Oral diseases最新文献

{"title":"Is It Worth to Investigate Serum Zinc Level in Patients With Recurrent Aphthous Stomatitis: A Case-Control Study.","authors":"Jirapat Luchsameekankha, Natcha Yoongkeiw, Nannaphatsorn Charoenthanakasaem, Chayapon Ittitanakul, Jay Saepoo, Kanokporn Pangsomboon","doi":"10.1111/odi.70442","DOIUrl":"https://doi.org/10.1111/odi.70442","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOX2 As a Biomarker of Pathological Response in Oral Cavity Squamous Cell Carcinoma Treated With Neoadjuvant Chemotherapy: A Retrospective Cohort Study.","authors":"Aishwarya Sharma, Najinder Preet Kaur, Rasheeda Mohamedali, Heena Gupta, Nitika Gupta, Aratrika Sau, Pranab Dey, Puneet Somal, Nilay Nishith, Ravikiransingh Pawar, Sankalp Sancheti, Prabhat Ganju, Sahil Sood, Pragyat Thakur, Sahil Mittal, Latika Kansal","doi":"10.1111/odi.70496","DOIUrl":"https://doi.org/10.1111/odi.70496","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemotherapy response is highly variable in locally advanced oral cavity squamous cell carcinoma. SOX2, a stemness-associated transcription factor, promotes chemoresistance through cancer stem cell maintenance. No prior study has evaluated pretreatment SOX2 protein expression as a predictor of pathological response to neoadjuvant chemotherapy in this disease. We present the first retrospective evaluation of this question, assessed against the Hirakawa tumour regression grading system.</p><p><strong>Methods: </strong>Fifty-four patients with locally advanced oral cavity squamous cell carcinoma receiving neoadjuvant chemotherapy followed by curative surgery were analysed retrospectively. SOX2 immunohistochemistry was performed on paired pre- and post-treatment specimens in 47 patients, defined as the primary analytic cohort. Pathological response was graded using the Hirakawa tumour regression grading system. Kaplan-Meier and Cox proportional hazards analyses were performed for event-free and overall survival. Subgroup analyses stratified by NACT regimen were additionally performed.</p><p><strong>Results: </strong>SOX2 negativity was significantly associated with a favourable pathological response (odds ratio 6.22, 95% confidence interval 1.32-29.29, p = 0.021), with a negative predictive value of 82.4%. This association was directionally consistent across NACT subgroups, which did not differ significantly in pathological response or survival. Good responders demonstrated significantly superior event-free survival (p = 0.006). Nodal metastasis was the dominant independent predictor of event-free survival on multivariate Cox analysis (hazard ratio 6.23, p = 0.026).</p><p><strong>Conclusions: </strong>SOX2 negativity at baseline is associated with a favourable neoadjuvant chemotherapy response in locally advanced oral cavity squamous cell carcinoma. The Hirakawa tumour regression grading system demonstrated strong prognostic discrimination for event-free survival. Prospective, externally validated evaluation of SOX2 within a multi-marker prediction panel is warranted; these findings should be regarded as hypothesis-generating pending such validation.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Expression of Cyclin B1 and Cytoplasmic HMGB1 Is Associated With Delayed Cervical Lymph Node Metastasis in Early-Stage Tongue Squamous Cell Carcinoma.","authors":"Wataru Kakuguchi, Aya Yanagawa-Matsuda, Nako Maishi, Takehiro Chida, Kenta Takahashi, Shoko Kirikoshi, Kyoko Hida, Yuichi Ashikaga, Yoichi Ohiro","doi":"10.1111/odi.70476","DOIUrl":"https://doi.org/10.1111/odi.70476","url":null,"abstract":"<p><strong>Objective: </strong>Delayed cervical lymph node metastasis is strongly associated with poor prognosis in early-stage tongue squamous cell carcinoma, but useful biomarkers remain limited. This study evaluated cyclin B1, high-mobility group box protein 1 and 2, and proliferating cell nuclear antigen for stratifying the risk of delayed cervical lymph node metastasis.</p><p><strong>Methods: </strong>Eighty-two patients with Stage I/II tongue squamous cell carcinoma who underwent partial glossectomy without elective neck dissection were included. Cyclin B1 and the cytoplasmic expression of the other three markers were assessed immunohistochemically. Cutoff values were determined using receiver operating characteristic analysis. Cervical lymph node metastasis-free survival was estimated using Kaplan-Meier and multivariable Cox analyses.</p><p><strong>Results: </strong>Cyclin B1 showed the strongest association with delayed cervical lymph node metastasis (χ² = 29.0, p < 0.0001; area under the curve, 0.80; sensitivity, 84.0%; specificity, 77.2%). Dual positivity for cyclin B1 and cytoplasmic high-mobility group box protein 1 showed 76.0% sensitivity and 87.7% specificity and remained significantly associated with metastasis-free survival after adjustment for pathological depth of invasion and Yamamoto-Kohama classification (adjusted hazard ratio, 8.57; 95% confidence interval, 3.44-24.36; p < 0.0001).</p><p><strong>Conclusions: </strong>Combined cyclin B1 and cytoplasmic high-mobility group box protein 1 assessment may aid postoperative risk stratification.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Treatment-Related Weight Changes With Functional Impairments, Public Visits, and Future Life Perspectives in Oral Cancer: A Multicenter Study.","authors":"Efthymios Papazacharias, Max Lukas Linderkamp, Stephan Alexander Bettag, Anij von der Gracht, Rijahd Sahmer Boustani, Jan Gaessler, Thomas Lewandowski, Fritjof Lentge, Michael-Tobias Neuhaus, Gertrud Krüskemper, Nils-Claudius Gellrich, Philippe Korn, Philipp Jehn","doi":"10.1111/odi.70495","DOIUrl":"https://doi.org/10.1111/odi.70495","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate treatment-related weight changes in oral cancer and examine their association with functional impairments, public visits, and future life perspectives.</p><p><strong>Materials and methods: </strong>Data from 1359 surgically treated patients were retrospectively analyzed in a multicenter rehabilitation study conducted by the German-Austrian-Swiss Cooperative Group on Tumors of the Maxillofacial Region (DÖSAK). Weight changes were self-reported after treatment using a standardized questionnaire. Associations with tumor stage, surgical treatment, functional impairments, public visits, and future life perspectives were analyzed.</p><p><strong>Results: </strong>Weight loss was significantly associated with advanced tumor stage (p = 0.001), nodal metastasis (p < 0.001), and radical neck dissection (p = 0.038). Weight differences alone did not change patients' public visits compared with the past (p < 0.001). However, weight loss combined with functional impairments in eating (p < 0.001), speaking (p < 0.001), and physical appearance (p < 0.001) was associated with avoidance of public visits. Stable weight was associated with favorable future life perspectives, whereas weight loss was associated with negative future perspectives (p < 0.001).</p><p><strong>Conclusion: </strong>Early identification of treatment-related weight changes may help identify patients at risk of functional impairments and adverse psychosocial outcomes, supporting timely nutritional interventions in oral cancer care.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Histopathologic Parameters and Patterns of Invasion in Oral Squamous Cell Carcinoma and Their Correlation With Patient Survival.","authors":"Ana Mirian da Silva Cavalcante, Janderson Fernando da Silva, Tayane Oliveira Gonçalves, Fabrício Bitu Sousa, Erick Ibraim Carlos da Costa, Ana Paula Negreiros Nunes Alves, Jennifer Viana Barbosa, Dayrine Silveira de Paula, Paulo Goberlânio de Barros Silva, Thinali Sousa Dantas","doi":"10.1111/odi.70473","DOIUrl":"https://doi.org/10.1111/odi.70473","url":null,"abstract":"<p><strong>Introduction: </strong>Oral squamous cell carcinoma is the most prevalent malignant neoplasm in the head and neck region, and its prognosis is influenced by various histopathological and clinical factors. pTNM tumor staging and invasion patterns are fundamental for predicting therapeutic response and patient survival.</p><p><strong>Methods: </strong>A retrospective study analyzing 283 cases of oral squamous cell carcinoma treated at Haroldo Juaçaba Hospital. Histopathological and clinical information was collected, including tumor grade, pTNM, invasion pattern, and response to therapy. Statistical analyses were carried out in SPSS software using Fisher's tests, Pearson's chi-squared, log-rank Mantel-Cox, and Cox regression.</p><p><strong>Results: </strong>The presence of pN2/pN3 nodal metastases, compromised margins, and a history of smoking were associated with a worse prognosis. Adjuvant radiotherapy alone showed longer disease-free survival. Perineural invasion and a low stromal infiltrating lymphocyte score were significant negative prognostic factors. Multivariate analysis showed that patients with lymph node involvement (HR = 1.84; 95% CI: 1.02-3.31; p = 0.042) and stromal infiltrating lymphocytes (HR = 0.44; 95% CI: 0.21-0.089; p = 0.022) had an increased risk of recurrence.</p><p><strong>Conclusion: </strong>Lymph node involvement and low lymphocyte infiltration are determining factors for tumor recurrence, as are the presence of comorbidities, alcohol, and smoking, reinforcing the need for continuous monitoring and personalized therapies.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: \"Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches\".","authors":"Masoumeh Daneshian, Lars Fredriksson, Pia Skott, Karin Garming Legert","doi":"10.1111/odi.70483","DOIUrl":"https://doi.org/10.1111/odi.70483","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches\".","authors":"Mariam Amjad, Muhammad Faizan Khan","doi":"10.1111/odi.70490","DOIUrl":"https://doi.org/10.1111/odi.70490","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply \"Imaging and Pathology Concordance in Head and Neck Cancer: Retrospective Analysis\".","authors":"Bo Lin, Feng Wang, Shiyue Shen, Yufan Wang, Xia Hong, Xin Ye, Shunji Wang, Youdan Yao, Tianwen Zhang, Huijun Yang, Hongyu Yang","doi":"10.1111/odi.70485","DOIUrl":"https://doi.org/10.1111/odi.70485","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches\".","authors":"Giusy Rita Maria La Rosa, Gaetano Isola, Riccardo Polosa","doi":"10.1111/odi.70489","DOIUrl":"https://doi.org/10.1111/odi.70489","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Dysbiosis and Malignant Transformation of Oral Potentially Malignant Disorders: The Missing LPS-VEGF Link.","authors":"Lucas Alves da Mota Santana, Michelly Kierkigard Campos de Oliveira, Carlos Eduardo Palanch Repeke, Lysandro Pinto Borges, Wilton Mitsunari Takeshita, Gina Délia Roque-Torres","doi":"10.1111/odi.70487","DOIUrl":"https://doi.org/10.1111/odi.70487","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}