Oral diseases最新文献_第6页

HOXC6 Activates BCAT1 Expression to Promote Oral Cancer Development. HOXC6激活BCAT1表达促进口腔癌发展

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-05 DOI: 10.1111/odi.70049

Meiheriban Tuerhong, Zaynure Wubulihasimu, Bo Xu, Ling Zhang

{"title":"HOXC6 Activates BCAT1 Expression to Promote Oral Cancer Development.","authors":"Meiheriban Tuerhong, Zaynure Wubulihasimu, Bo Xu, Ling Zhang","doi":"10.1111/odi.70049","DOIUrl":"https://doi.org/10.1111/odi.70049","url":null,"abstract":"Objective: This paper aims to reveal the impact of HOXC6 on oral cancer development through the regulation of BCAT1 and the molecular mechanism.Methods: BCAT1 expression in oral cancer tissues and adjacent tissues was verified by western blot analysis and RT-qPCR. After knocking down BCAT1, the HN6 and HN30 cell proliferation, migration, invasion, and apoptosis were detected. The upstream mechanism of BCAT1 elevation was investigated by bioinformatics analysis. HOXC6 expression was detected by immunohistochemistry in oral cancer and adjacent tissues. ChIP and dual-luciferase assay were used to detect the interaction between HOXC6 and the BCAT1 promoter. Rescue experiments were carried out to substantiate the malignant phenotype and epithelial-to-mesenchymal transition (EMT) of oral cancer cells. An in vivo xenograft tumor model was constructed.Results: BCAT1 and HOXC6 were abnormally high in oral cancer tissues. Inhibition of BCAT1 suppressed the proliferation, migration, invasion, and EMT, and promoted apoptosis of oral cancer cells. HOXC6 downregulation curbed the malignant behavior and EMT program of oral cancer cells. HOXC6 was enriched in the BCAT1 promoter in oral cancer cells. HOXC6 silencing downregulated BCAT1 expression. Transcriptional activation of BCAT1 by HOXC6 promoted oral cancer progression.Conclusion: HOXC6 knockdown inhibits BCAT1 expression to suppress oral cancer development.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal AI as a Pedagogical Tool: Early Impressions of Google's NotebookLM in Teaching Oral Diseases. 多模态人工智能作为教学工具：b谷歌的NotebookLM在口腔疾病教学中的早期印象。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70053

John Lennon Silva Cunha

引用次数: 0

New Insights Into Diffuse Sclerosing Osteomyelitis: Is There a Role of ANA and Vitamin B6? 弥漫性硬化性骨髓炎的新认识：ANA和维生素B6是否有作用？

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70028

Katharina Theresa Obermeier, Tim Hildebrandt, Ina Dewenter, Wenko Smolka, Eric Hesse, Philipp Poxleitner, Sven Otto

{"title":"New Insights Into Diffuse Sclerosing Osteomyelitis: Is There a Role of ANA and Vitamin B6?","authors":"Katharina Theresa Obermeier, Tim Hildebrandt, Ina Dewenter, Wenko Smolka, Eric Hesse, Philipp Poxleitner, Sven Otto","doi":"10.1111/odi.70028","DOIUrl":"https://doi.org/10.1111/odi.70028","url":null,"abstract":"Object: Diffuse sclerosing osteomyelitis is a poorly understood chronic disease, which appears predominantly in the mandible. Female patients are more often affected than men. DSO is an ultra-rare disease and incidence is unknown; diagnosis can be very challenging; pathogenesis is poorly understood.Subjects and methods: In this prospective study, blood samples were collected from a total of 25 patients and analyzed to detect altered laboratory values to have insight into possible pathomechanism. Patients were divided into three groups: Group A: patients with DSO, Group B: patients with osteomyelitis and medication-related osteonecrosis, and Group C: healthy control group.Results: 44% of all patients in group A had elevated Vitamin B6 levels. Compared to groups B and C, these levels were statistically significantly higher (p = 0.011, p = 0.015). 23 patients had increased (92%) antinuclear-antibody-titer (ANA-Titer); in group B, 52% of all patients, and in the healthy control group, 44%.Conclusions: Elevated ANA titers and elevated vitamin B6 levels provide a possible insight into the pathomechanisms of DSO. Therefore, in the search for the pathogenesis and etiology of DSO, autoimmune processes should also be considered.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: "Could Long COVID Oral Symptoms and COVID-19 Vaccination Oral Side Effects be Induced by the Spike Protein?" 评论：“长时间的COVID-19口腔症状和COVID-19疫苗口服副作用会由Spike蛋白诱导吗？”

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70056

Lucas Alves da Mota Santana, Lara Góis Floresta, Gilmagno Amado Santos, Juliana Batista Melo da Fonte, Lysandro Pinto Borges

引用次数: 0

Comment on "Tongue Coating Metabolic Profiles of Intraoral Halitosis Patients". 对“口腔内口臭患者舌苔代谢谱”的评论。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70059

Shuang Pang, Feifei Gu, Jing Hu, Liping Yue

引用次数: 0

The Paradoxical Influence of Hyperthermia on Progression-Free Survival in Recurrent/Metastatic Oral Cancer Treated With Immune Checkpoint Inhibitors. 热疗对免疫检查点抑制剂治疗复发/转移口腔癌患者无进展生存的矛盾影响

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70051

Shogo Kikuta, Chikayuki Hattori, Yushi Abe, Kiyosato Hino, Katsuhisa Matsuo, Jingo Kusukawa

{"title":"The Paradoxical Influence of Hyperthermia on Progression-Free Survival in Recurrent/Metastatic Oral Cancer Treated With Immune Checkpoint Inhibitors.","authors":"Shogo Kikuta, Chikayuki Hattori, Yushi Abe, Kiyosato Hino, Katsuhisa Matsuo, Jingo Kusukawa","doi":"10.1111/odi.70051","DOIUrl":"https://doi.org/10.1111/odi.70051","url":null,"abstract":"Background: Clinical evidence for combining hyperthermia (HT) with immune checkpoint inhibitors (ICIs) in recurrent/metastatic oral cancer (RM-OC) is lacking. To our knowledge, this is the first study to investigate the clinical impact of this combination therapy in this specific cohort.Methods: We retrospectively analyzed 35 patients with RM-OC treated with ICIs. Patients receiving concurrent HT (n = 8) were compared to those without HT (n = 27). Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier and Cox proportional hazards models.Results: A significant discordance between endpoints emerged. Multivariate analysis revealed that concurrent HT was paradoxically associated with significantly worse PFS (hazard ratio, 3.06; 95% confidence interval, 1.08-8.64; p = 0.035). In stark contrast, HT had no corresponding negative impact on OS (median OS: 26.2 vs. 30.2 months; p = 0.53).Conclusion: Concurrent HT with ICI therapy was paradoxically associated with diminished PFS without impacting OS. This critical discordance suggests that the observed radiographic progression may reflect intense, HT-induced immune-related inflammation (pseudoprogression) rather than true tumor progression. These findings underscore the complexity of interpreting efficacy endpoints for this novel combination therapy and highlight the need to reconsider standard response evaluation criteria.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Diagnostic Performance of Multimodal Large Language Models in the Analysis of Oral Pathology". “多模态大语言模型在口腔病理分析中的诊断性能”述评

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70055

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

HIF-1/2α: The Silent Architects of Adenoid Cystic Carcinoma-A Systematic Review and Meta-Analysis. HIF-1/2α：腺样囊性癌的沉默缔造者——系统回顾和meta分析

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70048

R Maheswari, Akhilesh Chandra, Rahul Agrawal

{"title":"HIF-1/2α: The Silent Architects of Adenoid Cystic Carcinoma-A Systematic Review and Meta-Analysis.","authors":"R Maheswari, Akhilesh Chandra, Rahul Agrawal","doi":"10.1111/odi.70048","DOIUrl":"https://doi.org/10.1111/odi.70048","url":null,"abstract":"Background: Adenoid cystic carcinoma (AdCC) is a rare, aggressive salivary gland malignancy with a poor prognosis due to metastasis and local recurrence. Although hypoxia-inducible factors-1/2α (HIF-1/2α) play crucial roles in AdCC, their pleiotropic effects remain poorly understood. This systematic review and meta-analysis evaluates the impact of HIF-1/2α in AdCC progression.Methods: A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and Web of Science to identify studies examining HIF-1/2α in AdCC. Study quality was assessed using the modified Newcastle-Ottawa scale, and meta-analyses were performed using IBM SPSS Statistics (Version 29).Results: Sixteen studies met inclusion criteria, with 10 studies encompassing 650 AdCC cases included in the meta-analysis. Positive HIF-1/2α expression was reported in 77.4% of AdCC cases (95% CI: 0.630-0.919, p < 0.001) and was significantly correlated with tumor size (OR: 0.38, 95% CI: 0.16-0.89, p = 0.03), advanced stage (OR: 2.86, 95% CI: 1.74-4.71, p < 0.001), and distant metastasis (OR: 1.82, 95% CI: 1.02-3.25, p = 0.04). Human studies demonstrated significantly increased HIF-1/2α protein and mRNA expression in AdCC cases compared to control groups. Solid-type AdCC exhibited predominantly higher nuclear HIF-1α expression than cribriform and tubular subtypes. Additionally, in cell culture models, the hypoxia-induced upregulation of these factors increased the expression of VEGF (20-fold), BNIP3 (6-fold), and NID1, promoting angiogenesis, epithelial-mesenchymal transition, autophagy, and invasiveness.Conclusion: HIF-1/2α emerge as a pivotal drivers of AdCC progression, serving dual roles as prognostic biomarker and therapeutic target, necessitating further clinical investigation through multicenter validation studies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural Practices and Oral Cancer Risk in the Middle East: A Systematic Review. 中东地区文化习俗与口腔癌风险：一项系统综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70060

Omar Museedi, Bashar Abdullah, Saman Warnakulasuriya

{"title":"Cultural Practices and Oral Cancer Risk in the Middle East: A Systematic Review.","authors":"Omar Museedi, Bashar Abdullah, Saman Warnakulasuriya","doi":"10.1111/odi.70060","DOIUrl":"https://doi.org/10.1111/odi.70060","url":null,"abstract":"Objective: To systematically review evidence on how cultural practices influence oral squamous cell carcinoma (OSCC) risk in Middle-Eastern populations.Methods: This PRISMA-conform systematic review searched PubMed, Scopus, and regional databases (1990-Dec 2024) for studies examining cultural practices and OSCC risk in the Middle East. Forty studies were qualitatively synthesized; 20 provided data for random-effects meta-analyses.Results: Smokeless tobacco (shammah: pooled OR 3.9, 95% CI 2.5-6.2) and qat chewing (pooled OR 2.7, 1.9-3.8) were major risk factors, exhibiting dose-response relationships and contributing to significant regional incidence variations. Opium use was associated with increased risk in one Iranian study (OR 2.55, 1.47-4.43). Waterpipe (pooled OR 2.6, 1.8-3.9) and cigarette smoking (pooled OR 3.7, 2.9-4.8) also significantly increased risk. A Mediterranean dietary pattern showed protection (pooled OR 0.6, 0.4-0.9). Education below secondary level tripled risk (pooled OR 2.6, 1.9-3.5). Female-to-male incidence ratios approached parity in high-shammah use regions, diverging from typical global patterns.Conclusions: Culturally embedded, dose-dependent tobacco and qat habits are primary drivers of OSCC risk in the Middle East, modified by sex and socioeconomic status. Prevention strategies must extend Framework Convention measures to smokeless tobacco, address combined tobacco-qat use, and employ gender- and equity-sensitive approaches, guided by the unique cultural context.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply "Could Long COVID Oral Symptoms and COVID19 Vaccination Oral Side Effects Be Induced by the Spike Protein?" 作者回复“长时间的COVID口腔症状和COVID疫苗口服副作用会由Spike蛋白诱导吗？”

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70052

Hironori Tsuchiya

引用次数: 0