发布求助
文献互助 智能选刊 最新文献

Neuron最新文献

筛选
英文 中文
Functional architecture of cerebral cortex during naturalistic movie watching. 自然观影过程中大脑皮层的功能结构。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-25 DOI: 10.1016/j.neuron.2024.10.005
Reza Rajimehr, Haoran Xu, Asa Farahani, Simon Kornblith, John Duncan, Robert Desimone
{"title":"Functional architecture of cerebral cortex during naturalistic movie watching.","authors":"Reza Rajimehr, Haoran Xu, Asa Farahani, Simon Kornblith, John Duncan, Robert Desimone","doi":"10.1016/j.neuron.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.10.005","url":null,"abstract":"<p><p>Characterizing the functional organization of cerebral cortex is a fundamental step in understanding how different kinds of information are processed in the brain. However, it is still unclear how these areas are organized during naturalistic visual and auditory stimulation. Here, we used high-resolution functional MRI data from 176 human subjects to map the macro-architecture of the entire cerebral cortex based on responses to a 60-min audiovisual movie stimulus. A data-driven clustering approach revealed a map of 24 functional areas/networks, each explicitly linked to a specific aspect of sensory or cognitive processing. Novel features of this map included an extended scene-selective network in the lateral prefrontal cortex, separate clusters responsive to human-object and human-human interaction, and a push-pull interaction between three executive control (domain-general) networks and domain-specific regions of the visual, auditory, and language cortex. Our cortical parcellation provides a comprehensive and unified map of functionally defined areas in the human cerebral cortex.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental complexity modulates information processing and the balance between decision-making systems. 环境的复杂性会调节信息处理和决策系统之间的平衡。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-24 DOI: 10.1016/j.neuron.2024.10.004
Ugurcan Mugan, Samantha L Hoffman, A David Redish
{"title":"Environmental complexity modulates information processing and the balance between decision-making systems.","authors":"Ugurcan Mugan, Samantha L Hoffman, A David Redish","doi":"10.1016/j.neuron.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.10.004","url":null,"abstract":"<p><p>Behavior in naturalistic scenarios occurs in diverse environments. Adaptive strategies rely on multiple neural circuits and competing decision systems. However, past studies of rodent decision making have largely measured behavior in simple environments. To fill this gap, we recorded neural ensembles from hippocampus (HC), dorsolateral striatum (DLS), and dorsomedial prefrontal cortex (dmPFC) while rats foraged for food under changing rules in environments with varying topological complexity. Environmental complexity increased behavioral variability, lengthened HC nonlocal sequences, and modulated action caching. We found contrasting representations between DLS and HC, supporting a competition between decision systems. dmPFC activity was indicative of setting this balance, in particular predicting the extent of HC non-local coding. Inactivating mPFC impaired short-term behavioral adaptation and produced long-term deficits in balancing decision systems. Our findings reveal the dynamic nature of decision-making systems and how environmental complexity modulates their engagement with implications for behavior in naturalistic environments.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When rewards backfire: Collapsing under pressure in motor cortex. 当奖励适得其反时运动皮层在压力下崩溃
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 DOI: 10.1016/j.neuron.2024.09.022
Mojtaba Abbaszadeh, Becket Ebitz
{"title":"When rewards backfire: Collapsing under pressure in motor cortex.","authors":"Mojtaba Abbaszadeh, Becket Ebitz","doi":"10.1016/j.neuron.2024.09.022","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.09.022","url":null,"abstract":"<p><p>People often underperform their abilities in high-value situations, a mysterious phenomenon known as \"choking under pressure.\" In this issue of Neuron, Smoulder et al.<sup>1</sup> report that target-selective signals in the motor cortex of non-human primates collapse in the face of high-value opportunities.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"112 20","pages":"3373-3375"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions. 运动皮层负责纹状体的运动动力以及熟练和非熟练动作的执行。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-08-20 DOI: 10.1016/j.neuron.2024.07.022
Mark A Nicholas, Eric A Yttri
{"title":"Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions.","authors":"Mark A Nicholas, Eric A Yttri","doi":"10.1016/j.neuron.2024.07.022","DOIUrl":"10.1016/j.neuron.2024.07.022","url":null,"abstract":"<p><p>Striatum and its predominant input, motor cortex, are responsible for the selection and performance of purposive movement, but how their interaction guides these processes is not understood. To establish its neural and behavioral contributions, we bilaterally lesioned motor cortex and recorded striatal activity and reaching performance daily, capturing the lesion's direct ramifications within hours of the intervention. We observed reaching impairment and an absence of striatal motoric activity following lesion of motor cortex, but not parietal cortex control lesions. Although some aspects of performance began to recover after 8-10 days, striatal projection and interneuronal dynamics did not-eventually entering a non-motor encoding state that aligned with persisting kinematic control deficits. Lesioned mice also exhibited a profound inability to switch motor plans while locomoting, reminiscent of clinical freezing of gait (FOG). Our results demonstrate the necessity of motor cortex in generating trained and untrained actions as well as striatal motoric dynamics.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3486-3501.e5"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurobehavioral meaning of pupil size. 瞳孔大小的神经行为学意义。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-06-25 DOI: 10.1016/j.neuron.2024.05.029
Nikola Grujic, Rafael Polania, Denis Burdakov
{"title":"Neurobehavioral meaning of pupil size.","authors":"Nikola Grujic, Rafael Polania, Denis Burdakov","doi":"10.1016/j.neuron.2024.05.029","DOIUrl":"10.1016/j.neuron.2024.05.029","url":null,"abstract":"<p><p>Pupil size is a widely used metric of brain state. It is one of the few signals originating from the brain that can be readily monitored with low-cost devices in basic science, clinical, and home settings. It is, therefore, important to investigate and generate well-defined theories related to specific interpretations of this metric. What exactly does it tell us about the brain? Pupils constrict in response to light and dilate during darkness, but the brain also controls pupil size irrespective of luminosity. Pupil size fluctuations resulting from ongoing \"brain states\" are used as a metric of arousal, but what is pupil-linked arousal and how should it be interpreted in neural, cognitive, and computational terms? Here, we discuss some recent findings related to these issues. We identify open questions and propose how to answer them through a combination of well-defined tasks, neurocomputational models, and neurophysiological probing of the interconnected loops of causes and consequences of pupil size.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3381-3395"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. 苍白球介导可卡因诱导行为可塑性控制的分子和回路决定因素
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-08-16 DOI: 10.1016/j.neuron.2024.07.018
Guilian Tian, Katrina Bartas, May Hui, Lingxuan Chen, Jose J Vasquez, Ghalia Azouz, Pieter Derdeyn, Rían W Manville, Erick L Ho, Amanda S Fang, Yuan Li, Isabella Tyler, Vincent Setola, Jason Aoto, Geoffrey W Abbott, Kevin T Beier
{"title":"Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.","authors":"Guilian Tian, Katrina Bartas, May Hui, Lingxuan Chen, Jose J Vasquez, Ghalia Azouz, Pieter Derdeyn, Rían W Manville, Erick L Ho, Amanda S Fang, Yuan Li, Isabella Tyler, Vincent Setola, Jason Aoto, Geoffrey W Abbott, Kevin T Beier","doi":"10.1016/j.neuron.2024.07.018","DOIUrl":"10.1016/j.neuron.2024.07.018","url":null,"abstract":"<p><p>The globus pallidus externus (GPe) is a central component of the basal ganglia circuit that acts as a gatekeeper of cocaine-induced behavioral plasticity. However, the molecular and circuit mechanisms underlying this function are unknown. Here, we show that GPe parvalbumin-positive (GPe<sup>PV</sup>) cells mediate cocaine responses by selectively modulating ventral tegmental area dopamine (VTA<sup>DA</sup>) cells projecting to the dorsomedial striatum (DMS). Interestingly, GPe<sup>PV</sup> cell activity in cocaine-naive mice is correlated with behavioral responses following cocaine, effectively predicting cocaine sensitivity. Expression of the voltage-gated potassium channels KCNQ3 and KCNQ5 that control intrinsic cellular excitability following cocaine was downregulated, contributing to the elevation in GPe<sup>PV</sup> cell excitability. Acutely activating channels containing KCNQ3 and/or KCNQ5 using the small molecule carnosic acid, a key psychoactive component of Salvia rosmarinus (rosemary) extract, reduced GPe<sup>PV</sup> cell excitability and impaired cocaine reward, sensitization, and volitional cocaine intake, indicating its therapeutic potential to counteract psychostimulant use disorder.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3470-3485.e12"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. 剪接体 GTPase Eftud2 缺乏引发的铁突变会导致浦肯野细胞变性。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-08-16 DOI: 10.1016/j.neuron.2024.07.020
Guochao Yang, Yinghong Yang, Zhihong Song, Liping Chen, Fengjiao Liu, Ying Li, Shaofei Jiang, Saisai Xue, Jie Pei, Yan Wu, Yuanlin He, Bo Chu, Haitao Wu
{"title":"Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.","authors":"Guochao Yang, Yinghong Yang, Zhihong Song, Liping Chen, Fengjiao Liu, Ying Li, Shaofei Jiang, Saisai Xue, Jie Pei, Yan Wu, Yuanlin He, Bo Chu, Haitao Wu","doi":"10.1016/j.neuron.2024.07.020","DOIUrl":"10.1016/j.neuron.2024.07.020","url":null,"abstract":"<p><p>Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2 (EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) syndrome comprising cerebellar hypoplasia and motor dysfunction. How EFTUD2 deficiency contributes to these symptoms remains elusive. Here, we demonstrate that specific ablation of Eftud2 in cerebellar Purkinje cells (PCs) in mice results in severe ferroptosis, PC degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with MFDM. Mechanistically, Eftud2 promotes Scd1 and Gch1 expression, upregulates monounsaturated fatty acid phospholipids, and enhances antioxidant activity, thereby suppressing PC ferroptosis. Importantly, we identified transcription factor Atf4 as a downstream target to regulate anti-ferroptosis effects in PCs in a p53-independent manner. Inhibiting ferroptosis efficiently rescued cerebellar deficits in Eftud2 cKO mice. Our data reveal an important role of Eftud2 in maintaining PC survival, showing that pharmacologically or genetically inhibiting ferroptosis may be a promising therapeutic strategy for EFTUD2 deficiency-induced disorders.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3452-3469.e9"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A protective role for EFTUD2 in the brain. EFTUD2 在大脑中的保护作用
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 DOI: 10.1016/j.neuron.2024.10.003
Marie-Claude Beauchamp, Loydie A Jerome-Majewska
{"title":"A protective role for EFTUD2 in the brain.","authors":"Marie-Claude Beauchamp, Loydie A Jerome-Majewska","doi":"10.1016/j.neuron.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.10.003","url":null,"abstract":"<p><p>In this issue of Neuron, Yang et al.<sup>1</sup> report MFDM-like phenotypes in mice with deletion of Eftud2 in their Purkinje cells (PCs), namely cerebellar atrophy alongside motor and social deficits, similar to phenotypes observed in MFDM patients. The absence of Eftud2 caused mis-splicing of Atf4, reduced Scd1 and Gch1, and promoted ferroptosis-regulated PC death.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"112 20","pages":"3378-3380"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flexible control of sequence working memory in the macaque frontal cortex. 猕猴额叶皮层对序列工作记忆的灵活控制
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-08-22 DOI: 10.1016/j.neuron.2024.07.024
Jingwen Chen, Cong Zhang, Peiyao Hu, Bin Min, Liping Wang
{"title":"Flexible control of sequence working memory in the macaque frontal cortex.","authors":"Jingwen Chen, Cong Zhang, Peiyao Hu, Bin Min, Liping Wang","doi":"10.1016/j.neuron.2024.07.024","DOIUrl":"10.1016/j.neuron.2024.07.024","url":null,"abstract":"<p><p>To memorize a sequence, one must serially bind each item to its rank order. How the brain controls a given input to bind its associated order in sequence working memory (SWM) remains unexplored. Here, we investigated the neural representations underlying SWM control using electrophysiological recordings in the frontal cortex of macaque monkeys performing forward and backward SWM tasks. Separate and generalizable low-dimensional subspaces for sensory and memory information were found within the same frontal circuitry, and SWM control was reflected in these neural subspaces' organized dynamics. Each item at each rank was sequentially entered into a common sensory subspace and, depending on forward or backward task requirement, flexibly and timely sent into rank-selective SWM subspaces. Neural activity in these SWM subspaces faithfully predicted the recalled item and order information in single error trials. Thus, compositional neural population codes with well-orchestrated dynamics in frontal cortex support the flexible control of SWM.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3502-3514.e6"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice. 星形胶质细胞 Gi-GPCR 信号可纠正 Sapap3 基因敲除小鼠的强迫性梳理和焦虑相关行为。
IF 14.7 1区 医学
Neuron Pub Date : 2024-10-23 Epub Date: 2024-08-19 DOI: 10.1016/j.neuron.2024.07.019
Joselyn S Soto, Chiranjivi Neupane, Muskan Kaur, Vijaya Pandey, James A Wohlschlegel, Baljit S Khakh
{"title":"Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice.","authors":"Joselyn S Soto, Chiranjivi Neupane, Muskan Kaur, Vijaya Pandey, James A Wohlschlegel, Baljit S Khakh","doi":"10.1016/j.neuron.2024.07.019","DOIUrl":"10.1016/j.neuron.2024.07.019","url":null,"abstract":"<p><p>Astrocytes are morphologically complex cells that serve essential roles. They are widely implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology and gene expression accompanying disease. In the Sapap3 knockout (KO) mouse model of compulsive and anxiety-related behaviors related to obsessive-compulsive disorder (OCD), striatal astrocytes display reduced morphology and altered actin cytoskeleton and Gi-G-protein-coupled receptor (Gi-GPCR) signaling proteins. Here, we show that normalizing striatal astrocyte morphology, actin cytoskeleton, and essential homeostatic support functions by targeting the astrocyte Gi-GPCR pathway using chemogenetics corrected phenotypes in Sapap3 KO mice, including anxiety-related and compulsive behaviors. Our data portend an astrocytic pharmacological strategy for rescuing phenotypes in brain disorders that include compromised astrocyte morphology and tissue support.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3412-3423.e6"},"PeriodicalIF":14.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信