Neuron最新文献 - Book学术

Meningeal neutrophil immune signaling influences behavioral adaptation following threat. 脑膜中性粒细胞免疫信号影响受威胁后的行为适应。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-13 DOI: 10.1016/j.neuron.2024.10.018

Bin Wu, Ling Meng, Yan Zhao, Junjie Li, Qiuyun Tian, Yayan Pang, Chunguang Ren, Zhifang Dong

{"title":"Meningeal neutrophil immune signaling influences behavioral adaptation following threat.","authors":"Bin Wu, Ling Meng, Yan Zhao, Junjie Li, Qiuyun Tian, Yayan Pang, Chunguang Ren, Zhifang Dong","doi":"10.1016/j.neuron.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.10.018","url":null,"abstract":"Social creatures must attend to threat signals from conspecifics and respond appropriately, both behaviorally and physiologically. In this work, we show in mice a threat-sensitive immune mechanism that orchestrates psychological processes and is amenable to social modulation. Repeated encounters with socially cued threats triggered meningeal neutrophil (MN) priming preferentially in males. MN activity was correlated with attenuated defensive responses to cues. Canonical neutrophil-specific activation marker CD177 was upregulated after social threat cueing, and its genetic ablation abrogated male behavioral phenotypes. CD177 signals favored meningeal T helper (Th)1-like immune bias, which blunted neural response to threatening stimuli by enhancing intrinsic GABAergic inhibition within the prelimbic cortex via interferon-gamma (IFN-γ). MN signaling was sensitized by negative emotional states and governed by socially dependent androgen release. This male-biased hormone/neutrophil regulatory axis is seemingly conserved in humans. Our findings provide insights into how immune responses influence behavioral threat responses, suggesting a possible neuroimmune basis of emotional regulation.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability of cross-sensory input to primary somatosensory cortex across experience. 初级躯体感觉皮层跨感觉输入在不同经历中的稳定性。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-13 DOI: 10.1016/j.neuron.2024.10.020

Daniel D Kato, Randy M Bruno

引用次数: 0

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Appoptosin 介导的 Caspase 对 Tau 的裂解有助于渐进性核上性麻痹的发病机制。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-08 DOI: 10.1016/j.neuron.2024.11.001

Yingjun Zhao, I-Chu Tseng, Charles J Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C Mobley, Yun-Wu Zhang, Peter St George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi Xu

引用次数: 0

Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function. Piezo1 在单一残基（丝氨酸-1612）上的磷酸化可调节其机械敏感性和体内机械传导功能。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-06 Epub Date: 2024-09-12 DOI: 10.1016/j.neuron.2024.08.009

Tingxin Zhang, Cheng Bi, Yiran Li, Lingyun Zhao, Yaxiong Cui, Kunfu Ouyang, Bailong Xiao

{"title":"Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function.","authors":"Tingxin Zhang, Cheng Bi, Yiran Li, Lingyun Zhao, Yaxiong Cui, Kunfu Ouyang, Bailong Xiao","doi":"10.1016/j.neuron.2024.08.009","DOIUrl":"10.1016/j.neuron.2024.08.009","url":null,"abstract":"Piezo1 is a mechanically activated cation channel that converts mechanical force into diverse physiological processes. Owing to its large protein size of more than 2,500 amino acids and complex 38-transmembrane helix topology, how Piezo1 is post-translationally modified for regulating its in vivo mechanotransduction functions remains largely unexplored. Here, we show that PKA activation potentiates the mechanosensitivity and slows the inactivation kinetics of mouse Piezo1 and identify the major phosphorylation site, serine-1612 (S1612), that also responds to PKC activation and shear stress. Mutating S1612 abolishes PKA and PKC regulation of Piezo1 activities. Primary endothelial cells derived from the Piezo1-S1612A knockin mice lost PKA- and PKC-dependent phosphorylation and functional potentiation of Piezo1. The mutant mice show activity-dependent elevation of blood pressure and compromised exercise endurance, resembling endothelial-specific Piezo1 knockout mice. Taken together, we identify the major PKA and PKC phosphorylation site in Piezo1 and demonstrate its contribution to Piezo1-mediated physiological functions.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3618-3633.e6"},"PeriodicalIF":14.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter aging and its impact on brain function. 白质老化及其对大脑功能的影响

IF 14.7 1区医学

Neuron Pub Date : 2024-11-06 DOI: 10.1016/j.neuron.2024.10.019

Janos Groh, Mikael Simons

引用次数: 0

Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme. 在癌症-神经界面调节钾离子通道可增强致痫性多形性胶质母细胞瘤的神经元兴奋性。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-06 DOI: 10.1016/j.neuron.2024.10.016

Ye Zhang, Wei Duan, Lingchao Chen, Junrui Chen, Wei Xu, Qi Fan, Shuwei Li, Yuandong Liu, Shidi Wang, Quansheng He, Xiaohui Li, Yang Huang, Haibao Peng, Jiaxu Zhao, Qiangqiang Zhang, Zhixin Qiu, Zhicheng Shao, Bo Zhang, Yihua Wang, Yang Tian, Yousheng Shu, Zhiyong Qin, Yudan Chi

{"title":"Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme.","authors":"Ye Zhang, Wei Duan, Lingchao Chen, Junrui Chen, Wei Xu, Qi Fan, Shuwei Li, Yuandong Liu, Shidi Wang, Quansheng He, Xiaohui Li, Yang Huang, Haibao Peng, Jiaxu Zhao, Qiangqiang Zhang, Zhixin Qiu, Zhicheng Shao, Bo Zhang, Yihua Wang, Yang Tian, Yousheng Shu, Zhiyong Qin, Yudan Chi","doi":"10.1016/j.neuron.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.10.016","url":null,"abstract":"The central nervous system (CNS) is increasingly recognized as a critical modulator in the oncogenesis of glioblastoma multiforme (GBM), with interactions between cancer and local neuronal circuits frequently leading to epilepsy; however, the relative contributions of these factors remain unclear. Here, we report a coordinated intratumor shift among distinct cancer subtypes within progenitor-like families of epileptic GBM patients, revealing an accumulation of oligodendrocyte progenitor (OPC)-like subpopulations at the cancer-neuron interface along with heightened electrical signaling activity in the surrounding neuronal networks. The OPC-like cells associated with epilepsy express KCND2, which encodes the voltage-gated K+ channel KV4.2, enhancing neuronal excitability via accumulation of extracellular K+, as demonstrated in patient-derived ex vivo slices, xenografting models, and engineering organoids. Together, we uncovered the essential local circuitry, cellular components, and molecular mechanisms facilitating cancer-neuron interaction at peritumor borders. KCND2 plays a crucial role in mediating nervous system-cancer electrical communication, suggesting potential targets for intervention.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From animal models to human individuality: Integrative approaches to the study of brain plasticity. 从动物模型到人类个性：研究大脑可塑性的综合方法。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-06 Epub Date: 2024-10-25 DOI: 10.1016/j.neuron.2024.10.006

Maike Hille, Simone Kühn, Gerd Kempermann, Tobias Bonhoeffer, Ulman Lindenberger

{"title":"From animal models to human individuality: Integrative approaches to the study of brain plasticity.","authors":"Maike Hille, Simone Kühn, Gerd Kempermann, Tobias Bonhoeffer, Ulman Lindenberger","doi":"10.1016/j.neuron.2024.10.006","DOIUrl":"10.1016/j.neuron.2024.10.006","url":null,"abstract":"Plasticity allows organisms to form lasting adaptive changes in neural structures in response to interactions with the environment. It serves both species-general functions and individualized skill acquisition. To better understand human plasticity, we need to strengthen the dialogue between human research and animal models. Therefore, we propose to (1) enhance the interpretability of macroscopic methods used in human research by complementing molecular and fine-structural measures used in animals with such macroscopic methods, preferably applied to the same animals, to create macroscopic metrics common to both examined species; (2) launch dedicated cross-species research programs, using either well-controlled experimental paradigms, such as motor skill acquisition, or more naturalistic environments, where individuals of either species are observed in their habitats; and (3) develop conceptual and computational models linking molecular and fine-structural events to phenomena accessible by macroscopic methods. In concert, these three component strategies can foster new insights into the nature of plastic change.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3522-3541"},"PeriodicalIF":14.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brainstem circuit amplifies aversion. 脑干回路放大了厌恶感。

IF 14.7 1区医学

Neuron Pub Date : 2024-11-06 Epub Date: 2024-09-12 DOI: 10.1016/j.neuron.2024.08.010

Jingwen Liang, Yu Zhou, Qiru Feng, Youtong Zhou, Tao Jiang, Miao Ren, Xueyan Jia, Hui Gong, Run Di, Peijie Jiao, Minmin Luo

引用次数: 0

Representing the dynamics of natural marmoset vocal behaviors in frontal cortex. 在额叶皮层表现自然狨猴发声行为的动态变化

IF 3.784 1区医学

Neuron Pub Date : 2024-11-06 Epub Date: 2024-09-23 DOI: 10.1016/j.neuron.2024.08.020

Jingwen Li, Mikio C Aoi, Cory T Miller