IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 DOI: 10.1016/j.neuron.2025.05.011

Lucrezia Floro, Julia Tcw

引用次数: 0

Slowing the drive: A new regulatory break for nicotine reward-related behaviors. 减缓动力：对尼古丁奖励相关行为的新监管突破。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 DOI: 10.1016/j.neuron.2025.05.012

Brandon J Henderson

引用次数: 0

The neuroscience of misinformation: A research agenda 错误信息的神经科学：一个研究议程

IF 16.2 1区医学

Neuron Pub Date : 2025-06-13 DOI: 10.1016/j.neuron.2025.05.010

Sander van der Linden, Michael S. Cohen

引用次数: 0

Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility 重度抑郁症相关的ZBTB7A在眶额叶皮层的失调促进星形胶质细胞介导的应激易感性

IF 16.2 1区医学

Neuron Pub Date : 2025-06-13 DOI: 10.1016/j.neuron.2025.05.023

Sasha L. Fulton, Jaroslav Bendl, Giuseppina Di Salvo, John F. Fullard, Amni Al-Kachak, Ashley E. Lepack, Andrew F. Stewart, Sumnima Singh, Wolfram F. Poller, Ryan M. Bastle, Mads E. Hauberg, Amanda K. Fakira, Vishwendra Patel, Min Chen, Romain Durand-de Cuttoli, Isabel Gameiro-Ros, Flurin Cathomas, Aarthi Ramakrishnan, Kelly Gleason, Li Shen, Carol A. Tamminga, Ana Milosevic, Scott J. Russo, Filip K. Swirski, Paul A. Slesinger, Ishmail Abdus-Saboor, Robert D. Blitzer, Panos Roussos, Ian Maze

{"title":"Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility","authors":"Sasha L. Fulton, Jaroslav Bendl, Giuseppina Di Salvo, John F. Fullard, Amni Al-Kachak, Ashley E. Lepack, Andrew F. Stewart, Sumnima Singh, Wolfram F. Poller, Ryan M. Bastle, Mads E. Hauberg, Amanda K. Fakira, Vishwendra Patel, Min Chen, Romain Durand-de Cuttoli, Isabel Gameiro-Ros, Flurin Cathomas, Aarthi Ramakrishnan, Kelly Gleason, Li Shen, Carol A. Tamminga, Ana Milosevic, Scott J. Russo, Filip K. Swirski, Paul A. Slesinger, Ishmail Abdus-Saboor, Robert D. Blitzer, Panos Roussos, Ian Maze","doi":"10.1016/j.neuron.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.023","url":null,"abstract":"Heightened activity in the orbitofrontal cortex (OFC), a brain region that contributes to motivation, emotion, and reward-related decision-making, is a key clinical feature of major depressive disorder (MDD). However, the cellular and molecular substrates underlying this dysfunction remain unclear. Here, we performed cell-type-specific profiling of human OFC and unexpectedly mapped MDD-linked epigenomic features (including genetic risk variants) to non-neuronal cells, revealing significant glial dysregulation in this region. Characterization of MDD-specific chromatin loci further identified ZBTB7A—a transcriptional regulator of astrocyte reactivity—as an important mediator of MDD-related alterations. In rodent models, we found that Zbtb7a induction in astrocytes is both necessary and sufficient to drive stress-mediated behavioral deficits, cell-type-specific transcriptional/epigenomic signatures, and aberrant OFC astrocyte-neuronal communication in male mice—an established MDD risk factor. These findings thus highlight essential roles for astrocytes in OFC-mediated stress susceptibility and identify ZBTB7A as a critical and therapeutically relevant regulator of MDD-related OFC dysfunction.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"12 1","pages":""},"PeriodicalIF":16.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light, opsins, and life: Mammalian photophysiological functions beyond image perception. 光、视蛋白和生命：哺乳动物的光生理功能超越图像感知。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-12 DOI: 10.1016/j.neuron.2025.05.025

Yiming Shi, Jiaxi Hu, Tian Xue

{"title":"Light, opsins, and life: Mammalian photophysiological functions beyond image perception.","authors":"Yiming Shi, Jiaxi Hu, Tian Xue","doi":"10.1016/j.neuron.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.025","url":null,"abstract":"Light, a fundamental form of energy and sensory input, has significantly shaped life forms on Earth. In mammals, light perception through the eyes, which enables image formation, is crucial for survival. However, beyond image-forming (IF) vision, light also mediates non-image-forming (NIF) functions, such as circadian photoentrainment and the pupillary light reflex. Recent studies have further demonstrated that light influences a wide range of physiological and behavioral processes, including mood, metabolism, cognition, pain perception, sleep, and neuronal development. The diverse types of opsins, the major photosensitive proteins in mammals, are expressed not only in the rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) of the retina but also in extraocular tissues, such as the brain, skin, and adipose tissue. Opsins in both ocular and extraocular tissues jointly contribute to light detection and mediate diverse NIF functions. In this review, we focus on the NIF effects of light on mammals, emphasizing its regulation of physiological functions as well as the corresponding roles of light receptors and associated neuronal circuits. It also highlights the implications of these findings for human health, underscoring the need for a comprehensive understanding of the interactions between light and life.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning. 电压成像揭示了神经中脑的电路计算，其基础是血清素介导的运动活力学习。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-10 DOI: 10.1016/j.neuron.2025.05.017

Takashi Kawashima, Ziqiang Wei, Ravid Haruvi, Inbal Shainer, Sujatha Narayan, Herwig Baier, Misha B Ahrens

{"title":"Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning.","authors":"Takashi Kawashima, Ziqiang Wei, Ravid Haruvi, Inbal Shainer, Sujatha Narayan, Herwig Baier, Misha B Ahrens","doi":"10.1016/j.neuron.2025.05.017","DOIUrl":"10.1016/j.neuron.2025.05.017","url":null,"abstract":"As animals adapt to new situations, neuromodulation is a potent way to alter behavior, yet mechanisms by which neuromodulatory nuclei compute during behavior are underexplored. The serotonergic raphe supports motor learning in larval zebrafish by visually detecting distance traveled during swims, encoding action effectiveness, and modulating motor vigor. We tracked the raphe's input-output computations at millisecond timescales using voltage and neurotransmitter imaging and found that swimming opens a gate for visual input to cause spiking in serotonergic neurons, enabling the encoding of action outcomes and filtering out learning-irrelevant visual signals. Specifically, swim commands initially inhibited serotonergic neurons via γ-aminobutyric acid (GABA). Immediately after, membrane voltage increased via post-inhibitory rebound, allowing swim-induced visual motion to evoke firing through glutamate, triggering serotonin release to modulate future motor vigor. Ablating local GABAergic neurons impaired raphe coding and motor learning. Thus, serotonergic neuromodulation arises from action-outcome coincidence detection within the raphe.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Will our social brain inherently shape and be shaped by interactions with AI? 我们的社交大脑是否会在与人工智能的互动中固有地塑造或被塑造？

IF 14.7 1区医学

Neuron Pub Date : 2025-06-07 DOI: 10.1016/j.neuron.2025.04.034

Benjamin Becker

引用次数: 0

Locus coeruleus activation "resets" hippocampal event representations and separates adjacent memories. 蓝斑激活“重置”海马体事件表征并分离相邻记忆。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-06 DOI: 10.1016/j.neuron.2025.05.013

David Clewett, Ringo Huang, Lila Davachi

引用次数: 0

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics. R6/2 HD小鼠大脑中不同的分子模式：来自时空转录组学的见解。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-06 DOI: 10.1016/j.neuron.2025.05.014

Mara S Burns, Ricardo Miramontes, Jie Wu, Ravinder Gulia, Madhu S Saddala, Alice L Lau, Tiffany Quach, John C Reidling, Vivek Swarup, Albert R La Spada, Ryan G Lim, Leslie M Thompson

{"title":"Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics.","authors":"Mara S Burns, Ricardo Miramontes, Jie Wu, Ravinder Gulia, Madhu S Saddala, Alice L Lau, Tiffany Quach, John C Reidling, Vivek Swarup, Albert R La Spada, Ryan G Lim, Leslie M Thompson","doi":"10.1016/j.neuron.2025.05.014","DOIUrl":"10.1016/j.neuron.2025.05.014","url":null,"abstract":"Huntington's disease (HD) is marked by widespread cellular dysregulation. To understand disease mechanisms, we and others have utilized bulk and single-cell transcriptomics, which provide cell-type information but limited spatial information. We used 10× Genomics Visium spatial transcriptomics integrated with matched single-nuclei RNA sequencing (snRNA-seq) in the rapidly progressing HD R6/2 mouse brain (post-natal day 0 [P0], 4 weeks, and 12 weeks). Our data suggest regional, temporal, and cell-type-specific regulatory pathways that establish distinct gene expression changes. Synaptic dysfunction is observed broadly throughout the brain, whereas we observed early dysregulation of the transcription factor 4 (Tcf4) that may drive cortical changes. Mitochondrial deficits are the earliest changes, beginning at P0 in the striatum. Striatal identity genes show early increased expression that becomes progressively downregulated. Finally, we identified a time-dependent dysregulation of neuropeptide Y signaling and potential interaction with the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway, which may be involved in the imbalance between Drd1 and Drd2 neuron vulnerability.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions. 星形胶质细胞和神经元的细胞表面共享蛋白质组及其多细胞相互作用的分子基础。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-05 DOI: 10.1016/j.neuron.2025.05.019

Ling Wu, Vijaya Pandey, Vanessa H Casha, Zhe Qu, Yasaman Jami-Alahmadi, Viviana Gradinaru, James A Wohlschlegel, Baljit S Khakh

{"title":"The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions.","authors":"Ling Wu, Vijaya Pandey, Vanessa H Casha, Zhe Qu, Yasaman Jami-Alahmadi, Viviana Gradinaru, James A Wohlschlegel, Baljit S Khakh","doi":"10.1016/j.neuron.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.019","url":null,"abstract":"Neurons and astrocytes are predominant brain cells that extensively interact, but the molecular basis of their interactions remains largely unexplored. We identified and mapped striatal astrocytic and neuronal cell-surface proteins (CSPs) and found that many were shared, representing the cell-surface shared proteome of astrocytes and neurons (CS SPAN) bridging striatal astrocyte-neuron interaction sites. CS SPAN was replete with extracellular matrix proteins, cell adhesion molecules, transporters, ion channels, and G protein-coupled receptors. By mapping the cellular origins of astrocytic CSPs, we identified astrocytic interactions with diverse parenchymal cells. Broadly concordant with human data, in a mouse model of Huntington's disease (HD), pathophysiology and its genetic attenuation were accompanied by altered and restored CS SPAN and CSPs, respectively. CS SPAN also included molecules dysregulated in diverse brain disorders. Our study reveals the astrocyte-neuron interface in molecular terms and provides a mechanistic foundation for exploring its physiological roles and contributions to brain diseases.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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