Association between ectopic inner foveal layer on optical coherence tomography and postoperative quantitative metamorphopsia in patients undergoing epiretinal membrane surgery.

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmologica Pub Date : 2025-05-03 DOI:10.1159/000546248
Micol Alkabes, Andrea Muraca, Lamberto La Franca, Alessandro Rabiolo, Paolo Fogagnolo, Stefano Ranno, Filippo Frerio, Mattia Marchetti, Davide Wild, Valentina Gatti, Stefano De Cillà
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引用次数: 0

Abstract

Purpose: Epiretinal membrane (ERM) is a condition that can lead to visual impairment and meta-morphopsia. This study aimed to examine the correlation between metamorphopsia and foveal mi-crostructure before and after macular surgery in a cohort of patients with advanced ERM.

Methods: The severity of metamorphopsia was quantified using M-CHARTS, and foveal micro-structure was evaluated via two optical coherence tomography (OCT) measures: central foveal thickness (CFT) and ectopic inner foveal layer (EIFL). Assessments were performed pre- and post-surgery with an average follow-up of one year. Correlations between morphological and functional parameters pre- and post-surgery were explored by means of regression analysis.

Results: 60 eyes of 57 patients diagnosed with advanced ERM and surgically treated were included in the study. Our findings showed a significant correlation between postoperative metamorphopsia and both pre- (R²=0.431) and postoperative (R²=0.300) EIFL thickness. Disparities were observed in metamorphopsia scores between patients with ERM stages 3 and 4, both pre- (0.46 ± 0.31 and 0.84 ± 0.32, respectively, P<0.01) and post-surgery (0.18 ± 0.21 and 0.46 ± 0.28, respectively, P<0.01). Postoperative EIFL thickness was the only variable significantly associated with postoper-ative metamorphopsia scores according to multiple regression analysis.

Conclusion: EIFL thickness emerges as a critical determinant of postoperative metamorphopsia severity, underscoring its importance in predicting functional outcomes after ERM surgery. Although surgery improved metamorphopsia across stages, patients with more advanced ERM experienced less favorable outcomes, stressing the importance of a timely surgical intervention.

光学相干断层扫描异位内中央凹层与视网膜前膜手术患者术后定量变形的关系。
目的:视网膜前膜(ERM)是一种可导致视力障碍和后视形态缺失的疾病。本研究旨在探讨一组晚期ERM患者黄斑手术前后变形与中央凹显微结构的相关性。方法:采用m -图量化变形的严重程度,并通过中央中央凹厚度(CFT)和异位内中央凹层(EIFL)两种光学相干断层扫描(OCT)方法评估中央凹微观结构。评估在术前和术后进行,平均随访一年。通过回归分析探讨手术前后形态学和功能参数的相关性。结果:57例经手术治疗的晚期ERM患者60只眼纳入研究。我们的研究结果显示,术后变形与术前(R²=0.431)和术后(R²=0.300)EIFL厚度有显著相关性。ERM 3期和4期患者的变形评分存在差异,前评分分别为(0.46±0.31)和(0.84±0.32)。结论:EIFL厚度是ERM术后变形严重程度的关键决定因素,强调其在预测ERM手术后功能预后方面的重要性。尽管手术可以改善不同阶段的变形,但更晚期的ERM患者的预后较差,这强调了及时手术干预的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ophthalmologica
Ophthalmologica 医学-眼科学
CiteScore
5.10
自引率
3.80%
发文量
39
审稿时长
3 months
期刊介绍: Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.
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