英国-以色列基于算法的老年性黄斑变性管理项目:用于真实世界数据管理和分析的深度学习集成。

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmologica Pub Date : 2025-06-28 DOI:10.1159/000547161
Dinah Zur, David M Wright, Marganit Shahar Gonen, Reut Shor, Qing Wen, Gidi Benyamini, Moshe Havilio, Mor Ben-Nun, Shay Look, Omer Dor, Usha Chakravarthy, Anat Loewenstein, Tunde Peto
{"title":"英国-以色列基于算法的老年性黄斑变性管理项目:用于真实世界数据管理和分析的深度学习集成。","authors":"Dinah Zur, David M Wright, Marganit Shahar Gonen, Reut Shor, Qing Wen, Gidi Benyamini, Moshe Havilio, Mor Ben-Nun, Shay Look, Omer Dor, Usha Chakravarthy, Anat Loewenstein, Tunde Peto","doi":"10.1159/000547161","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To describe the development of an integrative dataset, combining clinical and optical coherence tomography (OCT) imaging data by applying a deep learning algorithm for automated, objective, and comprehensive quantification of OCT scans to two large real-world datasets of eyes with neovascular age-related macular degeneration (nAMD). We further report baseline characteristics of the study population, focusing on demographics, clinical parameters, and quantitative retinal morphological features.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 5,207 eyes of 4,265 nAMD patients treated at two centers in the UK and Israel. Longitudinal clinical data and OCT scans were. A deep learning algorithm (NOATM, Notal Ltd.) was used to quantify retinal fluid volumes and morphological features. Baseline characteristics were compared between the cohorts.</p><p><strong>Results: </strong>The dataset included 134,340 visual acuity measurements, 79,457 OCT scans, and 73,218 anti-VEGF injections. Median follow-up was 4.54 years (UK) and 3.12 years (Israel). Baseline visual acuity differed significantly between cohorts due to varying treatment criteria. Fluid distribution patterns were similar, with most eyes showing combined intraretinal and subretinal fluid. Age-related trends in fluid volumes were observed. Weak correlations were found between baseline OCT measurements and visual acuity.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of integrating large-scale clinical and imaging data for automated analysis in nAMD. The comprehensive baseline characterization provides insights into real-world presentations and lays the groundwork for enabling personalized decision-making and optimizing outcomes based on individual patient profiles and fluid distribution patterns.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-24"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The British-Israeli Project for Algorithm-Based Management of Age-related Macular Degeneration: Deep Learning Integration for Real- World Data Management and Analysis.\",\"authors\":\"Dinah Zur, David M Wright, Marganit Shahar Gonen, Reut Shor, Qing Wen, Gidi Benyamini, Moshe Havilio, Mor Ben-Nun, Shay Look, Omer Dor, Usha Chakravarthy, Anat Loewenstein, Tunde Peto\",\"doi\":\"10.1159/000547161\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To describe the development of an integrative dataset, combining clinical and optical coherence tomography (OCT) imaging data by applying a deep learning algorithm for automated, objective, and comprehensive quantification of OCT scans to two large real-world datasets of eyes with neovascular age-related macular degeneration (nAMD). We further report baseline characteristics of the study population, focusing on demographics, clinical parameters, and quantitative retinal morphological features.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 5,207 eyes of 4,265 nAMD patients treated at two centers in the UK and Israel. Longitudinal clinical data and OCT scans were. A deep learning algorithm (NOATM, Notal Ltd.) was used to quantify retinal fluid volumes and morphological features. Baseline characteristics were compared between the cohorts.</p><p><strong>Results: </strong>The dataset included 134,340 visual acuity measurements, 79,457 OCT scans, and 73,218 anti-VEGF injections. Median follow-up was 4.54 years (UK) and 3.12 years (Israel). Baseline visual acuity differed significantly between cohorts due to varying treatment criteria. Fluid distribution patterns were similar, with most eyes showing combined intraretinal and subretinal fluid. Age-related trends in fluid volumes were observed. Weak correlations were found between baseline OCT measurements and visual acuity.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of integrating large-scale clinical and imaging data for automated analysis in nAMD. The comprehensive baseline characterization provides insights into real-world presentations and lays the groundwork for enabling personalized decision-making and optimizing outcomes based on individual patient profiles and fluid distribution patterns.</p>\",\"PeriodicalId\":19595,\"journal\":{\"name\":\"Ophthalmologica\",\"volume\":\" \",\"pages\":\"1-24\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000547161\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000547161","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:描述一个综合数据集的开发,结合临床和光学相干断层扫描(OCT)成像数据,通过应用深度学习算法对两个大型真实世界的眼睛新生血管性年龄相关性黄斑变性(nAMD)数据集进行自动化、客观和全面的OCT扫描量化。我们进一步报告了研究人群的基线特征,重点是人口统计学、临床参数和定量视网膜形态学特征。方法:本回顾性研究分析了在英国和以色列两个中心治疗的4265名nAMD患者的5207只眼睛的数据。纵向临床资料和OCT扫描。采用深度学习算法(NOATM, Notal Ltd.)量化视网膜液体积和形态特征。比较各组之间的基线特征。结果:数据集包括134,340次视力测量,79,457次OCT扫描和73,218次抗vegf注射。中位随访时间为4.54年(英国)和3.12年(以色列)。由于不同的治疗标准,各组之间的基线视力差异显著。液体分布模式相似,大多数眼睛显示视网膜内和视网膜下混合液体。观察到与年龄相关的液体体积趋势。基线OCT测量值与视力之间存在弱相关性。结论:本研究证明了整合大规模临床和影像学数据进行nAMD自动分析的可行性。全面的基线特征提供了对现实世界的见解,并为实现个性化决策和基于个体患者概况和流体分布模式优化结果奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The British-Israeli Project for Algorithm-Based Management of Age-related Macular Degeneration: Deep Learning Integration for Real- World Data Management and Analysis.

Purpose: To describe the development of an integrative dataset, combining clinical and optical coherence tomography (OCT) imaging data by applying a deep learning algorithm for automated, objective, and comprehensive quantification of OCT scans to two large real-world datasets of eyes with neovascular age-related macular degeneration (nAMD). We further report baseline characteristics of the study population, focusing on demographics, clinical parameters, and quantitative retinal morphological features.

Methods: This retrospective study analyzed data from 5,207 eyes of 4,265 nAMD patients treated at two centers in the UK and Israel. Longitudinal clinical data and OCT scans were. A deep learning algorithm (NOATM, Notal Ltd.) was used to quantify retinal fluid volumes and morphological features. Baseline characteristics were compared between the cohorts.

Results: The dataset included 134,340 visual acuity measurements, 79,457 OCT scans, and 73,218 anti-VEGF injections. Median follow-up was 4.54 years (UK) and 3.12 years (Israel). Baseline visual acuity differed significantly between cohorts due to varying treatment criteria. Fluid distribution patterns were similar, with most eyes showing combined intraretinal and subretinal fluid. Age-related trends in fluid volumes were observed. Weak correlations were found between baseline OCT measurements and visual acuity.

Conclusions: This study demonstrates the feasibility of integrating large-scale clinical and imaging data for automated analysis in nAMD. The comprehensive baseline characterization provides insights into real-world presentations and lays the groundwork for enabling personalized decision-making and optimizing outcomes based on individual patient profiles and fluid distribution patterns.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ophthalmologica
Ophthalmologica 医学-眼科学
CiteScore
5.10
自引率
3.80%
发文量
39
审稿时长
3 months
期刊介绍: Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信