Oral diseases最新文献_第7页

New IPCL Classification Using NBI for Early Detection of OPMDs Malignant Transformation. 利用 NBI 进行新的 IPCL 分类，以早期发现 OPMDs 恶性转化。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-25 DOI: 10.1111/odi.15200

Yiming Xu, Tianyu Zhang, Dan Liu, Xuemei Qiu, Feifei Hou, Jiongke Wang, Xiaobo Luo, Hongxia Dan, Yu Zhou, Xing Zeng, Lu Jiang, Qianming Chen

{"title":"New IPCL Classification Using NBI for Early Detection of OPMDs Malignant Transformation.","authors":"Yiming Xu, Tianyu Zhang, Dan Liu, Xuemei Qiu, Feifei Hou, Jiongke Wang, Xiaobo Luo, Hongxia Dan, Yu Zhou, Xing Zeng, Lu Jiang, Qianming Chen","doi":"10.1111/odi.15200","DOIUrl":"https://doi.org/10.1111/odi.15200","url":null,"abstract":"Objectives: Introduce a new intrapapillary capillary loop (IPCL) classification using narrow-band imaging (NBI) to diagnose early malignant transformation in oral potentially malignant disorders (OPMDs).Methods: In the exploratory phase, NBI images from 241 patients with OPMDs and oral squamous cell carcinoma (OSCC) were assessed for three basic IPCL features-dilation, unevenness, and tortuosity-to identify patterns associated with OPMDs malignant transformation. Chi-square analysis and logistic regression differentiated these patterns between low-risk (no/mild dysplasia) and high-risk (moderate/severe dysplasia, invasive carcinoma) lesions, establishing a new classification system. In the validation phase, the system was applied to 90 patients with histopathological results confirming diagnostic accuracy.Results: Four distinct IPCL types were identified: normal, dilated, irregular, and chaotic, with increasing odds ratios for high-risk lesions. The ROC curve had an AUC of 0.913, with irregular and chaotic types providing the best diagnostic performance, achieving sensitivities and specificities of 84.2% and 88.4%, respectively. In the validation phase, the new classification achieved an overall diagnostic accuracy of 84.4% and substantial inter-observer consistency (κ = 0.694).Conclusion: The new IPCL classification effectively identifies high-risk oral lesions, enhancing the diagnostic utility of NBI for early detection of OPMDs malignant transformations.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome Analysis of HNSCC by Aggregatibacter actinomycetemcomitans Extracellular Vesicles. 放线菌胞外小泡对 HNSCC 的转录组分析

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-20 DOI: 10.1111/odi.15204

Jae Yeong Ha, Song-Yi Choi, Suk-Jeong Kim, Kristen Jin Seog, Su-Hyung Hong, Heon-Jin Lee

{"title":"Transcriptome Analysis of HNSCC by Aggregatibacter actinomycetemcomitans Extracellular Vesicles.","authors":"Jae Yeong Ha, Song-Yi Choi, Suk-Jeong Kim, Kristen Jin Seog, Su-Hyung Hong, Heon-Jin Lee","doi":"10.1111/odi.15204","DOIUrl":"https://doi.org/10.1111/odi.15204","url":null,"abstract":"Objectives: The role of extracellular vesicles (EVs), also known as outer membrane vesicles (OMVs), secreted by oral bacteria in the progression of head and neck squamous cell carcinomas (HNSCCs), is largely unexplored. This study aimed to investigate the influence of bacterial EVs, specifically those derived from Aggregatibacter actinomycetemcomitans (Aa), on the progression of HNSCC.Materials and methods: FaDu and UMSCC1 cell lines were treated with Aa-derived EVs, and oncogenic activities were assessed. Comprehensive cellular and RNA-sequencing transcriptome analyses were conducted to assess the impact of these EVs on cell cycle progression and gene expression.Results: Our findings reveal that Aa-derived EVs accelerate cell cycle progression through the S and G2 phases and enhance invasion in HNSCC cell lines. RNA-sequencing analysis showed that Aa-derived EVs exert a more significant effect on general transcript expression than on microRNA profiles, except for miR-146a, which is recognized as a key factor in both carcinogenesis and immune modulation.Conclusions: Bacterial EVs, particularly from periodontal pathogens like Aa, are significant modulators within the oral cancer environment, potentially affecting cellular behavior and gene expression profiles. This study highlights the complex relationship between periodontal health and oral carcinogenesis, emphasizing the significant role of bacterial EVs in HNSCC progression.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental and Craniofacial Anomalies in Fanconi Anemia: A Systematic Review and Additional 46 Reports. 范可尼贫血症的牙齿和颅面畸形：系统综述和其他 46 篇报告

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-20 DOI: 10.1111/odi.15205

Paula Alves da Silva Rocha, Nayara Conceição Marcos Santana, José Alcides Almeida de Arruda, Tania Mara Pimenta Amaral, Victor Zanetti Drumond, Cassius Carvalho Torres-Pereira, Ana Carolina Acevedo, Ariane Berdal, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Benjamin P J Fournier

{"title":"Dental and Craniofacial Anomalies in Fanconi Anemia: A Systematic Review and Additional 46 Reports.","authors":"Paula Alves da Silva Rocha, Nayara Conceição Marcos Santana, José Alcides Almeida de Arruda, Tania Mara Pimenta Amaral, Victor Zanetti Drumond, Cassius Carvalho Torres-Pereira, Ana Carolina Acevedo, Ariane Berdal, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Benjamin P J Fournier","doi":"10.1111/odi.15205","DOIUrl":"https://doi.org/10.1111/odi.15205","url":null,"abstract":"Objective: Fanconi anemia (FA), a rare genetic disorder, has not been comprehensively studied regarding its dental and craniofacial phenotypes. This study aimed to systematically review the available evidence on dental, occlusion, and craniofacial anomalies in individuals with FA and to describe the occurrence of these anomalies in a cohort from two Brazilian referral centers.Materials and methods: Electronic searches were conducted across six databases, supplemented by manual searches and gray literature. The Brazilian cohort included 46 patients diagnosed with FA.Results: A total of 19 articles describing 158 cases of FA were analyzed. The estimated prevalence of dental/craniofacial anomalies ranged from 13.3% to 71.4%. In our cohort, 93.5% of patients exhibited anomalies, primarily root abnormalities (69.6%), tooth rotation (54.3%), and tooth agenesis (26%). Males (p = 0.031) and individuals with endocrine disorders (p = 0.047) were more likely to experience alterations in eruption and/or exfoliation. Anomalies in size and shape were significantly more prevalent among individuals who had undergone hematopoietic stem-cell transplantation at age 14 or older (p = 0.002).Conclusion: The high occurrence of dental/craniofacial anomalies in individuals with FA suggests that these anomalies are part of the disease's phenotypic spectrum, emphasizing the need to expand and standardize the diagnostic criteria of the disease.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms Underlying Medication-Related Osteonecrosis of the Jaw. 与药物相关的颌骨坏死的机制

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-18 DOI: 10.1111/odi.15198

Kyeongho Lee, Kihun Kim, June Yeon Kim, Jin-Woo Kim, Young-Hoon Kang, Yun Hak Kim, Sung-Jin Kim

{"title":"Mechanisms Underlying Medication-Related Osteonecrosis of the Jaw.","authors":"Kyeongho Lee, Kihun Kim, June Yeon Kim, Jin-Woo Kim, Young-Hoon Kang, Yun Hak Kim, Sung-Jin Kim","doi":"10.1111/odi.15198","DOIUrl":"https://doi.org/10.1111/odi.15198","url":null,"abstract":"Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but debilitating disease characterized by a progressive necrosis of jaw bones in patients who have received anti-resorptive or anti-angiogenic therapies. Unfortunately, we still have no validated preventive or pharmaceutical interventions to help these patients, primarily due to our limited understanding of MRONJ pathogenesis. Here, we offer an extensive review of recent studies relevant to MRONJ pathogenesis. We present a hypothesis regarding the coupling of bone resorption and angiogenesis that relies on osteoblast-derived, matrix-bound vascular endothelial growth factors to explain why ONJ is associated with both anti-resorptive and anti-angiogenic agents.Methods: A narrative review was conducted by searching databases, including PubMed, Scopus, Google Scholar, and Web of Science, to retrieve relevant reports.Results: Reduced bone resorption leads to reduced angiogenesis, and vice versa, creating a vicious cycle that ultimately results in ischemic necrosis of the jaw. Additionally, we suggest that reduced angiogenesis, induced by anti-resorptive or anti-angiogenic agents, aggravates bacterial infection-induced bone necrosis, explaining why the jaw bone is particularly susceptible to necrosis.Conclusion: Our novel hypothesis will facilitate the advancement of future research and the development of more targeted approaches to managing MRONJ.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth. 活性基质金属蛋白酶-8、髓过氧化物酶与牙周病、早产的关系

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-14 DOI: 10.1111/odi.15202

Murat Alan, Timo Sorsa, Pınar Meriç Kantar, Ismo T Raisanen, Önder Gürlek, Burcu Kanmaz, Nurcan Buduneli

{"title":"Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth.","authors":"Murat Alan, Timo Sorsa, Pınar Meriç Kantar, Ismo T Raisanen, Önder Gürlek, Burcu Kanmaz, Nurcan Buduneli","doi":"10.1111/odi.15202","DOIUrl":"10.1111/odi.15202","url":null,"abstract":"Objective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters.Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries. aMMP-8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non-parametric tests.Results: PTBE group exhibited higher full-mouth probing depth and clinical attachment loss values than the other two groups (p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups (p < 0.05). Serum aMMP-8 and MPO concentrations were higher in PTPE group than in the other groups (p < 0.05). Placenta aMMP-8 level was higher in the control group than in the PTPE group (p < 0.05). There was no significant difference between the groups in the placenta MPO levels (p > 0.05).Conclusions: Within the limits of this cross-sectional study, it may be suggested that serum aMMP-8 and MPO concentrations together with placenta aMMP-8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Liver Clots" in Periodontology: A 10-Year Clinical Experience. 牙周病学中的 "肝血块"：10 年临床经验

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15190

Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Kumara Raja, Sukhbir Singh Chopra

{"title":"\"Liver Clots\" in Periodontology: A 10-Year Clinical Experience.","authors":"Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Kumara Raja, Sukhbir Singh Chopra","doi":"10.1111/odi.15190","DOIUrl":"10.1111/odi.15190","url":null,"abstract":"Objectives: \"Liver clots\" are an uncommon complication following periodontal surgery, characterized by their distinctive gelatinous consistency and color resembling 'liver' tissue. Despite anecdotal reports, there is a lack of comprehensive evidence in the literature regarding its incidence, etiopathogenesis and optimal management strategies. This study aimed to address this knowledge gap by retrospectively analyzing cases to provide insights into this unusual post-operative complication.Materials and methods: In this retrospective descriptive study, data spanning a decade (June 2013-June 2024) were collected from various dental centres. The data included patient demographics, medical history, surgical procedures performed, occurrence of \"liver clot\" formation, management measures and treatment outcomes.Results: The 10-year retrospective data revealed a 2.03% incidence of \"liver clots\" among various periodontal procedures. The highest occurrence was observed following dental extractions, followed by periodontal surgical procedures. The observations also indicated a higher frequency in systemically healthy individuals.Conclusion: \"Liver clot\" formation is a rare, but specific complication after periodontal surgery. Minimally invasive management approaches are effective, highlighting the importance of vigilance and prompt intervention for optimal patient outcomes. Further research is warranted to elucidate the exact etiopathogenesis and to establish evidence-based management protocols for this unusual complication.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply: "Hydroxychloroquine Is Effective in Oral Lichen Planus". 作者的回复："羟氯喹对口腔扁平苔藓有效》。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15178

Yulang Xie, Hao Xu, Yu Zhou, Qianming Chen

引用次数: 0

Advancing Research on Obesity and Salivary Microbiota: A Community Health Perspective. 推进肥胖与唾液微生物群的研究：社区健康视角。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15199

Yu Feng, Chang Liu, Yifan Hao, Hui Gu

引用次数: 0

ApoEVs Transfer Mitochondrial Component to Modulate Macrophages in Periodontal Regeneration. 载脂蛋白EV转移线粒体成分，调节牙周再生中的巨噬细胞。

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15181

Xiaodong Liu, Yun Lyu, Yejia Yu, Zhuo Wang, Yanping Sun, Maojiao Li, Chao Liang, Weidong Tian, Li Liao

{"title":"ApoEVs Transfer Mitochondrial Component to Modulate Macrophages in Periodontal Regeneration.","authors":"Xiaodong Liu, Yun Lyu, Yejia Yu, Zhuo Wang, Yanping Sun, Maojiao Li, Chao Liang, Weidong Tian, Li Liao","doi":"10.1111/odi.15181","DOIUrl":"https://doi.org/10.1111/odi.15181","url":null,"abstract":"Objective: Macrophages are key players in the host immune response to periodontal pathogens and tissue repair. The aim of this study was to explore the potential of apoptotic cell-derived extracellular vesicles (ApoEVs) in modulating the mitochondrial function of macrophages as a mean to enhance periodontal tissue regeneration.Subjects and methods: ApoEVs were extracted from periodontal ligament stem cells (PDLSCs) and characterized to observe their effects on macrophage function. In vivo experiments, ApoEVs were mixed with hyaluronic acid and injected into the periodontal pockets of rats with periodontitis to observe their impact on periodontal tissue regeneration and the immune microenvironment. Functional assays were conducted to confirm whether ApoEVs contained mitochondrial components and which specific components were transferred to regulate macrophage function.Results: The experimental findings showed that treatment of ApoEVs efficiently restored the homeostasis of macrophage and improved tissue regeneration in a periodontitis rat model. Mechanism investigation demonstrated that the efferocytosis of ApoEVs resulted in the transfer of mitochondrial components from PDLSCs to macrophage. The increased mitochondrial components within macrophages improved mitochondrial function and polarization of macrophages towards the anti-inflammatory M2 phenotype, resulting in the improvement of inflammatory environment in periodontal tissues.Conclusion: ApoEVs can transfer mtDNA to enhance mitochondrial function in macrophages, fostering their transition to an anti-inflammatory phenotype. Ultimately, this process improves the immune microenvironment in periodontitis and promotes periodontal tissue regeneration.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells. OLP 病变中的 HSP90 复合物通过激活树突状细胞诱导 T 细胞极化

IF 2.9 3区医学

Oral diseases Pub Date : 2024-11-12 DOI: 10.1111/odi.15195

Lei Pan, Junjun Chen, Yirao Lai, Guanhuan Du, Haiyan Wang, Lei Sun, Guoyao Tang, Yufeng Wang

{"title":"HSP90 Complex From OLP Lesion Induces T-Cell Polarization via Activation of Dendritic Cells.","authors":"Lei Pan, Junjun Chen, Yirao Lai, Guanhuan Du, Haiyan Wang, Lei Sun, Guoyao Tang, Yufeng Wang","doi":"10.1111/odi.15195","DOIUrl":"https://doi.org/10.1111/odi.15195","url":null,"abstract":"Objectives: To investigate the effects of the heat shock protein 90 (HSP90) complex from oral lichen planus (OLP) lesion tissues on dendritic cell (DC) activation and the polarization of naïve T cells.Methods: Expression of HSP90 in OLP lesions and healthy control (HC) mucosa was evaluated by single-cell RNA sequence, IHC, qRT-PCR, and immunoblotting. HSP90 complex was extracted by immunoprecipitation from oral mucosa as the agonist of DCs. Expression of IFN-α and MHC was detected by flow cytometry. After cocultured with pre-stimulated DCs, polarization of naïve T cells was investigated by cytokine analysis.Results: HSP90 was significantly higher in the lamina propria of OLP lesion and closely related to lymphocyte infiltration. HSP90 complex of OLP lesion activated DCs via TLR9 and increased their IFN-α secretion and MHC II expression. Pre-stimulated DCs increased the proportion of Th17 cells.Conclusions: HSP90 complex isolated from OLP lesion activated TLR9/IFN-α of DCs and further promoted the polarization of naïve T cells toward Th17 immunity.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0