Changes of Optical Coherence Tomography Biomarkers after Peeling of Epiretinal Membranes.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2024-09-24 DOI:10.1159/000541425

Christoph Leisser, Andreas Schlatter, Manuel Ruiss, Caroline Pilwachs, Oliver Findl

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引用次数: 0

Abstract

Introduction: Several optical coherence tomography (OCT) biomarkers for postsurgical success among patients with idiopathic epiretinal membranes (iERMs) undergoing pars plana vitrectomy and membrane peeling have been described in the past. The aim of this study was to examine the remission of OCT biomarkers in patients with iERM after pars plana vitrectomy with membrane peeling 3 months and 1 year after surgery.

Methods: This prospective study included patients scheduled for pars plana vitrectomy with membrane peeling for iERM. The postoperative remission of presurgical OCT biomarkers was analyzed from OCTs at predefined time points (3 months, 1 year) after surgery and correlated with visual acuity.

Results: Among 75 patients included, remission of pre-surgically present OCT biomarkers was observed in 87.5% of eyes with disorganization of retinal inner layers, in 82.4% with cotton ball sign, in 70.4% with intraretinal cystoid changes, in 57.1% with hyperreflective foci, in 51.2% with ectopic inner foveal layer (EIFL), and in all eyes with defects of the ellipsoid zone. Central macular thickness (CMT) showed a significant reduction after surgery (p < 0.001 and p = 0.019) and was the only significant predictor for development of distance-corrected visual acuity (DCVA) 1 year after surgery (p < 0.001).

Conclusion: CMT was the only significant predictor for development of DCVA 1 year after surgery. Remission rates of most of the other OCT biomarkers were high, but did not significantly influence postsurgical DCVA.

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剥离视网膜外膜后光学相干断层扫描生物标记物的变化

导言：过去曾描述过特发性视网膜外膜（iERM）患者接受玻璃体旁切除术和视网膜膜剥离术后成功的几种光学相干断层扫描（OCT）生物标志物。本研究的目的是检测特发性视网膜外膜（iERM）患者在接受玻璃体旁切除术和膜剥离术后三个月和一年的 OCT 生物标志物的缓解情况：这项前瞻性研究纳入了因iERM而计划行膜剥离玻璃体旁切除术的患者。根据术后预定时间点（三个月、一年）的 OCT 分析术前 OCT 生物标志物的术后缓解情况，并将其与视力相关联：结果：在纳入的 75 名患者中，87.5% 的视网膜内层紊乱 (DRIL) 眼、82.4% 的棉球征眼、70.4% 的视网膜内囊样变眼、57.1% 的高反射灶眼、51.2% 的异位眼窝内层 (EIFL) 眼以及所有椭圆形区缺损眼的术前 OCT 生物标志物均有所缓解。黄斑中心厚度（CMT）在术后显著降低（p<0.001 和 p=0.019），并且是术后一年距离矫正视力（DCVA）发展的唯一显著预测因子（p<0.001）：结论：CMT 是术后一年远距离矫正视力（DCVA）发展的唯一重要预测因素。结论：CMT 是唯一能显著预测术后一年远距离矫正视力发展的指标，其他大多数 OCT 生物标志物的缓解率都很高，但对术后远距离矫正视力的影响不大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.