Oral diseases最新文献_第5页

Demystifying "Hyaline Angiopathy" of Pulse Granuloma in Oral and Extraoral Surgical Pathology.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15287

Felipe Fornias Sperandio, Matheus de Castro Costa, Marina Lara de Carli, Rani Kanthan

{"title":"Demystifying \"Hyaline Angiopathy\" of Pulse Granuloma in Oral and Extraoral Surgical Pathology.","authors":"Felipe Fornias Sperandio, Matheus de Castro Costa, Marina Lara de Carli, Rani Kanthan","doi":"10.1111/odi.15287","DOIUrl":"https://doi.org/10.1111/odi.15287","url":null,"abstract":"Background and objectives: Pulse granuloma (PG), or giant cell hyaline angiopathy, is an immune-mediated reaction often following the implantation of plant-derived food particles. PGs are primarily found in the oral cavity and gastrointestinal tract and may represent a histopathological pitfall, being mistaken for other granulomatous conditions or tumors. This study is the first to compare oral to extraoral PGs, aiming to clarify the \"hyaline angiopathy\" seen in PGs by developing a detailed histochemical and immunohistochemical profile of oral and colonic PGs.Methods: A computer search of 135,972 surgical pathology cases was conducted. PG histopathological slides, along with demographic and clinical data, were reviewed. Stains including Congo red, Masson trichrome, PAS, and immunostains CD31, ERG, and D2-40 were applied.Results: Sixteen cases (11 oral, 5 extraoral) were identified, ranging from 7 to 81 years of age. Oral PGs were linked to odontogenic cysts, while extraoral PGs were associated with intestinal inflammation and perforation. Angiolymphatic marker expression was limited to the inflamed connective tissue surrounding PG.Conclusions: Our findings suggest that PGs reflect a granulomatous response to edible components and support surgical excision. The absence of vascular markers indicates that the term \"angiopathy\" is misleading, proposing that these \"wormy\" structures are fibrocollagenous responses.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Oral Squamous Cell Carcinoma From Colombia and Spain: A Retrospective Cohort Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15292

Ana María Rochel-Rochel, Julio Acero-Sanz, Juan Carlos de Vicente, Vito Carlo Alberto Caponio, Cristina Cárdenas-Serres, Catalina Cáceres Ramírez, Silvia Juliana Villabona Flórez, Viviana Jiménez Andrade, Diego Gómez Abreu, Francy Archilla Flórez, Rosa María López-Pintor

{"title":"Differences in Oral Squamous Cell Carcinoma From Colombia and Spain: A Retrospective Cohort Study.","authors":"Ana María Rochel-Rochel, Julio Acero-Sanz, Juan Carlos de Vicente, Vito Carlo Alberto Caponio, Cristina Cárdenas-Serres, Catalina Cáceres Ramírez, Silvia Juliana Villabona Flórez, Viviana Jiménez Andrade, Diego Gómez Abreu, Francy Archilla Flórez, Rosa María López-Pintor","doi":"10.1111/odi.15292","DOIUrl":"https://doi.org/10.1111/odi.15292","url":null,"abstract":"Objective: To compare the clinicopathological characteristics and survival of two cohorts of patients with oral squamous cell carcinoma (OSCC) from Spain and Colombia.Methods: Clinicopathological and survival variables of patients with OSCC from six maxillofacial surgery departments in Spain and Colombia were retrospectively reviewed. Variables were compared according to country of origin.Results: We included 649 patients, 359 from Spain and 290 from Colombia. The Colombian cohort was younger, drank more alcohol, had less comorbidities, and reported a greater mean number of days both from symptoms to diagnosis and from then to treatment, which was ∼2.5 times longer in the Colombian cohort. Colombian patients were diagnosed at a more advanced stage. The treatment of choice was resective surgery. In the Colombian cohort, more patients received radio and chemotherapy together with surgery. Second primary tumors and recurrences were more frequent in the Colombian sample (7.2% vs. 2.8%; p = 0.008) and in the Spanish cohort (32% vs. 23.1%; p = 0.012), respectively. Overall survival was similar between the two samples (HR = 1.15; 95% CI = 0.93-1.42; p = 0.195) and disease-specific survival was worse in the Colombian one (HR = 1.30; 95% CI = 1.03-1.65; p = 0.027).Conclusions: There were epidemiological differences between patients with OSCC in both cohorts and a longer delay in diagnosis and treatment in the Colombian sample.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of ¹⁸F-FDG PET/CT in LA-HNSCC Patients Undergoing Neoadjuvant Chemoimmunotherapy: A Prospective Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15276

Rong Huang, Xiaoxu Lu, Xueming Sun, Hui Wu

{"title":"Predictive Value of 18F-FDG PET/CT in LA-HNSCC Patients Undergoing Neoadjuvant Chemoimmunotherapy: A Prospective Study.","authors":"Rong Huang, Xiaoxu Lu, Xueming Sun, Hui Wu","doi":"10.1111/odi.15276","DOIUrl":"https://doi.org/10.1111/odi.15276","url":null,"abstract":"Objective: The study evaluates the efficacy of 18F-2-fluoro-2-deoxy-d-glucose FDG PET/CT in predicting outcomes in patients with advanced head and neck squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy.Methods: In this prospective study, we compared the parameters of 63 patients with LA-HNSCC who underwent 18F-FDG PET/CT before neoadjuvant chemoimmunotherapy, divided into responders (47) and non-responders (16), after three cycles of neoadjuvant chemoimmunotherapy. The ratio of the maximum standardized uptake value (SUVmax) of the primary tumor to the SUVmean of the normal tissue (muscle and blood) was recorded as the target background ratio (TBR muscle and TBR blood).Results: The SUVmean and TBRblood of the primary tumor were significantly lower in the responding group than in the non-responding group. Receiver operating characteristic (ROC) curve analysis identified SUVmean (area under the curve (AUC) = 0.931, p = 0.001) and TBRblood (AUC = 0.894, p = 0.001) as significant predictors of neoadjuvant chemoimmunotherapy efficacy. The study found that SUVmean, TBRblood, age, and Eastern Cooperative Oncology Group (ECOG) scores significantly correlated with short-term efficacy, while SUVmean was an independent predictor.Conclusion: In 18F-FDG PET/CT scans, higher baseline SUVmean and TBRblood were associated with a poor short-term response to neoadjuvant chemoradiotherapy in patients with LA-HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experiences, Challenges and Informational Needs of Patients With Oral Epithelial Dysplasia.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15289

Waleed Alamoudi, Richeal Ni Riordain, Stefano Fedele, Stephen Porter

{"title":"Experiences, Challenges and Informational Needs of Patients With Oral Epithelial Dysplasia.","authors":"Waleed Alamoudi, Richeal Ni Riordain, Stefano Fedele, Stephen Porter","doi":"10.1111/odi.15289","DOIUrl":"https://doi.org/10.1111/odi.15289","url":null,"abstract":"Objectives: This study aims to explore the patients' experiences with oral epithelial dysplasia (OED) to identify associated clinical challenges and informational needs.Methods: Semi-structured interviews, guided by a topic outline, addressed disease-specific information, investigative procedures, treatments, impacts on quality of life, healthcare systems and information sources. The interviews were audio recorded, transcribed verbatim and analysed using thematic analysis.Results: A total of 30 individuals participated in the study. Four primary themes were identified: delays in diagnosis, knowledge about OED, the psychological impact of the disease and patient education.Conclusion: To our knowledge, this is the first qualitative study to explore the lived experiences of patients with OED. It highlights significant challenges, including accessing appropriate medical services, delays in diagnosis, physical and psychological burdens and the need for better education. Positive experiences were noted when patients received care from knowledgeable clinicians who provided consistent education and effective communication. The findings of this study may guide the future development of measurement tools on the outcome measures of individuals with OED.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CCL19⁺ Fibroblasts Promote Tertiary Lymphoid Structure in Oral Lichen Planus: A Retrospective Study.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15266

Yi-Rao Lai, Lei Pan, Xin-Ke Jiang, Yi-Wen Deng, Ming-Hua Feng, Jin Li, Xiao-Zhe Han, Lei Sun, Yu-Feng Wang, Guo-Yao Tang

{"title":"CCL19+ Fibroblasts Promote Tertiary Lymphoid Structure in Oral Lichen Planus: A Retrospective Study.","authors":"Yi-Rao Lai, Lei Pan, Xin-Ke Jiang, Yi-Wen Deng, Ming-Hua Feng, Jin Li, Xiao-Zhe Han, Lei Sun, Yu-Feng Wang, Guo-Yao Tang","doi":"10.1111/odi.15266","DOIUrl":"https://doi.org/10.1111/odi.15266","url":null,"abstract":"Objectives: The priming mechanism of adaptive immunity in oral mucositis remains unclarified. This study aimed to elucidate the mechanisms of oral lichen planus (OLP), with a specific focus on the role of inducible tertiary lymphoid structures (iTLSs) and stromal-immune microenvironments within OLP.Materials and methods: We employed single-cell RNA sequencing and multiplex immunofluorescence staining to characterize the spatial characteristics and transcriptional signature of iTLSs in OLP. To investigate whether the presence of iTLSs influences the disease severity of OLP, we retrospectively collected clinical data from OLP patients.Results: Based on single-cell resolution analysis, we identified distinct cellular compositions and fibroblast-immune cells interactions within the iTLSs of OLP. We highlighted the critical role of CCL19+ fibroblasts in T-cell chemotaxis, promoting the development of iTLSs. Lymphotoxin was demonstrated to activate fibroblasts expressing CCL19. We revealed a significant correlation between the presence of iTLSs and increased severity of OLP, marked by more atrophic-erosive forms and higher disease scores in patients with iTLSs.Conclusions: The present research proposed the fibroblast-immune cell interactions within iTLSs as essential factors in OLP's inflammatory milieu, indicating iTLSs as the priming structure of T-cell immunity in the local oral mucosa.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Modified Intrabony Defect Model of Periodontitis in Rat.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15284

Pei Cao, Chen-Hao Yu, Yuan-Qing Liu, Liang Chen, Qing-Xian Luan, Jia Liu

{"title":"A Modified Intrabony Defect Model of Periodontitis in Rat.","authors":"Pei Cao, Chen-Hao Yu, Yuan-Qing Liu, Liang Chen, Qing-Xian Luan, Jia Liu","doi":"10.1111/odi.15284","DOIUrl":"https://doi.org/10.1111/odi.15284","url":null,"abstract":"Objective: The aim of this study was to compare the radiographic depth of the periodontal bone defect, as well as clinical and histological outcomes, between the proposed ligated defect model and the current non-ligated defect model, which often heals spontaneously and fails to replicate the complexities of periodontitis.Methods: The proposed model combined osteotomy to create controlled periodontal bone defects (depth of 1.5 mm) and ligature placement around the cervical region of the maxillary first molar to induce inflammation. Micro-CT analysis, clinical examinations, histological evaluations, and quantitative PCR were conducted to assess defect morphology, healing, and inflammatory marker expression over 6 weeks, compared with the non-ligated defect group, sham surgery group, and control.Results: Bone defect in the ligated defect group remained unhealed after surgery (1.525 ± 0.068 mm in depth at 2 weeks and 1.543 ± 0.082 mm at 6 weeks), with inflammatory cell infiltration and elevated expression of IL-1β, IL-6, and TNF-α, contrasting with observed healing from 1.328 ± 0.075 mm (2 weeks) to 0.593 ± 0.118 mm (6 weeks) in the non-ligated defect group.Conclusions: This model not only simulates the pathological features of periodontitis but also provides a reliable platform for testing innovative regenerative strategies and could lead to the development of specialized models for other periodontal conditions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Contaminated/Misidentified Cell Lines: A Critical Concern for Oral Cancer Research.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15295

Pedro Henrique Sette-de-Souza, Moan Jéfter Fernandes Costa

引用次数: 0

Real-World Study of Later-Line Anlotinib in R/M Head and Neck Squamous Cell Carcinoma.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-17 DOI: 10.1111/odi.15290

Houyu Ju, Yuanyuan Zhao, Minqi Zhao, Lingyan Chen, Xinrong Geng, Xuanli Xu, Guoxin Ren, Jingzhou Hu

{"title":"Real-World Study of Later-Line Anlotinib in R/M Head and Neck Squamous Cell Carcinoma.","authors":"Houyu Ju, Yuanyuan Zhao, Minqi Zhao, Lingyan Chen, Xinrong Geng, Xuanli Xu, Guoxin Ren, Jingzhou Hu","doi":"10.1111/odi.15290","DOIUrl":"https://doi.org/10.1111/odi.15290","url":null,"abstract":"Objectives: The option is rare for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) failed to prior-line immune checkpoint inhibitors (ICIs) and cetuximab-based treatment. The efficacy of salvage therapy was unsatisfied.Materials and methods: We collected the clinical data of R/M HNSCC patients progressed from prior-line immunotherapy and cetuximab therapy, and retrospectively analyzed the efficacy and toxicity of anlotinib-based therapy in these patients.Results: In total, 24 eligible participants were accrued between October 2021 and November 2024. Up to the cutoff time of November 1st, 2024, the objective response rate was 37.5%. Survival analysis revealed the median progression-free survival and overall survival was 4.27 months (95% CI, 1.53-7.01 months) and 8.67 months (95% CI, 5.62-11.72 months), respectively. For the safety, most common TRAEs with any grades were hypertension, hand-foot syndrome, gastrointestinal response, hemorrhage, hepatic dysfunction, and fatigue. Grade 3 or more TRAEs were observed in 3 (12.5%) patients, and no Grade 5 TRAEs were occurred.Conclusions: Our observations indicated that anlotinib-based therapy had considerable efficacy and well tolerance in R/M HNSCC patients failed to ICIs and cetuximab-based therapy, and might be acted as a novel and potentially effective option in later-line treatment of R/M HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15260

Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye

{"title":"Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye","doi":"10.1111/odi.15260","DOIUrl":"https://doi.org/10.1111/odi.15260","url":null,"abstract":"Background: Despite evidence suggesting a potential correlation between intestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) with periodontitis (PD), there is a lack of comprehensive systematic reviews and meta-analyses to consolidate these findings.Methods: This study investigates studies published until December 31, 2023, in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. The statistical analysis was conducted using Review Manager Version 5.4, calculating odds ratios (OR) and 95% confidence intervals (CI) based on the selected research papers, utilizing a fixed-effects model.Results: It demonstrates a significant increase in the risk of PD among patients with IBD, as indicated by an OR of 2.11 (95% CI: 1.80-2.49). Further analysis revealed elevated risks of PD for both Crohn's disease (CD) and ulcerative colitis (UC), with respective ORs of 1.96 (95% CI: 1.69-2.26) and 2.14 (95% CI: 1.85-2.47). A direct association was observed between CRC and PD, suggesting a 20% higher risk of PD in patients with CRC (OR = 1.20, 95% CI: 1.06-1.36).Conclusion: Our meta-analysis highlights the potential role of PD in managing systemic conditions like IBD and CRC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-10 DOI: 10.1111/odi.15281

Mohit Kothari, Silas Alves-Costa, Abhishek Kumar, Gustavo G Nascimento, Jørgen Feldbæk Nielsen, Peter Svensson, Simple F Kothari

{"title":"Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.","authors":"Mohit Kothari, Silas Alves-Costa, Abhishek Kumar, Gustavo G Nascimento, Jørgen Feldbæk Nielsen, Peter Svensson, Simple F Kothari","doi":"10.1111/odi.15281","DOIUrl":"https://doi.org/10.1111/odi.15281","url":null,"abstract":"Objectives: To evaluate the presence, severity and progression of temporomandibular disorders (TMD) in acquired brain injury (ABI) population and determine the diagnostic accuracy of 3Q/TMD and Fonseca Anamnestic Index (FAI) against the gold standard, Diagnostic Criteria for TMD (DC/TMD).Methods: ABI individuals were assessed using 3Q/TMD and FAI at admission (n = 73) and Week 4 (n = 52), while DC/TMD was conducted only at Week 4. Diagnostic accuracy, sensitivity and specificity of 3Q/TMD and FAI were calculated against DC/TMD.Results: TMD was detected in 66.0% (3Q/TMD) and 27.8% (FAI) at admission, with mild (75%) to moderate (25%) severity which was mostly pain-related. TMD frequency decreased to 11.3% (3Q/TMD) and 17.3% (FAI) by Week 4. Accuracy rates were 0.82 for 3Q/TMD and 0.83 for FAI. Sensitivity was 0.33 (3Q/TMD) and 0.50 (FAI), while specificity was high at 0.93 (3Q/TMD) and 0.90 (FAI).Conclusions: TMD presence was higher in an ABI population compared to the general population however the frequency decreased over time. The high specificity and accuracy of 3Q/TMD and FAI indicate their potentials as screening tools but their low sensitivity limits their effectiveness in identifying all TMD cases. Patients with ABI should be assessed for TMD as part of their comprehensive care.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0