Oral diseases最新文献_第7页

Comment on 'Osteoradionecrosis incidence in pre-radiation teeth extractions: A prospective study. 就 "辐射前拔牙的骨坏死发生率 "发表评论：前瞻性研究

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-09-03 DOI: 10.1111/odi.15113

Efsun Somay, Duriye Ozturk, Erkan Topkan

引用次数: 0

Effects of D₃K₂ With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients. D3K2 对糖尿病和 I-II 期牙周炎患者牙周治疗的影响

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-06 DOI: 10.1111/odi.15147

Tolga Aydogan, Meltem Karsiyaka Hendek, Berrin Unsal, Aydın Çifci, Hakan Varol, Uçler Kisa, Ebru Olgun

{"title":"Effects of D3K2 With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients.","authors":"Tolga Aydogan, Meltem Karsiyaka Hendek, Berrin Unsal, Aydın Çifci, Hakan Varol, Uçler Kisa, Ebru Olgun","doi":"10.1111/odi.15147","DOIUrl":"10.1111/odi.15147","url":null,"abstract":"Background: The aim of this study is to look into the clinical and biochemical outcomes of D3K2 supplementation in addition to nonsurgical periodontal treatment (NSPT) for patients suffering from diabetes mellitus (DM) and periodontitis.Methods: Thirty-eight participants with DM and periodontitis were randomized into two different groups. The test group provided NSPT with D3K2 whereas the control group received NSPT with placebo. Clinical periodontal parameters were recorded and serum and gingival crevicular fluid (GCF) were sampled at baseline and at the third and the sixth months after treatment. Glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 25(OH)D3, parathyroid hormone (PTH), calcium (Ca) and magnesium (Mg) values were determined in blood samples. GCF and serum interleukin (IL)-1β and IL-10 levels were analyzed using enzyme-linked immunosorbent assay.Results: All clinical periodontal parameters were importantly decreased at the third and sixth months after treatment compared to baseline in both groups. At the sixth month, 25(OH)D3 levels in the test group were observed to be statistically significantly higher than in the control group (p = 0.02). Serum IL-1β showed a statistically significant decrease at the sixth month compared to baseline and the third month in control group.Conclusion: According to this study, there is limited additional benefit of D3K2 given with NSPT in individuals with DM and periodontitis.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"640-647"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The risks of artificial intelligence: A narrative review and ethical reflection from an Oral Medicine group. 人工智能的风险：口腔医学小组的叙事回顾与伦理反思。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1111/odi.15100

Qingmei Joy Feng, Molly Harte, Barbara Carey, Ali Alqarni, Luis Monteiro, Márcio Diniz-Freitas, Jean-Cristophe Fricain, Giovanni Lodi, Vlaho Brailo, Mattia Andreoletti, Rui Albuquerque

{"title":"The risks of artificial intelligence: A narrative review and ethical reflection from an Oral Medicine group.","authors":"Qingmei Joy Feng, Molly Harte, Barbara Carey, Ali Alqarni, Luis Monteiro, Márcio Diniz-Freitas, Jean-Cristophe Fricain, Giovanni Lodi, Vlaho Brailo, Mattia Andreoletti, Rui Albuquerque","doi":"10.1111/odi.15100","DOIUrl":"10.1111/odi.15100","url":null,"abstract":"As a relatively new tool, the use of artificial intelligence (AI) in medicine and dentistry has the potential to significantly transform the healthcare sector. AI has already demonstrated efficacy in medical diagnosis across several specialties, used successfully to detect breast, lung and skin cancer. In Oral Medicine, AI may be applied in a similar fashion, used in the detection and diagnosis of oral cancers and oral potentially malignant diseases. Despite its promise as a transformative diagnostic aid, the use of AI in healthcare presents significant safety, reliability and ethical concerns. There is no formal consensus on the safe and ethical implementation of AI systems in healthcare settings, but the literature converges on several key principles of ethical AI use including transparency, justice and fairness, non-maleficence, responsibility and privacy. This article provides a narrative review of the key ethical issues surrounding AI use in medicine, and reflects on these, providing view-points of a bioethicist and Oral Medicine clinicians from several units.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"348-353"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrin aggravates periodontitis through inducing NETs formation from mitochondrial DNA. 纤维蛋白通过诱导线粒体 DNA 形成 NETs 使牙周炎恶化。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-07-26 DOI: 10.1111/odi.15073

Yinan Chen, Enhua Mei, Shunxue Nan, Xueting Chen, Pengye Zhang, Qingyu Zhu, Dongmei Lan, Shengcai Qi, Yan Wang

{"title":"Fibrin aggravates periodontitis through inducing NETs formation from mitochondrial DNA.","authors":"Yinan Chen, Enhua Mei, Shunxue Nan, Xueting Chen, Pengye Zhang, Qingyu Zhu, Dongmei Lan, Shengcai Qi, Yan Wang","doi":"10.1111/odi.15073","DOIUrl":"10.1111/odi.15073","url":null,"abstract":"Objectives: This study investigated the role of fibrin on neutrophil extracellular traps (NETs) formation from neutrophils and to elucidate the involvement of mitochondria in NETs formation during periodontitis.Materials and methods: Plasminogen-deficient (Plg-/-) mice were employed to evaluate the effects of fibrin deposition on inflammation, bone resorption, and neutrophil infiltration in periodontal tissues. In addition, in vitro tests evaluated fibrin's impact on neutrophil-driven inflammation. Mitochondrial reactive oxygen species (mtROS) levels within neutrophils were quantified utilizing flow cytometry and immunofluorescence in vitro. Furthermore, the anti-inflammatory properties of the mtROS scavenger, Mito-TEMPO, were confirmed to regulate the NET formation in vitro and in vivo.Results: Plasminogen deficiency resulted in increased fibrin deposition, neutrophil infiltration, inflammatory factors concentration, and alveolar bone resorption in periodontal tissues. After neutrophils were treated by fibrin in vitro, the expression of inflammatory factors, the formation of mtROS, and NETs enriched in mitochondrial DNA (mtDNA) were upregulated, which were reversed by Mito-TEMPO in vitro. Moreover, Mito-TEMPO alleviated inflammation in Plg-/- mice.Conclusions: This study showed that fibrin deposition in gingiva induced the NET formation in Plg-/- mice, in which the DNA in NETs was from mitochondria depending on increasing mtROS.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"577-588"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Accuracy of Toluidine Blue Electrospun in Detecting Oral Potentially Malignant Disorders. 甲苯胺蓝电纺丝检测口腔潜在恶性疾病的诊断准确性。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-22 DOI: 10.1111/odi.15161

Supanat Supakornpichan, Pratchaya Tipduangta, Surawut Pongsiriwet, Nutchapon Chamusri, Jitjiroj Ittichaicharoen, Nutchada Sriyaranya

{"title":"Diagnostic Accuracy of Toluidine Blue Electrospun in Detecting Oral Potentially Malignant Disorders.","authors":"Supanat Supakornpichan, Pratchaya Tipduangta, Surawut Pongsiriwet, Nutchapon Chamusri, Jitjiroj Ittichaicharoen, Nutchada Sriyaranya","doi":"10.1111/odi.15161","DOIUrl":"10.1111/odi.15161","url":null,"abstract":"Objective: Oral potentially malignant disorders (OPMDs) with epithelial dysplasia can progress to oral squamous cell carcinoma (OSCC). Toluidine blue (TB) has been used in oral screening with various methods. This study aimed to evaluate the sensitivity and specificity of TB-containing electrospun fibers in detecting OPMDs with epithelial dysplasia compared to histopathology.Methods: The concentrations of polyvinylpyrrolidone (PVP) and TB were optimized for fiber diameter and puncture strength using the design of experiments method with a central composite design. These optimized fibers were tested on 36 suspected OPMD lesions in 30 patients, followed by a biopsy for histopathological examination.Results: The quadratic and two-factor interaction models described the relationship between TB and PVP concentrations and fiber characteristics. The TB-containing electrospun fibers had 77.3% sensitivity and 35.7% specificity in detecting OPMDs with epithelial dysplasia.Conclusion: The TB-containing electrospun fibers offer advantages such as easy application, cost-effectiveness, and enhanced sensitivity in identifying OPMDs with epithelial dysplasia. However, their diagnostic accuracy is insufficient as a standalone diagnostic method, and they should be considered an adjunctive tool for detecting dysplastic changes in the oral epithelium.Trial registration: Thailand Clinical Trials Registry: TCTR20240429002.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"435-443"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenging ChatGPT-4V for the Diagnosis of Oral Diseases and Conditions. 挑战 ChatGPT-4V 诊断口腔疾病和病症。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-25 DOI: 10.1111/odi.15169

Márcio Diniz-Freitas, Lucía Lago-Méndez, Jacobo Limeres-Posse, Pedro Diz-Dios

引用次数: 0

Characteristics of sialolithiasis in Israel, a big-data retrospective study of 5100 cases. 以色列霰粒肿的特点，5100 例病例的大数据回顾性研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-08-04 DOI: 10.1111/odi.15095

Ehud Jonas, Daniel Muchnik, Idan Rabinovich, Daya Masri, Gavriel Chaushu, Gal Avishai

{"title":"Characteristics of sialolithiasis in Israel, a big-data retrospective study of 5100 cases.","authors":"Ehud Jonas, Daniel Muchnik, Idan Rabinovich, Daya Masri, Gavriel Chaushu, Gal Avishai","doi":"10.1111/odi.15095","DOIUrl":"10.1111/odi.15095","url":null,"abstract":"Objective: The aim of this study was to identify risk factors for sialolithiasis patients using a large community and hospital-based cohort.Methods: A retrospective case-control study was conducted on 20,396 individuals, including 5100 sialolithiasis patients and 15,296 matched controls. Demographics and laboratory data were obtained from electronic medical records. Statistical analyses were performed to identify significant differences between the two groups. A p-value of <0.05 was considered significant.Results: Sialolithiasis was more prevalent in women, with a mean age at diagnosis of 55.75 years. Several geographic location variables emerged as risk factors for sialolithiasis including Israeli birth, higher socioeconomic communities, and specific areas of residency. Tobacco smoking (odds ratio = 1.46) was a significant risk factor. Low high-density lipoprotein levels, elevated triglycerides, and elevated amylase levels were associated with sialolithiasis.Conclusions: This study provides valuable insights into the demographic and laboratory characteristics of sialolithiasis patients, indicating that area of residency and lifestyle factors contribute to the risk of developing sialolithiasis. The findings may contribute to a better understanding of the disease and the development of preventative measures or early diagnostics tools.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"503-509"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender inequalities in oral medicine and pathology research: Temporal trends of two decades. 口腔医学和病理学研究中的性别不平等：二十年的时间趋势。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-08-20 DOI: 10.1111/odi.15105

Gabriel Lima Braz, Amanda Dos Santos Figueiredo, Alini Cardoso Soares, Francielli Fernandez Garcia, Camila Barcellos Calderipe, Luiz Alexandre Chisini, Ana Carolina Uchoa Vasconcelos

{"title":"Gender inequalities in oral medicine and pathology research: Temporal trends of two decades.","authors":"Gabriel Lima Braz, Amanda Dos Santos Figueiredo, Alini Cardoso Soares, Francielli Fernandez Garcia, Camila Barcellos Calderipe, Luiz Alexandre Chisini, Ana Carolina Uchoa Vasconcelos","doi":"10.1111/odi.15105","DOIUrl":"10.1111/odi.15105","url":null,"abstract":"Objectives: To analyze gender inequities and trends in the authorship of articles published in high-impact factor journals of the field of Oral Medicine and Pathology.Methods: The gender and country of first and last authors were retrieved from original articles published between 2000 and 2022. Poisson regression models and classification and regression tree (CART) analysis were performed.Results: A total of 6595 studies were analyzed for first authorship, and 6627 for last authorship. Only 39.2% (CI 95% 38.0-40.3) of the first authors and 24.1% (CI 95% 23.1-25.1) of the last authors were females. Females consistently faced underrepresentation throughout the 23-year evaluation. The only region where female first authors are not a minority is Latin America. Having a female as the last author increased the prevalence of females in the first author position by 42% (PR = 1.42, CI 95% [1.30-1.54]). The most important discriminant variable by CART was the first author region.Conclusion: Although a slight decrease in underrepresentation was noted over the period, after 2020, the gender gap tended to widen for both first and last authors. It is crucial to implement measures aimed at attracting, retaining, and advancing women in the field of science, while also actively monitoring advancements toward achieving gender equity.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"682-689"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungiform Papillae and Gustatory Function in Neurofibromatosis Type 1: A Case-Control Study. 神经纤维瘤病 1 型的真菌乳头与味觉功能：一项病例对照研究。

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-14 DOI: 10.1111/odi.15148

Flavia Kleinsorgen, Eloá Borges Luna, Pâmella de Pinho Montovani, Analucia Rampazzo Xavier, Alexandra Anastacio Monteiro Silva, Rafaela Elvira Rozza-de-Menezes, Karin Soares Cunha

{"title":"Fungiform Papillae and Gustatory Function in Neurofibromatosis Type 1: A Case-Control Study.","authors":"Flavia Kleinsorgen, Eloá Borges Luna, Pâmella de Pinho Montovani, Analucia Rampazzo Xavier, Alexandra Anastacio Monteiro Silva, Rafaela Elvira Rozza-de-Menezes, Karin Soares Cunha","doi":"10.1111/odi.15148","DOIUrl":"10.1111/odi.15148","url":null,"abstract":"Objective: Fungiform papillae enlargement is a common oral manifestation of neurofibromatosis type 1 (NF1). This study aimed to objectively evaluate the size, number, and symmetry of fungiform papillae in NF1 individuals and investigate the relationship between these alterations and taste perception, salivary flow, dietary habits, and BMI.Materials and methods: A cross-sectional case-control study was conducted on 80 participants (40 with NF1 and 40 controls), matched by age and sex. Participants underwent quantitative and morphological evaluation of fungiform papillae, gustatory perception tests, sialometry, saliva analysis, xerostomia assessment, dietary assessments, and Body Mass Index calculations.Results: The NF1 group exhibited significantly larger and more asymmetric fungiform papillae and exhibited a higher detection threshold for sweet and sour tastes, as well as hyposalivation and lower preference for healthy foods compared to the controls. No correlation was found between papillae morphology, gustatory perception tests, saliva properties, xerostomia, food preferences, or BMI in the NF1 group.Conclusions: Enlarged and asymmetric fungiform papillae, hyposalivation, heightened sensitivity to sweet and sour tastes, and reduced healthy eating habits were common in NF1. Although fungiform papillae alterations seem unrelated to taste sensitivity and food preferences, further investigation is needed to better understand the mechanisms underlying these changes.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"656-671"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-10-28 DOI: 10.1111/odi.15165

Kentaro Urata, Tatsuki Oto, Yoshinori Hayashi, Suzuro Hitomi, Takayuki Ikeda, Koichi Iwata, Toshimitsu Iinuma, Masamichi Shinoda

{"title":"Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain.","authors":"Kentaro Urata, Tatsuki Oto, Yoshinori Hayashi, Suzuro Hitomi, Takayuki Ikeda, Koichi Iwata, Toshimitsu Iinuma, Masamichi Shinoda","doi":"10.1111/odi.15165","DOIUrl":"10.1111/odi.15165","url":null,"abstract":"Objective: Although macrophage polarisation in the trigeminal ganglion (TG) is crucial in orofacial pain hypersensitivity, the effect of ageing-related changes and their involvement in intra-oral nociception remains unclear. We assessed the effect of ageing-related macrophage polarisation in TG on intra-oral mechanical pain hypersensitivity following palatal mucosal incision using senescence-accelerated mice (SAM)-prone8 (SAMP8) and SAM-resistant 1 (SAMR1).Materials and methods: Mechanical head-withdrawal reflex threshold (MHWRT) of the palatal mucosa was measured for 21 days after palatal mucosal incision. On days 3 and 14, the abundance of Iba-1-immunoreactive (IR) cells, CD11c-IR cells (pro-inflammatory macrophages (M1)), C-C motif chemokine ligand 2 (CCL2)-IR M1-macrophages, CD206-IR cells (anti-inflammatory macrophages (M2)) and transforming growth factor-β (TGF-β)-IR M2-macrophages in the TG was analysed. The effect of continuous intra-TG administration of CCL2-neutralising antibody or recombinant-CCL2 on MHWRT was examined.Results: Incision-induced decrease in MHWRT was enhanced in SAMP8 compared with that in SAMR1. On days 3 and 14, the number of CCL2-IR M1-macrophages in TG was increased in SAMP8 compared with that in SAMR1. CCL2-neutralising antibody suppressed, whereas recombinant-CCL2 increased pain hypersensitivity in SAMP8.Conclusions: Mechanical pain hypersensitivity after oral mucosal injury is potentiated and sustained by age-related enhancement of CCL2 signalling via M1-macrophage hyperactivation in TG.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":"600-610"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0