{"title":"创伤性三叉神经病变的血清生物标志物及其临床相关性：一项初步研究。","authors":"Hye-Kyoung Kim, Insoon Chang, Sung-Hoon Lee","doi":"10.1111/odi.15322","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the serum biomarker levels in patients with painful post-traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients.</p><p><strong>Materials and methods: </strong>A total of 32 patients with PPTTN were included. Serum levels of various cytokines and neurotrophic factors were measured. Patients were assessed for clinical and psychological characteristics, including pain severity, pain interference, numbness severity, and symptom duration as well as psychological factors using validated questionnaires.</p><p><strong>Results: </strong>No significant differences in serum biomarker levels were found based on age, sex, pain severity, pain interference, or type of injured nerve after adjusting multiple comparisons. Significant differences were observed in interleukin-8 (IL-8) and brain-derived neurotrophic factor (BDNF) levels based on symptom duration, with higher levels in patients whose symptoms lasted for more than 6 months. Spearman correlation analysis revealed strong relationships between clinical and psychological variables. Pain outcomes were more strongly associated with psychological factors than with serum biomarkers.</p><p><strong>Conclusion: </strong>IL-8 and BDNF may be biomarkers for disease progression in PPTTN based on symptom duration, with pain outcomes more related to psychological factors rather than serum biomarker levels, highlighting the need for psychological support in management.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study.\",\"authors\":\"Hye-Kyoung Kim, Insoon Chang, Sung-Hoon Lee\",\"doi\":\"10.1111/odi.15322\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to investigate the serum biomarker levels in patients with painful post-traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients.</p><p><strong>Materials and methods: </strong>A total of 32 patients with PPTTN were included. Serum levels of various cytokines and neurotrophic factors were measured. Patients were assessed for clinical and psychological characteristics, including pain severity, pain interference, numbness severity, and symptom duration as well as psychological factors using validated questionnaires.</p><p><strong>Results: </strong>No significant differences in serum biomarker levels were found based on age, sex, pain severity, pain interference, or type of injured nerve after adjusting multiple comparisons. Significant differences were observed in interleukin-8 (IL-8) and brain-derived neurotrophic factor (BDNF) levels based on symptom duration, with higher levels in patients whose symptoms lasted for more than 6 months. Spearman correlation analysis revealed strong relationships between clinical and psychological variables. Pain outcomes were more strongly associated with psychological factors than with serum biomarkers.</p><p><strong>Conclusion: </strong>IL-8 and BDNF may be biomarkers for disease progression in PPTTN based on symptom duration, with pain outcomes more related to psychological factors rather than serum biomarker levels, highlighting the need for psychological support in management.</p>\",\"PeriodicalId\":19615,\"journal\":{\"name\":\"Oral diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/odi.15322\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.15322","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study.
Objectives: This study aims to investigate the serum biomarker levels in patients with painful post-traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients.
Materials and methods: A total of 32 patients with PPTTN were included. Serum levels of various cytokines and neurotrophic factors were measured. Patients were assessed for clinical and psychological characteristics, including pain severity, pain interference, numbness severity, and symptom duration as well as psychological factors using validated questionnaires.
Results: No significant differences in serum biomarker levels were found based on age, sex, pain severity, pain interference, or type of injured nerve after adjusting multiple comparisons. Significant differences were observed in interleukin-8 (IL-8) and brain-derived neurotrophic factor (BDNF) levels based on symptom duration, with higher levels in patients whose symptoms lasted for more than 6 months. Spearman correlation analysis revealed strong relationships between clinical and psychological variables. Pain outcomes were more strongly associated with psychological factors than with serum biomarkers.
Conclusion: IL-8 and BDNF may be biomarkers for disease progression in PPTTN based on symptom duration, with pain outcomes more related to psychological factors rather than serum biomarker levels, highlighting the need for psychological support in management.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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