Oral diseases最新文献_第5页

Paediatric Oral and Maxillofacial Malignancies in Kenya and Malaysia. 肯尼亚和马来西亚的儿科口腔和颌面恶性肿瘤。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-23 DOI: 10.1111/odi.15392

Joseph Mutio, Krishan Sarna, Elizabeth A O Dimba, Wambeti Twahir, Wei Cheong Ngeow, Yet Ching Goh

引用次数: 0

Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis. 基质金属蛋白酶-8在牙周病诊断中的准确性：一项meta分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-23 DOI: 10.1111/odi.15389

Dong Zhang, Chao Xu, Mengmeng Liang, Wenting Shao, Peng Wang, Yahong Yang, Kangle Guo

{"title":"Diagnostic Accuracy of Matrix Metalloproteinase-8 for Detecting Periodontal Disease: A Meta-Analysis.","authors":"Dong Zhang, Chao Xu, Mengmeng Liang, Wenting Shao, Peng Wang, Yahong Yang, Kangle Guo","doi":"10.1111/odi.15389","DOIUrl":"https://doi.org/10.1111/odi.15389","url":null,"abstract":"Background: Matrix metalloproteinase-8 (MMP-8) serves as a biomarker for periodontal diseases; numerous studies have demonstrated its diagnostic accuracy in detecting both periodontitis and gingivitis.Methods: A comprehensive search was performed up to 25 March 2025. Observational studies investigating MMP-8's diagnostic potential for periodontal disease and gingivitis were included. Pooled sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated using Stata 15.1, with diagnostic accuracy measures reported as point estimates and 95% confidence intervals (CI).Results: The meta-analysis included 22 diagnostic studies encompassing 2492 participants. Pooled estimates demonstrated robust diagnostic performance of MMP-8 for periodontal disease, with sensitivity of 0.83 (95% CI: 0.78-0.87), specificity of 0.77 (95% CI: 0.71-0.83), and AUC of 0.87 (95% CI: 0.84-0.90). Subgroup analysis revealed superior accuracy of immunofluorometric assay (IFMA), showing higher sensitivity (0.88) and specificity (0.77) compared to enzyme-linked immunosorbent assay (ELISA, sensitivity/specificity = 0.84/0.76) and point-of-care testing (POCT, sensitivity/specificity = 0.73/0.64). Biological sample comparisons identified gingival crevicular fluid as the optimal source, achieving significantly higher diagnostic accuracy (AUC = 0.91) than mouth rinse (AUC = 0.89) or saliva (AUC = 0.76).Conclusion: Our findings demonstrated that MMP-8 serves as a robust diagnostic biomarker for both periodontitis and gingivitis, with detection methods-IFMA, ELISA, and POCT-showing context-dependent applicability across clinical settings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Contradiction of Innovation: Oral Biosensors for Everything but Oral Diseases. 创新的矛盾：口腔生物传感器的一切，但口腔疾病。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15393

Hichem Moulahoum, Faezeh Ghorbanizamani

引用次数: 0

Risk of Periodontitis in People With Atopic Dermatitis: Real-World Evidences. 特应性皮炎患者牙周炎的风险：真实世界的证据。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15387

Shih-Chi Yang, Hui-Chin Chang, Shiu-Jau Chen, Shuo-Yan Gau

引用次数: 0

Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates. 非人类灵长类动物实验性牙周炎的血管和内皮转录组变化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15385

L M Nguyen, O A Gonzalez, A Balian, S S Kirakodu, J L Ebersole

{"title":"Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates.","authors":"L M Nguyen, O A Gonzalez, A Balian, S S Kirakodu, J L Ebersole","doi":"10.1111/odi.15385","DOIUrl":"https://doi.org/10.1111/odi.15385","url":null,"abstract":"Objective: The molecular features of the alterations in the integrity and function of the periodontal vasculature associated with the initiation/progression of periodontal lesions have not been well elucidated.Methods: This study used a nonhuman primate model of experimental ligature-induced periodontitis across the lifespan to profile transcriptomic responses related to vasculature/endothelial cell biologic activities.Results: In healthy tissues, genes representing EGF receptor signaling, VEGF signaling, and angiogenesis pathways showed some age effects. Disease initiation and/or early progression led to major changes in expression and a large number of vascular/endothelial genes showed correlations across the age groups. Specific bacteria (e.g., Veillonellacease, P. gingivalis, Fusobacterium) were highly correlated with gene changes (e.g., CCL2, CXCL1, EDN2, OCLN, PLAT, SELL, TGFB2). Overall differential expression analytics identified that the disease process appeared as the major controlling factor regarding the vascular/endothelial cell transcriptome.Conclusions: This study supports that alterations in vascular/endothelial cell biologic processes are observed in healthy tissues across the lifespan, with more substantive changes occurring during periodontal disease initiation and early progression. The expression patterns supported critical changes arising in the vasculature of gingival tissues that would contribute to the persistent nature of the immunoinflammatory response in this disease.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial". 对“局部氟西尼特对口腔扁平苔藓演变的影响：随机对照临床试验”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-20 DOI: 10.1111/odi.15362

Jianqiu Jin

引用次数: 0

Effects of Public Disclosure of a Japanese Celebrity's Oral Cancer: Trends in Oral Cancer Diagnoses. 公开披露日本名人口腔癌的影响：口腔癌诊断的趋势。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-15 DOI: 10.1111/odi.15367

Shihoko Koyama, Takahiro Tabuchi, Kayo Nakata, Toshitaka Morishima, Shuji Uchida, Miki Ishibashi, Isao Miyashiro

{"title":"Effects of Public Disclosure of a Japanese Celebrity's Oral Cancer: Trends in Oral Cancer Diagnoses.","authors":"Shihoko Koyama, Takahiro Tabuchi, Kayo Nakata, Toshitaka Morishima, Shuji Uchida, Miki Ishibashi, Isao Miyashiro","doi":"10.1111/odi.15367","DOIUrl":"https://doi.org/10.1111/odi.15367","url":null,"abstract":"Objective: On February 19, 2019, Chiemi Hori, a renowned Japanese singer, publicly announced her diagnosis of stage IV tongue cancer. The news was widely reported by the Japanese media. This study examined the association between the celebrity's tongue cancer disclosure and trends in the number of oral cancer diagnoses in the national population-based cancer registry (NCR) in Japan.Methods: Data from the NCR were used to plot monthly changes in the number of oral cancer diagnoses from 2016 to 2019 according to sex, age, residential area (divided into five categories based on the density of dentists), cancer site, and clinical stage at initial treatment. Time trends were analyzed using Joinpoint regression.Results: Between 2016 and 2019, 39,415 oral cancer cases were registered. After Ms. Hori's disclosure, oral cancer diagnoses increased significantly, while other head and neck cancers showed no significant changes. The number of oral cancer diagnoses increased from 784 in January 2019 to 1195 in March 2019 (an average monthly change rate of 8.6% from December 2018 to March 2019).Conclusions: There has been a sharp increase in the number of oral cancer diagnoses since the celebrity's disclosure. This suggests that it has raised public awareness of oral cancer.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study. 术中ICG NIF成像定义MRONJ的手术切缘：一项前瞻性观察研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15384

Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, Chengwan Xia, Guowen Sun, Yumei Pu

{"title":"Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study.","authors":"Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, Chengwan Xia, Guowen Sun, Yumei Pu","doi":"10.1111/odi.15384","DOIUrl":"https://doi.org/10.1111/odi.15384","url":null,"abstract":"Background: This study explored the feasibility and effectiveness of indocyanine green (ICG)-based near-infrared fluorescence (NIF) imaging for localizing bone lesions associated with medication-related osteonecrosis of the jaw (MRONJ) during surgical intervention.Methods: A prospective observational study was conducted on 68 patients who underwent surgical treatment for MRONJ at a single institution between January 2021 and April 2024. Among them, 14 patients received surgery guided by NIF imaging, while the remaining patients underwent surgery without NIF guidance. Postoperative follow-up was performed to assess clinical outcomes.Results: There were no significant differences between the two groups regarding age, medication type and duration, underlying disease, lesion location, clinical stage, concomitant symptoms, or surgical approach. NIF imaging remained stable in 14 patients who underwent MRONJ fluorescence surgery. The recurrence rate was lower in the NIF group (14.29%) than in the non-NIF group (27.78%). The difference in the recurrence-free survival curves between the two groups was statistically significant (p = 0.043).Conclusion: ICG-mediated NIF imaging provides a reliable method for identifying MRONJ-related bone lesions and offers valuable intraoperative guidance, potentially improving surgical outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on "Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil". 对“头颈癌预后因素：巴西3052例患者回顾性队列研究”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15380

Efsun Somay

引用次数: 0

Classic Desmoplastic Ameloblastoma: Should It Be a Distinct Subtype of Ameloblastoma?-Based on Clinicopathological, Radiological, Immunohistochemical and Molecular Study of a Large Cohort. 典型的成釉细胞瘤：它应该是成釉细胞瘤的一个独特亚型吗？基于一个大队列的临床病理、放射学、免疫组织化学和分子研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-05-13 DOI: 10.1111/odi.15376

Xiaofeng Zheng, Ronghui Xia, Wenjing Zhu, Chuxiang Qu, Ting Gu, Liam Robinson, Willie van Heerden, Wanninayake Mudiyanselage Tilakaratne, Kelly Magliocca, Merva Soluk-Tekkesin, Akinyele Olumuyiwa Adisa, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Ronell Bologna-Molina, Ricardo Santiago Gomez, Keith David Hunter, Jiang Li

{"title":"Classic Desmoplastic Ameloblastoma: Should It Be a Distinct Subtype of Ameloblastoma?-Based on Clinicopathological, Radiological, Immunohistochemical and Molecular Study of a Large Cohort.","authors":"Xiaofeng Zheng, Ronghui Xia, Wenjing Zhu, Chuxiang Qu, Ting Gu, Liam Robinson, Willie van Heerden, Wanninayake Mudiyanselage Tilakaratne, Kelly Magliocca, Merva Soluk-Tekkesin, Akinyele Olumuyiwa Adisa, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Ronell Bologna-Molina, Ricardo Santiago Gomez, Keith David Hunter, Jiang Li","doi":"10.1111/odi.15376","DOIUrl":"https://doi.org/10.1111/odi.15376","url":null,"abstract":"Objectives: To identify whether the classic desmoplastic ameloblastoma (DA) is an independent subtype of ameloblastoma.Materials and methods: Eighty-six classic DA and 28 hybrid DA cases were retrieved, and available clinical, radiological, and histopathological data were collected. DNA from microdissected tumor tissues were utilized for BRAF V600E, SMOL412F, and CTNNB1 mutation detection. Data of classic DA and hybrid DA were analyzed and compared with each other and with previous reports of conventional ameloblastoma (CA).Results: 69.8% (60/86) of classic DA occurred in the mandible, with the majority affecting the anterior-premolar regions. They were characterized as osteolytic bone expansion (33.8 ± 12.8 mm) with internal bone/calcification (57/58, 98.3%) in radiology. Genetically, classic DA exhibited a high incidence of BRAF V600E mutation (58/62, 93.5%) but no CTNNB1 and SMO L412F mutations. Hybrid DA exhibited similarities to CA in jawbone location, tumor size, and radiology. The recurrence rate of classic DA (9.2%) was lower than that of CA (25.8%).Conclusion: High anterior-premolar distribution, a mixture of osteolytic and internal high-density shadows in radiology, smaller tumor size, compressed epithelium with abundant stroma and scattered bone, consistent mutation of BRAF V600E, and better prognosis all suggest that classic DA may be a distinct clinicopathological subtype of ameloblastoma.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0