IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-03-06 DOI: 10.1016/j.neuron.2025.02.004

Samira Parhizkar, David M Holtzman

引用次数: 0

The neuroscience of dance takes center stage.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-19 Epub Date: 2025-03-10 DOI: 10.1016/j.neuron.2025.01.016

Emily S Cross

引用次数: 0

Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-18 DOI: 10.1016/j.neuron.2025.02.021

Federica Lucantonio, Jacob Roeglin, Shuwen Li, Jaden Lu, Aleesha Shi, Katherine Czerpaniak, Francesca R Fiocchi, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatelli

{"title":"Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.","authors":"Federica Lucantonio, Jacob Roeglin, Shuwen Li, Jaden Lu, Aleesha Shi, Katherine Czerpaniak, Francesca R Fiocchi, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatelli","doi":"10.1016/j.neuron.2025.02.021","DOIUrl":"10.1016/j.neuron.2025.02.021","url":null,"abstract":"Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and synaptic changes are not well understood. Here, we show that the nucleus accumbens (NAc) is essential for ketamine's effect in rescuing anhedonia in mice subjected to chronic stress. Specifically, a single exposure to ketamine rescues stress-induced decreased strength of excitatory synapses on NAc-D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs). Using a cell-specific pharmacology method, we establish the necessity of this synaptic restoration for the sustained therapeutic effects of ketamine on anhedonia. Examining causal sufficiency, artificially increasing excitatory synaptic strength onto D1-MSNs recapitulates the behavioral amelioration induced by ketamine. Finally, we used opto- and chemogenetic approaches to determine the presynaptic origin of the relevant synapses, implicating monosynaptic inputs from the medial prefrontal cortex and ventral hippocampus.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-17 DOI: 10.1016/j.neuron.2025.02.018

Patrycja M Forster, Manuel O Jakob, Dilmurat Yusuf, Marvin Bubeck, Heidi Limberger, Yanjiang Luo, Paula Thieme, Alexandra Polici, Nele Sterczyk, Sotiria Boulekou, Laura Bartel, Catalina Cosovanu, Mario Witkowski, Miguel González-Acera, Anja A Kühl, Carl Weidinger, Rolf Backofen, Ahmed N Hegazy, Jay V Patankar, Christoph S N Klose

{"title":"A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.","authors":"Patrycja M Forster, Manuel O Jakob, Dilmurat Yusuf, Marvin Bubeck, Heidi Limberger, Yanjiang Luo, Paula Thieme, Alexandra Polici, Nele Sterczyk, Sotiria Boulekou, Laura Bartel, Catalina Cosovanu, Mario Witkowski, Miguel González-Acera, Anja A Kühl, Carl Weidinger, Rolf Backofen, Ahmed N Hegazy, Jay V Patankar, Christoph S N Klose","doi":"10.1016/j.neuron.2025.02.018","DOIUrl":"10.1016/j.neuron.2025.02.018","url":null,"abstract":"Enteric infections often cause long-term sequelae, including persistent gastrointestinal symptoms, such as pain, discomfort, or irritable bowel syndrome. The plethora of sensory symptoms indicates that gut-innervating neurons might be directly affected by inflammation. However, sequencing studies of neurons in the gastrointestinal tract are hampered by difficulties in purifying neurons, especially during inflammation. Activating a nuclear GFP tag selectively in neurons enabled sort purification of intrinsic and extrinsic neurons of the gastrointestinal tract in models of intestinal inflammation. Using bulk and single-nucleus RNA sequencing, we mapped the whole transcriptomic landscape and identified a conserved neuronal response to inflammation, which included the interferon signaling and ferroptosis pathway. Deletion of the interferon receptor 1 in neurons regulated ferroptosis, neuronal loss, and consequently gut-transit time. Collectively, this study offers a resource documenting neuronal adaptation to inflammatory conditions and exposes the interferon and ferroptosis pathways as signaling cascades activated in neurons during inflammation.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience influences the refinement of feature selectivity in the mouse primary visual thalamus. 经验影响小鼠初级视觉丘脑特征选择性的完善

IF 14.7 1区医学

Neuron Pub Date : 2025-03-16 DOI: 10.1016/j.neuron.2025.02.023

Takuma Sonoda, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R Uzgare, Michela Fagiolini, Michael E Greenberg, Chinfei Chen

{"title":"Experience influences the refinement of feature selectivity in the mouse primary visual thalamus.","authors":"Takuma Sonoda, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R Uzgare, Michela Fagiolini, Michael E Greenberg, Chinfei Chen","doi":"10.1016/j.neuron.2025.02.023","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.02.023","url":null,"abstract":"Neurons exhibit selectivity for specific features: a property essential for extracting and encoding relevant information in the environment. This feature selectivity is thought to be modifiable by experience at the level of the cortex. Here, we demonstrate that selective exposure to a feature during development can alter the population representation of that feature in the primary visual thalamus. This thalamic plasticity is not due to changes in corticothalamic inputs and is blocked in mutant mice that exhibit deficits in retinogeniculate refinement, suggesting that plasticity is a direct result of changes in feedforward connectivity. Notably, experience-dependent changes in thalamic feature selectivity also occur in adult animals, although these changes are transient, unlike in juvenile animals, where they are long lasting. These results reveal an unexpected degree of plasticity in the visual thalamus and show that salient environmental features can be encoded in thalamic circuits during a discrete developmental window.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive nature of spontaneous brain activity across scales and species.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-13 DOI: 10.1016/j.neuron.2025.02.009

Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta

{"title":"The predictive nature of spontaneous brain activity across scales and species.","authors":"Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta","doi":"10.1016/j.neuron.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.02.009","url":null,"abstract":"Emerging research suggests the brain operates as a \"prediction machine,\" continuously anticipating sensory, motor, and cognitive outcomes. Central to this capability is the brain's spontaneous activity-ongoing internal processes independent of external stimuli. Neuroimaging and computational studies support that this activity is integral to maintaining and refining mental models of our environment, body, and behaviors, akin to generative models in computation. During rest, spontaneous activity expands the variability of potential representations, enhancing the accuracy and adaptability of these models. When performing tasks, internal models direct brain regions to anticipate sensory and motor states, optimizing performance. This review synthesizes evidence from various species, from C. elegans to humans, highlighting three key aspects of spontaneous brain activity's role in prediction: the similarity between spontaneous and task-related activity, the encoding of behavioral and interoceptive priors, and the high metabolic cost of this activity, underscoring prediction as a fundamental function of brains across species.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population coding of predator imminence in the hypothalamus.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-13 DOI: 10.1016/j.neuron.2025.02.003

Kathy Y M Cheung, Aditya Nair, Ling-Yun Li, Mikhail G Shapiro, David J Anderson

引用次数: 0

Interpretable deep learning for deconvolutional analysis of neural signals.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-12 DOI: 10.1016/j.neuron.2025.02.006

Bahareh Tolooshams, Sara Matias, Hao Wu, Simona Temereanca, Naoshige Uchida, Venkatesh N Murthy, Paul Masset, Demba Ba

{"title":"Interpretable deep learning for deconvolutional analysis of neural signals.","authors":"Bahareh Tolooshams, Sara Matias, Hao Wu, Simona Temereanca, Naoshige Uchida, Venkatesh N Murthy, Paul Masset, Demba Ba","doi":"10.1016/j.neuron.2025.02.006","DOIUrl":"10.1016/j.neuron.2025.02.006","url":null,"abstract":"The widespread adoption of deep learning to model neural activity often relies on \"black-box\" approaches that lack an interpretable connection between neural activity and network parameters. Here, we propose using algorithm unrolling, a method for interpretable deep learning, to design the architecture of sparse deconvolutional neural networks and obtain a direct interpretation of network weights in relation to stimulus-driven single-neuron activity through a generative model. We introduce our method, deconvolutional unrolled neural learning (DUNL), and demonstrate its versatility by applying it to deconvolve single-trial local signals across multiple brain areas and recording modalities. We uncover multiplexed salience and reward prediction error signals from midbrain dopamine neurons, perform simultaneous event detection and characterization in somatosensory thalamus recordings, and characterize the heterogeneity of neural responses in the piriform cortex and across striatum during unstructured, naturalistic experiments. Our work leverages advances in interpretable deep learning to provide a mechanistic understanding of neural activity.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-12 DOI: 10.1016/j.neuron.2025.02.014

Muhammad Ali, Jigyasha Timsina, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Anh Do, Gyujin Heo, Lihua Wang, Jen Gentsch, Suzanne E Schindler, John C Morris, David M Holtzman, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward N Wilson, Yann Le Guen, Rana R Khalid, Chloe Robins, David J Pulford, Rawan Tarawneh, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung, Carlos Cruchaga

{"title":"Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.","authors":"Muhammad Ali, Jigyasha Timsina, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Anh Do, Gyujin Heo, Lihua Wang, Jen Gentsch, Suzanne E Schindler, John C Morris, David M Holtzman, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward N Wilson, Yann Le Guen, Rana R Khalid, Chloe Robins, David J Pulford, Rawan Tarawneh, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung, Carlos Cruchaga","doi":"10.1016/j.neuron.2025.02.014","DOIUrl":"10.1016/j.neuron.2025.02.014","url":null,"abstract":"Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel. The identified proteins cluster in four different pseudo-trajectories groups spanning the AD continuum and were enriched in pathways including neuronal death, apoptosis, and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfunction (mid stages), brain plasticity and longevity (mid stages), and microglia-neuron crosstalk (late stages). Using machine learning, we created and validated highly accurate and replicable (area under the curve [AUC] > 0.90) models that predict AD biomarker positivity and clinical status. These models can also identify people that will convert to AD.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolving neurobiology of early-life stress.

IF 14.7 1区医学

Neuron Pub Date : 2025-03-11 DOI: 10.1016/j.neuron.2025.02.016

Matthew T Birnie, Tallie Z Baram

引用次数: 0

Neuron最新文献