Ophthalmologica最新文献

Brolucizumab for Wet Age-related Macular Degeneration in Switch Patients: Long-Term Real-World Experience from a Tertiary Center. Brolucizumab用于开关患者湿性年龄相关性黄斑变性：来自三级中心的长期真实世界经验。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-09-17 DOI: 10.1159/000547471

Andrea Scupola, Lorenzo Hu, Mattia Cusato, Claudia Fossataro, Marzia Michieletto, Maria Grazia Sammarco, Stanislao Rizzo, Gustavo Savino

{"title":"Brolucizumab for Wet Age-related Macular Degeneration in Switch Patients: Long-Term Real-World Experience from a Tertiary Center.","authors":"Andrea Scupola, Lorenzo Hu, Mattia Cusato, Claudia Fossataro, Marzia Michieletto, Maria Grazia Sammarco, Stanislao Rizzo, Gustavo Savino","doi":"10.1159/000547471","DOIUrl":"https://doi.org/10.1159/000547471","url":null,"abstract":"Objective: To evaluate the three-year real-world efficacy and safety of intravitreal brolucizumab injections in patients with neovascular age-related macular degeneration (nAMD) who switched from other anti-vascular endothelial growth factor (VEGF) therapies.Design: Retrospective, single-center, observational cohort study.Subjects: The study included 97 eyes of 91 patients with nAMD previously treated with anti-VEGF therapies who completed three years of follow-up.Methods: Patients received intravitreal injections of 6 mg brolucizumab. Data on Best Corrected Visual Acuity (BCVA), Central Subfield Thickness (CST), Intraretinal Fluid (IRF), Subretinal Fluid (SRF), sub-Retinal Pigment Epithelium Fluid (sRPEF), treatment intervals, and adverse events were collected over a three-year follow-up period.Results: The mean age of patients was 78.9±8.2 years, with a mean follow-up of 161.3 weeks. At three-year follow up, mean BCVA significantly improved, from 41.1±6.5 at baseline to 50.7±7.5 ETDRS letters (p<0.001), and mean CST significantly decreased from 371.3±136.7 to 299.1±137.81 (p<0.001). Significant reductions were observed in IRF (p<0.001), SRF (p<0.001), and sRPEF (p=0.004). Mean injections per year were 4.7±1.9, 3.9±1.7, and 3.6±1.9 in the first, second, and third years, respectively. Adverse events were noted in four patients after either the first or second injection, with no further events reported.Conclusion: This study reports that brolucizumab provides favorable anatomical and functional outcomes and can reduce treatment burden in patients with nAMD due to its rapid and sustained efficacy and favorable safety profile.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-20"},"PeriodicalIF":1.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of long-term outcomes of submacular hemorrhage in AMD: a real-life study. 黄斑下出血的长期预后比较分析：一项现实研究。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-09-13 DOI: 10.1159/000548392

Nicolas Chirpaz, Benjamin Matagrin, Lucas Gauthier, Sandra Elbany, Antonin Rocher, Thibaud Mathis, Inès Fenniri, Philippe Denis, Laurent Kodjikian, Carole Burillon, Corinne Dot

{"title":"Comparative analysis of long-term outcomes of submacular hemorrhage in AMD: a real-life study.","authors":"Nicolas Chirpaz, Benjamin Matagrin, Lucas Gauthier, Sandra Elbany, Antonin Rocher, Thibaud Mathis, Inès Fenniri, Philippe Denis, Laurent Kodjikian, Carole Burillon, Corinne Dot","doi":"10.1159/000548392","DOIUrl":"https://doi.org/10.1159/000548392","url":null,"abstract":"Introduction Submacular hemorrhage (SMH) is a severe complication of neovascular age-related macular degeneration (nAMD), often causing profound vision loss. The aim of this study was to assess the long-term outcomes of SMH patients managed with anti-VEGF monotherapy (MT) versus surgical displacement (SD) and to identify prognostic factors for visual acuity. Methods This multicenter retrospective study included patients with SMH secondary to nAMD treated in three hospitals in Lyon between 2018 and 2023. Patients were treated with MT or underwent pneumatic displacement (PD) or SD. The best-corrected visual acuity (BCVA) and clinical parameters were assessed at baseline (time of SMH onset), months 1, 3, 9 and 12. Results Sixty-six eyes were included: 33 received MT, 6 underwent PD, and 27 underwent SD. The baseline VA was strongly reduced (mean BCVA: 0.14). The VA improved to 0.21 at M1, 0.29 at M3, and 0.33 at M6 but was stabilized at 0.28 at M12. At M12, VA did not significantly differ between MT and SD groups (0.27 vs. 0.32, p = 0.624). However, multivariate analysis revealed a significantly greater VA gain in the SD group (p = 0.025), despite more severe baseline characteristics. SMH thickness was significantly associated with a poorer VA (p=0.02). Conclusion Surgical displacement may offer greater visual improvement in cases of large and thick SMH. Maximum SMH thickness appears to be a key prognostic factor. Treatment decisions should consider initial hemorrhage severity.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Intraoperative Early Positioning on Anatomical Success after Inverted Flap Technique in Large Macular Holes: A Retrospective Comparative Study. 术中早期定位对黄斑大孔逆行皮瓣手术解剖成功的影响：回顾性比较研究。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-08-08 DOI: 10.1159/000547711

Fikret Ucar, Ekrem Kadıoğlu

{"title":"Impact of Intraoperative Early Positioning on Anatomical Success after Inverted Flap Technique in Large Macular Holes: A Retrospective Comparative Study.","authors":"Fikret Ucar, Ekrem Kadıoğlu","doi":"10.1159/000547711","DOIUrl":"10.1159/000547711","url":null,"abstract":"Introduction: In this study, we wanted to evaluate the effect of intraoperative early positioning on anatomical success in patients with large macular holes undergoing the inverted flap (IF) technique.Methods: This retrospective, comparative study included 43 patients diagnosed with a macular hole ≥400 μm in minimum linear diameter who underwent pars plana vitrectomy using the IF technique. Patients were allocated chronologically into two groups: those operated on prior to February 2020 formed the standard positioning group (n = 23), and those treated thereafter composed the early positioning group (n = 20). In the early intraoperative positioning group, the patient's head was turned nasally immediately after the air-fluid exchange to stabilize the IF. In contrast, the standard group followed conventional postoperative prone positioning. The primary outcome was complete macular hole closure, assessed using optical coherence tomography. Secondary outcomes included IF stability, retinal layer integrity, and the need for additional postoperative surgical interventions.Results: At postoperative month 3, anatomical closure was achieved in all patients (100%) in the early positioning group, compared to 85% in the standard group (p = 0.05). Flap dislocation occurred in 15% of patients in the standard group, while none was observed in the early group (p = 0.05). Preoperative BCVA was 0.67 ± 0.28 logMAR in the early group and 0.65 ± 0.28 logMAR in the standard group (p = 0.74). Postoperative BCVA improved to 0.07 ± 0.08 logMAR and 0.16 ± 0.22 logMAR, respectively (p = 0.09).Conclusion: Intraoperative early positioning significantly improves anatomical outcomes in large macular hole surgery by enhancing flap stability and promoting successful closure.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Internal Limiting Membrane Peeling in Eyes with Proliferative Diabetic Retinopathy: A Meta-Analysis. 增殖性糖尿病视网膜病变眼内限制性膜剥离的疗效：荟萃分析。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-07-14 DOI: 10.1159/000547416

Bahram Bodaghi, Sarah Touhami, Yoo-Ri Chung, Eunzee Lee, Hanju Kim

{"title":"Efficacy of Internal Limiting Membrane Peeling in Eyes with Proliferative Diabetic Retinopathy: A Meta-Analysis.","authors":"Bahram Bodaghi, Sarah Touhami, Yoo-Ri Chung, Eunzee Lee, Hanju Kim","doi":"10.1159/000547416","DOIUrl":"10.1159/000547416","url":null,"abstract":"Introduction: We investigated the effects of internal limiting membrane (ILM) peeling on treating posterior segment complications other than macular edema in patients with proliferative diabetic retinopathy (PDR) treated with vitrectomy.Methods: Databases including PubMed, EMBASE, and Cochrane Library were searched on October 2, 2023. Studies comparing patients with PDR who were treated with ILM peeling to those who did not undergo ILM peeling were included. The primary outcome was the final best-corrected visual acuity (BCVA). Secondary outcomes were final central retinal thickness (CRT) and formation of the postoperative epiretinal membrane (ERM).Results: Eleven comparative studies were included in this meta-analysis. The postoperative BCVA at 6 months was better in those who underwent ILM peeling (95% confidence interval [CI]: -0.51 to -0.15) than in those did not, whereas the final BCVA was not significantly different between the groups (95% CI: -0.30 to 0.00). The final CRT was significantly thin (95% CI: -61.82 to -35.63), with a low occurrence of postoperative ERM in the ILM peeling group (95% CI: 0.12-0.26).Conclusion: ILM peeling effectively prevented postoperative ERM formation in patients with PDR complications; however, the benefit for postoperative vision was not evident after 6 months.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Readability of AI and Ophthalmologist Responses to Patient Surgery Queries: Comment" by Daungsupawong and Wiwanitkit. Daungsupawong和Wiwanitkit对“人工智能的可读性和眼科医生对患者手术问题的回应：评论”的回应。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2025-04-29 DOI: 10.1159/000546049

Sai S Kurapati, Antonio Yaghy, Derek J Barnett, Ingrid U Scott

引用次数: 0

Readability of AI and Ophthalmologist Responses to Patient Surgery Queries: Comment. 人工智能的可读性与眼科医生对患者手术问题的回答：评论。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2025-04-17 DOI: 10.1159/000545970

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane. 用玻璃体切除术治疗特发性视网膜外膜患者视力改善的毛细血管周围和黄斑 OCTA 预测因子

IF 2.1 4区医学

Ophthalmologica Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1159/000542214

Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya

{"title":"Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane.","authors":"Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya","doi":"10.1159/000542214","DOIUrl":"10.1159/000542214","url":null,"abstract":"Introduction: We investigated the changes of peripapillary and macular microvasculature in idiopathic macular epiretinal membrane (iERM) eyes before and after pars plana vitrectomy (PPV), aiming to identify potential optical coherence tomography angiography (OCTA) predictors of visual acuity improvement.Methods: Fifty-seven eyes diagnosed with iERM were enrolled and underwent PPV with ERM and internal limiting membrane (ILM) peeling. Data were collected before surgery and during the 12-month postoperative period. OCTA analysis focused on radial peripapillary capillary (RPC) vessel density (VD), superficial and deep capillary plexus (SCP and DCP, respectively). Functional and OCT structural outcomes, including best-corrected visual acuity (BCVA) and macular thickness, were also recorded.Results: Multivariate linear regression analysis revealed that higher preoperative RPC VD, lower SCP VD, and lower BCVA were predictors of postoperative BCVA improvement (p < 0.001, p = 0.047, and p < 0.001, respectively). Throughout the follow-up period, there was an observed increase in intradisc RPC VD, whole-disc VD, and parafoveal DCP VD (all p < 0.001). BCVA and central macular thickness demonstrated significant improvement (p < 0.001) within the first month following vitrectomy, which then stabilized from the third month onward.Conclusions: Preoperative microvascular measurements in iERM patients can forecast postoperative BCVA. OCTA findings reveal that both increased RPC density and reduced SCP density at baseline could serve as predictors of better visual outcomes after surgery. Enhanced RPC density may reflect a healthier optic nerve with greater potential for visual recovery, while a less dense SCP could indicate less iERM contraction, both contributing to more favorable postoperative visual results.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"54-66"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Ectopic Inner Foveal Layer on Optical Coherence Tomography and Postoperative Quantitative Metamorphopsia in Patients Undergoing Epiretinal Membrane Surgery. 光学相干断层扫描异位内中央凹层与视网膜前膜手术患者术后定量变形的关系。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1159/000546248

Lamberto La Franca, Micol Alkabes, Andrea Muraca, Lamberto La Franca, Alessandro Rabiolo, Paolo Fogagnolo, Stefano Ranno, Filippo Frerio, Mattia Marchetti, Davide Wild, Valentina Gatti, Stefano De Cillà

{"title":"Association between Ectopic Inner Foveal Layer on Optical Coherence Tomography and Postoperative Quantitative Metamorphopsia in Patients Undergoing Epiretinal Membrane Surgery.","authors":"Lamberto La Franca, Micol Alkabes, Andrea Muraca, Lamberto La Franca, Alessandro Rabiolo, Paolo Fogagnolo, Stefano Ranno, Filippo Frerio, Mattia Marchetti, Davide Wild, Valentina Gatti, Stefano De Cillà","doi":"10.1159/000546248","DOIUrl":"10.1159/000546248","url":null,"abstract":"Introduction: Epiretinal membrane (ERM) is a condition that can lead to visual impairment and metamorphopsia. This study aimed to examine the correlation between metamorphopsia and foveal microstructure before and after macular surgery in a cohort of patients with advanced ERM.Methods: The severity of metamorphopsia was quantified using M-CHARTS, and foveal microstructure was evaluated via two optical coherence tomography (OCT) measures: central foveal thickness and ectopic inner foveal layer (EIFL). Assessments were performed pre- and post-surgery with an average follow-up of 1 year. Correlations between morphological and functional parameters pre- and post-surgery were explored by means of regression analysis.Results: Sixty eyes of 57 patients diagnosed with advanced ERM and surgically treated were included in the study. Our findings showed a significant correlation between postoperative metamorphopsia and both pre- (R2 = 0.431) and postoperative (R2 = 0.300) EIFL thickness. Disparities were observed in metamorphopsia scores between patients with ERM stages 3 and 4, both pre- (0.46 ± 0.31 and 0.84 ± 0.32, respectively, p < 0.01) and post-surgery (0.18 ± 0.21 and 0.46 ± 0.28, respectively, p < 0.01). Postoperative EIFL thickness was the only variable significantly associated with postoperative metamorphopsia scores according to multiple regression analysis.Conclusion: EIFL thickness emerges as a critical determinant of postoperative metamorphopsia severity, underscoring its importance in predicting functional outcomes after ERM surgery. Although surgery improved metamorphopsia across stages, patients with more advanced ERM experienced less favorable outcomes, stressing the importance of a timely surgical intervention.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"239-248"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited Progression of Nuclear Sclerosis after Lens-Sparing Vitrectomy in Proliferative Diabetic Retinopathy Eyes: A Real-World Investigation with Scheimpflug Lens Densitometry. 增殖性糖尿病视网膜病变眼保留晶状体玻璃体切除术后核硬化的有限进展：一项使用Scheimpflug晶状体密度测定法的真实世界调查。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-01-01 Epub Date: 2025-06-18 DOI: 10.1159/000546292

Luca Mautone, Patrick Fisel, Vasyl Druchkiv, Nefeli Eleni Kounatidou, Philipp Schindler, Martin Stephan Spitzer, Christos Skevas

{"title":"Limited Progression of Nuclear Sclerosis after Lens-Sparing Vitrectomy in Proliferative Diabetic Retinopathy Eyes: A Real-World Investigation with Scheimpflug Lens Densitometry.","authors":"Luca Mautone, Patrick Fisel, Vasyl Druchkiv, Nefeli Eleni Kounatidou, Philipp Schindler, Martin Stephan Spitzer, Christos Skevas","doi":"10.1159/000546292","DOIUrl":"10.1159/000546292","url":null,"abstract":"Introduction: The objective of this study was to objectively investigate the progression of lens nuclear sclerosis after lens spearing pars plana vitrectomy (PPV) in patients with proliferative diabetic retinopathy (PDR).Methods: Comparison of Pentacam HR® Scheimpflug imaging-based lens densitometry (LD) of eyes with PDR-associated tractive retinal detachment (study group) and nondiabetic eyes with rhegmatogenous retinal detachment (control group) after lens-sparing PPV.Results: Fifty-nine eyes of 55 subjects treated with gas (GT; 29 eyes in the study and 30 in the control group; mean follow-up: 381.41 [±309.17] days) and 42 eyes of 41 subjects treated with silicone oil tamponade (SOT; 10 eyes in the Study and 32 in the control group; mean follow-up: 326.50 [±239.59] days) were included. The prediction model for postoperative LD progression indicated that the increase in LD was lower in the study group than in the control group, regardless of the type of tamponade used. A second adjusted prediction model, including only age and baseline LD-matched eyes, further confirmed that the study group experienced a lower increase in LD in both SOT and GT cases than the control group.Conclusion: The increase in lens nuclear sclerosis is more pronounced in nondiabetic eyes than in those with PDR after lens-sparing vitrectomy. These findings support the hypothesis that ischemia in PDR may protect against the development of nuclear cataracts following PPV.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"284-293"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Intravitreal Aflibercept 2 mg Treatment of Macular Oedema Secondary to Retinal Vein Occlusion in Italy: 24-Month Results from the AURIGA Observational Study. 在意大利，阿非利赛普2mg玻璃体内治疗继发于视网膜静脉阻塞的黄斑水肿：来自AURIGA观察研究的24个月结果。

IF 1.9 4区医学

Ophthalmologica Pub Date : 2025-01-01 Epub Date: 2025-04-09 DOI: 10.1159/000545534

Maria Oliva Grassi, Andrea Russo, Maria Vadalà, Helmut Allmeier, Tobias Machewitz, Monica Varano

{"title":"Real-World Intravitreal Aflibercept 2 mg Treatment of Macular Oedema Secondary to Retinal Vein Occlusion in Italy: 24-Month Results from the AURIGA Observational Study.","authors":"Maria Oliva Grassi, Andrea Russo, Maria Vadalà, Helmut Allmeier, Tobias Machewitz, Monica Varano","doi":"10.1159/000545534","DOIUrl":"10.1159/000545534","url":null,"abstract":"Introduction: This subgroup analysis of the global AURIGA study evaluated intravitreal aflibercept 2 mg (IVT-AFL) effectiveness and treatment patterns in routine practice in Italy in patients with macular oedema secondary to branch or central retinal vein occlusion (BRVO/CRVO).Methods: AURIGA (NCT03161912) was a 24-month, prospective observational study in patients for whom IVT-AFL treatment had already been prescribed by their physician. All clinical decisions were according to physician discretion and local practice. Statistical analyses were descriptive only.Results: In Italy, 152 treatment-naïve and 50 pretreated patients participated across 27 centres. Mean (95% confidence interval) change in visual acuity (VA) from baseline to month 12 in treatment-naïve patients was +10.3 (7.0, 13.6) and +12.2 (5.6, 18.8) letters for BRVO and CRVO (baseline: 55.3 ± 20.3 and 44.5 ± 25.5 letters), and pretreated patients gained +6.6 (0.3, 13.0) and +14.6 (5.5, 23.8) letters for BRVO and CRVO (baseline: 56.0 ± 15.9 and 42.2 ± 23.5 letters). In treatment-naïve patients, VA gains by M12 after a mean of 4.8 injections were maintained through M24 after a mean of 5.7 injections from baseline; in pretreated patients, M12 gains were not maintained, despite a similar mean of 5.8 injections by M24. Most injections were received within the first 6 months, with a marked reduction in injection frequency thereafter.Conclusion: Robust VA improvements were observed in treatment-naïve patients with RVO in Italy following IVT-AFL treatment for up to 24 months in routine practice, despite a low injection frequency. However, guidelines indicate that regular, proactive treatment beyond the acute stage is required to improve long-term outcomes. .","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"270-283"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0