Neuron最新文献_第4页

Sexual dimorphism in cerebrovascular dysfunction: The pivotal role of endothelial CD2AP in Alzheimer's disease.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 DOI: 10.1016/j.neuron.2025.02.022

Hong Bao, Shuxin Zheng, Yong Shen

引用次数: 0

Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-01-28 DOI: 10.1016/j.neuron.2025.01.002

Hermany Munguba, Ipsit Srivastava, Vanessa A Gutzeit, Ashna Singh, Akshara Vijay, Melanie Kristt, Anisul Arefin, Sonal Thukral, Johannes Broichhagen, Joseph M Stujenske, Conor Liston, Joshua Levitz

{"title":"Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses.","authors":"Hermany Munguba, Ipsit Srivastava, Vanessa A Gutzeit, Ashna Singh, Akshara Vijay, Melanie Kristt, Anisul Arefin, Sonal Thukral, Johannes Broichhagen, Joseph M Stujenske, Conor Liston, Joshua Levitz","doi":"10.1016/j.neuron.2025.01.002","DOIUrl":"10.1016/j.neuron.2025.01.002","url":null,"abstract":"Dissecting how membrane receptors regulate neural circuits is critical for deciphering principles of neuromodulation and mechanisms of drug action. Here, we use a battery of optical approaches to determine how presynaptic metabotropic glutamate receptor 2 (mGluR2) in the basolateral amygdala (BLA) controls anxiety-related behavior in mice. Using projection-specific photopharmacological activation, we find that mGluR2-mediated presynaptic inhibition of ventromedial prefrontal cortex (vmPFC)-BLA, but not posterior insular cortex (pIC)-BLA, connections produces a long-lasting decrease in spatial avoidance. In contrast, presynaptic inhibition of pIC-BLA connections decreases social avoidance and novelty-induced hypophagia without impairing working memory, establishing this projection as a novel target for the treatment of anxiety disorders. Fiber photometry and viral mapping reveal distinct activity patterns and anatomical organization of vmPFC-BLA and pIC-BLA circuits. Together, this work reveals new aspects of BLA neuromodulation with therapeutic implications while establishing a powerful approach for optical mapping of drug action.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"912-930.e6"},"PeriodicalIF":14.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop modulation of remote hippocampal representations with neurofeedback. 基于神经反馈的远端海马表征闭环调制。

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-01-20 DOI: 10.1016/j.neuron.2024.12.023

Michael E Coulter, Anna K Gillespie, Joshua Chu, Eric L Denovellis, Trevor Thai K Nguyen, Daniel F Liu, Katherine Wadhwani, Baibhav Sharma, Kevin Wang, Xinyi Deng, Uri T Eden, Caleb Kemere, Loren M Frank

{"title":"Closed-loop modulation of remote hippocampal representations with neurofeedback.","authors":"Michael E Coulter, Anna K Gillespie, Joshua Chu, Eric L Denovellis, Trevor Thai K Nguyen, Daniel F Liu, Katherine Wadhwani, Baibhav Sharma, Kevin Wang, Xinyi Deng, Uri T Eden, Caleb Kemere, Loren M Frank","doi":"10.1016/j.neuron.2024.12.023","DOIUrl":"10.1016/j.neuron.2024.12.023","url":null,"abstract":"Humans can remember specific remote events without acting on them and influence which memories are retrieved based on internal goals. However, animal models typically present sensory cues to trigger memory retrieval and then assess retrieval based on action. Thus, it is difficult to determine whether measured neural activity patterns relate to the cue(s), the memory, or the behavior. We therefore asked whether retrieval-related neural activity could be generated in animals without cues or a behavioral report. We focused on hippocampal \"place cells,\" which primarily represent the animal's current location (local representations) but can also represent locations away from the animal (remote representations). We developed a neurofeedback system to reward expression of remote representations and found that rats could learn to generate specific spatial representations that often jumped directly to the experimenter-defined target location. Thus, animals can deliberately engage remote representations, enabling direct study of retrieval-related activity in the brain.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"949-961.e3"},"PeriodicalIF":14.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of neurotechnology: From big data to translation.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-03-10 DOI: 10.1016/j.neuron.2025.02.019

Jinhyun Kim, Thomas J McHugh, Chul Hoon Kim, Hakwan Lau, Min-Ho Nam

引用次数: 0

A look into the future: Your biological sex may guide chronic pain treatment.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 DOI: 10.1016/j.neuron.2025.02.008

Marzia Malcangio, George Sideris-Lampretsas

引用次数: 0

Sleep stages antagonistically modulate reactivation drift.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 DOI: 10.1016/j.neuron.2025.02.025

Lars Bollmann, Peter Baracskay, Federico Stella, Jozsef Csicsvari

引用次数: 0

Calm in the chaos: Targeting mTOR to reduce glioma-driven neuronal hyperexcitability.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 DOI: 10.1016/j.neuron.2025.02.020

Matthia A Karreman, Varun Venkataramani

引用次数: 0

Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-01-31 DOI: 10.1016/j.neuron.2025.01.006

Milène Vandal, Adam Institoris, Louise Reveret, Ben Korin, Colin Gunn, Sotaro Hirai, Yulan Jiang, Sukyoung Lee, Jiyeon Lee, Philippe Bourassa, Ramesh C Mishra, Govind Peringod, Faye Arellano, Camille Belzil, Cyntia Tremblay, Mada Hashem, Kelsea Gorzo, Esteban Elias, Jinjing Yao, Bill Meilandt, Oded Foreman, Meron Roose-Girma, Steven Shin, Daniel Muruve, Wilten Nicola, Jakob Körbelin, Jeff F Dunn, Wayne Chen, Sang-Ki Park, Andrew P Braun, David A Bennett, Grant R J Gordon, Frédéric Calon, Andrey S Shaw, Minh Dang Nguyen

{"title":"Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction.","authors":"Milène Vandal, Adam Institoris, Louise Reveret, Ben Korin, Colin Gunn, Sotaro Hirai, Yulan Jiang, Sukyoung Lee, Jiyeon Lee, Philippe Bourassa, Ramesh C Mishra, Govind Peringod, Faye Arellano, Camille Belzil, Cyntia Tremblay, Mada Hashem, Kelsea Gorzo, Esteban Elias, Jinjing Yao, Bill Meilandt, Oded Foreman, Meron Roose-Girma, Steven Shin, Daniel Muruve, Wilten Nicola, Jakob Körbelin, Jeff F Dunn, Wayne Chen, Sang-Ki Park, Andrew P Braun, David A Bennett, Grant R J Gordon, Frédéric Calon, Andrey S Shaw, Minh Dang Nguyen","doi":"10.1016/j.neuron.2025.01.006","DOIUrl":"10.1016/j.neuron.2025.01.006","url":null,"abstract":"Polymorphisms in CD2-associated protein (CD2AP) predispose to Alzheimer's disease (AD), but the underlying mechanisms remain unknown. Here, we show that loss of CD2AP in cerebral blood vessels is associated with cognitive decline in AD subjects and that genetic downregulation of CD2AP in brain vascular endothelial cells impairs memory function in male mice. Animals with reduced brain endothelial CD2AP display altered blood flow regulation at rest and during neurovascular coupling, defects in mural cell activity, and an abnormal vascular sex-dependent response to Aβ. Antagonizing endothelin-1 receptor A signaling partly rescues the vascular impairments, but only in male mice. Treatment of CD2AP mutant mice with reelin glycoprotein that mitigates the effects of CD2AP loss function via ApoER2 increases resting cerebral blood flow and even protects male mice against the noxious effect of Aβ. Thus, endothelial CD2AP plays critical roles in cerebrovascular functions and represents a novel target for sex-specific treatment in AD.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"876-895.e11"},"PeriodicalIF":14.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slow cortical dynamics generate context processing and novelty detection.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-02-10 DOI: 10.1016/j.neuron.2025.01.011

Yuriy Shymkiv, Jordan P Hamm, Sean Escola, Rafael Yuste

{"title":"Slow cortical dynamics generate context processing and novelty detection.","authors":"Yuriy Shymkiv, Jordan P Hamm, Sean Escola, Rafael Yuste","doi":"10.1016/j.neuron.2025.01.011","DOIUrl":"10.1016/j.neuron.2025.01.011","url":null,"abstract":"The cortex amplifies responses to novel stimuli while suppressing redundant ones. Novelty detection is necessary to efficiently process sensory information and build predictive models of the environment, and it is also altered in schizophrenia. To investigate the circuit mechanisms underlying novelty detection, we used an auditory \"oddball\" paradigm and two-photon calcium imaging to measure responses to simple and complex stimuli across mouse auditory cortex. Stimulus statistics and complexity generated specific responses across auditory areas. Neuronal ensembles reliably encoded auditory features and temporal context. Interestingly, stimulus-evoked population responses were particularly long lasting, reflecting stimulus history and affecting future responses. These slow cortical dynamics encoded stimulus temporal context and generated stronger responses to novel stimuli. Recurrent neural network models trained on the oddball task also exhibited slow network dynamics and recapitulated the biological data. We conclude that the slow dynamics of recurrent cortical networks underlie processing and novelty detection.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"847-857.e8"},"PeriodicalIF":14.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The night's watch: Exploring how sleep protects against neurodegeneration. 夜晚的守望探索睡眠如何防止神经退化

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-03-06 DOI: 10.1016/j.neuron.2025.02.004

Samira Parhizkar, David M Holtzman

引用次数: 0