Oral diseases最新文献_第6页

Clinical Validation of ADAM9 as a Prognostic Biomarker in Oral Cancer. ADAM9作为口腔癌预后生物标志物的临床验证

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-16 DOI: 10.1111/odi.15383

Jeng-Wei Lu, Pei-Chen Shih, Show-Mei Chuang, Wan-Jung Tu, Ming-Heng Tsai, Yun-Jung Tsai, Shu-Hui Lin

{"title":"Clinical Validation of ADAM9 as a Prognostic Biomarker in Oral Cancer.","authors":"Jeng-Wei Lu, Pei-Chen Shih, Show-Mei Chuang, Wan-Jung Tu, Ming-Heng Tsai, Yun-Jung Tsai, Shu-Hui Lin","doi":"10.1111/odi.15383","DOIUrl":"https://doi.org/10.1111/odi.15383","url":null,"abstract":"Background: Oral cancer has a high incidence in Taiwan, and identifying prognostic biomarkers is crucial. This study investigated the role of a disintegrin and metalloprotease 9 (ADAM9) in oral cancer progression and outcomes.Methods: This study investigated ADAM9 protein expression in 353 oral cancer tissue specimens through immunohistochemical (IHC) analysis.Results: The analysis revealed that, among the 353 patients, 21 (6%) exhibited low ADAM9 expression, while the remaining 332 patients (94%) showed high ADAM9 expression, which correlated with advanced T status, poor overall survival, and unfavorable prognosis. Kaplan-Meier analysis confirmed that higher ADAM9 expression predicted significantly worse survival. Univariate and multivariate analyses identified ADAM9, histological grade, and AJCC stage as independent prognostic factors. Functionally, ADAM9 silencing in SAS and OC2 cells inhibited invasion and migration, downregulating matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 14 (MMP14). siRNA-mediated ADAM9 knockdown also reduced cell viability and migration, as confirmed by cell counting kit-8 and transwell assays. The Cancer Genome Atlas (TCGA) analysis further revealed a positive correlation between ADAM9 mRNA levels and matrix metalloproteinase 2 (MMP2) or MMP14 expression in oral cancer patients.Conclusions: This study identifies ADAM9 as a key driver of oral cancer in a Taiwanese cohort and highlights its diagnostic and therapeutic potential.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Oral Melanocytic Nevi in Sun-Exposed and Sun-Protected Regions. 日晒和防晒地区口腔黑素细胞痣的特征。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-12 DOI: 10.1111/odi.15404

Thalita Soares Tavares, Adriana Aparecida Silva da da Costa, Marina Gonçalves Diniz, Daniela Pereira Meirelles, Sandra Beatriz Chaves Tarquínio, Ana Carolina Uchoa Vasconcelos, Aline Cristina Batista Rodrigues Johann, Ricardo Santiago Gomez, de Aguiar, Patrícia Carlos Caldeira

{"title":"Characterization of Oral Melanocytic Nevi in Sun-Exposed and Sun-Protected Regions.","authors":"Thalita Soares Tavares, Adriana Aparecida Silva da da Costa, Marina Gonçalves Diniz, Daniela Pereira Meirelles, Sandra Beatriz Chaves Tarquínio, Ana Carolina Uchoa Vasconcelos, Aline Cristina Batista Rodrigues Johann, Ricardo Santiago Gomez, de Aguiar, Patrícia Carlos Caldeira","doi":"10.1111/odi.15404","DOIUrl":"https://doi.org/10.1111/odi.15404","url":null,"abstract":"Objective: Oral melanocytic nevi (OMN) are histologically similar to skin nevi; however, they are much rarer and not always related to sun exposure. This study aimed to characterize the histopathological, immunohistochemical, and molecular features of OMN in sun-exposed (vermilion lip) and sun-protected (intraoral) regions.Method: Cross-sectional study on 14 intraoral and 20 vermilion lip OMN. Hematoxylin-eosin, immunohistochemistry for TRP2 and MiTF, and RT-qPCR for TRP2 and MiTF were used to assess histopathology, protein, and mRNA expression, respectively. Statistical analysis was performed.Results: Intramucous and blue nevi are the most frequent histological subtypes. Intraoral lesions predominantly affect Brown or Black individuals (64.3%), presenting mostly as macules. Vermilion lip nevi affect White individuals (75%), with elevated lesions (30%). Histologically, intraoral nevi show asymmetric, lack theques formation and floret cells, and present no mitotic activity or pleomorphism, while vermilion nevi display pleomorphism, symmetry, theques formation, floret cells, and solar elastosis. TRP2 and MiTF protein and mRNA expression were upregulated in both groups (p < 0.05), with no differences between them (p > 0.05).Conclusions: Intraoral and vermilion lip nevi have distinct histopathological features, but similar TRP2 and MiTF protein and mRNA expression. This characterization may aid the histopathological diagnosis of OMN and distinction from other oral pigmentations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Applications and Mechanisms of Klotho in Periodontitis Diagnosis and Therapy. Klotho在牙周炎诊治中的临床应用及作用机制。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-12 DOI: 10.1111/odi.15402

Chengyu Wan, Yalan Yang, Bozhao Wang, Jian Li

{"title":"Clinical Applications and Mechanisms of Klotho in Periodontitis Diagnosis and Therapy.","authors":"Chengyu Wan, Yalan Yang, Bozhao Wang, Jian Li","doi":"10.1111/odi.15402","DOIUrl":"https://doi.org/10.1111/odi.15402","url":null,"abstract":"Objectives: Periodontitis is a prevalent chronic inflammatory condition affecting the periodontal supporting tissue, and Klotho has anti-inflammatory and antioxidant effects. In recent years, some emerging evidence has revealed a link between Klotho and periodontitis. This review aims to elucidate the effects of Klotho in periodontitis and summarize the methods to increase Klotho levels for clinical treatment.Subjects and methods: We conducted a systematic search of PubMed, Web of Science, and Embase databases to review the current research status of Klotho in relation to periodontitis and its roles in periodontal disease mechanisms.Results: Klotho demonstrates anti-inflammatory, antioxidant, autophagy-enhancing, and alveolar bone regeneration-promoting effects in periodontitis. Feasible strategies to elevate Klotho levels in humans include exogenous supplementation of Klotho and modulation of its upstream regulatory pathways.Conclusion: Klotho and its associated enhancers show significant therapeutic potential for the management of periodontitis; however, the underlying mechanisms and more clinical studies are still lacking, and further research is needed.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KL-12 Peptide Targets Peri-Implantitis via Dual Antibacterial and Immunomodulatory Effects. KL-12肽通过双重抗菌和免疫调节作用靶向种植体周围炎。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-12 DOI: 10.1111/odi.15401

Jiahao Qin, Shuwei Yang, Weixu Meng, Zanxun Zhou, Zihui Yu, Xi Zhang

{"title":"KL-12 Peptide Targets Peri-Implantitis via Dual Antibacterial and Immunomodulatory Effects.","authors":"Jiahao Qin, Shuwei Yang, Weixu Meng, Zanxun Zhou, Zihui Yu, Xi Zhang","doi":"10.1111/odi.15401","DOIUrl":"https://doi.org/10.1111/odi.15401","url":null,"abstract":"Aims: Peri-implantitis is a common dental complication characterized by inflammation of peri-implant tissues and progressive bone loss. With the rise of antibiotic resistance, this study investigates the potential of antimicrobial peptides (AMPs), specifically KL-12, a novel peptide derived from cecropin B, as an alternative therapeutic strategy against Porphyromonas gingivalis, a key pathogen in peri-implantitis.Methods: We evaluated the structural stability, antibacterial efficacy, and cytotoxicity of KL-12. Antibacterial activity was measured against P. gingivalis, while the peptide's mode of action was explored concerning its effect on the gingipain proteases essential for the bacterium's nutrient acquisition. Additionally, we assessed KL-12's impact on macrophage polarization and anti-inflammatory responses.Results: The findings revealed that KL-12 exhibited significant antibacterial activity against P. gingivalis and demonstrated potential as a specific inhibitor of gingipains. It was observed that KL-12 disrupts bacterial viability through mechanisms involving deformation and nutrient deprivation, rather than traditional pore formation. KL-12 effectively modulated macrophage polarization, promoting M2 differentiation and enhancing anti-inflammatory responses.Conclusion: These results suggest that KL-12 functions as a dual-action therapeutic agent, targeting both bacterial pathogens and inflammatory processes in the management of peri-implantitis. Future studies will aim to clarify the molecular mechanisms underlying KL-12's antibacterial and immunomodulatory effects.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Cell RNA Sequencing Study on Two Synovial Derived Tumors in the Temporomandibular Joint. 两种颞下颌关节滑膜衍生肿瘤的单细胞RNA测序研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-11 DOI: 10.1111/odi.70003

Weihua Han, Tiansong Xu, Zonghan He, Haiyan Luo, Chuanbin Guo, Juanhong Meng

{"title":"Single-Cell RNA Sequencing Study on Two Synovial Derived Tumors in the Temporomandibular Joint.","authors":"Weihua Han, Tiansong Xu, Zonghan He, Haiyan Luo, Chuanbin Guo, Juanhong Meng","doi":"10.1111/odi.70003","DOIUrl":"https://doi.org/10.1111/odi.70003","url":null,"abstract":"Objective: To investigate the cellular composition and differentiation trajectory of synovial chondromatosis (SC) and diffuse tenosynovial giant cell tumor (D-TSGCT) in the temporomandibular joint (TMJ).Materials and methods: Single-cell RNA sequencing was applied to analyze the cellular composition, differentiation trajectory, and intercellular communication of SC and D-TSGCT. Cell culture and morphological experiments were applied to validate the chondrogenic differentiation potential of fibroblast-like synoviocytes (FLS) in the initial stage of SC and to explore the expression and regulation of differential genes during chondrogenic differentiation.Results: SC was mainly composed of FLS and chondrocytes, while D-TSGCT had a relatively complex cellular composition. Genetically, chondrogenesis-related genes such as COMP and SMAD2 were upregulated in the early stage of SC. TGFβ pathway and collagen catabolic process were subsequently activated, ultimately leading to cartilage formation. CSF1 and CD68 were overexpressed at the forming stage of D-TSGCT, and the macrophage pathway was enriched in the later phase. Based on experimental verification, COMP could induce chondrogenic differentiation of FLS by activating TGFβ/SMAD signal pathways in vitro.Conclusions: FLS are the common starting point of synovial-derived tumors, but differentiate toward different endpoints in the SC and D-TSGCT. COMP/TGFβ/SMAD signaling pathways can promote chondrogenic differentiation of synovium in SC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Proliferative Ability and Accumulation of Cancer Stem Cells in Oral Submucous Fibrosis Epithelium". 对“口腔黏膜下纤维化上皮肿瘤干细胞的增殖能力和积累”的修正。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-11 DOI: 10.1111/odi.15386

引用次数: 0

Exploratory Advanced Radiotherapies for Ameloblastoma and Ameloblastic Carcinoma-A Concise Review. 成釉细胞瘤和成釉细胞癌的先进放射治疗研究综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-10 DOI: 10.1111/odi.15403

Heba Turkstani, Afrah Alfaifi, Sunday O Akintoye

{"title":"Exploratory Advanced Radiotherapies for Ameloblastoma and Ameloblastic Carcinoma-A Concise Review.","authors":"Heba Turkstani, Afrah Alfaifi, Sunday O Akintoye","doi":"10.1111/odi.15403","DOIUrl":"10.1111/odi.15403","url":null,"abstract":"Objective: Ameloblastoma is an aggressively growing odontogenic tumor with substantial management challenges and a high recurrence rate. Surgical resection is the treatment of choice for ameloblastoma, but adjuvant therapies like radiation have been explored in cases where surgery is not clinically advisable and the tumor is inoperable. This short review assessed ameloblastoma case reports for outcomes of advanced radiation therapy modalities.Methods: PubMed, Google Scholar, Embase, Web of Science, and Scopus databases were queried for outcomes of ameloblastoma treated with helical tomotherapy, gamma knife radiosurgery, proton beam therapy, and carbon ion therapy. Patient outcomes were assessed based on tumor response, radiation side effects, and tumor recurrence.Results: Seven of nine (78%) cases showed tumor regression or complete response, with no disease progression during follow-up that ranged from 3 months to 5 years. The remaining two had partial regression or stable disease. Treatment side effects were generally mild, with 6 cases reporting grade 1-3 dermatitis, mucositis, or xerostomia. Two cases experienced severe toxicity, including grade 3 mucositis and radiation retinopathy.Conclusion: Advanced radiation techniques offer a promising alternative or adjuvant therapy for ameloblastoma in cases where surgery is contraindicated. However, more studies are needed to validate these findings.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chinese Expert Consensus on Management of Betel-Chewing-Related Oral Squamous Cell Carcinoma. 中国专家对槟榔咀嚼相关口腔鳞状细胞癌治疗的共识。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15397

Wei Guo, Rongfa Bu, Longjiang Li, Moyi Sun, Shan Gao, Guoxin Ren, Xin Peng, Wei Shang, Pu Xu, Jian Meng, Lu Xing, Binjie Liu, Yanjia Hu, Bo Li, Xin Bin, Zhangui Tang

{"title":"Chinese Expert Consensus on Management of Betel-Chewing-Related Oral Squamous Cell Carcinoma.","authors":"Wei Guo, Rongfa Bu, Longjiang Li, Moyi Sun, Shan Gao, Guoxin Ren, Xin Peng, Wei Shang, Pu Xu, Jian Meng, Lu Xing, Binjie Liu, Yanjia Hu, Bo Li, Xin Bin, Zhangui Tang","doi":"10.1111/odi.15397","DOIUrl":"https://doi.org/10.1111/odi.15397","url":null,"abstract":"Objective: Betel-chewing-related oral squamous cell carcinoma (BCR-OSCC) has become a global health issue with increasing incidence year by year around the world. Active prevention of the occurrence of BCR-OSCC, monitoring the population exposed to Betel Nuts, and early diagnosis and treatment are very important to maintain and improve the quality of life of patients. However, there is currently no consensus or guideline that provides targeted guidance on the management of BCR-OSCC.Subjects and methods: A consensus panel consisting of 15 leading Chinese experts from multidisciplinary fields was convened, and a roundtable meeting was held to discuss the topics of BCR-OSCC.Results: Based on existing research reports and the experts' clinical experiences, a consensus on staging, diagnosis, and treatment for BCR-OSCC was formed through extensive discussion.Conclusion: This manuscript presents consensus recommendations and a summary of evidence supporting each recommendation. This consensus may improve clinical practices about BCR-OSCC in China and propel more clinical trials to provide high-level evidence for BCR-OSCC management.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Current State of Clinical Diagnostic Algorithms for Mucosal Oral Lesions: A Scoping Review. 口腔黏膜病变临床诊断算法的现状：范围综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15388

Mohammed Al-Shehri, Theerthika Dillibabu, Belinda Nicolau, Marco Magalhaes, Nicholas Makhoul, Faleh Tamimi, Peter Chauvin, Sreenath Madathil

{"title":"The Current State of Clinical Diagnostic Algorithms for Mucosal Oral Lesions: A Scoping Review.","authors":"Mohammed Al-Shehri, Theerthika Dillibabu, Belinda Nicolau, Marco Magalhaes, Nicholas Makhoul, Faleh Tamimi, Peter Chauvin, Sreenath Madathil","doi":"10.1111/odi.15388","DOIUrl":"https://doi.org/10.1111/odi.15388","url":null,"abstract":"Background: Diagnosing oral lesions remains challenging for many dentists. Despite the availability of diagnostic algorithms, there is a dearth of comprehensive evidence synthesis and a discussion on their clinical and pedagogical applicability.Methods: A scoping review was conducted to identify: (1) algorithms or flow diagrams that help clinicians to diagnose oral lesions in a clinical setting without additional software; (2) publications in English; (3) all age groups; (4) algorithms for oral lesions of soft tissue only. We excluded those that are: (1) black-box; (2) required additional tests; (3) older versions; (4) for non-mucosal lesions, and (5) intended for self-screening. A keyword and MeSH term search was performed across three peer-reviewed publication databases and gray literature.Results: Seventeen algorithms from 15 peer-reviewed manuscripts and 1 online course were identified. Most studies did not mention how the algorithms were developed, and none had been validated in a clinical setting. The algorithms often focused on one or two types of lesions and were incomplete in differential diagnoses.Conclusion: Few clinical diagnostic algorithms for oral lesions are available in the literature. Notably, there are no validated and comprehensive clinical diagnostic algorithms for oral mucosal lesions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease. 健康和疾病中颅面植入区微生物组和元蛋白质组。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15398

Daniela Lattuf Cortizo, Renato C V Casarin, Hélvis E S Paz, Camila S Stolf, Mabelle F Monteiro, Mônica T V Labate, Márcio Z Casati, Luciano Lauria Dib

{"title":"Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease.","authors":"Daniela Lattuf Cortizo, Renato C V Casarin, Hélvis E S Paz, Camila S Stolf, Mabelle F Monteiro, Mônica T V Labate, Márcio Z Casati, Luciano Lauria Dib","doi":"10.1111/odi.15398","DOIUrl":"https://doi.org/10.1111/odi.15398","url":null,"abstract":"Background: Craniofacial defects from cancer surgery led to functional, aesthetic, and psychological challenges. Rehabilitation with craniofacial implants addresses these issues by improving prosthesis retention through osseointegration and providing predictable cosmetic results. However, maintaining a healthy transcutaneous region is essential for implant longevity.Objective: Evaluation of the microbial community and host response around extraoral implants.Methods: In an intrasubject control study design, 12 cancer patients who had undergone oculofacial rehabilitation with implant-supported prostheses were included. Biofilm and peri-implant fluid samples were collected from the transcutaneous region of healthy and diseased implants. Microbiome profiling was conducted through DNA sequencing of the V3-V4 region of the 16S rRNA gene, and proteome analysis was performed using liquid chromatography-tandem mass spectrometry.Results: Differentially abundant species were observed, with Streptococcus intermedius being the most abundant in diseased areas, followed by Corynebacterium diphtheriae and Prevotella bivia. Metaproteomic analysis revealed distinct protein expression patterns between the groups, with increased activation of proinflammatory responses and inactivation of anti-inflammatory responses in the diseased group.Conclusion: The study demonstrated an increased abundance of pathogenic bacterial community accompanied by an imbalanced immune response, thereby highlighting host-microbial factors that can influence the success of osseointegration and facial rehabilitation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0