Cardiovascular Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-31 DOI:10.1111/odi.70084

Vandana Gupta, Anika Dawar, Sumit Kumar Das, Vikender Singh Yadav, Vanshita Nalwa, Razia Haidrus, Bharathi M Purohit, Lata Goyal

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引用次数: 0

Abstract

Aim: This review aimed to synthesize evidence on cardiovascular biomarkers associated with periodontitis, identified in biofluids such as blood, saliva, and gingival crevicular fluid (GCF).

Methods: A comprehensive search of five databases was conducted to identify studies comparing cardiovascular biomarker levels in periodontitis and healthy individuals, up to 31 December 2024. Meta-analysis included biomarkers from ≥ 2 studies per biofluid, with sensitivity analysis performed and evidence certainty assessed using the GRADE tool.

Results: Thirty-six studies were included in the systematic review, with 31 eligible for meta-analysis. Overall, 39 biomarkers were identified: 33 in blood, 14 in saliva, and 6 in GCF. A meta-analysis was conducted for 12 blood biomarkers, of which high-density lipoprotein (HDL) was significantly reduced, low-density lipoprotein (LDL) was higher in periodontitis (though LDL lost significance on sensitivity analysis), and the oxidative stress index (OSI) was significantly associated with periodontitis. No significant differences were observed for C-reactive protein (CRP), interleukin-1beta (IL-1ß), interleukin (IL)-6, N-terminal pro-B-type natriuretic peptide (NT-proBNP), monocyte chemoattractant protein-1 (MCP-1), and asymmetric dimethylarginine (ADMA). CRP was the only biomarker pooled for saliva and GCF, with no significant findings.

Conclusion: Reduced blood HDL and elevated OSI represent potential cardiovascular biomarkers for periodontitis, although the certainty of evidence remains low.

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牙周炎的心血管生物标志物：一项系统综述和荟萃分析。

目的：本综述旨在综合血液、唾液和龈沟液（GCF）等生物流体中与牙周炎相关的心血管生物标志物的证据。方法：对五个数据库进行全面检索，以确定截至2024年12月31日牙周炎患者和健康个体心血管生物标志物水平的比较研究。荟萃分析包括来自每个生物流体≥2项研究的生物标志物，并进行敏感性分析和使用GRADE工具评估证据确定性。结果：系统评价纳入了36项研究，其中31项符合meta分析。总共鉴定了39种生物标志物：血液中33种，唾液中14种，GCF中6种。对12项血液生物标志物进行荟萃分析，其中高密度脂蛋白（HDL）显著降低，低密度脂蛋白（LDL）在牙周炎中升高（尽管LDL在敏感性分析中失去了显著性），氧化应激指数（OSI）与牙周炎显著相关。c反应蛋白（CRP）、白细胞介素-1 β （IL-1ß）、白细胞介素-6 （IL -6）、n端前b型利钠肽（NT-proBNP）、单核细胞趋化蛋白-1 （MCP-1）和不对称二甲基精氨酸（ADMA）无显著差异。CRP是唾液和GCF的唯一生物标志物，没有明显的发现。结论：血液HDL降低和OSI升高是牙周炎的潜在心血管生物标志物，尽管证据的确定性仍然很低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.