Oral diseases最新文献_第6页

Extracellular Vesicles From LPS-Treated PDLSCs Induce NLRP3 Inflammasome Activation in Periodontitis. 脂多糖处理的PDLSCs细胞外囊泡诱导牙周炎NLRP3炎性体激活。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15210

Yeke Wu, Jiawei Li, Min Liu, Ranran Gao, Hongling Zhou, Qiongying Hu, Lixing Zhao, Yunfei Xie

{"title":"Extracellular Vesicles From LPS-Treated PDLSCs Induce NLRP3 Inflammasome Activation in Periodontitis.","authors":"Yeke Wu, Jiawei Li, Min Liu, Ranran Gao, Hongling Zhou, Qiongying Hu, Lixing Zhao, Yunfei Xie","doi":"10.1111/odi.15210","DOIUrl":"https://doi.org/10.1111/odi.15210","url":null,"abstract":"Objective: This study aimed to investigate the effects of lipopolysaccharide (LPS)-pretreated primary periodontal ligament stem cell (PDLSC)-derived extracellular vesicles (EVs) (L-PDLSC-EVs) on periodontitis.Materials and methods: PDLSCs were obtained from mouse periodontal ligaments via enzymatic digestion. An in vitro inflammatory microenvironment for PDLSCs was established using LPS, and L-PDLSC-EVs were isolated through ultracentrifugation and identified. EVs from different treatments were co-incubated with RAW264.7 macrophages (Mφs) or periodontal ligament fibroblasts (PLFs) and their co-cultures, whereafter the biological behaviors in Mφs and PLFs were evaluated. Periodontitis mouse models were established to verify the role of L-PDLSC-EVs and the mechanisms involved.Results: There were no significant changes in the characteristics of L-PDLSC-EVs compared with control EVs. L-PDLSC-EVs promoted M1-type Mφ polarization and activated the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome. Furthermore, L-PDLSC-EVs promoted PLF cytotoxicity and apoptosis by enhancing the M1 polarization of Mφs. In periodontitis mouse models, L-PDLSC-EVs facilitated alveolar bone loss, PLF injury, and inflammatory responses, accompanied by an increased proportion of M1-type Mφs and reinforced NLRP3 inflammasome activation.Conclusions: L-PDLSC-EVs promoted PLF injury and exacerbated periodontitis through activating the NLRP3 inflammasome and promoting the polarization of M1-type Mφs, providing novel insights for the periodontitis progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review. 胶原基质与上皮下结缔组织对经济衰退覆盖率的系统评价。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-09 DOI: 10.1111/odi.15203

Alessandro Zangani, Miriana Gualtieri, Alessia Pardo, Annarita Signoriello, Paolo Faccioni, Gianluca Colapinto, Funda Goker, Giorgio Lombardo, Massimo Del Fabbro, Massimo Albanese

{"title":"Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review.","authors":"Alessandro Zangani, Miriana Gualtieri, Alessia Pardo, Annarita Signoriello, Paolo Faccioni, Gianluca Colapinto, Funda Goker, Giorgio Lombardo, Massimo Del Fabbro, Massimo Albanese","doi":"10.1111/odi.15203","DOIUrl":"https://doi.org/10.1111/odi.15203","url":null,"abstract":"Objective: To evaluate the outcome of collagen matrix (CMX) compared with subepithelial connective tissue graft (SCTG) in gingival recession coverage (RC) surgery.Methods: Review protocol was registered in PROSPERO. The search was conducted on MEDLINE, Cochrane Library, and Scopus databases. Randomized studies comparing CMX versus. SCTG or CMX versus. covering procedures without any filling material, for class I recession treatment were included. Risk of bias assessment and quantitative analysis were performed.Results: Of 168 records, 11 randomized clinical trials were included. The meta-analysis revealed no statistically significant difference in terms of %RC (p = 0.37); there was a statistically significant difference in terms of recession reduction (p = 0.02) and keratinized tissue width (p = 0.03) in favor of SCTG cases. CMX showed a statistically significantly better result compared to no grafting, regarding %RC (p = 0.003) and keratinized tissue thickness (p < 0.0001). The duration of the intervention was significantly shorter for CMX than for SCTG (p < 0.0001).Conclusion: CMX can be considered a viable material, especially when a ΔKTt increase and a reduction of intervention duration is needed. The indications for the choice, however, may depend on the individual local condition. PROSPERO Registration: Registration in PROSPERO (International prospective register of systematic reviews): CRD42024555443.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulomatous ulcer affecting the hard and soft palate in a young patient. 一个年轻病人的软硬腭肉芽肿性溃疡。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-06 DOI: 10.1111/odi.15127

Isabel Schausltz Pereira Faustino, Leonardo Dos Santos Bayeh, Danillo Batista Silveira, Irineu Maia, Joab Cabral Ramos

引用次数: 0

Schwann Cell-Mediated M2-Like Macrophage Polarization in Rhabdomyosarcoma. 横纹肌肉瘤中雪旺细胞介导的m2样巨噬细胞极化。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-05 DOI: 10.1111/odi.15214

Guanying Feng, Yibo Guo, Mingtao Chen, Yu Zhang, Zheqi Liu, Chen Sun, Xin Hu, Chengzhong Lin, Yu Liu, Yue Wu, Hao Wu, Xi Yang, Yang Wang, Jinhai Ye, Jiannan Liu, Xu Wang, Tong Ji, Chenping Zhang

{"title":"Schwann Cell-Mediated M2-Like Macrophage Polarization in Rhabdomyosarcoma.","authors":"Guanying Feng, Yibo Guo, Mingtao Chen, Yu Zhang, Zheqi Liu, Chen Sun, Xin Hu, Chengzhong Lin, Yu Liu, Yue Wu, Hao Wu, Xi Yang, Yang Wang, Jinhai Ye, Jiannan Liu, Xu Wang, Tong Ji, Chenping Zhang","doi":"10.1111/odi.15214","DOIUrl":"https://doi.org/10.1111/odi.15214","url":null,"abstract":"Objective: To investigate the cellular components and immunological characteristics of the head and neck rhabdomyosarcoma (RMS) microenvironment.Methods: We conducted single-cell transcriptomics to analyze the cellular components of the RMS microenvironment. CellChat was utilized for analyzing intercellular interactions. The cancer genome atlas database was used for validation. CIBERSORT was applied for immune infiltration profiling. Functional enrichment analyses were performed using the Kyoto Encyclopedia of Genes and Genomes. Gene set scores were calculated using single-sample gene set enrichment analysis. Subcutaneous allograft models and bulk RNA sequencing were used for validation. Flow cytometry and immunohistochemistry were used to identify M2-like macrophages.Results: Our findings revealed an extremely low presence of neutrophils in RMS samples compared with normal sample. RMS sample with high Schwann cell infiltration exhibited an increase in M2-like macrophage infiltration. Receptor-ligand pairs, specifically MIF-CD74 and PTN-SDC3, were identified between Schwann cells and M2-like macrophages. In the RMS sample characterized by significant Schwann cell infiltration, M2-like macrophages demonstrate robust expression of axon guidance factors and are enriched in the axon guidance pathway.Conclusions: Our study provides valuable insights into the microenvironment and immunological characteristics of RMS, offering crucial information for further research and potential therapeutic strategies.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taste Perception and Saliva Composition Are Not Altered in Burning Mouth Syndrome. 灼口综合征患者的味觉和唾液成分未发生改变。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-03 DOI: 10.1111/odi.15201

Marina Kolkka, Satu Jääskeläinen, Heli Forssell, Auli Suominen, Tuija Teerijoki-Oksa, Vuokko Loimaranta, Merja A Laine, Mari Sandell

{"title":"Taste Perception and Saliva Composition Are Not Altered in Burning Mouth Syndrome.","authors":"Marina Kolkka, Satu Jääskeläinen, Heli Forssell, Auli Suominen, Tuija Teerijoki-Oksa, Vuokko Loimaranta, Merja A Laine, Mari Sandell","doi":"10.1111/odi.15201","DOIUrl":"https://doi.org/10.1111/odi.15201","url":null,"abstract":"Objectives: To study the connections between burning mouth syndrome (BMS) and taste perception and saliva, and interactions between saliva and taste in BMS patients compared to age- and gender-matched control subjects.Materials and methods: A total of 31 BMS patients (43-82 years) and 20 age- and gender-matched volunteers (44-78 years) participated. The taste sensation for six tastants was measured using both the taste strips protocol and the whole-mouth evaluation method. Stimulated saliva was collected for 5 min. Salivary flow rate, pH, electrolyte concentrations (sodium, potassium, and calcium), MUC5B, MUC7, dehydroepiandrosterone (DHEA), and total protein were measured.Results: No differences were found between the groups in taste, salivary flow rate, or composition. A weak association between saliva composition and taste modalities was found within both groups. Metallic taste phantom was reported only by BMS patients (p = 0.03).Conclusions: In contrast to most previous reports, BMS patients did not differ from control subjects in any of the six taste modalities tested nor did the salivary variables differ between the groups. The relationship between salivary variables and total taste score was weak but similar in both groups. Further research with larger study samples is needed to confirm these results.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Treatment-Induced Head and Neck Malignancies in Cancer Survivors. 在癌症幸存者中导航治疗诱导的头颈部恶性肿瘤。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-01 DOI: 10.1111/odi.15213

Fábio Muradás Girardi, Gustavo Guthmann Pesenatto, Larissa Dill Fuchs, Thomas Peter Maahs, Nathaniel S Treister, Gerson Schulz Maahs

引用次数: 0

Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer. 国际肿瘤萌芽共识会议建议对口腔癌的影响。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-12-01 DOI: 10.1111/odi.15215

Katerina Kopecka, Michal Herman, Jaroslav Michalek, Jana Zapletalova, Marketa Hermanova, Priska Liptakova, Michal Hendrych, Michal Mozola, Richard Pink

{"title":"Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer.","authors":"Katerina Kopecka, Michal Herman, Jaroslav Michalek, Jana Zapletalova, Marketa Hermanova, Priska Liptakova, Michal Hendrych, Michal Mozola, Richard Pink","doi":"10.1111/odi.15215","DOIUrl":"https://doi.org/10.1111/odi.15215","url":null,"abstract":"Objectives: Tumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.Materials and methods: The study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.Results: Significant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.Conclusions: The ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study. 中国颅面和口腔畸形谱系的多中心研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-27 DOI: 10.1111/odi.15207

Xiaohong Duan, Yulong Zhu, Shuguo Zheng, Yaling Song, Wenmei Wang, Dong Chen, Zhenjin Zhao, Yongchu Pan, Zhuo Chen, Tingting Zhang, Yongqing Huang, Liling Ren, Dandan Ma, Weihong Wang, Shengbin Huang, Qinggao Song, Baisheng Wang, Yan Zheng, Jiang Li, Jianhua Wang, Yanli Zhang, Xinyue Guo, Wenyan Ruan, Jing Wang, Zhongcheng Gong, Xiaofeng Chang, Zhenglin Yuan, Fu Wang, Guangqing Tian, Jing Meng, Zhexuan Bao, Lin Li

{"title":"Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study.","authors":"Xiaohong Duan, Yulong Zhu, Shuguo Zheng, Yaling Song, Wenmei Wang, Dong Chen, Zhenjin Zhao, Yongchu Pan, Zhuo Chen, Tingting Zhang, Yongqing Huang, Liling Ren, Dandan Ma, Weihong Wang, Shengbin Huang, Qinggao Song, Baisheng Wang, Yan Zheng, Jiang Li, Jianhua Wang, Yanli Zhang, Xinyue Guo, Wenyan Ruan, Jing Wang, Zhongcheng Gong, Xiaofeng Chang, Zhenglin Yuan, Fu Wang, Guangqing Tian, Jing Meng, Zhexuan Bao, Lin Li","doi":"10.1111/odi.15207","DOIUrl":"https://doi.org/10.1111/odi.15207","url":null,"abstract":"Objective: Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we aimed to define the spectrum of COMs and analysis its features or possible influencing factors to improve the surveillance and control of the disease.Materials and methods: We organized a multicenter survey of COMs from 19 hospitals in 14 provinces. The clinical data of COM cases were collected from the electronic medical records system, cleaned and aggregated for analysis.Results: A total of 90,895 COM cases with 76 types of diseases were identified from 34,649,545 hospital population. The four most common COMs were supernumery teeth (62.64%), cleft lip and palate (28.53%), microdontia (2.86%), and tooth agenesis (1.70%). The remaining 72 diseases were detected in 3881 cases and were considered to be rare COMs. Moreover, 84.72% of rare COMs also manifested as other malformations or dysfunctions of the bone, skin and other tissues.Conclusions: COMs exhibit age and gender distribution patterns, have multiple types, and significant dental malformations. The diagnostic criteria and registration practices for COMs influence their reported prevalence and temporal trends, necessitating future improvements.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder. 口腔潜在恶性疾病的抗核阳性和恶性转化潜能。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15208

Seok Woo Hong, Jeong-Hyun Kang

{"title":"Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder.","authors":"Seok Woo Hong, Jeong-Hyun Kang","doi":"10.1111/odi.15208","DOIUrl":"https://doi.org/10.1111/odi.15208","url":null,"abstract":"Objective: This multicenter cohort study aimed to investigate the impact of antinuclear antibody (ANA) positivity on the malignant transformation potential of oral potentially malignant disorders (OPMDs) using the Observational Health Sciences and Informatics network tools for the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).Materials and methods: Retrospective cohort data from five medical centers were analyzed. Cox regression and 1:4 propensity score matching followed by aggregated meta-analysis were used to evaluate association between ANA positivity and the risk of oral squamous cell carcinoma (OSCC). The index date was defined as the first day of diagnosis of OPMD. The target and comparator cohorts comprised patients who tested positive and negative for ANA within 180 days before or after the index date, respectively.Results: Among 27,984 OPMD patients, 1302 patients (4.65%) confirmed malignant transformation. Among these, 3035 patients had ANA laboratory data. After 1:4 PS matching, 523 and 1598 patients with positive and negative for ANA were analyzed. Meta-analysis of the hazard ratios demonstrated that ANA positivity significantly increased the risk of malignant transformation compared to ANA negativity.Conclusions: ANA positivity is a significant prognostic marker for predicting malignant transformation in patients with OPMD.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZNF331 Represses the Proliferation of Head and Neck Squamous Cell Carcinoma via Co-Repressor TRIM28. ZNF331 通过协同抑制因子 TRIM28 抑制头颈部鳞状细胞癌的增殖

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15209

Ju Li, Hao Cheng, Yong Zhao, Yunkang Wang, Chen Gong, Renguo Gong, Yan Li

{"title":"ZNF331 Represses the Proliferation of Head and Neck Squamous Cell Carcinoma via Co-Repressor TRIM28.","authors":"Ju Li, Hao Cheng, Yong Zhao, Yunkang Wang, Chen Gong, Renguo Gong, Yan Li","doi":"10.1111/odi.15209","DOIUrl":"https://doi.org/10.1111/odi.15209","url":null,"abstract":"Objective: This study aims to explore the regulatory effect of Zinc Finger Protein 331 (ZNF331), a KRAB domain-containing transcriptional repressor, in Head and Neck Squamous Cell Carcinoma (HNSCC).Materials and methods: Data from The Cancer Genome Atlas (TCGA)-HNSC were analyzed. The roles of ZNF331 in HNSCC cell proliferation, cell cycle progression, and its interacting proteins were explored through in vitro manipulation of ZNF331 expression and in vivo xenograft experiments. The epigenetic mechanisms underlying ZNF331 dysregulation were investigated by assessing its promoter methylation and the effects of DNA methyltransferase (DNMT) knockdown.Results: Patients with higher ZNF331 expression had a significantly improved progression-free interval (PFI). ZNF331 overexpression inhibits HNSCC cell proliferation and induces G2/M arrest, while its knockdown enhances oncogenic features. ZNF331 can downregulate the expression of oncogenes such as DDX5, EIF5A, and SET. ZNF331's tumor-suppressive activity requires TRIM28, a universal co-repressor of KRAB-ZNF proteins. ZNF331 expression is suppressed by DNMT3B-mediated promoter hypermethylation. Selective knockdown of DNMT3B, but not DNMT3A, restored ZNF331 expression.Conclusions: ZNF331 acts as a potential tumor suppressor in HNSCC, whose inactivation through DNMT3B-mediated hypermethylation may contribute to HNSCC tumorigenesis. Restoring ZNF331 expression through targeted epigenetic therapies may offer a novel strategy for the treatment of HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0