Neuron最新文献 - Book学术

Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states. 自发运动及其与神经活动的关系随潜在接触状态而波动。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-30 DOI: 10.1016/j.neuron.2025.06.001

Chaoqun Yin, Maxwell D Melin, Gabriel Rojas-Bowe, Xiaonan Richard Sun, João Couto, Steven Gluf, Alex Kostiuk, Simon Musall, Anne K Churchland

{"title":"Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.","authors":"Chaoqun Yin, Maxwell D Melin, Gabriel Rojas-Bowe, Xiaonan Richard Sun, João Couto, Steven Gluf, Alex Kostiuk, Simon Musall, Anne K Churchland","doi":"10.1016/j.neuron.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.06.001","url":null,"abstract":"Switching between cognitive states is a natural tendency, even for trained experts. To test how cognitive states impact neural activity and behavior, we measured cortex-wide neural activity during decision-making in mice. During disengagement, neural activity was more variable across trials and could be better explained by a linear encoding model. This increase in explained variance during disengagement was associated with two changes: modestly stronger neural encoding of movements generally and an increase in task-independent movements specifically. Surprisingly, behavioral videos showed similar motion energy in both cognitive states. But while the overall amount of movements remained similar, movement alignment changed: as animals slipped into disengagement, their movements became less stereotyped. These idiosyncratic movements were a strong predictor of task performance and engagement. Taken together, our results suggest that the temporal structure of movement patterns constitutes an embodied signature of the cognitive state with a profound relationship to neural activity.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex. 不同的树突整合策略控制新皮层抑制的动态。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-30 DOI: 10.1016/j.neuron.2025.05.029

Annunziato Morabito, Yann Zerlaut, Dhanasak Dhanasobhon, Emmanuelle Berthaux, Cibele Martins Pinho, Alexandra Tzilivaki, Gael Moneron, Laurence Cathala, Panayiota Poirazi, Alberto Bacci, David A DiGregorio, Joana Lourenço, Nelson Rebola

{"title":"Distinct dendritic integration strategies control dynamics of inhibition in the neocortex.","authors":"Annunziato Morabito, Yann Zerlaut, Dhanasak Dhanasobhon, Emmanuelle Berthaux, Cibele Martins Pinho, Alexandra Tzilivaki, Gael Moneron, Laurence Cathala, Panayiota Poirazi, Alberto Bacci, David A DiGregorio, Joana Lourenço, Nelson Rebola","doi":"10.1016/j.neuron.2025.05.029","DOIUrl":"10.1016/j.neuron.2025.05.029","url":null,"abstract":"Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We found that the two major cortical IN subtypes-somatostatin (SST)- and parvalbumin (PV)-expressing cells-use distinct strategies for distributing and integrating excitatory synaptic inputs along their dendrites. SST-INs exhibit NMDAR-dependent supralinear integration and a uniform distribution of synapses, whereas PV-INs show sublinear integration with a higher density of synapses on proximal dendrites with low NMDAR expression. Compartmental modeling revealed that, while both strategies enhance synaptic efficacy, passive integration and proximally biased inputs enable precise tracking of fast-changing signals in PV-INs, whereas NMDARs in SST-INs promote broader temporal integration, supporting sustained activity tuned to slower input variations. Consistent with these predictions, in vivo measurements showed differentially shaped dynamic visual responses in PV- and SST-INs. Therefore, the heterogeneity of dendritic mechanisms strongly influences the spatiotemporal dynamics of IN-specific inhibition in cortical circuits.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Satellite glial cells: Shaping peripheral input into the brain-body axis? 卫星胶质细胞：塑造外围输入到脑-体轴？

IF 14.7 1区医学

Neuron Pub Date : 2025-06-27 DOI: 10.1016/j.neuron.2025.05.031

Pauline Meriau, Rejji Kuruvilla, Valeria Cavalli

引用次数: 0

A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses. 哺乳动物外周和中枢突触突触前稳态可塑性的统一机制。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-26 DOI: 10.1016/j.neuron.2025.05.030

Peter H Chipman, Unghwi Lee, Brian O Orr, Richard D Fetter, Graeme W Davis

{"title":"A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses.","authors":"Peter H Chipman, Unghwi Lee, Brian O Orr, Richard D Fetter, Graeme W Davis","doi":"10.1016/j.neuron.2025.05.030","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.030","url":null,"abstract":"Presynaptic homeostatic plasticity (PHP) is a potent form of adaptive plasticity that has been documented at synapses as diverse as the glutamatergic Drosophila neuromuscular junction (NMJ), cholinergic mammalian NMJ (including human), and glutamatergic synapses in the mammalian brain. We define secreted class III semaphorin as a unifying, trans-synaptic signal necessary for PHP at highly divergent synapses. Sema3a drives the rapid induction of PHP at the cholinergic mouse NMJ and synapses in the adult hippocampus (CA1), including cross-modal potentiation of inhibitory transmission. Three-dimensional electron microscopy (EM) reveals Sema3a-dependent active zone expansion, presynaptic stabilization, and the maintenance of synapse organization during PHP. Mechanistically, Sema3a promotes vesicle redistribution from a non-releasing to recycling and readily releasable vesicle pool. Finally, presynaptic-signal transduction is also commonly deployed, requiring activation of PlexinA4 and an integrin beta-1 (ITGB1) co-receptor. The widespread utilization of common PHP mechanisms emphasizes the translational potential of model organisms toward promoting neuronal resilience to combat brain disorders and disease.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encoding the glucose identity by discrete hypothalamic neurons via the gut-brain axis 通过肠-脑轴编码离散下丘脑神经元的葡萄糖身份

IF 16.2 1区医学

Neuron Pub Date : 2025-06-20 DOI: 10.1016/j.neuron.2025.05.024

Jineun Kim, Shinhye Kim, Wongyo Jung, Yujin Kim, Seongju Lee, Sehun Kim, Hae-Yong Park, Dae Young Yoo, In Koo Hwang, Robert C. Froemke, Seung-Hee Lee, Young-Gyun Park, Gary J. Schwartz, Greg S.B. Suh

{"title":"Encoding the glucose identity by discrete hypothalamic neurons via the gut-brain axis","authors":"Jineun Kim, Shinhye Kim, Wongyo Jung, Yujin Kim, Seongju Lee, Sehun Kim, Hae-Yong Park, Dae Young Yoo, In Koo Hwang, Robert C. Froemke, Seung-Hee Lee, Young-Gyun Park, Gary J. Schwartz, Greg S.B. Suh","doi":"10.1016/j.neuron.2025.05.024","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.024","url":null,"abstract":"Animals need daily intakes of three macronutrients: sugar, protein, and fat. Under fasted conditions, however, animals prioritize sugar as a primary source of energy. They must detect ingested sugar—specifically D-glucose—and quickly report its presence to the brain. Hypothalamic neurons that can respond to the caloric content in the gut regardless of the identity of macronutrient have been identified, but until now, the existence of neurons that can encode the specific macronutrients remained unknown. We found that a subset of corticotropin-releasing factor (CRF)-expressing neurons in the hypothalamic paraventricular nucleus (CRF<ce:sup loc=\"post\">PVN</ce:sup>) respond specifically to D-glucose in the gut, separately from other macronutrients or sugars. CRF<ce:sup loc=\"post\">PVN</ce:sup> neuronal activity is essential for fasted mice to develop a preference for D-glucose. These responses of CRF<ce:sup loc=\"post\">PVN</ce:sup> neurons to intestinal D-glucose require a specific spinal gut-brain pathway including the dorsal lateral parabrachial nuclei. These findings reveal the neural circuit that encodes the identity of D-glucose.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"43 1","pages":""},"PeriodicalIF":16.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is criticality a unified setpoint of brain function? 临界状态是大脑功能的统一设定值吗？

IF 14.7 1区医学

Neuron Pub Date : 2025-06-19 DOI: 10.1016/j.neuron.2025.05.020

Keith B Hengen, Woodrow L Shew

引用次数: 0

The interpeduncular nucleus blunts the rewarding effect of nicotine. 针间核减弱了尼古丁的奖赏作用。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 Epub Date: 2025-04-21 DOI: 10.1016/j.neuron.2025.03.035

Joachim Jehl, Maria Ciscato, Eléonore Vicq, Nicolas Guyon, Gabrielle Dejean de la Batie, Sarah Mondoloni, Jacinthe Frangieh, Monir Mohayyaei, Claire Nguyen, Stéphanie Pons, Uwe Maskos, Jean-Pierre Hardelin, Fabio Marti, Pierre-Jean Corringer, Philippe Faure, Alexandre Mourot

{"title":"The interpeduncular nucleus blunts the rewarding effect of nicotine.","authors":"Joachim Jehl, Maria Ciscato, Eléonore Vicq, Nicolas Guyon, Gabrielle Dejean de la Batie, Sarah Mondoloni, Jacinthe Frangieh, Monir Mohayyaei, Claire Nguyen, Stéphanie Pons, Uwe Maskos, Jean-Pierre Hardelin, Fabio Marti, Pierre-Jean Corringer, Philippe Faure, Alexandre Mourot","doi":"10.1016/j.neuron.2025.03.035","DOIUrl":"10.1016/j.neuron.2025.03.035","url":null,"abstract":"Nicotine stimulates ventral tegmental area (VTA) dopaminergic neurons, producing a rewarding effect that drives tobacco consumption. The interpeduncular nucleus (IPN) is thought to become engaged at high nicotine doses to limit drug intake, but its response dynamics are unknown. We developed a chemogenetic approach using a \"suicide\" antagonist that selectively attaches to designer β4 nicotinic acetylcholine receptors (nAChRs) in genetically modified mice, enabling sustained and pharmacologically specific antagonism. Local infusion in the IPN revealed that nicotine, even at low doses, simultaneously activates and inhibits two distinct populations of IPN neurons, with β4-containing nAChRs mediating only the activation response. Blocking nicotine-induced IPN activation enhanced VTA responses and increased the drug's rewarding effect in a conditioned place preference paradigm. Moreover, optogenetic inhibition of IPN projections to the laterodorsal tegmental nucleus (LDTg) replicated these behavioral effects. Our findings indicate that the IPN acts as a regulatory brake on the nicotine reward circuit via the LDTg.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1898-1907.e6"},"PeriodicalIF":14.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distal tuft dendrites predict properties of new hippocampal place fields. 远端丛状树突预测新海马位场的性质。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 Epub Date: 2025-04-17 DOI: 10.1016/j.neuron.2025.03.029

Justin K O'Hare, Jamie Wang, Margjele D Shala, Franck Polleux, Attila Losonczy

{"title":"Distal tuft dendrites predict properties of new hippocampal place fields.","authors":"Justin K O'Hare, Jamie Wang, Margjele D Shala, Franck Polleux, Attila Losonczy","doi":"10.1016/j.neuron.2025.03.029","DOIUrl":"10.1016/j.neuron.2025.03.029","url":null,"abstract":"Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new \"place fields.\" Distal tuft dendrites have been proposed to drive place field formation via dendritic plateau potentials. However, the relationship between distal dendritic and somatic activity is unknown in vivo. Here, we gained simultaneous optical access to distal tuft dendrites and their soma in head-fixed mice navigating virtual reality environments. While distal tuft dendrites rarely express local peri-formation plateau potentials, the timing and extent of their recruitment predict properties of resultant somatic place fields. Following somatic place field formation, distal tuft dendrites readily express plateau potentials as well as local place fields that are back shifted relative to that of their soma. Distal tuft dendrites may therefore undergo local plasticity during somatic place field formation. Through direct in vivo observation, we provide an updated dendritic basis for hippocampal feature selectivity during navigational learning.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1969-1982.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orchestrating prefrontal cognitive control: The thalamus in command. 协调前额叶认知控制：丘脑的指挥。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 DOI: 10.1016/j.neuron.2025.05.021

Randolph F Helfrich

引用次数: 0

A parallel tonotopically arranged thalamocortical circuit for sound processing. 一种平行排列的用于声音处理的丘脑皮层回路。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-18 Epub Date: 2025-04-15 DOI: 10.1016/j.neuron.2025.03.022

Zhikai Zhao, Xiaojing Tang, Yiheng Chen, Jie Tao, Mahiber Polat, Zhiqi Yang, Linhan Yang, Meng Wang, Shanshan Liang, Kuan Zhang, Yun Zhang, Chunqing Zhang, Lina Wang, Yanjiang Wang, Arthur Konnerth, Hongbo Jia, Wei Xiong, Xiang Liao, Sunny C Li, Xiaowei Chen

{"title":"A parallel tonotopically arranged thalamocortical circuit for sound processing.","authors":"Zhikai Zhao, Xiaojing Tang, Yiheng Chen, Jie Tao, Mahiber Polat, Zhiqi Yang, Linhan Yang, Meng Wang, Shanshan Liang, Kuan Zhang, Yun Zhang, Chunqing Zhang, Lina Wang, Yanjiang Wang, Arthur Konnerth, Hongbo Jia, Wei Xiong, Xiang Liao, Sunny C Li, Xiaowei Chen","doi":"10.1016/j.neuron.2025.03.022","DOIUrl":"10.1016/j.neuron.2025.03.022","url":null,"abstract":"The perception of the sensory world in mammals requires information flow from the thalamus to the cortex. Although the first-order sensory thalamus and its surrounding nuclei are considered the major hub for feedforward thalamocortical transmission, it remains unknown whether any other thalamic input could also contribute to this transmission. We found a thalamic region, the basal region of the ventromedial nucleus of the thalamus (bVM), that sends dense, tonotopically arranged projections to auditory cortex (AuC) fields. Silencing these AuC-projecting neurons severely impaired the mouse's ability to discriminate sound frequencies. These projections exhibited strong frequency-tuning preferences that matched the cortical tonotopic map. Moreover, bVM inputs were excitatory and primarily terminated on neuron-derived neurotrophic factor-positive interneurons in cortical layer 1. Silencing these inputs significantly reduced sound-evoked responses of AuC neurons. Our results reveal a non-canonical, tonotopically arranged thalamic input to cortical layer 1 that contributes to sound processing, in parallel to the classic auditory thalamocortical pathway.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1998-2013.e6"},"PeriodicalIF":14.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0