Siwei Xu, Kaixin Yan, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu
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Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits.
Background: The treatment procedure for intracapsular condylar fractures (ICF) is still being debated. The temporomandibular joint (TMJ) disc is a key factor for treating ICF. The study aims to investigate the changes in TMJ disc status and condylar cartilage regeneration following ICF in a rabbit model, to assist in planning treatment.
Methods: Adolescent and adult rabbits received surgery on the left TMJs: (1) ICF with anterior disc displacement, (2) ICF with the removal of the ICF segment and disc. The animals were euthanized immediately, and at 4, 8, and 12 weeks after surgery. Their left TMJs were collected for histological, SOX 9 immunohistochemical, and micro-CT analyses.
Results: All 36 TMJs (100%) showed anterior disc displacement at 4, 8, and 12 weeks after surgery. Also, condylar cartilage regeneration was observed in all 36 joints. Notably, partial regeneration of condylar cartilage was noted at 4 weeks after removal of the disc and ICF fractured segment in both adolescent and adult groups.
Conclusion: Anterior displaced disc after ICF in adolescent and adult rabbits exhibited sustained disc displacement without therapeutic intervention. TMJ disc and associated attachment are crucial in the condylar cartilage regeneration after ICF.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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