利用MultiVINE-seq揭示神经血管疾病的风险。

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-10-01 DOI:10.1016/j.neuron.2025.09.016

Lynn van Olst, David Gate

引用次数: 0

摘要

在本期《神经元》杂志上，Reid等人介绍了MultiVINE-seq，这是一种单核多组学平台，用于分析人类脑血管和血管周围细胞的配对转录组和表观基因组图谱通过整合全基因组关联数据，他们将神经退行性疾病和脑血管疾病的风险变异映射到特定的血管和免疫细胞类型，揭示了不同的和趋同的致病途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unraveling neurovascular disease risk with MultiVINE-seq.

In this issue of Neuron, Reid et al. introduce MultiVINE-seq, a single-nucleus multi-omic platform for profiling human cerebrovascular and perivascular cells for paired transcriptomic and epigenomic profiling.¹ By integrating genome-wide association data, they map neurodegenerative and cerebrovascular disease risk variants to specific vascular and immune cell types, uncovering distinct and convergent pathogenic pathways.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.