Neuron最新文献 - Book学术

Neuroethics hackathons bridge theory to practice.

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 DOI: 10.1016/j.neuron.2024.11.013

Karen S Rommelfanger, Darrell Porcello, Arleen Salles, Lucille Nalbach Tournas

引用次数: 0

Functional architecture of cerebral cortex during naturalistic movie watching. 自然观影过程中大脑皮层的功能结构。

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-11-06 DOI: 10.1016/j.neuron.2024.10.005

Reza Rajimehr, Haoran Xu, Asa Farahani, Simon Kornblith, John Duncan, Robert Desimone

引用次数: 0

Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons. 以丘脑室旁神经元为目标的皮质-丘脑回路的功能特性

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-11-05 DOI: 10.1016/j.neuron.2024.10.010

Guillermo Aquino-Miranda, Dounya Jalloul, Xu O Zhang, Sa Li, Gilbert J Kirouac, Michael Beierlein, Fabricio H Do Monte

{"title":"Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons.","authors":"Guillermo Aquino-Miranda, Dounya Jalloul, Xu O Zhang, Sa Li, Gilbert J Kirouac, Michael Beierlein, Fabricio H Do Monte","doi":"10.1016/j.neuron.2024.10.010","DOIUrl":"10.1016/j.neuron.2024.10.010","url":null,"abstract":"Corticothalamic projections to sensorimotor thalamic nuclei show modest firing rates and serve to modulate the activity of thalamic relay neurons. By contrast, here we find that high-order corticothalamic projections from the prelimbic (PL) cortex to the anterior paraventricular thalamic nucleus (aPVT) maintain high-frequency activity and evoke strong synaptic excitation of aPVT neurons in rats. In a significant fraction of aPVT cells, such high-frequency excitation of PL-aPVT projections leads to a rapid decay of action potential amplitudes, followed by a depolarization block (DB) that strongly limits aPVT maximum firing rates, thereby regulating both defensive and appetitive behaviors in a frequency-dependent manner. Strong inhibitory inputs from the anteroventral portion of the thalamic reticular nucleus (avTRN) inhibit the firing rate of aPVT neurons during periods of high-spike fidelity but restore it during prominent DB, suggesting that avTRN activity can modulate the effects of PL inputs on aPVT firing rates to ultimately control motivated behaviors.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"4060-4080.e7"},"PeriodicalIF":14.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complexity demands more flexibility and the prefrontal cortex has an answer.

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 DOI: 10.1016/j.neuron.2024.11.017

Talha Soluoku, James M Hyman

引用次数: 0

Split-second insights from the brain's dual-stream visual system.

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 DOI: 10.1016/j.neuron.2024.11.014

Se-Bum Paik

引用次数: 0

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway. 人类集合体揭示了丘脑皮层通路中 CACNA1G 基因变异的后果。

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-10-16 DOI: 10.1016/j.neuron.2024.09.020

Ji-Il Kim, Yuki Miura, Min-Yin Li, Omer Revah, Sridhar Selvaraj, Fikri Birey, Xiangling Meng, Mayuri Vijay Thete, Sergey D Pavlov, Jimena Andersen, Anca M Pașca, Matthew H Porteus, John R Huguenard, Sergiu P Pașca

{"title":"Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway.","authors":"Ji-Il Kim, Yuki Miura, Min-Yin Li, Omer Revah, Sridhar Selvaraj, Fikri Birey, Xiangling Meng, Mayuri Vijay Thete, Sergey D Pavlov, Jimena Andersen, Anca M Pașca, Matthew H Porteus, John R Huguenard, Sergiu P Pașca","doi":"10.1016/j.neuron.2024.09.020","DOIUrl":"10.1016/j.neuron.2024.09.020","url":null,"abstract":"Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium channel, are associated with absence seizures, intellectual disability, and schizophrenia, but the cellular and circuit consequences of these genetic variants in humans remain unknown. Here, we developed a human assembloid model of the thalamocortical pathway to dissect the contribution of genetic variants in T-type calcium channels. We discovered that the M1531V CACNA1G variant associated with seizures led to changes in T-type currents in thalamic neurons, as well as correlated hyperactivity of thalamic and cortical neurons in assembloids. By contrast, CACNA1G loss, which has been associated with risk of schizophrenia, resulted in abnormal thalamocortical connectivity that was related to both increased spontaneous thalamic activity and aberrant axonal projections. These results illustrate the utility of multi-cellular systems for interrogating human genetic disease risk variants at both cellular and circuit level.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"4048-4059.e7"},"PeriodicalIF":14.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental complexity modulates information processing and the balance between decision-making systems. 环境的复杂性会调节信息处理和决策系统之间的平衡。

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-10-29 DOI: 10.1016/j.neuron.2024.10.004

Ugurcan Mugan, Samantha L Hoffman, A David Redish

{"title":"Environmental complexity modulates information processing and the balance between decision-making systems.","authors":"Ugurcan Mugan, Samantha L Hoffman, A David Redish","doi":"10.1016/j.neuron.2024.10.004","DOIUrl":"10.1016/j.neuron.2024.10.004","url":null,"abstract":"Behavior in naturalistic scenarios occurs in diverse environments. Adaptive strategies rely on multiple neural circuits and competing decision systems. However, past studies of rodent decision making have largely measured behavior in simple environments. To fill this gap, we recorded neural ensembles from hippocampus (HC), dorsolateral striatum (DLS), and dorsomedial prefrontal cortex (dmPFC) while rats foraged for food under changing rules in environments with varying topological complexity. Environmental complexity increased behavioral variability, lengthened HC nonlocal sequences, and modulated action caching. We found contrasting representations between DLS and HC, supporting a competition between decision systems. dmPFC activity was indicative of setting this balance, in particular predicting the extent of HC non-local coding. Inactivating mPFC impaired short-term behavioral adaptation and produced long-term deficits in balancing decision systems. Our findings reveal the dynamic nature of decision-making systems and how environmental complexity modulates their engagement with implications for behavior in naturalistic environments.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"4096-4114.e10"},"PeriodicalIF":14.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Give me a sign(ature): Converging on the CSC of glioblastoma.

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 DOI: 10.1016/j.neuron.2024.11.012

Kunal S Patel, Lindsey Dudley, Harley I Kornblum

引用次数: 0

Accurate neural control of a hand prosthesis by posture-related activity in the primate grasping circuit. 通过灵长类动物抓握回路中与姿势相关的活动对假手进行精确的神经控制。

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-10-16 DOI: 10.1016/j.neuron.2024.09.018

Andres Agudelo-Toro, Jonathan A Michaels, Wei-An Sheng, Hansjörg Scherberger

引用次数: 0

Spatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex. 空间情境非均匀地调节初级视觉皮层的层间信息流

IF 14.7 1区医学

Neuron Pub Date : 2024-12-18 Epub Date: 2024-10-22 DOI: 10.1016/j.neuron.2024.09.021

Xize Xu, Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson, Anirvan S Nandy, Monika P Jadi

{"title":"Spatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex.","authors":"Xize Xu, Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson, Anirvan S Nandy, Monika P Jadi","doi":"10.1016/j.neuron.2024.09.021","DOIUrl":"10.1016/j.neuron.2024.09.021","url":null,"abstract":"Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet, how the spatial organization of objects influences this activity remains poorly understood. We investigate how inter-laminar information flow within the primary visual cortex (V1) is affected by visual stimuli in isolation or with flankers at spatial configurations that are known to cause non-uniform degradation of perception. By employing dimensionality reduction approaches to simultaneous, layer-specific population recordings, we establish that information propagation between cortical layers occurs along a structurally stable communication subspace. The spatial configuration of contextual stimuli differentially modulates inter-laminar communication efficacy, the balance of feedforward and effective feedback signaling, and contextual signaling in the superficial layers. Remarkably, these modulations mirror the spatially non-uniform aspects of perceptual degradation. Our results suggest a model of retinotopically non-uniform cortical connectivity in the output layers of V1 that influences information flow in the sensory hierarchy.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"4081-4095.e5"},"PeriodicalIF":14.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0