing these DRLs, successfully categorized patients into high-risk and low-risk clusters, uncovering differential survival trajectories. Moreover, the same risk model conveyed unique prognostic potential in HNSCC. Surveying the tumor microenvironment unfolded disparities between the groups, hinting toward potential implications for tactics in immunotherapy. We recognized distinct chemotherapeutic drugs with fluctuating responses across the risk clusters and molecular categories.Conclusion: This investigation not only sheds light on prospective therapeutic pathways but also enhances our grasp of the molecular intricacies of HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0