Ophthalmologica最新文献

{"title":"OCT-Derived Biomarkers in Optic Disc Pit Maculopathy Are Associated with Age, Visual Function, and Natural History.","authors":"Edward Bloch, Blanca C Flores-Sánchez, Odysseas Georgiadis, Conor M Ramsden, Lyndon da Cruz","doi":"10.1159/000545664","DOIUrl":"10.1159/000545664","url":null,"abstract":"<p><strong>Introduction: </strong>Optic disc pit maculopathy (ODP-M) describes the variable intra- (IRF) and/or subretinal fluid (SRF) accumulation complicating a congenital optic disc anomaly that is primarily observed in young adults. This study aimed to explore the morphological variance in ODP-M, in order to measure associations between demographic and functional characteristics and investigate the natural course of the disease.</p><p><strong>Methods: </strong>A single-centre, retrospective, observational study was performed. Subjects with ODP-M were identified through electronic notes review. Demographic characteristics, visual acuity, and anatomical features were analysed with respect to a predefined OCT-based sub-categorisation: type 1a: IRF only; type 1b: IRF + outer lamellar hole (OLH) +/- SRF; type 2: SRF +/- IRF (no OLH).</p><p><strong>Results: </strong>Fifty eyes (50 subjects) were sub-categorised according to fluid distribution into type 1a (34%), type 1b (28%), and type 2 ODP-M (38%). Those with type 2 were found to be significantly younger than those with types 1a/b ODP-M (p < 0.001) and accounted for 93% of cases occurring in subjects ≤20 years old. The presence of OLH (i.e., type 1b) was noted to be independently associated with worse final VA (p = 0.013) and higher likelihood of proceeding to surgery (p = 0.002).</p><p><strong>Conclusion: </strong>There appears to be an age-related variation in ODP-M morphology, indicating the possibility of separate pathoanatomical processes, with distinct clinical courses and potentially different optimal management strategies. Sub-categorisation of ODP-M according to the reported structural features may help guide management of this rare condition.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autosomal Dominant RP1 c.2613dupA (p.Arg872Thrfs*2) Variant Retinitis Pigmentosa Shows Linear Loss of the Ellipsoid Zone over Time with Highly Variable Phenotype.","authors":"Nastasia Foa, Maximilian Pfau, Georg Ansari, Giuseppe Cancian, Gabriela Grimaldi, Samuel Koller, Wolfgang Berger, Pascal Escher, Lucas Janeschitz-Kriegl, Carlo Rivolta, Hendrik P N Scholl, Moreno Menghini","doi":"10.1159/000545606","DOIUrl":"10.1159/000545606","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to report the phenotype and progression pattern of RP1 retinitis pigmentosa carrying the variant c.2613dupA (p.Arg872Thrfs*2).</p><p><strong>Methods: </strong>This is a retrospective cohort study from 13 families with confirmed RP1 c.2613dupA (p.Arg872Thrfs*2) variant. Analysis was performed on clinical data including multimodal imaging and visual function tests. Progression rate (PR) was defined as the length of ellipsoid zone (EZ) lost per year and was calculated for all patients. Linear mixed model to predict the diameter of EZ loss as a function of age was applied.</p><p><strong>Results: </strong>Twenty-one patients were included in the study. EZ loss in all patients ranged from 3.8 to 576.0 µm/year (median PR 76.5, IQR 97.6) in right eyes and from 26.6 to 340.7 µm/year (median PR 96.6, IQR 70.3), in left eyes, respectively, with a linear slope of progression for both eyes. The linear mixed model using age as an explanatory variable explained 25% of the variability in PR and showed that male patients had on average a statistically significant smaller EZ diameter at baseline.</p><p><strong>Conclusion: </strong>The rate of progression of RP1 as measured by loss of EZ appears to be linear, independent of the age of onset. Furthermore, it appears that male subjects may present with earlier onset of disease as they showed a statistically significant smaller EZ diameter at baseline. Monitoring of EZ loss could be a valid clinical surrogate marker for clinical trials, but possibly sex differences and high variability of phenotypes need to be considered.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyes on the Text: Assessing Readability of Artificial Intelligence and Ophthalmologist Responses to Patient Surgery Queries.","authors":"Sai S Kurapati, Derek J Barnett, Antonio Yaghy, Cameron J Sabet, David N Younessi, Dang Nguyen, John C Lin, Ingrid U Scott","doi":"10.1159/000544917","DOIUrl":"10.1159/000544917","url":null,"abstract":"<p><strong>Introduction: </strong>Generative artificial intelligence (AI) technologies like GPT-4 can instantaneously provide health information to patients; however, the readability of these outputs compared to ophthalmologist-written responses is unknown. This study aimed to evaluate the readability of GPT-4-generated and ophthalmologist-written responses to patient queries about ophthalmic surgery.</p><p><strong>Methods: </strong>This retrospective cross-sectional study used 200 randomly selected patient questions about ophthalmic surgery extracted from the American Academy of Ophthalmology's EyeSmart platform. The questions were inputted into GPT-4, and the generated responses were recorded. Ophthalmologist-written replies to the same questions were compiled for comparison. Readability of GPT-4 and ophthalmologist responses was assessed using six validated metrics: Flesch Kincaid Reading Ease (FK-RE), Flesch Kincaid Grade Level (FK-GL), Gunning Fog Score (GFS), SMOG Index (SI), Coleman Liau Index (CLI), and Automated Readability Index (ARI). Descriptive statistics, one-way ANOVA, Shapiro-Wilk, and Levene's tests (α = 0.05) were used to compare readability between the two groups.</p><p><strong>Results: </strong>GPT-4 used a higher percentage of complex words (24.42%) compared to ophthalmologists (17.76%), although mean (standard deviation) word count per sentence was similar (18.43 [2.95] and 18.01 [6.09]). Across all metrics (FK-RE; FK-GL; GFS; SI; CLI; and ARI), GPT-4 responses were at a higher grade level (34.39 [8.51]; 13.19 [2.63]; 16.37 [2.04]; 12.18 [1.43]; 15.72 [1.40]; 12.99 [1.86]) than ophthalmologists' responses (50.61 [15.53]; 10.71 [2.99]; 14.13 [3.55]; 10.07 [2.46]; 12.64 [2.93]; 10.40 [3.61]), with both sources necessitating a 12th-grade education for comprehension. ANOVA tests showed significance (p < 0.05) for all comparisons except word count (p = 0.438).</p><p><strong>Conclusion: </strong>The National Institutes of Health advises health information to be written at a 6th- to 7th-grade level. Both GPT-4- and ophthalmologist-written answers exceeded this recommendation, with GPT-4 showing a greater gap. Information accessibility is vital when designing patient resources, particularly with the rise of AI as an educational tool.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious Causes of Retinal Vasculitis: Causes, Presentation, Differentiation, and Therapy.","authors":"Ariel Schlaen, Juliana Montoya, Milagros Heredia, Sebastián Inchauspe, Emilio M Dodds","doi":"10.1159/000545044","DOIUrl":"10.1159/000545044","url":null,"abstract":"<p><strong>Background: </strong>Retinal vasculitis is a common manifestation of infections affecting the posterior segment. The purpose of this review was to describe the main characteristics of infectious retinal vasculitis, with an emphasis on its associated specific clinical manifestations.</p><p><strong>Summary: </strong>Retinal vasculitis is usually associated with retinal or choroidal involvement when infectious etiology is present. It may be caused by bacterial, viral, fungal, or parasitic infection. Its prevalence and the spectrum of etiologies show geographical variations. Infectious vasculitis tends to exhibit ischemic areas, arterial or venous sheathing or occlusion, while noninfectious retinal vasculitis is predominantly associated with capillary vasculitis.</p><p><strong>Key messages: </strong>Recognizing the features of infectious retinal vasculitis, along with associated ocular and systemic signs, patient habits, and origin, enables the physician to suspect the potential causative etiology of the condition, facilitating more effective management of affected patients.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-29"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes of Vitrectomy with Gas or Silicone Oil Tamponade for Giant Retinal Tears.","authors":"Arielle Benchimol, Paul Denys, Raphaël Lejoyeux, Sébastien Bruneau, Sophie Bonnin, Aude Couturier","doi":"10.1159/000545042","DOIUrl":"10.1159/000545042","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of the study were to assess the long-term anatomic and functional outcomes in giant retinal tear (GRT)-associated retinal detachment (GRT-RD) and identify factors associated with recurrence.</p><p><strong>Methods: </strong>This is a retrospective monocentric study of the patients treated for GRT-RD between 2017 and 2022 at Rothschild Foundation Hospital, Paris, France.</p><p><strong>Results: </strong>A total of 65 eyes from 64 patients were analyzed with a mean follow-up of 21.5 months. The mean age was 52.7 years and 89.2% of them were men. 69.3% of eyes were phakic, the mean axial length was 25.4 mm, and 15 eyes had high myopia. The mean size of the GRT was 147.7°. Macula was attached in 33 cases. All the patients underwent pars plana vitrectomy. Perfluorocarbon liquids were used in almost all cases. Retinopexy was then performed. Silicone oil tamponade was used in 47 eyes and gas tamponade was used in 18 eyes (27.7%). Recurrence of RD occurred in 15 eyes. Factors associated with a recurrence of the RD were macula-off detachment and the presence of another retinal tear. No significant differences were made between silicone oil or gas tamponade in terms of recurrence. No significant difference was shown in postoperative outcomes between the two groups of tamponades.</p><p><strong>Conclusion: </strong>GRT-RD remains serious with a recurrence rate of 23% in this series. Whereas gas tamponade is less frequently used, its use showed no significant difference compared to silicone oil in terms of postoperative outcomes, and no difference in risk of recurrence of RD in this study.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networking of Eye Hospitals on a National Level for Promoting and Advancing Conduct of Clinical Trials.","authors":"Barbara J Wilhelm, Frank G Holz, Katrin Lorenz","doi":"10.1159/000543727","DOIUrl":"10.1159/000543727","url":null,"abstract":"<p><strong>Purpose: </strong>The complexity of clinical trials is increasing for both sponsors and study sites. This impacts planning, preparation, implementation, and conduct of all studies. The exchange of experience and cooperation helps centers to better master the various challenges facing ophthalmological study centers. This serves the efficiency of multicenter studies, including timely patient recruitment.</p><p><strong>Methods: </strong>The DOG (German Society of Ophthalmology) Clinical Study Centers Working Group (WG) was founded in 2011. Since then, regular meetings have been held including the annual during the DOG and meeting. There is also a continuous exchange in between these meetings. Symposia are regularly held at the DOG conferences together with industry and regulatory authorities. A range of courses on the conduct clinical trials has been established, and joint publications and DOG recommendations are regularly generated.</p><p><strong>Results: </strong>Since its foundation, the WG has tremendously gained visibility and popularity. Its members have increased from 40 (2011) to 80 (2024). Study-specific recommendations were produced early on, which were published by the DOG in German and English language. The topics of the publications and symposia range from study design, budget negotiations, special challenges, publication regulations, and legislation to the attractiveness of Germany as a study location. Since 2023, a patient video of the WG has been available to support and foster recruitment of study patients.</p><p><strong>Conclusion: </strong>The DOG Working Group Clinical Study Centers has become a platform for cooperation and representation of the interests of German ophthalmological study centers. It also represents an important link to industry and is engaged in a lively dialogue to promote Germany as a study location in ophthalmology. The group and its activities may serve as a model for other medical societies and countries.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Coherence Tomography Imaging of Perforating Scleral Vessels and Dilated Choroidal Veins as Potential Image Markers in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography.","authors":"Jorge Ruiz-Medrano, Elena Almazán-Alonso, Mariluz Puertas, Ignacio Flores-Moreno, María García-Zamora, Bachar Kudsieh, José M Ruiz-Moreno","doi":"10.1159/000544750","DOIUrl":"10.1159/000544750","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to analyze the role of perforating scleral vessel (PSV) and dilated choroidal veins (DCVs) underneath macular myopic choroidal neovascularization (mCNV).</p><p><strong>Methods: </strong>This retrospective case-control study analyzed 78 eyes from 78 highly myopic patients defined by an axial length (AL) of ≥26 mm, assessed by optical coherence tomography (OCT) and OCT angiography (OCTA) imaging. Patients with clinical diagnosis of mCNV and good-quality OCTA images were selected. Swept source (SS)-OCT and SS-OCTA images (Triton; Topcon Corporation, Tokyo, Japan) were reviewed to detect image markers in the mCNV area. Highly myopic eyes without mCNV, matched by age and AL, were used as control group. The presence of PSV and DCV was recorded. Myopic maculopathy was graded using the atrophic, traction, and neovascularization (ATN) classification.</p><p><strong>Results: </strong>Seventy-eight eyes from 78 patients (39 with mCNV and 39 without mCNV) were included, out of the total 775 eyes screened. Fifty-nine (75.6%) of them were women. The mean ATN grading of myopic maculopathy was compared between eyes with mCNV and those without mCNV: atrophy scores were 2.71 ± 0.97 versus 2.30 ± 0.89, respectively (p = 0.04); traction scores were 0.64 ± 0.66 versus 0.84 ± 0.98, respectively (p = 0.54); and neovascularization scores were 2.00 ± 0.00 versus 0.33 ± 0.73, respectively (p < 0.001). The presence of OCT imaging markers did not significantly differ between groups; i.e., PSV was found in 34/39 versus 32/39 (p = 0.53) eyes, and DCV was found in 11/39 versus 7/39 eyes, mCNV versus control group, respectively (p = 0.28).</p><p><strong>Conclusions: </strong>PSV and DCV are image markers present in a high number of highly myopic eyes, which are not specific to mCNV.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane.","authors":"Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya","doi":"10.1159/000542214","DOIUrl":"10.1159/000542214","url":null,"abstract":"<p><strong>Introduction: </strong>We investigated the changes of peripapillary and macular microvasculature in idiopathic macular epiretinal membrane (iERM) eyes before and after pars plana vitrectomy (PPV), aiming to identify potential optical coherence tomography angiography (OCTA) predictors of visual acuity improvement.</p><p><strong>Methods: </strong>Fifty-seven eyes diagnosed with iERM were enrolled and underwent PPV with ERM and internal limiting membrane (ILM) peeling. Data were collected before surgery and during the 12-month postoperative period. OCTA analysis focused on radial peripapillary capillary (RPC) vessel density (VD), superficial and deep capillary plexus (SCP and DCP, respectively). Functional and OCT structural outcomes, including best-corrected visual acuity (BCVA) and macular thickness, were also recorded.</p><p><strong>Results: </strong>Multivariate linear regression analysis revealed that higher preoperative RPC VD, lower SCP VD, and lower BCVA were predictors of postoperative BCVA improvement (p < 0.001, p = 0.047, and p < 0.001, respectively). Throughout the follow-up period, there was an observed increase in intradisc RPC VD, whole-disc VD, and parafoveal DCP VD (all p < 0.001). BCVA and central macular thickness demonstrated significant improvement (p < 0.001) within the first month following vitrectomy, which then stabilized from the third month onward.</p><p><strong>Conclusions: </strong>Preoperative microvascular measurements in iERM patients can forecast postoperative BCVA. OCTA findings reveal that both increased RPC density and reduced SCP density at baseline could serve as predictors of better visual outcomes after surgery. Enhanced RPC density may reflect a healthier optic nerve with greater potential for visual recovery, while a less dense SCP could indicate less iERM contraction, both contributing to more favorable postoperative visual results.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"54-66"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone Oil Inhibits Early Bacterial Expansion in an in vitro Model of Intraocular Tamponade.","authors":"Eun Young Choi, Kang Hyun Kim, Hyukmin Lee, Min Kim","doi":"10.1159/000541811","DOIUrl":"10.1159/000541811","url":null,"abstract":"<p><strong>Introduction: </strong>Infectious endophthalmitis, a vision-threatening disease caused by exogenous or endogenous microbial invasion, may require vitrectomy with or without silicone oil (SO) tamponade in severe cases. SO antimicrobial effects have been suggested but not demonstrated in an in vitro environment mimicking real clinical conditions. Using an in vitro intraocular tamponade model, we investigated the antimicrobial activity of SO against 11 bacterial and 1 fungal species, including antibiotic-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae.</p><p><strong>Methods: </strong>Following inoculation, assay plates were coated with SO or balanced salt solution or left uncoated. Colony-forming units were measured 24, 48, and 72 h after incubation and compared among the three media types and three timepoints for each strain. Differences in colony size were assessed using quantitative image analysis.</p><p><strong>Results: </strong>At early incubation, methicillin-sensitive and methicillin-resistant S. aureus and Staphylococcus epidermidis, and cephalosporin-sensitive and cephalosporin-resistant K. pneumoniae and Acinetobacter baumannii colonies were significantly smaller in the SO-coated than in the control media. The number of colony-forming units showed no significant differences between SO-coated and control media for all tested species.</p><p><strong>Conclusion: </strong>SO demonstrated an inhibitory effect on the early colony expansion of certain aerobic bacteria, including antibiotic-resistant bacterial strains, but does not have a bactericidal effect. Therefore, the use of SO tamponade should be primarily determined by the clinical presentation and intraoperative retinal findings during surgery, rather than its potential antimicrobial effects.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"73-80"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Traumatic Macular Hole and Orbital Fracture.","authors":"Jonnah Kristina Teope, Mayari Ito, Jose Miguel Ambat, Yasuhiro Takahashi","doi":"10.1159/000543232","DOIUrl":"10.1159/000543232","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to report 5 cases of concomitant traumatic macular hole (TMH) and orbital fracture and discuss its incidence.</p><p><strong>Methods: </strong>This was a retrospective, observational study including all patients with orbital fracture who were referred to us from May 2013 to December 2023. Axial and coronal orbital computed tomographic images with bone and soft tissue window algorithms and optical coherence tomographic images were obtained from all patients.</p><p><strong>Results: </strong>Among 1,171 sides from 1,152 patients with pure orbital blowout fractures, we found 5 sides from 5 patients (0.4%) with concomitant TMH. All trauma was caused by baseball/softball injury. One patient had a medial orbital wall fracture with TMH stage 1b. Two had orbital floor fracture with TMH stages 2 and 3. The other two had both orbital floor and medial orbital wall fractures with TMH stages 3 and 4. Orbital fracture was reduced in 3 patients. Two had spontaneous closure of TMH with no improvement in visual acuity, while one improved with pars plans vitrectomy and internal limiting membrane peeling.</p><p><strong>Conclusion: </strong>The incidence of concomitant TMH and orbital fracture is only 0.4%. The rarity of this association supports the protective role of orbital fractures in blunt trauma. Specific mechanisms of trauma, such as impacts from baseballs and softballs, may increase the risk of such injuries.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"67-72"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}