Ophthalmologica最新文献

Ultrasound Biomicroscopy in scleral fixation using Gore-Tex suture of a subluxated PCIOL. 超声生物显微镜在Gore-Tex缝合半脱位PCIOL巩膜固定中的应用。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-12-23 DOI: 10.1159/000543255

Alon Tiosano, Ruti Sella, Orly Gal-Or, Rita Zlatkin, Rita Ehrlich, Irit Bahar

{"title":"Ultrasound Biomicroscopy in scleral fixation using Gore-Tex suture of a subluxated PCIOL.","authors":"Alon Tiosano, Ruti Sella, Orly Gal-Or, Rita Zlatkin, Rita Ehrlich, Irit Bahar","doi":"10.1159/000543255","DOIUrl":"https://doi.org/10.1159/000543255","url":null,"abstract":"Introduction: The aim of our study was to assess the outcome of Gore-Tex sutures in minimally invasive scleral fixation of subluxated posterior chamber intraocular lenses (PCIOLs) and to demonstrate a method for validating the lens position.Methods: Retrospective study of patients who underwent lasso in-the-bag scleral fixation of a subluxated PCIOL using the snare technique with Gore-Tex suture from 2019 to 2021 in a single tertiary medical center. Functional outcome was analyzed by clinical assessment, and anatomical outcome, by ultrasound biomicroscopy (UBM).Results: 18 eyes were included . Mean duration of follow-up was 140 days (range 23-659), and median time from PCIOL implantation to fixation was 8.5 years (IQR 6.25-10.75). All patients had ocular comorbidities, mainly glaucoma (n=6) and pseudoexfoliation syndrome (n=5). Best corrected visual acuity improved from a median of 6/30 (0.7 logMAR) to a median of 6/12 (0.35 logMAR) (P=0.06); postoperative astigmatism measured 0.91±2.19 diopters. UBM demonstrated well-balanced PCIOL fixation with no difference between the horizontal and vertical tilt measurements (P=0.84;P=0.94;P=0.62;P=0.085). The fixated PCIOL showed < 10% decentration in reference to the visual axis. There was a high negative correlation between BCVA improvement and residual lens tilt (r=-0.76, P=0.037). Postoperative complications included transient ocular hypertension (n=3), corneal decompensation with subsequent keratoplasty (n=3), temporary hypotony (n=2), cystoid macular edema (n=1), suture exposure (n=1) and endophthalmitis(n=1).Conclusions: Subluxated PCIOLs are amenable to treatment with minimally invasive fixation using Gore-Tex suture with good anatomic outcomes. UBM image analysis may serve as a valuable method for assessing PCIOL position following scleral fixation.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-18"},"PeriodicalIF":2.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Traumatic Macular Hole and Orbital Fracture. 伴发外伤性黄斑裂孔及眼眶骨折。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-12-18 DOI: 10.1159/000543232

Jonnah Kristina Teope, Mayari Ito, Jose Miguel Ambat, Yasuhiro Takahashi

{"title":"Concomitant Traumatic Macular Hole and Orbital Fracture.","authors":"Jonnah Kristina Teope, Mayari Ito, Jose Miguel Ambat, Yasuhiro Takahashi","doi":"10.1159/000543232","DOIUrl":"10.1159/000543232","url":null,"abstract":"Introduction: The aim of the study was to report 5 cases of concomitant traumatic macular hole (TMH) and orbital fracture and discuss its incidence.Methods: This was a retrospective, observational study including all patients with orbital fracture who were referred to us from May 2013 to December 2023. Axial and coronal orbital computed tomographic images with bone and soft tissue window algorithms and optical coherence tomographic images were obtained from all patients.Results: Among 1,171 sides from 1,152 patients with pure orbital blowout fractures, we found 5 sides from 5 patients (0.4%) with concomitant TMH. All trauma was caused by baseball/softball injury. One patient had a medial orbital wall fracture with TMH stage 1b. Two had orbital floor fracture with TMH stages 2 and 3. The other two had both orbital floor and medial orbital wall fractures with TMH stages 3 and 4. Orbital fracture was reduced in 3 patients. Two had spontaneous closure of TMH with no improvement in visual acuity, while one improved with pars plans vitrectomy and internal limiting membrane peeling.Conclusion: The incidence of concomitant TMH and orbital fracture is only 0.4%. The rarity of this association supports the protective role of orbital fractures in blunt trauma. Specific mechanisms of trauma, such as impacts from baseballs and softballs, may increase the risk of such injuries.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-6"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silicone Oil Inhibits Early Bacterial Expansion in an in vitro Model of Intraocular Tamponade. 硅油在眼内填塞体外模型中抑制早期细菌扩张。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-12-11 DOI: 10.1159/000541811

Eun Young Choi, Kang Hyun Kim, Hyukmin Lee, Min Kim

{"title":"Silicone Oil Inhibits Early Bacterial Expansion in an in vitro Model of Intraocular Tamponade.","authors":"Eun Young Choi, Kang Hyun Kim, Hyukmin Lee, Min Kim","doi":"10.1159/000541811","DOIUrl":"10.1159/000541811","url":null,"abstract":"Introduction: Infectious endophthalmitis, a vision-threatening disease caused by exogenous or endogenous microbial invasion, may require vitrectomy with or without silicone oil (SO) tamponade in severe cases. SO antimicrobial effects have been suggested but not demonstrated in an in vitro environment mimicking real clinical conditions. Using an in vitro intraocular tamponade model, we investigated the antimicrobial activity of SO against 11 bacterial and 1 fungal species, including antibiotic-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae.Methods: Following inoculation, assay plates were coated with SO or balanced salt solution or left uncoated. Colony-forming units were measured 24, 48, and 72 h after incubation and compared among the three media types and three timepoints for each strain. Differences in colony size were assessed using quantitative image analysis.Results: At early incubation, methicillin-sensitive and methicillin-resistant S. aureus and Staphylococcus epidermidis, and cephalosporin-sensitive and cephalosporin-resistant K. pneumoniae and Acinetobacter baumannii colonies were significantly smaller in the SO-coated than in the control media. The number of colony-forming units showed no significant differences between SO-coated and control media for all tested species.Conclusion: SO demonstrated an inhibitory effect on the early colony expansion of certain aerobic bacteria, including antibiotic-resistant bacterial strains, but does not have a bactericidal effect. Therefore, the use of SO tamponade should be primarily determined by the clinical presentation and intraoperative retinal findings during surgery, rather than its potential antimicrobial effects.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Outcomes after Spontaneous and Surgical Closure of Small Idiopathic Macular Holes: A Comparative Study. 特发性黄斑小孔自发闭合和手术闭合后的视觉效果：一项比较研究。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-11-27 DOI: 10.1159/000541057

Elsa Toumi, Damien Guindolet, Sophie Bonnin, Sébastien Bruneau, Marie Leflot, Amélie Duvillier, Raphaël Lejoyeux, Ramin Tadayoni

{"title":"Visual Outcomes after Spontaneous and Surgical Closure of Small Idiopathic Macular Holes: A Comparative Study.","authors":"Elsa Toumi, Damien Guindolet, Sophie Bonnin, Sébastien Bruneau, Marie Leflot, Amélie Duvillier, Raphaël Lejoyeux, Ramin Tadayoni","doi":"10.1159/000541057","DOIUrl":"10.1159/000541057","url":null,"abstract":"Introduction: Small full-thickness macular holes (FTMHs) are classically treated surgically but can also occasionally close spontaneously. Long-term visual outcomes of spontaneously closed FTMHs are not well described. We compared best-corrected visual acuity (BCVA) after surgical and spontaneous closure of idiopathic FTMH (IMHs) and assessed the effect of IMH size on BCVA.Methods: This retrospective study was performed at Rothschild Foundation Hospital, Paris, France, from January 2015 to June 2021. The study included patients with small IMH, i.e., ≤250 μm, divided into spontaneously closed IMH (SIMH) and surgically closed IMH. Both groups were divided into 3 subgroups according to IMH diameter: <100 μm, 100-150 μm, or 151-200 μm.Results: A total of 109 patients had surgical IMH closure and 18 spontaneous IMH closure. Among all the patients of the study, we observed 17% of spontaneous closure. All SIMHs were <250 μm. The groups did not differ in final BCVA or BCVA gain. BCVA significantly improved after surgery whatever the IMH size. In the SIMH group, final BCVA did not differ by IMH size. In the 100-150 μm subgroups, BCVA gain was significantly greater for the surgical closure compared to the SIMH groups (-0.35 ± 0.2 vs. -0.16 ± 0.2 logMAR; p = 0.01).Conclusion: Vision results are similar between spontaneously closed and surgically closed macular holes. Spontaneous closure of macular holes can occur; it is therefore reasonable to consider observation before macular hole surgery.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane. 用玻璃体切除术治疗特发性视网膜外膜患者视力改善的毛细血管周围和黄斑 OCTA 预测因子

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-11-25 DOI: 10.1159/000542214

Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya

{"title":"Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane.","authors":"Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya","doi":"10.1159/000542214","DOIUrl":"10.1159/000542214","url":null,"abstract":"Introduction: We investigated the changes of peripapillary and macular microvasculature in idiopathic macular epiretinal membrane (iERM) eyes before and after pars plana vitrectomy (PPV), aiming to identify potential optical coherence tomography angiography (OCTA) predictors of visual acuity improvement.Methods: Fifty-seven eyes diagnosed with iERM were enrolled and underwent PPV with ERM and internal limiting membrane (ILM) peeling. Data were collected before surgery and during the 12-month postoperative period. OCTA analysis focused on radial peripapillary capillary (RPC) vessel density (VD), superficial and deep capillary plexus (SCP and DCP, respectively). Functional and OCT structural outcomes, including best-corrected visual acuity (BCVA) and macular thickness, were also recorded.Results: Multivariate linear regression analysis revealed that higher preoperative RPC VD, lower SCP VD, and lower BCVA were predictors of postoperative BCVA improvement (p < 0.001, p = 0.047, and p < 0.001, respectively). Throughout the follow-up period, there was an observed increase in intradisc RPC VD, whole-disc VD, and parafoveal DCP VD (all p < 0.001). BCVA and central macular thickness demonstrated significant improvement (p < 0.001) within the first month following vitrectomy, which then stabilized from the third month onward.Conclusions: Preoperative microvascular measurements in iERM patients can forecast postoperative BCVA. OCTA findings reveal that both increased RPC density and reduced SCP density at baseline could serve as predictors of better visual outcomes after surgery. Enhanced RPC density may reflect a healthier optic nerve with greater potential for visual recovery, while a less dense SCP could indicate less iERM contraction, both contributing to more favorable postoperative visual results.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical, Functional, and Prognostic Results of Vitrectomy in Epiretinal Membranes Secondary to Retinal Vein Occlusions. 视网膜静脉闭塞继发视网膜外膜的玻璃体切除术的解剖、功能和预后效果。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-11-25 DOI: 10.1159/000542770

Yoo-Ri Chung, Adam Mainguy, Irini Chatziralli, Anissa Smaoui, Bahram Bodaghi, Michel Paques, Ramin Tadayoni, Maria Vittoria Cicinelli, Sara Touhami

{"title":"Anatomical, Functional, and Prognostic Results of Vitrectomy in Epiretinal Membranes Secondary to Retinal Vein Occlusions.","authors":"Yoo-Ri Chung, Adam Mainguy, Irini Chatziralli, Anissa Smaoui, Bahram Bodaghi, Michel Paques, Ramin Tadayoni, Maria Vittoria Cicinelli, Sara Touhami","doi":"10.1159/000542770","DOIUrl":"10.1159/000542770","url":null,"abstract":"Introduction: We investigated the anatomical and functional results of vitrectomy associated with the peeling of secondary epiretinal membranes (ERM) in patients with retinal vein occlusion (RVO) and determined the prognostic factors of surgical outcomes.Methods: This retrospective, multicenter, observational study included 50 patients with RVO who underwent vitrectomy with ERM removal between July 2012 and February 2021. Visual acuity (VA) and central macular thickness (CMT) were investigated up to 3 years. Univariate analysis identified the predictive factors associated with functional and anatomical outcomes.Results: Fifty eyes from 50 patients (62% with central RVO) were included. The mean VA of 0.9 ± 0.7 logMAR preoperatively improved to 0.5 ± 0.5 logMAR after 24 months (p = 0.01). Anatomically, the mean preoperative CMT was 501 ± 168 μm, decreasing to 348 ± 108 μm at month 24 (p = 0.008). By 36 months, VA had improved or stabilized in 90% of the eyes, whereas CMT had been reduced by at least 20% from baseline in 80% of the eyes. A lower number of intravitreal injections (IVI) were required after vitrectomy. Worse preoperative VA, absence of preoperative panretinal photocoagulation, and postoperative use of adjunctive IVI were associated with VA recovery. Higher baseline CMT and the use of preoperative dexamethasone injections were associated with an improvement in CMT.Conclusion: Vitrectomy for ERM secondary to RVO was effective in improving VA and recovering CMT for up to 3 years and reduced the number of IVIs.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy. 脉冲类固醇治疗后 Vogt-Koyanagi-Harada 病患者眼部生物标志物的早期变化

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-11-21 DOI: 10.1159/000542724

Tetsuya Muto, Shunsuke Kawaguchi, Shoichiro Kusuda, Keita Misu, Masaaki Sakamoto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu

{"title":"Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy.","authors":"Tetsuya Muto, Shunsuke Kawaguchi, Shoichiro Kusuda, Keita Misu, Masaaki Sakamoto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu","doi":"10.1159/000542724","DOIUrl":"10.1159/000542724","url":null,"abstract":"Introduction: This study aimed to identify when ocular biomarker changes occur within 1 month and which ocular biomarkers correlate with best-corrected visual acuity (BCVA) at months 1 and 6.Methods: We evaluated 33 patients with Vogt-Koyanagi-Harada disease who received pulse steroid therapy. The central anterior-chamber depth (ACD) and peripheral ACD were evaluated. We also analyzed axial length (AL), BCVA, spherical equivalent (SE), choroidal foveal thickness (CFT), and retinal foveal thickness (RFT). Patients were divided into two groups based on BCVA at months 1 and 6, and correlations with ocular biomarkers were investigated.Results: RFT and CFT were significantly reduced as early as day 1 (p < 0.001). AL gradually increased, with a significant increase observed at month 1 (p < 0.05). BCVA improved significantly along with SE reduction, with significant changes observed at week 1 (p < 0.05 and p < 0.01, respectively). Anterior-chamber biomarkers gradually increased, with significant increases at week 2 for central ACD (p < 0.05) and at month 1 for peripheral ACD (p < 0.05). The better BCVA group at month 1 significantly correlated with thicker RFT (p < 0.01), better BCVA (p < 0.05), shallower central ACD (p < 0.05), and shallower peripheral ACD (p < 0.05) at the initial visit. No correlation was observed between the better BCVA group at month 6 and ocular biomarkers at the initial visit.Conclusion: Although RFT and CFT changes are the earliest indicators, changes in the anterior-chamber structure appeared to be slow and delayed. Thicker RFT, better BCVA, shallower central ACD, and shallower peripheral ACD at the initial visit correlated with better BCVA at 1 month.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dealing with the Verteporfin Shortage: Treatment Options and Outcomes in Patients with Chronic and Non-Resolving Central Serous Chorioretinopathy. 应对维替泊芬短缺：慢性和非缓解性中央浆液性脉络膜视网膜病变患者的治疗方案和疗效。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-10-24 DOI: 10.1159/000542224

Femke M van den Tillaart, Franca Hartgers, Carel B Hoyng, Suzanne Yzer

{"title":"Dealing with the Verteporfin Shortage: Treatment Options and Outcomes in Patients with Chronic and Non-Resolving Central Serous Chorioretinopathy.","authors":"Femke M van den Tillaart, Franca Hartgers, Carel B Hoyng, Suzanne Yzer","doi":"10.1159/000542224","DOIUrl":"10.1159/000542224","url":null,"abstract":"Introduction: Half-dose photodynamic therapy (HD-PDT) with verteporfin is the mainstay treatment in central serous chorioretinopathy (CSC). Since 2021, there is a worldwide shortage of verteporfin. This called for adjustments of daily practice. Here, we provide a comprehensive evaluation of the adapted treatment methods and outcomes in patients with non-resolving and chronic CSC.Methods: In this retrospective cohort study, we compared patients referred in the year before the verteporfin shortage (group 1), with patients referred in the first year of verteporfin shortage (group 2). Treatment strategies, subretinal fluid (SRF) resolution, and visual acuity (VA) were evaluated during a follow-up period of at least 4 months.Results: Eighty-five eyes of 79 patients were analyzed, 36 eyes in group 1 and 49 in group 2. The treatment strategy at the first visit shifted from HD-PDT as the most performed treatment in group 1 to a more patient-tailored approach in group 2, with a wait-and-see policy in most cases. During follow-up, HD-PDT was performed significantly less in group 2 (89% vs. 45%; p < 0.001). At a mean follow-up time of 6.2 months, SRF resolved in 61% of the eyes in group 1 and in 55% in group 2 (p = 0.821). No difference in VA was observed between the groups at follow-up (p = 0.637).Conclusion: During the shortage of verteporfin, a different treatment strategy was applied, with HD-PDT being performed less frequently. By implementing a more patient-tailored approach, the VA and the resolution rate of SRF remained similar to the year before the shortage.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of Optical Coherence Tomography Biomarkers after Peeling of Epiretinal Membranes. 剥离视网膜外膜后光学相干断层扫描生物标记物的变化

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-09-24 DOI: 10.1159/000541425

Christoph Leisser, Andreas Schlatter, Manuel Ruiss, Caroline Pilwachs, Oliver Findl

{"title":"Changes of Optical Coherence Tomography Biomarkers after Peeling of Epiretinal Membranes.","authors":"Christoph Leisser, Andreas Schlatter, Manuel Ruiss, Caroline Pilwachs, Oliver Findl","doi":"10.1159/000541425","DOIUrl":"10.1159/000541425","url":null,"abstract":"Introduction: Several optical coherence tomography (OCT) biomarkers for postsurgical success among patients with idiopathic epiretinal membranes (iERMs) undergoing pars plana vitrectomy and membrane peeling have been described in the past. The aim of this study was to examine the remission of OCT biomarkers in patients with iERM after pars plana vitrectomy with membrane peeling 3 months and 1 year after surgery.Methods: This prospective study included patients scheduled for pars plana vitrectomy with membrane peeling for iERM. The postoperative remission of presurgical OCT biomarkers was analyzed from OCTs at predefined time points (3 months, 1 year) after surgery and correlated with visual acuity.Results: Among 75 patients included, remission of pre-surgically present OCT biomarkers was observed in 87.5% of eyes with disorganization of retinal inner layers, in 82.4% with cotton ball sign, in 70.4% with intraretinal cystoid changes, in 57.1% with hyperreflective foci, in 51.2% with ectopic inner foveal layer (EIFL), and in all eyes with defects of the ellipsoid zone. Central macular thickness (CMT) showed a significant reduction after surgery (p < 0.001 and p = 0.019) and was the only significant predictor for development of distance-corrected visual acuity (DCVA) 1 year after surgery (p < 0.001).Conclusion: CMT was the only significant predictor for development of DCVA 1 year after surgery. Remission rates of most of the other OCT biomarkers were high, but did not significantly influence postsurgical DCVA.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Risk Factors for Metamorphopsia after Successful Retinal Detachment Surgery. 视网膜脱离手术成功后出现变形的发生率和风险因素。

IF 2.1 4区医学

Ophthalmologica Pub Date : 2024-06-12 DOI: 10.1159/000539430

Geoffrey Pastor, Julia Salleron, Astrid Zessler, Sarah Stoebener, Karine Angioi-Duprez, Jean-Paul Berrod, Jean-Baptiste Conart

{"title":"Prevalence and Risk Factors for Metamorphopsia after Successful Retinal Detachment Surgery.","authors":"Geoffrey Pastor, Julia Salleron, Astrid Zessler, Sarah Stoebener, Karine Angioi-Duprez, Jean-Paul Berrod, Jean-Baptiste Conart","doi":"10.1159/000539430","DOIUrl":"10.1159/000539430","url":null,"abstract":"Introduction: The aim of the study was to determine the prevalence of metamorphopsia following rhegmatogenous retinal detachment (RRD) surgery, as well as associated predictive factors.Methods: A total of 107 eyes successfully operated for RRD underwent metamorphopsia severity assessment using M-CHARTS, and foveal microstructure analysis by spectral domain optical coherence tomography, at 1 and 6 months postoperatively. Univariate and multivariate logistic regression rendered evaluation of preoperative risk factors. The correlation between metamorphopsia score and outer retinal layer (ORL) integrity was investigated and preoperative risk factors evaluated.Results: The prevalence of postoperative metamorphopsia decreased from 51.4 to 29.9% and the median metamorphopsia score significantly improved (0.5, 95% CI: 0.3; 0.9, to 0.2, 95% CI: 0; 0.5, p < 0.001) from 1 to 6 months, respectively. Preoperative macular detachment was the only predictor found (OR 11.0, 95% CI: 3.1; 39.4, p < 0.001). Metamorphopsia severity was significantly associated with outer nuclear layer thickness and the status of the ellipsoid and cone interdigitation zones. One-month M-CHARTS had 81% sensitivity and 87% specificity in predicting full metamorphopsia recovery at 6 months (0.45 cut-off score).Conclusion: The prevalence of metamorphopsia decreased in parallel to ORL restoration, thus demonstrating the etiological role of photoreceptor-level morphological changes. M-CHARTS allowed for monitoring and predicting metamorphopsia recovery after RRD.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0