Neuron最新文献 - Book学术

Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal. 阿片类药物驱动的隔膜破坏揭示了神经紧张素表达神经元在戒断中的作用。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-14 DOI: 10.1016/j.neuron.2025.04.024

Rhiana C Simon, Weston T Fleming, Brandy A Briones, Marta Trzeciak, Pranav Senthilkumar, Kentaro K Ishii, Madelyn M Hjort, Madison M Martin, Koichi Hashikawa, Andrea D Sanders, Sam A Golden, Garret D Stuber

{"title":"Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.","authors":"Rhiana C Simon, Weston T Fleming, Brandy A Briones, Marta Trzeciak, Pranav Senthilkumar, Kentaro K Ishii, Madelyn M Hjort, Madison M Martin, Koichi Hashikawa, Andrea D Sanders, Sam A Golden, Garret D Stuber","doi":"10.1016/j.neuron.2025.04.024","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.04.024","url":null,"abstract":"Opioid withdrawal is an intensively aversive experience and often drives relapse. The lateral septum (LS) is a forebrain structure that is important in aversion processing and has been linked to substance use disorders, but which LS cell types contribute to the maladaptive state of withdrawal is unknown. We used single-nucleus RNA sequencing to interrogate cell-type-specific gene expression changes induced by chronic morphine exposure and discovered that morphine globally disrupts LS cell types, but neurotensin-expressing neurons (LS-Nts) are selectively activated by naloxone. Using two-photon calcium imaging and ex vivo electrophysiology, we next demonstrate that LS-Nts neurons receive elevated glutamatergic drive in morphine-dependent mice and remain hyperactivated during withdrawal. Finally, we show that manipulating LS-Nts neurons during opioid withdrawal regulates pain coping and sociability. Together, these results suggest that LS-Nts neurons are a key neural substrate involved in opioid withdrawal and establish the LS as a crucial regulator of adaptive behaviors.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network influence determines the impact of cortical ensembles on stimulus detection. 网络影响决定了皮层集合对刺激检测的影响。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-13 DOI: 10.1016/j.neuron.2025.04.023

Hayley A Bounds, Hillel Adesnik

引用次数: 0

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming. NeuroD1诱导小胶质细胞凋亡，不能诱导小胶质细胞到神经元的跨系重编程。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-13 DOI: 10.1016/j.neuron.2025.05.006

Yanxia Rao, Siling Du, Baozhi Yang, Yuqing Wang, Yuxin Li, Ruofan Li, Tian Zhou, Xiangjuan Du, Yang He, Yafei Wang, Xin Zhou, Ti-Fei Yuan, Ying Mao, Bo Peng

引用次数: 0

Presynaptic α₂δs specify synaptic gain, not synaptogenesis, in the mammalian brain. 在哺乳动物大脑中，突触前α2δs指定突触增益，而不是突触发生。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-09 DOI: 10.1016/j.neuron.2025.04.013

William Milanick, Jianing Li, Connon I Thomas, Mohammed Al-Yaari, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M Young

{"title":"Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain.","authors":"William Milanick, Jianing Li, Connon I Thomas, Mohammed Al-Yaari, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M Young","doi":"10.1016/j.neuron.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.04.013","url":null,"abstract":"The α2δs are a family of extracellular synaptic molecules that are auxiliary subunits of voltage-gated Ca2+ channel (CaV) complexes. They are linked to brain disorders and are drug targets. The α2δs are implicated in controlling synapse development and function through distinct CaV-dependent and CaV-independent pathways. However, the mechanisms of action remain enigmatic since synapses contain mixtures of α2δ isoforms in the pre- and postsynaptic compartments. We developed a triple conditional knockout mouse model and demonstrated the combined selective presynaptic ablation of α2δs in vivo in a developing mammalian glutamatergic synapse. We identified presynaptic α2δs as positive regulators of Munc13-1 levels, an essential neurotransmitter release protein. We found that mammalian synapse development, presynaptic CaV2.1 organization, and the transsynaptic alignment of presynaptic release sites and postsynaptic glutamate receptors are independent of presynaptic α2δs. Therefore, our results define presynaptic α2δ regulatory roles and suggest a new α2δ role in controlling synaptic strength and plasticity.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural circuit underlying individual differences in visual escape habituation. 视觉逃避习惯个体差异背后的神经回路。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-08 DOI: 10.1016/j.neuron.2025.04.018

Xuemei Liu, Juan Lai, Chuanliang Han, Hao Zhong, Kang Huang, Yuanming Liu, Xutao Zhu, Pengfei Wei, Liming Tan, Fuqiang Xu, Liping Wang

引用次数: 0

An unexpected mediator of pain-driven opioid use in males-estrogen. 男性疼痛驱动阿片类药物使用的意想不到的中介-雌激素。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.008

Rebecca M Shansky

引用次数: 0

NAD⁺ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. NAD+通过CX43-PARP1轴修复衰老诱导的血脑屏障损伤。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-04-17 DOI: 10.1016/j.neuron.2025.04.002

Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y Eugene Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng

引用次数: 0

The nervous system and cancer: A grand challenge and a call to collaborate. 神经系统和癌症：一个巨大的挑战和合作的呼吁。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.009

Gabriela Carreno, Gemma M Balmer, Rebecca L Eccles

引用次数: 0

Experience influences the refinement of feature selectivity in the mouse primary visual thalamus. 经验影响小鼠初级视觉丘脑特征选择性的完善

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-19 DOI: 10.1016/j.neuron.2025.02.023

Takuma Sonoda, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R Uzgare, Michela Fagiolini, Michael E Greenberg, Chinfei Chen

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Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males. 雌二醇通过抑制雄性阿片类诱发的多巴胺活性来防止芬太尼的使用。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-10 DOI: 10.1016/j.neuron.2025.02.013

Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón

{"title":"Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males.","authors":"Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón","doi":"10.1016/j.neuron.2025.02.013","DOIUrl":"10.1016/j.neuron.2025.02.013","url":null,"abstract":"Pain relief is the most frequently reported motivation for opioid misuse, but it remains unclear how pain alters reward pathway function contributing to maladaptive opioid use and whether these neuroadaptations occur in a sex-specific manner. Here, we show that persistent inflammatory pain leads to augmented fentanyl self-administration in male, not female, rats. Wireless in vivo fiber photometry recordings and chemogenetic manipulations indicate that pain-facilitated fentanyl use is mediated by enhanced ventral tegmental area dopamine (VTADA) neuron responses during self-administration. In females, ovariectomy enhances fentanyl self-administration, but the protective effects of ovarian hormones are not solely mediated by estradiol per se. Instead, pain and high estradiol states-naturally occurring in intact females or artificially produced in males-suppress fentanyl self-administration and associated VTADA activity through VTA estrogen receptor beta signaling. These findings highlight the importance of assessing hormonal factors in opioid misuse liability in the context of pain.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1413-1429.e5"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0