New Insights Into Diffuse Sclerosing Osteomyelitis: Is There a Role of ANA and Vitamin B6?

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-04 DOI:10.1111/odi.70028

Katharina Theresa Obermeier, Tim Hildebrandt, Ina Dewenter, Wenko Smolka, Eric Hesse, Philipp Poxleitner, Sven Otto

{"title":"New Insights Into Diffuse Sclerosing Osteomyelitis: Is There a Role of ANA and Vitamin B6?","authors":"Katharina Theresa Obermeier, Tim Hildebrandt, Ina Dewenter, Wenko Smolka, Eric Hesse, Philipp Poxleitner, Sven Otto","doi":"10.1111/odi.70028","DOIUrl":null,"url":null,"abstract":"Object: Diffuse sclerosing osteomyelitis is a poorly understood chronic disease, which appears predominantly in the mandible. Female patients are more often affected than men. DSO is an ultra-rare disease and incidence is unknown; diagnosis can be very challenging; pathogenesis is poorly understood.Subjects and methods: In this prospective study, blood samples were collected from a total of 25 patients and analyzed to detect altered laboratory values to have insight into possible pathomechanism. Patients were divided into three groups: Group A: patients with DSO, Group B: patients with osteomyelitis and medication-related osteonecrosis, and Group C: healthy control group.Results: 44% of all patients in group A had elevated Vitamin B6 levels. Compared to groups B and C, these levels were statistically significantly higher (p = 0.011, p = 0.015). 23 patients had increased (92%) antinuclear-antibody-titer (ANA-Titer); in group B, 52% of all patients, and in the healthy control group, 44%.Conclusions: Elevated ANA titers and elevated vitamin B6 levels provide a possible insight into the pathomechanisms of DSO. Therefore, in the search for the pathogenesis and etiology of DSO, autoimmune processes should also be considered.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.70028","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Object: Diffuse sclerosing osteomyelitis is a poorly understood chronic disease, which appears predominantly in the mandible. Female patients are more often affected than men. DSO is an ultra-rare disease and incidence is unknown; diagnosis can be very challenging; pathogenesis is poorly understood.

Subjects and methods: In this prospective study, blood samples were collected from a total of 25 patients and analyzed to detect altered laboratory values to have insight into possible pathomechanism. Patients were divided into three groups: Group A: patients with DSO, Group B: patients with osteomyelitis and medication-related osteonecrosis, and Group C: healthy control group.

Results: 44% of all patients in group A had elevated Vitamin B6 levels. Compared to groups B and C, these levels were statistically significantly higher (p = 0.011, p = 0.015). 23 patients had increased (92%) antinuclear-antibody-titer (ANA-Titer); in group B, 52% of all patients, and in the healthy control group, 44%.

Conclusions: Elevated ANA titers and elevated vitamin B6 levels provide a possible insight into the pathomechanisms of DSO. Therefore, in the search for the pathogenesis and etiology of DSO, autoimmune processes should also be considered.

查看原文本刊更多论文

弥漫性硬化性骨髓炎的新认识：ANA和维生素B6是否有作用？

目的：弥漫性硬化性骨髓炎是一种主要发生在下颌骨的慢性疾病，目前对其了解甚少。女性患者比男性更容易受到影响。DSO是一种极为罕见的疾病，发病率尚不清楚；诊断非常具有挑战性；发病机制尚不清楚。对象和方法：在这项前瞻性研究中，共收集了25例患者的血液样本，并对其进行了分析，以检测实验室值的变化，从而深入了解可能的病理机制。患者分为三组：A组为DSO患者，B组为骨髓炎及药物相关性骨坏死患者，C组为健康对照组。结果：A组44%的患者维生素B6水平升高。与B组和C组相比，这些水平具有统计学意义（p = 0.011, p = 0.015）。抗核抗体滴度（ANA-Titer）升高23例（92%）；B组为52%，健康对照组为44%。结论：ANA滴度升高和维生素B6水平升高为DSO的病理机制提供了可能的见解。因此，在寻找DSO的发病机制和病因时，还应考虑自身免疫过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.