Oral diseases最新文献_第6页

Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification. 基于 2022 年世界卫生组织分类的 4777 例囊肿和牙源性肿瘤的流行病学特征。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15146

Victoria Rees, Matías Klare, Valentina Samaniego, Felipe Leiva, René Jara, Benjamín Martínez Rondanelli, Sergio González Providell

{"title":"Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification.","authors":"Victoria Rees, Matías Klare, Valentina Samaniego, Felipe Leiva, René Jara, Benjamín Martínez Rondanelli, Sergio González Providell","doi":"10.1111/odi.15146","DOIUrl":"https://doi.org/10.1111/odi.15146","url":null,"abstract":"Objective: The epidemiology of cysts and odontogenic tumors is important for differential diagnosis and treatment strategies. We aimed to describe the epidemiological features of cysts and odontogenic tumors in the Chilean population using the current WHO classification.Materials and methods: We reviewed 22,914 biopsy requests received between January 1984 and September 2023 at the oral pathology department, School of Dentistry, Universidad Mayor, Santiago, Chile. Patients diagnosed with cysts of the jaws and odontogenic tumors were selected and information regarding age, sex, and location was recorded.Results: 4226 (18.4%) were cysts, and 551 (2.4%) were odontogenic tumors, ranging from 2 to 97 years old. Males represented 54.4% and females 45.7% of the total sample. The most prevalent cysts were radicular cysts (58.6%), dentigerous cysts (17.9%), and odontogenic keratocysts (13.3%). The most prevalent odontogenic tumors were odontomas (40.1%) and conventional ameloblastoma (17.6%).Conclusions: Our study was the first retrospective analysis to determine the epidemiological features of both cysts and odontogenic tumors together, based on the 2022 WHO classification. This is relevant as it offers a potential basis for comprehensive comparisons of the epidemiological features of these entities, which could contribute to an accurate differential diagnosis, therefore, leading to more effective therapeutic interventions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' reply "Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study". 回复编辑：放疗或化放疗后种植体损失的潜在因素。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14888

Jamie M Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A H J de Visscher, Max J H Witjes, Johannes A Langendijk, Gerry M Raghoebar

引用次数: 0

USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination. USP14 通过促进 SOX2 的去泛素化促进 OSCC 的癌干样细胞特性。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14896

Chang Liu, Shijie Zhou, Wei Tang

{"title":"USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination.","authors":"Chang Liu, Shijie Zhou, Wei Tang","doi":"10.1111/odi.14896","DOIUrl":"10.1111/odi.14896","url":null,"abstract":"Objective: USP14 (Ubiquitin-specific-processing protease 14) is a deubiquitinating enzyme with oncogenic effects in oral squamous cell carcinoma (OSCC). This study aims to identify new substrates of USP14 and elucidate their role in modulating cancer stem-like cells (CSCs) in OSCC.Materials and methods: Bioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively. OSCC cell lines and patient-derived cells were used for experimental validation, employing co-immunoprecipitation, cycloheximide chase assays, and tumor sphere formation to evaluate the effects of USP14 on SOX2 stability, ubiquitination, and CSC phenotypes.Results: USP14 upregulation was associated with worse overall survival and progression-free interval in OSCC. USP14 interacted with SOX2 with its ubiquitin carboxyl-terminal hydrolase domain. USP14 knockdown impaired SOX2 stability by increasing its polyubiquitination. Ectopic overexpression of wild-type USP14, but not the hydrolase-deficient-mutant USP14C114A, enhanced SOX2 stability by reducing polyubiquitination. USP14 knockdown suppressed OSCC cell proliferation, colony formation, and tumor sphere formation in vitro and tumor growth in vivo. However, the reduction of CSC markers following USP14 knockdown was mitigated by overexpressing SOX2. These findings were verified in OSCC patient-derived CSC cells.Conclusion: This study revealed a USP14-SOX2 axis regulating the CSC properties of OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRE1α inhibits osteogenic differentiation of mouse embryonic fibroblasts by limiting Shh signaling. IRE1α 通过限制 Shh 信号抑制小鼠胚胎成纤维细胞的成骨分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1111/odi.14919

Zhixiang Zhang, Xuan Zhang, Xiangzhen Wei, Chengbo Yu, Li Xiao, Jianmiao Liu, Yong Liu, Yingguang Cao, Ke Song

{"title":"IRE1α inhibits osteogenic differentiation of mouse embryonic fibroblasts by limiting Shh signaling.","authors":"Zhixiang Zhang, Xuan Zhang, Xiangzhen Wei, Chengbo Yu, Li Xiao, Jianmiao Liu, Yong Liu, Yingguang Cao, Ke Song","doi":"10.1111/odi.14919","DOIUrl":"10.1111/odi.14919","url":null,"abstract":"Objectives: This study aimed to investigate the effect of endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) on the sonic hedgehog N-terminus (N-Shh)-enhanced-osteogenic differentiation process in mouse embryonic fibroblasts (MEFs).Materials and methods: Osteogenesis of MEFs was observed by alkaline phosphatase (ALP) staining, alizarin red staining, and Von Kossa staining assays. Activation of unfolded protein response and Shh signaling were examined using real-time quantitative PCR and western blot assays. IRE1α-deficient MEFs were used to explore the effect of IRE1α on N-Shh-driven osteogenesis.Results: N-Shh increased ALP activity, matrix mineralization, and the expression of Alp and Col-I in MEFs under osteogenic conditions; notably, this was reversed when combined with the ER stress activator Tm treatment. Interestingly, the administration of N-Shh decreased the expression of IRE1α. Abrogation of IRE1α increased the expression of Shh pathway factors in osteogenesis-induced MEFs, contributing to the osteogenic effect of N-Shh. Moreover, IRE1α-deficient MEFs exhibited elevated levels of osteogenic markers.Conclusions: Our findings suggest that the IRE1α-mediated unfolded protein response may alleviate the ossification of MEFs by attenuating Shh signaling. Our research has identified a strategy to inhibit excessive ossification, which may have clinical significance in preventing temporomandibular joint bony ankylosis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between periodontal disease and malignant soft tissue sarcomas. 牙周病与恶性软组织肉瘤的关系

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-08 DOI: 10.1111/odi.14853

Takatoshi Hiroshimaya, Yusuke Fujimoto, Hiromi Sasaki, Toshihiro Motoi, Emi Nagata, Noboru Taniguchi, Takahiko Oho

{"title":"Association between periodontal disease and malignant soft tissue sarcomas.","authors":"Takatoshi Hiroshimaya, Yusuke Fujimoto, Hiromi Sasaki, Toshihiro Motoi, Emi Nagata, Noboru Taniguchi, Takahiko Oho","doi":"10.1111/odi.14853","DOIUrl":"10.1111/odi.14853","url":null,"abstract":"Objective: Malignant soft tissue sarcoma (MSTS) is a rare disease, but is seen in patients undergoing orthopedic surgery. Although the association of periodontal disease with various cancers occurring in the oral cavity, gastrointestinal tract, lungs, and prostate, has been reported, the association between periodontal disease and MSTS remains unclear. This study investigated the association between periodontal disease and MSTS in patients undergoing orthopedic surgery.Subjects and methods: One hundred fifteen patients who underwent orthopedic surgery between 2017 and 2021 were retrospectively enrolled (mean age = 66.8 ± 10.7 years). The patient background was adjusted by the propensity score (PS). Subsequently, the association of periodontal disease with MSTS was analyzed using PS inverse probability of treatment weighting (IPTW). Periodontal status was determined by evaluating the periodontal inflamed surface area, which was calculated by measuring the periodontal probing pocket depth and detecting bleeding on probing.Results: Multivariate logistic regression analysis after adjustment by the PS showed that severe periodontitis was significantly associated with MSTS (odds ratio 2.81, p = 0.04). Furthermore, IPTW showed that severe periodontitis was significantly associated with MSTS (odds ratio 3.21, p = 0.01).Conclusion: The results indicate an association between periodontal inflammation and MSTS.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of differentiated dysplasia as a variant of oral epithelial dysplasia. 诊断分化性发育不良是口腔上皮发育不良的一种变异。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-08 DOI: 10.1111/odi.14846

Anne-Sophie Becker, Maximiliane Holm, Jan Liese, Nadja Engel, Annette Helene Zimpfer

{"title":"Diagnosis of differentiated dysplasia as a variant of oral epithelial dysplasia.","authors":"Anne-Sophie Becker, Maximiliane Holm, Jan Liese, Nadja Engel, Annette Helene Zimpfer","doi":"10.1111/odi.14846","DOIUrl":"10.1111/odi.14846","url":null,"abstract":"Objectives: The World Health Organization's definition of oral epithelial dysplasia includes differentiated dysplasia, which is defined by purely architectural abnormalities of oral mucosa without cytological changes. We analysed differentiated dysplasia's frequency, progression risk and correlation with oral brush cytology.Materials and methods: Cytoarchitectural criteria and expression patterns of keratin 13/17 and ki67 were studied in oral biopsies clinically diagnosed with leukoplakia. Biopsies were assessed for dysplasia and its grade. Available brush cytology findings were obtained from clinical records.Results: We included 159 biopsies from 112 patients (33% differentiated dysplasia; 27% keratosis without dysplasia; oral epithelial dysplasia with atypia of mild, moderate and severe degree including invasive cancers in 9%, 8% and 7%, respectively). Keratin 13 loss and keratin 17 gain were higher in differentiated-dysplasia cases (p < 0.0001), which had the highest hypergranulosis frequency. Keratin 17 expression was associated with higher malignant-transformation rates (p = 0.0028). The transformation rate and time were comparable between dysplasia with atypia and differentiated-dysplasia cases, which had higher progression rates and shorter time periods than keratosis cases without dysplasia (p = 0.08). Cytology prior to differentiated dysplasia all indicated normal oral mucosa.Conclusions: Keratin 17 but not oral brush cytology can help identify patients with differentiated dysplasia with higher risk for malignant transformation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study". 放疗或化放疗后造成植入物损失的潜在因素。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14889

Erkan Topkan, Efsun Somay, Uğur Selek

引用次数: 0

Influence of oral condition on the quality of life of patients hospitalized for COVID-19. 口腔状况对 COVID-19 住院患者生活质量的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14881

Lara Ribeiro Feitosa Duailibe, Laise Nunes Rodrigues, Alanna Barros de Arruda, Robinson Sabino-Silva, Rayenne Augusta Mota Ferreira, Rudys Rodolfo de Jesus Tavarez, Cyrene Piazera Silva Costa, Meire Coelho Ferreira

引用次数: 0

Comment on "Role of DNA methylation-based mitotic ageing indices in oral cancer development and recurrence". 考虑表观遗传有丝分裂指数在口腔癌筛查和风险分层中的作用。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-03-25 DOI: 10.1111/odi.14940

Jamaji C Nwanaji-Enwerem

引用次数: 0

Eight EDA mutations in Chinese patients with tooth agenesis and genotype-phenotype analysis. 中国牙齿缺失患者的八种EDA基因突变及基因型-表型分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-29 DOI: 10.1111/odi.14878

Kang Yu, Yihan Sheng, Feng Wang, Shuwen Yang, Futang Wan, Ming Lei, Yiqun Wu

{"title":"Eight EDA mutations in Chinese patients with tooth agenesis and genotype-phenotype analysis.","authors":"Kang Yu, Yihan Sheng, Feng Wang, Shuwen Yang, Futang Wan, Ming Lei, Yiqun Wu","doi":"10.1111/odi.14878","DOIUrl":"10.1111/odi.14878","url":null,"abstract":"Objective: Tooth agenesis is a common craniofacial malformation, which is often associated with gene mutations. The purpose of this research was to investigate and uncover ectodysplasin A (EDA) gene variants in eight Chinese families affected with tooth agenesis.Methods: Genomic DNA was extracted from tooth agenesis families and sequenced using whole-exome sequencing. The expression of ectodysplasin A1 (EDA1) protein was studied by western blot, binding activity with receptor was tested by pull-down and the NF-κB transcriptional activity was analyzed by Dual luciferase assay.Results: Eight EDA missense variants were discovered, of which two (c.T812C, c.A1073G) were novel. The bioinformatics analysis indicated that these variants might be pathogenic. The tertiary structure analysis revealed that these eight variants could cause structural damage to EDA proteins. In vitro functional studies demonstrated that the variants greatly affect protein stability or impair the EDA-EDAR interaction; thereby significantly affecting the downstream NF-κb transcriptional activity. In addition, we summarized the genotype-phenotype correlation caused by EDA variants and found that EDA mutations leading to NSTA are mostly missense mutations located in the TNF domain.Conclusion: Our results broaden the variant spectrum of the EDA gene associated with tooth agenesis and provide valuable information for future genetic counseling.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0