Neuron最新文献 - Book学术

A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma. regg - extl3轴参与的肿瘤周围微环境促进了胰腺导管腺癌中神经与肿瘤的相互作用。

IF 15 1区医学

Neuron Pub Date : 2026-05-07 DOI: 10.1016/j.neuron.2026.03.039

Shan Zhang, Fang-Yuan Dong, Shuqi Cai, Bin Zhou, Luju Jiang, Li-Peng Hu, Yu-Heng Zhu, Hui Li, Xiao-Mei Yang, Zhiwei Cai, Lin-Li Yao, Hao Wang, Hong-Fei Yao, Jun Li, Qing Li, Lei Zhu, Qin Yang, Li-Min Liu, Yan-Qiu Yu, Jun-Feng Zhang, Rong Hua, Xue-Li Zhang, Helen He Zhu, Ningning Niu, Jing Xue, Chongyi Jiang, Yong-Wei Sun, Qingjian Han, Dong-Xue Li, De-Jun Liu, Zhi-Gang Zhang, Shu-Heng Jiang

{"title":"A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma.","authors":"Shan Zhang, Fang-Yuan Dong, Shuqi Cai, Bin Zhou, Luju Jiang, Li-Peng Hu, Yu-Heng Zhu, Hui Li, Xiao-Mei Yang, Zhiwei Cai, Lin-Li Yao, Hao Wang, Hong-Fei Yao, Jun Li, Qing Li, Lei Zhu, Qin Yang, Li-Min Liu, Yan-Qiu Yu, Jun-Feng Zhang, Rong Hua, Xue-Li Zhang, Helen He Zhu, Ningning Niu, Jing Xue, Chongyi Jiang, Yong-Wei Sun, Qingjian Han, Dong-Xue Li, De-Jun Liu, Zhi-Gang Zhang, Shu-Heng Jiang","doi":"10.1016/j.neuron.2026.03.039","DOIUrl":"https://doi.org/10.1016/j.neuron.2026.03.039","url":null,"abstract":"Tumor innervation (TIN) and perineural invasion (PNI) are well-established pathological features of pancreatic ductal adenocarcinoma (PDAC) that drive its aggressiveness and associated pain. Here, we reveal that regenerating islet-derived (Reg) proteins, secreted by peritumoral exocrine acinar cells, facilitate TIN and PNI through two paracrine mechanisms. In PDAC cells, Reg proteins drive cancer invasiveness along nerves via autocrine transforming growth factor β (TGF-β) signaling. In neurons, Reg proteins are neurotrophic and potentiate neuronal excitability, resulting in hyperinnervation and pain. Interleukin-22, primarily produced by CD4+ T cells, triggers Reg expression. Exostosin-like glycosyltransferase 3 (EXTL3) is the functional receptor for Reg proteins in both cell types. Genetic silencing of Reg or EXTL3 reduces TIN, nerve-cancer proximity, PDAC progression, and pain behavior in mice. Clinically, the Reg-EXTL3-TGF-β axis correlates with increased TIN and PNI severity, poor prognosis, and greater pain. Thus, targeting the Reg-EXTL3 axis may be an attractive strategy for mitigating neural-associated adverse consequences in PDAC.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neurovascular survival axis for adult sympathetic neurons. 成体交感神经元的神经血管存活轴。

IF 15 1区医学

Neuron Pub Date : 2026-05-07 DOI: 10.1016/j.neuron.2026.04.004

Zhu Zhu, Wanling Lin, Liang Xiao, Zhihao Qian, Ting He, Wentao Wang, Yuanjiao Wang, Xiaoxuan Zhang, Bingrui Zhao, Huiqi Xie, Xinghua Quan, Yanxiao Zhang, Min Jiang, Xuzhao Li, Lili Zhou, Dongdong Zhang, Hualin Yu, Ziyu Liu, Lingyun Bao, Jie-Min Jia

{"title":"A neurovascular survival axis for adult sympathetic neurons.","authors":"Zhu Zhu, Wanling Lin, Liang Xiao, Zhihao Qian, Ting He, Wentao Wang, Yuanjiao Wang, Xiaoxuan Zhang, Bingrui Zhao, Huiqi Xie, Xinghua Quan, Yanxiao Zhang, Min Jiang, Xuzhao Li, Lili Zhou, Dongdong Zhang, Hualin Yu, Ziyu Liu, Lingyun Bao, Jie-Min Jia","doi":"10.1016/j.neuron.2026.04.004","DOIUrl":"https://doi.org/10.1016/j.neuron.2026.04.004","url":null,"abstract":"Adult neuronal survival underlies lifelong brain function, yet its sustaining mechanisms remain unclear. We identify a neurovascular survival axis at intracranial arteries in mice, where superior cervical ganglion (SCG) sympathetic terminals form synapse-like neurosmooth muscular junctions (NsMJs) with arterial smooth muscle cells (aSMCs) that secrete netrin-4 (Ntn4). Adult aSMC-restricted Ntn4 deletion selectively reduces rostral, intracranial-projecting (cerebrospinal fluid-traced) SCG neurons; the denervation of the intracranial arterial plexus follows soma loss. Local recombinant Ntn4 delivery to the SCG rescues these phenotypes. Ntn4 withdrawal engages a receptor-interacting serine/threonine kinase 1 (RIPK1)/mixed lineage kinase domain-like pseudokinase (MLKL)-linked, caspase-independent, non-inflammatory death program via deleted in colorectal cancer (DCC): unliganded DCC triggers neuronal loss, whereas Dcc knockout preserves vulnerable neurons. Arterial Ntn4 declines from young adulthood and precedes selective neuronal attrition before midlife; aSMC-targeted Ntn4 overexpression prevents this loss. Together, intracranial arteries provide a local, non-cell-autonomous trophic niche that maintains this adult sympathetic subset and becomes compromised as vascular Ntn4 output wanes with age.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catching a ride: Nanoparticles bypass the blood-brain barrier. 搭车：纳米粒子绕过血脑屏障。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.026

Senfeng Zhao, Miranda Li Xu, Wei Tao

引用次数: 0

A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons. 骨源性激素通过VTA gaba能神经元亚群中的GPR37受体允许快速视觉逃逸。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-04-18 DOI: 10.1016/j.neuron.2026.04.006

Xuemei Liu, Shuaiyu Wang, Juan Lai, Xiang Gao, Lina Wang, Bo Feng, Liang Yang, Zhengjiang Qian, Ruotian Jiang, Jun Chu, Liming Tan, Xiang Li, Liping Wang

引用次数: 0

Targeting pain: Cryo-EM guides the discovery of a novel TRPM3 antagonist. 靶向疼痛：冷冻电镜引导发现一种新的TRPM3拮抗剂。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.03.036

Carter D Burton, Tibor Rohacs

引用次数: 0

Linking neural manifolds to circuit structure in recurrent networks. 在循环网络中连结神经流形与回路结构。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-03-06 DOI: 10.1016/j.neuron.2025.12.047

Louis Pezon, Valentin Schmutz, Wulfram Gerstner

{"title":"Linking neural manifolds to circuit structure in recurrent networks.","authors":"Louis Pezon, Valentin Schmutz, Wulfram Gerstner","doi":"10.1016/j.neuron.2025.12.047","DOIUrl":"10.1016/j.neuron.2025.12.047","url":null,"abstract":"Dimensionality reduction methods are widely used in neuroscience to investigate two complementary aspects of neural activity: the distribution of single-neuron functional properties and the low-dimensional collective dynamics of population activity. However, how do these two aspects of neural activity relate to the structure of the underlying neural circuit? In this work, we connect circuit structure, single-neuron functional properties, and emerging low-dimensional dynamics in spiking recurrent network models. Our models explain how topologically distinct circuit structures can produce equivalent low-dimensional dynamics. Despite this degeneracy, we find that circuit structure imposes specific constraints on both the low-dimensional dynamics of population activity and the distribution of single-neuron functional properties. These constraints yield simple criteria for comparing network models with observed neural activity. Our modeling framework not only links classical models of cortical circuits to the more recent notion of neural manifolds but also paves the way for designing tractable models of population dynamics that are better aligned with neural recordings.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1682-1694.e21"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lineage-based model of scalable positional information in vertebrate brain development. 脊椎动物大脑发育中可扩展位置信息的基于谱系的模型。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-03-02 DOI: 10.1016/j.neuron.2025.12.043

Stan Kerstjens, Florian Engert, Rodney J Douglas, Anthony M Zador

引用次数: 0

Inventing the future: A neuroscience research roadmap. 创造未来：神经科学研究路线图。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.008

John Ngai

引用次数: 0

Ventral hippocampal NPY interneurons regulate circadian feeding in mice. 小鼠海马腹侧NPY中间神经元调节昼夜摄食。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-02-19 DOI: 10.1016/j.neuron.2025.12.034

Zhi-Han Jiao, Yan-Jiao Wu, Xin Bian, Chih-Ming Wang, Ze-Ka Chen, Ping Dong, Taylor Landry, Ying Li, Qin Jiang, Nehemiah Stewart, Li-Ming Hsu, Yen-Yu Ian Shih, Ya-Dong Li, Xing-Lei Song, Juan Song, Tian-Le Xu

{"title":"Ventral hippocampal NPY interneurons regulate circadian feeding in mice.","authors":"Zhi-Han Jiao, Yan-Jiao Wu, Xin Bian, Chih-Ming Wang, Ze-Ka Chen, Ping Dong, Taylor Landry, Ying Li, Qin Jiang, Nehemiah Stewart, Li-Ming Hsu, Yen-Yu Ian Shih, Ya-Dong Li, Xing-Lei Song, Juan Song, Tian-Le Xu","doi":"10.1016/j.neuron.2025.12.034","DOIUrl":"10.1016/j.neuron.2025.12.034","url":null,"abstract":"Feeding behavior is tightly regulated by circadian rhythms, and disruption of this coordination promotes mistimed eating and metabolic dysfunction. Here, using mouse models, we identify a noncanonical role of neuropeptide Y-expressing interneurons (NPY-INs) in the ventral hippocampus (vHPC) in circadian feeding control. vHPC NPY-INs exhibit robust diurnal activity fluctuations that are lost under chronic circadian disruption. Functionally, these neurons regulate feeding across the day-night cycle by engaging distinct transmitters: NPY signaling predominates during the light phase, whereas gamma-aminobutyric acid (GABA) signaling dominates during the dark phase. Furthermore, vHPC NPY-INs receive monosynaptic glutamatergic and GABAergic inputs from the medial preoptic area (MPOA), which confer circadian plasticity, and project to the ventral subiculum (vSub), where NPY1R and NPY2R signaling mediates feeding behavior. Together, these findings identify the vHPC NPY-INs as a critical hub linking circadian regulation and energy balance, offering new insight into neural mechanisms underlying mistimed feeding and metabolic disorders.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1666-1681.e7"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control. 局部交感免疫轴通过控制肾上腺素能抑制小鼠黑色素瘤的生长。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-04-29 DOI: 10.1016/j.neuron.2026.04.016

Tingting Liu, Daniel Y Kutsovsky, Ethan M Earlie, Liangliang Ji, Michael Iskols, Shakti Ramsamooj, Xavier I Dawkins, Marwa Zerhouni, Alexander Birbrair, Elena Piskounova, Ming O Li, Ashley M Laughney, David J Simon

{"title":"A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control.","authors":"Tingting Liu, Daniel Y Kutsovsky, Ethan M Earlie, Liangliang Ji, Michael Iskols, Shakti Ramsamooj, Xavier I Dawkins, Marwa Zerhouni, Alexander Birbrair, Elena Piskounova, Ming O Li, Ashley M Laughney, David J Simon","doi":"10.1016/j.neuron.2026.04.016","DOIUrl":"10.1016/j.neuron.2026.04.016","url":null,"abstract":"The nervous system drives tumor growth directly through intra-tumoral axons and indirectly through the systemic action of hormones. Yet contexts where the nervous system inhibits tumor growth are less defined. Here, we performed optical reconstruction of axonal innervation in mouse models of cutaneous melanoma, revealing progressive innervation by sympathetic axons. Local depletion of these axons accelerates while local optogenetic activation slows melanoma growth, together consistent with these axons acting as a physiological growth brake. The sympathetic nervous system is typically associated with driving tumor growth through activation of β-adrenergic receptors (ARs). Here, we find that the initial tumor seeding conditions sensitize melanomas from βAR-driven growth promotion toward α2-AR-driven growth inhibition. Mechanistically, the axonal activation of α2 ARs restricts the number and distribution of pro-tumor myeloid cells, independently of T cell activity. Together, our data reveal context-dependent, bidirectional neural control of tumor progression.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1576-1593.e8"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0