IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.03.025

Colleen A McClung

引用次数: 0

Shaping sight: Novel thalamic plasticity channels dLGN feature preference during visual critical period. 视觉塑造：视觉关键期新丘脑可塑性通道与lgn特征偏好。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.001

Chuying Zhou, Xiang Gao, Liming Tan

引用次数: 0

TMEM63B functions as a mammalian hyperosmolar sensor for thirst. TMEM63B作为哺乳动物口渴的高渗传感器。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-18 DOI: 10.1016/j.neuron.2025.02.012

Wenjie Zou, Siqi Deng, Xingyu Chen, Jiamin Ruan, Huize Wang, Wuqiang Zhan, Jingxin Wang, Zhiyong Liu, Zhiqiang Yan

引用次数: 0

PI3P: Rising to the (DPR) challenge in C9-ALS/FTD. PI3P：应对C9-ALS/FTD的（DPR）挑战。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.007

Janani Parameswaran, Zachary T McEachin

引用次数: 0

The predictive nature of spontaneous brain activity across scales and species. 跨尺度和跨物种的自发脑活动的预测性。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-17 DOI: 10.1016/j.neuron.2025.02.009

Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta

{"title":"The predictive nature of spontaneous brain activity across scales and species.","authors":"Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta","doi":"10.1016/j.neuron.2025.02.009","DOIUrl":"10.1016/j.neuron.2025.02.009","url":null,"abstract":"Emerging research suggests the brain operates as a \"prediction machine,\" continuously anticipating sensory, motor, and cognitive outcomes. Central to this capability is the brain's spontaneous activity-ongoing internal processes independent of external stimuli. Neuroimaging and computational studies support that this activity is integral to maintaining and refining mental models of our environment, body, and behaviors, akin to generative models in computation. During rest, spontaneous activity expands the variability of potential representations, enhancing the accuracy and adaptability of these models. When performing tasks, internal models direct brain regions to anticipate sensory and motor states, optimizing performance. This review synthesizes evidence from various species, from C. elegans to humans, highlighting three key aspects of spontaneous brain activity's role in prediction: the similarity between spontaneous and task-related activity, the encoding of behavioral and interoceptive priors, and the high metabolic cost of this activity, underscoring prediction as a fundamental function of brains across species.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1310-1332"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human pain neuroscience and the next generation of pain therapeutics. 人类疼痛神经科学和下一代疼痛疗法。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.005

Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao

引用次数: 0

A gut-wrenching tale of neuronal distress. 一个关于神经元痛苦的令人揪心的故事。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.03.033

Murillo Duarte-Silva, Meenakshi Rao

引用次数: 0

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease. APOE 基因型决定了阿尔茨海默病的细胞特异性病理特征。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-19 DOI: 10.1016/j.neuron.2025.02.017

Zonghua Li, Yuka A Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V Doss, Naomi Kouri, Monica Castanedes-Casey, Trace A Christensen, Lindsay B Miller Nevalainen, Nanaka Takegami, Kai Chen, Chia-Chen Liu, Alexandra Soto-Beasley, Baayla D C Boon, Sydney A Labuzan, Tadafumi C Ikezu, Yixing Chen, Alexander D Bartkowiak, Gisela Xhafkollari, Allison M Wetmore, David A Bennett, Ross R Reichard, Ronald C Petersen, Takahisa Kanekiyo, Owen A Ross, Melissa E Murray, Dennis W Dickson, Guojun Bu, Na Zhao

{"title":"APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.","authors":"Zonghua Li, Yuka A Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V Doss, Naomi Kouri, Monica Castanedes-Casey, Trace A Christensen, Lindsay B Miller Nevalainen, Nanaka Takegami, Kai Chen, Chia-Chen Liu, Alexandra Soto-Beasley, Baayla D C Boon, Sydney A Labuzan, Tadafumi C Ikezu, Yixing Chen, Alexander D Bartkowiak, Gisela Xhafkollari, Allison M Wetmore, David A Bennett, Ross R Reichard, Ronald C Petersen, Takahisa Kanekiyo, Owen A Ross, Melissa E Murray, Dennis W Dickson, Guojun Bu, Na Zhao","doi":"10.1016/j.neuron.2025.02.017","DOIUrl":"10.1016/j.neuron.2025.02.017","url":null,"abstract":"The apolipoprotein E (APOE) gene is the strongest genetic risk modifier for Alzheimer's disease (AD), with the APOE4 allele increasing risk and APOE2 decreasing it compared with the common APOE3 allele. Using single-nucleus RNA sequencing of the temporal cortex from APOE2 carriers, APOE3 homozygotes, and APOE4 carriers, we found that AD-associated transcriptomic changes were highly APOE genotype dependent. Comparing AD with controls, APOE2 carriers showed upregulated synaptic and myelination-related pathways, preserving synapses and myelination at the protein level. Conversely, these pathways were downregulated in APOE3 homozygotes, resulting in reduced synaptic and myelination proteins. In APOE4 carriers, excitatory neurons displayed reduced synaptic pathways similar to APOE3, but oligodendrocytes showed upregulated myelination pathways like APOE2. However, their synaptic and myelination protein levels remained unchanged or increased. APOE4 carriers also showed increased pro-inflammatory signatures in microglia but reduced responses to amyloid-β pathology. These findings reveal APOE genotype-specific molecular alterations in AD across cell types.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1380-1397.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep stages antagonistically modulate reactivation drift. 睡眠阶段对抗性地调节再激活漂移。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-24 DOI: 10.1016/j.neuron.2025.02.025

Lars Bollmann, Peter Baracskay, Federico Stella, Jozsef Csicsvari

引用次数: 0

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum. 多队列脑脊液蛋白质组学在阿尔茨海默病连续体中识别出强大的分子特征。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-14 DOI: 10.1016/j.neuron.2025.02.014

Muhammad Ali, Jigyasha Timsina, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Anh Do, Gyujin Heo, Lihua Wang, Jen Gentsch, Suzanne E Schindler, John C Morris, David M Holtzman, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward N Wilson, Yann Le Guen, Rana R Khalid, Chloe Robins, David J Pulford, Rawan Tarawneh, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung, Carlos Cruchaga

{"title":"Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.","authors":"Muhammad Ali, Jigyasha Timsina, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Anh Do, Gyujin Heo, Lihua Wang, Jen Gentsch, Suzanne E Schindler, John C Morris, David M Holtzman, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward N Wilson, Yann Le Guen, Rana R Khalid, Chloe Robins, David J Pulford, Rawan Tarawneh, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung, Carlos Cruchaga","doi":"10.1016/j.neuron.2025.02.014","DOIUrl":"10.1016/j.neuron.2025.02.014","url":null,"abstract":"Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel. The identified proteins cluster in four different pseudo-trajectories groups spanning the AD continuum and were enriched in pathways including neuronal death, apoptosis, and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfunction (mid stages), brain plasticity and longevity (mid stages), and microglia-neuron crosstalk (late stages). Using machine learning, we created and validated highly accurate and replicable (area under the curve [AUC] > 0.90) models that predict AD biomarker positivity and clinical status. These models can also identify people that will convert to AD.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1363-1379.e9"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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