Oral diseases最新文献_第7页

Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease. 健康和疾病中颅面植入区微生物组和元蛋白质组。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15398

Daniela Lattuf Cortizo, Renato C V Casarin, Hélvis E S Paz, Camila S Stolf, Mabelle F Monteiro, Mônica T V Labate, Márcio Z Casati, Luciano Lauria Dib

{"title":"Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease.","authors":"Daniela Lattuf Cortizo, Renato C V Casarin, Hélvis E S Paz, Camila S Stolf, Mabelle F Monteiro, Mônica T V Labate, Márcio Z Casati, Luciano Lauria Dib","doi":"10.1111/odi.15398","DOIUrl":"https://doi.org/10.1111/odi.15398","url":null,"abstract":"Background: Craniofacial defects from cancer surgery led to functional, aesthetic, and psychological challenges. Rehabilitation with craniofacial implants addresses these issues by improving prosthesis retention through osseointegration and providing predictable cosmetic results. However, maintaining a healthy transcutaneous region is essential for implant longevity.Objective: Evaluation of the microbial community and host response around extraoral implants.Methods: In an intrasubject control study design, 12 cancer patients who had undergone oculofacial rehabilitation with implant-supported prostheses were included. Biofilm and peri-implant fluid samples were collected from the transcutaneous region of healthy and diseased implants. Microbiome profiling was conducted through DNA sequencing of the V3-V4 region of the 16S rRNA gene, and proteome analysis was performed using liquid chromatography-tandem mass spectrometry.Results: Differentially abundant species were observed, with Streptococcus intermedius being the most abundant in diseased areas, followed by Corynebacterium diphtheriae and Prevotella bivia. Metaproteomic analysis revealed distinct protein expression patterns between the groups, with increased activation of proinflammatory responses and inactivation of anti-inflammatory responses in the diseased group.Conclusion: The study demonstrated an increased abundance of pathogenic bacterial community accompanied by an imbalanced immune response, thereby highlighting host-microbial factors that can influence the success of osseointegration and facial rehabilitation.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker. Vimentin 3在成釉细胞瘤中的作用：一种新的肿瘤生物标志物。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15396

Sibel Elif Gultekin, Melanie von Brandenstein, Emre Baris, Ipek Atak Secen, Leyla Arslan Bozdag, Heike Goebel

{"title":"The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker.","authors":"Sibel Elif Gultekin, Melanie von Brandenstein, Emre Baris, Ipek Atak Secen, Leyla Arslan Bozdag, Heike Goebel","doi":"10.1111/odi.15396","DOIUrl":"https://doi.org/10.1111/odi.15396","url":null,"abstract":"Introduction: Ameloblastoma (ABL), a common odontogenic tumor in the maxillofacial region, presents primarily as unicystic (U-ABL) and conventional (C-ABL) variants. Despite shared epithelial features, their distinct biological behaviors may stem from interactions between connective tissue and epithelial cells. Vimentin 3 (VIM3), a truncated variant of Vimentin-Full Length (VIMFL), exhibits unique biological properties. This study is the first to investigate VIM3 expression in ABLs.Methods: Formalin-fixed paraffin-embedded (FFPE) samples of C-ABL (n = 30), U-ABL (n = 30), and dental follicles (DF, n = 30) were analyzed. Immunohistochemical evaluation of VIM3, VIMFL, WNT5a, and MTCO1 was performed, alongside qRT-PCR for VIM3, VIMFL, WNT5a, ROR2, and miR-498.Results: VIM3 expression was significantly higher in C-ABL (p < 0.0001) compared to U-ABL and DFs. VIMFL was absent in the epithelial components of all cases. C-ABL showed significantly higher WNT5a (p < 0.0001) and MTCO1 (p = 0.0327) expression. qRT-PCR revealed significant differences in VIM3 and miR-498 levels between U-ABL and DFs (p < 0.0001). No significant differences were found for WNT5a, VIMFL, or ROR2 (p > 0.05).Conclusion: This study identifies VIM3 expression in ABLs, distinct from VIMFL, suggesting its potential as a biomarker. Additionally, mitochondrial dysfunction may play a role in ABL tumorigenesis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized Controlled Trials for Oral Leukoplakia. 口腔白斑的随机对照试验。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-02 DOI: 10.1111/odi.15399

Michele Lodolo, Jack Valor, Alessandro Villa

引用次数: 0

Efficacy of Conservative Therapy in Juvenile Recurrent Parotitis: A Retrospective Study. 青少年复发性腮腺炎的保守疗法疗效：回顾性研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-30 DOI: 10.1111/odi.15240

Yanxiang Li, Shutong Niu, Zhiyuan He, Hanyi Zhu, Yimin Liu, Xin Bao, Chuangqi Yu, Huan Shi

{"title":"Efficacy of Conservative Therapy in Juvenile Recurrent Parotitis: A Retrospective Study.","authors":"Yanxiang Li, Shutong Niu, Zhiyuan He, Hanyi Zhu, Yimin Liu, Xin Bao, Chuangqi Yu, Huan Shi","doi":"10.1111/odi.15240","DOIUrl":"10.1111/odi.15240","url":null,"abstract":"Objective: The objective of this study is to evaluate the therapeutic effect of conservative treatment in children with juvenile recurrent parotitis (JRP).Methods: Clinical data from 55 children who were diagnosed with JRP from June 2019 to January 2022 were collected. On admission, patients underwent comprehensive examinations, and a questionnaire was completed by the patients and their parents. Patients received only conservative treatment, including sialagogues, warm compresses, massage and antibiotic treatment.Results: Episodes after treatment (1.11 ± 1.42) were significantly lower in 55 patients than before treatment (3.35 ± 2.42) (p < 0.001). Clinical symptoms improved for 81.81% and recurred for 60%. Patients who did not respond to treatment were in 3- to 5-year-old group. The serum IgG (p = 0.018), IgA (p = 0.014) and IgM (p = 0.032) levels in the nonresponsive group were significantly higher than those in the improvement group and were either higher than the normal range or at the upper limit. The improvement rate was positively related to the CD8%, and the serum IgA concentration was negatively related to the number of previsit episodes.Conclusion: Conservative treatment is effective for most children with JRP. Patient responses to treatment may be associated with the maturation of their immune systems. Underlying immune dysregulation should be evaluated, and further treatment is needed in severe cases.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1726-1734"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction Between Sclerostin and Mast Cells in Fibro-Osseous Lesions of the Jaws. 颌骨纤维骨化病变中硬骨素与肥大细胞之间的相互作用

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2024-12-30 DOI: 10.1111/odi.15232

Riéli Elis Schulz, Michel Calil Abrão-Neto, Thiago Pires Claudio, Vinícius Gonçalves de Souza, Elena Riet Correa Rivero, Rogério Oliveira Gondak, Gustavo Davi Rabelo

{"title":"Interaction Between Sclerostin and Mast Cells in Fibro-Osseous Lesions of the Jaws.","authors":"Riéli Elis Schulz, Michel Calil Abrão-Neto, Thiago Pires Claudio, Vinícius Gonçalves de Souza, Elena Riet Correa Rivero, Rogério Oliveira Gondak, Gustavo Davi Rabelo","doi":"10.1111/odi.15232","DOIUrl":"10.1111/odi.15232","url":null,"abstract":"Objective: To assess the sclerostin, β-catenin, and tryptase expression in fibro-osseous lesions (FOL) of the jaws.Subjects and methods: Immunohistochemistry analysis was performed for these proteins on FOL and non-lesional bone. The sclerostin-positive cells were scored from 0 (no expression) to 3 (high expression).Results: We analyzed 46 FOL biopsies and selected 38 patients. Categorization showed 15 fibrous dysplasia (FD), eight juvenile trabecular ossifying fibroma (JTOF), two psammomatoid ossifying fibroma (PsOF), and 13 FOL. We found more sclerostin-positive cells in fibrous tissue than in bone, showing a phenotype like mast cells with strong dot-cytoplasmic positivity. The analysis of sclerostin-positive cell lesions (scored as 2 and 3) showed also tryptase positivity in 80.9% of 21 biopsies. β-catenin was diffusely expressed on the fibrous component, mostly with cytosol staining. Non-lesional bone showed sclerostin expression in medullary spaces and a few osteocytes.Conclusions: Sclerostin-positive cells are mostly found in the fibrous tissue of FOL, and the tryptase mast cell marker was present in most of the lesions that were positive for sclerostin.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1823-1830"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering Disulfidptosis-Linked lncRNA Patterns as Potential HNSCC Biomarkers. 解读与二硫酸化相关的lncRNA模式作为潜在的HNSCC生物标志物。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1111/odi.15283

Qi Chen, Xiao Shi, Yuanyuan Bao, Yue Chen

{"title":"Deciphering Disulfidptosis-Linked lncRNA Patterns as Potential HNSCC Biomarkers.","authors":"Qi Chen, Xiao Shi, Yuanyuan Bao, Yue Chen","doi":"10.1111/odi.15283","DOIUrl":"10.1111/odi.15283","url":null,"abstract":"Background: Our investigation sought to uncover the intrinsic features of Head and Neck Squamous Cell Carcinoma (HNSCC), particularly the role of long non-coding RNAs implicated in disulfidptosis (DRLs).Materials and methods: We carried out lncRNA-mRNA RNA-Seq studies on HNSCC cells and harnessed the data from The Cancer Genome Atlas (TCGA), which includes 522 HNSCC tumors and 44 normal specimens. Bioinformatics evaluations aided in recognizing DRLs and estimating their prognostic value. Furthermore, we built a predictive model related to the chosen DRLs to scrutinize its linkage with the patients' prognosis. We also dug into tumor mutation loads and responses to chemotherapy.Results: Our study identified three key DRLs (LINC02434, AC245041.2, and LINC02762) with considerable correlation to HNSCC prognosis. The risk model, utilizing these DRLs, successfully categorized patients into high-risk and low-risk clusters, uncovering differential survival trajectories. Moreover, the same risk model conveyed unique prognostic potential in HNSCC. Surveying the tumor microenvironment unfolded disparities between the groups, hinting toward potential implications for tactics in immunotherapy. We recognized distinct chemotherapeutic drugs with fluctuating responses across the risk clusters and molecular categories.Conclusion: This investigation not only sheds light on prospective therapeutic pathways but also enhances our grasp of the molecular intricacies of HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1658-1671"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis. 肠道疾病与牙周炎的关系：一项系统综述和荟萃分析。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-02-10 DOI: 10.1111/odi.15260

Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye

{"title":"Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Yuebo Wu, Daozhi Ji, Xiaoqiu Chen, Lixin Wang, Fang Ye","doi":"10.1111/odi.15260","DOIUrl":"10.1111/odi.15260","url":null,"abstract":"Background: Despite evidence suggesting a potential correlation between intestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) with periodontitis (PD), there is a lack of comprehensive systematic reviews and meta-analyses to consolidate these findings.Methods: This study investigates studies published until December 31, 2023, in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. The statistical analysis was conducted using Review Manager Version 5.4, calculating odds ratios (OR) and 95% confidence intervals (CI) based on the selected research papers, utilizing a fixed-effects model.Results: It demonstrates a significant increase in the risk of PD among patients with IBD, as indicated by an OR of 2.11 (95% CI: 1.80-2.49). Further analysis revealed elevated risks of PD for both Crohn's disease (CD) and ulcerative colitis (UC), with respective ORs of 1.96 (95% CI: 1.69-2.26) and 2.14 (95% CI: 1.85-2.47). A direct association was observed between CRC and PD, suggesting a 20% higher risk of PD in patients with CRC (OR = 1.20, 95% CI: 1.06-1.36).Conclusion: Our meta-analysis highlights the potential role of PD in managing systemic conditions like IBD and CRC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1603-1625"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply "Effect of Adiposity Status on Salivary Streptococcus mutans and Streptococcus sobrinus." Oral Diseases. Advance Online Publication. https://doi.org/10.1111/odi.15111. 作者回复“肥胖状况对唾液变形链球菌和链球菌的影响”口腔疾病。提前在线出版。https://doi.org/10.1111/odi.15111。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-17 DOI: 10.1111/odi.15261

Qianyi Deng, Hai Ming Wong, Simin Peng

引用次数: 0

LIMA1 Is a Prognostic Senescence-Inhibitory Gene in Head and Neck Squamous Carcinoma. LIMA1是头颈部鳞状癌的预后衰老抑制基因。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-01-21 DOI: 10.1111/odi.15263

Yuanhe You, Zhong Du, Zhuowei Tian, Fan Yu, Shunshun Li, Jie He, Meng Xiao, Yanan Wang

{"title":"LIMA1 Is a Prognostic Senescence-Inhibitory Gene in Head and Neck Squamous Carcinoma.","authors":"Yuanhe You, Zhong Du, Zhuowei Tian, Fan Yu, Shunshun Li, Jie He, Meng Xiao, Yanan Wang","doi":"10.1111/odi.15263","DOIUrl":"10.1111/odi.15263","url":null,"abstract":"Background: This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head and neck squamous cell carcinoma.Methods: Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) and the Human Aging Genomic Resources (HAGR) database. Prognostic value and immune infiltration were assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK-8, Edu assay, and colony formation assays in vitro. Western blotting and real-time PCR were used to evaluate LIMA1 expression. Clinical validation of LIMA1 expression was performed in our validated cohort.Results: In this study, differential analysis and functional enrichment analysis identified 26 differentially expressed senescence inhibitory genes. Among them, LIMA1 was found to be an independent prognostic marker and associated immune infiltration. Knockdown of LIMA1 inhibited HNSCC cell growth and increased the expression of senescence markers. Further experiments revealed that LIMA1 expression was partially regulated by the IL6/STAT3 signaling pathway. Immunohistochemistry further validated the clinical significance of LIMA1 expression and its association with IL6 and CD8+ T cells in our hospital's HNSCC tissues.Conclusion: LIMA1 is a prognostic senescence-inhibitory gene in HNSCC. The IL6/STAT3/LIMA1 axis represents a novel molecular mechanism underlying cellular senescence resistance in HNSCC.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1692-1703"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferroptosis: A New Challenge and Target in Oral Diseases. 上睑下垂：口腔疾病的新挑战和新目标。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1111/odi.15303

Ruijie Jiao, Hu Long

{"title":"Ferroptosis: A New Challenge and Target in Oral Diseases.","authors":"Ruijie Jiao, Hu Long","doi":"10.1111/odi.15303","DOIUrl":"10.1111/odi.15303","url":null,"abstract":"Objective: Ferroptosis, an iron-dependent intracellular programmed cell death mechanism discovered in the last decade, has emerged as a novel and intriguing concept in oral diseases, distinct from apoptosis, necrosis, and pyroptosis. This process plays a critical role in the pathophysiology of inflammation, trauma, and tumors, with evidence of its presence in multiple organ systems, including the liver, kidneys, and heart. In recent years, many studies have found that ferroptosis is closely related to oral diseases, and a number of pathogenic pathways and therapeutic strategies have been reported. However, ferroptosis remains an underexplored area in oral diseases, with multiple secrets waiting to be uncovered.Method: We collected articles related to ferroptosis and oral diseases and analyzed the mechanisms and therapeutic strategies associated with ferroptosis in different oral diseases.Results: In this review, we present a comprehensive analysis of ferroptosis and oral diseases, emphasizing its core mechanisms and associated therapeutic approaches. Furthermore, we give an outlook for future explorations of ferroptosis related to oral diseases.Conclusion: This review provides dental researchers and clinicians with a current state of ferroptosis in oral diseases, thereby inspiring noval investigations and discoveries.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"1626-1636"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0