Oral diseases最新文献_第7页

Integrated Functional Care for Children With Congenital Zika Syndrome: Addressing Orofacial, Speech-Language, and Nutritional Needs. 先天性寨卡综合征儿童的综合功能护理：解决口腔、语言和营养需求。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-04 DOI: 10.1111/odi.70058

Paulo Ricardo Martins-Filho, Thales Rafael Correia de Melo Lima, Janiele de Sá Ferreira, Larissa Silva Souza, Cecília Bezerra de Meneses Corbal Guerra, Luiz Carlos Santos-Júnior, Raquel Souza Marques, Carolina Santos Souza Tavares, Brenda Carla Lima Araújo

引用次数: 0

The Dental Status of Patients Taking Common Biologic Agents: A Single-Center Cross-Sectional Study. 服用常用生物制剂患者的牙齿状况：一项单中心横断面研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-17 DOI: 10.1111/odi.15311

Shivani Shah, Nila Veerabagu, Nana A A Essel, Neda Mahjour, Katherine France

{"title":"The Dental Status of Patients Taking Common Biologic Agents: A Single-Center Cross-Sectional Study.","authors":"Shivani Shah, Nila Veerabagu, Nana A A Essel, Neda Mahjour, Katherine France","doi":"10.1111/odi.15311","DOIUrl":"10.1111/odi.15311","url":null,"abstract":"Objectives: Despite expanding use and medical applications, little is known about the impact of biologic agents (BAs) on dental treatment. The aim of this study was to investigate the dental status of patients on common classes of BAs to understand treatment needs and use in this population.Methods: A retrospective cross-sectional study was conducted on patients treated with the most common classes of BA (tumor necrosis factor-alpha [TNF-α] inhibitors, interleukin (IL) inhibitors, and lymphocyte modulators) from 1/7/2017 to 1/7/2022. Data on demographic factors, BA treatment, medical conditions including indication, restorative and periodontal treatments, and decayed, missing, and filled tooth index (DMFT) were compared descriptively.Results: The study identified 247 patients treated with 24 different BAs. Restorative and periodontal treatment was completed on 60.3% and 72.9% of patients, respectively. The DMFT scores were higher in the study cohort compared to the average US adult population. The analysis revealed an upward trend in both periodontal and restorative treatments.Conclusions: This study provides the first comprehensive characterization of the oral health status and treatment needs of patients taking BAs. The findings suggest a higher dental treatment burden in this population, particularly regarding restorative care in this population, a finding that may be confirmed or expanded in future evaluations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2641-2651"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data. 抗精神病药物的口服不良反应：eudravilance数据的病例/非病例分析

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1111/odi.15337

Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera-Herreras

{"title":"Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data.","authors":"Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera-Herreras","doi":"10.1111/odi.15337","DOIUrl":"10.1111/odi.15337","url":null,"abstract":"Objective: Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database.Methods: A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the disproportionality of oral adverse events.Results: A total of 5663 reports of oral adverse effects related to antipsychotics were identified. Atypical antipsychotics had a higher overall incidence (5663 vs. 787 for typical), but typical antipsychotics showed stronger associations with specific oral issues (ROR = 2.2 vs. 1.6 for atypical). The most commonly reported effects were disturbances in salivary flow, including xerostomia and hypersalivation. Olanzapine and quetiapine were linked to dry mouth (ROR = 1.8 and 3.0) and tooth loss (ROR = 1.7 and 1.8). Clozapine had the highest number of reports (1619) and ROR (33.1) for hypersalivation. Disproportionality analysis revealed significant associations with orofacial dyskinesia for all antipsychotics, except clozapine. Aripiprazole had the highest ROR (13.7) for orofacial dyskinesia and was linked to a swollen tongue in patients aged ≤ 17 years (12 cases, ROR = 3.6). No sex-based differences were identified.Conclusions: Antipsychotics significantly affect oral health, highlighting the need for preventive dental care and interventions to reduce these effects and improve patient well-being.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2630-2640"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply: "Association Between Metabolic Syndrome and Salivary MMP-8, MPO in Periodontitis". 作者回复：“牙周炎患者唾液MMP-8、MPO与代谢综合征的关系”。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1111/odi.15306

Julie Toby Thomas, Betsy Joseph, Sukumaran Anil, Tuomas Waltimo, Timo Sorsa

引用次数: 0

Teleconsultation Actions in Reducing In-Person Referrals for Oral Lesions: A Scoping Review. 远程会诊在减少口腔病变现场转诊中的作用：范围综述。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-18 DOI: 10.1111/odi.15314

Rebeka Thiara Nascimento Dos Santos, Jonathan França da Silva Cavalcanti, Luiz Gustavo de Sousa Duda Júnior, Ana Júlia Alves de Vasconcelos, Pamella Recco Alvares, Ana Paula Veras Sobral

{"title":"Teleconsultation Actions in Reducing In-Person Referrals for Oral Lesions: A Scoping Review.","authors":"Rebeka Thiara Nascimento Dos Santos, Jonathan França da Silva Cavalcanti, Luiz Gustavo de Sousa Duda Júnior, Ana Júlia Alves de Vasconcelos, Pamella Recco Alvares, Ana Paula Veras Sobral","doi":"10.1111/odi.15314","DOIUrl":"10.1111/odi.15314","url":null,"abstract":"Objectives: This scoping review aimed to investigate the impact of teleconsultation actions on the reduction of unnecessary referrals for specialized in-person care of oral lesions.Materials and methods: This review included studies on teleconsultation in oral medicine and oral pathology that presented data on the referral flow for in-person care. Teleconsultation modalities included synchronous, asynchronous, or unspecified interactions. Excluded from the review were: (1) reviews, clinical cases, letters, chapters, conference abstracts, and editorials; (2) studies on direct teleconsultation between professionals; (3) telemanagement interventions; and (4) tele-education initiatives.Results: Nine articles met the inclusion criteria. The asynchronous teleconsultation stands out as the most effective intervention for reducing in-person referrals, observed in eight studies. Referral reductions ranged from 37.3% to 80%, with five studies exceeding 50%. Primary healthcare dentists were the most frequent users of the teleconsultation platform. The most commonly identified lesions found were oral potentially malignant disorders and soft tissue tumors.Conclusion: Asynchronous teleconsultation may reduce referrals for in-person care, though evidence is limited. Notably, referral rates exhibited significant heterogeneity across studies. Low reduction rates may be attributed to the high proportion of cases requiring in-person assessment. Future research should focus on optimizing referral reduction while addressing the heterogeneity of outcomes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2404-2418"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FTO Promotes Osteogenic Differentiation of Human BMSCs via Demethylation of TGFB2 m⁶A Modifications. FTO通过TGFB2 m6A修饰的去甲基化促进人骨髓间充质干细胞成骨分化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI: 10.1111/odi.15324

Xingyang Li, Wanyi Chen, Wenchao Zhong, Lecheng Tan, Kaitong Deng, Wei Cao, Mingjing Zhu, Antong Wu, Ziyi Zhang, Yuzhuo Hei, Siqing Jiang, Xin Li, Rui Li, Wenyi Cai, Janak L Pathak, Qingbin Zhang

{"title":"FTO Promotes Osteogenic Differentiation of Human BMSCs via Demethylation of TGFB2 m6A Modifications.","authors":"Xingyang Li, Wanyi Chen, Wenchao Zhong, Lecheng Tan, Kaitong Deng, Wei Cao, Mingjing Zhu, Antong Wu, Ziyi Zhang, Yuzhuo Hei, Siqing Jiang, Xin Li, Rui Li, Wenyi Cai, Janak L Pathak, Qingbin Zhang","doi":"10.1111/odi.15324","DOIUrl":"10.1111/odi.15324","url":null,"abstract":"Objective: To elucidate the role of m6A modification in the osteogenic differentiation of human BMSCs (hBMSCs) and the underlying mechanisms.Materials & methods: In this research, we analyzed the m6A modification and its impact on mRNA expression and osteogenic differentiation of hBMSCs. FTO was knocked down in hBMSCs using shRNAs, and the effect on osteogenic differentiation was evaluated. m6A-seq was performed to identify key m6A-methylation mRNAs during osteogenic differentiation. TGFB2 was knocked down to validate its role in FTO-regulated m6A-methylation-mediated osteogenesis.Results: We found downregulated global m6A modification in osteogenically differentiating hBMSCs. m6A eraser FTO expression was upregulated during the osteogenic differentiation of hBMSCs. FTO knockdown inhibited the osteogenic differentiation of hBMSCs. Downregulation of mRNA m6A modification was prominent in osteogenically differentiating hBMSCs. mRNA m6A modifications in osteogenically differentiating hBMSCs were mainly attributed to MAPK, focal adhesion, and TGFβ signaling. Finally, we revealed that FTO demethylates m6A abundance of TGFB2, promoting the TGFB2 expression in hBMSCs. Knockdown of TGFB2 inhibited the osteogenic differentiation of hBMSCs.Conclusion: These results indicate that upregulated m6A eraser FTO downregulates m6A modifications promoting TGFB2 expression in hBMSCs that trigger osteogenic differentiation, suggesting activation of FTO or TGFB2 as a strategy to promote hBMSC-based bone defect repair.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2505-2517"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Genomics Using High-Throughput Methods for Salivary Analysis in Sjögren's Disease. 使用高通量方法进行Sjögren病唾液分析的功能基因组学

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1111/odi.15328

Giovanna P Florezi, Mônica Teresa Veneziano Labate, Carlos Alberto Labate, Felippe P Barone, Silvia Vanessa Lourenço

{"title":"Functional Genomics Using High-Throughput Methods for Salivary Analysis in Sjögren's Disease.","authors":"Giovanna P Florezi, Mônica Teresa Veneziano Labate, Carlos Alberto Labate, Felippe P Barone, Silvia Vanessa Lourenço","doi":"10.1111/odi.15328","DOIUrl":"10.1111/odi.15328","url":null,"abstract":"Objectives: Primary Sjögren's disease (SjD) is a slow-progressing autoimmune disease that affects salivary and lacrimal glands, causing dry eyes (xerophthalmia) and dry mouth (xerostomia). Diagnosing SjD involves clinical, serological, and histological assessments, but reliable biomarkers are lacking.Methods: This study analyzed the metabolic and proteomic profiles of 19 female SjD patients (based on ACR-EULAR criteria) compared to 20 healthy individuals. Saliva and blood samples were analyzed using mass spectrometry and chromatography. Proteomic analysis was performed with the nanoElute nanoflow system coupled to a timsTof-Pro mass spectrometer, and metabolic profiling with a GC-TOF/MS Pegasus HT.Results: Statistical tests identified significant differences in metabolites and proteins between SjD patients and controls. Metabolome analysis revealed changes in amino acid synthesis, purine and lipid metabolism, and exposure to external compounds. Proteomic analysis indicated immune-related proteins and inflammatory lipid metabolism. GNAI2, B2MG, NGAL, SLUR2, HS90, SODC, and A2GL emerged as potential biomarkers for SjD.Conclusion: This study demonstrates the potential of high-performance techniques in identifying biomarkers for SjD diagnosis and prognosis. Data are available via ProteomeXchange (PXD055629).","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2474-2486"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of Adjuvant Radiotherapy in pN1 OSCC Patients Without Adverse Pathologic Features. 辅助放疗在无不良病理特征的pN1型OSCC患者中的应用。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-02 DOI: 10.1111/odi.15336

Bo Li, Zhang Zhao, Yu Huang, Hanchen Zhou, Xue Zhang, Chuanbin Guo, Wei Wei, Na Ge, Wei Cao, Zhien Feng

{"title":"The Application of Adjuvant Radiotherapy in pN1 OSCC Patients Without Adverse Pathologic Features.","authors":"Bo Li, Zhang Zhao, Yu Huang, Hanchen Zhou, Xue Zhang, Chuanbin Guo, Wei Wei, Na Ge, Wei Cao, Zhien Feng","doi":"10.1111/odi.15336","DOIUrl":"10.1111/odi.15336","url":null,"abstract":"Purpose: This study aimed to assess the necessity of adjuvant radiotherapy for oral squamous cell carcinoma patients with a pN1 stage and no adverse pathological features.Patients and methods: This was a multicenter cohort study including 231 patients.Results: Among the enrolled patients, 171 received adjuvant radiotherapy, and 60 did not. According to the Kaplan-Meier survival analysis, there were no significant differences between the two groups in terms of disease-free survival (59.5% vs. 58.3%, p = 0.938), overall survival (73.1% vs. 75.0%, p = 0.936), and disease-specific survival (74.9% vs. 76.7%, p = 0.914). In patients with local/regional recurrence after surgery, after-recurrence survival (34.8% vs. 44.0%, p = 0.197) was not significantly different. Analysis by T stage revealed no significant differences in disease-free survival (60.9% vs. 75.0%, p = 0.084), overall survival (73.6% vs. 90.6%, p = 0.053) and disease-specific survival (75.8% vs. 90.6%, p = 0.072) for T1-2 patients between the radiotherapy and non-radiotherapy groups. The results revealed statistically significant differences in disease-free survival (57.9% vs. 39.3%, p = 0.030), overall survival (72.4% vs. 57.1%, p = 0.034) and disease-specific survival (73.7% vs. 60.7%, p = 0.049) between the two groups.Conclusions: Adjuvant radiotherapy does not improve the prognosis of T1-2N1M0 patients without adverse pathological features; however, adjuvant radiotherapy should be recommended for T3-4aN1M0 patients.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2466-2473"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study. 创伤性三叉神经病变的血清生物标志物及其临床相关性：一项初步研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-31 DOI: 10.1111/odi.15322

Hye-Kyoung Kim, Insoon Chang, Sung-Hoon Lee

{"title":"Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study.","authors":"Hye-Kyoung Kim, Insoon Chang, Sung-Hoon Lee","doi":"10.1111/odi.15322","DOIUrl":"10.1111/odi.15322","url":null,"abstract":"Objectives: This study aims to investigate the serum biomarker levels in patients with painful post-traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients.Materials and methods: A total of 32 patients with PPTTN were included. Serum levels of various cytokines and neurotrophic factors were measured. Patients were assessed for clinical and psychological characteristics, including pain severity, pain interference, numbness severity, and symptom duration as well as psychological factors using validated questionnaires.Results: No significant differences in serum biomarker levels were found based on age, sex, pain severity, pain interference, or type of injured nerve after adjusting multiple comparisons. Significant differences were observed in interleukin-8 (IL-8) and brain-derived neurotrophic factor (BDNF) levels based on symptom duration, with higher levels in patients whose symptoms lasted for more than 6 months. Spearman correlation analysis revealed strong relationships between clinical and psychological variables. Pain outcomes were more strongly associated with psychological factors than with serum biomarkers.Conclusion: IL-8 and BDNF may be biomarkers for disease progression in PPTTN based on symptom duration, with pain outcomes more related to psychological factors rather than serum biomarker levels, highlighting the need for psychological support in management.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"2584-2595"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postgraduate Satisfaction in Oral Pathology and Oral Medicine: Insights From Brazil. 口腔病理学和口腔医学研究生的满意度：巴西的启示

IF 2.9 3区医学

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-17 DOI: 10.1111/odi.15315

Luiz Miguel Ferreira, Marcos Paulo Maia-Lima, Samuel Trezena, Fabrício Emanuel Soares de Oliveira, Árlen Almeida Duarte, Daniella Reis Barbosa Martelli, Fábio de Abreu Alves, Roseana de Almeida Freitas, Jean Nunes Dos Santos, Maria Cassia Ferreira de Aguiar, Marcio Ajudarte Lopes, Paulo Rogério Ferreti Bonan, Janete Dias Almeida, Hercílio Martelli-Júnior

引用次数: 0