Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-01-02 DOI:10.1111/odi.15234

Liu-Yang Qu, Dan-Ni Zheng, Xiao-Tong Ling, Guan-Qi Liu, Xiao-Yun Xu, Deng-Gao Liu

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引用次数: 0

Abstract

Objective: To investigate the microarchitecture and crystalline composition of sialoliths and to explore their formation mechanisms.

Methods: Sixty-six sialolith samples (51 from the submandibular glands and 15 from the parotid glands) were retrospectively collected. Their diameter and quality were measured. Micro-computed tomography, scanning electron microscopy, and polycrystalline X-ray diffractometer (XRD) were utilized to determine their microstructure and crystalline composition.

Results: Stone diameter and weight averaged at 9.6 mm and 0.31 g, respectively. Submandibular stones showed larger size and weight than parotid stones. Microstructurally, the main stones were concentric (n = 51) or mixed (n = 15). Most concentric stones occurred at submandibular glands, while 80% of the mixed stones were parotid stones. Stone surface exhibited three microscopic structures: lamellar, grape-like, and porous, indicating their differences in mineralization process and composition. XRD revealed that all stones contained hydroxyapatite, with 57 containing whitlockite. Concentration of hydroxyapatite in concentric stones was significantly higher than that in mixed stones (p = 0.036) and correlated positively with stone diameter (p = 0.001). The microstructure and crystalline composition of multiple and recurrent stones were similar to that of single stones.

Conclusion: Sialoliths display pronounced diversity in microarchitecture and crystalline composition, reflecting the differences in mineralization process and local microenvironments among stones.

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目的：研究牙石的微观结构和结晶成分，并探索其形成机制：研究霰粒肿的微观结构和结晶成分，并探索其形成机制：回顾性收集 66 块霰粒岩样本（51 块来自颌下腺，15 块来自腮腺）。测量了它们的直径和质量。利用微型计算机断层扫描、扫描电子显微镜和多晶 X 射线衍射仪（XRD）确定了它们的微观结构和晶体成分：结石的直径和重量平均分别为 9.6 毫米和 0.31 克。颌下腺结石的尺寸和重量均大于腮腺结石。从显微结构上看，主要结石为同心结石（n = 51）或混合结石（n = 15）。大多数同心结石发生在颌下腺，而80%的混合结石为腮腺结石。结石表面呈现出三种微观结构：片状、葡萄状和多孔状，表明它们在矿化过程和成分上存在差异。X射线衍射显示，所有结石都含有羟基磷灰石，其中57颗含有白锁石。同心石中羟基磷灰石的浓度明显高于混合石（p = 0.036），并与石的直径呈正相关（p = 0.001）。多发性和复发性结石的微观结构和结晶成分与单个结石相似：结论：霰粒石的微观结构和结晶成分具有明显的多样性，反映了不同结石矿化过程和局部微环境的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.