Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-05-13 DOI:10.1111/odi.15384

Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, Chengwan Xia, Guowen Sun, Yumei Pu

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引用次数: 0

Abstract

Background: This study explored the feasibility and effectiveness of indocyanine green (ICG)-based near-infrared fluorescence (NIF) imaging for localizing bone lesions associated with medication-related osteonecrosis of the jaw (MRONJ) during surgical intervention.

Methods: A prospective observational study was conducted on 68 patients who underwent surgical treatment for MRONJ at a single institution between January 2021 and April 2024. Among them, 14 patients received surgery guided by NIF imaging, while the remaining patients underwent surgery without NIF guidance. Postoperative follow-up was performed to assess clinical outcomes.

Results: There were no significant differences between the two groups regarding age, medication type and duration, underlying disease, lesion location, clinical stage, concomitant symptoms, or surgical approach. NIF imaging remained stable in 14 patients who underwent MRONJ fluorescence surgery. The recurrence rate was lower in the NIF group (14.29%) than in the non-NIF group (27.78%). The difference in the recurrence-free survival curves between the two groups was statistically significant (p = 0.043).

Conclusion: ICG-mediated NIF imaging provides a reliable method for identifying MRONJ-related bone lesions and offers valuable intraoperative guidance, potentially improving surgical outcomes.

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术中ICG NIF成像定义MRONJ的手术切缘：一项前瞻性观察研究。

背景：本研究探讨了基于吲哚菁绿（ICG）的近红外荧光（NIF）成像在手术干预过程中定位颌骨药物相关性骨坏死（MRONJ）相关骨病变的可行性和有效性。方法：对2021年1月至2024年4月在同一机构接受MRONJ手术治疗的68例患者进行前瞻性观察研究。其中14例患者在NIF成像引导下进行手术，其余患者在无NIF引导下进行手术。术后随访评估临床结果。结果：两组患者在年龄、用药类型和持续时间、基础疾病、病变部位、临床分期、伴随症状、手术入路等方面无显著差异。在14例接受MRONJ荧光手术的患者中，NIF成像保持稳定。NIF组复发率（14.29%）低于非NIF组（27.78%）。两组无复发生存曲线差异有统计学意义（p = 0.043）。结论：icg介导的NIF成像为识别mronj相关骨病变提供了可靠的方法，并提供了有价值的术中指导，可能改善手术结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.