Ophthalmologica最新文献

{"title":"Weekend Effect on Vitrectomy: Insights from a Nationwide Population-Based Study in Korea.","authors":"Min Seok Kim, Eunjeong Ji","doi":"10.1159/000552822","DOIUrl":"10.1159/000552822","url":null,"abstract":"<p><strong>Introduction: </strong>This study compared the reoperation rate of vitrectomy between weekend/holiday and weekday surgeries.</p><p><strong>Methods: </strong>This nationwide, population-based retrospective cohort study used the Korean Health Insurance Review and Assessment Service database to identify 387,544 adults (≥18 years) who underwent initial vitrectomy between January 2011 and March 2024. Weekend/holiday and weekday surgeries were compared. The risk of reoperation within 90 days was assessed using Cox proportional hazards regression, with sensitivity analyses extending the outcome to 180 days and subgroup analyses of the five most common diagnoses. Logistic regression was performed as a secondary analysis.</p><p><strong>Results: </strong>A total of 45,074 patients underwent vitrectomy on weekends/holidays and 342,470 on weekdays. Reoperation rates per 100 person-months were 2.83 in the weekend/holiday group and 2.87 in the weekday group. Weekend/holiday surgery was not associated with reoperation within 90 days (adjusted hazard ratio [aHR], 1.00; 95% confidence interval [CI]: 0.97-1.04; p = 0.860) or 180 days (aHR, 1.02; 95% CI: 0.99-1.04; p = 0.274). Logistic regression showed consistent results for both 90 days (adjusted odds ratio [aOR], 1.00; 95% CI: 0.97-1.04; p = 0.849) and 180 days (aOR, 1.02; 95% CI: 0.99-1.05; p = 0.283). Subgroup analyses revealed no association between weekend/holiday surgery and reoperation across diagnostic categories, except for vitreous hemorrhage, in which a higher risk of reoperation was observed within 180 days (aHR, 1.09; 95% CI: 1.02-1.16; p = 0.011; aOR, 1.10; 95% CI: 1.02-1.18; p = 0.009).</p><p><strong>Conclusion: </strong>Our analysis of nationwide claims data from Korea demonstrated that vitrectomy surgery is not subject to a weekend effect, either overall or within major diagnostic subgroups.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Royal College of Ophthalmologists National Ophthalmology Database Age-Related Macular Degeneration Audit, Report 2: Baseline Characteristics, the Care Pathway and 12-Month Visual Acuity and Safety Outcomes for 54,882 Eyes Starting Treatment for Neovascular Age-Related Macular Degeneration.","authors":"Marta H Gruszka-Goh, Paul H J Donachie, Ramandeep Romi Chhabra, Martin McKibbin","doi":"10.1159/000552289","DOIUrl":"10.1159/000552289","url":null,"abstract":"<p><strong>Introduction: </strong>Real-world datasets typically involve diverse patient populations and provide valuable insights into how therapies work in routine clinical practice. This study reports aggregate data from the United Kingdom age-related macular degeneration (AMD) Audit, focussing on baseline characteristics, treatment and 1-year acuity and safety outcomes for eyes starting treatment for neovascular AMD between April 2021 and March 2023.</p><p><strong>Methods: </strong>Anonymised demographic and clinical data, collected as part of routine clinical care, were extracted from electronic medical records at participating centres providing NHS-funded treatment. Analyses were restricted to eyes with baseline visual acuity recorded at treatment initiation.</p><p><strong>Results: </strong>Analysis included 54,882 eyes of 48,371 patients from 78 participating treatment centres. Just over 60% were female and the median age at the start of treatment was 79.9 years for first treated eyes and 82.2 years for second treated eyes. Median baseline acuity was 60 ETDRS letters (interquartile range (IQR) = 44-70) and 28.1% of eyes had \"good\" acuity, defined as ≥70 ETDRS letters. The initial three injections, during the loading phase of monthly treatment, were given within 10 weeks in 64% of eyes and the median number of injections in the first 12 months was 6 (IQR 4-8). The median interval between injections at the end of the first year of treatment was 8 weeks (IQR 6-12 weeks). Trained non-medical healthcare professionals administered at least 72% of injections. Median acuity after 12 months was 65 ETDRS letters (IQR 48-75) and 43.1% had \"good\" visual acuity. The incidence of intra-ocular inflammation and presumed infectious endophthalmitis after each injection were 0.03% (1 in 3,176) and 0.014% (1 in 7,013) respectively. There was no difference in the incidence of either complication by profession of the injector.</p><p><strong>Conclusion: </strong>Aggregate data from the UK AMD Audit provides real-world evidence and a benchmark against which other countries and centres can compare local performance and outcomes. Almost 91% of eyes retained stable acuity and avoided moderate visual loss after 12 months of treatment. The best acuity outcomes were obtained in younger patients and in eyes treated second, with good baseline acuity, prompt completion of the loading phase of treatment and receiving more injections during the first 12 months of treatment.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Customized Vitreous Substitute: Swelling Behavior, Enzymatic Degradation, and Cellular Adhesion of a Hyaluronic Acid-Based Hydrogel.","authors":"Michelle Mueller, Dalya Yapar, Katja Lemmer, Rudolph Tobias Linn, Peter Szurman","doi":"10.1159/000551941","DOIUrl":"10.1159/000551941","url":null,"abstract":"<p><strong>Introduction: </strong>Hyaluronic acid (HA)-based hydrogels are promising vitreous substitutes, but clinical translation requires more than biocompatibility alone. Key determinants such as intraocular swelling, enzymatic stability, and cellular interactions must be precisely controlled. This study investigated strategies to further refine an advanced HA hydrogel toward these requirements.</p><p><strong>Methods: </strong>UV-crosslinked HA hydrogels were tested as chunks and injectable extrudates under varying osmolarities. Swelling behavior was analyzed in physiological media, including a dehydration-rehydration protocol. Enzymatic degradation assays with hyaluronidase, trypsin, and collagenase were performed, and fibroblast adhesion/proliferation was evaluated in the context of proliferative vitreoretinopathy.</p><p><strong>Results: </strong>Swelling was formulation- and format-dependent, with pre-dehydrated extrudates reaching up to 1.8-fold baseline weight. Only hyaluronidase induced degradation, while proteases had no effect. Fibroblasts showed reduced proliferation on the hydrogel surface.</p><p><strong>Conclusion: </strong>Systematic tuning of swelling, enzymatic stability, and antifibrotic properties advances HA hydrogels toward clinical application as customizable vitreous substitutes.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"395-406"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' Perspectives on Climate Change, Health, and Sustainability in Ophthalmology.","authors":"Denise Yang-Seeger, Annkathrin Schellstede, Laurenz J B Pauleikhoff, Martin S Spitzer, Johannes Birtel","doi":"10.1159/000549175","DOIUrl":"10.1159/000549175","url":null,"abstract":"<p><p><p>Introduction: Sustainability is becoming increasingly important in ophthalmology due to growing environmental, economic, and social responsibilities. Integrating sustainability into clinical practice requires not only advocacy by clinicians but also patients' collaboration and awareness. This study aimed to understand patients' perspectives on sustainability and the role attributed to ophthalmologists.</p><p><strong>Methods: </strong>In this multi-item survey, ophthalmologic patients were assessed regarding their views on sustainability in general and in ophthalmology in particular. Levels of agreement were measured using a Likert scale.</p><p><strong>Results: </strong>In total, 105 patients were included. There was high agreement on statements that anthropogenic climate change is an urgent issue, requires action, and is impacting population health (all, ≥85%). Patients supported advocacy of ophthalmologists for more sustainability, and there was broad agreement (74%) that ophthalmology practices should become more environmentally sustainable. No clear trend was observed whether the healthcare sector is taking sufficient measures to become more sustainable and whether the carbon footprint of ophthalmology is smaller compared to other specialties (44% and 33% disagreed; 41% and 63% [strongly] agreed, respectively). Patients aged ≥70 years agreed significantly more than younger patients that healthcare plays an important role in fighting climate change. A similar trend was observed for female compared to male patients. Female and older patients also tended to express greater expectations for ophthalmologists to advocate for sustainability, along with a call for increased advocacy from legislators and ophthalmology societies.</p><p><strong>Conclusion: </strong>Patients showed strong awareness of anthropogenic climate change and the need for ophthalmology to become more sustainable. Especially female and older patients tended to expect more advocacy from ophthalmologists, ophthalmological societies, and the legislators. </p>.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1-7"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time Effect on Silicone Oil Emulsion Formed in a Model of the Eye Vitreous Chamber.","authors":"Michela Elena Pedretti, Eva Santini, Francesca Ravera, Mariantonia Ferrara, Libero Liggieri, Irene Nepita, Mario R Romano, Rodolfo Repetto","doi":"10.1159/000550198","DOIUrl":"10.1159/000550198","url":null,"abstract":"<p><strong>Introduction: </strong>Silicone oil (SO) is widely used as a long-term intraocular tamponade following pars plana vitrectomy (PPV) for complex retinal conditions. However, its emulsification is associated with serious complications, including intraocular inflammation and glaucoma. While various factors influencing this process have been explored, the role of time in SO emulsification remains unclear. This study investigates the movement time effect on SO emulsification using a physiologically realistic model, with a focus on changes in droplet size distribution and emulsion density.</p><p><strong>Methods: </strong>A 3D-printed, anatomically accurate model of the human vitreous chamber was filled with SO and an albumin-containing aqueous phase, maintained at 35°C. Experiments were conducted with varying albumin concentrations and saccadic eye movements of different amplitudes. Emulsions were sampled and analyzed after 6 h, 12 h, 24 h, and 6 days.</p><p><strong>Results: </strong>Emulsification was observed under all conditions. Over time, the number of smaller droplets increased, and emulsion density rose sharply within the first 12 h, followed by a slower progression. Higher albumin levels and larger saccadic amplitudes promoted more extensive emulsification.</p><p><strong>Conclusion: </strong>These findings identify the early postoperative period, particularly the first 12 h, as critical for SO emulsification.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"219-229"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of the EyeArt Artificial Intelligence System for Diabetic Retinopathy: A Systematic Review and Meta-Analysis.","authors":"Isabel Inmaculada Guedes Guedes, Pedro Saavedra Santana, Ángel Ramos de Miguel, Ángel Ramos Macías, Francisco Cabrera López, Ayoze González Hernández","doi":"10.1159/000550443","DOIUrl":"10.1159/000550443","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy (DR) persists as a predominant cause of preventable vision loss globally, with its prevalence escalating in conjunction with the diabetes epidemic. Efficient, automated screening is needed to enable earlier detection of DR at scale. Artificial intelligence-driven platforms, such as EyeArt® (Eyenuk Inc.), offer a scalable solution with potential to alleviate the burden on healthcare systems.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA and MOOSE guidelines. This review was prospectively registered in PROSPERO (CRD42024571137). Observational studies published between 2016 and 2024 assessing the diagnostic performance of the EyeArt® system for DR detection were retrieved from PubMed, Scopus, and Embase. Data on sensitivity, specificity, and diagnostic odds ratio (DOR) were extracted, and pooled estimates were calculated using a random-effects model. Study quality was assessed using QUADAS-2 and GRADE frameworks.</p><p><strong>Results: </strong>Seventeen studies, met the inclusion criteria. The pooled log DOR was 3.96 (95% CI: 3.54-4.39), and the area under the summary receiver operating characteristic curve was 0.932 (95% CI: 0.885-0.985), indicating high overall diagnostic accuracy. No significant heterogeneity was observed in the pooled diagnostic OR, although sensitivity and specificity varied across studies.</p><p><strong>Conclusions: </strong>EyeArt® demonstrates high diagnostic accuracy for detecting any-grade and referable DR across diverse clinical and geographical settings. Its integration into DR screening programs could improve early detection, optimize healthcare resource allocation, and expand access to ophthalmic care, particularly in resource-limited environments.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"126-144"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Evolution and Growth Rate Assessment of Non-Exudative Macular Neovascularization: A Multicenter Analysis.","authors":"Emilia Maggio, Filippo Avogaro, Lorenzo Casillo, Maurizio Mete, Enzo Maria Vingolo, Giorgia Maraone, Lorenza Sanfilippo, Massimo Guerriero, Grazia Pertile","doi":"10.1159/000551308","DOIUrl":"10.1159/000551308","url":null,"abstract":"<p><strong>Introduction: </strong>Non-exudative macular neovascularization (neMNV) in age-related macular degeneration (AMD) may remain stable or progress to exudation with vision loss, but its natural history is not well established. This study aimed to assess the prevalence of neMNV, the conversion rate to exudation, and to discern differences between neMNVs that exhibited exudation versus those that remained non-exudative.</p><p><strong>Methods: </strong>In this retrospective, multicentric, longitudinal study, consecutive patients treated with anti-VEGF between august 2008 and June 2023, presenting exudative AMD in one eye and intermediate AMD in the fellow eye, were analyzed. The presence of neMNVs in the fellow eyes and their conversion rate to exudation were assessed. Clinical and anatomical features were compared between eyes that developed exudation versus those that did not. The correlation between lesion major diameters and areas was examined to evaluate their equivalence as parameters for assessing neMNV growth rate.</p><p><strong>Results: </strong>A total of 61 eyes out of 840 (7.3%) exhibited neMNV. Of these, 21 neMNV (34.42%) converted to exudation in a mean time of 24.14 months (min. 7 - max. 113). The remaining 40 eyes did not develop exudation during a mean follow-up of 32.5 months (min. 12 - max. 101). No significant differences were found regarding visual acuity, OCT angiography features, or baseline lesion diameters. NeMNV that developed exudation exhibited a higher lesion growth rate (p value <0.001). The growth rate evaluated using lesion major diameters was consistent with that obtained through lesion area measurements.</p><p><strong>Conclusion: </strong>The results highlight lesion growth rate as a marker of conversion risk. Lesion diameter was identified as a reliable parameter for monitoring neMNV progression. Even considering a long-term follow-up, many lesions did not develop exudation. These results support the idea that neMNV may represent a spectrum of neovascularizations with different characteristics and clinical courses.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"238-248"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000550887","DOIUrl":"10.1159/000550887","url":null,"abstract":"<p><p>In the article by Özdek et al. entitled \"Clinical and Demographic Characteristics of Treatment Requiring Retinopathy of Prematurity in Big Premature Infants in Turkiye: Report No. 1 (BIG-ROP Study)\" [Ophthalmologica. 2024;247:293-303; https://doi.org/10.1159/000541053], there is an error in the name of Dr. Özlem Bozkurt, listed as part of the BIG-ROP Study Group, which has incorrectly been published as Dr. Özlem Bozkurt Demiroğlu.The original article has been corrected to reflect this change.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"212"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chorioretinal Atrophy after Voretigene Neparvovec Therapy in <italic>RPE65</italic> Mutation-Associated Inherited Retinal Disease: Longitudinal Characterization in Multimodal Imaging.","authors":"Sandrine H Sassen, Marlene Sassmannshausen, Josua Sassen, Markus N Preising, Johanna P Scholz, Frank G Holz, Birgit Lorenz, Philipp Herrmann","doi":"10.1159/000549548","DOIUrl":"10.1159/000549548","url":null,"abstract":"<p><p><p>Introduction: The detection of chorioretinal atrophy (CRA) following voretigene neparvovec (VN) therapy for RPE65-IRD highlights the need for long-term monitoring to better understand the safety and efficacy of this gene augmentation treatment. This study aimed to longitudinally assess the development of VN-associated CRA, its presentation in multimodal retinal imaging, and potential implications on visual function in patients with RPE65-IRD.</p><p><strong>Methods: </strong>This single-center, prospective cohort study was conducted at the University of Bonn. A total of 21 patients with confirmed RPE65-IRD underwent subretinal VN therapy. Multimodal imaging, including blue-light fundus autofluorescence (BAF), near-infrared imaging (IR), near-infrared fundus autofluorescence (IRAF), and color fundus photography (CFP), assessed atrophy development. The primary outcome measure was the incidence and size of CRA, while secondary outcomes included the relationship between CRA and changes in visual function.</p><p><strong>Results: </strong>The study reported a 50% (16/32 eyes) incidence of CRA, with lesions primarily located in the macula (86.7%), bleb area (86.67%), injection site (80%), and periphery (80%). Lesion detection and size varied between BAF, IR, IRAF, and CFP, with the largest CRA detected in BAF imaging. Initially, the median enlargement rate of CRA was 60.50 mm2/year (131.20). Notably, eyes with CRA development had significantly better baseline low luminance visual acuity.</p><p><strong>Discussion: </strong>This study highlights the crucial role of multimodal imaging in monitoring VN-associated CRA. Differences in lesion detection and size assessment across imaging modalities were observed, with the largest CRA extent detected in BAF imaging. Median visual function remained stable. These findings emphasize the complexity of VN therapy outcomes and the need for close surveillance using combined multimodal imaging to better understand the long-term clinical implications. </p>.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"30-40"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhegmatogenous Retinal Detachment Associated with Giant Retinal Tears: The Effect of Tamponade Choice on Outcome.","authors":"Muhammad Raza Cheema, Alexander Mehta, Jonathan Smith, David Yorston, David H Steel","doi":"10.1159/000552158","DOIUrl":"10.1159/000552158","url":null,"abstract":"<p><strong>Introduction: </strong>Rhegmatogenous retinal detachment (RRD) associated with giant retinal tears (GRTs) are treated with vitrectomy but choice of intraocular tamponade is difficult and practice varies amongst vitreoretinal surgeons. We sought to investigate the variables that determine choice of tamponade and how these may affect anatomical and visual outcomes.</p><p><strong>Method: </strong>Cohort study of routinely collected data from the European Society of Retina Specialists and British and Eire Association of Vitreoretinal Surgeons vitreoretinal surgery outcomes database between 2011 and 2024. Consecutive eyes with GRT and primary RRD surgery that had vitrectomy, and either gas or silicone oil (SO), were included. Revision surgery or secondary causes of GRT including trauma and inflammation were excluded. The type of tamponade used was analysed by a range of baseline variables including macular status, GRT extent and the lowest GRT extent. Multivariable logistic and linear regression were used to investigate the association between baseline variables and surgical technique, including tamponade choice, on primary anatomical success and postoperative visual acuity (VA).</p><p><strong>Results: </strong>215 eyes with GRT associated RRD were analysed. The mean age was 53 years, 80% were male, 63% phakic, and 7% had proliferative vitreoretinopathy (PVR) grade C. 58% of the cases were macula on. Overall, 50% of the eyes received SO tamponade and 50% gas. SO was used in more of the macula off cases and in eyes with larger GRTs. Overall, 187 of the 215 (87%) eyes achieved primary anatomical success, with 88% of gas tamponade cases achieving primary success versus 86% of the oil cases. Data on visual outcomes were available on 196 eyes of the 215 eyes. Overall, 57% of these eyes achieved 0.3 logMAR postoperative VA or better, with higher percentages in the gas compared to the oil group (78% versus 36%). Multivariable analysis found that tamponade type was not associated with anatomical outcome. The only factor associated with a reduced anatomical success rate was PVR C (odds ratio [OR] 0.29 (95% confidence interval (CI) 0.09-0.90) p = 0.03). Multivariable analysis found that postoperative VA was significantly better with gas compared to SO with oil. Overall, the odds of achieving a VA of 0.3 logMAR or better were at least 2 times higher with gas as compared to oil (OR 4.65 (95% CI: 2.41, 8.99), p < 0.001), rising to at least 5 times higher in the subgroup of patients with a VA of 0.3 logMAR or better at baseline (OR 17.56 (95% CI 5.15, 59.89), p < 0.001).</p><p><strong>Conclusion: </strong>Our results show that gas tamponade has a similar anatomical success rate to SO, but better visual outcomes in the repair of GRT-associated RRD. Further studies are needed to confirm these findings and inform tamponade choice.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"374-385"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}