Ophthalmologica最新文献_第10页

Front & Back Matter 正面和背面

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-11-01 DOI: 10.1159/000528087

A. Cruess, S. Fauser, A. Gaudric, F. Holz

引用次数: 0

Mediastinal Abscess Formation after EUS-Guided Sampling in a Young Patient with Sarcoidosis: Be Aware of the Increased Risk! 年轻结节病患者eus引导取样后纵隔脓肿形成:注意风险增加!

IF 0.9 4区医学

Ophthalmologica Pub Date : 2022-10-20 eCollection Date: 2023-11-01 DOI: 10.1159/000526508

Miguel Bispo, Susana Marques, Sara Teles de Campos, Ricardo Rio-Tinto, Paulo Fidalgo, Jacques Devière

引用次数: 0

Front & Back Matter 正面和背面事项

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-08-01 DOI: 10.1159/000526289

引用次数: 0

Iron nitrosyl complexes are formed from nitrite in the human placenta. 亚硝酸铁在人体胎盘中形成亚硝基络合物。

4区医学

Ophthalmologica Pub Date : 2022-07-01 Epub Date: 2022-05-26 DOI: 10.1016/j.jbc.2022.102078

George T Mukosera, Patricia Principe, Eugenia Mata-Greenwood, Taiming Liu, Hobe Schroeder, Mana Parast, Arlin B Blood

{"title":"Iron nitrosyl complexes are formed from nitrite in the human placenta.","authors":"George T Mukosera, Patricia Principe, Eugenia Mata-Greenwood, Taiming Liu, Hobe Schroeder, Mana Parast, Arlin B Blood","doi":"10.1016/j.jbc.2022.102078","DOIUrl":"10.1016/j.jbc.2022.102078","url":null,"abstract":"Placental nitric oxide (NO) is critical for maintaining perfusion in the maternal-fetal-placental circulation during normal pregnancy. NO and its many metabolites are also increased in pregnancies complicated by maternal inflammation such as preeclampsia, fetal growth restriction, gestational diabetes, and bacterial infection. However, it is unclear how increased levels of NO or its metabolites affect placental function or how the placenta deals with excessive levels of NO or its metabolites. Since there is uncertainty over the direction of change in plasma levels of NO metabolites in preeclampsia, we measured the levels of these metabolites at the placental tissue level. We found that NO metabolites are increased in placentas from patients with preeclampsia compared to healthy controls. We also discovered by ozone-based chemiluminescence and electron paramagnetic resonance that nitrite is efficiently converted into iron nitrosyl complexes (FeNOs) within the human placenta and also observed the existence of endogenous FeNOs within placentas from sheep and rats. We show these nitrite-derived FeNOs are relatively short-lived, predominantly protein-bound, heme-FeNOs. The efficient formation of FeNOs from nitrite in the human placenta hints toward the importance of both nitrite and FeNOs in placental physiology or pathology. As iron nitrosylation is an important posttranslational modification that affects the activity of multiple iron-containing proteins such as those in the electron transport chain, or those involved in epigenetic regulation, we conclude that FeNOs merit increased study in pregnancy complications.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"203 1","pages":"102078"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86415358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysing Subgroups and Treatment Discontinuation in a Finnish Cohort of Patients with Neovascular AMD 分析芬兰新生血管性AMD患者的亚组和停药情况

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-05-25 DOI: 10.1159/000524848

Terhi Ollila, Juuso Silvennoinen, Ashwini R Joshi, Jia Liu, S. Kulathinal, I. Immonen

{"title":"Analysing Subgroups and Treatment Discontinuation in a Finnish Cohort of Patients with Neovascular AMD","authors":"Terhi Ollila, Juuso Silvennoinen, Ashwini R Joshi, Jia Liu, S. Kulathinal, I. Immonen","doi":"10.1159/000524848","DOIUrl":"https://doi.org/10.1159/000524848","url":null,"abstract":"Purpose: We aimed to study the regional detailed visual outcome and treatment discontinuation of neovascular age-related macular degeneration (nAMD). Methods: Clinical records of 110 patients treated for nAMD at the sole referral centre in the Helsinki region were analysed retrospectively. The follow-up was up to the fourth year. Results: The mean visual acuity (VA) at baseline was 56.3 (SD 16.2) letters. The mean last VA at the first year was 59.7 (20.2), and the corresponding values for the second, third, and fourth years were 60.8 (20.6), 60.0 (19.0), and 59.7 (19.3). The mean difference from baseline was +3.39 (SD 14.6), +3.59 (17.6), +0.08 (18.9), and +3.08 (14.3). The number of patients declined each year, with only 51% of the patients being in treatment until the fourth year. The patients with shorter duration of follow-up tended to have a lower baseline VA, lesser gains, and an earlier decline in VA. The VA levels at the last visit were poorer in the shorter follow group. The initial VA response predicted later VA, whereas VA at baseline, age, or sex had no effect. However, the effect vanished with a longer time in treatment. Conclusions: Long-term VA stabilization was obtained in a regional material. Patients with neovascular AMD consist of cohorts with varying visual outcome and treatment time. Many of the patients benefit from the treatment for some time, however. When comparing real-world results, the outcome of the different follow-up time cohorts should be considered. This calls for new methods for analysing real-world nAMD treatment results.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"245 1","pages":"358 - 367"},"PeriodicalIF":2.6,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47398839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Scleral Buckling Alone or in Combination with Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment Repair: A Meta-Analysis of 7,212 Eyes 巩膜屈曲单独或联合平板玻璃体切除术治疗孔源性视网膜脱离7212眼的Meta分析

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-05-09 DOI: 10.1159/000524888

Prem A H Nichani, Arjan S. Dhoot, M. Popovic, Arshia Eshtiaghi, Andrew Mihalache, Aman P. Sayal, Hannah J. Yu, C. Wykoff, P. Kertes, Rajeev H. Muni

{"title":"Scleral Buckling Alone or in Combination with Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment Repair: A Meta-Analysis of 7,212 Eyes","authors":"Prem A H Nichani, Arjan S. Dhoot, M. Popovic, Arshia Eshtiaghi, Andrew Mihalache, Aman P. Sayal, Hannah J. Yu, C. Wykoff, P. Kertes, Rajeev H. Muni","doi":"10.1159/000524888","DOIUrl":"https://doi.org/10.1159/000524888","url":null,"abstract":"Purpose: The efficacy and safety of scleral buckling (SB) versus combination SB and pars plana vitrectomy (SB + PPV) for rhegmatogenous retinal detachment (RRD) repair remains unclear. Methods: A systematic review and meta-analysis was conducted to identify comparative studies published from Jan 2000–Jun 2021 that reported on the efficacy and/or safety following SB and SB + PPV for RRD repair. Final best-corrected visual acuity (BCVA) represented the primary endpoint, while reattachment rates and ocular adverse events were secondary endpoints. A random-effects meta-analysis was performed, and 95% confidence intervals were calculated. Results: Across 18 studies, 3912 SB and 3300 SB + PPV eyes were included. Final BCVA was nonsignificantly different between SB and SB + PPV (20/38 vs. 20/66 Snellen; WMD = −0.11 LogMAR; 95% CI: [–0.29, 0.07]; p = 0.23). Primary reattachment rate was similar between procedures (p = 0.74); however, SB alone achieved a significantly higher final reattachment rate (97.40% vs. 93.86%; RR = 1.03; 95% CI: [1.00, 1.06]; p = 0.04). Compared to SB + PPV, SB alone had a significantly lower risk of postoperative macular edema (RR = 0.69; 95% CI: [0.47, 1.00]; p = 0.05) and cataract formation (RR = 0.34; 95% CI: [0.12, 0.96]; p = 0.04). The incidence of macular hole, epiretinal membrane, residual subretinal fluid, proliferative vitreoretinopathy, elevated intraocular pressure, and extraocular muscle dysfunction were similar between SB and SB + PPV. Conclusions: There was no significant difference in final BCVA between SB + PPV and SB alone in RRD. SB alone offers a slightly higher final reattachment rate along with a reduced risk of macular edema and cataract. Primary reattachment rate and the incidence of other complications were similar between the two procedures.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"245 1","pages":"296 - 314"},"PeriodicalIF":2.6,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47603827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Front & Back Matter 正面和背面事项

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-05-01 DOI: 10.1159/000524834

J. Jonas

引用次数: 0

The Therapeutic Conversation and a Holistic Approach to the Management of Patients with Neovascular Age-Related Macular Degeneration 新生血管性年龄相关性黄斑变性患者的治疗对话和整体治疗方法

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-04-27 DOI: 10.1159/000524761

P. Cackett, S. Young

{"title":"The Therapeutic Conversation and a Holistic Approach to the Management of Patients with Neovascular Age-Related Macular Degeneration","authors":"P. Cackett, S. Young","doi":"10.1159/000524761","DOIUrl":"https://doi.org/10.1159/000524761","url":null,"abstract":"In the recent paper by Zvi et al. in Ophthalmologica, they demonstrate that reassuringly in the management of patients with neovascular age-related macular degeneration, virtual evaluation results in similar treatment decisions compared to standard face-to-face clinical examination. However, we would caution against the exclusive use of virtual clinics to manage macula clinics but rather intersperse virtual clinic appointments with regular face to face assessments. Many macula patients who are often experiencing progressive visual loss derive benefit from a face to face \"therapeutic conversation\". Furthermore, there are many patients with end-stage macular disease who may not require or do not want to continue with ongoing anti-VEGF treatment, but as a result of repeated virtual assessments, they remain on unnecessary repeat clinic appointments, adding to the existing issues with capacity. In order to address this, we introduced a multidisciplinary face to face macular clinic at our tertiary referral centre as a one-stop consultation for patients with advanced macular disease who are deemed to no longer benefit from further treatment or follow-up or have intimated to a member of staff that they are no longer keen on further treatment. We would recommend that this holistic multidisciplinary clinic which we have described is the best way of managing end-stage macula patients.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"245 1","pages":"393 - 394"},"PeriodicalIF":2.6,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43859478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epiretinal Membrane in Patients with Diabetic Macular Edema 糖尿病性黄斑水肿患者的视网膜前膜

IF 2.6 4区医学

Ophthalmologica Pub Date : 2022-04-27 DOI: 10.1159/000524742

Gilad Rabina, A. Hilely, D. Barequet, Shai Cohen, Naama Lipin, M. Mimouni, Adina R. Glick, A. Barak, A. Loewenstein, Shulamit Schwartz

{"title":"Epiretinal Membrane in Patients with Diabetic Macular Edema","authors":"Gilad Rabina, A. Hilely, D. Barequet, Shai Cohen, Naama Lipin, M. Mimouni, Adina R. Glick, A. Barak, A. Loewenstein, Shulamit Schwartz","doi":"10.1159/000524742","DOIUrl":"https://doi.org/10.1159/000524742","url":null,"abstract":"Purpose: The aim of the study was to compare anatomical and functional outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetes retinopathy patients with and without diabetic macular edema (DME). Methods: A retrospective interventional case series of consecutive patients who underwent PPV with ERM peeling. Patients were divided into two groups: those with and without preoperative DME. Visual acuity (VA) and optical coherence tomography parameters were evaluated before surgery and during 12 months of follow-up. Results: A total of 354 patients underwent PPV with ERM peeling, of which 51 met the inclusion criteria. Twenty-three were diagnosed with DME and were younger (66.3 ± 9.6 vs. 73.1 ± 8.2 years, p = 0.001), had longer diabetes mellitus (DM) duration (18.9 ± 7.1 vs. 14.3 ± 10.9 years, p = 0.04) and higher HbA1C% (7.6 ± 1.4 vs. 7.1 ± 1.3, p = 0.04). VA improved from 20/105 to 20/60 Snellen (p = 0.004) and central macular thickness decreased from 469.3 ± 64.9 μm to 331.1 ± 92.2 μm (p < 0.001) in the DME group and from 20/87 to 20/44 Snellen (p < 0.001) and from 463.1 ± 53.5 μm to 341.3 ± 49.5 μm (p = 0.01) in the non-DME group. Yearly intravitreal injection rate decreased from 5.9 ± 2.5 to 2.9 ± 3.0 (p < 0.001) injections in the DME group. Conclusions: DME patients with ERM experience significant improvement in VA, macular thickness, and yearly intravitreal injections after PPV with ERM peeling. DME patients are younger, with longer duration of DM and higher HbA1C% levels at presentation in comparison to diabetic ERM patients without DME.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"245 1","pages":"446 - 454"},"PeriodicalIF":2.6,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45638158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day. 经皮耳廓迷走神经刺激对人类大脑功能网络的改变：时间的影响

IF 2.7 4区医学

Ophthalmologica Pub Date : 2022-04-26 DOI: 10.3390/brainsci12050546

Randi von Wrede, Timo Bröhl, Thorsten Rings, Jan Pukropski, Christoph Helmstaedter, Klaus Lehnertz

{"title":"Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day.","authors":"Randi von Wrede, Timo Bröhl, Thorsten Rings, Jan Pukropski, Christoph Helmstaedter, Klaus Lehnertz","doi":"10.3390/brainsci12050546","DOIUrl":"10.3390/brainsci12050546","url":null,"abstract":"Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive treatment option for different diseases and symptoms, such as epilepsy or depression. Its mechanism of action, however, is still not fully understood. We investigated short-term taVNS-induced changes of local and global properties of EEG-derived, evolving functional brain networks from eighteen subjects who underwent two 1 h stimulation phases (morning and afternoon) during continuous EEG-recording. In the majority of subjects, taVNS induced measurable modifications of network properties. Network alterations induced by stimulation in the afternoon were clearly more pronounced than those induced by stimulation in the morning. Alterations mostly affected the networks' topology and stability properties. On the local network scale, no clear-cut spatial stimulation-related patterns could be discerned. Our findings indicate that the possible impact of diurnal influences on taVNS-induced network modifications would need to be considered for future research and clinical studies of this non-pharmaceutical intervention approach.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"220 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86602074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0