Oral diseases最新文献_第6页

Family Impact of Burning Mouth Syndrome: A Cross-Sectional Study Using FROM-16. 灼口综合征的家庭影响：使用FROM-16的横断面研究。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-21 DOI: 10.1111/odi.70478

Mona Jullie Hajj, Nicholas Sotak, Alessandro Villa, Alan Roger Santos-Silva, Lloyd Mancl, Thaís Cristina Esteves-Pereira, Milda Chmieliauskaite

{"title":"Family Impact of Burning Mouth Syndrome: A Cross-Sectional Study Using FROM-16.","authors":"Mona Jullie Hajj, Nicholas Sotak, Alessandro Villa, Alan Roger Santos-Silva, Lloyd Mancl, Thaís Cristina Esteves-Pereira, Milda Chmieliauskaite","doi":"10.1111/odi.70478","DOIUrl":"https://doi.org/10.1111/odi.70478","url":null,"abstract":"Background: Burning mouth syndrome (BMS) is a chronic oral pain condition associated with psychological distress and reduced quality of life. Although BMS' impact on patients is documented, family member impact remains poorly understood. This study evaluated family impact using Family Reported Outcome Measure (FROM-16), explored family burden associations, assessed FROM-16 domains, and identified unmet support needs.Methods: This cross-sectional study included 26 patient-family member dyads from an oral medicine clinic. Family burden was assessed using FROM-16. Open-ended responses were analyzed thematically to characterize family experiences and support needs. Associations between family burden and demographic/clinical variables were explored using nonparametric analyses.Results: Median total FROM-16 score was 5.5. Emotional burden exceeded personal/social burden, with worry, sadness, and frustration most common. Disruptions in family activities, eating habits, and family expenses were main social concerns. Lower household income was associated with higher burden scores. Qualitative findings confirmed emotional strain, altered social behaviors, and financial stress. Knowledgeable healthcare providers were the primary support source, although unmet healthcare, mental health, social, and treatment needs persisted.Conclusions: BMS affects families through emotional distress, disrupted eating habits, and social activities. These preliminary findings support evaluation of family-centered multidisciplinary approaches to improve support for patients and families.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply "Comparison of Ultrasound-Guided Versus Traditional Landmark-Based Joint Lavage and Intra-Articular Injection for TMD: A Randomized Controlled Trial". 作者回复“超声引导与传统地标性关节灌洗和关节内注射治疗TMD的比较：一项随机对照试验”

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-17 DOI: 10.1111/odi.70414

Fangfang Xu, Hao Cui, Tingwei Han, Sina Ahmadi, Le Bai, Xiang Liang, Linyang Xie, Yuxin Gong, Tao Wang, Kun Qi, Junbo Tu, Sijia Na

引用次数: 0

Efficacy and Safety of TKI Plus PD-1/PD-L1 Versus Monotherapy in Advanced HNSCC: A Systematic Review and Meta-Analysis. TKI联合PD-1/PD-L1与单药治疗晚期HNSCC的疗效和安全性：一项系统综述和荟萃分析

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-17 DOI: 10.1111/odi.70464

Zhengyan Luo, Xiyu Hu, Dongtao Wang

{"title":"Efficacy and Safety of TKI Plus PD-1/PD-L1 Versus Monotherapy in Advanced HNSCC: A Systematic Review and Meta-Analysis.","authors":"Zhengyan Luo, Xiyu Hu, Dongtao Wang","doi":"10.1111/odi.70464","DOIUrl":"https://doi.org/10.1111/odi.70464","url":null,"abstract":"Background: PD-1/PD-L1 inhibitors are standard therapy for advanced head and neck squamous cell carcinoma (HNSCC), but benefit only a subset of patients. Combining tyrosine kinase inhibitors (TKIs) with immunotherapy may improve outcomes.Methods: Following PRISMA 2020, PubMed, Embase, Cochrane Library and Web of Science were searched through January 2026 for clinical trials of PD-1/PD-L1 inhibitor monotherapy or TKI combination therapy in advanced HNSCC. Primary and secondary outcomes were objective response rate (ORR), 1-year overall survival (OS), median OS, progression-free survival (PFS) and safety. Random-effects meta-analyses, risk-of-bias assessment and GRADE evaluation were performed.Results: Eleven trials including 1190 patients were analysed. Combination therapy achieved a higher pooled ORR than monotherapy (36.2% vs. 16.6%; odds ratio 2.79, 95% CI 1.89-4.12; p < 0.001). The pooled 1-year OS rate was also higher with combination therapy (63.8% vs. 37.8%). Median PFS ranged from 3.2 to 14.6 months with combination therapy and 1.8-3.0 months with monotherapy. Grade ≥ 3 adverse events, including hypertension, proteinuria and hand-foot syndrome, were more frequent but manageable.Conclusion: TKI plus PD-1/PD-L1 inhibition improves tumour response and may prolong survival, although evidence is limited by small early-phase studies, heterogeneity and cross-trial confounding.Systematic review registration: PROSPERO CRD1297918.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Oral Microbiome-Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms. 老年牙周炎的口腔微生物-炎症轴：新出现的免疫致病和系统机制。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-15 DOI: 10.1111/odi.70493

Jabborova Feruza, Masharipov Otajon, Mukimov Shaxobiddin, Afakova Mamura, Kubaev Aziz, Khakimova Nargiza, Zebiniso Alimova

{"title":"The Oral Microbiome-Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms.","authors":"Jabborova Feruza, Masharipov Otajon, Mukimov Shaxobiddin, Afakova Mamura, Kubaev Aziz, Khakimova Nargiza, Zebiniso Alimova","doi":"10.1111/odi.70493","DOIUrl":"https://doi.org/10.1111/odi.70493","url":null,"abstract":"Background: Periodontitis prevalence increases with age, yet \"elderly periodontitis\" is not merely cumulative plaque exposure. Aging remodels mucosal immunity, elevates chronic inflammation, and promotes senescent cell accumulation with pro-inflammatory secretory phenotypes.Objective: To critically evaluate the self-reinforcing oral microbiome-inflammaging axis in elderly periodontitis.Methods: Narrative synthesis of mechanistic studies, human cohorts, and preclinical models investigating interactions between oral microbial ecology, immunosenescence, cellular senescence, and inflammaging.Results: Dysbiotic biofilms deliver persistent pressure interpreted by aged immune-stromal networks with heightened inflammatory gain. Mechanistic studies implicate aging-sensitive TLR9 sensing, age-amplified inflammasome-linked macrophage responses to P. gingivalis, and senescent niches that potentiate inflammation. Microbes directly induce senescence programs, including epithelial senescence and exosome-mediated paracrine immune senescence. Systemically, periodontitis induces multi-organ frailty-like phenotypes, neuroinflammatory changes, persistent gut dysbiosis, and altered metabolomes despite local therapy.Conclusion: Elderly periodontitis represents a geroscience-relevant disorder where dysbiosis and biological aging jointly establish a self-sustaining inflammatory ecosystem. Priority gaps include longitudinal elderly cohorts integrating microbiome function with senescence markers and stratified trials combining biofilm control with host modulation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O-GlcNAcylation: A Metabolic-Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation. o - glcn酰化：调节巨噬细胞命运和破骨细胞分化的代谢免疫中枢。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-15 DOI: 10.1111/odi.70498

Jing Zhang, Kun Tian, Nan Zhuang, Xin-Kui Zhang, Yan-Ling Zhang

{"title":"O-GlcNAcylation: A Metabolic-Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation.","authors":"Jing Zhang, Kun Tian, Nan Zhuang, Xin-Kui Zhang, Yan-Ling Zhang","doi":"10.1111/odi.70498","DOIUrl":"https://doi.org/10.1111/odi.70498","url":null,"abstract":"Background: O-GlcNAcylation is a dynamic and reversible post-translational modification of serine/threonine residues on cytoplasmic and nuclear proteins. Although it has been implicated as a \"differentiation switch and functional regulator\" in osteoclast biology, a systematic synthesis of its role across the macrophage-osteoclast axis and its contribution to bone remodeling disorders has not been elucidated.Methods: The present study examines evidence on O-GlcNAc cycling in macrophage polarization, RANKL signaling amplification, and the maintenance of the osteoclast transcriptional program. The analysis integrates findings from cellular and molecular studies with clinical evidence from diseases such as osteoporosis, inflammatory bone destruction, and tumor bone metastasis to provide a comprehensive overview of the underlying mechanisms.Results: O-GlcNAcylation is emerging as a pivotal regulator that disrupts bone remodeling equilibrium through multiple interconnected mechanisms along the macrophage-osteoclast axis. It promotes polarization of pro-inflammatory macrophages, amplifies RANKL-mediated signaling cascades, and stabilizes the transcriptional programs that drive osteoclast differentiation and function.Conclusion: O-GlcNAc glycosylation may provide a novel approach for restoring bone homeostasis in skeletal diseases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruscogenin Targets TXNIP to Suppress PANoptosis and Inflammation in Periodontitis. Ruscogenin靶向TXNIP抑制牙周炎PANoptosis和炎症。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-15 DOI: 10.1111/odi.70402

Jiaxin Huang, Zheng Zheng, Yao Li, Yan Xu, Lu Li

{"title":"Ruscogenin Targets TXNIP to Suppress PANoptosis and Inflammation in Periodontitis.","authors":"Jiaxin Huang, Zheng Zheng, Yao Li, Yan Xu, Lu Li","doi":"10.1111/odi.70402","DOIUrl":"https://doi.org/10.1111/odi.70402","url":null,"abstract":"Objective: This study explored the role of PANoptosis, a coordinated form of regulated cell death, in periodontitis (PD), aiming to identify key PANoptosis-related genes and evaluate potential small-molecule inhibitors.Methods: PANoptosis activity in periodontal tissues was assessed using ssGSEA. Differentially expressed PANoptosis-related genes were identified from GEO datasets (GSE10334, GSE16134). GO/KEGG enrichment, WGCNA, and multiple machine-learning methods were used to screen hub genes, followed by ROC validation and confirmation in clinical samples. Molecular docking and molecular dynamics simulations were performed to identify compounds targeting TXNIP. Single-cell RNA-seq was used to localize gene expression in immune subsets. Cell experiments examined TXNIP-mediated PANoptosis signaling, and a mouse PD model was used to verify inflammatory responses and tissue destruction in vivo.Results: TXNIP was identified as a key PANoptosis-associated gene broadly expressed in gingival cells and linked to PANoptosis activation. Ruscogenin was predicted and validated to suppress TXNIP-related PANoptosis and periodontal inflammation.Conclusions: TXNIP acts as an important PANoptosis-associated regulator in PD, while ruscogenin shows therapeutic promise by inhibiting TXNIP-related inflammatory cell death, providing new insight into PANoptosis mechanisms in PD progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontal Therapy-Related Changes in Clinical Parameters, Active-Matrix Metalloproteinase-8 and C-Reactive Protein in Prediabetes and Diabetes. 糖尿病前期和糖尿病患者牙周治疗相关临床参数、活性基质金属蛋白酶-8和c反应蛋白的变化

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-15 DOI: 10.1111/odi.70481

Kehinde Adesola Umeizudike, Olayiwola Ibrahim Olaoye, Ayodele Charles Ogundana, Ismo T Räisänen, Solomon Olusegun Nwhator, Babatunde Yusuf Alli, Patricia Omowunmi Ayanbadejo, Olufemi Adetola Fasanmade, Timo Sorsa

{"title":"Periodontal Therapy-Related Changes in Clinical Parameters, Active-Matrix Metalloproteinase-8 and C-Reactive Protein in Prediabetes and Diabetes.","authors":"Kehinde Adesola Umeizudike, Olayiwola Ibrahim Olaoye, Ayodele Charles Ogundana, Ismo T Räisänen, Solomon Olusegun Nwhator, Babatunde Yusuf Alli, Patricia Omowunmi Ayanbadejo, Olufemi Adetola Fasanmade, Timo Sorsa","doi":"10.1111/odi.70481","DOIUrl":"https://doi.org/10.1111/odi.70481","url":null,"abstract":"Objectives: This study investigated the effect of nonsurgical periodontal therapy (NSPT) on periodontal clinical parameters, active-matrix metalloproteinase-8 (aMMP-8), high sensitivity C-reactive protein (hsCRP), and glycated hemoglobin (HbA1c), and their relationships in diabetes and prediabetes patients with periodontitis.Materials and methods: In this prospective single-arm, interventional (before-and-after) study, 77 Nigerian periodontitis patients with diabetes (n = 45) and prediabetes (n = 32) received NSPT. Clinical parameters [periodontal inflamed surface area (PISA), Plaque Index (PLI), Gingival Index (GI)], mouthrinse aMMP-8, serum hsCRP, and HbA1c were measured at baseline and 3 months posttreatment. Analyses included paired t-tests, Pearson correlation, and linear mixed effect models (p < 0.05).Results: Diabetes and prediabetes patients showed improvements in PISA, PLI, GI, aMMP-8, HbA1c (p < 0.001), and hsCRP (p = 0.001) 3 months post-NSPT. Diabetes patients maintained improvements, but hsCRP and HbA1c were insignificant in prediabetes. Diabetes participants had greater HbA1c reduction (-0.78%), while prediabetes participants had larger aMMP-8 decrease (-20.91 ng/mL). Obesity reduced aMMP-8 and PLI responses, with no sex effect. Several variables showed significant correlations.Conclusion: NSPT reduces systemic inflammation and improves glycemic control, particularly in diabetes. HbA1c responds best in diabetes, aMMP-8 in prediabetes. Mouthrinse aMMP-8 PoC test enables real-time periodontal monitoring and supports diabetes risk screening in dental and medical care.Trial registration: The registration number: PACTR202608587329540; Trial registry: Pan African Clinical Trials Registry (PACTR).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa". 评论“大疱性表皮松解症患者脱落的口腔细胞遗传不稳定性增加”。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-14 DOI: 10.1111/odi.70491

Antonio Silva, Gabriel Carvalhal de Aguiar, Patricia Ramos Cury, Jean Nunes Dos Santos, Daniel Araki Ribeiro

引用次数: 0

Comparison Between the Fonseca's Questionnaire and Clinical Evaluation in Temporomandibular Disorders Among Dental Students: A Cross-Sectional Study. 横截面研究：Fonseca问卷与临床评价在牙科学生颞下颌疾病中的比较。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-09 DOI: 10.1111/odi.70499

Valeria Mitro, Gabriele Monarchi, Massimiliano Gilli, Antonio Bimonte, Guido Lombardo, Stefano Pagano, Umberto Committeri, Angela Rosa Caso, Federica Sacchi, Antonio Tullio

{"title":"Comparison Between the Fonseca's Questionnaire and Clinical Evaluation in Temporomandibular Disorders Among Dental Students: A Cross-Sectional Study.","authors":"Valeria Mitro, Gabriele Monarchi, Massimiliano Gilli, Antonio Bimonte, Guido Lombardo, Stefano Pagano, Umberto Committeri, Angela Rosa Caso, Federica Sacchi, Antonio Tullio","doi":"10.1111/odi.70499","DOIUrl":"https://doi.org/10.1111/odi.70499","url":null,"abstract":"Background: Temporomandibular disorders (TMDs) are conditions with heterogeneous clinical presentations. Screening tools like the Fonseca's Anamnestic Index (FAI) are used to self-assess TMD symptoms. Agreement with objective findings remains debated. This study aimed to compare FAI with clinical evaluation.Materials and methods: One hundred and twenty-five dental students completed the FAI. Subsequently, an experienced maxillofacial surgeon performed standardized clinical examinations. TMDs were clinically classified as absent, muscular, articular, or mixed. Agreement between FAI and clinical diagnosis was evaluated using Cohen's kappa.Results: According to FAI, 22.4% of participants reported no TMD, 54.4% mild, 20.0% moderate, and 3.2% severe symptoms. Clinical examination identified TMD signs in 60.0% of students, with muscular dysfunction being the most prevalent. Among subjects classified as absent or mild by FAI, 35.4% showed clinical signs of TMD. Conversely, 6.9% of those with moderate/severe self-reported symptoms showed no objective dysfunction. Overall agreement between subjective and clinical assessments was moderate, with a Cohen's kappa of 0.56 (95% CI: 0.42-0.71, p < 0.001).Conclusions: FAI is a useful tool for TMDs but shows only moderate concordance with clinical evaluation and may fail to detect objective signs that are not accompanied by reported symptoms. The integration of self-reported measures with professional clinical assessment is essential for accurate diagnosis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of CBCT-Derived Radiomics and Machine Learning to the Characterization of Osteolytic Lesions of the Jaws. cbct衍生放射组学和机器学习对颌骨溶解性病变表征的贡献。

IF 3.1 3区医学

Oral diseases Pub Date : 2026-09-09 DOI: 10.1111/odi.70462

Pierluigi Mariani, Francesco Fanelli, Diana Russo, Tiziano Maddalena, Angela Tisci, Giuseppe Troiano, Luigi Laino

{"title":"Contribution of CBCT-Derived Radiomics and Machine Learning to the Characterization of Osteolytic Lesions of the Jaws.","authors":"Pierluigi Mariani, Francesco Fanelli, Diana Russo, Tiziano Maddalena, Angela Tisci, Giuseppe Troiano, Luigi Laino","doi":"10.1111/odi.70462","DOIUrl":"https://doi.org/10.1111/odi.70462","url":null,"abstract":"Objective: Osteolytic jaw lesions are heterogeneous and share radiographic features. Radiomics from CBCT may provide quantitative biomarkers to aid differential diagnosis between developmental and inflammatory Odontogenic Cysts.Methods: A retrospective radiomic analysis was performed on CBCT scans of osteolytic jaw lesions from 52 patients; after quality control, 44 lesions were included (28 developmental and 16 inflammatory cysts). Lesions were segmented in 3D Slicer, and radiomic features were extracted with PyRadiomics. Unsupervised analyses used K-means and principal component analysis (PCA). Group differences were tested with ANOVA. For supervised classification, Logistic Regression, Random Forest, SVM, Multilayer Perceptron, and a stacking model were trained using PCA-based dimensionality reduction, mutual-information feature selection, SMOTE oversampling, and repeated stratified 5-fold cross-validation.Results: One thousand four hundred and thirty-seven features per lesion were extracted; univariate analysis identified 11 radiomic features showing differences between the two diagnostic groups (p < 0.05). However, none remained statistically significant after false discovery rate (FDR) correction, indicating the exploratory nature of these findings. Random Forest showed the best performance (AUC 0.76, accuracy 0.74, specificity 0.81, sensitivity 0.61). Unsupervised clustering did not reveal separated groups.Conclusions: While individual radiomic features did not demonstrate significance, a multivariate machine learning approach may identify complex signatures with moderate discriminative performance.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0