Ophthalmologica最新文献_第2页

Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy. 脉冲类固醇治疗后 Vogt-Koyanagi-Harada 病患者眼部生物标志物的早期变化

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-11-21 DOI: 10.1159/000542724

Tetsuya Muto, Shunsuke Kawaguchi, Shoichiro Kusuda, Keita Misu, Masaaki Sakamoto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu

{"title":"Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy.","authors":"Tetsuya Muto, Shunsuke Kawaguchi, Shoichiro Kusuda, Keita Misu, Masaaki Sakamoto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu","doi":"10.1159/000542724","DOIUrl":"10.1159/000542724","url":null,"abstract":"Introduction: This study aimed to identify when ocular biomarker changes occur within 1 month and which ocular biomarkers correlate with best-corrected visual acuity (BCVA) at months 1 and 6.Methods: We evaluated 33 patients with Vogt-Koyanagi-Harada disease who received pulse steroid therapy. The central anterior-chamber depth (ACD) and peripheral ACD were evaluated. We also analyzed axial length (AL), BCVA, spherical equivalent (SE), choroidal foveal thickness (CFT), and retinal foveal thickness (RFT). Patients were divided into two groups based on BCVA at months 1 and 6, and correlations with ocular biomarkers were investigated.Results: RFT and CFT were significantly reduced as early as day 1 (p < 0.001). AL gradually increased, with a significant increase observed at month 1 (p < 0.05). BCVA improved significantly along with SE reduction, with significant changes observed at week 1 (p < 0.05 and p < 0.01, respectively). Anterior-chamber biomarkers gradually increased, with significant increases at week 2 for central ACD (p < 0.05) and at month 1 for peripheral ACD (p < 0.05). The better BCVA group at month 1 significantly correlated with thicker RFT (p < 0.01), better BCVA (p < 0.05), shallower central ACD (p < 0.05), and shallower peripheral ACD (p < 0.05) at the initial visit. No correlation was observed between the better BCVA group at month 6 and ocular biomarkers at the initial visit.Conclusion: Although RFT and CFT changes are the earliest indicators, changes in the anterior-chamber structure appeared to be slow and delayed. Thicker RFT, better BCVA, shallower central ACD, and shallower peripheral ACD at the initial visit correlated with better BCVA at 1 month.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dealing with the Verteporfin Shortage: Treatment Options and Outcomes in Patients with Chronic and Non-Resolving Central Serous Chorioretinopathy. 应对维替泊芬短缺：慢性和非缓解性中央浆液性脉络膜视网膜病变患者的治疗方案和疗效。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-10-24 DOI: 10.1159/000542224

Femke M van den Tillaart, Franca Hartgers, Carel B Hoyng, Suzanne Yzer

{"title":"Dealing with the Verteporfin Shortage: Treatment Options and Outcomes in Patients with Chronic and Non-Resolving Central Serous Chorioretinopathy.","authors":"Femke M van den Tillaart, Franca Hartgers, Carel B Hoyng, Suzanne Yzer","doi":"10.1159/000542224","DOIUrl":"10.1159/000542224","url":null,"abstract":"Introduction: Half-dose photodynamic therapy (HD-PDT) with verteporfin is the mainstay treatment in central serous chorioretinopathy (CSC). Since 2021, there is a worldwide shortage of verteporfin. This called for adjustments of daily practice. Here, we provide a comprehensive evaluation of the adapted treatment methods and outcomes in patients with non-resolving and chronic CSC.Methods: In this retrospective cohort study, we compared patients referred in the year before the verteporfin shortage (group 1), with patients referred in the first year of verteporfin shortage (group 2). Treatment strategies, subretinal fluid (SRF) resolution, and visual acuity (VA) were evaluated during a follow-up period of at least 4 months.Results: Eighty-five eyes of 79 patients were analyzed, 36 eyes in group 1 and 49 in group 2. The treatment strategy at the first visit shifted from HD-PDT as the most performed treatment in group 1 to a more patient-tailored approach in group 2, with a wait-and-see policy in most cases. During follow-up, HD-PDT was performed significantly less in group 2 (89% vs. 45%; p < 0.001). At a mean follow-up time of 6.2 months, SRF resolved in 61% of the eyes in group 1 and in 55% in group 2 (p = 0.821). No difference in VA was observed between the groups at follow-up (p = 0.637).Conclusion: During the shortage of verteporfin, a different treatment strategy was applied, with HD-PDT being performed less frequently. By implementing a more patient-tailored approach, the VA and the resolution rate of SRF remained similar to the year before the shortage.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of Optical Coherence Tomography Biomarkers after Peeling of Epiretinal Membranes. 剥离视网膜外膜后光学相干断层扫描生物标记物的变化

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-09-24 DOI: 10.1159/000541425

Christoph Leisser, Andreas Schlatter, Manuel Ruiss, Caroline Pilwachs, Oliver Findl

{"title":"Changes of Optical Coherence Tomography Biomarkers after Peeling of Epiretinal Membranes.","authors":"Christoph Leisser, Andreas Schlatter, Manuel Ruiss, Caroline Pilwachs, Oliver Findl","doi":"10.1159/000541425","DOIUrl":"10.1159/000541425","url":null,"abstract":"Introduction: Several optical coherence tomography (OCT) biomarkers for postsurgical success among patients with idiopathic epiretinal membranes (iERMs) undergoing pars plana vitrectomy and membrane peeling have been described in the past. The aim of this study was to examine the remission of OCT biomarkers in patients with iERM after pars plana vitrectomy with membrane peeling 3 months and 1 year after surgery.Methods: This prospective study included patients scheduled for pars plana vitrectomy with membrane peeling for iERM. The postoperative remission of presurgical OCT biomarkers was analyzed from OCTs at predefined time points (3 months, 1 year) after surgery and correlated with visual acuity.Results: Among 75 patients included, remission of pre-surgically present OCT biomarkers was observed in 87.5% of eyes with disorganization of retinal inner layers, in 82.4% with cotton ball sign, in 70.4% with intraretinal cystoid changes, in 57.1% with hyperreflective foci, in 51.2% with ectopic inner foveal layer (EIFL), and in all eyes with defects of the ellipsoid zone. Central macular thickness (CMT) showed a significant reduction after surgery (p < 0.001 and p = 0.019) and was the only significant predictor for development of distance-corrected visual acuity (DCVA) 1 year after surgery (p < 0.001).Conclusion: CMT was the only significant predictor for development of DCVA 1 year after surgery. Remission rates of most of the other OCT biomarkers were high, but did not significantly influence postsurgical DCVA.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Risk Factors for Metamorphopsia after Successful Retinal Detachment Surgery. 视网膜脱离手术成功后出现变形的发生率和风险因素。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-06-12 DOI: 10.1159/000539430

Geoffrey Pastor, Julia Salleron, Astrid Zessler, Sarah Stoebener, Karine Angioi-Duprez, Jean-Paul Berrod, Jean-Baptiste Conart

{"title":"Prevalence and Risk Factors for Metamorphopsia after Successful Retinal Detachment Surgery.","authors":"Geoffrey Pastor, Julia Salleron, Astrid Zessler, Sarah Stoebener, Karine Angioi-Duprez, Jean-Paul Berrod, Jean-Baptiste Conart","doi":"10.1159/000539430","DOIUrl":"10.1159/000539430","url":null,"abstract":"Introduction: The aim of the study was to determine the prevalence of metamorphopsia following rhegmatogenous retinal detachment (RRD) surgery, as well as associated predictive factors.Methods: A total of 107 eyes successfully operated for RRD underwent metamorphopsia severity assessment using M-CHARTS, and foveal microstructure analysis by spectral domain optical coherence tomography, at 1 and 6 months postoperatively. Univariate and multivariate logistic regression rendered evaluation of preoperative risk factors. The correlation between metamorphopsia score and outer retinal layer (ORL) integrity was investigated and preoperative risk factors evaluated.Results: The prevalence of postoperative metamorphopsia decreased from 51.4 to 29.9% and the median metamorphopsia score significantly improved (0.5, 95% CI: 0.3; 0.9, to 0.2, 95% CI: 0; 0.5, p < 0.001) from 1 to 6 months, respectively. Preoperative macular detachment was the only predictor found (OR 11.0, 95% CI: 3.1; 39.4, p < 0.001). Metamorphopsia severity was significantly associated with outer nuclear layer thickness and the status of the ellipsoid and cone interdigitation zones. One-month M-CHARTS had 81% sensitivity and 87% specificity in predicting full metamorphopsia recovery at 6 months (0.45 cut-off score).Conclusion: The prevalence of metamorphopsia decreased in parallel to ORL restoration, thus demonstrating the etiological role of photoreceptor-level morphological changes. M-CHARTS allowed for monitoring and predicting metamorphopsia recovery after RRD.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on Noninfectious Retinal Vasculitis. 非感染性视网膜血管炎的最新进展。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-06-05 DOI: 10.1159/000539608

Nitin Kumar Menia, Yasmine Alcibahy, Francesco Pichi, Piergiorgio Neri, Aniruddha Agarwal

{"title":"An Update on Noninfectious Retinal Vasculitis.","authors":"Nitin Kumar Menia, Yasmine Alcibahy, Francesco Pichi, Piergiorgio Neri, Aniruddha Agarwal","doi":"10.1159/000539608","DOIUrl":"10.1159/000539608","url":null,"abstract":"Background: Retinal vasculitis (RV) signifies the inflammation of various retinal vessels. Noninfectious RV differs from infectious RV with regard to its pathogenesis and treatment. It can have varied clinical presentations and may be associated with systemic vasculitic diseases.Summary: Noninfectious RV can be caused due to type-III hypersensitivity reactions, increased expression of intracellular adhesion molecules, and genetic susceptibility. Noninfectious RV is primarily classified on the basis of the type of retinal vessels involved. It can be further classified as an occlusive or nonocclusive. RV can be a major association of systemic diseases like Behcet's disease, sarcoidosis and systemic lupus erythematosus. Newer modalities, like ultra-widefield fundus fluorescein angiography, can help in the management of RV. Effective treatment of noninfectious RV requires anti-inflammatory and immunosuppressive therapy. The patients may require treatment with high-dose corticosteroids and biological agents. Anti-vascular endothelial growth factor injections and laser photocoagulation may be indicated to treat the occlusive disease. Prompt treatment may prevent complications like vitreous hemorrhage, neovascular glaucoma, and tractional retinal detachment. The treatment more often requires a multidisciplinary approach.Key messages: This review provides a comprehensive update on the various causes of noninfectious RV, including both systemic and isolated ocular conditions. It also details various complications and management strategies for this condition.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epiretinal Membrane Formation following Rhegmatogenous Retinal Detachment Repair: A Retrospective Cohort Study. 流变性视网膜脱离修复术后形成的视网膜外膜：回顾性队列研究

IF 2.6 4区医学

Ophthalmologica Pub Date : 2024-05-09 DOI: 10.1159/000537814

Marko M Popovic, Jenna M Berinstein, Jovany Franco, Henry W Zhou, Sohat Sharma, Frances Wu, Rajeev Muni, Leo Kim

{"title":"Epiretinal Membrane Formation following Rhegmatogenous Retinal Detachment Repair: A Retrospective Cohort Study.","authors":"Marko M Popovic, Jenna M Berinstein, Jovany Franco, Henry W Zhou, Sohat Sharma, Frances Wu, Rajeev Muni, Leo Kim","doi":"10.1159/000537814","DOIUrl":"10.1159/000537814","url":null,"abstract":"Introduction: This study aimed to investigate the incidence of and risk factors for epiretinal membrane (ERM) formation following primary rhegmatogenous retinal detachment (RRD) repair.Methods: This comparative, retrospective, single-center cohort study included eyes with primary RRD treated between 2011 and 2023 at Massachusetts Eye and Ear, Boston, Massachusetts, with pars plana vitrectomy (PPV), scleral buckle (SB), PPV+SB, or pneumatic retinopexy (PnR). Demographic, clinical, and surgical parameters were collected from medical records. The primary outcome was the risk of ERM formation, while the secondary outcome was the risk of ERM requiring surgery. Univariable and multivariable Cox regression were performed, and a hazard ratio (HR) and 95% confidence interval (95% CI) were reported.Results: Overall, 394 eyes were included. The mean age was 58.49 ± 12.8 years, and most patients were male. There was a significantly lower risk of ERM formation following SB compared to PPV in the univariable analysis (HR = 0.2, 95% CI = 0.08-0.60, p = 0.003); however, there was no significant association between treatment modality and ERM formation on multivariable Cox regression controlling for confounding factors (p = 0.24). ERM formation was found more commonly in patients who were older (HR = 1.0 per 1 year increase in age, 95% CI = 1.01-1.04, p = 0.001), those with worse baseline visual acuity (HR = 1.3, 95% CI = 1.09-1.71, p = 0.008), and those with macula-off RRDs (HR = 2.1, 95% CI = 1.41-3.32, p < 0.001).Conclusion: Surgical modality does not have a significant impact on the risk of ERM following retinal detachment repair. However, age, baseline visual acuity, and macular status are important predictors of ERM formation after RRD repair.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Autofluorescence at AMD's Beginnings Highlights Retinal Topography and Grading System Differences: ALSTAR2 Baseline. AMD 初期的定量自发荧光可突出显示视网膜地形图和分级系统的差异：ALSTAR2 基线。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-04-24 DOI: 10.1159/000538696

Andreas Berlin, Nathan A Fischer, Mark E Clark, Deepayan Kar, Thomas A Swain, Richard M Martindale, Gerald McGwin, Jason N Crosson, Kenneth R Sloan, Cynthia Owsley, Christine A Curcio

{"title":"Quantitative Autofluorescence at AMD's Beginnings Highlights Retinal Topography and Grading System Differences: ALSTAR2 Baseline.","authors":"Andreas Berlin, Nathan A Fischer, Mark E Clark, Deepayan Kar, Thomas A Swain, Richard M Martindale, Gerald McGwin, Jason N Crosson, Kenneth R Sloan, Cynthia Owsley, Christine A Curcio","doi":"10.1159/000538696","DOIUrl":"10.1159/000538696","url":null,"abstract":"Introduction: The aims of the study were to describe baseline quantitative (short-wavelength) autofluorescence (qAF) findings in a large pseudophakic cohort at age-related macular degeneration (AMD)'s beginnings and to assess qAF8 as an outcome measure and evaluate Age-Related Eye Disease Study (AREDS) and Beckman grading systems.Methods: In the ALSTAR2 baseline cohort (NCT04112667), 346 pseudophakic eyes of 188 persons (74.0 ± 5.5 years) were classified as normal (N = 160 by AREDS, 158 by Beckman), early AMD (eAMD) (N = 104, 66), and intermediate AMD (iAMD) (N = 82, 122). Groups were compared via mean qAF intensities in a 6°-8° annulus (qAF8) and maps of differences between observations and the overall mean, divided by standard deviation (Z-score).Results: qAF8 did not differ significantly among diagnostic groups by either stratification (p = 0.0869 AREDS; p = 0.0569 by Beckman). Notably, 45 eyes considered eAMD by AREDS became iAMD by Beckman. For AREDS-stratified eyes, Z-score maps showed higher centrally located qAF for normal, near the mean in eAMD, and lower values for iAMD. Maps deviated from this pattern for Beckman-stratified eyes.Conclusions: In a large sample of pseudophakic eyes, qAF8 does not differ overall from normal aging to iAMD but also does not capture the earliest AMD activity in the macula lutea. AREDS classification gives results more consistent with a slow decline in histologic autofluorescence than Beckman classification.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11499297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of chronic central serous chorioretinopathy through combined manual annotation and AI-assisted volume measurement of flat irregular pigment epithelium. 通过人工标注和人工智能辅助测量扁平不规则色素上皮的体积，预测慢性中心性浆液性脉络膜视网膜病变。

IF 2.6 4区医学

Ophthalmologica Pub Date : 2024-03-29 DOI: 10.1159/000538543

Lorenzo Ferro Desideri, Davide Scandella, Lieselotte Berger, Raphael Sznitman, Martin Zinkernagel, Rodrigo Anguita

{"title":"Prediction of chronic central serous chorioretinopathy through combined manual annotation and AI-assisted volume measurement of flat irregular pigment epithelium.","authors":"Lorenzo Ferro Desideri, Davide Scandella, Lieselotte Berger, Raphael Sznitman, Martin Zinkernagel, Rodrigo Anguita","doi":"10.1159/000538543","DOIUrl":"https://doi.org/10.1159/000538543","url":null,"abstract":"Introduction: The aim of this study is to investigate the role of an artificial intelligence (AI)-developed OCT program to predict the clinical course of central serous chorioretinopathy (CSC ) based on baseline pigment epithelium detachment (PED) features.Methods: Single-center, observational study with a retrospective design. Treatment-naïve patients with acute CSC and chronic CSC were recruited and OCTs were analyzed by an AI-developed platform (Discovery OCT Fluid and Biomarker Detector, RetinAI AG, Switzerland), providing automatic detection and volumetric quantification of PEDs. Flat irregular PED presence was annotated manually and afterwards measured by the AI program automatically.Results: 115 eyes of 101 patients with CSC were included, of which 70 were diagnosed with chronic CSC and 45 with acute CSC. It was found that patients with baseline presence of foveal flat PEDs and multiple flat foveal and extrafoveal PEDs had a higher chance of developing chronic form. AI-based volumetric analysis revealed no significant differences between the groups.Conclusions: While more evidence is needed to confirm the effectiveness of AI-based PED quantitative analysis, this study highlights the significance of identifying flat irregular PEDs at the earliest stage possible in patients with CSC, to optimize patient management and long-term visual outcomes.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Submacular hemorrhage during neovascular age-related macular degeneration: a meta-analysis and meta-regression on the use of tPA and anti-VEGFs. 新生血管性老年黄斑变性期间的黄斑下出血：关于使用 tPA 和抗血管内皮生长因子的荟萃分析和荟萃回归。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-03-29 DOI: 10.1159/000537939

Daniele Veritti, Valentina Sarao, Deborah Martinuzzi, Sara Menzio, Paolo Lanzetta

{"title":"Submacular hemorrhage during neovascular age-related macular degeneration: a meta-analysis and meta-regression on the use of tPA and anti-VEGFs.","authors":"Daniele Veritti, Valentina Sarao, Deborah Martinuzzi, Sara Menzio, Paolo Lanzetta","doi":"10.1159/000537939","DOIUrl":"10.1159/000537939","url":null,"abstract":"Background: Submacular hemorrhage (SMH) associated with neovascular age-related macular degeneration (nAMD) precipitates rapid visual decline and impacts quality of life. Treatments vary, but combined recombinant tissue plasminogen activator (tPA) and anti-vascular endothelial growth factor (anti-VEGF) therapy has gained prominence as a viable treatment option.Objectives: This study aims to evaluate the efficacy of the combination of tPA and anti-VEGF.Methods: We conducted a systematic review meta-analysis following PRISMA guidelines, focusing on studies examining tPA and anti-VEGF therapy in SMH secondary to nAMD. Outcomes measured were change in best-corrected visual acuity (BCVA) and success rate of SMH displacement. Meta-regression assessed the relative efficacy of intravitreal and subretinal delivery.Results: Out of 257 initial reports, 22 studies involving 29 patient populations met inclusion criteria. Our analysis showed significant improvement in BCVA and a high rate of successful SMH displacement with combined tPA and anti-VEGF therapy. No significant differences were found between subretinal and intravitreal tPA administration. Furthermore, when evaluating the effects of subretinal versus intravitreal anti-VEGF administration in patients treated with subretinal tPA, the results indicated similar efficacy.Conclusions: Combined tPA and anti-VEGF therapy is effective in managing SMH in nAMD patients, significantly improving visual acuity and SMH displacement. The location of tPA and anti-VEGF delivery did not significantly impact outcomes.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal Thickness in healthy eyes measured by Widefield Optical Coherence Tomography. 通过宽视场光学相干断层扫描测量健康眼睛的脉络膜厚度。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-03-17 DOI: 10.1159/000538129

Blanca Eslava, Sofia Bryan, Mariluz Puertas, Jorge Ruiz Medrano, José M Ruiz-Moreno

{"title":"Choroidal Thickness in healthy eyes measured by Widefield Optical Coherence Tomography.","authors":"Blanca Eslava, Sofia Bryan, Mariluz Puertas, Jorge Ruiz Medrano, José M Ruiz-Moreno","doi":"10.1159/000538129","DOIUrl":"10.1159/000538129","url":null,"abstract":"Introduction: The choroid and its role in posterior segment pathology has become an increasing subject of study. The objective of the present study was to analyze choroidal thickness (CT) in healthy eyes by widefield (WF) optical coherence tomography (OCT) up to the periphery and to compare the reliability of manual versus automatic measurement.Methods: Cross-sectional and non-interventional study conducted on 191 healthy eyes of 101 patients. All patients were scanned by using WF-OCT (Xephilio WF-OCT S1; Canon Corp, Tokyo, Japan). CT was measured in 2000 µm intervals automatically using the built-in software and manually by two masked observers. All analyses were performed using the IBM-PSSS statistical software program (IBM-SPSS, v. 28.0.0.0, Chicago, IL, USA).Results: CT was measured in 100% of the sample. The mean age of the study cohort was 39.05±19.06 years old. Mean subfoveal (SF)CT measured automatically was 343.67±84.18 μm and manually was 336.55±75.57 μm. The thickest point was located 2000 μm from the fovea in the superior sector in 62.83% of the subjects. According to age distribution, mean CT became significantly thinner from 40 years of age. When comparing automatic and manually measuring, the intraclass correlation coefficient was excellent (p<0.01) in all quadrants. Moreover, manual measurement interobserver agreement was excellent in all quadrants (p<0.01).Conclusion: The automatic system is valid and serves as the basis of choroid measurement. In more than 50% of the healthy subjects, superior CT is thicker than subfoveolar CT and mean CT became significantly thinner from 40 years of age.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0