Neuron最新文献_第2页

Inventing the future: A neuroscience research roadmap. 创造未来：神经科学研究路线图。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.008

John Ngai

引用次数: 0

A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control. 局部交感免疫轴通过控制肾上腺素能抑制小鼠黑色素瘤的生长。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-04-29 DOI: 10.1016/j.neuron.2026.04.016

Tingting Liu, Daniel Y Kutsovsky, Ethan M Earlie, Liangliang Ji, Michael Iskols, Shakti Ramsamooj, Xavier I Dawkins, Marwa Zerhouni, Alexander Birbrair, Elena Piskounova, Ming O Li, Ashley M Laughney, David J Simon

{"title":"A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control.","authors":"Tingting Liu, Daniel Y Kutsovsky, Ethan M Earlie, Liangliang Ji, Michael Iskols, Shakti Ramsamooj, Xavier I Dawkins, Marwa Zerhouni, Alexander Birbrair, Elena Piskounova, Ming O Li, Ashley M Laughney, David J Simon","doi":"10.1016/j.neuron.2026.04.016","DOIUrl":"10.1016/j.neuron.2026.04.016","url":null,"abstract":"The nervous system drives tumor growth directly through intra-tumoral axons and indirectly through the systemic action of hormones. Yet contexts where the nervous system inhibits tumor growth are less defined. Here, we performed optical reconstruction of axonal innervation in mouse models of cutaneous melanoma, revealing progressive innervation by sympathetic axons. Local depletion of these axons accelerates while local optogenetic activation slows melanoma growth, together consistent with these axons acting as a physiological growth brake. The sympathetic nervous system is typically associated with driving tumor growth through activation of β-adrenergic receptors (ARs). Here, we find that the initial tumor seeding conditions sensitize melanomas from βAR-driven growth promotion toward α2-AR-driven growth inhibition. Mechanistically, the axonal activation of α2 ARs restricts the number and distribution of pro-tumor myeloid cells, independently of T cell activity. Together, our data reveal context-dependent, bidirectional neural control of tumor progression.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1576-1593.e8"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The response to danger: Is it in your bones? 对危险的反应：它在你的骨子里吗？

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.021

Isabella Canal Delgado, Gerard Karsenty

引用次数: 0

A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina. 视网膜中整合平行视觉处理的层次突触电路机制。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-02-19 DOI: 10.1016/j.neuron.2025.12.042

Yao Xue, Yue Fei, Marcello DiStasio, Sean J Miller, Brian P Hafler, Liang Liang, Seunghoon Lee, Z Jimmy Zhou

{"title":"A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina.","authors":"Yao Xue, Yue Fei, Marcello DiStasio, Sean J Miller, Brian P Hafler, Liang Liang, Seunghoon Lee, Z Jimmy Zhou","doi":"10.1016/j.neuron.2025.12.042","DOIUrl":"10.1016/j.neuron.2025.12.042","url":null,"abstract":"Parallel visual processing begins with retinal bipolar cells, traditionally regarded as independent chemical synaptic channels. However, the circuit-level synaptic integration of chemical and electrical synapses within this network remains unclear. Using dual patch-clamp recordings and two-photon imaging in whole-mount retina, we systematically characterized synaptic transmission across 13 mouse and 2 human cone bipolar cell (CBC) types, revealing two distinct modes: a fast, direct chemical pathway and a slower, serial electrical-chemical circuit among both ON and OFF CBCs. In mice, the slow mode generates spatially dispersed glutamate \"clouds\" that facilitate integration across CBC types. We discovered specific \"driver\" CBCs that distribute robust, sustained signals through a hierarchical, functionally rectified network, enhancing sensitivity to small, low-contrast stimuli in downstream retinal cells and thalamic neurons in awake mice. Our findings challenge the classical view of independent CBC channels, revealing an integrative, hierarchical electrical-chemical synaptic architecture that enhances visual detection and coding efficiency.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1651-1665.e6"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus. 全光电生理学揭示了海马中行为依赖的兴奋和抑制动力学。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-02-20 DOI: 10.1016/j.neuron.2025.12.040

Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London, Yoav Adam

引用次数: 0

The neuroscience of advanced meditation: The promise of third wave meditation research. 高级冥想的神经科学：第三波冥想研究的前景。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-03-25 DOI: 10.1016/j.neuron.2026.02.009

Matthew D Sacchet, Jonathan M Lieberman

引用次数: 0

The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective. 临床前阿尔茨海默病神经精神症状的出现：情绪调节的视角

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-03-10 DOI: 10.1016/j.neuron.2026.01.022

Adam Turnbull, James J Gross, Feng Vankee-Lin

{"title":"The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.","authors":"Adam Turnbull, James J Gross, Feng Vankee-Lin","doi":"10.1016/j.neuron.2026.01.022","DOIUrl":"10.1016/j.neuron.2026.01.022","url":null,"abstract":"Preclinical Alzheimer's disease (AD) is associated with distressing neuropsychiatric symptoms (NPSs) that may accelerate progression toward dementia. Existing approaches probe the symptom-level domain-general or domain-specific neural correlates of NPSs. However, the field lacks process-oriented models of symptom emergence for targeted treatment. We propose one pathway for symptom emergence involving the disruption of emotion regulation (ER) systems by early AD pathology. AD pathology in the ventral anterior cingulate cortex-ventromedial prefrontal cortex disrupts model-free ER that modulates negative valuations using experience-dependent reinforcement learning (e.g., fear extinction), leading to increased negative valuations and negative affect. We further propose that model-based ER competes for overtaxed executive resources and is less successful in preclinical AD, particularly in demanding real-world contexts. These changes lead to a shift toward negative affect, leading to divergent trajectories of NPSs depending on critical moderators. We discuss implications for intervention to improve NPSs and potentially slow dementia progression.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1551-1563"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finding clues to circuit structure in population dynamics and single-neuron selectivity. 在种群动态和单神经元选择性中寻找电路结构的线索。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.013

Tatiana A Engel

引用次数: 0

Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer's disease pathologies in mice. 小鼠肝脏APOE3基督城表达减轻apoe4相关的阿尔茨海默病病理。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 DOI: 10.1016/j.neuron.2026.04.027

Jin-Yi Tang, Qi Tan, Zhong-Yuan Yu, Zi-Yu Yuan, Ru Zeng, Xiao-Yu Liu, Xin-Yue Zhu, Yang Zhao, Jiang-Hui Li, Yu-Di Bai, Gui-Hua Zeng, Chao Wang, Yan-Jiang Wang

{"title":"Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer's disease pathologies in mice.","authors":"Jin-Yi Tang, Qi Tan, Zhong-Yuan Yu, Zi-Yu Yuan, Ru Zeng, Xiao-Yu Liu, Xin-Yue Zhu, Yang Zhao, Jiang-Hui Li, Yu-Di Bai, Gui-Hua Zeng, Chao Wang, Yan-Jiang Wang","doi":"10.1016/j.neuron.2026.04.027","DOIUrl":"https://doi.org/10.1016/j.neuron.2026.04.027","url":null,"abstract":"The ε4 allele of apolipoprotein E (APOE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD) and exacerbates AD-related pathologies. Identifying strategies to mitigate the pathogenic effects of APOE4 remains a critical challenge in the field of AD research. The rare APOE3 Christchurch (APOE3Ch) variant has been suggested to be potentially protective against AD. Our study investigated whether hepatic expression of APOE3Ch could mitigate APOE4-associated AD pathologies. We successfully delivered APOE3Ch or APOE3 into the liver by adeno-associated virus in APP/PS1 mice expressing human APOE4. We observed that hepatic APOE3Ch delivery reduced amyloid-β (Aβ) burden in the brain. Hepatic APOE3Ch expression attenuated neuroinflammation, neurodegeneration, and cognitive impairments. Mechanistically, APOE3Ch expression increased the capacity of Aβ clearance by monocytes and hepatocytes. Our findings demonstrate that hepatic APOE3Ch expression attenuates AD-type pathologies in APOE4-expressing APP/PS1 mice, highlighting liver-directed APOE3Ch gene transfer as a promising therapeutic strategy for APOE4-associated AD.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance. 运动诱导的下丘脑腹内侧类固醇生成因子-1神经元的激活介导耐力的改善。

IF 15 1区医学

Neuron Pub Date : 2026-05-06 Epub Date: 2026-02-12 DOI: 10.1016/j.neuron.2025.12.033

Morgan Kindel, Ryan J Post, Kyle Grose, Louise Lantier, Eunsang Hwang, Jamie R E Carty, Lenka Dohnalová, Lauren Lepeak, Hallie C Kern, Rachael Villari, Nitsan Goldstein, Emily Lo, Albert Yeung, Lukas Richie, Bridget Skelly, Jenna Golub, Manmeet Rai, Teppei Fujikawa, Julio E Ayala, Joel K Elmquist, Christoph A Thaiss, David H Wasserman, Kevin W Williams, Erik B Bloss, J Nicholas Betley

{"title":"Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance.","authors":"Morgan Kindel, Ryan J Post, Kyle Grose, Louise Lantier, Eunsang Hwang, Jamie R E Carty, Lenka Dohnalová, Lauren Lepeak, Hallie C Kern, Rachael Villari, Nitsan Goldstein, Emily Lo, Albert Yeung, Lukas Richie, Bridget Skelly, Jenna Golub, Manmeet Rai, Teppei Fujikawa, Julio E Ayala, Joel K Elmquist, Christoph A Thaiss, David H Wasserman, Kevin W Williams, Erik B Bloss, J Nicholas Betley","doi":"10.1016/j.neuron.2025.12.033","DOIUrl":"10.1016/j.neuron.2025.12.033","url":null,"abstract":"Repeated exercise produces robust physiological benefits and is the leading lifestyle intervention for human health. The benefits from exercise training result from the remodeling of skeletomuscular, cardiovascular, metabolic, and endocrine systems. In mice, we find that activation of the central nervous system following exercise is essential for subsequent endurance performance and metabolism benefits. Ventromedial hypothalamic steroidogenic factor-1 (SF1) neurons are activated following exercise, and repeated training results in increased post-exercise SF1 neuron activation. Exercise training increases the intrinsic excitability and density of excitatory synapses on SF1 neurons, suggesting that exercise history is encoded through hypothalamic plasticity. Inhibition of SF1 neuron output blocks endurance gains and metabolic improvements that result from exercise training. Conversely, stimulation of SF1 neurons following exercise enhances gains in endurance. These results demonstrate that exercise-induced hypothalamic SF1 neuron activity is essential for the coordination of physiological improvements following exercise training.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1564-1575.e9"},"PeriodicalIF":15.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0