Oral diseases最新文献_第4页

Developing Anticancer Redox Chemotherapeutics: Challenges and Opportunities. 发展抗癌氧化还原化疗：挑战与机遇。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70085

Suman Kumar Ray, Manohar S Kugaji, Anjanapura Venkataramanaiah Raghu

引用次数: 0

Cardiovascular Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis. 牙周炎的心血管生物标志物：一项系统综述和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70084

Vandana Gupta, Anika Dawar, Sumit Kumar Das, Vikender Singh Yadav, Vanshita Nalwa, Razia Haidrus, Bharathi M Purohit, Lata Goyal

{"title":"Cardiovascular Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Vandana Gupta, Anika Dawar, Sumit Kumar Das, Vikender Singh Yadav, Vanshita Nalwa, Razia Haidrus, Bharathi M Purohit, Lata Goyal","doi":"10.1111/odi.70084","DOIUrl":"https://doi.org/10.1111/odi.70084","url":null,"abstract":"Aim: This review aimed to synthesize evidence on cardiovascular biomarkers associated with periodontitis, identified in biofluids such as blood, saliva, and gingival crevicular fluid (GCF).Methods: A comprehensive search of five databases was conducted to identify studies comparing cardiovascular biomarker levels in periodontitis and healthy individuals, up to 31 December 2024. Meta-analysis included biomarkers from ≥ 2 studies per biofluid, with sensitivity analysis performed and evidence certainty assessed using the GRADE tool.Results: Thirty-six studies were included in the systematic review, with 31 eligible for meta-analysis. Overall, 39 biomarkers were identified: 33 in blood, 14 in saliva, and 6 in GCF. A meta-analysis was conducted for 12 blood biomarkers, of which high-density lipoprotein (HDL) was significantly reduced, low-density lipoprotein (LDL) was higher in periodontitis (though LDL lost significance on sensitivity analysis), and the oxidative stress index (OSI) was significantly associated with periodontitis. No significant differences were observed for C-reactive protein (CRP), interleukin-1beta (IL-1ß), interleukin (IL)-6, N-terminal pro-B-type natriuretic peptide (NT-proBNP), monocyte chemoattractant protein-1 (MCP-1), and asymmetric dimethylarginine (ADMA). CRP was the only biomarker pooled for saliva and GCF, with no significant findings.Conclusion: Reduced blood HDL and elevated OSI represent potential cardiovascular biomarkers for periodontitis, although the certainty of evidence remains low.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Large Artificial Intelligence-Based Linguistic Models Help to Obtain Information About Burning Mouth Syndrome? 基于人工智能的大型语言模型能否帮助获取关于灼口综合征的信息？

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70078

Paula Benito López, Daniela Adamo, Vito Carlo Alberto Caponio, José González-Serrano, Alan Roger Dos Santos Silva, Miguel de Pedro Herráez, Rui Albuquerque, María Pía López Jornet, Vlaho Brailo, Arwa Farag, Márcio Diniz Freitas, Noburo Noma, Richeal Ni Riordain, Gonzalo Hernández, Rosa María López-Pintor

{"title":"Can Large Artificial Intelligence-Based Linguistic Models Help to Obtain Information About Burning Mouth Syndrome?","authors":"Paula Benito López, Daniela Adamo, Vito Carlo Alberto Caponio, José González-Serrano, Alan Roger Dos Santos Silva, Miguel de Pedro Herráez, Rui Albuquerque, María Pía López Jornet, Vlaho Brailo, Arwa Farag, Márcio Diniz Freitas, Noburo Noma, Richeal Ni Riordain, Gonzalo Hernández, Rosa María López-Pintor","doi":"10.1111/odi.70078","DOIUrl":"https://doi.org/10.1111/odi.70078","url":null,"abstract":"Objective: Burning Mouth Syndrome (BMS) is an idiopathic chronic orofacial pain disorder with diagnostic and therapeutic challenges. Inexperienced clinicians may desperately resort to online information. The objective of this study was to evaluate the usefulness, quality, and readability of responses generated by three artificial intelligence large language models (AI-LLMs)-ChatGPT-4, Gemini, and Microsoft Copilot-to frequent questions about BMS.Materials and methods: Nine clinically relevant open-ended questions were identified through search-trend analysis and expert review. Standardized prompts were submitted, and responses were independently rated by 12 international experts using a 4-point usefulness scale. Quality was evaluated using the QAMAI tool. Readability was measured using Flesch-Kincaid Grade Level and Reading Ease scores. Statistical analyses included Kruskal-Wallis and Bonferroni correction.Results: All AI-LLMs produced moderately useful responses, with no significant difference in global performance. Gemini achieved highest overall quality scores, particularly in relevance, completeness, and source provision. Copilot scored lower in usefulness and source provision. No significant differences were obtained among AI-LLMs. Average readability corresponded to 12th grade, with ChatGPT requiring the highest proficiency.Conclusions: AI-LLMs show potential for generating reliable information on BMS, though variability in quality, readability, and source citation remains concerning. Continuous optimization is essential to ensure their clinical integration.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotype-Phenotype Correlation in Fibrous Dysplasia/McCune-Albright Syndrome Patients With Craniofacial Lesions. 纤维结构不良/麦丘内-奥尔布赖特综合征伴颅面病变患者的基因型-表型相关性

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70074

Jiang Xue, Xuefen Li, Yanrui Feng, Lisha Sun, Tiejun Li

{"title":"Genotype-Phenotype Correlation in Fibrous Dysplasia/McCune-Albright Syndrome Patients With Craniofacial Lesions.","authors":"Jiang Xue, Xuefen Li, Yanrui Feng, Lisha Sun, Tiejun Li","doi":"10.1111/odi.70074","DOIUrl":"https://doi.org/10.1111/odi.70074","url":null,"abstract":"Objectives: We aimed to investigate genotype-phenotype correlations, variant prevalence, and prognostic factors in a Chinese cohort with craniofacial FD/MAS.Methods: A retrospective study of 93 histologically confirmed FD/MAS cases (2003-2024) analyzed GNAS mutations via direct sequencing. Clinical data, including disease onset, lesion activity (active vs. stable), and extraskeletal manifestations, were correlated with genotypic findings.Results: R201H was the predominant variant (58.1% vs. 41.9% R201C), with no significant differences in demographics, symptoms, or prognosis between genotypes. Active lesions (34.6%) exhibited earlier disease onset (8.0 vs. 12.0 years, p = 0.026), higher rates of bilateral involvement (51.9% vs. 27.5%, p = 0.033), pain (37.0% vs. 9.8%, p = 0.004), and nasal obstruction (25.9% vs. 2.0%, p = 0.003). MAS was strongly associated with active lesions (25.9% vs. 3.9%, p = 0.026), while monostotic FD predominated in stable lesions. All three cases of osteosarcoma harbored R201C; though statistical significance was not reached.Conclusions: This study showed no genotype-phenotype correlations in FD/MAS but highlights R201H as the major variant in this population. Active lesions correlate with early onset, bilateral craniofacial involvement, and MAS, warranting close monitoring. R201C's link to malignancy, though inconclusive, suggests possible variant-specific differences in malignant transformation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative Staging in Oral Cavity Cancer: Nationwide Practice and Concordance With Pathology. 口腔癌的术前分期：全国实践与病理一致。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70082

Hanneke Doremiek van Oorschot, Julie Maria Leonardus Sijmons, Jose Angelito Hardillo, Robert Jan Baatenburg de Jong

{"title":"Preoperative Staging in Oral Cavity Cancer: Nationwide Practice and Concordance With Pathology.","authors":"Hanneke Doremiek van Oorschot, Julie Maria Leonardus Sijmons, Jose Angelito Hardillo, Robert Jan Baatenburg de Jong","doi":"10.1111/odi.70082","DOIUrl":"https://doi.org/10.1111/odi.70082","url":null,"abstract":"Objectives: The clarity of TNM-classification for oral cancer has a direct impact on healthcare resource allocation, treatment decisions, morbidity, and clinical outcomes. However, possible TNM ambiguity between hospitals exists due to the broad range of available diagnostics. Therefore, this study aims to assess current practice variation in preoperative staging for oral cavity cancer.Materials and methods: All patients who underwent primary oral cavity cancer resection in the Netherlands between 2018 and 2021 were selected from the Dutch Head and Neck Audit database. Preoperative staging (cTN) was compared to definitive pathology staging (pTN) as the gold standard for assessing concordance at national and hospital levels.Results: Disease stage was upstaged in 27.5% of the patients. For T-classification analysis, 2458 patients were included. Accuracy for T-classification categories was 85.2%-93.1%, but significant hospital variation in overstaging and understaging was observed. For N-classification analysis, 1746 patients were included. Preoperative assessment of node involvement missed metastasis in 25.1% of the cN0 patients, resulting in 77.3% accuracy.Conclusion: Significant preoperative understaging of oral cancer calls the attention to the difficulties of the diagnostics of oral cancer. Although the accuracy of preoperative staging in oral cavity cancer is high, significant differences between hospitals were observed.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyst-Like Central Mucoepidermoid Carcinoma. 囊肿样中央黏液表皮样癌。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70077

Yige Liu, Jiannan Liu, Chunye Zhang, Jing Han

{"title":"Cyst-Like Central Mucoepidermoid Carcinoma.","authors":"Yige Liu, Jiannan Liu, Chunye Zhang, Jing Han","doi":"10.1111/odi.70077","DOIUrl":"https://doi.org/10.1111/odi.70077","url":null,"abstract":"Objective: Cyst-like central mucoepidermoid carcinoma (CC-MEC) is a special type of MEC in the jaw and clinically like a cyst. To analyze the clinicopathological features, treatment, and prognosis of CC-MEC.Methods: From 2018 to 2023, nine patients with CC-MEC who underwent surgery were retrospectively investigated.Results: Six females and three males, with a mean age of 43.1 (range, 10-75) years. Six in maxilla and three in mandible. Seven patients presented with painless swelling, two with pain and nasal congestion. The imaging findings were multilocular radiolucency lesions, with clear or unclear boundaries. Pathologically, six tumors had single or multiple cystic lesions with localized solid tumor cell nests. Only three tumors showed cystic-solid lesions with typical features of MEC. Eight tumors had MAML2 break-apart. Seven patients underwent fenestration or curettage, and five followed by radical surgery due to tumor recurrence. Two patients had radical resection during their initial operations. Postoperative outcomes were available for eight patients; no deaths and recurrence.Conclusion: CC-MEC in the jaw is prone to misdiagnosis as a jaw cyst. Final diagnosis often relies on MAML2 gene testing. Curettage has a high risk of recurrence. Complete resection leads to satisfactory outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Limosilactobacillus reuteri Probiotic on Oral Mucositis in Patients Undergoing Head and Neck Radiation: A Randomised Trial. 罗伊氏乳酸杆菌益生菌对头颈部放疗患者口腔黏膜炎的影响：一项随机试验。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-31 DOI: 10.1111/odi.70083

Charlene Enhui Goh, Rohan Williams, Nitasha Gupta, Francis Ho, Intekhab Islam, Clement Wei Ming Lai, Kai Soo Tan, Catherine Hsu Ling Hong

{"title":"Effect of Limosilactobacillus reuteri Probiotic on Oral Mucositis in Patients Undergoing Head and Neck Radiation: A Randomised Trial.","authors":"Charlene Enhui Goh, Rohan Williams, Nitasha Gupta, Francis Ho, Intekhab Islam, Clement Wei Ming Lai, Kai Soo Tan, Catherine Hsu Ling Hong","doi":"10.1111/odi.70083","DOIUrl":"https://doi.org/10.1111/odi.70083","url":null,"abstract":"Objective: Limited management strategies exist for cancer therapy-induced oral mucositis (OM).Materials and methods: We conducted a randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of Limosilactobacillus reuteri (LR) probiotic to prevent and reduce the severity of OM in head and neck cancer patients undergoing radiotherapy (RT). Patients ≥ 21 years requiring head and neck RT of ≥ 60 Gy and those undergoing concurrent chemotherapy with RT (CCRT) with no prior OM were recruited. OM incidence and severity were assessed weekly from baseline to two weeks post-RT. Oral samples were collected at baseline and study mid-point to profile microbiome changes.Results: Overall, no significant differences in OM incidence or severity (grade ≥ 3) were observed between LR and placebo groups. However, subgroup analyses of participants who received RT-only showed significantly lower mean OM scores (-0.42; 95% CI: -0.75, -0.09; p = 0.02) over time in the LR probiotic group. Beta diversity of the oral microbiome was significantly different between the RT-only probiotic and placebo groups (PERMANOVA: F = 1.77; R2 = 0.07; p = 0.025). No serious adverse effects were observed in the LR group.Conclusion: LR probiotic use was safe and associated with a reduced OM incidence and severity in RT-only participants. These findings are promising and provide important insights for future studies in larger cohorts.Trial registration: ClinicalTrials.gov: NCT03552458.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PKM2's Dual Role in Periodontitis: Regulating Inflammation and Bone Metabolism Imbalance. PKM2在牙周炎中的双重作用：调节炎症和骨代谢失衡。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-24 DOI: 10.1111/odi.70075

Han Gao

{"title":"PKM2's Dual Role in Periodontitis: Regulating Inflammation and Bone Metabolism Imbalance.","authors":"Han Gao","doi":"10.1111/odi.70075","DOIUrl":"https://doi.org/10.1111/odi.70075","url":null,"abstract":"Objective: Given the recognized importance of pyruvate kinase M2 isoform (PKM2) in immunometabolism and periodontitis, yet a lack of synthesis on its dual metabolic and non-metabolic functions across key periodontal cell types, this short review aims to explore the central mechanisms by which PKM2 drives sustained inflammation and bone metabolic imbalance. It examines its role as a molecular hub linking \"metabolism-immune-bone destruction\" to provide insights into disease mechanisms and targeted therapies.Subjects and methods: The review integrates recent advances in immunometabolism and periodontitis research. Through comprehensive analysis of PKM2's dual \"metabolic and non-metabolic\" roles in macrophage polarization, T-cell subset regulation, neutrophil function, and bone metabolism, its molecular network mediating host immune dysregulation and tissue destruction is revealed.Results: PKM2 activates glycolysis to promote M1 macrophage polarization and enhance pro-inflammatory cytokine release. PKM2 induces T-cell subset imbalance (Th17/Treg dysregulation), exacerbating inflammatory responses. PKM2 mediates neutrophil oxidative stress damage, amplifying local tissue destruction. PKM2 drives alveolar bone resorption by regulating osteoclast differentiation and osteoblast dysfunction.Conclusion: As a core hub connecting microbial dysbiosis, host metabolic reprogramming, and pathological outcomes, PKM2's dual functional properties offer a novel therapeutic target for periodontitis beyond conventional antimicrobial/anti-inflammatory strategies. Targeting PKM2 or its downstream metabolic-immune crosstalk may represent a breakthrough for halting disease progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Burning Mouth Syndrome in Parkinson's Disease: A Prospective Case-Control Study. 帕金森病患者灼口综合征的患病率：一项前瞻性病例对照研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-18 DOI: 10.1111/odi.70069

Anne Mishellany-Dutour, Céline Melin, Ingrid De Chazeron, Frank Durif, Radhouane Dallel, Christelle Gremeau-Richard

{"title":"Prevalence of Burning Mouth Syndrome in Parkinson's Disease: A Prospective Case-Control Study.","authors":"Anne Mishellany-Dutour, Céline Melin, Ingrid De Chazeron, Frank Durif, Radhouane Dallel, Christelle Gremeau-Richard","doi":"10.1111/odi.70069","DOIUrl":"10.1111/odi.70069","url":null,"abstract":"Objective: To determine the prevalence of Burning mouth syndrome (BMS) in patients with Parkinson's disease (PD) and compare it with an age- and sex-matched control group.Methods: The study included 150 PD patients and 150 age- and sex-matched control subjects. Participants were asked about any possible burning or tingling sensation in the oral mucosa. Those who responded positively underwent a clinical examination and blood analysis to help in diagnosing BMS.Results: Prior to clinical examination, the prevalence of probable BMS was 6.7% (10/150) in PD patients and 2% (3/150) in the control group. After the clinical examination, 6 participants were excluded (3 from each group), resulting in a BMS prevalence of 4.7% in the PD group (7/150) and 0% in the control group (0/150). The difference in prevalence between the two groups was statistically significant (p = 0.015). Patients reported that their BMS symptoms began either after or around the time of their PD diagnosis.Conclusions: BMS is more prevalent in PD patients than in the general population, indicating a potential role of dopaminergic system dysfunction in BMS pathophysiology. The onset of BMS symptoms after or around the time of PD diagnosis suggests that BMS may be a secondary condition.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Vesicles of Salivary Adenoid Cystic Carcinoma Suppress Immune Microenvironment in Lung. 涎腺样囊性癌细胞外囊泡抑制肺免疫微环境。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70065

Yue Lou, Longping Liu, Yuping Liu, Zheng Zhou, Lijing Zhu, Yajuan Cui, Huaxiu Sun, Xuan Zhou, Chuanxiang Zhou, Tiejun Li

{"title":"Extracellular Vesicles of Salivary Adenoid Cystic Carcinoma Suppress Immune Microenvironment in Lung.","authors":"Yue Lou, Longping Liu, Yuping Liu, Zheng Zhou, Lijing Zhu, Yajuan Cui, Huaxiu Sun, Xuan Zhou, Chuanxiang Zhou, Tiejun Li","doi":"10.1111/odi.70065","DOIUrl":"https://doi.org/10.1111/odi.70065","url":null,"abstract":"Objective: Salivary adenoid cystic carcinoma (SACC) frequently metastasizes to the lung and affects patient survival. Extracellular vesicles (EVs) have significant effects in the tumor pre-metastatic niche (PMN). In this study, we aimed to investigate immune changes in the lung pre-metastatic microenvironment of SACC.Methods: A pre-metastatic microenvironment was established using SACC-derived EVs at different time points. Labeled EVs were injected into mice to examine their different organ distributions. Flow cytometry was conducted to analyze the immune cell populations. In vitro, the same amount of SACC-derived EVs or EV-depleted conditional medium was added to macrophages to stimulate polarization.Results: The SACC-derived EVs colonized mostly in the lung and were engulfed by lung interstitial macrophages (IM). At different time points, the SACC-derived EVs induced decreased total macrophage, natural killer cell, and T cell populations, especially CD8+ T cells. They also increased the M2 macrophage composition and regulatory T cell population. The in vitro study showed that SACC-derived EVs induce a mixed M1/M2 phenotype, but this effect was eliminated with the EV-depleted media.Conclusions: SACC-derived EVs circulate to the lung, where they are engulfed by IM and induce an immunosuppressive environment. In vitro experiments revealed that cargos on EVs could mediate macrophage polarization.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0