Neuron最新文献 - Book学术

A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps. 两种算法的故事：结构化槽解释了前额叶序列记忆，并与海马认知图谱相统一。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-21 DOI: 10.1016/j.neuron.2024.10.017

James C R Whittington, William Dorrell, Timothy E J Behrens, Surya Ganguli, Mohamady El-Gaby

{"title":"A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps.","authors":"James C R Whittington, William Dorrell, Timothy E J Behrens, Surya Ganguli, Mohamady El-Gaby","doi":"10.1016/j.neuron.2024.10.017","DOIUrl":"10.1016/j.neuron.2024.10.017","url":null,"abstract":"Remembering events is crucial to intelligent behavior. Flexible memory retrieval requires a cognitive map and is supported by two key brain systems: hippocampal episodic memory (EM) and prefrontal working memory (WM). Although an understanding of EM is emerging, little is understood of WM beyond simple memory retrieval. We develop a mathematical theory relating the algorithms and representations of EM and WM by unveiling a duality between storing memories in synapses versus neural activity. This results in a formalism of prefrontal WM as structured, controllable neural subspaces (activity slots) representing dynamic cognitive maps without synaptic plasticity. Using neural networks, we elucidate differences, similarities, and trade-offs between the hippocampal and prefrontal algorithms. Lastly, we show that prefrontal representations in tasks from list learning to cue-dependent recall are unified as controllable activity slots. Our results unify frontal and temporal representations of memory and offer a new understanding for dynamic prefrontal representations of WM.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"321-333.e6"},"PeriodicalIF":14.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hypothalamic node for the cyclical control of female sexual rejection. 周期性控制女性性排斥的下丘脑节点。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-25 DOI: 10.1016/j.neuron.2024.10.026

Nicolas Gutierrez-Castellanos, Basma Fatima Anwar Husain, Inês C Dias, Kensaku Nomoto, Margarida A Duarte, Liliana Ferreira, Bertrand Lacoste, Susana Q Lima

{"title":"A hypothalamic node for the cyclical control of female sexual rejection.","authors":"Nicolas Gutierrez-Castellanos, Basma Fatima Anwar Husain, Inês C Dias, Kensaku Nomoto, Margarida A Duarte, Liliana Ferreira, Bertrand Lacoste, Susana Q Lima","doi":"10.1016/j.neuron.2024.10.026","DOIUrl":"10.1016/j.neuron.2024.10.026","url":null,"abstract":"Internal state-dependent behavioral flexibility, such as the ability to switch between rejecting and accepting sexual advances based on a female's reproductive capacity, is crucial for maintaining meaningful social interactions. While the role of the ventrolateral ventromedial hypothalamus (VMHvl) in sexual acceptance is well established, the neural mechanisms underlying sexual rejection remain unexplored. In this study, we identify progesterone receptor-expressing neurons in the anterior VMHvl (aVMHvlPR+) as key regulators of cyclical female sexual rejection behavior. In vivo recordings reveal that these neurons are active during sexual rejection but inactive during sexual acceptance. Slice electrophysiology demonstrates that aVMHvlPR+ neurons receive a reduced excitatory-to-inhibitory synaptic input balance in receptive females. Furthermore, activating and inhibiting aVMHvlPR+ neurons increases rejection in receptive females and reduces rejection in non-receptive females, respectively. Thus, aVMHvlPR+ neurons constitute a critical neural substrate controlling female sexual behavior, providing an additional barrier to mating when fertilization is not possible.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"277-290.e8"},"PeriodicalIF":14.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The unbearable slowness of being: Why do we live at 10 bits/s? 生命难以忍受的缓慢：为什么我们以每秒10比特的速度生活？

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-12-17 DOI: 10.1016/j.neuron.2024.11.008

Jieyu Zheng, Markus Meister

引用次数: 0

Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping. 识别 CA1 中的表征结构，为认知映射理论模型提供基准。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-22 DOI: 10.1016/j.neuron.2024.10.027

J Quinn Lee, Alexandra T Keinath, Erica Cianfarano, Mark P Brandon

引用次数: 0

NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics. NMDA 受体在不改变单细胞动力学的情况下调节海马回路的点燃率设定点。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-07 DOI: 10.1016/j.neuron.2024.10.014

Antonella Ruggiero, Leore R Heim, Lee Susman, Dema Hreaky, Ilana Shapira, Maxim Katsenelson, Kobi Rosenblum, Inna Slutsky

{"title":"NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics.","authors":"Antonella Ruggiero, Leore R Heim, Lee Susman, Dema Hreaky, Ilana Shapira, Maxim Katsenelson, Kobi Rosenblum, Inna Slutsky","doi":"10.1016/j.neuron.2024.10.014","DOIUrl":"10.1016/j.neuron.2024.10.014","url":null,"abstract":"Understanding how neuronal circuits stabilize their activity is a fundamental yet poorly understood aspect of neuroscience. Here, we show that hippocampal network properties, such as firing rate distribution and dimensionality, are actively regulated, despite perturbations and single-cell drift. Continuous inhibition of N-methyl-D-aspartate receptors (NMDARs) ex vivo lowers the excitation/inhibition ratio and network firing rates while preserving resilience to perturbations. This establishes a new network firing rate set point via NMDAR-eEF2K signaling pathway. NMDARs' capacity to modulate and stabilize network firing is mediated by excitatory synapses and the intrinsic excitability of parvalbumin-positive neurons, respectively. In behaving mice, continuous NMDAR blockade in CA1 reduces network firing without altering single-neuron drift or triggering a compensatory response. These findings expand NMDAR function beyond their canonical role in synaptic plasticity and raise the possibility that some NMDAR-dependent behavioral effects are mediated by their unique regulation of population activity set points.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"244-259.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme. 在癌症-神经界面调节钾离子通道可增强致痫性多形性胶质母细胞瘤的神经元兴奋性。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-11 DOI: 10.1016/j.neuron.2024.10.016

Ye Zhang, Wei Duan, Lingchao Chen, Junrui Chen, Wei Xu, Qi Fan, Shuwei Li, Yuandong Liu, Shidi Wang, Quansheng He, Xiaohui Li, Yang Huang, Haibao Peng, Jiaxu Zhao, Qiangqiang Zhang, Zhixin Qiu, Zhicheng Shao, Bo Zhang, Yihua Wang, Yang Tian, Yousheng Shu, Zhiyong Qin, Yudan Chi

{"title":"Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme.","authors":"Ye Zhang, Wei Duan, Lingchao Chen, Junrui Chen, Wei Xu, Qi Fan, Shuwei Li, Yuandong Liu, Shidi Wang, Quansheng He, Xiaohui Li, Yang Huang, Haibao Peng, Jiaxu Zhao, Qiangqiang Zhang, Zhixin Qiu, Zhicheng Shao, Bo Zhang, Yihua Wang, Yang Tian, Yousheng Shu, Zhiyong Qin, Yudan Chi","doi":"10.1016/j.neuron.2024.10.016","DOIUrl":"10.1016/j.neuron.2024.10.016","url":null,"abstract":"The central nervous system (CNS) is increasingly recognized as a critical modulator in the oncogenesis of glioblastoma multiforme (GBM), with interactions between cancer and local neuronal circuits frequently leading to epilepsy; however, the relative contributions of these factors remain unclear. Here, we report a coordinated intratumor shift among distinct cancer subtypes within progenitor-like families of epileptic GBM patients, revealing an accumulation of oligodendrocyte progenitor (OPC)-like subpopulations at the cancer-neuron interface along with heightened electrical signaling activity in the surrounding neuronal networks. The OPC-like cells associated with epilepsy express KCND2, which encodes the voltage-gated K+ channel KV4.2, enhancing neuronal excitability via accumulation of extracellular K+, as demonstrated in patient-derived ex vivo slices, xenografting models, and engineering organoids. Together, we uncovered the essential local circuitry, cellular components, and molecular mechanisms facilitating cancer-neuron interaction at peritumor borders. KCND2 plays a crucial role in mediating nervous system-cancer electrical communication, suggesting potential targets for intervention.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"225-243.e10"},"PeriodicalIF":14.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal working memory activity slots support sequence memory similar to hippocampal long-term memory position recall.

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 DOI: 10.1016/j.neuron.2024.12.022

Yannik Hilla, Charline Peylo, Paul Sauseng

引用次数: 0

Stability of cross-sensory input to primary somatosensory cortex across experience. 初级躯体感觉皮层跨感觉输入在不同经历中的稳定性。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-18 DOI: 10.1016/j.neuron.2024.10.020

Daniel D Kato, Randy M Bruno

引用次数: 0

Meningeal neutrophil immune signaling influences behavioral adaptation following threat. 脑膜中性粒细胞免疫信号影响受威胁后的行为适应。

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 Epub Date: 2024-11-18 DOI: 10.1016/j.neuron.2024.10.018

Bin Wu, Ling Meng, Yan Zhao, Junjie Li, Qiuyun Tian, Yayan Pang, Chunguang Ren, Zhifang Dong

{"title":"Meningeal neutrophil immune signaling influences behavioral adaptation following threat.","authors":"Bin Wu, Ling Meng, Yan Zhao, Junjie Li, Qiuyun Tian, Yayan Pang, Chunguang Ren, Zhifang Dong","doi":"10.1016/j.neuron.2024.10.018","DOIUrl":"10.1016/j.neuron.2024.10.018","url":null,"abstract":"Social creatures must attend to threat signals from conspecifics and respond appropriately, both behaviorally and physiologically. In this work, we show in mice a threat-sensitive immune mechanism that orchestrates psychological processes and is amenable to social modulation. Repeated encounters with socially cued threats triggered meningeal neutrophil (MN) priming preferentially in males. MN activity was correlated with attenuated defensive responses to cues. Canonical neutrophil-specific activation marker CD177 was upregulated after social threat cueing, and its genetic ablation abrogated male behavioral phenotypes. CD177 signals favored meningeal T helper (Th)1-like immune bias, which blunted neural response to threatening stimuli by enhancing intrinsic GABAergic inhibition within the prelimbic cortex via interferon-gamma (IFN-γ). MN signaling was sensitized by negative emotional states and governed by socially dependent androgen release. This male-biased hormone/neutrophil regulatory axis is seemingly conserved in humans. Our findings provide insights into how immune responses influence behavioral threat responses, suggesting a possible neuroimmune basis of emotional regulation.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"260-276.e8"},"PeriodicalIF":14.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Like, share, and spike: Glioblastoma progenitors influence neuronal excitability at the glioma-neural interface.

IF 14.7 1区医学

Neuron Pub Date : 2025-01-22 DOI: 10.1016/j.neuron.2024.12.021

Christopher W Mount, Mario L Suvà

引用次数: 0