Oral diseases最新文献_第4页

Diagnostic Performance of ChatGPT-4o and DeepSeek-3 Differential Diagnosis of Complex Oral Lesions: A Multimodal Imaging and Case Difficulty Analysis. chatgpt - 40和DeepSeek-3鉴别诊断复杂口腔病变的诊断性能：多模态成像和病例难度分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-07-01 DOI: 10.1111/odi.70007

Fatma E A Hassanein, Ahmed El Barbary, Radwa R Hussein, Yousra Ahmed, Jylan El-Guindy, Susan Sarhan, Asmaa Abou-Bakr

{"title":"Diagnostic Performance of ChatGPT-4o and DeepSeek-3 Differential Diagnosis of Complex Oral Lesions: A Multimodal Imaging and Case Difficulty Analysis.","authors":"Fatma E A Hassanein, Ahmed El Barbary, Radwa R Hussein, Yousra Ahmed, Jylan El-Guindy, Susan Sarhan, Asmaa Abou-Bakr","doi":"10.1111/odi.70007","DOIUrl":"https://doi.org/10.1111/odi.70007","url":null,"abstract":"Background: AI models like ChatGPT-4o and DeepSeek-3 show diagnostic promise, but their reliability in complex, image-based oral lesions remains unclear. This study aimed to evaluate and compare the diagnostic accuracy of ChatGPT-4o and DeepSeek-3 despite their differing modalities against oral medicine (OM) experts across varied lesion types and case difficulty levels.Methods: Eighty standardized clinical vignettes derived from real-world oral disease cases, including clinical images/radiographs, were evaluated. Differential diagnoses were generated by ChatGPT-4o, DeepSeek-3, and four board-certified OM specialists, with accuracy assessed at Top-1, Top-3, and Top-5 levels.Results: OM specialists consistently achieved the highest diagnostic accuracy. However, DeepSeek-3 significantly outperformed ChatGPT-4o at the Top-3 level (p = 0.0153) and showed greater robustness in high-difficulty and inflammatory cases despite its text-only modality. Multimodal imaging enhanced diagnostic accuracy. Regression analysis indicated lesion type and imaging modality as positive predictors, while diagnostic difficulty negatively impacted Top-1 performance.Conclusions: Remarkably, the text-only DeepSeek-3 model exceeded the diagnostic performance of the multimodal ChatGPT-4o model for complex oral lesions, highlighting its structured reasoning capabilities and reduced hallucination rate. These findings underscore the potential of non-vision LLMs in diagnostic support, emphasizing the critical need for expert oversight in complex scenarios.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Lesions in a Patient With Hodgkin's Lymphoma. 霍奇金淋巴瘤患者的口腔病变。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-27 DOI: 10.1111/odi.15327

Breno Amaral Rocha, Gianne Donato Costa Veloso, Christine Mendes Silveira, Polianne Alves Mendes, Giovanna Ribeiro Souto, Soraya de Mattos Camargo Grossmann, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta

引用次数: 0

Current Evidence on the Effects of Ozone Therapy on Bone Repair in Animal Models Treated With Zoledronic Acid: State of the Art. 臭氧治疗对唑来膦酸治疗动物模型骨修复作用的最新证据：最新进展。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-26 DOI: 10.1111/odi.70016

Mateus Torres-Silva, Maísa Pereira-Silva, Maria Eduarda de Freitas Santana Oliveira, Henrique Hadad, Pier Paolo Poli, Sérgio Bruzadelli Macedo, Celso Fernando Palmieri Junior, Francisley Ávila Souza

引用次数: 0

How Gender Shapes the Hyperuricemia-Periodontitis Crossroads. 性别如何塑造高尿酸血症-牙周炎的十字路口。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-26 DOI: 10.1111/odi.15338

Caixiu Yang, Dongmei Meng, Shuo Xu, Li Zhang, Yanwen Wang, Qunli Guan, Zhaoyu Lu, Liru Zhu, Shuyu Ge, Xiangguo Yin, Qiuxia Ji

引用次数: 0

The Eye of Horus: Enhancing Head and Neck Cancer Care with Computer Vision. 荷鲁斯之眼：用计算机视觉增强头颈癌护理。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-26 DOI: 10.1111/odi.70013

Ke-Ru Shen, Lei-Ming Cao, Zi-Zhan Li, Guang-Rui Wang, Yao Xiao, Han-Yue Luo, Bing Liu, Lei Xi, Lin-Lin Bu

{"title":"The Eye of Horus: Enhancing Head and Neck Cancer Care with Computer Vision.","authors":"Ke-Ru Shen, Lei-Ming Cao, Zi-Zhan Li, Guang-Rui Wang, Yao Xiao, Han-Yue Luo, Bing Liu, Lei Xi, Lin-Lin Bu","doi":"10.1111/odi.70013","DOIUrl":"https://doi.org/10.1111/odi.70013","url":null,"abstract":"Background: Head and neck cancer (HNC) poses formidable treatment challenges globally due to complex anatomy, image interpretation difficulties, and other obstacles, despite extensive research. Recent advancements in artificial intelligence (AI), particularly computer vision (CV), have demonstrated substantial potential in improving HNC management, yielding notable progress.Methods: We conducted a narrative review through massive literature research to explore the applications of CV in HNC and try to discuss its advantages as well as disadvantages through comparison.Results: We summarize the applications and cutting-edge advances of CV in prevention, diagnosis, treatment, and prognosis prediction in HNC, synthesize the concepts and workflow of CV and discuss the advantages and disadvantages of it. Additionally, we bridge the gap among healthcare professionals and AI researchers to promote the development of relevant fields jointly.Conclusions: CV holds great promise in HNC. We should continually deepen cooperation and exchanges among healthcare professionals and AI researchers, thereby fostering the continuous development of CV in the treatment of HNC. With the continuous optimization of algorithms, the application of CV in HNC will become even more extensive.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Cell-Free DNA Concentration as a Biomarker in Head and Neck Cancer. 循环游离细胞DNA浓度作为头颈癌的生物标志物。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-26 DOI: 10.1111/odi.70002

Ana María Rodríguez-Ces, Óscar Rapado-González, Santiago Aguín-Losada, Inés Formoso-García, José Luís López-Cedrún, Gabriel Triana-Martínez, Rafael López-López, María Mercedes Suárez-Cunqueiro

{"title":"Circulating Cell-Free DNA Concentration as a Biomarker in Head and Neck Cancer.","authors":"Ana María Rodríguez-Ces, Óscar Rapado-González, Santiago Aguín-Losada, Inés Formoso-García, José Luís López-Cedrún, Gabriel Triana-Martínez, Rafael López-López, María Mercedes Suárez-Cunqueiro","doi":"10.1111/odi.70002","DOIUrl":"https://doi.org/10.1111/odi.70002","url":null,"abstract":"Objective: Head and neck squamous cell carcinoma (HNSCC), particularly human papillomavirus (HPV) -negative HNSCC, poses a significant clinical challenge due to late diagnoses and poor survival. This study evaluates the potential of circulating cell-free DNA (ccfDNA) as a minimally invasive biomarker for diagnosis, prognosis and disease monitoring in HNSCC.Methods: We conducted a multicentre, prospective study enrolling 85 patients across all disease stages and 28 healthy controls, using two quantification ccfDNA methods: fluorometry (Qubit) and quantitative real-time polymerase chain reaction (qPCR).Results: Baseline plasma ccfDNA concentrations were significantly elevated in HNSCC patients compared to healthy controls, with an area under the curve of 0.705. Higher ccfDNA levels were observed in early-stage HNSCC patients. While ccfDNA levels correlated with age, no significant associations were found with tumour stage or location. Patients with lower post-treatment ccfDNA levels demonstrated longer median progression-free survival (PFS) (16.37 months vs. 9.63 months, p < 0.05). Longitudinal analysis of locally advanced HNSCC revealed significant inter-patient variability in ccfDNA kinetics.Conclusions: Our study demonstrates the potential value of fluorometric ccfDNA quantification as a diagnostic, prognostic and monitoring biomarker for HNSCC. However, further well-designed studies must be carried out to enhance the clinical utility of ccfDNA as a biomarker for HNSCC management.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YAP Deficiency in Gli1⁺ Osteogenic Progenitors Leads to Condylar Hypoplasia via β-Catenin Signaling. Gli1+成骨祖细胞中YAP缺乏通过β-Catenin信号传导导致髁突发育不全。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-24 DOI: 10.1111/odi.70006

Yang Xiao, Yixin Li, Shuo Chen, Shiyang Feng, Mengnan Cao, Chenchen Gao, Kai-Yuan Fu, Jie Lei

{"title":"YAP Deficiency in Gli1+ Osteogenic Progenitors Leads to Condylar Hypoplasia via β-Catenin Signaling.","authors":"Yang Xiao, Yixin Li, Shuo Chen, Shiyang Feng, Mengnan Cao, Chenchen Gao, Kai-Yuan Fu, Jie Lei","doi":"10.1111/odi.70006","DOIUrl":"https://doi.org/10.1111/odi.70006","url":null,"abstract":"Objectives: The pathogenesis of mandibular condylar hypoplasia has not been fully understood. Our previous studies provided evidence that Gli1+ osteogenic progenitors contribute to condylar development. This study aimed to investigate the role of YAP in Gli1+ cells during condylar development.Methods: We generated Gli1-CreERT2;Yapfl/fl mice, in which tamoxifen (TMX) was used to induce the deletion of Yap in Gli1+ cells. CHIR injection was to activate β-catenin signaling. Microscopic photography, Micro-CT, hematoxylin-eosin (H&E) staining, immunofluorescence (IF) staining, Real-time quantitative polymerase chain reaction (RT-qPCR), tartrate-resistant acid phosphatase (TRAP) staining and calcein-alizarin red double labeling were conducted for analyses. Chromatin immunoprecipitation (ChIP) assay was used to investigate the molecular mechanism involved.Results: YAP co-localized with mandibular condylar Gli1+ osteogenic progenitors. After induction, Gli1-CreERT2;Yapfl/fl mice suffered from condylar hypoplasia characterized by reduced bone mass and impaired osteogenesis due to decreased cell proliferation. ChIP-qPCR analysis, RT-qPCR analysis, and immunofluorescence staining further proved that YAP could directly regulate the expression of β-catenin. Functionally, pharmacological activation of β-catenin signaling successfully alleviated condylar hypoplasia in Gli1-CreERT2;Yapfl/fl mice.Conclusions: Our study demonstrated that the YAP/β-catenin axis mediated osteogenesis in Gli1+ osteogenic progenitors during condylar development, which may provide a potential target for the treatment of condylar hypoplasia.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online Searches for Periodontitis and Smoking Cessation in Brazil: A Reflection of Socioeconomic Disparities. 在线搜索牙周炎和戒烟在巴西：社会经济差距的反映。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-22 DOI: 10.1111/odi.70008

Pedro Paulo de Almeida Dantas, Larissa Viana de Oliveira, Humberto Alexander Baca Juárez, Roberto Pereira Pimentel, Paulo Ricardo Martins-Filho, Francisco Wilker Mustafa Gomes Muniz

引用次数: 0

Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study. 肾移植患者唾液和血清细胞因子浓度：一项前瞻性研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-22 DOI: 10.1111/odi.70012

Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David-Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz-Silva, Fabiana Martins

{"title":"Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study.","authors":"Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David-Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz-Silva, Fabiana Martins","doi":"10.1111/odi.70012","DOIUrl":"https://doi.org/10.1111/odi.70012","url":null,"abstract":"Background: Kidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well-established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.Objective: To investigate salivary and serum cytokine levels in KTRs and their correlations with clinical outcomes over time.Materials and methods: We evaluated the same group of 38 KTRs at T1 (< 6 months post-transplantation) and T2 (> 6 months post-transplantation). Samples were analysed with Human 6-Plex Cytokine Panel (Luminex) and clinical data were collected from medical records. Statistical analyses included Wilcoxon tests, Fisher's exact tests, Spearman's correlation, and Benjamini-Hochberg procedure for multiple comparisons (p < 0.05 significant).Results: Serum cytokines showed lower IFN-γ levels in cardiac events and associations of TNF-α, IL-8, and IL-10 with cytomegalovirus (CMV), BK polyomavirus (BKPyV) viremia and anaemia. Salivary cytokines showed distinct profiles, with elevated levels of TNF-α in anaemia and IL-8 in patients with diarrhoea. Those not experiencing acute rejection in both cases showed reduced salivary IL-8 levels.Conclusions: Integrating serum and salivary measurements highlighted the potential of salivary biomarkers, particularly TNF-α and IL-8, in complementing traditional blood-based assays and other invasive monitoring methods in kidney transplantation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-22 DOI: 10.1111/odi.70014

Thayanara Silva Melo, Angela Luzia Branco Pinto Duarte, Mário Luciano de Mélo Silva Júnior, Luiz Alcino Gueiros

引用次数: 0