Oral diseases最新文献_第5页

Piezo1 Modulates Synovial Macrophage Function to Influence the Progression of TMJ Arthritis. Piezo1调节滑膜巨噬细胞功能影响TMJ关节炎的进展。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70050

Lihang Shen, Ruiliu Li, Yifei Wang, Shuo Chen, Yang He

{"title":"Piezo1 Modulates Synovial Macrophage Function to Influence the Progression of TMJ Arthritis.","authors":"Lihang Shen, Ruiliu Li, Yifei Wang, Shuo Chen, Yang He","doi":"10.1111/odi.70050","DOIUrl":"https://doi.org/10.1111/odi.70050","url":null,"abstract":"Objectives: Synovial macrophages are pivotal regulators of the immune response in temporomandibular joint (TMJ) arthritis. This study investigates Piezo's regulatory effects on macrophage polarization and function in TMJ arthritis progression.Methods: A complete Freund's adjuvant (CFA) induced TMJ arthritis model was established in C57BL/6JNifdc mice, with saline as control. The treated group received Piezo1 inhibitor GsMTx4. Synovitis severity, cartilage degradation, and bone resorption were evaluated by morphological and radiological analyses. Macrophage infiltration, Piezo1, and inflammatory cytokines were analyzed via immunohistochemistry and immunofluorescence. WB and qPCR were used to study signaling pathways in bone marrow-derived macrophages (BMDMs) treated with Piezo1 siRNA, GsMTx4, and Yoda1.Results: Compared to the Saline group, the CFA group exhibited significant infiltration of pro-inflammatory macrophages and prominent osteochondral lesions. Furthermore, IF revealed co-localization of Piezo1, MMP13, MMP3, and TNFα with CD86+ macrophages. In vitro studies demonstrated that Piezo1 activates pro-inflammatory macrophages through the NF-κB pathway, whereas it suppresses anti-inflammatory macrophage polarization by inhibiting the STAT6 pathway. GsMTx4 treatment notably alleviated arthritis symptoms.Conclusions: The disturbed balance between pro-inflammatory and anti-inflammatory macrophages in synovitis may contribute to TMJ arthritis progression. Piezo1 modulates macrophage transcriptional regulation and polarization, influencing immune responses within the synovial environment and offering a potential therapeutic target for TMJ arthritis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Adverse Drug Events in Patients With Psoriasis Receiving Immunosuppressive Therapy: A Multicenter Cohort Study. 接受免疫抑制治疗的银屑病患者口服药物不良事件：一项多中心队列研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70067

Matthew H Lanehart, Zachary Zinn

引用次数: 0

Authors' Reply "Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial". 作者回复“局部氟西尼特对口腔扁平苔藓演变的影响：随机对照临床试验”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70070

Alessandro Polizzi, Gianluca Martino Tartaglia, Simona Santonocito, Angela Alibrandi, Anna Elisa Verzì, Gaetano Isola

引用次数: 0

Authors' Reply "Diagnostic Performance of Multimodal Large Language Models in the Analysis of Oral Pathology". 作者回复“多模态大语言模型在口腔病理分析中的诊断性能”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70071

Ana Suárez, Yolanda Freire, María Suárez, Víctor Díaz-Flores García, Cristina Andreu-Vázquez, Israel John Thuissard Vasallo, Ana Isabel Castillo Varón, Carmen Martín

引用次数: 0

A Silent Oral Health Crisis: Periodontal Disease Among Tea Plantation Workers in India. 无声的口腔健康危机：印度茶园工人的牙周病。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70066

Delfin Lovelina Francis, Saravanan Sampoornam Pape Reddy

引用次数: 0

Authors' Reply "Recurrent Aphthous Stomatitis and Sleep Quality Factors: A Comprehensive Analysis". 作者回复“复发性口腔炎与睡眠质量因素的综合分析”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70073

Sina Bazmi, Zahra Mohammadi, Reza Tabrizi, Maryam Kazemi

引用次数: 0

Space Dentistry Combined With Remote and AI Technologies, a Necessity for Long-Term Stays: Thoughts of US Astronauts' Unexpected Stay. 太空牙科与远程和人工智能技术相结合，是长期停留的必需品：对美国宇航员意外停留的思考。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70054

Xufeng Huang, Zhengrui Li, Qi Wang, Ji'an Liu, Ge Zhang, Runzhi Chen, Xuefan Bu, Yixi Wang, Peng Luo, Ling Zhang, Andras Hajdu

引用次数: 0

Comment on "Recurrent Aphthous Stomatitis and Sleep Quality Factors: A Comprehensive Analysis". 《复发性口腔炎与睡眠质量因素综合分析》述评

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-16 DOI: 10.1111/odi.70068

Xin Li, Yanchun Zhang

引用次数: 0

Correlation With Dysplasia Severity and Malignant Potential of CD45RO⁺ T Cell Density in OLP and OED. OLP和OED中CD45RO+ T细胞密度与发育不良严重程度和恶性潜能的相关性

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-14 DOI: 10.1111/odi.70062

Qin Yu, Ziyue Yang, Shuo Sun, Tongtong Hu, Siyu Bian, Jingci Zhu, Can Xiao, Lifang Zhu

{"title":"Correlation With Dysplasia Severity and Malignant Potential of CD45RO+ T Cell Density in OLP and OED.","authors":"Qin Yu, Ziyue Yang, Shuo Sun, Tongtong Hu, Siyu Bian, Jingci Zhu, Can Xiao, Lifang Zhu","doi":"10.1111/odi.70062","DOIUrl":"https://doi.org/10.1111/odi.70062","url":null,"abstract":"Objective: This study investigates the role of CD45RO+ T cell densities in Oral lichen planus (OLP) and oral epithelial dysplasia with lichenoid features (OED), examining their distribution across different disease stages and their implications for disease progression and malignancy risk.Methods: Histopathological evaluation of 71 tissue samples identified 56 cases of OLP and 15 cases of OED. Subsequent analyses focused on the immunohistochemical expression of CD45RO.Results: CD45RO+ T-cell density showed a significant difference between OLP and OED (p = 0.024), with high-density expression notably prevalent in cases of severe dysplasia. A significant correlation was observed between CD45RO+ T-cell density and the histological grading of dysplasia (p = 0.015). Demographic analysis revealed that older patients exhibited higher CD45RO+ T cell densities (p < 0.001), though no significant correlation was found between age and the stages of OED (p = 0.93). High-density CD45RO+ T cells increased the odds of moderate to severe dysplasia (p = 0.01).Conclusion: CD45RO+ T cells show stage-specific distribution in oral epithelial dysplasia, suggesting prognostic relevance and offering insight into disease-related immune changes. These findings suggest diagnostic and therapeutic potential. With further validation in larger cohorts, CD45RO+ monitoring may serve as a useful clinical tool for risk stratification and early intervention, particularly in high-grade OED.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Precision: Validating the Oral Disease Recognition Scale. 诊断精度：验证口腔疾病识别量表。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-11 DOI: 10.1111/odi.70064

Kamran Ali, Daniel Zahra, Mahdi Mutahar, Muhammad Ali Malik, Mahwish Raja

{"title":"Diagnostic Precision: Validating the Oral Disease Recognition Scale.","authors":"Kamran Ali, Daniel Zahra, Mahdi Mutahar, Muhammad Ali Malik, Mahwish Raja","doi":"10.1111/odi.70064","DOIUrl":"https://doi.org/10.1111/odi.70064","url":null,"abstract":"Objective: To develop and validate a scale to assess the ability of dentists to recognize the clinical presentation of oral disease encompassing a range of benign, potentially malignant, and malignant conditions.Methods: The research employed a cross-sectional online survey methodology. Following ethical approval, a scale was developed by the research team and consisted of seven patient cases encompassing a range of benign, premalignant, and malignant oral conditions. The scale was pretested, and the external validity of the scale was evaluated.Results: Responses were received from a total of 254 participant. Interrogation of case performance data overall and by respondent subgroups, as well as consideration of response profiles, item analysis characteristics, reliability, and exploratory factor analysis support the existence of a single underlying construct that is measured consistently by the seven cases across respondent groups.Conclusions: This study developed and validated a scale to evaluate the abilities of dentists and oral health care professionals to recognize oral benign, premalignant, and malignant disorders. The scale may serve as a useful tool to assess clinicians' ability to recognize oral cancer and identify potential cognitive biases in their diagnostic approach.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0