Oral diseases最新文献_第5页

CCL19⁺ Fibroblasts Promote Tertiary Lymphoid Structure in Oral Lichen Planus: A Retrospective Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15266

Yi-Rao Lai, Lei Pan, Xin-Ke Jiang, Yi-Wen Deng, Ming-Hua Feng, Jin Li, Xiao-Zhe Han, Lei Sun, Yu-Feng Wang, Guo-Yao Tang

{"title":"CCL19+ Fibroblasts Promote Tertiary Lymphoid Structure in Oral Lichen Planus: A Retrospective Study.","authors":"Yi-Rao Lai, Lei Pan, Xin-Ke Jiang, Yi-Wen Deng, Ming-Hua Feng, Jin Li, Xiao-Zhe Han, Lei Sun, Yu-Feng Wang, Guo-Yao Tang","doi":"10.1111/odi.15266","DOIUrl":"https://doi.org/10.1111/odi.15266","url":null,"abstract":"Objectives: The priming mechanism of adaptive immunity in oral mucositis remains unclarified. This study aimed to elucidate the mechanisms of oral lichen planus (OLP), with a specific focus on the role of inducible tertiary lymphoid structures (iTLSs) and stromal-immune microenvironments within OLP.Materials and methods: We employed single-cell RNA sequencing and multiplex immunofluorescence staining to characterize the spatial characteristics and transcriptional signature of iTLSs in OLP. To investigate whether the presence of iTLSs influences the disease severity of OLP, we retrospectively collected clinical data from OLP patients.Results: Based on single-cell resolution analysis, we identified distinct cellular compositions and fibroblast-immune cells interactions within the iTLSs of OLP. We highlighted the critical role of CCL19+ fibroblasts in T-cell chemotaxis, promoting the development of iTLSs. Lymphotoxin was demonstrated to activate fibroblasts expressing CCL19. We revealed a significant correlation between the presence of iTLSs and increased severity of OLP, marked by more atrophic-erosive forms and higher disease scores in patients with iTLSs.Conclusions: The present research proposed the fibroblast-immune cell interactions within iTLSs as essential factors in OLP's inflammatory milieu, indicating iTLSs as the priming structure of T-cell immunity in the local oral mucosa.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Modified Intrabony Defect Model of Periodontitis in Rat.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15284

Pei Cao, Chen-Hao Yu, Yuan-Qing Liu, Liang Chen, Qing-Xian Luan, Jia Liu

{"title":"A Modified Intrabony Defect Model of Periodontitis in Rat.","authors":"Pei Cao, Chen-Hao Yu, Yuan-Qing Liu, Liang Chen, Qing-Xian Luan, Jia Liu","doi":"10.1111/odi.15284","DOIUrl":"https://doi.org/10.1111/odi.15284","url":null,"abstract":"Objective: The aim of this study was to compare the radiographic depth of the periodontal bone defect, as well as clinical and histological outcomes, between the proposed ligated defect model and the current non-ligated defect model, which often heals spontaneously and fails to replicate the complexities of periodontitis.Methods: The proposed model combined osteotomy to create controlled periodontal bone defects (depth of 1.5 mm) and ligature placement around the cervical region of the maxillary first molar to induce inflammation. Micro-CT analysis, clinical examinations, histological evaluations, and quantitative PCR were conducted to assess defect morphology, healing, and inflammatory marker expression over 6 weeks, compared with the non-ligated defect group, sham surgery group, and control.Results: Bone defect in the ligated defect group remained unhealed after surgery (1.525 ± 0.068 mm in depth at 2 weeks and 1.543 ± 0.082 mm at 6 weeks), with inflammatory cell infiltration and elevated expression of IL-1β, IL-6, and TNF-α, contrasting with observed healing from 1.328 ± 0.075 mm (2 weeks) to 0.593 ± 0.118 mm (6 weeks) in the non-ligated defect group.Conclusions: This model not only simulates the pathological features of periodontitis but also provides a reliable platform for testing innovative regenerative strategies and could lead to the development of specialized models for other periodontal conditions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Contaminated/Misidentified Cell Lines: A Critical Concern for Oral Cancer Research.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15295

Pedro Henrique Sette-de-Souza, Moan Jéfter Fernandes Costa

引用次数: 0

Real-World Study of Later-Line Anlotinib in R/M Head and Neck Squamous Cell Carcinoma.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15290

Houyu Ju, Yuanyuan Zhao, Minqi Zhao, Lingyan Chen, Xinrong Geng, Xuanli Xu, Guoxin Ren, Jingzhou Hu

{"title":"Real-World Study of Later-Line Anlotinib in R/M Head and Neck Squamous Cell Carcinoma.","authors":"Houyu Ju, Yuanyuan Zhao, Minqi Zhao, Lingyan Chen, Xinrong Geng, Xuanli Xu, Guoxin Ren, Jingzhou Hu","doi":"10.1111/odi.15290","DOIUrl":"https://doi.org/10.1111/odi.15290","url":null,"abstract":"Objectives: The option is rare for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) failed to prior-line immune checkpoint inhibitors (ICIs) and cetuximab-based treatment. The efficacy of salvage therapy was unsatisfied.Materials and methods: We collected the clinical data of R/M HNSCC patients progressed from prior-line immunotherapy and cetuximab therapy, and retrospectively analyzed the efficacy and toxicity of anlotinib-based therapy in these patients.Results: In total, 24 eligible participants were accrued between October 2021 and November 2024. Up to the cutoff time of November 1st, 2024, the objective response rate was 37.5%. Survival analysis revealed the median progression-free survival and overall survival was 4.27 months (95% CI, 1.53-7.01 months) and 8.67 months (95% CI, 5.62-11.72 months), respectively. For the safety, most common TRAEs with any grades were hypertension, hand-foot syndrome, gastrointestinal response, hemorrhage, hepatic dysfunction, and fatigue. Grade 3 or more TRAEs were observed in 3 (12.5%) patients, and no Grade 5 TRAEs were occurred.Conclusions: Our observations indicated that anlotinib-based therapy had considerable efficacy and well tolerance in R/M HNSCC patients failed to ICIs and cetuximab-based therapy, and might be acted as a novel and potentially effective option in later-line treatment of R/M HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15260

Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye

{"title":"Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye","doi":"10.1111/odi.15260","DOIUrl":"https://doi.org/10.1111/odi.15260","url":null,"abstract":"Background: Despite evidence suggesting a potential correlation between intestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) with periodontitis (PD), there is a lack of comprehensive systematic reviews and meta-analyses to consolidate these findings.Methods: This study investigates studies published until December 31, 2023, in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. The statistical analysis was conducted using Review Manager Version 5.4, calculating odds ratios (OR) and 95% confidence intervals (CI) based on the selected research papers, utilizing a fixed-effects model.Results: It demonstrates a significant increase in the risk of PD among patients with IBD, as indicated by an OR of 2.11 (95% CI: 1.80-2.49). Further analysis revealed elevated risks of PD for both Crohn's disease (CD) and ulcerative colitis (UC), with respective ORs of 1.96 (95% CI: 1.69-2.26) and 2.14 (95% CI: 1.85-2.47). A direct association was observed between CRC and PD, suggesting a 20% higher risk of PD in patients with CRC (OR = 1.20, 95% CI: 1.06-1.36).Conclusion: Our meta-analysis highlights the potential role of PD in managing systemic conditions like IBD and CRC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15281

Mohit Kothari, Silas Alves-Costa, Abhishek Kumar, Gustavo G Nascimento, Jørgen Feldbæk Nielsen, Peter Svensson, Simple F Kothari

{"title":"Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.","authors":"Mohit Kothari, Silas Alves-Costa, Abhishek Kumar, Gustavo G Nascimento, Jørgen Feldbæk Nielsen, Peter Svensson, Simple F Kothari","doi":"10.1111/odi.15281","DOIUrl":"https://doi.org/10.1111/odi.15281","url":null,"abstract":"Objectives: To evaluate the presence, severity and progression of temporomandibular disorders (TMD) in acquired brain injury (ABI) population and determine the diagnostic accuracy of 3Q/TMD and Fonseca Anamnestic Index (FAI) against the gold standard, Diagnostic Criteria for TMD (DC/TMD).Methods: ABI individuals were assessed using 3Q/TMD and FAI at admission (n = 73) and Week 4 (n = 52), while DC/TMD was conducted only at Week 4. Diagnostic accuracy, sensitivity and specificity of 3Q/TMD and FAI were calculated against DC/TMD.Results: TMD was detected in 66.0% (3Q/TMD) and 27.8% (FAI) at admission, with mild (75%) to moderate (25%) severity which was mostly pain-related. TMD frequency decreased to 11.3% (3Q/TMD) and 17.3% (FAI) by Week 4. Accuracy rates were 0.82 for 3Q/TMD and 0.83 for FAI. Sensitivity was 0.33 (3Q/TMD) and 0.50 (FAI), while specificity was high at 0.93 (3Q/TMD) and 0.90 (FAI).Conclusions: TMD presence was higher in an ABI population compared to the general population however the frequency decreased over time. The high specificity and accuracy of 3Q/TMD and FAI indicate their potentials as screening tools but their low sensitivity limits their effectiveness in identifying all TMD cases. Patients with ABI should be assessed for TMD as part of their comprehensive care.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attitude of Undergraduate Dental Students to Oral Mucosal Biopsies From Six European Countries.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15274

Vlaho Brailo, Božana Lončar Brzak, Barbara Carey, Ana Andabak Rogulj, Danica Vidović Juras, Ivana Škrinjar, Marcio Diniz Freitas, Jacobo Limeres Posse, Luis Monteiro, Luis M Silva, Jean-Cristophe Fricain, Sylvain Catros, Giovanni Lodi, Niccolò Lombardi, Elena Varoni, Richard Cook, Michael Escudier, Raj Ariyaratnam, Rui Albuquerque

{"title":"Attitude of Undergraduate Dental Students to Oral Mucosal Biopsies From Six European Countries.","authors":"Vlaho Brailo, Božana Lončar Brzak, Barbara Carey, Ana Andabak Rogulj, Danica Vidović Juras, Ivana Škrinjar, Marcio Diniz Freitas, Jacobo Limeres Posse, Luis Monteiro, Luis M Silva, Jean-Cristophe Fricain, Sylvain Catros, Giovanni Lodi, Niccolò Lombardi, Elena Varoni, Richard Cook, Michael Escudier, Raj Ariyaratnam, Rui Albuquerque","doi":"10.1111/odi.15274","DOIUrl":"https://doi.org/10.1111/odi.15274","url":null,"abstract":"Introduction: Multiple studies have been undertaken to assess level of knowledge on the topic of oral mucosal biopsies from a general dental practitioner perspective, but only limited data is available on undergraduate dental students' perspective. The aim of this study was to assess clinical experience and attitudes towards oral mucosal biopsies in final-year undergraduate dental students.Material and methods: Online questionnaire was sent to dental students in six European countries (Croatia, France, Italy, Portugal, Spain and United Kingdom). The questionnaire assessed clinical experience, attitudes to oral biopsy, self-perceived competence, and obstacles for performing a biopsy. Multiple choice questions and 5-point Likert scale were used.Results: Two hundred and ninety-three students (response rate 24% to 88%) participated in the survey. A small proportion of students (54; 21.7%) performed a biopsy during their undergraduate education, mainly in an oral medicine setting. The majority of students did not consider themselves competent in performing a biopsy. The most common listed obstacle for performing a biopsy was lack of clinical experience with oral mucosal lesions.Conclusion: The results suggest there is a need for more practical training in oral biopsy techniques, as well as a need for increased clinical exposure to different oral mucosal pathologies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitophagy and Its Significance in Periodontal Disease.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15279

Guliqihere Abulaiti, Xu Qin, Lili Chen, Guangxun Zhu

{"title":"Mitophagy and Its Significance in Periodontal Disease.","authors":"Guliqihere Abulaiti, Xu Qin, Lili Chen, Guangxun Zhu","doi":"10.1111/odi.15279","DOIUrl":"https://doi.org/10.1111/odi.15279","url":null,"abstract":"Objectives: Periodontal disease is a common chronic inflammatory condition affecting the tissues that support teeth, leading to their destruction. Mitophagy, a specialized form of autophagy responsible for degrading damaged mitochondria, plays a crucial role in maintaining cellular homeostasis. However, its role in periodontal disease progression remains poorly understood. This review aims to summarize recent research on mitophagy's role in periodontal disease pathogenesis.Methods: A comprehensive literature review on mitophagy was conducted using PubMed, Scopus, and Web of Science databases, employing keywords related to periodontal disease such as \"periodontal,\" \"periodontitis,\" \"gingiva,\" and \"gingivitis.\"Results: A review of 18 original studies revealed that mitophagy plays a crucial role in periodontal disease by regulating key pathophysiological mechanisms. Specifically, mitophagy modulates periodontal inflammation by influencing pro-inflammatory cytokines and mitochondrial reactive oxygen species. Additionally, it is essential for alveolar bone remodeling, impacting both bone resorption and regeneration. Mitophagy also regulates cell apoptosis within periodontal tissues, helping to preserve cellular function and tissue integrity during periodontal disease progression.Conclusions: Mitophagy regulates periodontal disease pathogenesis by modulating inflammation, bone remodeling, and cell death in periodontal tissues. Further research is needed to explore its therapeutic potential in periodontal disease treatment and improve targeted interventions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Family Medicine Residents' Competency to Manage Oral Lesions: An Educational Intervention.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15277

Çetin Batuhan Öçbe, Melisa Öçbe, Mehmet Akman

引用次数: 0

Exploring Cancer-Associated Fibroblasts in OSCC and OPMDs: Microenvironment Insights. Scoping Review.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15275

Samuele Sutera, Olga Anna Furchì, Monica Pentenero

{"title":"Exploring Cancer-Associated Fibroblasts in OSCC and OPMDs: Microenvironment Insights. Scoping Review.","authors":"Samuele Sutera, Olga Anna Furchì, Monica Pentenero","doi":"10.1111/odi.15275","DOIUrl":"https://doi.org/10.1111/odi.15275","url":null,"abstract":"Introduction: The tumor microenvironment (TME) plays a crucial role in oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). Despite progress, the mechanisms behind the TME-epithelial cell interaction remain unclear. Cancer-associated fibroblasts (CAFs), the most abundant cells in the TME, require further study.Material and methods: We conducted a scoping review, searching for clinical and vivo studies that discuss the role of CAFs in OSCC and OPMDs progression.Results: From 1152 PubMed results, 29 studies met the inclusion criteria. CAFs, identified as αSMA+ cells, interact with the TME and epithelial cells by secreting various molecules. In OSCC, CAF signals contribute to a pro-tumorigenic environment, and CAF numbers positively correlate with tumor grade, size, stage, aggressiveness, and mortality. While limited data exist on CAFs in OPMDs, they seem linked to malignant transformation risk.Discussion: CAFs are critical in OSCC pathophysiology, but the complex intercellular mechanisms are not fully understood. Currently, CAFs are not part of clinical decision-making, but emerging evidence suggests they could represent a promising new approach in managing OSCC and OPMDs.Conclusion: Future research should aim to gain a deeper understanding of how CAFs contribute to OSCC progression and their role in OPMDs pathophysiology.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0