Oral diseases最新文献_第7页

Dysphagia and Dysphonia After Head and Neck Cancer. 头颈癌术后吞咽困难和发音障碍。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15152

Aaron Parsons, Karuna Dewan

{"title":"Dysphagia and Dysphonia After Head and Neck Cancer.","authors":"Aaron Parsons, Karuna Dewan","doi":"10.1111/odi.15152","DOIUrl":"https://doi.org/10.1111/odi.15152","url":null,"abstract":"Objective: The purpose of this work is to synthesize the latest developments in diagnosis and management of acute and late dysphagia and dysphonia in oral cavity cancer.Methods: A literature search was conducted using PubMed, Web of Science, Embase and Google Scholar in May 2024 of articles published between 2021 and 2024. Keywords in the search terms included oral cavity cancer, dysphagia, dysphonia, deglutition, swallowing, voice, oral cavity cancer treatment, oral cavity radiation, chemotherapy, dysgeusia, xerostomia, swallow preservation.Results: Twenty-seven pertinent studies fit the inclusion criteria. The most common dysphagic complaints following head and neck cancer are trismus, xerostomia, mucositis and dysphagia. Dysphonia, change in voice is reported by half of head and neck cancer survivors. Fibrosis and neuropathy following radiation therapy to the oral cavity, tongue, oropharynx and its surrounding structures is the most common etiology of post-treatment dysphonia.Conclusions: Oral cavity cancers cause speech and swallowing dysfunction due to both anatomic and post-treatment changes. These sequalae can be detrimental to the quality of life of the head and neck cancer survivor. For both dysphagia and dysphonia after head and neck cancer early speech and swallow therapy with a Speech Language Pathologist are essential to restoring and maintaining function.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of D₃K₂ With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients. D3K2 对糖尿病和 I-II 期牙周炎患者牙周治疗的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15147

Tolga Aydogan, Meltem Karsiyaka Hendek, Berrin Unsal, Aydın Çifci, Hakan Varol, Uçler Kisa, Ebru Olgun

{"title":"Effects of D3K2 With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients.","authors":"Tolga Aydogan, Meltem Karsiyaka Hendek, Berrin Unsal, Aydın Çifci, Hakan Varol, Uçler Kisa, Ebru Olgun","doi":"10.1111/odi.15147","DOIUrl":"https://doi.org/10.1111/odi.15147","url":null,"abstract":"Background: The aim of this study is to look into the clinical and biochemical outcomes of D3K2 supplementation in addition to nonsurgical periodontal treatment (NSPT) for patients suffering from diabetes mellitus (DM) and periodontitis.Methods: Thirty-eight participants with DM and periodontitis were randomized into two different groups. The test group provided NSPT with D3K2 whereas the control group received NSPT with placebo. Clinical periodontal parameters were recorded and serum and gingival crevicular fluid (GCF) were sampled at baseline and at the third and the sixth months after treatment. Glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 25(OH)D3, parathyroid hormone (PTH), calcium (Ca) and magnesium (Mg) values were determined in blood samples. GCF and serum interleukin (IL)-1β and IL-10 levels were analyzed using enzyme-linked immunosorbent assay.Results: All clinical periodontal parameters were importantly decreased at the third and sixth months after treatment compared to baseline in both groups. At the sixth month, 25(OH)D3 levels in the test group were observed to be statistically significantly higher than in the control group (p = 0.02). Serum IL-1β showed a statistically significant decrease at the sixth month compared to baseline and the third month in control group.Conclusion: According to this study, there is limited additional benefit of D3K2 given with NSPT in individuals with DM and periodontitis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nomogram to Predict Nodal Recurrence-Free Survival in Early Oral Squamous Cell Carcinoma. 预测早期口腔鳞状细胞癌无结节复发生存期的提名图

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15141

Ying Liu, Limin Liu, Yining He, Wen Jiang, Tianyi Fang, Yingying Huang, Xinyu Zhou, Dongwang Zhu, Jiang Li, Laiping Zhong

{"title":"Nomogram to Predict Nodal Recurrence-Free Survival in Early Oral Squamous Cell Carcinoma.","authors":"Ying Liu, Limin Liu, Yining He, Wen Jiang, Tianyi Fang, Yingying Huang, Xinyu Zhou, Dongwang Zhu, Jiang Li, Laiping Zhong","doi":"10.1111/odi.15141","DOIUrl":"https://doi.org/10.1111/odi.15141","url":null,"abstract":"Objective: This study aimed to develop and internally validate a prognostic nomogram for predicting nodal recurrence-free survival (NRFS) in patients with early-stage oral squamous cell carcinoma (OSCC) with clinically negative neck lymph nodes.Materials and methods: The management of early-stage oral cancer patients with clinically negative neck lymph nodes (cN0) remains controversial, especially concerning the need for elective neck dissection. Data from a single institution spanning 2010 to 2020 were utilized to develop and evaluate the nomogram. The nomogram was constructed using multivariable Cox regression and LASSO regression analyses to identify independent risk factors for lymph node metastasis. Internal validation was performed using bootstrap resampling to assess the nomogram's predictive accuracy.Results: A total of 930 cN0 patients with T1 and T2 stage OSCC were randomly divided into training and validation cohorts (8:2 ratio). Independent risk factors for lymph node metastasis included tumor pathological grade (well: reference, moderate/poor: OR 1.69), cT (cT1: reference, cT2: OR 2.01), history of drinking (never: reference, current/former: OR 1.72), and depth of invasion (0 mm < DOI ≤ 5 mm: reference, 5 mm < DOI ≤ 10 mm: OR 1.31). The nomogram, incorporating these variables, demonstrated good predictive accuracy with a C-index of 0.67 (95% CI: 0.58-0.76) in the validation set. In both training and validation groups, the nomogram effectively stratified patients into low-risk and high-risk groups for occult cervical nodal metastases (p < 0.05).Conclusions: The nomogram enables risk stratification and improved identification of occult cervical nodal metastases in clinically node-negative OSCC patients by incorporating tumor-specific and patient-specific risk factors.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The psychosocial background of dental care avoidance: A qualitative study. 逃避牙科护理的社会心理背景：一项定性研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15136

Márton Lukács, Balázs Fábián, Antal Bugán, István Varga

{"title":"The psychosocial background of dental care avoidance: A qualitative study.","authors":"Márton Lukács, Balázs Fábián, Antal Bugán, István Varga","doi":"10.1111/odi.15136","DOIUrl":"https://doi.org/10.1111/odi.15136","url":null,"abstract":"Introduction: Dental care avoidance affects individuals' oral health status. There is limited literature examining the context of dental avoidance behavior.Aim: The aim of the study is to examine attitudes toward dental care services among adults.Methods: Overall, 16 patients participated in semi-structured interviews. The interviews were analyzed using inductive thematic analysis. Through independent reviews of the themes that comprise the patients' experience, a consensus was established among the researchers.Results: Ten major themes were identified that encapsulate patients' attitudes toward dental care attendance: Effect of environment and equipment, Fear and anesthesia, Procrastination, Dissatisfaction with the dental care system, Expectations of dentists, Quality of dental care, Edentulousness and social status, Financial involvement, Aesthetics, and Dentists' behavior. Compliance with oral health maintenance can be enhanced by specific training for professionals and dentistry students and by fine tuning the dental care system.Conclusions: This is the first comprehensive study in Hungary investigating attitudes among dentist patients toward dental care. The results suggest that there are many factors that may affect dental care attendance. Thus, these findings make a potentially fundamental contribution to the improvement of dental care and support practitioners in enriching their understanding of dental avoidance behavior.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oropharyngeal Adverse Events to Drugs and Vaccines: Pharmacovigilance Data From Italy (2019-2021). 药物和疫苗的口咽部不良事件：意大利药物警戒数据（2019-2021 年）》。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15145

Liberata Sportiello, Gaetano La Mantia, Vera Panzarella, Giuseppe Colella, Simona Potenza, Giacomo Oteri, Laura Sottosanti, Giuseppe Bellavia, Mario Gaio, Alessia Zinzi, Ilaria Morreale, Gaspare Parrinello, Elisabetta Geninatti, Eleonora Marrazzo, Vittorio Fusco, Annalisa Capuano, Giuseppina Campisi

{"title":"Oropharyngeal Adverse Events to Drugs and Vaccines: Pharmacovigilance Data From Italy (2019-2021).","authors":"Liberata Sportiello, Gaetano La Mantia, Vera Panzarella, Giuseppe Colella, Simona Potenza, Giacomo Oteri, Laura Sottosanti, Giuseppe Bellavia, Mario Gaio, Alessia Zinzi, Ilaria Morreale, Gaspare Parrinello, Elisabetta Geninatti, Eleonora Marrazzo, Vittorio Fusco, Annalisa Capuano, Giuseppina Campisi","doi":"10.1111/odi.15145","DOIUrl":"10.1111/odi.15145","url":null,"abstract":"Objectives: The aim of this study was to perform a descriptive analysis of oropharyngeal adverse events (AEs) related to drugs and/or vaccines in order to provide useful information for clinicians.Methods: Data related to three regions of Italy were analyzed from 2019 to 2021 by using the National Pharmacovigilance database.Results: Among overall 67,384 cases, 2773 (4.1%) reported at least one oropharyngeal AE. Most cases referred to females (71.0%) and adults (70.8%). The majority of cases were reported as not serious (68.4%) and the outcome was mainly positive (73.5%). The cases related to drugs (52.2%) were slightly more than those related to vaccines (47.8%), the latter nearly completely represented by COVID-19 vaccines. Among 3324 oropharyngeal AEs, the most commonly reported were oropharyngeal conditions (65.9%). The most reported AEs related to vaccines were paresthesia oral and oropharyngeal pain, whereas the most reported AEs related to drugs were throat tightness and angioedema. A marked under-reporting of osteonecrosis of the jaw (2.9%) was observed, despite this risk was well documented in the same country.Conclusions: This analysis suggested an under-reporting of oropharyngeal AEs and the need to better train dentists, dental hygienists, and also general practitioners.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification. 基于 2022 年世界卫生组织分类的 4777 例囊肿和牙源性肿瘤的流行病学特征。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-06 DOI: 10.1111/odi.15146

Victoria Rees, Matías Klare, Valentina Samaniego, Felipe Leiva, René Jara, Benjamín Martínez Rondanelli, Sergio González Providell

{"title":"Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification.","authors":"Victoria Rees, Matías Klare, Valentina Samaniego, Felipe Leiva, René Jara, Benjamín Martínez Rondanelli, Sergio González Providell","doi":"10.1111/odi.15146","DOIUrl":"https://doi.org/10.1111/odi.15146","url":null,"abstract":"Objective: The epidemiology of cysts and odontogenic tumors is important for differential diagnosis and treatment strategies. We aimed to describe the epidemiological features of cysts and odontogenic tumors in the Chilean population using the current WHO classification.Materials and methods: We reviewed 22,914 biopsy requests received between January 1984 and September 2023 at the oral pathology department, School of Dentistry, Universidad Mayor, Santiago, Chile. Patients diagnosed with cysts of the jaws and odontogenic tumors were selected and information regarding age, sex, and location was recorded.Results: 4226 (18.4%) were cysts, and 551 (2.4%) were odontogenic tumors, ranging from 2 to 97 years old. Males represented 54.4% and females 45.7% of the total sample. The most prevalent cysts were radicular cysts (58.6%), dentigerous cysts (17.9%), and odontogenic keratocysts (13.3%). The most prevalent odontogenic tumors were odontomas (40.1%) and conventional ameloblastoma (17.6%).Conclusions: Our study was the first retrospective analysis to determine the epidemiological features of both cysts and odontogenic tumors together, based on the 2022 WHO classification. This is relevant as it offers a potential basis for comprehensive comparisons of the epidemiological features of these entities, which could contribute to an accurate differential diagnosis, therefore, leading to more effective therapeutic interventions.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' reply "Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study". 回复编辑：放疗或化放疗后种植体损失的潜在因素。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14888

Jamie M Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A H J de Visscher, Max J H Witjes, Johannes A Langendijk, Gerry M Raghoebar

引用次数: 0

USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination. USP14 通过促进 SOX2 的去泛素化促进 OSCC 的癌干样细胞特性。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI: 10.1111/odi.14896

Chang Liu, Shijie Zhou, Wei Tang

{"title":"USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination.","authors":"Chang Liu, Shijie Zhou, Wei Tang","doi":"10.1111/odi.14896","DOIUrl":"10.1111/odi.14896","url":null,"abstract":"Objective: USP14 (Ubiquitin-specific-processing protease 14) is a deubiquitinating enzyme with oncogenic effects in oral squamous cell carcinoma (OSCC). This study aims to identify new substrates of USP14 and elucidate their role in modulating cancer stem-like cells (CSCs) in OSCC.Materials and methods: Bioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively. OSCC cell lines and patient-derived cells were used for experimental validation, employing co-immunoprecipitation, cycloheximide chase assays, and tumor sphere formation to evaluate the effects of USP14 on SOX2 stability, ubiquitination, and CSC phenotypes.Results: USP14 upregulation was associated with worse overall survival and progression-free interval in OSCC. USP14 interacted with SOX2 with its ubiquitin carboxyl-terminal hydrolase domain. USP14 knockdown impaired SOX2 stability by increasing its polyubiquitination. Ectopic overexpression of wild-type USP14, but not the hydrolase-deficient-mutant USP14C114A, enhanced SOX2 stability by reducing polyubiquitination. USP14 knockdown suppressed OSCC cell proliferation, colony formation, and tumor sphere formation in vitro and tumor growth in vivo. However, the reduction of CSC markers following USP14 knockdown was mitigated by overexpressing SOX2. These findings were verified in OSCC patient-derived CSC cells.Conclusion: This study revealed a USP14-SOX2 axis regulating the CSC properties of OSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4255-4265"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRE1α inhibits osteogenic differentiation of mouse embryonic fibroblasts by limiting Shh signaling. IRE1α 通过限制 Shh 信号抑制小鼠胚胎成纤维细胞的成骨分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1111/odi.14919

Zhixiang Zhang, Xuan Zhang, Xiangzhen Wei, Chengbo Yu, Li Xiao, Jianmiao Liu, Yong Liu, Yingguang Cao, Ke Song

{"title":"IRE1α inhibits osteogenic differentiation of mouse embryonic fibroblasts by limiting Shh signaling.","authors":"Zhixiang Zhang, Xuan Zhang, Xiangzhen Wei, Chengbo Yu, Li Xiao, Jianmiao Liu, Yong Liu, Yingguang Cao, Ke Song","doi":"10.1111/odi.14919","DOIUrl":"10.1111/odi.14919","url":null,"abstract":"Objectives: This study aimed to investigate the effect of endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) on the sonic hedgehog N-terminus (N-Shh)-enhanced-osteogenic differentiation process in mouse embryonic fibroblasts (MEFs).Materials and methods: Osteogenesis of MEFs was observed by alkaline phosphatase (ALP) staining, alizarin red staining, and Von Kossa staining assays. Activation of unfolded protein response and Shh signaling were examined using real-time quantitative PCR and western blot assays. IRE1α-deficient MEFs were used to explore the effect of IRE1α on N-Shh-driven osteogenesis.Results: N-Shh increased ALP activity, matrix mineralization, and the expression of Alp and Col-I in MEFs under osteogenic conditions; notably, this was reversed when combined with the ER stress activator Tm treatment. Interestingly, the administration of N-Shh decreased the expression of IRE1α. Abrogation of IRE1α increased the expression of Shh pathway factors in osteogenesis-induced MEFs, contributing to the osteogenic effect of N-Shh. Moreover, IRE1α-deficient MEFs exhibited elevated levels of osteogenic markers.Conclusions: Our findings suggest that the IRE1α-mediated unfolded protein response may alleviate the ossification of MEFs by attenuating Shh signaling. Our research has identified a strategy to inhibit excessive ossification, which may have clinical significance in preventing temporomandibular joint bony ankylosis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"4504-4517"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of chatbot-generated references in the field of oral oncology: Exercising caution. 聊天机器人生成的口腔肿瘤学领域参考文献的准确性：谨慎行事。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-22 DOI: 10.1111/odi.14880

Gargi S Sarode, Sachin C Sarode, Shruti Singh, Amol Dhane

引用次数: 0